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54. Modelling of the microstructural evolution of Ti6Al4V parts produced by selective laser melting during heat treatment

Author

Billington , D., Leach, R. K., Phillips , D., Riemer , O., Savio, E., De Baere, David, Valente, Emilie Hørdum, Mohanty, Sankhya, Hattel, Jesper Henry, Billington , D., Leach, R. K., Phillips , D., Riemer , O., Savio, E., De Baere, David, Valente, Emilie Hørdum, Mohanty, Sankhya, and Hattel, Jesper Henry

Abstract

The microstructure of parts produced by sective laser melting of Ti-6Al-4V is typically martensite in elongated prior β grains, which leads to anisotropic mechanical properties. A heat treatment can reduce this anisotropy by making these grains more equiaxed. In this work, simulations are performed wherein the evolution of the microstructure during a heat treatment is modelled using a cellular automata method. The results obtained from this simulation are compared to experimentally obtained micrographs. The simulated microstructure shows a similar evolution of the prior β grains from columnar to equiaxed, although the average diameter of the grains is slightly smaller in the simulations.

Published
2018

55. Automated contact area measurement on structured surfaces

Author

Billington, D., Leach, R. K., Phillips, D., Riemer, O., Savio, E., Kücükyildiz, Ömer C., Jensen, Sebastian H. N., De Chiffre, Leonardo, Billington, D., Leach, R. K., Phillips, D., Riemer, O., Savio, E., Kücükyildiz, Ömer C., Jensen, Sebastian H. N., and De Chiffre, Leonardo

Abstract

Structured surfaces involved in a tribological test are quantified using an automated contact area measurement method. The method involves an image segmentation algorithm based on local image gradient extrema. The gradients are then used to accurately determine band-edge segmentation in order to measure the line thickness of the structured surfaces. The traceability of the method was established through an optical standard from NPL in the line-thickness range 10 -100 μm achieving expanded uncertainties in the range 0.5-1.9 μm. The specimen line thickness of different combinations of asperity angle and deformation load, were subject to 10 repeated automatic measurements. The combination of the parameters produce different contact areas, which are interesting for the tribological properties of the surfaces.

Published
2018

56. Thermal behaviour of additively manufactured injection moulding inserts

Author

Billington, D., Leach, R. K., Phillips, D., Riemer, O., Savio, E., Hofstätter, Thomas, Pedersen, David B, Tosello, Guido, Hansen, Hans N, Billington, D., Leach, R. K., Phillips, D., Riemer, O., Savio, E., Hofstätter, Thomas, Pedersen, David B, Tosello, Guido, and Hansen, Hans N

Abstract

Injection moulding using inserts from vat polymerization, an additive manufacturing technology, has been investigated for pilot production and rapid prototyping purposes throughout the past years. Experiments have used a standard mould is equipped with additively manufactured inserts in a rectangular shape of (20 x 20 x 2.7) mm3 produced with vat photo polymerisation. While the lifetime compared to conventional materials such as brass, steel, and aluminium, is reduced, the prototyping and design phase can be shortened significantly by using flexible and cost-effective additive manufacturing technologies. While crack propagation has been significantly reduced, further developments become possible, such as multi-scale injection moulding inserts with dimensions of (80 x 60 x 10) mm3 where an insert with larger outside dimensions and micro features on the surface is used during the manufacturing process. Higher manufacturing volume still exceed the capability of additively manufactured inserts, which are overruled by the stronger performance of less-flexible but stronger materials. This contribution discusses the heat transportation within the inserts made from a thermoset material, brass, steel, and ceramic material. It therefore elaborates on the possibilities of injection moulding as well as the thermal challenges connected with the use of polymer inserts. They are an essential part for further calibrations of the injection moulding process.

Published
2018

57. Evaluation of part consistency with photopolymer inserts in different injection moulding process parameters

Author

Billington, D. Billington, Leach, R. K., Phillips, D., Riemer, O., Savio, E., Davoudinejad, Ali, Charalambis, Alessandro, Zhang, Yang, Calaon, Matteo, Tosello, Guido, Hansen, Hans Nørgaard, Billington, D. Billington, Leach, R. K., Phillips, D., Riemer, O., Savio, E., Davoudinejad, Ali, Charalambis, Alessandro, Zhang, Yang, Calaon, Matteo, Tosello, Guido, and Hansen, Hans Nørgaard

Abstract

Using additive manufacturing (AM) processes for direct fabrication of complex three-dimensional objects in a fewer time incomparison to the subtractive method is the advancement of this technology. This study connecting the AM with injection moulding (IM) process. AM inserts are directly manufactured by photopolymer material and used in IM process. Different combinations of IM parameters are used in order to find out the influence of various settings on the fabrication of the parts with soft inserts. The effects of injection moulding parameters are investigated by the use of a design of experiment (DOE) and optical metrology. DOE analysis concludes that the IM speed and cooling time are significant factors, for the geometry of the features. The height of bricks and knobsare also measured on the IM parts for assessment of different batches before any cracks appear on the inserts.

Published
2018

58. Post moulding thermal characterization of polymer components

Author

Billington, D., Leach, R. K., Phillips, D., Riemer, O., Savio, E., D. Costa, G., González-Madruga, D., De Chiffre, L., Billington, D., Leach, R. K., Phillips, D., Riemer, O., Savio, E., D. Costa, G., González-Madruga, D., and De Chiffre, L.

Abstract

Industries seek to anticipate product dimensional measurements to quickly control the process and ensure production conformity. The anticipation of the dimensional measurement is often prevented due to dimensional instabilities of the produced parts. In the case of injection moulded polymer components, one of the main instabilities is represented by expansion due to temperature changes. This work proposes a methodology consisting in the prediction of the dimensions at reference temperature conditions using information from measurements performed within few minutes from the moulding process. An industrial component consisting of a thin wall tubular part made of POM (polyoxymethylene) has been selected for the investigation. The measuring equipment included an inductive probe, two thermocouples for concurrent measurements of length and temperature. The dimension at reference temperature conditions is estimated using the information from the transitory cooling period subsequent to the moulding process and through the definition of an apparent coefficient of thermal expansion. Further development of themethodology must be introduced to tackle other dimensional instabilities, such as hygroscopic swelling, stress relaxation and recrystallization.

Published
2018

59. Applicability of Acoustic Emission monitoring to micro polishing

Author

Billington, D., Leach, R. K., Phillips, D., Riemer, O., Savio, E., Ben Achour, Soufian, Bissacco, Giuliano, De Chiffre, L., Billington, D., Leach, R. K., Phillips, D., Riemer, O., Savio, E., Ben Achour, Soufian, Bissacco, Giuliano, and De Chiffre, L.

Abstract

Application of process monitoring solutions to micro polishing is affected by the low intensity of the measured signals, which influences the capability to extract useful information. This work explores the applicability of acoustic emission monitoring for detection of process completion through End Point Detection (EPD) in micro polishing. Several polishing tests have been conducted by gradually reducing the contact area and the acoustic emission signal generated by the process is acquired and analysed. The work shows that the monitoring solutions applied in conventional polishing can potentially be applied to the micro process.

Published
2018

60. Numerical modelling and parametric study of grain morphology and resultant mechanical properties from selective laser melting process of Ti6Al4V

Author

Billington , D., Leach, R. K., Phillips , D., Riemer , O., Savio, E., Bayat, Mohamad, Mohanty, Sankhya, Hattel, Jesper H., Billington , D., Leach, R. K., Phillips , D., Riemer , O., Savio, E., Bayat, Mohamad, Mohanty, Sankhya, and Hattel, Jesper H.

