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Abstract Background Autoimmune/type 1 diabetes mellitus (T1DM) is a recently described rare occurrence following the administration of adjuvants such as coronavirus disease 2019 (COVID-19) vaccines. This systematic review aimed to review all available literature on the potential association between COVID-19 vaccines and T1DM. Methods The Directory of Open Access Journals, MEDLINE, Google Scholar, and Scopus were systematically searched for all published studies from inception to July 2022. Articles reporting T1DM development within 8 weeks of administration of COVID-19 vaccine were included. Two reviewers independently performed the risk of bias assessment following the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports. Results Eight eligible studies were retrieved, comprising 12 patients diagnosed with T1DM after being vaccinated with a COVID-19 vaccine. Six patients (50%) reported T1DM after receiving the second dose. Five patients (41.7%) presented with diabetic ketoacidosis, of which four presented within the first eight days after vaccination. Five patients (41.7%) had genetic susceptibility, with RNA binding motif protein 45 (RBM45/DRB1) and major histocompatibility complex, class II, DQ beta 1 (HLA-DQB1) mutations being prominent. Interpretation In this review, we have shown a small number of new-onset diabetes cases coincidently occurring soon after the COVID-19 vaccine, especially in those with genetic susceptibility. Despite being older, these patients had a similar phenotype to T1DM. While there might be a causal relationship between COVID-19 vaccines and T1DM development, this should not influence decisions regarding vaccination since the overall benefit outweighs the risk. Further larger prospective trials are needed to assess causal relationship and to clarify the potential roles of COVID-19 vaccine-derived antigens in autoimmune disease development. Protocol registration PROSPERO-CRD42022342093.

Abstract Background With the advances in neonatal intensive care, the survival rate of extremely preterm infants is increasing. However, bronchopulmonary dysplasia (BPD) remains a major cause of morbidity among infants in this group. This study examined the changes in respiratory support modalities, specifically heated humidified high-flow nasal cannula (HHHFNC), and their association with BPD incidence among preterm infants born at

A facile procedure for extracting and determining seven neonicotinoids was developed. Water was the only extraction solvent without phase separation and cleanup steps. The method was validated according to European Union standards, and the values obtained were compared with the criteria. The accuracy values were between 99.8% (thiamethoxam) and 106.8% (clothianidin) at the spiking levels of 0.01, 0.1, and 1 mg/kg in the tested matrices. The precision as pooled RSD values was ≤6.1% (intra-day) and ≤6.9% (inter-day). The limit of quantification was set and tested at 0.01 mg/kg. The matrix effect was evaluated, and all matrices had a suppressive effect. The matrix of the cucumber was the most effective, with −20.9% for dinotefuran and an average of −9.8% for all compounds, while the tomato matrix had the slightest effect. Real marketed samples were analyzed using the developed and QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) methods; the results were not significantly different. A supervised field trial was conducted in the open field to study the dissipation patterns of imidacloprid and dinotefuran in tomatoes. The dissipation of both compounds followed first-order kinetics. The half-life (T½) values were 3.4 and 2.5 days, with dissipation rates k of 0.2013 and 0.2781 days, respectively. Following the EU-MRL database, the calculated pre-harvest interval (PHI) values were 7 and 14 days for imidacloprid and dinotefuran, respectively, and 3 days for both compounds following Codex Alimentarius regulations. The risk of imidacloprid and dinotefuran residues was estimated from chronic and acute perspectives. The risk factors of dinotefuran were lower than those of imidacloprid. Nonetheless, the highest expected residues of both compounds were below the tolerance limits.

