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311 results on '"Roychoudhuri, Rahul"'

51. Inhibiting glycolytic metabolism enhances [CD8.sup.+] T cell memory and antitumor function

Author

Sukumar, Madhusudhanan, Liu, Jie, Ji, Yun, Subramanian, Murugan, Crompton, Joseph G., Yu, Zhiya, Roychoudhuri, Rahul, Palmer, Douglas C., Muranski, Pawel, Karoly, Edward D., Mohney, Robert P., Klebanoff, Christopher A., Lal, Ashish, Finkel, Toren, Restifo, Nicholas P., and Gattinoni, Luca

Subjects
CD8 lymphocytes -- Properties, Cellular therapy -- Research, Glucose metabolism -- Research, Cellular control mechanisms -- Observations, Health care industry
Abstract

Naive [CD8.sup.+] T cells rely upon oxidation of fatty acids as a primary source of energy. After antigen encounter, T cells shift to a glycolytic metabolism to sustain effector function. [...]

Published
2013
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52. CCR8 marks highly suppressive Treg cells within tumours but is dispensable for their accumulation and suppressive function

Author

Whiteside, Sarah K., primary, Grant, Francis M., additional, Gyori, David S., additional, Conti, Alberto G., additional, Imianowski, Charlotte J., additional, Kuo, Paula, additional, Nasrallah, Rabab, additional, Sadiyah, Firas, additional, Lira, Sergio A., additional, Tacke, Frank, additional, Eil, Robert L., additional, Burton, Oliver T., additional, Dooley, James, additional, Liston, Adrian, additional, Okkenhaug, Klaus, additional, Yang, Jie, additional, and Roychoudhuri, Rahul, additional

Published
2021
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53. BACH2 represses effector programs to stabilize Treg-mediated immune homeostasis

Author

Roychoudhuri, Rahul, Hirahara, Kiyoshi, Mousavi, Kambiz, Clever, David, Klebanoff, Christopher A., Bonelli, Michael, Sciumè, Giuseppe, Zare, Hossein, Vahedi, Golnaz, Dema, Barbara, Yu, Zhiya, Liu, Hui, Takahashi, Hayato, Rao, Mahadev, Muranski, Pawel, Crompton, Joseph G., Punkosdy, George, Bedognetti, Davide, Wang, Ena, Hoffmann, Victoria, Rivera, Juan, Marincola, Francesco M., Nakamura, Atsushi, Sartorelli, Vittorio, Kanno, Yuka, Gattinoni, Luca, Muto, Akihiko, Igarashi, Kazuhiko, OʼShea, John J., and Restifo, Nicholas P.

Published
2013
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54. Th17 Cells Are Long Lived and Retain a Stem Cell-like Molecular Signature

Author

Muranski, Pawel, Borman, Zachary A., Kerkar, Sid P., Klebanoff, Christopher A., Ji, Yun, Sanchez-Perez, Luis, Sukumar, Madhusudhanan, Reger, Robert N., Yu, Zhiya, Kern, Steven J., Roychoudhuri, Rahul, Ferreyra, Gabriela A., Shen, Wei, Durum, Scott K., Feigenbaum, Lionel, Palmer, Douglas C., Antony, Paul A., Chan, Chi-Chao, Laurence, Arian, Danner, Robert L., Gattinoni, Luca, and Restifo, Nicholas P.

Published
2011
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55. BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression

Author

Grant, Francis M., primary, Yang, Jie, primary, Nasrallah, Rabab, primary, Clarke, James, primary, Sadiyah, Firas, primary, Whiteside, Sarah K., primary, Imianowski, Charlotte J., primary, Kuo, Paula, primary, Vardaka, Panagiota, primary, Todorov, Tihomir, primary, Zandhuis, Nordin, primary, Patrascan, Ilinca, primary, Tough, David F., primary, Kometani, Kohei, primary, Eil, Robert, primary, Kurosaki, Tomohiro, primary, Okkenhaug, Klaus, primary, and Roychoudhuri, Rahul, primary

Published
2020
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56. Phosphoinositide 3-kinase δ inhibition promotes antitumor responses but antagonizes checkpoint inhibitors

Author

Lim, Ee Lyn, Cugliandolo, Fiorella M, Rosner, Dalya R, Gyori, David, Roychoudhuri, Rahul, Okkenhaug, Klaus, Roychoudhuri, Rahul [0000-0002-5392-1853], Okkenhaug, Klaus [0000-0002-9432-4051], and Apollo - University of Cambridge Repository