Abstract

In this paper, a transient 3-dimensional thermal model for the selective laser melting process, based on the finite volume method, has been developed, which takes into account the phase change and powder to bulk material transition. A parametric study has been performed for the temperature field as well as the melt pool dimensions, and the results show the impact on melt pool size. Also, in this paper, a straightforward metallurgical model has been coupled to a thermal model, which uses the temperature gradient and the cooling rate on the melt pool borders at the onset of solidification to determine whether the grains have columnar or equiaxed morphology. Furthermore, the effect of process parameters on the size of grains and subsequently the yield stress has been studiedvia empirical equations. The results show that low speed along with high laser power (higher laser energy density) will cause low cooling rates and prompt the formation of large grain. This would consequently give rise to lower tensile strength, as compared tolower laser energy density where smaller grains are formed due to higher cooling rates.

Published
2018

61. Numerical simulation of extrusion-based additive manufacturing - Effect of the nozzle geometry on the strand cross-section

Author

Billington , D., Leach, R. K., Phillips , D., Riemer , O., Savio, E., Comminal, Raphaël, Serdeczny, Marcin P., Pedersen, David B., Spangenberg, Jon, Billington , D., Leach, R. K., Phillips , D., Riemer , O., Savio, E., Comminal, Raphaël, Serdeczny, Marcin P., Pedersen, David B., and Spangenberg, Jon

Abstract

The shape of the printed strand in extrusion-based additive manufacturing is an important factor that affects the surface roughness and the geometrical accuracy of the 3D printing fabrication. We used Computational Fluid Dynamics simulations to investigate the effect of the geometry of the extrusion nozzle on the cross-section of the printed strand. The extrusion of a single thread on a planar surface was modelled as an isothermal incompressible Newtonian fluid flow. The deposition of the strand is a creeping flow that solely depends on the geometry of the nozzle, the gap and the ratio of the extrusion speed to the printing speed. We considered three different nozzle geometries: a cylindrical nozzle, a square nozzle, and a cylindrical nozzle with a side plate extension retaining side flows. The numerical simulations provided the cross-section of the deposited strand as well as the printing force applied by the extruded material on the substrate. The side plate improved the compactness of the strand cross-section, while the square nozzle did not present any advantage as compared to the cylindrical nozzle, in the printed configuration that we considered.

Published
2018

62. Pitch measurements validation of a structural coloured steel insert using Scanning Confocal Microscopy (SCM) and Atomic Force Microscopy (AFM)

Author

Billington , D., Leach, R. K., Phillips , D., Riemer, O., Savio, E., Loaldi, Dario, Zhang, Yang, Calaon, Matteo, Yang, Yang, Guochin, Ping, Garnæs, Jørgen, Tosello, Guido, Billington , D., Leach, R. K., Phillips , D., Riemer, O., Savio, E., Loaldi, Dario, Zhang, Yang, Calaon, Matteo, Yang, Yang, Guochin, Ping, Garnæs, Jørgen, and Tosello, Guido

Abstract

The optical principle of structural colouration provides to a surface unnatural and iridescent colouring properties. Surface topographycombined with lighting characteristics are the physical driver of the phenomenon. Structural colouring arises from the presence on the specimen of nanoscale features distanced by a length comparable to the near visible light spectrum (300‐1000 nm). The microstructures behave as a bandpass filter for certain light wavelengths, enabling an unnatural colouring effect. Elliptical Vibration Texturing (EVT) is an on development technology for fast texturing of gratings on metal inserts for structural colouration purposes.To identify the accuracy of EVT, in this study, two different microscopes assess an EVT grating with a 1000 nm nominal pitch on asteel flat surface. On first, optical‐based metrology is selected adopting a Laser Scanning Confocal Microscope (SCM) with a 405 nm blue source to tackle the measuring purpose. Secondly, an Atomic Force Microscope (AFM) in Intermittent contact mode (IC‐AFM) isadopted. Considering the differences in set‐up time and scanning range, the objective of this research is to identify the mostfavourable measuring technique.On the sample images, five average profiles on different locations provide consistent information about the process repeatability.Pitch estimation comes by means of FFT algorithm on the extracted profiles. The average result for SCM measures is 1002 ± 31 nmwhile for AFM is 972 ± 15 nm. At last, from these results, the estimation of EVT accuracy is presented.

Published
2018

63. Influence of thermal ageing on the mechanical properties of an additively manufactured photopolymer used in soft tooling applications

Author

Billington , D., Leach, R. K., Phillips , D., Riemer , O., Savio, E., Mischkot, Michael, Krexner, Gerhard, Soprunyuk, Viktor, Schranz, Wilfried, Pedersen, David Bue, Tosello, Guido, Billington , D., Leach, R. K., Phillips , D., Riemer , O., Savio, E., Mischkot, Michael, Krexner, Gerhard, Soprunyuk, Viktor, Schranz, Wilfried, Pedersen, David Bue, and Tosello, Guido

Abstract

In recent years, direct rapid soft tooling based on inserts manufactured additively by light reactive photopolymer curing has become a solid alternative to classic tooling based on subtractive machining of metals for prototyping and pilot production of polymer parts by injection moulding. Reported numbers of injection-moulded parts per insert are in the low to medium three-digit range. This, however, is based on using additive manufacturing for the production of both mould halves. It was found that combining a soft tooling insert on one mould half and a metal insert on the other half can increase insert lifetime to more than 10 000 parts in acrylonitrile butadiene styrene (ABS) with a negligible influence of insert wear on the dimensional stability of the injection-moulded parts. Photopolymers are known for their very low heat conductivity compared to metals and their sensitivity to elevated temperatures leading to degradation and negative effects on their mechanical properties. Considering heat transfer laws, it can be assumed that most thermal energy brought into the cavity during the plastic injection is conducted away through the steel half of the mould, thus leading to a significant reduction of the thermal ageing of the photopolymer insert. This research supports the quantification of the influence of thermal ageing on insert lifetime by performing experiments with photopolymer samples aged thermally after exposure to different elevated temperature levels for different time spans.

Published
2018

64. A new design for an extensive benchmarking of additive manufacturing machines

Author

Billington , D., Leach, R. K., Phillips , D., Riemer , O., Savio, E., Moshiri, Mandaná, Tosello, Guido, Mohanty, Sankhya, Billington , D., Leach, R. K., Phillips , D., Riemer , O., Savio, E., Moshiri, Mandaná, Tosello, Guido, and Mohanty, Sankhya

Abstract

This paper focuses on a new methodology for conducting a comprehensive benchmarking of Additive Manufacturing (AM) technologies. The quality of the built products using AM strongly depends on the machine capabilities, and it is thus essential to develop a proper benchmarking design that would allow their comparative evaluation. The benchmarking presented has been designed with the purpose of conducting a comparison between different AM machines, with a particular focus on metal powder-bed AM. The main scope is to make an extensive evaluation of the technologies from multiple points of view, covering: accuracy and precision of the machine, residual stresses on the parts (particularly important in the case of metal AM), homogeneity (in terms of density and residual porosity), build speed, mechanical properties, surface finish and corrosion resistance. For each evaluation criteria, a specific analysis method is employed. The aim of this work is to analyse the current technology capabilities and limitations, in order to assess what different AM machines can deliver in a net-shape process chain scenario. The benchmark is employed for a statistically designed series of experiments to study in detail the AM machine´s real limitations and their working process windows. The design also includes features that represent a challenge for the AM machine, and sometimes exceed the machine´s actual capabilities. Furthermore, the benchmark has been developed to be used as a periodic quality control-job for the operational performance of the AM machines.

Published
2018

65. Application of modelling tools for precise transfer of nanostructures from silicon wafers to steel injection moulding tool inserts

Author

Billington , D., Leach, R. K., Phillips , D., Riemer , O., Savio, E., Sonne, M. R., Hattel, J. H., Billington , D., Leach, R. K., Phillips , D., Riemer , O., Savio, E., Sonne, M. R., and Hattel, J. H.