Tetranychus urticae is an important pest of tomato crops globally, affecting plant yield and growth. Beauveria bassiana and Metarhizium robertsii have the potential to control T. urticae. We investigated the influence of two B. bassiana (i.e., WG-12 and WG-19) isolates and one M. robertsii (WG-02) isolate when colonizing different plant organs (leaves, stems, and roots) and their influence on the growth of tomato plants, through foliar, root-dipping, and seed-soaking application techniques. We also examined the acaricidal activity of the three isolates against T. urticae (female adults), spraying tomato leaf discs with each isolate separately. After 28 days, WG-12 and WG-19 colonized 97 and 91% of the leaves after foliar inoculation, whereas WG-02 exhibited the lowest leaf colonization (76%). The height of the tomato plants, the root length, the number of leaves, and the weight of the biomass above and below the ground were enhanced significantly after inoculation with WG-02 vs. B. bassiana isolates and control. The complete mortality of T. urticae was caused by WG-12 and WG-02 after 10 days, whereas WG-19 killed 94% of the adults. For the effective management of T. urticae, we propose the application of the WG-02 isolate since it provides complete protection and promotes the growth of tomato plants.

الملخص: أهداف البحث: للتحقيق في مواقف وتصورات طلاب طب الأسنان حول التعاون / التعليم المهني الداخلي (التعليم الداخلي) والتعلم المشترك واستكشاف تأثير التعليم الداخلي على التطوير الشخصي والمهني للطلاب المشاركين. طرق البحث: تم استخدام استبانة مصمم خصيصا في هذه الدراسة المقطعية. تتكون الاستبانة من سبعة عشر سؤالا يستهدف معرفة تصورات الطلاب حول: 1- تفضيل / رأي طلاب طب الأسنان حول التعليم الداخلي؛ 2- خبرة طلاب طب الأسنان حول تأثير التعليم الداخلي على نتائج التعلم والتطوير المهني؛ 3- ملاحظات الطلاب حول أهمية التعليم الداخلي في مختبرات المحاكاة السريرية وإعدادات مكان العمل. قام الطلاب بتقييم كل من العبارات السبعة عشر على مقياس ليكرت من 5 نقاط (النطاق: 1 = لا أوافق بشدة، 5 = أوافق بشدة). النتائج: تم تحليل ما مجموعه 259 استبانة (معدل الاستجابة = 65٪). كان جميع الطلاب على دراية بالتعليم الداخلي في مجال طب الأسنان (متوسط الدرجة = 4.22). فضل الطلاب التعلم التعاوني / المشترك مع زملائهم في الفصل. كان هناك إجماع بين الطلاب حول التأثير الإيجابي للتعليم الداخلي على التعلم المعزز، وتعزيز مهارات الاتصال، وإثراء العلاقات المهنية مع الموظفين الداعمين وكذلك مع المرضى، وتحسين المهارات التحليلية والنفسية الحركية، وفهم المشاكل المعقدة في العيادات، وفهم نقاط القوة والقيود التي تؤدي إلى تحسين الذات وزيادة الكفاءة والإنتاجية. الاستنتاجات: كان للتعليم الداخلي تأثير مقنع وقوي وإيجابي وفقا لتجربة طلاب طب الأسنان المشاركين في الدراسة. يوصى بتصميم منهج موحد ووضع مبادئ توجيهية لـلتعليم الداخلي في مؤسسات طب الأسنان من أجل التفاعل الفعال بين المتعلمين في جميع المراحل. Abstract: Objectives: To investigate dental students’ attitudes and perceptions about intraprofessional collaboration/education (IPC/IPE) and shared learning, and to explore the impact of IPC/IPE on the personal and professional development of participating students. Methods: A custom-designed questionnaire was used in this cross-sectional study. The questionnaire comprised 17 questions targeting to capture the student's perceptions about IPC/IPE using three factors: (1) dental students' preference/opinion about the IPC/IPE; (2) dental students' experience about the impact of IPC/IPE on learning outcomes and professional development; and (3) students' feedback about the significance of IPC/IPE in clinical/clinical simulation labs and workplace setting. The students rated each of the 17 statements on the 5-point Likert scale (range: 1 = strongly disagree to 5 = strongly agree). Results: A total of 259 responses were analysed (response rate = 65%). All students were aware of IPC/IPE in the field of dentistry (mean score = 4.22). The students preferred collaborative/shared learning with their own classmates. There was a consensus among students about the positive impact of IPC/IPE on enhanced learning, enhancement of communication skills, and enrichment of professional relationships with supporting staff as well as with the patients. There was also improved analytical and psychomotor skills, understanding of complex problems in the clinic, and understanding of strengths and limitations leading to self-improvement and increased efficiency and productivity. Conclusion: IPC/IPE had a compelling, powerful, and positive impact according to the experience of the participating dental students. It is recommended that a standardized curriculum be designed and guidelines set for IPC/IPE at dental institutions for effective interactions among students of all stages.