Subjects
Male, Class I Phosphatidylinositol 3-Kinases, Adaptive immunity, Immunology, chemical and pharmacologic phenomena, Cancer immunotherapy, Signal transduction, Cancer Vaccines, T-Lymphocytes, Regulatory, Lymphocyte Depletion, Mice, Phosphatidylinositol 3-Kinases, Antineoplastic Agents, Immunological, Costimulatory and Inhibitory T-Cell Receptors, Antigens, Neoplasm, Cell Line, Tumor, Neoplasms, Antineoplastic Combined Chemotherapy Protocols, Animals, Humans, Diphtheria Toxin, Drug Interactions, Phosphoinositide-3 Kinase Inhibitors, Quinazolinones, FOS: Clinical medicine, Disease Models, Animal, Treatment Outcome, Oncology, Purines, Female, T-Lymphocytes, Cytotoxic
Abstract

Multiple modes of immunosuppression restrain immune function within tumors. We previously reported that phosphoinositide 3-kinase δ (PI3Kδ) inactivation in mice confers resistance to a range of tumor models by disrupting immunosuppression mediated by regulatory T cells (Tregs). The PI3Kδ inhibitor idelalisib has proven highly effective in the clinical treatment of chronic lymphocytic leukemia and the potential to extend the use of PI3Kδ inhibitors to nonhematological cancers is being evaluated. In this work, we demonstrate that the antitumor effect of PI3Kδ inactivation is primarily mediated through the disruption of Treg function, and correlates with tumor dependence on Treg immunosuppression. Compared with Treg-specific PI3Kδ deletion, systemic PI3Kδ inactivation is less effective at conferring resistance to tumors. We show that PI3Kδ deficiency impairs the maturation and reduces the capacity of CD8+ cytotoxic T lymphocytes (CTLs) to kill tumor cells in vitro, and to respond to tumor antigen-specific immunization in vivo. PI3Kδ inactivation antagonized the antitumor effects of tumor vaccines and checkpoint blockade therapies intended to boost the CD8+ T cell response. These findings provide insights into mechanisms by which PI3Kδ inhibition promotes antitumor immunity and demonstrate that the mechanism is distinct from that mediated by immune checkpoint blockade.

Published
2018
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62. T cell stemness and dysfunction in tumors are triggered by a common mechanism

Author

Vodnala, Suman Kumar, primary, Eil, Robert, additional, Kishton, Rigel J., additional, Sukumar, Madhusudhanan, additional, Yamamoto, Tori N., additional, Ha, Ngoc-Han, additional, Lee, Ping-Hsien, additional, Shin, MinHwa, additional, Patel, Shashank J., additional, Yu, Zhiya, additional, Palmer, Douglas C., additional, Kruhlak, Michael J., additional, Liu, Xiaojing, additional, Locasale, Jason W., additional, Huang, Jing, additional, Roychoudhuri, Rahul, additional, Finkel, Toren, additional, Klebanoff, Christopher A., additional, and Restifo, Nicholas P., additional

Published
2019
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63. Permissivity of the NCI-60 cancer cell lines to oncolytic Vaccinia Virus GLV-1h68

Author

Bedognetti Davide, Di Pasquale Giovanni, Roychoudhuri Rahul, Pos Zoltan, Chen Nanhai G, Adams Sharon, Reinboth Jennifer, Yu Zhiya, Worschech Andrea, Ascierto Maria, Uccellini Lorenzo, Rossano Fabio, Ascierto Paolo A, Stroncek David F, Restifo Nicholas P, Wang Ena, Szalay Aladar A, and Marincola Francesco M

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Oncolytic viral therapy represents an alternative therapeutic strategy for the treatment of cancer. We previously described GLV-1h68, a modified Vaccinia Virus with exclusive tropism for tumor cells, and we observed a cell line-specific relationship between the ability of GLV-1h68 to replicate in vitro and its ability to colonize and eliminate tumor in vivo. Methods In the current study we surveyed the in vitro permissivity to GLV-1h68 replication of the NCI-60 panel of cell lines. Selected cell lines were also tested for permissivity to another Vaccinia Virus and a vesicular stomatitis virus (VSV) strain. In order to identify correlates of permissity to viral infection, we measured transcriptional profiles of the cell lines prior infection. Results We observed highly heterogeneous permissivity to VACV infection amongst the cell lines. The heterogeneity of permissivity was independent of tissue with the exception of B cell derivation. Cell lines were also tested for permissivity to another Vaccinia Virus and a vesicular stomatitis virus (VSV) strain and a significant correlation was found suggesting a common permissive phenotype. While no clear transcriptional pattern could be identified as predictor of permissivity to infection, some associations were observed suggesting multifactorial basis permissivity to viral infection. Conclusions Our findings have implications for the design of oncolytic therapies for cancer and offer insights into the nature of permissivity of tumor cells to viral infection.