Abstract

Functional nanostructures applied on various consumer products has attracted increasing attention in the industry. Examples of functional nanostructures are well known from nature, where organisms and plants possess optical, adhesive, and self-cleaning capabilities. The aim of the present work is to produce injection moulding tool inserts with the nanostructured functional surfaces as mentioned above. In order to manufacture these structures on the double-curved surfaces of the injection moulding tool inserts, a technology called nanoimprint lithography (NIL) with flexible stamps is applied. However, the resolution limit due to distortion of the stamp when applying the pressure, and complications regarding deformations of the flexible stamp, is a major concern for precise replication of the nanostructures whose functionality might change dramatically with just a few nanometres of distortion. Here, the application of modelling tools is essential in order to predict how the flexible stamp will deform during the transferring process. However, such models are quit complicated since the overall behaviour is non-linear. A review of different manufacturing and simulation cases will be presented and gives an overview of today’s methodologies for transfer of nanostructures to curved surfaces.

Published
2018

66. Considerations on numerical modelling for compensation of in-process metrology in manufacturing

Author

Billington , D. Billington, Leach, R. K., Phillips , D., Riemer, O., Savio, E., Sonne, M. R., Mohammadi, A., Dalla Costa, G., Madruga, D. G., De Chiffre, L., Hattel, J. H., Billington , D. Billington, Leach, R. K., Phillips , D., Riemer, O., Savio, E., Sonne, M. R., Mohammadi, A., Dalla Costa, G., Madruga, D. G., De Chiffre, L., and Hattel, J. H.

Abstract

The growing demands for quality and flexibility and at the same time production speed challenges conventional metrology. The future tendency is that metrology is an integrated part of the production line and thus is placed in a production environment. This is a challenge since dimensional metrology in a production environment might lead to higher uncertainties due to dynamic variations both in the conditions of the environment and in the conditions produced parts, with all the influencing factors such as temperature, vibrations, forces and humidity etc. that lies outside the requirements from todays standards referring to 20oC and 0 N (zero forces acting on the part). However, many of these effects can be treated as systematic errors if the physical phenomena leading to the deviations can be described. Today, it is very common to compensate for the variations in temperature in a classical 1D manner where a measurand is compensated via the coefficient of thermal expansion (CTE) and the difference from the reference temperature. However, when temperature gradients and very complex part geometries exist the deformation pattern might not at all follow a linear path. Instead, more advanced three-dimensional thermomechanical numerical models should be used for predicting the deformation of the parts due to the thermal effects taking the inherent build-up of residual stresses and warpage into account. The same goes for other effects that might change the dimensions over time such as hygroscopic swelling (for polymer parts), which can be taken into account by considering numerical modelling. In the present work, different academic and industrial parts will be used as cases in order to show the advantages of using numerical simulation tools for compensation of the dynamic changes and further also highlight and discuss where the classical 1D approaches might be sufficient for a desired uncertainty.

Published
2018

67. Process parameter influence on Electro-sinter-forging (ESF) of titanium discs

Author

Billington, D., Leach, R. K., Phillips, D., Riemer, O., Savio, E., Cannella, Emanuele, Nielsen, Chris Valentin, Bay, Niels, Billington, D., Leach, R. K., Phillips, D., Riemer, O., Savio, E., Cannella, Emanuele, Nielsen, Chris Valentin, and Bay, Niels

Abstract

Electro-sinter-forging (ESF) is a sintering process based on the resistance heating principle, which makes it faster than conventional sintering. The process is investigated as a function of the main process parameters, namely compacting pressure, electrical current density and sintering time. The present work is focused on analysing the influence of these process parameters on the final density of a disc sample made from commercially pure titanium powder. Applying the design of experiments (DoE) approach, the electrical current was seen to be of largest influence. The maximum obtained density was 94% of the bulk density of pure titanium. Density measurements were carried out by measuring the mass and volume separately. The volume was estimated applying two methods, namely the Archimedes’ suspension method and 3D scanning to build and measure the volume mesh of the sample. The density calculations proved to be compatible.

Published
2018

68. Assessment of sub-mm features replication capability in injection moulding using a multi-cavity tool produced by additive manufacturing

Author

Billington, D., Leach, R. K., Phillips, D., Riemer, O., Savio, E., Davoudinejad, Ali, Charalambis, Alessandro, Tosello, Guido, Zhang, Yang, Calaon, Matteo, Pedersen, David Bue, Hansen, Hand Nørgaard, Billington, D., Leach, R. K., Phillips, D., Riemer, O., Savio, E., Davoudinejad, Ali, Charalambis, Alessandro, Tosello, Guido, Zhang, Yang, Calaon, Matteo, Pedersen, David Bue, and Hansen, Hand Nørgaard

Abstract

This research investigates the effect of injection moulding process parameters on photopolymer mould inserts produced with the Digital Light Processing (DLP) additive manufacturing (AM) method. The main motivation of applying AM to produce mould inserts, is the potential of reducing lead time and manufacturing cost, as well as achieving a more flexible manufacturing method in case of non-mass produced products such as prototypes. In this research moulds inserts of 20 x 20 x 2.7 mm with mould cavities as small as 5 x 4 mm in dimensions are tested. The parts are analyzed and evaluated by the measurements of different features and the influence of the IM process.

Published
2018

69. Prediction of micro-sized flash using micro-injection moulding process simulations

Author

Billington , D., Leach, R. K., Phillips , D., Riemer, O., Savio, E., Baruffi, Federico, Calaon, Matteo, Tosello, Guido, Billington , D., Leach, R. K., Phillips , D., Riemer, O., Savio, E., Baruffi, Federico, Calaon, Matteo, and Tosello, Guido

Abstract

In micro-manufacturing, the accurate prediction of defects affecting the part quality by means of process simulations is of paramount importance. With this purpose, micro-injection moulding process simulations can be fundamental with the aim of strongly reducing experimental and quality assurance efforts. In this study, the usage of process simulations for the prediction of the size of the flash affecting an ultra-small three-dimensional polyoxymethylene (POM) micro component is discussed. A three-dimensional multi-scale mesh was used to discretize a geometry comprising the part and the feed system of the one-cavity micro mould. The venting channel was included into the model in order to simulate the flash formation as a virtual short-shot. Simulation were run with Autodesk Moldflow Insight 2017® and results validated by comparing numerical results with experimental observation of the flash size. A state-of-the-art 3D focus variation measurement instrument was used for characterizing the flash on moulded parts. Four injection moulding process parameters were tested using a Design of Experiment (DoE) approach in both real experiments and simulations in order to validate the numerical outputs with respect to process variations. The results showed that flash size was generally overestimated by simulations. However, both real parts measurements and numerical results agreed on the signs and magnitudes of the effects of the investigated process parameters, demonstrating that simulations are an useful tool for process/product optimization.

Published
2018

70. Geometrical shape assessment of additively manufactured features by direct light processing vat polymerization method

Author

Billington, D., Leach, R. K., Phillips, D., Riemer, O., Savio, E., Péreza, Lucia C. Díaz, Davoudinejad, Ali, Quagliotti, Danilo, Pedersen, David Bue, Garcíaa, José A. Albajez, Yagüe-Fabraa, José A., Tosello, Guido, Billington, D., Leach, R. K., Phillips, D., Riemer, O., Savio, E., Péreza, Lucia C. Díaz, Davoudinejad, Ali, Quagliotti, Danilo, Pedersen, David Bue, Garcíaa, José A. Albajez, Yagüe-Fabraa, José A., and Tosello, Guido

Abstract

The importance of Additive Manufacturing (AM) in the field of micro manufacturing is increasing. Vat Polymerization Methods are one of the lead AM technologies to produce polymer micro parts. In the Technical University of Denmark (DTU), a vat photopolymerization AM machine able to print features in a micro scale was developed, build and validated. The work here presented analyses the capability of the machine in terms of geometry, when printing features of different sizes and geometries. For this study, two test parts have been designed, a circular stepped pyramid and a square stepped pyramid, both having micro size steps at the top of the pyramids. Five batches of each test part have been printed to evaluate the variability of the results in a single and in various prints.

