Search

The synthesis of α,ω-dicarboxylic acids and unsaturated monocarboxylic acids by metal-ion promoted ring-opening of cyclic α-t-butyl-dimethylsilyloxy hydroperoxides has been described.

t-Butyldimethylsilyl enol ethers derived from a wide range of ketones react with hydrogen peroxide in the presence of acid to give remarkably stable α-silyloxyhydroperoxides.

The synthesis of dehydroarachidonic acid derivatives 1-3 is described together with their oxidation by soybean lipoxygenase. The results of these and kinetic studies suggest the occurrence of organoiron intermediates in lipoxygenation.

The Caribbean coral species Plexaura homomalla, Plexaura nina, Plexaura flexuosa, Pseudopterogorgia americana, Muriceopsis flavida , and Eunicea asperula have all been found to convert arachidonate to 8- R -HPETE ( 4 ) and preclavulone-A ( 3 ) demonstrating that this route to marine prostanoids is widespread among such coral.

The possibility of dioxirane formation from thermal and cesium fluoride induced decomposition of α-t-butyldimethylsilyloxyalkyl peroxypenzoates has been examined.

Details de la preparation et des proprietes de polymeres endoperoxydes derives de PVNP substitues par des methyles

Acyclic conjugated allenylphosphine oxide 4b prepared by three step operations was stable at ambient temperature and underwent Bergman type cyclization to form biradical 5b at 37 °C.

12(S)-hydroxyeicosatetraenoic acid methyl ester 1 was synthesized. 1 was converted to phosphite 17 which upon treatment with hydrogen peroxide afforded the corresponding hydroperoxide 18 (12-HPETE methyl ester) with partially retained configuration.