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54. Prognostic significance of incorporating exercise tissue doppler mitral annular early diastolic velocity in exercise diastolic dysfunction assessment

Author

Alaa Mabrouk Salem Omar, Swiri Konje, Alba Muñoz‐Estrella, Loba Alam, Kruti Gandhi, Errol Moras, Brissete Mancero, Arpanjeet Kaur, Elizabeth Zipf, David Meister, Maria Peña, Christopher Perez‐Lizardo, Ga Hee Kim, Joseph Elias, and Edgar Argulian

Subjects
Radiology, Nuclear Medicine and imaging, Cardiology and Cardiovascular Medicine
Published
2023

56. Critical analysis and evaluation of interactive and customised applications on mobile television : interactive and customised mobile television applications are evaluated using the views of consumers, advertisers, and telecommunications operators with regard to services and also assessing the usability of mobile devices

Author

Al Sheik Salem, Omar fuad abed al whab, Earnshaw, Rae A., and Robison, David J.

Subjects
621.388, Mobile television, User-generated content, HCI, Infotainment, Product placement, Personalised advertising, Regulations, Non-commercial advertising, Human-mobile interaction, Mobile devices
Abstract

The shift of media from traditional forms to new digital ones has raised the possibility of new kinds of media services, including mobile television. In today's communications market, mobile phones are of increasing importance to users and, since mobile devices are connected most of the time, they have a high degree of location independence. The availability of 3G technology and the mobile devices needed to implement mobile television are now established and available. Mobile television is expected to be an important new service that could penetrate the market place and provide new applications, as well as create a market for new players and new investments, if the appropriate price, content and philosophy for content design are found. This research explores the many potential application areas for mobile TV, with a particular focus on advertising. Various organisations that seek success in this market can utilise the potential for advertising on mobile TV. Ultimately, mobile device users are able to use mobile TV for entertainment and information sourcing. However, a number of challenging issues remain to be addressed. The features that appealed to the consumers were studied in this research. Surveys were conducted to obtain an understanding of consumers' opinions and needs regarding the mobile TV experience. Many users clearly do like to interact with video content on mobile devices. Interactive mobile TV advertising can benefit users who will be able to use an essentially 'free' mobile TV service, funded by an advertising model. This research proposes an environment for interactive advertising on mobile TV and discussion of an implementation of the proposed designs.

Published
2011

58. Comparison of transesophageal and transthoracic echocardiography under moderate sedation for guiding transcatheter aortic valve replacement

Author

Ines Sherifi, Alaa Mabrouk Salem Omar, Mithun Varghese, Menachem Weiner, Ani Anyanwu, Jason C Kovacic, Samin Sharma, Annapoorna Kini, and Partho P Sengupta

Subjects
transcatheter aortic valve replacement, transesophageal echocardiography, aortic stenosis, transthoracic echocardiography, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

The optimal periprocedural imaging strategy during transcathether aortic valve replacement (TAVR) performed under moderate sedation is debated. Transthoracic echocardiography (TTE) provides suboptimal views due to poorer resolution and patient positioning, whereas use of transesophageal echocardiography (TEE) under moderate sedation is not widely utilized. The aim of our study was to compare the value of TTE in comparison with TEE guidance under moderate sedation during TAVR. The study population included 144 consecutive patients (mean age 83 ± 11 years, 78 (54%) females) who had TAVR under moderate sedation using either a TTE (n = 96) or TEE (n = 48). We compared procedural outcomes using propensity score matching. There were no significant inter-group differences in age, sex, ejection fraction, aortic valve area, pressure gradients, creatinine or type of valve used. The procedural time was significantly shorter in the TEE group (P < 0.001) and associated with a lower need for periprocedural aortograms (7.7 ± 1.9 vs 8.2 ± 1.9, P = 0.022) and a lower occurrence of acute kidney injury (1 vs 11, P = 0.047). The 1:1 propensity score matching also showed a lower procedural time (P = 0.032), number of aortograms (P = 0.014) and a trend toward lower acute kidney injury in the TEE group (P = 0.077). TAVR guidance using TEE is associated with a lower fluoroscopic time, a lower need for additional aortograms and trend in lower occurrence of post-TAVR acute kidney injury.

Published
2018
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59. NODE DENSITY IMPACT ON ENERGY AND CONTACT OF OPPORTUNISTIC NETWORK

Author

Salem Omar Sati, Abubaker Alhutaba, and Mohamed Eshtawie

Subjects
Opportunistic Communication, Contact Probability, Beacon Interval, Energy Consumption, Node Density, Information technology, T58.5-58.64, Electronic computers. Computer science, QA75.5-76.95
Abstract

Opportunistic communication between two encountered nodes is commonly established using a radio technology such as Wi-Fi or Bluetooth. One issue involved in the opportunistic communication is a trade-off between the connection time and probability with resource consumption. This paper includes a comprehensive study of density analyze for decentralized distributed opportunistic communications using Wi-Fi technology. We study and analyze the contact probability and energy efficiency of variant density in particular area. The contribution of this paper is to analyze the impact of density on the connection probability and resources. Furthermore, we present a simulation study framework to analyze the contact event with a view of energy consumption, the study gives a detailed contact information such as contact probability based on node density and transmission range in particular area, also, the beacon exchange process as an element of channel utilization and energy consumption. We present influence evaluation of various parameters on each other and finally on the system performance.

Published
2018
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60. Scalable querying of human cell atlases via a foundational model reveals commonalities across fibrosis-associated macrophages

Author

Heimberg, Graham, primary, Kuo, Tony CY, additional, DePianto, Daryle, additional, Heigl, Tobias, additional, Diamant, Nathaniel, additional, Salem, Omar, additional, Scalia, Gabriele, additional, Biancalani, Tommaso, additional, Rock, Jason, additional, Turley, Shannon, additional, Bravo, Héctor Corrada, additional, Kaminker, Josh, additional, Vander Heiden, Jason A, additional, and Regev, Aviv, additional

Published
2023
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62. Ca 2 Lib : Simple and Accurate LiDAR-RGB Calibration Using Small Common Markers.