Published
2018

71. Numerical Study of the Impact of Shear Thinning Behaviour on the Strand Deposition Flow in the Extrusion-Based Additive Manufacturing

Author

Billington, D., Leach, R. K., Phillips, D., Riemer, O., Savio, E., Serdeczny, Marcin P., Comminal, Raphaël, Pedersen, David B., Spangenberg, Jon, Billington, D., Leach, R. K., Phillips, D., Riemer, O., Savio, E., Serdeczny, Marcin P., Comminal, Raphaël, Pedersen, David B., and Spangenberg, Jon

Abstract

This paper investigates the influence of shear-rate dependent viscosity on the strand deposition flow during Extrusion-Based Additive Manufacturing. Extrusion-Based Additive Manufacturing, also known as Fused Deposition Modeling (FDM), is a manufacturing method in which material is joined layer by layer into a 3D object. A solid filament is heated above the melting point and extruded through a nozzle to form a strand. The process is modelled within the paradigm of Computational Fluid Dynamics as an isothermal Generalized Newtonian fluid flow. The power law is used as the constitutive relation between the shear-rate and the viscosity. A sensitivity study of the model’s input parameters (power-law index and consistency index) is made. The simulations are performed varying two process parameters: the vertical distance between the substrate and nozzle exit as well as the relative horizontal velocity between the substrate and nozzle. The model is used to investigate the cross-sectional shape of the strand after the deposition and the force exerted on the substrate by the material extruded from the nozzle (the printing force). Under the tested conditions, we find a neglible change in the cross-sectional shape and the printing force behaviour when varying the power-law index and the consistency index. Thus, it is concluded that the Newtonian fluid model provides a sufficient approximation to simulate the deposition flow under the given assumptions.

Published
2018

74. The Role of Trauma-Related Injustice in Pathways to Posttraumatic Stress Symptoms Among Conjugal Couples: A Multilevel, Dyadic Analysis in Postconflict Timor-Leste

Author

Tay, AK, Rees, SJ, Tam, N, Savio, E, Costa, ZMD, Silove, D, Tay, AK, Rees, SJ, Tam, N, Savio, E, Costa, ZMD, and Silove, D

Abstract

It is widely acknowledged that the survivor’s psychological response to the traumas of mass conflict can affect adversely other family members. Yet, the focus of past epidemiological studies in the field has been confined to the individual survivor’s posttraumatic stress symptom (PTSS) response. We report the first study of its kind in a postconflict country, in which we examine the effects of trauma exposure in one member of conjugal couples on the PTSS of the other. The study involved 677 conjugal couples drawn from a community survey (n = 1,354) in postconflict Timor-Leste. We used culturally adapted and psychometrically tested measures of traumatic events (TEs), preoccupations with injustice, explosive anger, family conflict, and PTSS. A multilevel actor–partner interdependence model (ML-APIM) demonstrated individual pathways involving exposure to murder and atrocities, preoccupations with injustice, explosive anger, and family conflict, leading to PTSS in both men and women when examined separately, with minor variations in paths by gender. Preoccupations with injustice in male survivors contributed to PTSS in the female partner, but not vice versa. Women may have a gender-specific propensity to identify with the male partner’s preoccupations with injustice following exposure to murder and atrocities. Our findings offer novel clues to the possible factors contributing to the higher rates of PTSS among women.

Published
2017

75. Six-year longitudinal study of pathways leading to explosive anger involving the traumas of recurrent conflict and the cumulative sense of injustice in Timor-Leste

Author

Silove, D, Mohsin, M, Tay, AK, Steel, Z, Tam, N, Savio, E, Da Costa, ZM, Rees, S, Silove, D, Mohsin, M, Tay, AK, Steel, Z, Tam, N, Savio, E, Da Costa, ZM, and Rees, S

Abstract

Purpose: Cumulative evidence suggests that explosive anger may be a common reaction among survivors of mass conflict. However, little is known about the course of explosive anger in the years following mass conflict, or the psychosocial factors that influence the trajectory of that reaction pattern. We examined these issues in a 6-year longitudinal study (2004–2010) conducted among adult residents of a rural and an urban village in Timor-Leste (n = 1022). Methods: We derived a brief, context-specific index of explosive anger using qualitative methods. Widely used measures of post-traumatic stress disorder (PTSD) and severe psychological distress were calibrated to the Timor context. We developed an index of the cumulative sense of injustice related to consecutive historical periods associated with conflict in Timor-Leste. We applied partial structural equation modeling (SEM) to examine pathways from baseline explosive anger, socio-demographic factors, recurrent trauma, mental health indices (PTSD, severe psychological distress) and the sense of injustice, to explosive anger. Results: Half of the sample with explosive anger at baseline continued to report that reaction pattern after 6 years; and a third of those who did not report explosive anger at baseline developed the response by follow-up. A symmetrical pattern of younger age, female gender and the trauma count for the preceding historical period predicted explosive anger at each assessment point. The sense of injustice was related to explosive anger at follow-up. Explosive anger was associated with impairment in functioning and conflict with the intimate partner and wider family. Conclusions: Sampling constraints caution against generalizing our findings to other populations. Nevertheless, our data suggest that explosive anger may persist for a prolonged period of time following mass conflict and that the response pattern is initiated and maintained by recurrent trauma exposure associated with a sense of injust

Published
2017

76. Identifying a combined construct of grief and explosive anger as a response to injustice amongst survivors of mass conflict: A latent class analysis of data from Timor-Leste

Author

Rees, SJ, Tay, AK, Savio, E, Costa, ZMD, Silove, D, Rees, SJ, Tay, AK, Savio, E, Costa, ZMD, and Silove, D

Abstract

Previous studies have identified high rates of explosive anger amongst post-conflict populations including Timor-Leste. We sought to test whether explosive anger was integrally associated with symptoms of grief amongst the Timorese, a society that has experienced extensive conflict-related losses. In 2010 and 2011 we recruited adults (n = 2964), 18-years and older, living in an urban and a rural village in Timor-Leste. We applied latent class analysis to identify subpopulations based on symptoms of explosive anger and grief. The best fitting model comprised three classes: grief (24%), grief-Anger (25%), and a low symptom group (51%). There were more women and urban dwellers in the grief and grief-Anger classes compared to the reference class. Persons in the grief and grief-Anger classes experienced higher rates of witnessing murder and atrocities and traumatic losses, ongoing poverty, and preoccupations with injustice for the two historical periods of conflict (the Indonesian occupation and the later internal conflict). Compared to the reference class, only the grief-Anger class reported greater exposure to extreme deprivations during the conflict, ongoing family conflict, and preoccupations with injustice for contemporary times; and compared to the grief class, greater exposure to traumatic losses, poverty, family conflict and preoccupations with injustice for both the internal conflict and contemporary times. A substantial number of adults in this postconflict country experienced a combined constellation of grief and explosive anger associated with extensive traumatic losses, deprivations, and preoccupations with injustice. Importantly, grief-Anger may be linked to family conflict in this post-conflict environment.

