161 results on '"Satou, H."'
Search Results
52. A 1.2v 3.5mW ΔΣ modulator with a passive current summing network and a variable gain function
- Author
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Nagai, T., primary, Satou, H., additional, Yamazaki, H., additional, and Watanabe, Y., additional
- Full Text
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53. A simulation system for evaluating customer service operations in telephone companies
- Author
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Immanaka, H., primary, Satou, H., additional, and Ikeuchio, N., additional
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54. Computer aided diagnosis system with functions to assist comparative reading for lung cancer based on helical CT image
- Author
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Yamamoto, T., primary, Ukai, Y., additional, Kubo, M., additional, Niki, N., additional, Satou, H., additional, and Eguchi, K., additional
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55. New polyimide for multi-chip module application
- Author
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Satou, H., primary, Kojima, M., additional, Makino, D., additional, Kikuchi, T., additional, and Saito, T., additional
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56. Mono-grooved circular waveguide polarizers
- Author
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Yoneda, N., primary, Miyazaki, M., additional, Horie, T., additional, and Satou, H., additional
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57. VISUALIZATION AND QUANTITATIVE EVALUATION OF APERTURE DISTRIBUTION, FLUID FLOW AND TRACER TRANSPORT IN A VARIABLE APERTURE FRACTURE.
- Author
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XIAO, J., SATOU, H., SAWADA, A., and TAKEBE, A.
- Subjects
FLUID dynamics ,PARTICLE image velocimetry ,ROCK mechanics - Published
- 2006
58. A 1.2V 3.5mW ΔΣ modulator with a passive current summing network and a variable gain function.
- Author
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Nagai, T., Satou, H., Yamazaki, H., and Watanabe, Y.
- Published
- 2005
- Full Text
- View/download PDF
59. IGAP: secure group management protocol for multicast content delivering network.
- Author
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Hayashi, T., Tanabe, A., Andou, D., Izutsu, K., Satou, H., He, H., and Tawbi, W.
- Published
- 2004
- Full Text
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60. Computer aided diagnosis system with functions to assist comparative reading for lung cancer based on helical CT image.
- Author
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Yamamoto, T., Ukai, Y., Kubo, M., Niki, N., Satou, H., and Eguchi, K.
- Published
- 2000
- Full Text
- View/download PDF
61. New polyimide for multi-chip module application.
- Author
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Satou, H., Kojima, M., Makino, D., Kikuchi, T., and Saito, T.
- Published
- 1990
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62. New screen-printable polyimide for IC devices.
- Author
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Nishizawa, H., Suzuki, K., Kikuchi, T., and Satou, H.
- Published
- 1990
- Full Text
- View/download PDF
63. A case of repeated Kounis syndrome after anaphylactic shock: A note for disease management.
- Author
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Kawaguchi S, Kuroshima T, Namba R, Satou H, Kashiwagi R, Abe A, and Okada M
- Abstract
Background: Kounis syndrome (KS) is an underdiagnosed disease. The management of the disease remains elusive because of its infrequency., Case Presentation: A 78-year-old man with anaphylactic shock was admitted to our hospital 2 h after multiple bee stings. After recovering from an anaphylactic reaction, he presented with chest pain with ST elevation. We diagnosed him with KS. After a continuous intravenous infusion of vasodilators, his chest pain and ST elevation improved. However, chest pain with ST-segment elevation recurred the next day. Coronary angiography revealed severe stenosis in the middle left anterior descending coronary artery, and drug-eluting stents were implanted. The patient was discharged on foot after treatment for heart failure., Conclusion: KS, in which anaphylaxis and acute coronary syndrome occur simultaneously, can recur repeatedly after an initial anaphylactic reaction; however, it could be delayed or it could present simultaneously with the anaphylactic reaction. Therefore, long-term observation is important., Competing Interests: None declared., (© 2024 The Authors. Acute Medicine & Surgery published by John Wiley & Sons Australia, Ltd on behalf of Japanese Association for Acute Medicine.)
- Published
- 2024
- Full Text
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64. Clinical Study of a High Accuracy Green Design Blood Glucose Monitor Using an Innovative Optical Transmission Absorbance System.
- Author
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Moriuchi T, Otaki Y, Satou H, Chai F, Hayashida Y, Aikawa R, Sugiyama T, and Sode K
- Subjects
- Blood Glucose, Blood Glucose Self-Monitoring, Data Collection, Humans, Diabetes Mellitus, Type 2, Hyperglycemia
- Abstract
Background: Blood glucose monitoring (BGM) is essential for glycemic control in diabetic therapy. Followingly, accurate sensors are required for both daily personal and clinical use. The frequency of sensor use in patients with diabetes facilitates the use of disposable components. However, BGM systems are not exempt from green innovation sustainability initiatives., Methods: Clinical study of a high-accuracy green design blood glucose monitor using an innovative optical transmission absorbance system was carried out. Venous blood samples were collected from 104 patients with type II diabetes. The heat resistance of sensor strips was evaluated by storing sensor strips at 25℃ and 60℃ for approximately 3 months. Accuracy of the BGM system was evaluated via the ISO 15197:2013 protocol., Results: The BGM system achieved ±7.1% accuracy in glycemic level measurement, with 84% of all measurements within ±5% of the reference values. Furthermore, the sensor strip demonstrated heat resistance for more than 3 months when stored at 60℃., Conclusions: A new, highly accurate BGM system was developed based on the latest optical measurement system, introducing a rare metal-free "green-strip." The developed BGM system achieved the highest reported accuracy in clinical research, using venous blood from patients with diabetes. The sensor strip also exhibited high heat resistance, reducing limitations on storage conditions.
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- 2022
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65. [Formulation of Industry Infection Prevention Guidelines for Safe and Secure Visits to Medical Institutions].
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Satou H
- Subjects
- Humans, Cross Infection prevention & control
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- 2021
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66. [A Forensic Autopsy Case in which Sulpiride and Estazolam Were Detected in an Adipoceratous Cadaver by LC-MS/MS].
- Author
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Kasai K, Tanaka T, and Satou H
- Subjects
- Anti-Anxiety Agents isolation & purification, Antipsychotic Agents isolation & purification, Estazolam isolation & purification, Humans, Male, Muscle, Skeletal chemistry, Sulpiride isolation & purification, Time Factors, Anti-Anxiety Agents analysis, Antipsychotic Agents analysis, Autopsy, Cadaver, Chromatography, Liquid methods, Estazolam analysis, Forensic Medicine methods, Postmortem Changes, Sulpiride analysis, Tandem Mass Spectrometry methods
- Abstract
We had a forensic autopsy case in which drugs were detected in a cadaver that had been stored in a cold and wet condition for 5 years. The skin of the cadaver was hard, and the color was partly whitish or dark brown. Though the cadaver had transformed into adipocere in the wet and cold condition, QuEChERS extraction and LC-MS/MS revealed the presence of sulpiride and estazolam in the femoral muscle and bone marrow. The concentrations of sulpiride and estazolam in the femoral muscle were 10.6 ng/g and 39.9 ng/g, respectively. The result of a drug screening test led not only to the cause of death but also to the personal identification of the cadaver. The individual had a history of drug taking, which had been stored in his medical records at the hospital for a long time. The fact of taking sulpiride and estazolam at the same time was characteristic, and it was useful in identifying the cadaver in this case. The progress in analytical technology has made possible the detection of particle drugs from old or adipoceratous cadavers, but there have been no reports of particle drugs being detected in a cadaver that had been dead for 5 years and had transformed to adipocere, as in our present case. The analytical results by LC-MS/MS were certainly important for the diagnosis of the cause of death, and, moreover, they were useful for the purpose of personal identification.
- Published
- 2019
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67. Long-term outcome of congenital nephrotic syndrome after kidney transplantation in Japan.