Author

Giacomini, Emanuele, Brizi, Leonardo, Di Giammarino, Luca, Salem, Omar, Perugini, Patrizio, and Grisetti, Giorgio

Subjects
VISUAL perception, LIDAR, CALIBRATION
Abstract

Modern visual perception techniques often rely on multiple heterogeneous sensors to achieve accurate and robust estimates. Knowledge of their relative positions is a mandatory prerequisite to accomplish sensor fusion. Typically, this result is obtained through a calibration procedure that correlates the sensors' measurements. In this context, we focus on LiDAR and RGB sensors that exhibit complementary capabilities. Given the sparsity of LiDAR measurements, current state-of-the-art calibration techniques often rely on complex or large calibration targets to resolve the relative pose estimation. As such, the geometric properties of the targets may hinder the calibration procedure in those cases where an ad hoc environment cannot be guaranteed. This paper addresses the problem of LiDAR-RGB calibration using common calibration patterns (i.e., A3 chessboard) with minimal human intervention. Our approach exploits the flatness of the target to find associations between the sensors' measurements, leading to robust features and retrieval of the solution through nonlinear optimization. The results of quantitative and comparative experiments with other state-of-the-art approaches show that our simple schema performs on par or better than existing methods that rely on complex calibration targets. [ABSTRACT FROM AUTHOR]

Published
2024
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63. Influence of concrete cracking in isolated RC footings on cohesive soil--structure interaction.

Author

Fouda, Mohamed Attia, Salem, Omar, Attia, Rasha, and Ibrahim, Amr

Subjects
CRACKING of concrete, CRACKS in reinforced concrete, CONCRETE footings, SOIL cohesion, STRESS concentration, COHESION
Abstract

One of the aspects that affect structure stability is the soil--structure interaction. A good example of this interaction can be witnessed in footings, in which the properties of the soil surrounding the structural parts and the structural parts themselves affect the engineering behavior of the interaction between concrete footings and the soil. Contact stress distribution represents such interaction. However, contact stress distribution beneath concrete footings does not solely rely on the soil type and behavior of footing in working limit state, but also on the variation in the concrete footings stiffness after cracking. The main purpose of this research is to investigate the effect of the reduction in the concrete footing stiffness due to cracking on the contact stress distribution beneath concentric isolated footings resting on cohesive soil. In this respect, numerical simulation and validation was carried out using a non-linear finite element program 'Abaqus'. A parametric study was conducted to extend this study by including soil cohesion, internal friction angle, rebars yield strength, and foundation depth as investigated parameters. The concrete foundation behavior and failure mode were analyzed. The findings of this research indicate that the different variations of cracks in reinforced concrete showed different shapes of contact stress distribution. [ABSTRACT FROM AUTHOR]

Published
2024
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64. Blind color user interface requirements: A UMI specification.

Author

Abed, Waed Abu, Salem, Omar Al Sheik, and Ghoul, Said

Subjects
*COLOR blindness, *USER interfaces, *ELICITATION technique, *REQUIREMENTS engineering
Abstract

Color blindness, or color vision deficiency, is an inability to see the difference between certain colors. Men are more likely to be born with color blindness. Most people with color blindness can't distinguish between certain shades of red and green. Less commonly, people with color blindness can't distinguish between shades of blue and yellow. For that it's a significant barrier to effective computer use. Several research works dealing with blind color user interfaces are currently conducted. However, requirements engineering for such interfaces is still missing. The work presented in this paper is part of an automated blind color user interface generation project which explores suitable input requirements document notations, simplifies the generating process, and outputs generated color blind user interface. It aims to define functional and nonfunctional requirements for powerful color-blind user interface and their UML specification. Thus, different recent techniques that deal with these interfaces are selected according to their relevance and up to date, then they are analyzed, the lack of requirements engineering for these interfaces was stated, and a solution is proposed. It consists of requirements elicitation and specification with UML notations. A case study evaluating the proposed approach is presented. The obtained results confirm the power and positive impact of such requirements engineering on research in this domain. [ABSTRACT FROM AUTHOR]

Published
2023
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65. AR Activates YAP/TAZ Differentially In Prostate Cancer

Author

Salem, Omar, Jia, Siyang, Qian, Bin-Zhi, and Hansen, Carsten Gram

Abstract

The Hippo signalling pathway is a master regulator of cell growth, proliferation, and cancer. The transcriptional coregulators of the Hippo pathway, YAP and TAZ are central in various cancers. However how YAP and TAZ gets activated in most types of cancers are not well understood. Here we show that androgens activate YAP/TAZ via the Androgen Receptor (AR) in prostate cancer (PCa), and that this activation is differential. AR regulates YAP translation, while inducing transcription of the TAZ encoding gene, WWTR1. Further, we show that AR mediated YAP/TAZ activation is regulated by the RhoA GTPases transcriptional mediator, Serum Response Factor (SRF). Importantly, in prostate cancer patients SRF expressionpositively correlates with TAZ, and the YAP/TAZ target genes CYR61 and CTGF. We demonstrate that YAP/TAZ are not essential for sustaining AR activity, however, targeting YAP/TAZ or SRF sensitize PCa cells to AR inhibition in anchorage independent growth conditions. Our findings dissect the cellular roles of YAP, TAZ and SRF in prostate cancer cells. Our data emphasize the interplay between these transcriptional regulators and their roles in prostate tumorigenesis and highlights how these insights might be exploited therapeutically.