Stomas are essential for colorectal surgery and are widely used not only for selected cases for bowel obstructions but also in rectal cancer operations to divert stool away from low rectal anastomosis. On the other hand, complications with stomas/ stomas reversal are not uncommon. In this study, we aimed at studying the frequency and the predictors of temporary stomas being permanent, and the contributing factors of surgical stoma/stoma closure related complications. In our cohort, only about 40% of the patient closed their initially planned temporary stomas. The occurrence of intestinal leak, wound sepsis, or any type of morbidity with 30 days of operation were significant predictors of permanent stomas. In addition, alarmingly although Hartmann's procedure was uncommon in our practice, only 9% of those who underwent Hartmann's have had it reversed. Moreover, the only factor that significantly increased stoma related complications was having an end colostomy. There was a tendency toward late closure of stomas with median 8.2 months, however early closure did not correlate to complications. In conclusion, further studies are needed to delineate the low rate of stoma closure. Patients who develop postoperative complications, even wound sepsis, would be at a higher risk of living with permanent stomas. Hartmann's procedures are commonly associated with stoma problems, and reluctance to reverse the stomas.

Abstract Hepatocellular carcinoma (HCC) is the commonest malignancy in Egypt secondary to endemic hepatitis virus. Dual malignancy with HCC is infrequently reported. We herein retrospectively collected data of HCC patients with another primary tumor from a tertiary cancer center. Fifteen patients were enrolled in this case series, epidemiologic data, type of second malignancy, time interval between both tumors, treatment applied, and pattern of recurrence and survival are displayed. Third of the tumors were synchronous, while in the rest HCC was mostly the second malignancy. Breast cancer was the commonest encountered other primary. None of the second malignancies recurred after treatment except for prostate cancer which was not treated radically. The median overall survival of the patients was shorter than previously published series about 29 months. In conclusion, dual malignancy with HCC had more complicated treatment panels; however, they are not necessarily carrying a worse prognosis. HCC tumor outcome remains the main predictor of survival.

Abstract Water quality index (WQI) of Narora channel and health of endemic fish Bagarius bagarius and plant Eichhornia crassipes, district Bulandshahar, Uttar Pradesh, India were studied. Among the physicochemical properties of water, pH, D.O, Cr, Fe, Ni, and Cd were above the recommended standards. These factors lead to high WQI (4124.83), indicating poor quality and not suitable for drinking and domestic usage. In fish tissues, the highest metal load was reported in the liver (58.29) and the lowest in the kidney (33.73). Heavy metals also cause a lowering of condition indices. As expected, decreased serum protein (− 63.41%) and liver glycogen (− 79.10%) were recorded in the exposed fish. However, blood glucose (47.22%) and serum glycogen (74.69%) showed elevation. In the plant, roots (21.50) contained the highest, and leaves (16.87) had the lowest heavy metal load. Bioaccumulation factor (BAF) > 1, indicates hyperaccumulation of all metals. E. crassipes roots showed the highest translocation factor (TF) > 1 for Ni (1.57) and Zn (1.30). The high mobility factor (MF) reflected the suitability of E. crassipes for phytoextraction of Mn, Cd, Zn, Fe, Ni, and Cu. Moreover, Bagarius sp. consumption could not pose any non-cancer risk. Although, lower cancer risk can be expected from Ni and Cr.