Published
2011
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64. Increased cardiovascular mortality more than fifteen years after radiotherapy for breast cancer: a population-based study

Author

Darby Sarah, Cuzick Jack, Putcha Venkata, Robinson David, Roychoudhuri Rahul, and Møller Henrik

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Breast radiotherapy as practised in the 1970s and 1980s resulted in significant myocardial exposure, and this was higher when the left breast was treated. It has been proposed that this difference might result in greater cardiovascular mortality following irradiation of the left breast when compared with the right. Methods All cases of female breast cancer diagnosed between 1971 and 1988 and recorded on the Thames Cancer Registry database were followed up to the end of 2003 to identify cases who had died from ischaemic heart disease (IHD) or any cardiovascular disease (CVD). A proportional hazards regression analysis was performed, stratified by time since diagnosis, using as the baseline group those women with right-sided disease who did not receive radiotherapy, and adjusting for age at diagnosis. Results A total of 20,871 women with breast cancer were included in the analysis, of which 51% had left-sided disease. Mortality at 15+ years after diagnosis was increased in recipients of left-breast radiotherapy compared to non-irradiated women with right-sided breast cancer, both for IHD (hazard ratio 1.59; 95% confidence interval 1.21–2.08; p = 0.001) and all CVD (hazard ratio 1.27; 95% confidence interval 1.07–1.51; p = 0.006). When irradiated women with left-sided breast cancer were compared with irradiated women with right-sided breast cancer, cardiovascular mortality at 15+ years after diagnosis was raised by around 25% (IHD: hazard ratio 1.23; 95% confidence interval 0.95–1.60; p = 0.114; CVD: hazard ratio 1.25; 95% confidence interval 1.05–1.49; p = 0.014). Conclusion We have found an elevation in cardiovascular mortality more than 15 years after breast radiotherapy in women diagnosed with breast cancer between 1971 and 1988. The risk was greater following irradiation of the left breast compared with the right. This confirms that radiotherapy as practised in the 1970s and 1980s has resulted in significant long-term cardiac toxicity. In absolute terms, the increase in cardiovascular mortality induced by radiotherapy may be substantial, as these mortality events are relatively common.

Published
2007
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68. Bach2 Promotes B Cell Receptor–Induced Proliferation of B Lymphocytes and Represses Cyclin-Dependent Kinase Inhibitors

Author

Miura, Yuichi, primary, Morooka, Mizuho, additional, Sax, Nicolas, additional, Roychoudhuri, Rahul, additional, Itoh-Nakadai, Ari, additional, Brydun, Andrey, additional, Funayama, Ryo, additional, Nakayama, Keiko, additional, Satomi, Susumu, additional, Matsumoto, Mitsuyo, additional, Igarashi, Kazuhiko, additional, and Muto, Akihiko, additional

Published
2018
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70. T cell oxygen-sensing proteins establish an immunologically tolerant metastatic niche

Author

Clever, David, Roychoudhuri, Rahul, Constantinides, Michael G, Askenase, Michael H, Sukumar, Madhusudhanan, Klebanoff, Christopher A, Eil, Robert L, Hickman, Heather D, Yu, Zhiya, Pan, Jenny H, Palmer, Douglas C, Phan, Anthony T, Goulding, John, Gattinoni, Luca, Goldrath, Ananda W, Belkaid, Yasmine, and Restifo, Nicholas P

Subjects
Mice, Knockout, Lung Neoplasms, CD8-Positive T-Lymphocytes, Th1 Cells, Lymphocyte Activation, Adoptive Transfer, T-Lymphocytes, Regulatory, Article, Neuropilin-1, Prolyl Hydroxylases, Oxygen, Interferon-gamma, Mice, Animals, Neoplasm Metastasis, Glycolysis, Lung
Abstract