Published
2023

66. Clinical features, etiologies, and outcomes in adult patients with meningoencephalitis requiring intensive care (EURECA): an international prospective multicenter cohort study

Author

Sonneville, R, de Montmollin, E, Contou, D, Ferrer, R, Gurjar, M, Klouche, K, Sarton, B, Demeret, S, Bailly, P, da Silva, D, Escudier, E, Le Guennec, L, Chabanne, R, Argaud, L, Ben Hadj Salem, O, Thyrault, M, Frerou, A, Louis, G, De Pascale, G, Horn, J, Helbok, R, Geri, G, Bruneel, F, Martin-Loeches, I, Taccone, F, De Waele, J, Ruckly, S, Staiquly, Q, Citerio, G, Timsit, J, Sonneville, Romain, de Montmollin, Etienne, Contou, Damien, Ferrer, Ricard, Gurjar, Mohan, Klouche, Kada, Sarton, Benjamine, Demeret, Sophie, Bailly, Pierre, da Silva, Daniel, Escudier, Etienne, Le Guennec, Loic, Chabanne, Russel, Argaud, Laurent, Ben Hadj Salem, Omar, Thyrault, Martial, Frerou, Aurélien, Louis, Guillaume, De Pascale, Gennaro, Horn, Janneke, Helbok, Raimund, Geri, Guillaume, Bruneel, Fabrice, Martin-Loeches, Ignacio, Taccone, Fabio Silvio, De Waele, Jan J, Ruckly, Stéphane, Staiquly, Quentin, Citerio, Giuseppe, Timsit, Jean-François, Sonneville, R, de Montmollin, E, Contou, D, Ferrer, R, Gurjar, M, Klouche, K, Sarton, B, Demeret, S, Bailly, P, da Silva, D, Escudier, E, Le Guennec, L, Chabanne, R, Argaud, L, Ben Hadj Salem, O, Thyrault, M, Frerou, A, Louis, G, De Pascale, G, Horn, J, Helbok, R, Geri, G, Bruneel, F, Martin-Loeches, I, Taccone, F, De Waele, J, Ruckly, S, Staiquly, Q, Citerio, G, Timsit, J, Sonneville, Romain, de Montmollin, Etienne, Contou, Damien, Ferrer, Ricard, Gurjar, Mohan, Klouche, Kada, Sarton, Benjamine, Demeret, Sophie, Bailly, Pierre, da Silva, Daniel, Escudier, Etienne, Le Guennec, Loic, Chabanne, Russel, Argaud, Laurent, Ben Hadj Salem, Omar, Thyrault, Martial, Frerou, Aurélien, Louis, Guillaume, De Pascale, Gennaro, Horn, Janneke, Helbok, Raimund, Geri, Guillaume, Bruneel, Fabrice, Martin-Loeches, Ignacio, Taccone, Fabio Silvio, De Waele, Jan J, Ruckly, Stéphane, Staiquly, Quentin, Citerio, Giuseppe, and Timsit, Jean-François

Abstract

Purpose: We aimed to characterize the outcomes of patients with severe meningoencephalitis requiring intensive care. Methods: We conducted a prospective multicenter international cohort study (2017–2020) in 68 centers across 7 countries. Eligible patients were adults admitted to the intensive care unit (ICU) with meningoencephalitis, defined by an acute onset of encephalopathy (Glasgow coma scale (GCS) score ≤ 13), a cerebrospinal fluid pleocytosis ≥ 5 cells/mm3, and at least two of the following criteria: fever, seizures, focal neurological deficit, abnormal neuroimaging, and/or electroencephalogram. The primary endpoint was poor functional outcome at 3 months, defined by a score of three to six on the modified Rankin scale. Multivariable analyses stratified on centers investigated ICU admission variables associated with the primary endpoint. Results: Among 599 patients enrolled, 589 (98.3%) completed the 3-month follow-up and were included. Overall, 591 etiologies were identified in those patients which were categorized into five groups: acute bacterial meningitis (n = 247, 41.9%); infectious encephalitis of viral, subacute bacterial, or fungal/parasitic origin (n = 140, 23.7%); autoimmune encephalitis (n = 38, 6.4%); neoplastic/toxic encephalitis (n = 11, 1.9%); and encephalitis of unknown origin (n = 155, 26.2%). Overall, 298 patients (50.5%, 95% CI 46.6–54.6%) had a poor functional outcome, including 152 deaths (25.8%). Variables independently associated with a poor functional outcome were age > 60 years (OR 1.75, 95% CI 1.22–2.51), immunodepression (OR 1.98, 95% CI 1.27–3.08), time between hospital and ICU admission > 1 day (OR 2.02, 95% CI 1.44–2.99), a motor component on the GCS ≤ 3 (OR 2.23, 95% CI 1.49–3.45), hemiparesis/hemiplegia (OR 2.48, 95% CI 1.47–4.18), respiratory failure (OR 1.76, 95% CI 1.05–2.94), and cardiovascular failure (OR 1.72, 95% CI 1.07–2.75). In contrast, administration of a third-generation cephalosporin (OR 0.54, 95% CI 0.37–0.

Published
2023

67. Association Between Sacubitril/Valsartan Initiation and Mitral Regurgitation Severity in Heart Failure With Reduced Ejection Fraction: The PROVE-HF Study

Author

James L. Januzzi, Alaa Mabrouk Salem Omar, Yuxi Liu, Sean Murphy, Javed Butler, G. Michael Felker, Iliana L. Piña, Jonathan Ward, Scott Solomon, and Johanna Contreras

Subjects
Heart Failure, Drug Combinations, Angiotensin Receptor Antagonists, Aminobutyrates, Physiology (medical), Biphenyl Compounds, Humans, Mitral Valve Insufficiency, Valsartan, Tetrazoles, Stroke Volume, Cardiology and Cardiovascular Medicine, Ventricular Function, Left
Published
2022

68. Immune checkpoint inhibitor-related myositis and myocarditis in patients with cancer

Author

Touat, Mehdi, Maisonobe, Thierry, Knauss, Samuel, Ben Hadj Salem, Omar, Hervier, Baptiste, Auré, Karine, Szwebel, Tali-Anne, Kramkimel, Nora, Lethrosne, Claire, Bruch, Jean-Frédéric, Laly, Pauline, Cadranel, Jacques, Weiss, Nicolas, Béhin, Anthony, Allenbach, Yves, Benveniste, Olivier, Lenglet, Timothée, Psimaras, Dimitri, Stenzel, Werner, and Léonard-Louis, Sarah