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Hamasaki Y, Muramatsu M, Hamada R, Ishikura K, Hataya H, Satou H, Honda M, Nakanishi K, and Shishido S
- Subjects
- Child, Child, Preschool, Female, Humans, Infant, Japan epidemiology, Kidney Transplantation, Male, Nephrotic Syndrome surgery, Retrospective Studies, Nephrotic Syndrome epidemiology
- Abstract
Background: Congenital nephrotic syndrome is difficult to manage, particularly the Finnish type (CNF), with patients experiencing severe edema, sepsis and thrombosis before kidney transplantation. Further, nephrosis and thrombosis remain problematic after transplantation., Methods: Of 22 CNF patients managed at our hospital, 14 who underwent kidney transplantation were retrospectively studied. CNF was diagnosed according to standard criteria., Results: The study population consisted of 3 males and 11 females. Mean gestation period was 36 ± 1.4 weeks and mean birth weight was 2442 ± 454 g (mean placenta to body weight ratio: 0.4). All patients started dialysis at 2.4 ± 1.3 years and underwent kidney transplantation at 5.2 ± 2.0 years. The kidneys were donated by the parents (n = 13), and cadaver (n = 2), including overlap. Mean follow-up period after transplantation was 14.3 ± 8.9 years, and mean age at last observation was 19.5 ± 8.5 years. Two patients had recurrent proteinuria after kidney transplantation; one underwent retransplantation following graft failure and eventually required dialysis, while the second had complete remission after intensive immunosuppressive therapy. There were no cases of thrombosis or serious infections. Mean eGFR at the time of last observation was 57.3 ± 16.5 ml/min/1.73 m
2 , while mean height SD score was - 2.1 ± 0.9 at the time of transplantation and - 1.5 ± 1.5 at last observation., Conclusions: Long-term outcome in these 14 CNF patients showed satisfactory graft survival, improved height SD score, and favorable development. Although recurrent proteinuria after transplant was not predictive, it was associated with graft survival rate.- Published
- 2018
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68. Safety of Live Case Demonstrations in Patients Undergoing Percutaneous Coronary Intervention for Chronic Total Occlusion.
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Shimura T, Yamamoto M, Tsuchikane E, Teramoto T, Kimura M, Satou H, Matsuo H, Kawase Y, Suzuki Y, Kano S, Habara M, Nasu K, Kinoshita Y, Terashima M, Matsubara T, and Suzuki T
- Subjects
- Aged, Aged, 80 and over, Case-Control Studies, Chronic Disease, Databases, Factual, Female, Fluoroscopy, Humans, Japan epidemiology, Male, Middle Aged, Operative Time, Percutaneous Coronary Intervention methods, Retrospective Studies, Treatment Outcome, Aortic Dissection epidemiology, Congresses as Topic, Coronary Occlusion surgery, Intraoperative Complications epidemiology, Patient Safety, Percutaneous Coronary Intervention education, Registries, Telecommunications
- Abstract
The data regarding the risk and benefits associated with live demonstrations at interventional cardiology congresses are scarce and controversial. We aimed to assess the clinical safety of chronic total occlusion percutaneous coronary intervention (CTO-PCI) procedures during live demonstrations. From January 2008 to December 2013, 739 consecutive patients underwent CTO-PCI at our center, and 199 patients were scheduled to undergo live CTO-PCI demonstrations at cardiology congresses that were globally transmitted to international meetings. The baseline characteristics, procedural complications, and clinical outcomes were compared between the live demonstration group and nonlive demonstration group. The procedural success rates were similar in the live demonstration group than in the nonlive demonstration group (91.5% vs 86.7%, p = 0.076), although the CTO lesions were longer and more tortuous in the live demonstration group (p = 0.029, p = 0.022, respectively). No cases of 30-day mortality were noted in the live demonstration group (0% vs 0.7%, p = 0.28), and no significant differences in procedural complications, such as coronary dissection, coronary perforation, and cardiac tamponade, were observed between the groups (p = 0.53, p = 0.12, and p = 0.40, respectively). The survival rates were similar in the 2 groups at a median follow-up duration of 51.2 ± 28.9 months (log-rank test: p = 0.45). Compared with cases of unsuccessful CTO-PCI, the cases of successful CTO-PCI exhibited improved all-cause survival in both the live and nonlive demonstration groups (log-rank test: p = 0.045, p = 0.0056, respectively). In conclusion, we found that procedural and clinical outcomes of live demonstration CTO-PCI were not significantly different compared with cases undergoing routine CTO-PCI procedures., (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Published
- 2016
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69. The use of rat spinal reflexes to quantify injection pain.
- Author
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Ami N and Satou H
- Subjects
- Adalimumab administration & dosage, Animals, Antirheumatic Agents administration & dosage, Electrodes, Implanted, Electromyography, Etanercept administration & dosage, Foot, Humans, Hydrogen-Ion Concentration, Injections, Subcutaneous, Male, Osmotic Pressure, Pain Measurement, Rats, Sprague-Dawley, Reflex drug effects, Subcutaneous Tissue innervation, Thigh, Adalimumab adverse effects, Antirheumatic Agents adverse effects, Disease Models, Animal, Etanercept adverse effects, Pain chemically induced, Spinal Nerves drug effects, Subcutaneous Tissue drug effects
- Abstract
Pain caused by subcutaneous injections is unpleasant, which may limit patient compliance. The objective of this study was to use spinal reflexes to quantify subcutaneous injection pain. Spinal reflexes were measured using an electromyogram (EMG) test. The effects of injection volume, pH and osmotic pressure were investigated. The EMG responses increased with injection volume and the acidity of the solution but did not depend on the osmotic pressure of the solution. The EMG responses differed for subcutaneously injected sodium chloride and glucose over the same range of osmotic pressures. Pain caused by the subcutaneous injections was unrelated to the osmotic ratio up to approximately 5. The injection pain caused by therapeutic protein solutions was also evaluated. We compared the EMG responses of the adalimumab and etanercept, as the injection of adalimumab is more painful than that of etanercept in humans. The EMG magnitude for adalimumab was twice that induced by etanercept as observed for the EMG tests performed in rats. Therapeutic proteins account for an increasingly large proportion of pharmaceutical drugs. When a high dose of therapeutic proteins is required, the protein solution must often be highly concentrated to reduce the injection volume. For patient comfort, it is critical to reduce injection pain. The EMG test reported here allows subcutaneous injection pain to be quantified and may be useful for optimizing drug formulations., (Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.)
- Published
- 2015
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70. A case of radiation-induced subclavian artery stenosis treated with percutaneous transluminal angioplasty.
- Author
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Yamanaka T, Fukatsu T, Satou H, Ichinohe Y, Komatsu H, and Hirata Y
- Abstract
We report on a female patient who underwent a standard radical mastectomy and radiation therapy for right breast cancer at the age of 50 years without recurrence. At the age of 76 years, she started to experience fatigue in the right upper limb. The symptom gradually worsened and she was admitted to our hospital for further investigation. With computed tomography scan and angiography, we observed a high degree of subclavian artery (SCA) stenosis and asymptomatic right common carotid artery (CCA) stenosis. After undergoing carotid artery stenting to the right CCA stenosis at another hospital, we performed percutaneous transluminal angioplasty to SCA. Although we chose to treat the highly calcified lesion only with a balloon and slightly decreased the degree of stenosis, her symptoms clearly improved. Since arterial severely stenotic lesions were limited in the area of radiation exposure while other part of the arteries looked smooth and relatively free of sclerosis, it was highly suspected that arterial injury was induced by radiation. There are few reports of radiation-induced injury of upper limbs. However, this case suggests that we need to consider the possibility of radiation-induced arterial injury in patients with a history of radiation therapy. < Learning objective: There are few reports regarding upper limb arterial stenosis and occlusion due to radiation-induced arterial injury. However, the underlying mechanism might be overlooked because the symptoms such as fatigue and numbness of the upper limb caused by arterial stenosis and occlusion resembled those of lymphedema and nerve disorders that frequently occur after mastectomy. This case suggests that we need to consider the possibility of radiation-induced arterial injury in the patients with a history of radiation therapy.>.
- Published
- 2015
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71. Whole-body counter surveys of Miharu-town school children for four consecutive years after the Fukushima NPP accident.