Published
2017

78. Circulating microRNAs in Sera Correlate with Soluble Biomarkers of Immune Activation but Do Not Predict Mortality in ART Treated Individuals with HIV-1 Infection: A Case Control Study

Author

Murray, D. D., Suzuki, K., Law, M., Trebicka, J., Neuhaus, J., Wentworth, D., Johnson, M., Vjecha, M. J., Kelleher, A. D., Emery, S., Aagaard, B., Aragon, E., Arnaiz, J., Borup, L., Clotet, B., Dragsted, U., Fau, A., Gey, D., Grarup, J., Hengge, U., Herrero, P., Jansson, P., Jensen, B., Jensen, K., Juncher, H., Lopez, P., Lundgren, J. D., Matthews, C., Mollerup, D., Pearson, M., Phillips, A., Reilev, S., Tillmann, K., Varea, S., Angus, B., Babiker, A., Cordwell, B., Darbyshire, J., Dodds, W., Fleck, S., Horton, J., Hudson, F., Moraes, Y., Pacciarini, F., Palfreeman, A., Paton, N., Smith, N., Van Hooff, F., Bebchuk, J., Collins, G., Denning, E., Duchene, A., Fosdick, L., Harrison, M., Herman-Lamin, K., Krum, E., Larson, G., Neaton, J., Nelson, R., Quan, K., Quan, S., Schultz, T., Thompson, G., Wyman, N., Carey, C., Chan, F., Cooper, D., Courtney-Rodgers, D., Drummond, F., Harrod, M., Jacoby, S., Kearney, L., Lin, E., Pett, S., Robson, R., Seneviratne, N., Stewart, M., Watts, E., Finley, E., Gordin, F., Sanchez, A., Standridge, B., Belloso, W., Davey, R., Duprez, D., Gatell, J., Hoy, J., Lifson, A., Pederson, C., Perez, G., Price, R., Prineas, R., Rhame, F., Sampson, J., Worley, J., Modlin, J., Beral, V., Chaisson, R., Fleming, T., Hill, C., Kim, K., Murray, B., Pick, B., Seligmann, M., Weller, I., Cahill, K., Fox, L., Luzar, M., Martinez, A., Mcnay, L., Pierson, J., Tierney, J., Vogel, S., Costas, V., Eckstrand, J., Brown, S., Abusamra, L., Angel, E., Aquilia, S., Benetucci, J., Bittar, V., Bogdanowicz, E., Cahn, P., Casiro, A., Contarelli, J., Corral, J., Daciuk, L., David, D., Dobrzanski, W., Duran, A., Ebenrstejin, J., Ferrari, I., Fridman, D., Galache, V., Guaragna, G., Ivalo, S., Krolewiecki, A., Lanusse, I., Laplume, H., Lasala, M., Lattes, R., Lazovski, J., Lopardo, G., Losso, M., Lourtau, L., Lupo, S., Maranzana, A., Marson, C., Massera, L., Moscatello, G., Olivia, S., Otegui, I., Palacios, L., Parlante, A., Salomon, H., Sanchez, M., Somenzini, C., Suarez, C., Tocci, M., Toibaro, J., Zala, C., Agrawal, S., Ambrose, P., Anderson, C., Anderson, J., Baker, D., Beileiter, K., Blavius, K., Bloch, M., Boyle, M., Bradford, D., Britton, P., Brown, P., Busic, T., Cain, A., Carrall, L., Carson, S., Chenoweth, I., Chuah, J., Clark, F., Clemons, J., Clezy, K., Cortissos, P., Cunningham, N., Curry, M., Daly, L., D'Arcy-Evans, C., Del Rosario, R., Dinning, S., Dobson, P., Donohue, W., Doong, N., Downs, C., Edwards, E., Edwards, S., Egan, C., Ferguson, W., Finlayson, R., Forsdyke, C., Foy, L., Franic, T., Frater, A., French, M., Gleeson, D., Gold, J., Habel, P., Haig, K., Hardy, S., Holland, R., Hudson, J., Hutchison, R., Hyland, N., James, R., Johnston, C., Kelly, M., King, M., Kunkel, K., Lau, H., Leamy, J., Lester, D., Leung, J., Lohmeyer, A., Lowe, K., Macrae, K., Magness, C., Martinez, O., Maruszak, H., Medland, N., Miller, S., Murray, J., Negus, P., Newman, R., Ngieng, M., Nowlan, C., Oddy, J., Orford, N., Orth, D., Patching, J., Plummer, M., Price, S., Primrose, R., Prone, I., Ree, H., Remington, C., Richardson, R., Robinson, S., Rogers, G., Roney, J., Roth, N., Russell, D., Ryan, S., Sarangapany, J., Schmidt, T., Schneider, K., Shields, C., Silberberg, C., Shaw, D., Skett, J., Smith, D., Soo, T. M., Sowden, D., Street, A., Tee, B. K., Thomson, J., Topaz, S., Vale, R., Villella, C., Walker, A., Watson, A., Wendt, N., Williams, L., Youds, D., Aichelburg, A., Cichon, P., Gemeinhart, B., Rieger, A., Schmied, B., Touzeau-Romer, V., Vetter, N., Colebunders, R., Clumeck, N., Deroo, A., Kabeya, K., O'Doherty, E., De Wit, S., De Salles Amorim, C., Basso, C., Flint, S., Kallas, E., Levi, G., Lewi, D., Pereira, L., Da Silva, M., Souza, T., Toscano, A., Angel, J., Arsenault, M., Bast, M., Beckthold, B., Bouchard, P., Chabot, I., Clarke, R., Cohen, J., Cote, P., Ellis, M., Gagne, C., Gill, J., Houde, M., Johnston, B., Jubinville, N., Kato, C., Lamoureux, N., Latendre-Paquette, J., Lindemulder, A., Mcneil, A., Mcfarland, N., Montaner, J., Morrisseau, C., O'Neill, R., Page, G., Piche, A., Pongracz, B., Preziosi, H., Puri, L., Rachlis, A., Ralph, E., Raymond, I., Rouleau, D., Routy, J. P., Sandre, R., Seddon, T., Shafran, S., Sikora, C., Smaill, F., Stromberg, D., Trottier, S., Walmsley, S., Weiss, K., Williams, K., Zarowny, D., Baadegaard, B., Andersen, A. B., Boedker, K., Collins, P., Gerstoft, J., Jensen, L., Moller, H., Andersen, P. L., Loftheim, I., Mathiesen, L., Nielsen, H., Obel, N., Pedersen, C., Petersen, D., Jensen, L. P., Black, F. T., Aboulker, J. P., Aouba, A., Bensalem, M., Berthe, H., Blanc, C., Bornarel, D., Bouchaud, O., Boue, F., Bouvet, E., Brancon, C., Breaud, S., Brosseau, D., Brunet, A., Capitant, C., Ceppi, C., Chakvetadze, C., Cheneau, C., Chennebault, J. M., De Truchis, P., Delavalle, A. M., Delfraissy, J. F., Dellamonica, P., Dumont, C., Edeb, N., Fabre, G., Ferrando, S., Foltzer, A., Foubert, V., Gastaut, J. A., Gerbe, J., Girard, P. M., Goujard, C., Hoen, B., Honore, P., Hue, H., Hynh, T., Jung, C., Kahi, S., Katlama, C., Lang, J. M., Le Baut, V., Lefebvre, B., Leturque, N., Levy, Y., Loison, J., Maddi, G., Maignan, A., Majerholc, C., De Boever, C., Meynard, J. L., Michelet, C., Michon, C., Mole, M., Netzer, E., Pialoux, G., Poizot-Martin, I., Raffi, F., Ratajczak, M., Ravaux, I., Reynes, J., Salmon-Ceron, D., Sebire, M., Simon, A., Tegna, L., Tisne-Dessus, D., Tramoni, C., Viard, J. P., Vidal, M., Viet-Peaucelle, C., Weiss, L., Zeng, A., Zucman, D., Adam, A., Arasteh, K., Behrens, G., Bergmann, F., Bickel, M., Bittner, D., Bogner, J., Brockmeyer, N., Darrelmann, N., Deja, M., Doerler, M., Esser, S., Faetkenheuer, G., Fenske, S., Gajetzki, S., Goebel, F., Gorriahn, D., Harrer, E., Harrer, T., Hartl, H., Hartmann, M., Heesch, S., Jakob, W., Jager, H., Klinker, H., Kremer, G., Ludwig, C., Mantzsch, K., Mauss, S., Meurer, A., Niedermeier, A., Pittack, N., Plettenberg, A., Potthoff, A., Probst, M., Rittweger, M., Rockstroh, J., Ross, B., Rotty, J., Rund, E., Ruzicka, T., Schmidt, R., Schmutz, G., Schnaitmann, E., Schuster, D., Sehr, T., Spaeth, B., Staszewski, S., Stellbrink, H. J., Stephan, C., Stockey, T., Stoehr, A., Trein, A., Vaeth, T., Vogel, M., Wasmuth, J., Wengenroth, C., Winzer, R., Wolf, E., Mulcahy, F., Reidy, D., Cohen, Y., Drora, G., Eliezer, I., Godo, O., Kedem, E., Magen, E., Mamorsky, M., Pollack, S., Sthoeger, Z., Vered, H., Yust, I., Aiuti, F., Bechi, M., Bergamasco, A., Bertelli, D., Bruno, R., Butini, L., Cagliuso, M., Carosi, G., Casari, S., Chrysoula, V., Cologni, G., Conti, V., Costantini, A., Corpolongo, A., D'Offizi, G., Gaiottino, F., Di