Published
2018
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74. Risk Factors of AKI in Acute Respiratory Distress Syndrome: A Time-Dependent Competing Risk Analysis on Severe COVID-19 Patients

Author

Marchiset, Antoine, primary, Serazin, Valerie, additional, Ben Hadj Salem, Omar, additional, Pichereau, Claire, additional, Lima Da Silva, Lionel, additional, Au, Siu-Ming, additional, Barbier, Christophe, additional, Loubieres, Yann, additional, Hayon, Jan, additional, Gross, Julia, additional, Outin, Herve, additional, and Jamme, Matthieu, additional

Published
2023
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75. Worsening of left ventricular twist mechanics in isolated rheumatic mitral stenosis immediately after balloon mitral valvuloplasty

Author

Osama Rifaie, Mohamed Ahmed Abdel-Rahman, Sameh Samir, Khalid Z. Malik, and Alaa Mabrouk Salem Omar

Subjects
Mitral stenosis, Myocardial twist mechanics, Left ventricular dysfunction, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background: Reportedly, left ventricular (LV) mechanics are worsened in patients with mitral stenosis (MS) compared to controls. The immediate effect of balloon mitral valvuloplasty (BMV) on LV mechanics is, however, not known. Aim: To assess the immediate effect of balloon mitral valvuloplasty on the left ventricular twist mechanics. Methods and results: We studied 39 candidates for BMV. Pressures were measured invasively before and after BMV. Speckle tracking echocardiography (STE) was done for twist mechanics (basal rotation, apical rotation, and torsion) before and immediately after BMV. Twist mechanics were also measured by STE in 15 normal subjects as control group. Mean age was 30.4 ± 7.2 years, mean BMI was 24.7 ± 3.1 and 28 patients (72%) were females. All twist mechanics apical rotation and torsion were lower post-BMV compared to pre-BMV. Left ventricular end diastolic pressure was significantly higher post compared to pre-BMV while left atrial pressure (LAP) was similar between both groups. Importantly, patients who showed an increased LVEDP post compared to pre-BMV had worse LV twist mechanics than those whose LVEDP post-BMV was similar to or lower than pre-BMV. Conclusion: LV twist mechanics are worsened in MS with a further worsening, immediately after BMV probably because of failure of the LV to adapt to the sudden increased preload.

Published
2016
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76. Inflammatory status in patients with rheumatic mitral stenosis: Guilty before and after balloon mitral valvuloplasty

Author

Mohamed Ahmed Abdel Rahman, Alaa Mabrouk Salem Omar, Mohammed Amin, and Osama Rifaie

Subjects
Rheumatic mitral stenosis, High sensitivity C-reactive protein, Balloon mitral valvuloplasty, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Aim: We studied the inflammatory status, suggested by high sensitivity C-reactive protein (hsCRP) in patients with rheumatic mitral stenosis (MS) before, immediately after, and 1-month after balloon mitral valvuloplasty (BMV). Methods and results: We studied 31 BMV candidates [35.6 ± 12.8 years, 20 (65%) females, and 9 (29%) had atrial fibrillation rhythm]. Mitral valve area (MVA) and hsCRP were measured before, immediately after BMV, and 1 month after BMV in 13 patients. In addition, hsCRP was measured in 15 controls. hsCRP was significantly higher in MS patients than control, significantly increased after BMV, and dropped 1 month after BMV to values comparable to basal but still higher than normal. hsCRP showed a trend for correlation with MVA after BMV (r = 0.384, p = 0.07), and the absolute increase in MVA (d-MVA) correlated significantly with the absolute increase in hsCRP (d-CRP) (r = 0.523, p = 0.01). 21 patients had successful BMV and 10 patients had unsuccessful BMV. The increase in hsCRP post compared to pre-BMV was attenuated in patients with unsuccessful BMV, and receiver operator characteristic curve suggested that hsCRP >3.6 before BMV and d-CRP

Published
2016
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78. Low Frequency Spinning LiDAR De-Skewing

Author

Salem, Omar, Giacomini, Emanuele, Brizi, Leonardo, Di Giammarino, Luca, and Grisetti, Giorgio

Subjects
FOS: Computer and information sciences, Computer Science - Robotics, Robotics (cs.RO)
Abstract

Most commercially available Light Detection and Ranging (LiDAR)s measure the distances along a 2D section of the environment by sequentially sampling the free range along directions centered at the sensor's origin. When the sensor moves during the acquisition, the measured ranges are affected by a phenomenon known as skewing, which appears as a distortion in the acquired scan. Skewing potentially affects all systems that rely on LiDAR data, however it could be compensated if the position of the sensor were known each time a single range is measured. Most methods to de-skew a LiDAR are based on external sensors such as IMU or wheel odometry, to estimate these intermediate LiDAR positions. In this paper we present a method that relies exclusively on range measurements to effectively estimate the robot velocities which are then used for de-skewing. Our approach is suitable for low frequency LiDAR where the skewing is more evident. It can be seamlessly integrated into existing pipelines, enhancing their performance at negligible computational cost. We validated the proposed method with statistical experiments characterizing different operating conditions, Comment: 6 pages , 5 figures

Published
2023
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79. Protective role of single versus multiple remote ischemic preconditioning in elective percutaneous coronary interventions

