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58. Antiulcerogenic activity of Teucrium divaricatum Heldr. ssp. divaricatum

Author

Galati, EM Sanogo, R Tzakou, O Rossitto, A Germano, MP

Abstract

The methanol extract and lyophilized decoction of Teucrium divaricatum Heldr ssp, divaricatum protected gastric mucosa against lesions induced by ethanol in rats. The preventive antiulcer effect of preparations was reversed by pretreatment with indomethacin. Nevertheless, in the Shay-ligated method no decrease in either total volume, acidity or peptic activity of gastric juice was observed. (C) 1997 John Wiley & Sons, Ltd.

Published
1997

60. Antiulcerogenic activity of Teucrium divaricatum Heldr. ssp. divaricatum

Author

Galati, E.M. Sanogo, R. Tzakou, O. Rossitto, A. Germanó, M.P.

Subjects
digestive system diseases
Abstract

The methanol extract and lyophilized decoction of Teucrium divariactum Heldr ssp. divaricatum protected gastric mucosa against lesions induced by ethanol in rats. The preventive antiulcer effect of preparations was reversed by pretreatment with indomethacin. Nevertheless, in the Shay-ligated method no decrease in either total volume, acidity or peptic activity of gastric juice was observed.

Published
1997

71. New pregnane glycosides from

Author

DELEO, M, primary, DETOMMASI, N, additional, SANOGO, R, additional, AUTORE, G, additional, MARZOCCO, S, additional, PIZZA, C, additional, MORELLI, I, additional, and BRACA, A, additional

Published
2005
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94. HPLC-UV/PAD and HPLC-MS n analyses of leaf and root extracts of Vismia guineensis and isolation and identification of two new bianthrones.

Author

Politi, M., Sanogo, R., Ndjoko, K., Guilet, D., Wolfender, J.-L., Hostettmann, K., and Morelli, I.

Abstract

In order to evaluate the possible use of the leaves instead of the roots of Vismia guineensis as a new source for the traditional use of this drug, the chemical composition of both organs were compared by HPLC-UV/PAD and HPLC-MS analyses. The leaves are analysed here for the first time. The results show the presence of five major classes of secondary metabolites having specific chromophores: anthraquinones, vismiones, flavonoids, xanthones and benzophenones. The molecular weights and characteristic fragments, compared with previous EI or HPLC-MS literature data, allowed the partial identification of the major peaks in the chromatograms. Six additional isomeric bianthrones and one anthraquinone were detected in the dichloromethane extract of the roots after long storage in solution; the targeted isolation of the bianthrones was performed and enabled the identification of two original C-geranyl derivatives. The chemical compositions of the extracts demonstrated that only a minority of the constituents is shared by both organs. Thus, in order to establish a definitive phytoequivalence, additional pharmacological investigations are required. Copyright © 2004 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2004
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96. Anti-inflammatory Activity of Verminoside from Kigelia africana and Evaluation of Cutaneous Irritation in Cell Cultures and Reconstituted Human Epidermis

Author

Picerno, P., Autore, G., Marzocco, S., Meloni, M., Sanogo, R., and Aquino, R. P.

Abstract

Kigelia africana is a plant used in Africa for anti-inflammatory, anti-microbial, and anti-skin-aging effects. Various papers have reported on the composition and biological activities of its CH2Cl2 extracts and dermal formulations. Chemical analysis of a polar extract of fruit from K. africana indicated the presence of verminoside (1), an iridoid, as a major constituent, and of a series of polyphenols such as verbascoside (2). In vitro assays showed that 1 had significant anti-inflammatory effects, inhibiting both iNOS expression and NO release in the LPS-induced J774.A1 macrophage cell line. Cytotoxicity and cutaneous irritation of the extract and of compounds 1 and 2 were investigated. The crude extract and 1 did not affect cell viability in vitro either in cells grown in monolayers (ML) or in the reconstituted human epidermis (RHE, 3D) model; neither caused release of pro-inflammatory mediators or histomorphological modification of RHE.

Published
2005

97. Hepatoprotective activity of Trichilia rokaon carbon tetrachloride‐induced liver damage in rats

Author

Germanò, M. P., D'Angelo, V., Sanogo, R., Morabito, A., Pergolizzi, S., and Pasquale, R.

Abstract

Trichilia rokaChiov. (Meliaceae) is a tree widely distributed in tropical Africa. It has been used in Mali folk medicine for the treatment of various illnesses. A decoction of the roots is taken as a remedy for colds and pneumonia, and it is used as a diuretic and in hepatic disorders. We have evaluated the hepatoprotective effects of a decoction of Trichilia rokaroot on CCl4‐induced acute liver damage in rats. Treatment with the decoction showed a significant protective action made evident by its effect on the levels of glutamate oxalacetate transaminase and glutamate pyruvate transaminase in the serum, on the protein content and lipid peroxidation levels in the liver homogenate. Histopathological changes produced by CCl4, such as necrosis, fatty change, ballooning degeneration and inflammatory infiltration of lymphocytes around the central veins, were clearly recovered by the treatment with Trichiliaroot decoction. On fractionating this extract into diethyl ether‐soluble and water‐soluble fractions, the activity was retained in the diethyl ether‐soluble fraction. Moreover, the administration of decoction prevented a preferential deposition of collagen around the sinusoidal cell layer, which is responsible for the perisinusoidal fibrosis in the early stage of CCl4damage. This study showed that treatment with Trichilia rokaextracts or silymarin (as reference) appeared to enhance the recovery from CCl4‐induced hepatotoxicity. The hepatoprotective properties of Trichilia rokamay be correlated to polyphenol content of the decoction and its diethyl ether‐soluble fraction.

Published
2001
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100. Essential oil composition of Nepeta argolicaBory et Chaub. subsp. argolica

Author

Tzakou, O, Harvala, C, Galati, E. M, and Sanogo, R

Abstract

The chemical composition of the essential oils obtained from the herbal parts and different plant parts of Nepeta argolicaBory et Chaub. subsp. argolicawas examined by GC and GC–MS. Sixty‐two con‐ystituents were identified. The major constituents were found to be stereoisomers of nepetalactones (94.5–68.0%). 4aα,7α,7aβ‐nepetalactone was isolated and identified by 1H‐ and 13C‐NMR. Copyright © 2000 John Wiley & Sons, Ltd.

Published
2000
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