Cancer cells must evade immune responses at distant sites to establish metastases. The lung is a frequent site for metastasis. We hypothesized that lung-specific immunoregulatory mechanisms create an immunologically permissive environment for tumor colonization. We found that T-cell-intrinsic expression of the oxygen-sensing prolyl-hydroxylase (PHD) proteins is required to maintain local tolerance against innocuous antigens in the lung but powerfully licenses colonization by circulating tumor cells. PHD proteins limit pulmonary type helper (Th)-1 responses, promote CD4(+)-regulatory T (Treg) cell induction, and restrain CD8(+) T cell effector function. Tumor colonization is accompanied by PHD-protein-dependent induction of pulmonary Treg cells and suppression of IFN-γ-dependent tumor clearance. T-cell-intrinsic deletion or pharmacological inhibition of PHD proteins limits tumor colonization of the lung and improves the efficacy of adoptive cell transfer immunotherapy. Collectively, PHD proteins function in T cells to coordinate distinct immunoregulatory programs within the lung that are permissive to cancer metastasis. PAPERCLIP.

Published
2016

71. BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency

Author

Afzali, Behdad, primary, Grönholm, Juha, additional, Vandrovcova, Jana, additional, O'Brien, Charlotte, additional, Sun, Hong-Wei, additional, Vanderleyden, Ine, additional, Davis, Fred P, additional, Khoder, Ahmad, additional, Zhang, Yu, additional, Hegazy, Ahmed N, additional, Villarino, Alejandro V, additional, Palmer, Ira W, additional, Kaufman, Joshua, additional, Watts, Norman R, additional, Kazemian, Majid, additional, Kamenyeva, Olena, additional, Keith, Julia, additional, Sayed, Anwar, additional, Kasperaviciute, Dalia, additional, Mueller, Michael, additional, Hughes, Jason D, additional, Fuss, Ivan J, additional, Sadiyah, Mohammed F, additional, Montgomery-Recht, Kim, additional, McElwee, Joshua, additional, Restifo, Nicholas P, additional, Strober, Warren, additional, Linterman, Michelle A, additional, Wingfield, Paul T, additional, Uhlig, Holm H, additional, Roychoudhuri, Rahul, additional, Aitman, Timothy J, additional, Kelleher, Peter, additional, Lenardo, Michael J, additional, O'Shea, John J, additional, Cooper, Nichola, additional, and Laurence, Arian D J, additional

Published
2017
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72. Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche

Author

Clever, David, primary, Roychoudhuri, Rahul, additional, Constantinides, Michael G., additional, Askenase, Michael H., additional, Sukumar, Madhusudhanan, additional, Klebanoff, Christopher A., additional, Eil, Robert L., additional, Hickman, Heather D., additional, Yu, Zhiya, additional, Pan, Jenny H., additional, Palmer, Douglas C., additional, Phan, Anthony T., additional, Goulding, John, additional, Gattinoni, Luca, additional, Goldrath, Ananda W., additional, Belkaid, Yasmine, additional, and Restifo, Nicholas P., additional

Published
2016
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74. Abstract 4034: Immunotherapy generates selective pressure to create an escape tumor with increased susceptibility to treatment with T cell based therapies

Author

Pan, Jenny H., primary, Vodnala, Suman, additional, Eil, Robert L., additional, Yu, Zhiya, additional, Gartner, Jared, additional, Clever, David, additional, Roychoudhuri, Rahul, additional, Patel, Shashank J., additional, Klebanoff, Christopher A., additional, Sukumar, Madhu, additional, Yamamoto, Tori, additional, and Restifo, Nicholas P., additional

Published
2016
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75. Memory T cell–driven differentiation of naive cells impairs adoptive immunotherapy

Author

Klebanoff, Christopher A., primary, Scott, Christopher D., additional, Leonardi, Anthony J., additional, Yamamoto, Tori N., additional, Cruz, Anthony C., additional, Ouyang, Claudia, additional, Ramaswamy, Madhu, additional, Roychoudhuri, Rahul, additional, Ji, Yun, additional, Eil, Robert L., additional, Sukumar, Madhusudhanan, additional, Crompton, Joseph G., additional, Palmer, Douglas C., additional, Borman, Zachary A., additional, Clever, David, additional, Thomas, Stacy K., additional, Patel, Shashankkumar, additional, Yu, Zhiya, additional, Muranski, Pawel, additional, Liu, Hui, additional, Wang, Ena, additional, Marincola, Francesco M., additional, Gros, Alena, additional, Gattinoni, Luca, additional, Rosenberg, Steven A., additional, Siegel, Richard M., additional, and Restifo, Nicholas P., additional

Published
2015
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76. Retinoic acid controls the homeostasis of pre-cDC-derived splenic and intestinal dendritic cells