Author

Alaa Mabrouk Salem Omar and Mohamed Ahmed Abdel-Rahman

Subjects
Ischemic preconditioning, Myonecrosis, Elective percutaneous coronary intervention, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Aim: To compare single cycle remote ischemic preconditioning (single RIPC) to multiple cycles RIPC in attenuating cardiac myonecrosis and reducing MACE after elective PCI. Methods and results: 150 consecutive patients undergoing elective PCI were studied. Mean age was 54.5 ± 7.2 years and 42(28%) patients were females. 100 patients received RIPC (each cycle of RIPC was 5 min of inflation followed by 5 min of deflation), 50 by multiple cycles RIPC (group A), and 50 with single cycle RIPC (group B), while 50 patients did not receive RIPC (group C, control) before PCI. Myocardial ischemia during PCI, indicated by ST-segment deviation, was less in RIPC patients (31(31%) vs. 25(50%) patients, p = 0.023, 0.48 ± 0.81 mm vs. 0.96 ± 1.2 mm, p = 0.004; respectively), a difference that was similar when subgroups were compared to control (group A: 15, group B: 16, group C: 25 patients, p = 0.075, and group A: 0.46 ± 0.76, group B: 0.5 ± 0.86, group C:0.96 ± 1.2 mm, p = 0.015), with no difference between groups A and B. Myonecrosis, indicated by mean cTnI at 24 h after PCI, was lower in RIPC (0.043 ± 0.033, 0.06 ± 0.048 ng/ml, p = 0.01), higher in the control than subgroups (group A: 0.043 ± 0.034, group B: 0.042 ± 0.33, and group C: 0.06 ± 0.048 ng/ml, p = 0.002), again with no difference between groups A and B. At 3 months, there was a trend toward lower MACE, which was significant for acute coronary syndrome, in all the RIPC groups. Conclusion: Single-cycle RIPC can be an alternative to multiple-RIPC for protective effects after elective PCI, however single RIPC requires less time in the busy PCI setting.

Published
2015
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80. Correlation between serum vitamin D level and cardiac function: Echocardiographic assessment

Author

Mohammed Ahmed Abdel Rahman, Haitham Galal, and Alaa Mabrouk Salem Omar

Subjects
Vitamin D, Heart failure, Diastolic function, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background: The association between vitamin D and cardiovascular-diseases especially cardiac function is widely debated. Aim of work: To study the relation between serum 25-hydroxy vitamin D levels and parameters of cardiac systolic and diastolic functions in patients with LV systolic heart failure. Patients and methods: The study included 60 patients admitted to our hospital for management of symptomatic heart failure with systolic dysfunction (ejection fraction

Published
2015
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81. Proceedings of Réanimation 2017, the French Intensive Care Society International Congress