- Author
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Hayano RS, Tsubokura M, Miyazaki M, Satou H, Sato K, Masaki S, and Sakuma Y
- Subjects
- Adolescent, Body Burden, Cesium Radioisotopes analysis, Child, Drinking, Female, Humans, Japan, Male, Data Collection, Fukushima Nuclear Accident, Schools, Whole-Body Counting
- Abstract
Comprehensive whole-body counter surveys of Miharu-town school children have been conducted for four consecutive years, in 2011-2014. This represents the only long-term sampling-bias-free study of its type conducted after the Fukushima Dai-ichi accident. For the first time in 2014, a new device called the Babyscan, which has a low (134/137)Cs MDA of <50 Bq/body, was used to screen the children shorter than 130 cm. No child in this group was found to have detectable level of radiocesium. Using the MDAs, upper limits of daily intake of radiocesium were estimated for each child. For those screened with the Babyscan, the upper intake limits were found to be ≲1 Bq/day for (137)Cs. Analysis of a questionnaire filled out by the children's parents regarding their food and water consumption shows that the majority of Miharu children regularly consume local and/or home-grown rice and vegetables. This however does not increase the body burden.
- Published
- 2015
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72. Assessment of 8-methosypsoralen, lomefloxacin, sparfloxacin, and Pirfenidone phototoxicity in Long-Evans rats.
- Author
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Adachi T, Satou Y, Satou H, Shibata H, Miwa S, Iwase Y, Yamamoto T, Nishida A, and Masutomi N
- Subjects
- Animals, Blood Proteins metabolism, Cornea drug effects, Cornea metabolism, Dermatitis, Phototoxic metabolism, Dermatitis, Phototoxic pathology, Eye drug effects, Eye metabolism, Eye pathology, Eye radiation effects, Female, Fluoroquinolones blood, Fluoroquinolones pharmacokinetics, Furocoumarins blood, Furocoumarins pharmacokinetics, Mice, No-Observed-Adverse-Effect Level, Pyridones blood, Pyridones pharmacokinetics, Rats, Long-Evans, Skin drug effects, Skin metabolism, Skin pathology, Skin radiation effects, Dermatitis, Phototoxic etiology, Fluoroquinolones toxicity, Furocoumarins toxicity, Pyridones toxicity, Ultraviolet Rays
- Abstract
Phototoxicity has a strong impact on drug development. Although several animal models have been developed to quantitatively assess human risks, none have been validated for standardized use. In this study, we validated an in vivo phototoxicity model using Long-Evans (LE) rats treated with 4 well-known phototoxic drugs, namely 8-methoxypsoralen, lomefloxacin, sparfloxacin, and pirfenidone. Daily macroscopic observations of skin and eyes, ophthalmological examinations 4 days after dosing, and blood sampling for toxicokinetics (TKs) were performed after exposure of treated animals to ultraviolet, and dose-dependent eye and/or skin reactions were noted for all compounds. Margins of safety were calculated when possible and correlated well with known relative phototoxicity of the 4 compounds. We conclude that the present in vivo phototoxicity assay using LE rats with TK analysis can be used to quantitatively predict the risk of pharmaceutical phototoxicity in humans., (© The Author(s) 2014.)
- Published
- 2015
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73. [Let's interpret laboratory data as physical findings].
- Author
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Sugano M, Shimada M, Satou H, Ooba K, Kitagawa F, and Honda T
- Subjects
- Evidence-Based Medicine, Humans, Time Factors, Medical Laboratory Science, Pathology, Clinical methods, Physical Examination
- Abstract
It is an important role of a clinical laboratory to provide accurate results of examinations promptly when a physician requires them, and this may be generally achieved. What more can technologists do to improve the medical service? It is more helpful for other medical staff to report crude laboratory data with adequate comments, which can be easily and promptly used in medical treatment. In this reversed clinicopathological conference, the admission periods of patients were divided into several phases: the admission day, from the 1st to 7th days, and from the 1st to 15th days. We closely analyzed routine laboratory data in each phase, and commented on what might be useful for the medical staff to the grasp the pathological state of patients in each phase. If comments from the laboratory become commonly acceptable, clinical laboratories will come to play a more valuable role in medical practice.
- Published
- 2014
74. Comprehensive whole-body counter surveys of Miharu-town school children for three consecutive years after the Fukushima NPP accident.
- Author
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Hayano RS, Tsubokura M, Miyazaki M, Satou H, Sato K, Masaki S, and Sakuma Y
- Subjects
- Adolescent, Age Distribution, Child, Food Contamination, Radioactive statistics & numerical data, Humans, Schools, Students, Surveys and Questionnaires, Data Collection, Fukushima Nuclear Accident, Nuclear Power Plants, Whole-Body Counting
- Abstract
Comprehensive whole-body counter surveys covering over 93% of the school children between the ages of 6 and 15 in Miharu town, Fukushima Prefecture, have been conducted for three consecutive years, in 2011, 2012 and 2013. Although the results of a questionnaire indicate that approximately 60% of the children have been regularly eating local or home-grown rice, in 2012 and 2013 no child was found to exceed the (137)Cs detection limit of 300 Bq/body.
- Published
- 2014
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75. Effects of organic solvent and solution temperature on electrospun polyvinylidene fluoride nanofibers.
- Author
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Wei K, Kim HK, Kimura N, Suzuki H, Satou H, Lee KH, Park YH, and Kim IS
- Abstract
In this study, the Poly(vinylidene fluoride-trifluoethylene) (PVDF) electrospun fibers were successfully prepared by electrospinning. Processing parameters, such as solvents and solution temperature were varied to study their influence on fiber dimensions. Electrospun PVDF fibers were characterized by scanning electron microscope (SEM), Fourier transform infrared spectrophotometer (FT-IR), wide angle X-ray diffraction (WAXD) and differential scanning calorimetry (DSC). The result indicated that the solvent component and temperature have great influence on fiber dimensions. 19% PVDF dissolved in DMF/MEK mixed solvents with the ratio of 8:2 was considered to be most suitable in this study. Furthermore, the increasing of solution temperature can probably induce the formation of beta-phases in electrospun PVDF Fibers.
- Published
- 2013
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76. Combination of pulse methylprednisolone infusions with cyclosporine-based immunosuppression is safe and effective to treat recurrent focal segmental glomerulosclerosis after pediatric kidney transplantation.
- Author
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Shishido S, Satou H, Muramatsu M, Hamasaki Y, Ishikura K, Hataya H, Honda M, Asanuma H, and Aikawa A
- Subjects
- Adolescent, Child, Child, Preschool, Drug Administration Schedule, Drug Therapy, Combination, Female, Follow-Up Studies, Glomerulosclerosis, Focal Segmental etiology, Humans, Infusions, Intravenous, Male, Recurrence, Treatment Outcome, Young Adult, Cyclosporine therapeutic use, Glomerulosclerosis, Focal Segmental drug therapy, Immunosuppressive Agents therapeutic use, Kidney Transplantation, Methylprednisolone therapeutic use, Postoperative Complications drug therapy
- Abstract
Background: Recurrence of focal segmental glomerulosclerosis (FSGS) in pediatric kidney allografts is associated with poor graft survival. Several therapeutic regimens have been proposed, with conflicting results., Methods: Ten pediatric patients with recurrent FSGS after kidney transplantation were treated with a protocol of methylprednisolone (MP) infusions in combination with cyclosporine (CsA)-based immunosuppression. The patients received a drug regimen with infusions of 20 mg/kg MP on three consecutive days at week 1, week 3, and week 5, and then monthly until six months after transplantation. If a complete or partial remission (PR) was obtained, MP pulse continued every three months until 24 months after transplantation. The CsA dose was adjusted according to AUC0-4., Results: Seven of 10 patients (70%) achieved complete remission (CR) with stable renal function within 18 months of beginning of treatment. One of two patients with PR entered CR 3.5 yr after transplantation. One patient lost her graft due to recurrence four months after transplantation. After observation for 26-119 months, seven patients maintained remission with normal glomerular filtration rate. Few major side effects were observed in association with the high-dose MP infusion therapy., Conclusions: MP infusion therapy in combination with CsA-based immunosuppression could be safe and effective in treating recurrent FSGS after kidney transplantation., (© 2013 John Wiley & Sons A/S.)