Pietro, M., Esposito, R., Filice, G., Francesco, M., Gianelli, E., Graziella, C., Magenta, L., Martellotta, F., Maserati, R., Mazzotta, F., Murdaca, G., Nardini, G., Nozza, S., Puppo, F., Pogliaghi, M., Ripamonti, D., Ronchetti, C., Rusconi, S., Rusconi, V., Sacchi, P., Silvia, N., Suter, F., Tambussi, G., Uglietti, A., Vechi, M., Vergani, B., Vichi, F., Vitiello, P., Iwamoto, A., Kikuchi, Y., Miyazaki, N., Mori, M., Nakamura, T., Odawara, T., Oka, S., Shirasaka, T., Tabata, M., Takano, M., Ueta, C., Watanabe, D., Yamamoto, Y., Erradey, I., Himmich, H., El Filali, K. M., Blok, W., Van Boxtel, R., Doevelaar, K. B. H., Van Eeden, A., Grijsen, M., Groot, M., Juttmann, J., Kuipers, M., Ligthart, S., Van Der Meulen, P., Lange, J., Langebeek, N., Reiss, P., Richter, C., Schoemaker, M., Schrijnders-Gudde, L., Septer-Bijleveld, E., Sprenger, H., Vermeulen, J., Ten Kate, R., Van De Ven, B., Bruun, J., Kvale, D., Maeland, A., Bakowska, E., Beniowski, M., Boron-Kaczmarska, A., Gasiorowski, J., Horban, A., Inglot, M., Knysz, B., Mularska, E., Parczewski, M., Pynka, M., Rymer, W., Szymczak, A., Aldir, M., Antunes, F., Baptista, C., Da Conceicao Vera, J., Doroana, M., Mansinho, K., Dos Santos, C. R. A., Valadas, E., Vaz Pinto, I., Chia, E., Foo, E., Karim, F., Lim, P. L., Panchalingam, A., Quek, A., Alcazar-Caballero, R., Arribas, J., Arrizabalaga, J., De Barron, X., Blanco, F., Bouza, E., Bravo, I., Calvo, S., Carbonero, L., Carpena, I., Castro, M., Cortes, L., Del Toro, M., Domingo, P., Elias, M., Espinosa, J., Estrada, V., Fernandez-Cruz, E., Fernandez, P., Freud, H., Fuster, M., Garcia, A., Garcia, G., Garrido, R., Gijon, P., Gonzalez-Garcia, J., Gil, I., Gonzalez, A., Gonzalez-Lahoz, J., Grosso, P. L., Gutierrez, M., Guzman, E., Iribarren, J., Jimenez, M., Jou, A., Juega, J., Lopez, J., Lozano, F., Martin-Carbonero, L., Mata, R., Mateo, G., Menasalvas, A., Mirelles, C., De Miguel Prieto, J., Montes, M., Moreno, A., Moreno, J., Moreno, V., Munoz, R., Ocampo, A., Ortega, E., Ortiz, L., Padilla, B., Parras, A., Paster, A., Pedreira, J., Pena, J., Perea, R., Portas, B., Puig, J., Pulido, F., Rebollar, M., De Rivera, J., Roca, V., Rodriguez-Arrondo, F., Rubio, R., Santos, J., Sanz, J., Sebastian, G., Segovia, M., Soriano, V., Tamargo, L., Viciana, P., Von Wichmann, M., Bratt, G., Hollander, A., Olov Pehrson, P., Petz, I., Sandstrom, E., Sonnerborg, A., Bernasconi, E., Gurtner, V., Ampunpong, U., Auchieng, C., Bowonwatanuwong, C., Chanchai, P., Chetchotisakd, P., Chuenyan, T., Duncombe, C., Horsakulthai, M., Kantipong, P., Laohajinda, K., Phanuphak, P., Pongsurachet, V., Pradapmook, S., Ruxruntham, K., Seekaew, S., Sonjai, A., Suwanagool, S., Techasathit, W., Ubolyam, S., Wankoon, J., Alexander, I., Dockrell, D., Easterbrook, P., Edwards, B., Evans, E., Fisher, M., Fox, R., Gazzard, B., Gilleran, G., Hand, J., Heald, L., Higgs, C., Jebakumar, S., Jendrulek, I., Johnson, S., Kinghorn, G., Kuldanek, K., Leen, C., Maw, R., Mckernan, S., Mclean, L., Morris, S., Murphy, M., O'Farrell, S., Ong, E., Peters, B., Stroud, C., Wansbrough-Jones, M., Weber, J., White, D., Williams, I., Wiselka, M., Yee, T., Adams, S., Allegra, D., Andrews, L., Aneja, B., Anstead, G., Arduino, R., Artz, R., Bailowitz, J., Banks, S., Baxter, J., Baum, J., Benator, D., Black, D., Boh, D., Bonam, T., Brito, M., Brockelman, J., Bruzzese, V., Burnside, A., Cafaro, V., Casey, K., Cason, L., Childress, G., Clark, C., Clifford, D., Climo, M., Cohn, D., Couey, P., Cuervo, H., Deeks, S., Dennis, M., Diaz-Linares, M., Dickerson, D., Diez, M., Di Puppo, J., Dodson, P., Dupre, D., Elion, R., Elliott, K., El-Sadr, W., Estes, M., Fabre, J., Farrough, M., Flamm, J., Follansbee, S., Foster, C., Frank, C., Franz, J., Frechette, G., Freidland, G., Frische, J., Fuentes, L., Funk, C., Geisler, C., Genther, K., Giles, M., Goetz, M., Gonzalez, M., Graeber, C., Graziano, F., Grice, D., Hahn, B., Hamilton, C., Hassler, S., Henson, A., Hopper, S., John, M., Johnson, L., Johnson, R., Jones, R., Kahn, J., Klimas, N., Kolber, M., Koletar, S., Labriola, A., Larsen, R., Lasseter, F., Lederman, M., Ling, T., Lusch, T., Macarthur, R., Machado, C., Makohon, L., Mandelke, J., Mannheimer, S., Markowitz, N., Martinez, M., Martinez, N., Mass, M., Masur, H., Mcgregor, D., Mcintyre, D., Mckee, J., Mcmullen, D., Mettinger, M., Middleton, S., Mieras, J., Mildvan, D., Miller, P., Miller, T., Mitchell, V., Mitsuyasu, R., Moanna, A., Mogridge, C., Moran, F., Murphy, R., Mushatt, D., Nahass, R., Nixon, D., O'Brien, S., Ojeda, J., Okhuysen, P., Olson, M., Osterberger, J., Owen, W., Pablovich, S., Patel, S., Pierone, G., Poblete, R., Potter, A., Preston, E., Rappoport, C., Regevik, N., Reyelt, M., Riney, L., Rodriguez-Barradas, M., Rodriguez, J., Roland, R., Rosmarin-DeStefano, C., Rossen, W., Rouff, J., Saag, M., Santiago, S., Sarria, J., Wirtz, S., Schmidt, U., Scott, C., Sheridan, A., Shin, A., Shrader, S., Simon, G., Slowinski, D., Smith, K., Spotkov, J., Sprague, C., States, D., Suh, C., Sullivan, J., Summers, K., Sweeton, B., Tan, V., Tanner, T., Tedaldi, E., Temesgen, Z., Thomas, D., Thompson, M., Tobin, C., Toro, N., Towner, W., Upton, K., Uy, J., Valenti, S., Van Der Horst, C., Vita, J., Voell, J., Walker, J., Walton, T., Wason, K., Watson, V., Wellons, A., Weise, J., White, M., Whitman, T., Williams, B., Williams, N., Windham, J., Witt, M., Workowski, K., Wortmann, G., Wright, T., Zelasky, C., Zwickl, B., Dietz, D., Chesson, C., Vjecha, M., Schmetter, B., Grue, L., Willoughby, M., Demers, A., Dragsted, U. B., Jensen, K. B., Jansson, P. O., Jensen, B. G., Benfield, T. L., Darbyshire, J. H., Babiker, G., Fleck, S. L., Collaco-Moraes, Y., Wyzydrag, L., Drummond, F. M., Connor, S. A., Satchell, C. S., Gunn, S., Delfino, M. A., Merlin, K., Mcginley, C., Neaton, J. D., Bartsch, G., George, M., Grund, B., Hogan, C., Miller, C., Roediger, M. P., Thackeray, L., Campbell, C., Lahart, C., Perlman, D., Rein, M., Dersimonian, R., Brody, B. A., Daar, E. S., Dubler, N. N., Fleming, T. R., Freeman, D. J., Kahn, J. P., Kim, K. M., Medoff, G., Modlin, J. F., Moellering, R., Murray, B. E., Robb, M. L., Scharfstein, D. O., Sugarman, J., Tsiatis, A., Tuazon, C., Zoloth, L., Klingman, K., Lehrman, S., Belloso, W. H., Losso, M. H., Benetucci, J. A., Bogdanowicz, E. P., Cahn, P. E., Casiro, A. D., Cassetti, I., Contarelli, J. M., Corral, J. A., Crinejo, A., David, D. O., Ishida, M. T., Laplume, H. E., Lasala, M. B., Lupo, S. H., Masciottra, F., Michaan, M., Ruggieri, L., Salazar, E., Hoy, J. F., Rogers, G. D., Allworth, A. M., Anderson, J. S. C., Armishaw, J., Barnes, K., Carr, A., Chiam, A., Chuah, J. C. P., Curry, M. C., Dever, R. L., Donohue, W. A., Doong, N. C., Dwyer, D. E., Dyer, J., Eu, B., Ferguson, V. W., French, M. A. H., Garsia, R. J., Hudson, J. H., Jeganathan, S., Konecny, P., Mccormack, C. L., Mcmurchie, M., Moore, R. J., Moussa, M. B., Piper, M., Read, T., Roney, J. J., Shaw, D. R., Silvers, J., Smith, D. J., Street, A. C., Vale, R. J., Wendt, N. A., Wood, H., Youds, D. W., Zillman, J., Tozeau, V., Dewit, S., De