Author

Bougouin, Wulfran, Marijon, Eloi, Planquette, Benjamin, Karam, Nicole, Dumas, Florence, Celermajer, David, Jost, Daniel, Lamhaut, Lionel, Beganton, Frankie, Cariou, Alain, Meyer, Guy, Jouven, Xavier, Bureau, Côme, Charpentier, Julien, Salem, Omar Ben Hadj, Guillemet, Lucie, Arnaout, Michel, Ferre, Alexis, Geri, Guillaume, Mongardon, Nicolas, Pène, Frédéric, Chiche, Jean-Daniel, Mira, Jean-Paul, Labro, Guylaine, Belon, François, Luu, Vinh-Phuc, Chenet, Julien, Besch, Guillaume, Puyraveau, Marc, Piton, Gaël, Capellier, Gilles, Martin, Maëlle, Lascarrou, Jean-Baptiste, Le Thuaut, Aurélie, Lacherade, Jean-Claude, Martin-Lefèvre, Laurent, Fiancette, Maud, Vinatier, Isabelle, Lebert, Christine, Bachoumas, Konstantinos, Yehia, Aihem, Henry-Laguarrigue, Matthieu, Colin, Gwenhaël, Reignier, Jean, Privat, Elodie, Escutnaire, Joséphine, Dumont, Cyrielle, Baert, Valentine, Vilhelm, Christian, Hubert, Hervé, Robert-Edan, Vincent, Lakhal, Karim, Quartin, Andrew, Hobbs, Brian, Cely, Cynthia, Bell, Cynthia, Pham, Tai, Schein, Roland, Geng, Yimin, Ng, Chaan, Ehrmann, Stephan, Gandonnière, Charlotte Salmon, Boisramé-Helms, Julie, Le Tilly, Olivier, De Bretagne, Isabelle Benz, Mercier, Emmanuelle, Mankikian, Julie, Bretagnol, Anne, Meziani, Ferhat, Halimi, Jean Michel, Le Guellec, Chantal Barin, Gaudry, Stéphane, Hajage, David, Tubach, Florence, Pons, Bertrand, Boulet, Eric, Boyer, Alexandre, Chevrel, Guillaume, Lerolle, Nicolas, Carpentier, Dorothée, de Prost, Nicolas, Lautrette, Alexandre, Mayaux, Julien, Nseir, Saad, Ricard, Jean-Damien, Dreyfuss, Didier, Robert, René, Garzotto, Franscesco, Kipnis, Eric, Tetta, Ciro, Ronco, Claudio, Schnell, David, Aurelie, Bourmaud, Reynaud, Marie, Clec’h, Christophe, Benyamina, Mourad, Vincent, François, Mariat, Christophe, Bornstain, Caroline, Rouleau, Stephane, Leroy, Christophe, Cohen, Yves, Morel, Jerome, Legrand, Matthieu, Terreaux, Jeremy, Darmon, Michaël, Cantier, Marie, Morisot, Adeline, Guérot, Emmanuel, Canet, Emmanuel, De Montmollin, Etienne, Voiriot, Guillaume, Neuville, Mathilde, Timsit, Jean-François, Sonneville, Romain, Fayssoil, Abdallah, Stojkovic, Tania, Behin, Anthony, Ogna, Adam, Lofaso, Frédéric, Laforet, Pascal, Wahbi, Karim, Prigent, Helene, Duboc, Denis, Orlikowski, David, Eymard, Bruno, Annane, Djillali, Le Guennec, Loic, Cholet, Clémentine, Bréchot, Nicolas, Hekimian, Guillaume, Besset, Sébastien, Lebreton, Guillaume, Nieszkowska, Ania, Trouillet, Jean Louis, Leprince, Pascal, Combes, Alain, Luyt, Charles-Edouard, Griton, Marion, Sesay, Musa, De Panthou, Nadia Sibaï, Bienvenu, Thomas, Biais, Matthieu, Nouette-Gaulain, Karine, Fossat, Guillaume, Baudin, Florian, Coulanges, Cécile, Bobet, Sabrine, Dupont, Arnaud, Courtes, Léa, Benzekri, Dalila, Kamel, Toufik, Muller, Grégoire, Bercault, Nicolas, Barbier, François, Runge, Isabelle, Skarzynski, Marie, Mathonnet, Armelle, Boulain, Thierry, Jouan, Youenn, Teixera, Noémie, Hassen-Khodja, Claire, Guillon, Antoine, Gaborit, Christophe, Grammatico-Guillon, 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Aude, Taconet, Clementine, Djibre, Michel, Maamar, Adel, Colobert, Elen, Fillatre, Pierre, Uhel, Fabrice, Camus, Christophe, Moraly, Josquin, Dahoumane, Redouane, Maury, Eric, Tan, Boun Kim, Emmanuel, Vivier, Pauline, Misslin, Laurence, Parmeland, Philippe, Poirié, Zahar, Jean-Ralph, Catherine, Haond, Christian, Pommier, Karim, Ait-Bouziad, Mounia, Hocine, Laura, Témime, Rasoldier, Vero Hanitra, Mager, Guy, Eraldi, Jean-Pierre, Gelinotte, Stéphanie, Bougerol, François, Dehay, Julien, Rigaud, Jean-Philippe, Declercq, Pierre Louis, Michel, Julien, Aissa, Nejla, Henard, Sandrine, Guerci, Philippe, Latar, Ichraq, Levy, Bruno, Girerd, Nicolas, Kimmoun, Antoine, Abdallah, Saousen Ben, Nakaa, Sabrine, Hraiech, Kmar, Braiek, Dhouha Ben, Adhieb, Ali, M’ghirbi, Abdelwaheb, Ousji, Ali, Hammouda, Zeineb, Abroug, Fekri, Sellami, Walid, Hajjej, Zied, Samoud, Walid, Labbene, Iheb, Ferjani, Mustapha, Medhioub, Fatma Kaaniche, Allela, Rania, Algia, Najla Ben, Cherif, Samar, Attia, Delphine, 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Meddeb, Khaoula, Khedher, Ahmed, Sma, Nesrine, Ayachi, Jihene, Khelfa, Messaouda, Fraj, Nesrine, Lakhal, Hend Ben, Hammed, Hedia, Boukadida, Raja, Hafsa, Hajer, Chouchene, Imed, Boussarsar, Mohamed, Ben, Braiek Dhouha, Ouanes-Besbes, Lamia, Benatti, Kaoutar, Dafir, A., Aissaoui, W., Elallame, W., Haddad, W., Cherkab, R., Elkettani, C., Barrou, L., Hamou, Zakaria Ait, Repessé, Xavier, Charron, Cyril, Aubry, Alix, Paternot, Alexis, Maizel, Julien, Slama, Michel, Vieillard-Baron, Antoine, Trifi, Ahlem, Abdellatif, Sami, Fatnassi, Meriem, Daly, Foued, Nasri, Rochdi, Ismail, Khaoula Ben, Lakhal, Salah Ben, Bazalgette, Florian, Daurat, Aurelien, Roger, Claire, Muller, Laurent, Doyen, Denis, Plattier, Rémi, Robert, Alexandre, Hyvernat, Hervé, Bernardin, Gilles, Jozwiak, Mathieu, Gimenez, Julia, Mercado, Pablo, Depret, François, Tilouch, Najla, Mater, Houda, Habiba, Ben Sik Ali, Jaoued, Oussama, Gharbi, Rim, Hassen, Mohamed