- Published
- 2013
- Full Text
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77. The impact of the 2011 Great East Japan Earthquake on hospitalisation for respiratory disease in a rapidly aging society: a retrospective descriptive and cross-sectional study at the disaster base hospital in Ishinomaki.
- Author
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Yamanda S, Hanagama M, Kobayashi S, Satou H, Tokuda S, Niu K, and Yanai M
- Abstract
Objective: To investigate the impact in an aging society of the 2011 Great East Japan earthquake on hospitalisation for respiratory disease at the disaster base hospital., Design: Descriptive and cross-sectional study., Setting: Emergency care in Japanese Red Cross Ishinomaki Hospital, a regional disaster base hospital in Miyagi, Japan., Participants: 322 emergency patients who were hospitalised for respiratory disease from 11 March to 9 May 2011, and 99 and 105 emergency patients who were hospitalised in the corresponding periods in 2009 and 2010, respectively., Main Outcome Measures: Description and comparison of patient characteristics and disease distribution in terms of age, time after the disaster and activities of daily living (ADL)., Results: 1769 patients were admitted to our hospital during the study period (compared to 850 in 2009 and 1030 in 2010), among whom 322 were hospitalised for respiratory disease (compared to 99 in 2009 and 105 in 2010). Pneumonia (n=190, 59.0%) was the most frequent cause of admission for pulmonary disease, followed by acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) (n=53, 16.5%), asthma attacks (n=27, 8.4%) and progression of lung cancer (n=22, 6.8%). Compared with the corresponding periods in 2009 and 2010, the increase in the absolute numbers of admissions was highest for pneumonia, followed by AE-COPD and asthma attacks. At hospitalisation, 195 patients were 'dependent' and 54 patients were 'partially dependent'. Respiratory admissions accompanied by deterioration of ADL after the disaster were more frequent in elderly and female patients., Conclusions: After the Great East Japan Earthquake, admissions for pneumonia and exacerbation of chronic respiratory disease in the elderly increased at the disaster base hospital.
- Published
- 2013
- Full Text
- View/download PDF
78. Internal radiocesium contamination of adults and children in Fukushima 7 to 20 months after the Fukushima NPP accident as measured by extensive whole-body-counter surveys.
- Author
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Hayano RS, Tsubokura M, Miyazaki M, Satou H, Sato K, Masaki S, and Sakuma Y
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Cesium Radioisotopes analysis, Child, Environmental Exposure analysis, Hospitals statistics & numerical data, Humans, Middle Aged, Time Factors, Young Adult, Data Collection, Fukushima Nuclear Accident, Nuclear Power Plants, Radiation Monitoring, Whole-Body Counting
- Abstract
The Fukushima Dai-ichi NPP accident contaminated the soil of densely-populated regions in Fukushima Prefecture with radioactive cesium, which poses significant risks of internal and external exposure to the residents. If we apply the knowledge of post-Chernobyl accident studies, internal exposures in excess of a few mSv/y would be expected to be frequent in Fukushima.Extensive whole-body-counter surveys (n = 32,811) carried out at the Hirata Central Hospital between October, 2011 and November, 2012, however show that the internal exposure levels of residents are much lower than estimated. In particular, the first sampling-bias-free assessment of the internal exposure of children in the town of Miharu, Fukushima, shows that the (137)Cs body burdens of all children (n = 1,383, ages 6-15, covering 95% of children enrolled in town-operated schools) were below the detection limit of 300 Bq/body in the fall of 2012. These results are not conclusive for the prefecture as a whole, but are consistent with results obtained from other municipalities in the prefecture, and with prefectural data.
- Published
- 2013
- Full Text
- View/download PDF
79. [Problem and assignment for distinguishing the Usher syndrome type].
- Author
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Iwasaki S, Yoshimura H, Takeichi N, Satou H, Ishikawa K, Kaga K, Kumakawa K, Nagai K, Furuya N, Ikezono T, Nakanishi H, Naitou Y, Fukushima K, Tono T, Kimitsuki T, Nishio S, Takumi Y, and Usami S
- Subjects
- Adult, Aged, Aged, 80 and over, Diagnosis, Differential, Female, Genetic Testing methods, Humans, Male, Middle Aged, Mutation genetics, Retinitis Pigmentosa diagnosis, Retinitis Pigmentosa genetics, Retrospective Studies, Usher Syndromes genetics, Usher Syndromes diagnosis
- Abstract
Usher syndrome is an autosomal-recessive disorder that causes bilateral sensorineural hearing loss, retinitis pigmentosa (RP), and occasionally vestibular dysfunction. Usher syndrome types 1, 2, and 3 can be distinguished by differences in audiovestibular features. The objectives of this retrospective study were to evaluate 26 patients with Usher syndrome clinically. The 26 patients (male: 12 cases, female: 14 cases) with Usher syndrome, with a clinical diagnosis based on symptoms of bilateral sensorineural hearing loss and RP, had been registered from 13 hospitals as a multicenter study. We assessed the clinical history and performed audiovestibular and ophthalmologic examinations, and genetic testing. Eleven of the patients were classified as having Usher type 1 (38.5%), 6 with Usher type 2 (23.1%), and 9 with Usher type 3 (38.5%). However, many patients with atypical Usher type 1 (70%) and type 2 (83.3%) were found compared with Usher type 3 (10%). The conductive rate of vestibular examinations including the caloric test (50%) was low. There were many variations in the clinical symptoms in Usher syndrome patients, therefore the classification of Usher types 1, 2, and 3 has been complicated. We have proposed a flowchart for the diagnosis of Usher types 1, 2, and 3.
- Published
- 2012
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80. Identifying prognostic factors in Japanese women with pseudomyxoma peritonei: a retrospective clinico-pathological study of the Tohoku Gynecologic Cancer Unit.
- Author
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Kojimahara T, Nakahara K, Shoji T, Sugiyama T, Takano T, Yaegashi N, Yokoyama Y, Mizunuma H, Tase R, Satou H, Tanaka T, Motoyama T, and Kurachi H
- Subjects
- Adult, Aged, Aged, 80 and over, Asian People, Female, Gynecology, Humans, Japan, Middle Aged, Oncology Service, Hospital, Peritoneal Neoplasms etiology, Peritoneal Neoplasms mortality, Peritoneal Neoplasms pathology, Prognosis, Pseudomyxoma Peritonei etiology, Pseudomyxoma Peritonei mortality, Pseudomyxoma Peritonei pathology, Retrospective Studies, Risk Factors, Survival Analysis, Peritoneal Neoplasms diagnosis, Pseudomyxoma Peritonei diagnosis
- Abstract
Pseudomyxoma peritonei (PMP) is a rare condition of mucinous ascites associated mainly with mucinous tumors of appendix or ovary. PMP often recurs after treatment and may eventually cause death by abdominal visceral dysfunction via compression with mucinous ascites. Although radical peritonectomy and hyperthermic intra-peritoneal chemotherapy are becoming popular globally, the optimal treatment of PMP has not been established in Japan. We conducted a retrospective multicenter study to clarify the optimal treatment and the prognostic factors of PMP. A total of 23 patients with PMP were analyzed in the Tohoku Gynecologic Cancer Unit (TGCU). Clinical and follow-up data were retrieved and a central pathology review was performed. The median follow-up period was 46 months. Eleven patients underwent complete resection. There were 7 deaths out of 13 recurrences/progressions in this period. All the recurrence/progression was confined to the abdomen. Unexpectedly, neither radical peritonectomy nor hyperthermic intra-peritoneal chemotherapy had been performed, indicating that both radical peritonectomy and hyperthermic intra-peritoneal chemotherapy are not yet popular in Japan. The medians of overall survival and disease-free period were 166 months and 30 months, respectively. Univariate and multivariate analyses revealed that the only prognostic factor was macroscopic residual tumor (P=0.022). Although chemotherapy was not a prognostic factor (P=0.16), those who received intra-peritoneal chemotherapy tended to have a better prognosis than those who received systemic or no chemotherapy (P=0.064). In conclusion, the macroscopic residual tumor is an important prognostic factor in Japanese patients with PMP.
- Published
- 2011
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81. Hemostatic effectiveness of a new application method for fibrin glue, the "rub-and-spray method", in emergency aortic surgery for acute aortic dissection.