Author

Klebanoff, Christopher A, Spencer, Sean P, Torabi-Parizi, Parizad, Grainger, John R, Roychoudhuri, Rahul, Ji, Yun, Sukumar, Madhusudhanan, Muranski, Pawel, Scott, Christopher D, Hall, Jason A, Ferreyra, Gabriela A, Leonardi, Anthony J, Borman, Zachary A, Wang, Jinshan, Palmer, Douglas C, Wilhelm, Christoph, Cai, Rongman, Sun, Junfeng, Napoli, Joseph L, Danner, Robert L, Gattinoni, Luca, Belkaid, Yasmine, and Restifo, Nicholas P

Subjects
Cell Survival, 1.1 Normal biological development and functioning, Retinoic Acid, Immunology, Tretinoin, Medical and Health Sciences, Immunophenotyping, Vaccine Related, Mice, Underpinning research, Biodefense, Neoplasms, Receptors, Animals, Humans, Homeostasis, Intestinal Mucosa, Vitamin A, Nutrition, Cell Proliferation, Prevention, Inflammatory and immune system, Histocompatibility Antigens Class II, Cell Differentiation, Dendritic Cells, Intestines, Emerging Infectious Diseases, Phenotype, Organ Specificity, Zero Hunger, Female, Digestive Diseases, Spleen, Whole-Body Irradiation, Signal Transduction
Abstract

Dendritic cells (DCs) comprise distinct populations with specialized immune-regulatory functions. However, the environmental factors that determine the differentiation of these subsets remain poorly defined. Here, we report that retinoic acid (RA), a vitamin A derivative, controls the homeostasis of pre-DC (precursor of DC)-derived splenic CD11b(+)CD8α(-)Esam(high) DCs and the developmentally related CD11b(+)CD103(+) subset within the gut. Whereas mice deprived of RA signaling significantly lost both of these populations, neither pre-DC-derived CD11b(-)CD8α(+) and CD11b(-)CD103(+) nor monocyte-derived CD11b(+)CD8α(-)Esam(low) or CD11b(+)CD103(-) DC populations were deficient. In fate-tracking experiments, transfer of pre-DCs into RA-supplemented hosts resulted in near complete conversion of these cells into the CD11b(+)CD8α(-) subset, whereas transfer into vitamin A-deficient (VAD) hosts caused diversion to the CD11b(-)CD8α(+) lineage. As vitamin A is an essential nutrient, we evaluated retinoid levels in mice and humans after radiation-induced mucosal injury and found this conditioning led to an acute VAD state. Consequently, radiation led to a selective loss of both RA-dependent DC subsets and impaired class II-restricted auto and antitumor immunity that could be rescued by supplemental RA. These findings establish a critical role for RA in regulating the homeostasis of pre-DC-derived DC subsets and have implications for the management of patients with immune deficiencies resulting from malnutrition and irradiation.

Published
2013

77. Paths to expansion: Differential requirements of IRF4 in CD8+ T‐cell expansion driven by antigen and homeostatic cytokines.

Author

Lugli, Enrico, Brummelman, Jolanda, Pilipow, Karolina, and Roychoudhuri, Rahul

Abstract

Abstract: Interferon regulatory factor 4 (IRF4) regulates the clonal expansion and metabolic activity of activated T cells, but the precise context and mechanisms of its function in these processes are unclear. In this issue of the European Journal of Immunology, Miyakoda et al. [Eur. J. Immunol. 2018. 48: 1319–1328] show that IRF4 is required for activation and expansion of naïve and memory CD8+ T cells driven by T‐cell receptor (TCR) signaling, but dispensable for memory CD8+ T‐cell maintenance and homeostatic proliferation driven by homeostatic cytokines. The authors show that the function of IRF4 in CD8+ T‐cell expansion is partially dependent upon activation of the PI3K/AKT pathway through direct or indirect attenuation of PTEN expression. These data shed light upon the differential intracellular pathways required for naïve and memory T cells to respond to self‐antigens and/or homeostatic cytokines, and highlight the potential translational relevance of these findings in the context of immune reconstitution such as following allogeneic stem cell transplantation. [ABSTRACT FROM AUTHOR]

Published
2018
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78. The transcription factor c-Myb regulates CD8+T cell stemness and antitumor immunity