Fekih, Elatrous, Souheil, Pasquier, Pierre, Vuillemin, Quentin, Schaal, Jean-Vivien, Martinez, Thibault, Duron, Sandrine, Trousselard, Marion, Schwartzbrod, Pierre-Eric, Baugnon, Thomas, Dupic, Laurent, Gout, Caroline Duracher, De Saint Blanquat, Laure, Séguret, Sylvie, Le Ficher, Gaelle, Orliaguet, Gilles, Hubert, Philippe, Bigé, Naïke, Leblanc, Guillaume, Briand, Raphael, Brousse, Lucas, Brunet, Valentine, Chatelain, Léonard, Prat, Dominique, Jacobs, Frédéric, Demars, Nadège, Hamzaoui, Olfa, Moneger, Guy, Sztrymf, Benjamin, Duburcq-Gury, Emilie, Satre-Buisson, Léa, Duburcq, Thibault, Poissy, Julien, Robriquet, Laurent, Jourdain, Merce, Sécheresse, Thierry, Miquet, Mattéo, Simond, Alexis, Usseglio, Pascal, Hamdaoui, Yamina, Boussarsar, Mohamed, Desailly, Victoire, Brun, Patrick, Iglesias, Pauline, Huet, Jérémie, Masseran, Clémence, Claudon, Antoine, Ebeyer, Clément, Truong, Thomas, Tesnière, Antoine, Mignon, Alexandre, Gaudry, Stéphane, Resiere, Dabor, Valentino, Ruddy, Fabre, Julien, Roze, Benoit, Ferge, Jean-Louis, Charbatier, Cyrille, Marie, Sabia, Scholsser, Michel, Aitsatou, Signate, Raad, Mathieu, Cabie, Andre, Mehdaoui, Hossein, Cousin, Clement, Rousseau, Christophe, Llitjos, Jean-François, Alby-Laurent, Fanny, Toubiana, Julie, Belaidouni, Nadia, Cherruault, Marlène, Tamburini, Jérome, Bouscary, Didier, Fert, Sarah, Delile, Eugénie, Besnier, Emmanuel, Coquerel, David, Nevière, Rémi, Richard, Vincent, Tamion, Fabienne, Wei, Chaojie, Louis, Huguette, Margaux, Schmitt, Eliane, Albuisson, Sophie, Orlowski, Kimmoun, Antoine, Riad, Zakaria, Coroir, Marine, Rémy, Bernard, Camille, Bombled, Joffre, Jeremie, Aegerter, Philippe, Ilic, Dejan, Ginet, Marc, Pignard, Caroline, Nguyen, Philippe, Mourey, Guillaume, Samain, Emmanuel, Pili-Floury, Sebastien, Jouffroy, Romain, Nicolas, Caill, Alvarez, Jean-Claude, Tomasso, Maraffi, Philippe, Pascal, Raphalen, Jean-Herlé, Frédéric, J. 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K., Chlilek, A., Hajji, Ahmed, Louati, Assaad, Khaldi, Ammar, Borgi, Aida, Ghali, Nargess, Bouziri, Asma, Menif, Khaled, Ben, Jaballah Najla, Armel, Anwar, Brochon, Jeanne, Dumitrescu, Mihaela, Thévenot, Sarah, Saulnier, Jean-Pascal, Husseini, Khaled, Laland, Catherine, Cremniter, Julie, Bousseau, Anne, Castel, Olivier, Brémaud-Csizmadia, Cassandra, Diss, Margot, Portefaix, Aurélie, Berthiller, Julien, Gillet, Yves, Aoul, Nabil Tabet, Douah, Ali, Addou, Zakaria, Youbi, Houari, Moussati, Mohamed, Belhabiche, Kamel, Mir, Souad, Abada, Sanaa, Amel, Zerhouni, Aouffen, Nabil, Bouzit, Zina, Grati, Ahmed H., Dhonneur, Gilles F., Boussarsar, Mohamed, Lau, Nicolas, Mezhari, Ilham, Roucaud, Nicolas, Le Meur, Matthieu, Paulet, Rémi, Coudray, Jean-Michel, Ghomari, Wahiba Imène, Boumlik, Reda, Peigne, Vincent, Daban, Jean-Louis, Boutonnet, Mathieu, Lenoir, Bernard, Yassine, Hafiani, Mohamed, Cheikh Chaigar, Khalid, Allali, Ihssan, Moussaid, Said, Elyoussoufi, Said, Salmi, Jazia, Amira Ben, Fatima, 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Essafi, Fatma, Benabderrahim, A., Jouffroy, Romain, Resiere, Dabor, Sanchez, Bruno, Inamo, Jocelyn, Megarbane, Bruno, Batouche, Djamila-Djahida, Zerhouni, Amel, Tabeliouna, Kheira, Negadi, Amine, Mentouri, Zahia, Le Gall, Fanny, Hanouz, Jean-Luc, Normand, Hervé, Khoury, Abdo, Sall, Fatimata Seydou, De Luca, Alban, Pugin, Aurore, Pazart, Lionel, Vidal, Chrystelle, Leroux, Franck, Khoury, Abdo, L’Her, Erwan, Marjanovic, Nicolas, Khoury, Abdo, Desmettre, Thibault, Lambert, Christophe, Ragey, Sophie Perinel, Baboi, Loredana, Bazin, Jean-Etienne, Koffel, Catherine, Dhonneur, Gilles, Bouzit, Zina, Bradai, Larbi, Ayed, Issam Ben, Aissa, Fethi, Haouache, Hakim, Marechal, Yoann, Biston, Patrick, Piagnerelli, Michael, Bortolotti, Perrine, Colling, Delphine, Colas, Vincent, Voisin, Benoit, Dewavrin, Florent, Onimus, Thierry, Girardie, Patrick, Saulnier, Fabienne, Urbina, Tomas, Nguyen, Yann, Druoton, Anne-Lise, Soudant, Marc, Barraud, Damien, Conrad, Marie, Cravoisy-Popovic, Aurélie, Nace, 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Andrejak, Claire, Ricome, Sylvie, Dupont, Hervé, Baudin, François, Dureau, Pauline, Tanguy, Audrey, Arbelot, Charlotte, Ben, Hassen Kais, Charfeddine, Ahmed, Granger, Benjamin, Laporte, Lucile, Hermetet, Coralie, Regaieg, Kais, Khemakhem, Rim, Chelly, Hedi, Cheikh, Chaigar Mohammed, Mountij, Hamid, Rghioui, Kawtar, Haddad, Wafae, Cherkab, Rachid, Barrou, Houcine, Naima, Aitmouden, bennani, Othmani M., Regaieg, Kais, Douib, Ahmed, Samet, Amal, Cungi, Pierre-Julien, Nguyen, Cédric, Cotte, Jean, D’aranda, Erwan, Meaudre, Eric, Avaro, Jean-Phillipe, Slaoui, Mohamed Taoufik, Mokline, Amel, Rahmani, Imene, Laajili, Achraf, Amri, Helmi, Gharsallah, Lazheri, Gasri, Bahija, Tlaili, Sofiene, Hammouda, Rym, Messadi, Amen Allah, Sudden Death Expertise Center, AKIKI Study Group, DO-RE-MI-FA Group, ENCEPHALITICA Study Group, for the HYPER2S Investigators and REVA Research Network, for the Purpura Fulminans Study Group, GFRUP RMEF, REVA ECMOnet, REA-RAISIN Study Group, for the EurêClark Study Group, and Groupe Communication et Simulation en Pédiatrie