- Author
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Minato N, Katayama Y, Yunoki J, Kawasaki H, and Satou H
- Subjects
- Aerosols, Aged, Aged, 80 and over, Anticoagulants adverse effects, Cardiopulmonary Bypass adverse effects, Circulatory Arrest, Deep Hypothermia Induced adverse effects, Female, Heparin adverse effects, Humans, Male, Middle Aged, Prospective Studies, Punctures adverse effects, Treatment Outcome, Aortic Dissection surgery, Aortic Aneurysm surgery, Blood Loss, Surgical prevention & control, Blood Vessel Prosthesis Implantation adverse effects, Fibrin Tissue Adhesive administration & dosage, Hemostasis, Surgical methods, Hemostatics administration & dosage
- Abstract
Purpose: This study was performed to evaluate the clinical hemostatic effectiveness of a new application method for fibrin glue, the rub-and-spray method, in aortic surgery., Methods: Twenty consecutive patients undergoing emergency ascending aorta or ascending-hemiarch replacement for Stanford type A acute aortic dissection were prospectively randomized into 2 groups, one with the rub-and-spray method (group G, 10 patients) and one without fibrin glue (group C, 10 patients). The rub-and-spray method consists of using a finger to rub the fibrinogen solution over needle holes, then spraying the fibrinogen solution and the thrombin solution simultaneously over the anastomosis, using an application nozzle. The number of bleeding needle holes at the proximal and distal anastomoses just after reperfusion, the hemostatic period (time from administration of protamine sulfate until closure of the pericardium), and the amounts of blood losses during this hemostatic period were measured., Results: The values in group G and group C were as follows: proximal needle holes (26.8 +/- 1.5, 26.4 +/- 2.4, p = 0.466); proximal bleeding needle holes (0.2 +/- 0.4, 19.3 +/- 3.5, p <0.001); distal needle holes (28.7 +/- 2.5, 27.8 +/- 4.4, p = 0.675); distal bleeding needle holes (1.3 +/- 1.2, 19.9 +/- 5.0, p <0.001); estimated bleeding proportion of the proximal needle holes (0.7 +/- 1.6%, 73.8 +/- 16.0%, p <0.001); estimated bleeding proportion of the distal needle holes (4.4 +/- 3.7%, 71.9 +/- 15.7%, p <0.001); estimated median hemostatic period (41.5 min [32-49], 51 min [44-89], p = 0.036); amounts of blood losses during this hemostatic period (99 +/- 76 ml, 257 +/- 163 ml, p = 0.016). The number of bleeding needle holes, the bleeding proportion of the proximal and distal needle holes, the hemostatic period, and the amounts of bleeding during this hemostatic period were significantly less in group G., Conclusion: This new application method for fibrin glue, the rub-and-spray method, revealed significant hemostatic effectiveness, even in hemostatically difficult surgery of acute aortic dissection that requires systemic heparinization and prolonged cardiopulmonary bypass with deep hypothermia.
- Published
- 2009
82. Atypical Cogan's syndrome with aortitis.
- Author
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Kondo Y, Ito S, Ohi Y, Satou H, Hiraoka T, Tsuboi H, Sugihara M, Hayashi T, Goto D, Matsumoto I, and Sumida T
- Subjects
- Adrenal Cortex Hormones therapeutic use, Aortitis diagnosis, Female, Humans, Keratitis diagnosis, Keratitis drug therapy, Meniere Disease diagnosis, Meniere Disease drug therapy, Middle Aged, Syndrome, Treatment Outcome, Vestibular Diseases diagnosis, Vestibular Diseases drug therapy, Aortitis complications, Keratitis complications, Meniere Disease complications, Vestibular Diseases complications
- Abstract
Cogan's syndrome is characterized by non syphilitic interstitial keratitis and Meniere's syndrome-like audiovestibular function disorder, as well as various systemic manifestations, including fever, arthralgia, vasculitis, and aortitis. We report the case of atypical Cogan's syndrome with aortitis; the patient's symptoms caused by active inflammation, including inflammatory ocular manifestations, audiovestibular symptoms, and aortitis, were improved by early administration of corticosteroids, however, her reduced visual acuity was not improved because of post-inflammatory change in her left eye.
- Published
- 2009
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83. A functionally separated nanoimprinting material tailored for homeotropic liquid crystal alignment.
- Author
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Gwag JS, Oh-E M, Kim KR, Cho SH, Yoneya M, Yokoyama H, Satou H, and Itami S
- Abstract
In order to homeotropically align liquid crystals (LCs) at the nanosized surface grooves processed by nanoimprint lithography technology (NIL), we propose to design a hybrid-type homeotropic polymer material consisting of two distinct moieties with largely different thermo-mechanical properties and surface activity. Surface contact angle measurements and sum-frequency vibrational spectroscopy allow us to conclude that the polymer film is a functionally separated composite suitable for the homeotropic LC alignment processed by NIL. As one of the potential applications using the hybrid-type homeotropic polymer, we demonstrate that the nanoimprinted grooves at the polymer surface can achieve a zenithal nematic LC bistability.
- Published
- 2008
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84. Hydration structures of bromides on cationic micelles.
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Harada M, Satou H, and Okada T
- Abstract
The peripheral structures of bromides on dodecyltrimethylammonium bromide (DTAB) and hexadecyltrimethylammonium bromide (HTAB) micelles have been studied by X-ray absorption fine structure (XAFS) at the Br-K edge. The XAFS spectra indicate that water is a dominant scattering group for Br- even in these micellar solutions. However, the oscillation intensity decreases with increasing micellar concentration, suggesting that the bromides are dehydrated to some extent when they are bound to the micelles. A XAFS analysis routine gives unusually short Br-O (water) distances and is inapplicable to the present systems. This comes from the structure of the first coordination shell, in which two or more scattering paths are involved. The second scattering group is obviously the head group of the surfactants forming the micelles. The detailed analysis has allowed us to estimate the hydration number of the bromides bound on the DTAB and HTAB micelles (N = ca. 4.2). The assumption that all of the bromides form direct ion-associates with the head groups causes the contradiction to the results of the XAFS analyses. This strongly implies that some of the bromides partitioned into the micelle are completely hydrated as far as their first coordination shell is concerned. Assuming that the maximum hydration number of the bromides bound to the head groups of the micelle is three, 40% of the bromides partitioned into the micelle are completely hydrated.
- Published
- 2007
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85. Coronary flow characteristics of multiple coronary artery-left ventricular microfistulae in young monozygotic twins.
- Author
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Itoi T, Satou H, and Hamaoka K
- Subjects
- Child, Coronary Vessels pathology, Fistula pathology, Heart Defects, Congenital pathology, Heart Ventricles pathology, Humans, Hypertrophy, Left Ventricular pathology, Male, Twins, Monozygotic, Coronary Circulation, Coronary Vessels physiopathology, Fistula physiopathology, Heart Defects, Congenital physiopathology, Heart Ventricles physiopathology, Hypertrophy, Left Ventricular physiopathology
- Abstract
Coronary artery multiple fistulae of the left ventricular chamber are extremely rare congenital malformations. We report on 13-year-old monozygotic twin brothers who have identical abnormalities of coronary flow reserve as well as the same morphological findings of multiple coronary fistulae of the 3 major coronary arteries to the left ventricular chamber. The left circumflex coronary artery (LCX) had abundant fine communications with the left ventricular chamber and had a higher flow rate than the left anterior-descending coronary artery. The coronary flow reserve obtained from the LCX was lower than the normal value matched for the same age group. The increased shunt flow resulted in enlargement of the left ventricular chamber. This is the first report of coronary flow characteristics in children with multiple coronary fistulae.
- Published
- 2007
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86. Reaction paths of the water-assisted solvolysis of N,N-dimethylformamide.