A donor–acceptor substituted derivative 2,6-diamino-4-(3,4,5-trimethoxy-phenyl)-pyridine-3,5-dicarbonitrile (DTPP) has been synthesized and its photophysical properties have been studied. Effect of solvent on the photophysical features of DTPP has been undertaken by steady state absorption and emission techniques. Strong solvatochromic emission has been observed due to intramolecular charge transfer characteristics, upon changing the solvent polarity, revealing the highly polar character of the excited state. Dipole moment changes between the excited and ground state have been estimated by using the theory of solvatochromism from Lippert–Mataga and Reichardt’s correlations. The geometrical parameters for ground and excited states, conformational flexibility, and NLO behavior of the molecule have been theoretically investigated. The electronic distributions of DTPP in HOMO and LUMO were also investigated using density functional theory (DFT) methods at B3LYP/6-31 G** level. The correlation of experimental results with theoretical predictions obtained via DFT substantiates the presence of polarity dependent of the emission spectra.

Introduction Recently, Saudi Arabia has extensively reformed its tobacco control policies and extended its smoking cessation services. A public outrage on social media among smokers was witnessed, especially after the implementation of plain cigarette packaging, which might have discredited the significant efforts of tobacco treatment services and tobacco control policies. However, it is not known how the credibility of the tobacco control regulatory body among Saudi smokers might affect their smoking behavior. Methods Saudi tobacco smokers (n=511) were recruited using a convenience sampling technique. A cross-sectional survey was conducted comprising questions related to the credibility of the tobacco control regulatory body (modified Food and Drug Administration Tobacco Credibility Scale), quit attempts, use of nicotine replacement therapy (NRT), and motivation to change smoking behavior in the future. Logistic and linear regression models were used for the analysis. Results The public interest subscale of the credibility of the tobacco control regulatory body, was positively associated with confidence in changing smoking behavior (β=0.204; 95% CI: 0.078–0.713; t=2.449, p=0.015) and readiness to change smoking behavior (β=0.237; 95% CI: 0.127–0.727; t=2.802, p=0.005). Moreover, the subscale of expertise was positively associated with confidence in changing smoking behavior (β=0.190; 95% CI: 0.006–0.697; t=1.999, p=0.046) and readiness to change smoking behavior (β=0.225; 95% CI: 0.063–0.710; t=2.352, p=0.019). However, public interest in the credibility of the tobacco control regulatory body was negatively associated with NRT use among smokers who tried to quit (adjusted odds ratio, AOR=0.691; 95% CI: 0.526–0.909). The credibility of the tobacco control regulatory body, however, was not associated with the last month’s or ever quit attempts. Conclusions The credibility of the tobacco control regulatory body was positively associated with motivation to change smoking behavior but negatively associated with NRT use. Optimizing communication tools with the public is a potential avenue for improving smoking treatment and prevention in Saudi Arabia.

Left ventricular hypertrophy is a common entity with a broad differential diagnosis. We present a case of a middle-aged woman with left ventricular hypertrophy and neuropathy caused by a rare transthyretin variant in the absence of a family history or regional reports of hereditary transthyretin amyloidosis. This report outlines the diagnosis and management of patients with a mixed phenotype of hereditary transthyretin amyloidosis and enriches clinical data supporting the pathogenicity of a rare variant of transthyretin. Résumé: L’hypertrophie ventriculaire gauche est une entité clinique fréquente pour laquelle le diagnostic différentiel est vaste. Nous décrivons le cas d’une femme d’âge moyen présentant une hypertrophie ventriculaire gauche et une neuropathie, causées par un variant rare de la transthyrétine en l’absence d’antécédents familiaux ou de cas régionaux déclarés d’amylose héréditaire à transthyrétine. Le présent article décrit le diagnostic et la prise en charge des patients qui présentent un phénotype mixte d’amylose héréditaire à transthyrétine, et il alimente le bassin de données cliniques sur la pathogénicité d’un variant rare de la transthyrétine.