Roo, A., Leonard, P., Lynen, L., Moutschen, M., Pereira, L. C., Souza, T. N. L., Schechter, M., Zajdenverg, R., Almeida, M. M. T. B., Araujo, F., Bahia, F., Brites, C., Caseiro, M. M., Casseb, J., Etzel, A., Falco, G. G., Filho, E. C. J., Flint, S. R., Gonzales, R., Madruga, J. V. R., Passos, L. N., Reuter, T., Sidi, L. C., Toscano, A. L. C., Cherban, E., Conway, B., Dufour, C., Foster, A., Haase, D., Haldane, H., Klein, M., Lessard, B., Martel, A., Martel, C., Paradis, E., Schlech, W., Schmidt, S., Thompson, B., Vezina, S., Reyes, M. J. W., Northland, R., Ostergaard, L., Hergens, L., Loftheim, I. R., Raukas, M., Zilmer, K., Justinen, J., Ristola, M., Landman, R., Abel, S., Abgrall, S., Amat, K., Auperin, L., Barruet, R., Benalycherif, A., Benammar, N., Bentata, M., Besnier, J. M., Blanc, M., Cabie, A., Chavannet, P., Dargere, S., De La Tribonniere, X., Debord, T., Decaux, N., Delgado, J., Dupon, M., Durant, J., Frixon-Marin, V., Genet, C., Gerard, L., Gilquin, J., Jeantils, V., Kouadio, H., Leclercq, P., Lelievre, J. D., Michon, C. P., Nau, P., Pacanowski, J., Piketty, C., Salmon, D., Schmit, J. L., Serini, M. A., Tassi, S., Touam, F., Verdon, R., Weinbreck, P., Yazdanpanah, Y., Yeni, P., Fatkenheuer, G., Bitsch, S., Bogner, J. R., Goebel, F. D., Lehmann, C., Lennemann, T., Wasmuth, J. C., Wiedemeyer, K., Hatzakis, A., Touloumi, G., Antoniadou, A., Daikos, G. L., Dimitrakaki, A., Gargalianos-Kakolyris, P., Giannaris, M., Karafoulidou, A., Katsambas, A., Katsarou, O., Kontos, A. N., Kordossis, T., Lazanas, M. K., Panagopoulos, P., Panos, G., Paparizos, V., Papastamopoulos, V., Petrikkos, G., Sambatakou, H., Skoutelis, A., Tsogas, N., Xylomenos, G., Bergin, C. J., Mooka, B., Mamorksy, M. G., Agmon-Levin, N., Karplus, R., Maayan, S., Shahar, E., Turner, D., Abeli, C., Biglino, A., Bonora, S., De Gioanni, M., Di Perri, G., Montroni, M., Quirino, T., Raise, E., Honda, M., Ishisaka, M., Caplinskas, S., Uzdaviniene, V., Schmit, J. C., Staub, T., Mills, G. D., Blackmore, T., Masters, J. A., Morgan, J., Pithie, A., Brunn, J., Ormassen, V., La Rosa, A., Guerra, O., Espichan, M., Gutierrez, L., Mendo, F., Salazar, R., Knytz, B., Kwiatkowski, J., Castro, R. S., Horta, A., Miranda, A. C., Pinto, I. V., Vera, J., Rakhmanova, A., Vinogradova, E., Yakovlev, A., Zakharova, N., Wood, R., Orrel, C., Arnaiz, J. A., Carrillo, R., Dalmau, D., Jordano, Q., Knobel, H., Larrousse, M., Moreno, J. S., Oretaga, E., Pena, J. N., Hirschel, B., Spycher, R., Battegay, M., Bottone, S., Cavassini, M., Christen, A., Furrer, H. J., Gayet-Ageron, A., Genne, D., Hochstrasser, S., Moens, C., Muller, N., Nuesch, R., Ruxrungtham, K., Pumpradit, W., Dangthongdee, S., Kiertiburanakul, S., Klinbuayaem, V., Mootsikapun, P., Nonenoy, S., Piyavong, B., Prasithsirikul, W., Raksakulkarn, P., Gazzard, B. G., Ainsworth, J. G., Angus, B. J., Barber, T. J., Brook, M. G., Care, C. D., Chadwick, D. R., Chikohora, M., Churchill, D. R., Cornforth, D., Dockrell, D. H., Easterbrook, P. J., Fox, P. A., Gomez, P. A., Gompels, M. M., Harris, G. M., Herman, S., Jackson, A. G. A., Jebakumar, S. P. R., Kinghorn, G. R., Kuldanek, K. A., Larbalestier, N., Lumsden, M., Maher, T., Mantell, J., Muromba, L., Orkin, C. M., Peters, S., Peto, T. E. A., Portsmouth, S. D., Rajamanoharan, S., Ronan, Schwenk, A., Slinn, M. A., Stroud, C. J., Thomas, R. C., Wansbrough-Jones, M. H., Whiles, H. J., White, D. J., Williams, E., Williams, G., Youle, M., Abrams, D. I., Acosta, E. A., Adamski, A., Antoniskis, D., Aragon, D. R., Barnett, B. J., Baroni, C., Barron, M., Baxter, J. D., Beers, D., Beilke, M., Bemenderfer, Bernard, A., Besch, C. L., Bessesen, M. T., Bethel, J. T., Blue, S., Blum, J. D., Boarden, S., Bolan, R. K., Borgman, J. B., Brar, I., Braxton, B. K., Bredeek, U. F., Brennan, R., Britt, D. E., Bulgin-Coleman, D., Bullock, E., Campbell, B., Caras, S., Carroll, J., Casey, K. K., Chiang, F., Cindrich, R. B., Cohen, C., Coley, J., Condoluci, D. V., Contreras, R., Corser, J., Cozzolino, J., Crane, L. R., Daley, L., Dandridge, D., D'Antuono, V., Darcourt Rizo Patron, J. G., Dehovitz, J. A., Dejesus, E., Desjardin, J., Dietrich, C., Dolce, A., Erickson, D., Faber, L. L., Falbo, J., Farrough, M. J., Farthing, C. F., Ferrell-Gonzalez, P., Flynn, H., Frank, M., Freeman, K. F., French, N., Friedland, G., Fujita, N., Gahagan, L., Gilson, I., Goetz, M. B., Goodwin, E., Guity, C. K., Gulick, P., Gunderson, E. R., Hale, C. M., Hannah, K., Henderson, H., Hennessey, K., Henry, W. K., Higgins, T., Hodder, S. L., Horowitz, H. W., Howe-Pittman, M., Hubbard, J., Hudson, R., Hunter, H., Hutelmyer, C., Insignares, M. T., Jackson, L., Jenny, L., Johnson, D. L., Johnson, G., Johnson, J., Kaatz, J., Kaczmarski, J., Kagan, S., Kantor, C., Kempner, T., Kieckhaus, K., Kimmel, N., Klaus, B. M., Koeppe, J. R., Koirala, J., Kopka, J., Kostman, J. R., Kozal, M. J., Kumar, A., Lampiris, H., Lamprecht, C., Lattanzi, K. M., Lee, J., Leggett, J., Long, C., Loquere, A., Loveless, K., Lucasti, C. J., Luskin-Hawk, R., Macveigh, M., Makohon, L. H., Markowitz, N. P., Marks, C., Martorell, C., Mcfeaters, E., Mcgee, B., Mcintyre, D. M., Mcmanus, E., Melecio, L. G., Melton, D., Mercado, S., Merrifield, E., Mieras, J. A., Mogyoros, M., Moran, F. M., Murphy, K., Mutic, S., Nadeem, I., Nadler, J. P., Ognjan, A., O'Hearn, M., O'Keefe, K., Okhuysen, P. C., Oldfield, E., Olson, D., Orenstein, R., Ortiz, R., Parpart, F., Pastore-Lange, V., Paul, S., Pavlatos, A., Pearce, D. D., Pelz, R., Peterson, S., Pitrak, D., Powers, S. L., Pujet, H. C., Raaum, J. W., Ravishankar, J., Reeder, J., Reilly, N. A., Reyelt, C., Riddell, J., Rimland, D., Robinson, M. L., Rodriguez, A. E., Rodriguez Derouen, V., Rosmarin, C., Rossen, W. L., Rouff, J. R., Sands, M., Savini, C., Schrader, S., Schulte, M. M., Scott, R., Seedhom, H., Sension, M., Sheblehall, A., Shuter, J., Slater, L. N., Slotten, R., Smith, M., Snap, S., States, D. M., Stringer, G., Summers, K. K., Swanson, K., Sweeton, I. B., Szabo, S., Tedaldi, E. M., Telzak, E. E., Thompson, M. A., Thompson, S., Bong, C. T. H., Vaccaro, A., Vasco, L. M., Vecino, I., Verlinghieri, G. K., Visnegarwala, F., Wade, H., Weis, S. E., Weise, J. A., Weissman, S., Wilkin, M., Witter, J. H., Wojtusic, L., Wright, T. J., Yeh, V., Young, B., Zeana, C., Zeh, J., Savio, E., Vacarezza, M., and Pacheco, Antonio Guilherme