Author

Gautam, Sanjivan, Fioravanti, Jessica, Zhu, Wei, Le Gall, John B., Brohawn, Philip, Lacey, Neal E., Hu, Jinhui, Hocker, James D., Hawk, Nga Voong, Kapoor, Veena, Telford, William G., Gurusamy, Devikala, Yu, Zhiya, Bhandoola, Avinash, Xue, Hai-Hui, Roychoudhuri, Rahul, Higgs, Brandon W., Restifo, Nicholas P., Bender, Timothy P., Ji, Yun, and Gattinoni, Luca

Abstract

Stem cells are maintained by transcriptional programs that promote self-renewal and repress differentiation. Here, we found that the transcription factor c-Myb was essential for generating and maintaining stem cells in the CD8+T cell memory compartment. Following viral infection, CD8+T cells lacking Mybunderwent terminal differentiation and generated fewer stem cell–like central memory cells than did Myb-sufficient T cells. c-Myb acted both as a transcriptional activator of Tcf7(which encodes the transcription factor Tcf1) to enhance memory development and as a repressor of Zeb2(which encodes the transcription factor Zeb2) to hinder effector differentiation. Domain-mutagenesis experiments revealed that the transactivation domain of c-Myb was necessary for restraining differentiation, whereas its negative regulatory domain was critical for cell survival. Myboverexpression enhanced CD8+T cell memory formation, polyfunctionality and recall responses that promoted curative antitumor immunity after adoptive transfer. These findings identify c-Myb as a pivotal regulator of CD8+T cell stemness and highlight its therapeutic potential.

Published
2019
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79. Transcriptional repressor ZEB2 promotes terminal differentiation of CD8+ effector and memory T cell populations during infection

Author

Omilusik, Kyla D., primary, Best, J. Adam, additional, Yu, Bingfei, additional, Goossens, Steven, additional, Weidemann, Alexander, additional, Nguyen, Jessica V., additional, Seuntjens, Eve, additional, Stryjewska, Agata, additional, Zweier, Christiane, additional, Roychoudhuri, Rahul, additional, Gattinoni, Luca, additional, Bird, Lynne M., additional, Higashi, Yujiro, additional, Kondoh, Hisato, additional, Huylebroeck, Danny, additional, Haigh, Jody, additional, and Goldrath, Ananda W., additional

Published
2015
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80. Immunotherapy generates selective pressure for acquisition of immunogenic neoantigens in escape tumors

Author

Pan, Jenny H, primary, Vodnala, Suman, additional, Eil, Robert L, additional, Yu, Zhiya, additional, Gartner, Jared J, additional, Clever, David, additional, Roychoudhuri, Rahul, additional, Patel, Shashank J, additional, Klebanoff, Christopher A, additional, Sukumar, Madhusudhanan, additional, Yamamoto, Tori, additional, and Restifo, Nicholas P, additional

Published
2015
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83. Cish actively silences tcr signaling in CD8+ T cells to maintain tumor tolerance

Author

Palmer, Douglas, primary, Guittard, Geoff, additional, Franco, Zulmarie, additional, Patel, Shashank, additional, Klebanoff, Christopher A, additional, Sukumar, Madhusudhanan, additional, Eil, Robert L, additional, Clever, David, additional, Balagopalan, Lakshmi, additional, Roychoudhuri, Rahul, additional, Samelson, Larry, additional, and Restifo, Nicholas, additional

Published
2015
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84. Modulating immunometabolism of tumor specific mouse and human lymphocytes to enhance T cell based therapy for cancer

Author

Sukumar, Madhusudhanan, primary, Liu, Jie, additional, Patel, Shashank J, additional, Klebanoff, Christopher A, additional, Mehta, Gautam, additional, Roychoudhuri, Rahul, additional, Crompton, Joseph, additional, Clever, David, additional, Gattinoni, Luca, additional, Muranski, Pawel, additional, Finkel, Toren, additional, and Restifo, Nicholas, additional

Published
2015
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86. Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance

Author

Palmer, Douglas C., primary, Guittard, Geoffrey C., additional, Franco, Zulmarie, additional, Crompton, Joseph G., additional, Eil, Robert L., additional, Patel, Shashank J., additional, Ji, Yun, additional, Van Panhuys, Nicholas, additional, Klebanoff, Christopher A., additional, Sukumar, Madhusudhanan, additional, Clever, David, additional, Chichura, Anna, additional, Roychoudhuri, Rahul, additional, Varma, Rajat, additional, Wang, Ena, additional, Gattinoni, Luca, additional, Marincola, Francesco M., additional, Balagopalan, Lakshmi, additional, Samelson, Lawrence E., additional, and Restifo, Nicholas P., additional