This paper focuses on the analysis of a coupled system governed by a Caputo-fractional derivative with q-integral-coupled boundary conditions. This system is particularly relevant in modeling multi-atomic systems, including scenarios involving adsorbed atoms or clusters on crystalline surfaces, surface–atom scattering, and atomic friction. To investigate this system, we introduce an operator that exhibits fixed points corresponding to the solutions of the problem, effectively transforming the system into an equivalent fixed-point problem. We established the necessary conditions for the existence and uniqueness of solutions using the Leray–Schauder nonlinear alternative and the Banach contraction mapping principle, respectively. Stability results in the Ulam sense for the coupled system are also discussed, along with a sensitivity analysis of the range parameters. To support the validity of their findings, we provide illustrative examples. Overall, the paper offers a thorough examination and analysis of the considered coupled system, making important contributions to the understanding of multi-atomic systems and their mathematical modeling.

In current study the pharmaceutically active herbs was used against coccidiosis, caused by a protozoan: Eimeria, lead to $ 3 billion loss annually. The aqueous and methanolic extracts of whole plants were applied in-vitro to assess sporulation inhibition (spi) assay and calculated the inhibitory concentration (IC50). For in-vivo study 9 groups of 14 day old broiler chicks were infected with Eimeria tenella and three groups were treated different concentrations of methanolic extracts of Verbena officinalis and Polygonum glabrum post infection. The mean weight gain, oocyst count, diarrhea, biochemical tests, hematology, and histopathology of all groups were analyzed. The herbs were characterized by antioxidant assay, phytochemical screening, Fourier transmission and infrared (FT-IR), Ultra Violet-visible (UV–Vis) spectroscopy and Gas chromatography and mass spectroscopy (GC–MS). The GC–MS identified phyto-compounds of V. officinalis were docked with S-Adenosyl methionine (SAM) synthetase. The in-vitro study revealed that V. officinalis and P. glabrum have minimum IC50 of 0.14 and 12 mg/ml respectively. The in-vivo experiment showed that V. officinalis had significantly high anticoccidial potential with significant hematological profile like drug treated controls. The histology of treated chicks also showed recovery in the studied tissues. The antioxidant assay showed that V. officinalis have 4.19U/mg Superoxide dismutase (SOD) and 33.96 µM/mg Glutathione (GSH) quantities. The chemical characterization confirmed the presence of large number of organic compounds, however Flavonoids found only in V. officinalis, which suggests the anticoccidial potential of V. officinalis because flavonoids as antagonist of thiamine (Prinzo, 1999), because it promotes the carbohydrate synthesis required. Strychane, 1-acetyl-20a-hydroxy-16-methylene has best binding of with target protein with lowest binding score (-6.4 Kcal/mol), suggests its anticoccidial potential in poultry.

BACKGROUND: Indoor and ambient air pollution exposure is a major risk to respiratory health worldwide, particularly in low- and middle-income countries (LMICs). Interventional trials have mainly focused on alternatives to cooking stoves, with mixed results. Beyond cooking, additional sources of particulate matter also contribute to the burden of air pollution exposure. This review explores evidence from current randomised controlled trials (RCTs) on the clinical effectiveness of interventions to reduce particulate matter in LMICs.METHODS: Twelve databases and the grey literature (e.g., Government reports and policy papers) were searched. Eligible studies were RCTs conducted in LMICs aiming to reduce particulate exposure from any source and reporting on at least one clinical respiratory outcome (respiratory symptoms, lung function or clinical diagnoses). Data from relevant studies were systematically extracted, the risk of bias assessed and narrative synthesis provided.RESULTS: Of the 14 included studies, 12 tested 'improved' cookstoves, most using biomass, but solar and bioethanol cookers were also included. One trial used solar lamps and another was an integrated intervention incorporating behavioural and environmental components for the treatment and prevention of chronic obstructive pulmonary disease. Of the six studies reporting child pneumonia outcomes, none demonstrated significant benefit in intention-to-treat analysis. Ten studies reported respiratory symptom outcomes with some improvements seen, but self-reporting made these outcomes highly vulnerable to bias. Substantial inter-study clinical and methodological heterogeneity precluded calculation of pooled effect estimates.CONCLUSION: Evidence from the RCTs performed to date suggests that individual household-level interventions for air pollution exposure reduction have limited benefits for respiratory health. More comprehensive approaches to air pollution exposure reduction must be developed so their potential health benefits can be assessed.