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Tsuchida N, Satou H, and Yamabe S
- Subjects
- Hydrolysis, Solubility, Thermodynamics, Dimethylformamide chemistry, Models, Chemical, Models, Molecular, Water chemistry
- Abstract
Density functional theory calculations were conducted on the title reactions with explicit inclusion of a variety of water molecules, H-CO-NMe2+MeOH+(H2O)n-->H-CO-OMe+HNMe2+(H2O)n. Geometries of transition states, reactant-like complexes and product-like ones were determined by the use of RB3LYP/6-31G(d) SCRF=dipole. Concerted paths were examined with n=0-3. Their Gibbs activation energies are larger than the experimental value. Stepwise paths were also investigated with n=2-4. The n=4 model has the energy close to the experimental value. However, when the catalytic water molecules were added to the n=4 one, the stepwise path was switched to the concerted one. A systematic comparison of the concerted path with n=2+1, 2+2, 2+3, 2+4, 2+5, 2+4+4, and 2+5+5 models was made, and the water-dimer based reaction path was found to be most favorable. The contrast between the concerted path of the amide solvolysis (and hydrolysis) and the stepwise one of the ester hydrolysis was discussed in terms of the frontier-orbital theory.
- Published
- 2007
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87. A new immunoglobulin-binding protein, EibG, is responsible for the chain-like adhesion phenotype of locus of enterocyte effacement-negative, shiga toxin-producing Escherichia coli.
- Author
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Lu Y, Iyoda S, Satou H, Satou H, Itoh K, Saitoh T, and Watanabe H
- Subjects
- Adhesins, Escherichia coli chemistry, Adhesins, Escherichia coli genetics, Amino Acid Sequence, Cells, Cultured, DNA Transposable Elements, Diarrhea immunology, Diarrhea microbiology, Enterocytes microbiology, Escherichia coli genetics, Escherichia coli isolation & purification, Escherichia coli Infections immunology, Escherichia coli Infections microbiology, Escherichia coli Proteins genetics, Humans, Lymphokines genetics, Molecular Sequence Data, Mutagenesis, Insertional, Phosphoproteins genetics, Transformation, Genetic, Adhesins, Escherichia coli metabolism, Bacterial Adhesion, Escherichia coli pathogenicity, Escherichia coli Proteins metabolism, Lymphokines metabolism, Shiga Toxin biosynthesis
- Abstract
Shiga toxin-producing Escherichia coli (STEC) are important enteropathogens causing severe diseases such as hemorrhagic colitis and hemolytic-uremic syndrome in humans. The majority of STEC strains of serogroups O157, O26, or O111 associated with severe cases of these diseases possess a pathogenicity island termed the locus of enterocyte effacement (LEE). LEE, which is responsible for the formation of attaching-and-effacing lesions on intestinal epithelial cells, is important for the full virulence of STEC. Nonetheless, LEE-negative STEC strains have repeatedly been reported to be associated with severe diseases in humans. In this study, we characterized adhesion to cultured epithelial cells of certain LEE-negative STEC isolated from humans with or without bloody diarrhea. Several LEE-negative STEC belonging to serogroup O91 showed an unusual, chain-like adhesion pattern to HEp-2 cells. Using Tn5-based transposon mutagenesis, we identified the gene essential for the chain-like adhesion phenotype of this O91 STEC strain. Sequence analysis of the Tn5-inserted allele identified a novel chromosomal open reading frame (ORF) encoding a polypeptide with a high degree of similarity to the E. coli immunoglobulin-binding (Eib) proteins EibA, -C, -D, -E, and -F. Therefore, the ORF was designated EibG. Laboratory E. coli strain MC4100 transformed with a multicopy plasmid carrying eibG showed chain-like adhesion to HEp-2 cells, and whole-cell lysates of the strain bound to human-derived immunoglobulin G (IgG) Fc and IgA. These results indicate that EibG acts as an IgG Fc- and IgA-binding protein, as well as an adhesin of LEE-negative STEC.
- Published
- 2006
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88. The GrlR-GrlA regulatory system coordinately controls the expression of flagellar and LEE-encoded type III protein secretion systems in enterohemorrhagic Escherichia coli.
- Author
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Iyoda S, Koizumi N, Satou H, Lu Y, Saitoh T, Ohnishi M, and Watanabe H
- Subjects
- Bacterial Adhesion physiology, DNA-Binding Proteins genetics, DNA-Binding Proteins metabolism, Endopeptidase Clp genetics, Endopeptidase Clp metabolism, Escherichia coli Proteins genetics, Flagellin genetics, Gene Deletion, Gene Expression Regulation, Bacterial, HeLa Cells, Humans, Operon genetics, Operon physiology, Phosphoproteins genetics, Repressor Proteins genetics, Trans-Activators genetics, Transcription, Genetic, Escherichia coli genetics, Escherichia coli metabolism, Escherichia coli Proteins metabolism, Flagellin metabolism, Phosphoproteins metabolism, Repressor Proteins metabolism, Trans-Activators metabolism
- Abstract
The gene function of the locus of enterocyte effacement (LEE) is essential for full virulence of enterohemorrhagic Escherichia coli (EHEC). Strict control of LEE gene expression is mediated by the coordinated activities of several regulatory elements. We previously reported that the ClpX/ClpP protease positively controls LEE expression by down-regulating intracellular levels of GrlR, a negative regulator of LEE gene expression. We further revealed that the negative effect of GrlR on LEE expression was mediated through GrlA, a positive regulator of LEE expression. In this study, we found that the FliC protein, a major component of flagellar filament, was overproduced in clpXP mutant EHEC, as previously reported for Salmonella. We further found that FliC expression was reduced in a clpXP grlR double mutant. To determine the mediators of this phenotype, FliC protein levels in wild-type, grlR, grlA, and grlR grlA strains were compared. Steady-state levels of FliC protein were reduced only in the grlR mutant, suggesting that positive regulation of FliC expression by GrlR is mediated by GrlA. Correspondingly, cell motility was also reduced in the grlR mutant, but not in the grlA or grlR grlA mutant. Because overexpression of grlA from a multicopy plasmid strongly represses the FliC level, as well as cell motility, we conclude that GrlA acts as a negative regulator of flagellar-gene expression. The fact that an EHEC strain constitutively expressing FlhD/FlhC cannot adhere to HeLa cells leads us to hypothesize that GrlA-dependent repression of the flagellar regulon is important for efficient cell adhesion of EHEC to host cells.
- Published
- 2006
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89. Reproducible on-off switching of solid-state luminescence by controlling molecular packing through heat-mode interconversion.
- Author
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Mutai T, Satou H, and Araki K
- Subjects
- Equipment Design, Equipment Failure Analysis, Materials Testing, Molecular Conformation, Phase Transition, Photochemistry instrumentation, Pyridines analysis, Reproducibility of Results, Crystallization methods, Hot Temperature, Luminescent Measurements instrumentation, Luminescent Measurements methods, Photochemistry methods, Pyridines chemistry, Signal Processing, Computer-Assisted instrumentation
- Abstract
Organic luminescent solids are attracting increasing interest in various fields of application. Modification or alteration of the chemical structures of their component molecules is the most common approach for tuning their luminescence properties. However, for dynamic tuning or switching of solid-state luminescence with high efficiency and reproducibility successful examples are limited as chemical reactions in the solid state frequently encounter insufficient conversion, one-way reactions or loss of their luminescence properties. One promising approach is to control the luminescence properties by altering the mode of solid-state molecular packing without chemical reactions. Here, we show that 2,2':6',2''-terpyridine, practically non-luminescent in the form of amorphous solid or needle crystal, shows strong blue luminescence upon formation of a plate crystal. Efficient and reproducible on-off switching of solid-state luminescence is demonstrated by heat-mode interconversion between the plate and needle crystals. Because alteration of the mode of molecular packing does not require chemical reactions, the present findings would open the way for the development of novel organic luminescent solids that can be switched on and off by external thermal stimuli.
- Published
- 2005
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90. Muscular polyarteritis nodosa as a cause of fever of undetermined origin: a case report and review of the literature.