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2017
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83. Chronic hepatitis-C infection in COVID-19 patients is associated with in-hospital mortality

Author

YongsuN Choi, Harish Patel, Haozhe Sun, Sridhar Chilimuri, Dongmin Shin, Alaa Mabrouk Salem Omar, Hafsa Abbas, Ahmed Baiomi, Nikhitha Mantri, Jasbir Makker, Ked Fortuzi, and Diana Ronderos

Subjects
Acute liver injury, 2019-20 coronavirus outbreak, medicine.medical_specialty, In hospital mortality, Coronavirus disease 2019 (COVID-19), business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), virus diseases, Observational Study, COVID-19, Seropositive, General Medicine, Hepatitis C, medicine.disease, Chronic hepatitis, Internal medicine, medicine, Mortality, business
Abstract

BACKGROUND There is little evidence about the association of pre-existing hepatitis C infection (HCV) with outcomes in patients with coronavirus disease 2019 (COVID-19). AIM To assess the prevalence of history of HCV among patients with COVID-19 and to study the relationship of in-hospital mortality in relation with other predictors of poor outcomes in the presence or absence of COVID-19 induced acute liver injury. METHODS In a retrospective single-center study design, 1193 patients with COVID-19 infection were studied. Patients were then classified into those with and without a history of HCV, 50 (4.1%) and 1157 (95.9%) respectively. RESULTS Multivariate cox-regression models showed that age, HCV, D-Dimer, and ferritin were the only predictors of in-hospital mortality. Acute liver injury and fibrosis score (Fib-4 score) were not different between both groups. Multivariate cox-regression model for liver profile revealed that aspartate aminotransferase/ alanine aminotransferase ratio, Fib-4 score, and HCV were predictors of in-hospital mortality. After propensity score matching HCV was the only predictor of mortality in the multivariate cox-regression model. A model including HCV was found to add predictive value to clinical and laboratory parameters. CONCLUSION In patients with COVID-19, history of HCV infection leads to an accentuated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virulence, irrespective of baseline comorbidities, admission laboratory variables, or COVID-19-induced liver injury, which may be related to extrahepatic effects of HCV leading to enhanced ACE-2/TMPRSS mechanisms of SARS-CoV-2 viral entry, baseline cytokine-mediated pro-inflammation, and endothelial dysfunction.

Published
2021

84. Radius of proximal isovelocity surface area in the assessment of rheumatic mitral stenosis: Connecting flow to anatomy and hemodynamics

Author

Alaa Mabrouk Salem Omar, Mohamed Ahmed Abdel-Rahman, Hala Raslan, and Osama Rifaie

Subjects
Mitral stenosis, Mitral valve area, Left atrial pressure, Proximal isovelocity surface area, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background: Echocardiographic assessment of left atrial pressure (LAP) in mitral stenosis (MS) is controversial. We sought to examine the role of the radius of the proximal isovelocity surface area (PISA-r) in the assessment of the hemodynamic status of MS after fixing the aliasing velocity (Val). Methods and results: We studied 42 candidates of balloon mitral valvuloplasty (BMV), for whom pre-BMV echocardiography was done and LAP invasively measured before dilatation. PISA-r was calculated after fixing aliasing velocity to 33 cm/s. In addition, the ratio IVRT/Te’–E was also measured, where IVRT was isovolumic relaxation time, and Te’–E was the time difference between the onset of mitral flow E-wave and mitral annular early diastolic velocity. IVRT/Te’–E and PISA-r showed a strong correlation with LAP (r = −0.715 and −0.637, all p

Published
2015
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98. Ischemic injury of the upper gastrointestinal tract after out-of-hospital cardiac arrest: a prospective, multicenter study

Author

Grimaldi, David, Legriel, Stéphane, Pichon, Nicolas, Colardelle, Philippe, Leblanc, Sina, Canouï-Poitrine, Florence, Salem, Omar O.B.H., Muller, Grégoire, de Prost, Nicolas, Herrmann, S., Marque, Sophie, Baron, Audrey, Sauneuf, Bertrand, Messika, Jonathan, Dior, Marie, Creteur, Jacques, Bedos, Jean Pierre, Boutin, Emmanuelle, Cariou, Alain, Grimaldi, David, Legriel, Stéphane, Pichon, Nicolas, Colardelle, Philippe, Leblanc, Sina, Canouï-Poitrine, Florence, Salem, Omar O.B.H., Muller, Grégoire, de Prost, Nicolas, Herrmann, S., Marque, Sophie, Baron, Audrey, Sauneuf, Bertrand, Messika, Jonathan, Dior, Marie, Creteur, Jacques, Bedos, Jean Pierre, Boutin, Emmanuelle, and Cariou, Alain

Abstract

Background: The consequences of cardiac arrest (CA) on the gastro-intestinal tract are poorly understood. We measured the incidence of ischemic injury in the upper gastro-intestinal tract after Out-of-hospital CA (OHCA) and determined the risk factors for and consequences of gastrointestinal ischemic injury according to its severity. Methods: Prospective, non-controlled, multicenter study in nine ICUs in France and Belgium conducted from November 1, 2014 to November 30, 2018. Included patients underwent an esophago-gastro-duodenoscopy 2 to 4 d after OHCA if still intubated and the presence of ischemic lesions of the upper gastro-intestinal tract was determined by a gastroenterologist. Lesions were a priori defined as severe if there was ulceration or necrosis and moderate if there was mucosal edema or erythema. We compared clinical and cardiac arrest characteristics of three groups of patients (no, moderate, and severe lesions) and identified variables associated with gastrointestinal ischemic injury using multivariate regression analysis. We also compared the outcomes (organ failure during ICU stay and neurological status at hospital discharge) of the three groups of patients. Results: Among the 214 patients included in the analysis, 121 (57%, 95% CI 50–63%) had an upper gastrointestinal ischemic lesion, most frequently on the fundus. Ischemic lesions were severe in 55/121 (45%) patients. In multivariate regression, higher adrenaline dose during cardiopulmonary resuscitation (OR 1.25 per mg (1.08–1.46)) was independently associated with increased odds of severe upper gastrointestinal ischemic lesions; previous proton pump inhibitor use (OR 0.40 (0.14–1.00)) and serum bicarbonate on day 1 (OR 0.89 (0.81–0.97)) were associated with lower odds of ischemic lesions. Patients with severe lesions had a higher SOFA score during the ICU stay and worse neurological outcome at hospital discharge. Conclusions: More than half of the patients successfully resuscitated from OHCA, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2022

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