الملخص: أهداف البحث: تأثرت الخدمات الطبية ودخول المستشفى الاختياري بجائحة فيروس كورونا. حاولت تخصصات متعددة دراسة تأثير الوباء على خدماتهم. نهدف إلى دراسة تأثير هذا الوباء على خدمة جراحة الأعصاب في مستشفى جامعة الملك عبد العزيز بجدة على مدى ثمانية أشهر. طرق البحث: في هذه الدراسة الاستعادية لسلسلة الحالات من مركز واحد، قمنا بتضمين جميع مرضى جراحة الأعصاب الذين خضعوا لتدخل جراحي من 3 مارس 2020 إلى 3 نوفمبر 2020 لمدة 8 أشهر. تم جمع البيانات الديموغرافية للمرضى، والتشخيص، ونوع الجراحة، وفئة الأولوية، وبيانات الوفيات. النتائج: خضعت 147 حالة لعملية جراحية خلال فترة الدراسة. كان متوسطالعمر 30.8 سنة. كان 49% من مجتمع الدراسة من الرجال. كانت حالات الأورام وموه الرأس أعلى عدد من الحالات بنسبة 31.3٪ و 23.8٪ على التوالي. وكان أكثر من نصف الحالات قضايا ذات الأولوية الأولى (عاجلة وخلال 24 ساعة). وبلغ معدل الوفيات 4.1٪ بين الحالات التي تم إجراؤها. الاستنتاجات: من خلال وصف هذه التجربة في جراحة الأعصاب المحلية أثناء جائحة كوفيد-19، نأمل في إظهار بعض الصعوبات التي واجهناها، وتحسين ما تعلمناه خلال الوباء الحالي. Abstract: Objective: The coronavirus disease 2019 (COVID-19) pandemic affected both medical services as well as hospital admissions. Scholars have attempted to study the effect of the pandemic on the services of multiple specialities. In this study, we aim to examine the pandemic's impact on the neurosurgical service provided at the King Abdulaziz University Hospital in Jeddah over an eight-month period. Methods: In this retrospective, single-centre case series study, we included all the consecutive neurosurgical patients who underwent a surgical intervention in the 8-month period starting on 3rd March, 2020 and ending on 3rd November, 2020. The demographics, diagnosis, surgery type, priority category, and mortality data of the patients were collected. Results: A total of 147 patients underwent surgery during the study period. The mean age was 30.8 years. Forty-nine percent of the study population were men. Oncology (31.3%) and hydrocephalus (23.8%) recorded the highest number of cases. More than half of the cases were Priority 1 (immediate and within 24 h). The mortality rate was 4.1% among all the performed cases. Conclusion: By describing this local neurosurgical experience during the COVID-19 pandemic, we hope to bring out some of the difficulties we encountered and improve what we learned during the pandemic.

Objective To investigate physicians’ perceptions and current practices of identifying and managing depression in patients with chronic obstructive pulmonary disease (COPD).Design A cross-sectional online survey was employed between March and September 2022.Settings Saudi Arabia.Participants 1015 physicians, including general practitioners and family, internal and pulmonary medicine specialists.Primary outcome measures Physicians’ perceptions, confidence, practices and barriers to recognising and managing depression in patients with COPD.Results A total of 1015 physicians completed to the online survey. Only 31% of study participants received adequate training for managing depression. While 60% of physicians reported that depression interferes with self-management and worsens COPD symptoms, less than 50% viewed the importance of regular screening for depression. Only 414 (41%) physicians aim to identify depression. Of whom, 29% use depression screening tools, and 38% feel confident in discussing patients’ feelings. Having adequate training to manage depression (OR: 2.89; 95% CI: 2.02 to 3.81; p