- Author
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Kamimura T, Hatakeyama M, Torigoe K, Nara H, Kaneko N, Satou H, Yoshio T, Okazaki H, and Minota S
- Subjects
- Diagnosis, Differential, Glucocorticoids therapeutic use, Humans, Male, Middle Aged, Muscle, Skeletal pathology, Muscular Diseases pathology, Polyarteritis Nodosa drug therapy, Polyarteritis Nodosa pathology, Prednisolone therapeutic use, Fever of Unknown Origin etiology, Muscular Diseases etiology, Polyarteritis Nodosa complications
- Abstract
We describe an unusual presentation of a localized form of polyarteritis nodosa (PAN) manifested by fever of undetermined origin (FUO). Biopsies of the gastrocnemius muscle revealed necrotizing arteritis and initiation of prednisolone (PSL) brought rapid response. The PAN localized to muscle is rare; furthermore, this disease presented as FUO is very rare. We want to increase awareness that muscle can be also a single-affected site as well as other well known sites such as appendix, gallbladder, uterus or testis, and skin. Since there is no single appellation for this disease, we would like to propose the term "muscular PAN".
- Published
- 2005
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91. [Accuracy of quantitative coronary angiography for different directions of the coronary artery].
- Author
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Kageyama T, Satou T, Imazeki M, Satou H, Ueki S, Wakamatsu O, Amauchi H, and Nakazawa Y
- Subjects
- Humans, Phantoms, Imaging, Coronary Angiography methods
- Abstract
We evaluated the effect of changes in the direction of the coronary artery in terms of the accuracy and precision of vessel diameter measurement in a quantitative coronary angiography system (QCA system). Vessel phantoms sized 0.3, 0.5, 1.0, 1.5, 2.0, and 2.5 mm in diameter were evaluated. The phantoms were aligned on an acrylic plate, and the angle to the television (TV) camera was altered. The deployed angles were 0 (perpendicular), 45, 90, and 135 degrees in clockwise order. The phantoms were imaged with matrices of 1024 x 1024 (1024(2)), 512 x 512 (512(2)), and 512 x 1024. Image size was 7 inches, and the frame rate was 15 frames per second. Minimal lumen diameters were measured on the ACA system. The results revealed that, in the 1024(2) matrix, overall accuracy for the 90-degree angle was significantly underestimated compared with the 0-degree angle (-0.14 vs. -0.014 mm; p=0.007). Accuracy for the 90-degree angle was better than that for the 0-degree angle when the vessel diameter was 1 mm or smaller (-0.02+/-0.16 vs. 0.10+/-0.22 mm). In addition, precision was better at the 90-degree angle than with the other angles in the 1024(2) matrix (overall precision=0.002 mm). In the 512(2) matrix, overall accuracy for the 90-degree angle was significantly underestimated compared with the 45-degree angle (-0.077 vs. 0.096 mm; p=0.02). In addition, accuracy for the 90-degree angle was better than that for the 45-degree angle below 1 mm (0.05+/-0.24 mm vs. 0.26+/-0.47 mm). In terms of overall accuracy, the 45-degree angle in the 512(2) matrix showed significant overestimation compared with that in the 1024(2) matrix (0.096 vs. -0.069 mm; p=0.015). There was no difference in accuracy in the 512 x 1024 matrix. Our results suggest that the direction of the vessel against the TV image affects accuracy of measurement in the QCA system.
- Published
- 2005
- Full Text
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92. [NSE-positive lymphoblastic lymphoma in a boy with cutaneous involvement, giant splenomegaly, and hyper-gamma globulinemia].
- Author
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Takahashi K, Goi K, Satou H, Nemoto A, Uno K, Inukai T, Sugita K, and Nakazawa S
- Subjects
- Child, Humans, Hypergammaglobulinemia etiology, Male, Phosphopyruvate Hydratase blood, Precursor Cell Lymphoblastic Leukemia-Lymphoma complications, Skin pathology, Splenomegaly etiology, Precursor Cell Lymphoblastic Leukemia-Lymphoma diagnosis
- Abstract
We report a 6-year-old boy who was diagnosed as having neuron-specific enolase (NSE)-positive pro-T cell type lymphoblastic lymphoma preceded with a variety of symptoms such as skin rash, giant splenomegaly, and hyper-gamma globulinemia. He first showed cervical lymphadenopathy in June 1999, followed by a fever of unknown origin with atypical erythema, hepatosplenomegaly, and a few lymphoblastoid cells present in the bone marrow in September. However, no specific treatments were started at this point because a cervical lymph node biopsy failed to show malignancy and the patient's signs and symptoms resolved spontaneously. Two months later, oral prednisolone therapy was started due to recurrence of the fever and erythema, but resulted in exacerbation of the skin lesions and generalized lymphadenopathy. A biopsy of the right inguinal lymph node performed in January 2000 revealed proliferation of lymphoblastic cells positive for CD3, CD5 and NSE with a rearrangement of T cell receptor gene Jdelta, leading to the diagnosis of lymphoblastic lymphoma. After intensified chemotherapy, he received an autologous peripheral blood stem cell transplantation and has been in complete remission for 4 years.
- Published
- 2004
93. Six cases of children with a benign cervical tumor who required tracheostomy.
- Author
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Kitagawa H, Kawase H, Wakisaka M, Satou Y, Satou H, Furuta S, and Nakada K
- Subjects
- Airway Obstruction etiology, Child, Female, Fetal Diseases pathology, Glottis pathology, Hemangioma complications, Humans, Infant, Infant, Newborn, Laryngeal Neoplasms complications, Lymphangioma complications, Male, Neurilemmoma complications, Tongue Neoplasms complications, Tracheal Neoplasms complications, Airway Obstruction surgery, Head and Neck Neoplasms complications, Tracheostomy
- Abstract
Cervical tumors sometimes cause airway obstruction. We have treated six children with benign cervical tumors who required tracheostomy. Two cervical and one glossal lymphangiomata treated with local injection of OK432 after creating a tracheostomy were successfully decannulated after the treatment. One patient with a giant cervical lymphangioma needed an EXIT (ex utero intrapartum treatment) procedure. He underwent tracheostomy at 10 months of age after long-term endotracheal intubation, but he died of sepsis and hypoxic brain damage at 18 months. One patient with a subglottic hemangioma treated with steroids finally achieved closure of the tracheostomy at 2 years of age. A 7-year-old girl with a tracheal schwannoma underwent tracheostomy performed a week after admission, but she already had hypoxic brain damage resulting from problems with intubation. Most patients with a lymphangioma or hemangioma in the cervical region have required early tracheostomy before commencing treatment with OK-432 or steroids. If there is any sign of possible airway compromise, then it is vital to perform an early tracheostomy, even for benign tumors.
- Published
- 2004
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94. Maturity-onset diabetes of the young resulting from a novel mutation in the HNF-4alpha gene.
- Author
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Hara K, Noda M, Waki H, Tobe K, Yamauchi T, Kadowaki H, Satou H, Tsukamoto K, Nagamatsu S, Yamagata K, Matsuzawa Y, Akanuma Y, Kimura S, and Kadowaki T
- Subjects
- Adult, Age of Onset, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Blood Glucose analysis, DNA-Binding Proteins genetics, Diabetes Mellitus, Type 2 physiopathology, Female, Genes, Dominant genetics, Glucose Tolerance Test, Hepatocyte Nuclear Factor 4, Humans, Middle Aged, Pedigree, Transcription, Genetic physiology, Diabetes Mellitus, Type 2 genetics, Mutation, Phosphoproteins genetics, Transcription Factors genetics
- Abstract
A 52-year-old woman with early-onset diabetes mellitus, severe diabetic retinopathy, and a family history of a dominant inheritance pattern was referred to our hospital. Direct sequencing revealed a novel mutation in the HNF-4alpha gene (R244Q). The position of the mutation in the amino-acid sequence of the gene is well conserved among species and transcriptional activity of the mutant gene was significantly reduced. Therefore, a diagnosis of maturity-onset diabetes of the young (MODY)-1 was made. Genetic testing enabled early diagnosis of diabetes in the patient's 20-year-old daughter, which we consider to be important for the prevention of diabetic complications.
- Published
- 2002
- Full Text
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95. Aortic valve replacement combined with endoventricular circulatory patch plasty (Dor operation) in a patient with aortic valve stenosis and severe ischemic cardiomyopathy.