Published
2015
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88. The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells

Author

Khor, Bernard, primary, Gagnon, John D, additional, Goel, Gautam, additional, Roche, Marly I, additional, Conway, Kara L, additional, Tran, Khoa, additional, Aldrich, Leslie N, additional, Sundberg, Thomas B, additional, Paterson, Alison M, additional, Mordecai, Scott, additional, Dombkowski, David, additional, Schirmer, Melanie, additional, Tan, Pauline H, additional, Bhan, Atul K, additional, Roychoudhuri, Rahul, additional, Restifo, Nicholas P, additional, O'Shea, John J, additional, Medoff, Benjamin D, additional, Shamji, Alykhan F, additional, Schreiber, Stuart L, additional, Sharpe, Arlene H, additional, Shaw, Stanley Y, additional, and Xavier, Ramnik J, additional

Published
2015
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89. Lineage relationship of CD8+ T cell subsets is revealed by progressive changes in the epigenetic landscape

Author

Crompton, Joseph G., primary, Narayanan, Manikandan, additional, Cuddapah, Suresh, additional, Roychoudhuri, Rahul, additional, Ji, Yun, additional, Yang, Wenjing, additional, Patel, Shashank J., additional, Sukumar, Madhusudhanan, additional, Palmer, Douglas C., additional, Peng, Weiqun, additional, Wang, Ena, additional, Marincola, Francesco M., additional, Klebanoff, Christopher A., additional, Zhao, Keji, additional, Tsang, John S., additional, Gattinoni, Luca, additional, and Restifo, Nicholas P., additional

Published
2015
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90. Author response: The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells

Author

Khor, Bernard, primary, Gagnon, John D, additional, Goel, Gautam, additional, Roche, Marly I, additional, Conway, Kara L, additional, Tran, Khoa, additional, Aldrich, Leslie N, additional, Sundberg, Thomas B, additional, Paterson, Alison M, additional, Mordecai, Scott, additional, Dombkowski, David, additional, Schirmer, Melanie, additional, Tan, Pauline H, additional, Bhan, Atul K, additional, Roychoudhuri, Rahul, additional, Restifo, Nicholas P, additional, O'Shea, John J, additional, Medoff, Benjamin D, additional, Shamji, Alykhan F, additional, Schreiber, Stuart L, additional, Sharpe, Arlene H, additional, Shaw, Stanley Y, additional, and Xavier, Ramnik J, additional

Published
2015
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92. Akt Inhibition Enhances Expansion of Potent Tumor-Specific Lymphocytes with Memory Cell Characteristics

Author

Crompton, Joseph G., primary, Sukumar, Madhusudhanan, additional, Roychoudhuri, Rahul, additional, Clever, David, additional, Gros, Alena, additional, Eil, Robert L., additional, Tran, Eric, additional, Hanada, Ken-ichi, additional, Yu, Zhiya, additional, Palmer, Douglas C., additional, Kerkar, Sid P., additional, Michalek, Ryan D., additional, Upham, Trevor, additional, Leonardi, Anthony, additional, Acquavella, Nicolas, additional, Wang, Ena, additional, Marincola, Francesco M., additional, Gattinoni, Luca, additional, Muranski, Pawel, additional, Sundrud, Mark S., additional, Klebanoff, Christopher A., additional, Rosenberg, Steven A., additional, Fearon, Douglas T., additional, and Restifo, Nicholas P., additional

Published
2015
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93. Type I Cytokines Synergize with Oncogene Inhibition to Induce Tumor Growth Arrest

Author

Acquavella, Nicolas, primary, Clever, David, additional, Yu, Zhiya, additional, Roelke-Parker, Melody, additional, Palmer, Douglas C., additional, Xi, Liqiang, additional, Pflicke, Holger, additional, Ji, Yun, additional, Gros, Alena, additional, Hanada, Ken-ichi, additional, Goldlust, Ian S., additional, Mehta, Gautam U., additional, Klebanoff, Christopher A., additional, Crompton, Joseph G., additional, Sukumar, Madhusudhanan, additional, Morrow, James J., additional, Franco, Zulmarie, additional, Gattinoni, Luca, additional, Liu, Hui, additional, Wang, Ena, additional, Marincola, Francesco, additional, Stroncek, David F., additional, Lee, Chyi-Chia R., additional, Raffeld, Mark, additional, Bosenberg, Marcus W., additional, Roychoudhuri, Rahul, additional, and Restifo, Nicholas P., additional

Published
2015
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94. miR-155 augments CD8 + T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic γ c cytokines

Author

Ji, Yun, primary, Wrzesinski, Claudia, additional, Yu, Zhiya, additional, Hu, Jinhui, additional, Gautam, Sanjivan, additional, Hawk, Nga V., additional, Telford, William G., additional, Palmer, Douglas C., additional, Franco, Zulmarie, additional, Sukumar, Madhusudhanan, additional, Roychoudhuri, Rahul, additional, Clever, David, additional, Klebanoff, Christopher A., additional, Surh, Charles D., additional, Waldmann, Thomas A., additional, Restifo, Nicholas P., additional, and Gattinoni, Luca, additional

Published
2014
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95. Identification of the Genomic Insertion Site of Pmel-1 TCR α and β Transgenes by Next-Generation Sequencing

Author

Ji, Yun, primary, Abrams, Natalie, additional, Zhu, Wei, additional, Salinas, Eddie, additional, Yu, Zhiya, additional, Palmer, Douglas C., additional, Jailwala, Parthav, additional, Franco, Zulmarie, additional, Roychoudhuri, Rahul, additional, Stahlberg, Eric, additional, Gattinoni, Luca, additional, and Restifo, Nicholas P., additional

Published
2014
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96. Epigenetic control of CD8+T cell differentiation

Author

Henning, Amanda N., Roychoudhuri, Rahul, and Restifo, Nicholas P.

Abstract

Upon stimulation, small numbers of naive CD8+T cells proliferate and differentiate into a variety of memory and effector cell types. CD8+T cells can persist for years and kill tumour cells and virally infected cells. The functional and phenotypic changes that occur during CD8+T cell differentiation are well characterized, but the epigenetic states that underlie these changes are incompletely understood. Here, we review the epigenetic processes that direct CD8+T cell differentiation and function. We focus on epigenetic modification of DNA and associated histones at genes and their regulatory elements. We also describe structural changes in chromatin organization that affect gene expression. Finally, we examine the translational potential of epigenetic interventions to improve CD8+T cell function in individuals with chronic infections and cancer.

Published
2018
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97. BACH2 represses effector programmes to stabilize Treg-mediated immune homeostasis - a new target in tumor immunotherapy?

Author

Roychoudhuri, Rahul, primary, Hirahara, Kiyoshi, additional, Mousavi, Kambiz, additional, Clever, David, additional, Bonelli, Michael, additional, Klebanoff, Christopher, additional, Sartorelli, Vittorio, additional, Kanno, Yuka, additional, Gattinoni, Luca, additional, Wang, Ena, additional, Liu, Hui, additional, Marincola, Franco, additional, Kazuhiko, Igarashi, additional, O’Shea, John, additional, and Restifo, Nicholas P, additional

Published
2013
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98. Gene-Based Vaccination with a Mismatched Envelope Protects against Simian Immunodeficiency Virus Infection in Nonhuman Primates

Author

Flatz, Lukas, primary, Cheng, Cheng, additional, Wang, Lingshu, additional, Foulds, Kathryn E., additional, Ko, Sung-Youl, additional, Kong, Wing-Pui, additional, Roychoudhuri, Rahul, additional, Shi, Wei, additional, Bao, Saran, additional, Todd, John-Paul, additional, Asmal, Mohammed, additional, Shen, Ling, additional, Donaldson, Mitzi, additional, Schmidt, Stephen D., additional, Gall, Jason G. D., additional, Pinschewer, Daniel D., additional, Letvin, Norman L., additional, Rao, Srinivas, additional, Mascola, John R., additional, Roederer, Mario, additional, and Nabel, Gary J., additional

Published
2012
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99. Permissivity of the NCI-60 cancer cell lines to oncolytic Vaccinia Virus GLV-1h68

Author

Ascierto, Maria Libera, primary, Worschech, Andrea, additional, Yu, Zhiya, additional, Adams, Sharon, additional, Reinboth, Jennifer, additional, Chen, Nanhai G, additional, Pos, Zoltan, additional, Roychoudhuri, Rahul, additional, Di Pasquale, Giovanni, additional, Bedognetti, Davide, additional, Uccellini, Lorenzo, additional, Rossano, Fabio, additional, Ascierto, Paolo A, additional, Stroncek, David F, additional, Restifo, Nicholas P, additional, Wang, Ena, additional, Szalay, Aladar A, additional, and Marincola, Francesco M, additional

Published
2011
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