- Author
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Horiguchi K, Ohtake S, Matsumiya G, Sawa Y, Nishimura M, Satou H, Kawai N, and Matsuda H
- Subjects
- Aortic Valve Stenosis physiopathology, Cardiomyopathy, Dilated complications, Female, Heart Valve Prosthesis, Heart Ventricles surgery, Humans, Middle Aged, Myocardial Ischemia complications, Suture Techniques, Ventricular Dysfunction, Left etiology, Aortic Valve Stenosis surgery, Ventricular Dysfunction, Left surgery
- Abstract
A 58-year-old woman with ischemic cardiomyopathy and aortic valve stenosis, underwent aortic valve replacement and simultaneous endoventricular circulatory patch plasty (Dor operation). She underwent coronary artery bypass grafting for severe triple vessel disease 10 years ago. Recently she started to show severe congestive heart failure. Aortic valve stenosis with pressure gradient of 85-mmHg was also found. Coronary bypasses were all patent, but the left ventricle (LV) was severely dilated (LVDd/Ds=71/61 mm) and the ischemic cardiomyopathy was considered as the cause. She successfully underwent aortic valve replacement and endoventricular circulatory patch plasty. The initial postoperative course was complicated with intractable ventricular arrhythmia, but subsequent course was smooth and the patient was discharged with improved symptoms (NYHA Class II). Postoperative catheterization showed decreased left ventricular volume and improved contractility. This case implies the role of LV remodeling procedure in the ischemic cardiomyopathy combined with aortic valve lesion
- Published
- 2001
96. Intraosseous meningioma of the posterior fossa--Case report.
- Author
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Yamazaki T, Tsukada A, Uemura K, Satou H, Tsuboi K, and Nose T
- Subjects
- Cerebral Angiography, Cranial Fossa, Posterior diagnostic imaging, Epidural Space, Humans, Magnetic Resonance Imaging, Male, Meningeal Neoplasms diagnostic imaging, Meningeal Neoplasms surgery, Meningioma diagnostic imaging, Meningioma surgery, Middle Aged, Occipital Bone diagnostic imaging, Skull Neoplasms diagnostic imaging, Skull Neoplasms surgery, Tomography, X-Ray Computed, Cranial Fossa, Posterior pathology, Meningeal Neoplasms pathology, Meningioma pathology, Occipital Bone pathology, Skull Neoplasms pathology
- Abstract
A 62-year-old male presented with a rare intraosseous meningioma with intradural extension manifesting as frequent vomiting and floating sensation that had persisted for 3 months. Neuroimaging detected a mass lesion that was mainly located extradurally in the right posterior fossa with a daughter lesion inside the dura. He underwent surgical excision of the mass lesion. Craniectomy exposed the main lesion of the tumor just beneath the thinned outer table of the skull, and in the extradural space, with the daughter lesion penetrating the dura. Both portions of the tumor were resected. There was no attachment to the adjacent dura mater. Histological examination showed meningotheliomatous meningioma containing scattered bony tissue. This intraosseous meningioma probably originated from the occipital bone with a small intradural extension caused by mechanical compression.
- Published
- 2001
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97. Isolated left coronary ostial stenosis as a result of fibromuscular dysplasia in a young man.
- Author
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Kawakami H, Matsuoka H, Koyama Y, Saeki H, Inoue K, Nishimura K, Itou T, Satou H, and Tomino T
- Subjects
- Adult, Angina Pectoris etiology, Angina Pectoris pathology, Angina Pectoris surgery, Coronary Angiography, Coronary Disease pathology, Coronary Disease surgery, Fibromuscular Dysplasia pathology, Fibromuscular Dysplasia surgery, Humans, Male, Coronary Disease etiology, Fibromuscular Dysplasia complications
- Abstract
A 28-year-old man was admitted to hospital for investigation of a 2-week history of angina occurring on exertion. Coronary angiography showed an isolated left coronary ostial stenosis and left main trunk plasty was performed 2 weeks later. The pathological diagnosis of the left coronary ostial stenosis was fibromuscular dysplasia, which makes this a rare case.
- Published
- 2000
- Full Text
- View/download PDF
98. Effects of micro-encapsulation on morphology and endocrine function of cryopreserved neonatal porcine islet-like cell clusters.
- Author
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Murakami M, Satou H, Kimura T, Kobayashi T, Yamaguchi A, Nakagawara G, and Iwata H
- Subjects
- Animals, Animals, Newborn, Cell Survival, Cells, Cultured, Cryopreservation, Female, Insulin metabolism, Insulin Secretion, Islets of Langerhans Transplantation pathology, Male, Survival Rate, Swine, Drug Compounding, Islets of Langerhans cytology, Islets of Langerhans physiology
- Abstract
Background: For the success of clinical islets transplantation, the development of a long-term storage method is necessary. However, the structure of digested islets is scanty for culture and cryopreservation. In this study, the effect of micro-encapsulation to cryopreserved porcine islet-like cell clusters (ICCs) was investigated., Methods: The ICCs prepared from neonatal pigs by collagenase digestion and culture technique were cryopreserved and micro-encapsulated in 5% agarose membranes. After cryopreservation, ICC cultured without encapsulation (group A) and cultured with encapsulation (group B) were assessed by comparison with no cryopreserved ICC (control) both in vitro by static incubation test and in vivo in a xenotransplantation study., Results: Micro-encapsulation was able to maintain the fine morphology and the number of ICCs of group B after 7 days of culture. There were not significant differences in insulin secretion of group B and control on day 1 and 7 of culture (1 day:11+/-0.99, 7 days: 5.30+/-1.08 microU/ICC/hr NS versus control). On day 7 of culture, the retrieval rate of group B (105.2+/-9.8%) is obviously higher compared with group A (63.0+/-6.3%). In the xenotransplatation model, the ICCs of group B showed long survival time (7.9+/-0.4 weeks) and good transplantation effect., Conclusion: Our study suggests that micro-encapsulation is one of the useful method for cryopreserved ICC to maintain the fine morphology and effectively recover the endocrine function.
- Published
- 2000
- Full Text
- View/download PDF
99. Three-dimensional imaging of aortic aneurysm after balloon angioplasty for coarctation of the aorta.
- Author
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Hamaoka K, Satou H, Sakata K, and Onouchi Z
- Subjects
- Adolescent, Aortic Aneurysm, Abdominal etiology, Aortic Aneurysm, Abdominal surgery, Aortic Valve Stenosis etiology, Aortic Valve Stenosis surgery, Aortography, Female, Heart Septal Defects, Ventricular surgery, Humans, Magnetic Resonance Imaging, Postoperative Complications etiology, Postoperative Complications surgery, Angioplasty, Balloon adverse effects, Aortic Aneurysm, Abdominal diagnostic imaging, Aortic Coarctation surgery, Tomography, X-Ray Computed methods
- Published
- 1999
- Full Text
- View/download PDF
100. Surgical removal of a stent entrapped in the left main coronary artery.
- Author
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Fukada J, Morishita K, Satou H, Shiiku C, Koshino T, and Abe T
- Subjects
- Aged, Angioplasty, Balloon, Coronary, Aorta, Thoracic diagnostic imaging, Coronary Angiography, Coronary Disease diagnostic imaging, Coronary Disease therapy, Coronary Vessels surgery, Foreign-Body Migration diagnostic imaging, Foreign-Body Migration etiology, Humans, Male, Prosthesis Failure, Reoperation, Aorta, Thoracic surgery, Coronary Artery Bypass, Foreign-Body Migration surgery, Stents adverse effects
- Abstract
A stent entrapped in the coronary artery, which can not be removed by a trans-catheter approach, is extremely rare but is the biggest problem cardiologists face. Surgical retrieval appears to be the only possible treatment to avoid sudden death due to stent thrombosis. We experienced with a New Parmaz-Schatz stent entrapped in the left main coronary artery (LMT) of a 65-year-old man. He underwent surgical removal of the stent with ascending aorta incision and double coronary artery bypass grafting (CABG) using saphenous veins. We believe that a stent entrapped in the LMT must be removed as rapidly as possible to avoid sudden death. Furthermore, in order to avoid the risk of peripheral thrombosis, retrieval is also the case in patients whose distal coronary flow can be maintained with CABG.
- Published
- 1998
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