Subjects
Adult, CD4-Positive T-Lymphocytes, Male, General Science & Technology, Anti-HIV Agents, T cell, lcsh:Medicine, Antiretroviral Therapy, HIV Infections, Biology, Essential hypertension, Logistic regression, Malignancy, Acquired immunodeficiency syndrome (AIDS), Clinical Research, Antiretroviral Therapy, Highly Active, microRNA, medicine, Genetics, 2.1 Biological and endogenous factors, Humans, Highly Active, Aetiology, lcsh:Science, Genetic Association Studies, Multidisciplinary, lcsh:R, Case-control study, Middle Aged, medicine.disease, 3. Good health, Circulating MicroRNA, MicroRNAs, medicine.anatomical_structure, Infectious Diseases, Good Health and Well Being, INSIGHT ESPRIT and SMART Study Groups, Immunology, HIV-1, HIV/AIDS, lcsh:Q, Female, Infection, Biomarkers, Biotechnology, Research Article
Abstract

Introduction The use of anti-retroviral therapy (ART) has dramatically reduced HIV-1 associated morbidity and mortality. However, HIV-1 infected individuals have increased rates of morbidity and mortality compared to the non-HIV-1 infected population and this appears to be related to end-organ diseases collectively referred to as Serious Non-AIDS Events (SNAEs). Circulating miRNAs are reported as promising biomarkers for a number of human disease conditions including those that constitute SNAEs. Our study sought to investigate the potential of selected miRNAs in predicting mortality in HIV-1 infected ART treated individuals. Materials and Methods A set of miRNAs was chosen based on published associations with human disease conditions that constitute SNAEs. This case: control study compared 126 cases (individuals who died whilst on therapy), and 247 matched controls (individuals who remained alive). Cases and controls were ART treated participants of two pivotal HIV-1 trials. The relative abundance of each miRNA in serum was measured, by RTqPCR. Associations with mortality (all-cause, cardiovascular and malignancy) were assessed by logistic regression analysis. Correlations between miRNAs and CD4+ T cell count, hs-CRP, IL-6 and D-dimer were also assessed. Results None of the selected miRNAs was associated with all-cause, cardiovascular or malignancy mortality. The levels of three miRNAs (miRs -21, -122 and -200a) correlated with IL-6 while miR-21 also correlated with D-dimer. Additionally, the abundance of miRs -31, -150 and -223, correlated with baseline CD4+ T cell count while the same three miRNAs plus miR-145 correlated with nadir CD4+ T cell count. Discussion No associations with mortality were found with any circulating miRNA studied. These results cast doubt onto the effectiveness of circulating miRNA as early predictors of mortality or the major underlying diseases that contribute to mortality in participants treated for HIV-1 infection.

Published
2015

79. Development and validation of a risk score for chronic kidney disease in HIV infection using prospective cohort data from the D:A:D study

Author

Mocroft, Amanda, Lundgren, Jens D., Ross, Michael, Law, Matthew, Reiss, Peter, Kirk, Ole, Smith, Colette, Wentworth, Deborah, Neuhaus, Jacqueline, Fux, Christoph A., Moranne, Olivier, Morlat, Phillipe, Johnson, Margaret A., Ryom, Lene, Lundgren, J. D., Powderly, B., Shortman, N., Moecklinghoff, C., Reilly, G., Franquet, X., Sabin, C. A., Phillips, A., Kirk, O., Reiss, P., Weber, R., Pradier, C., Law, M., d'Arminio Monforte, A., Dabis, F., El-Sadr, W. M., De Wit, S., Ryom, L., Kamara, D., Smith, C., Mocroft, A., Tverland, J., Mansfeld, M., Nielsen, J., Raben, D., Salbøl Brandt, R., Rickenbach, M., Fanti, I., Krum, E., Hillebregt, M., Geffard, S., Sundström, A., Delforge, M., Fontas, E., Torres, F., Mcmanus, H., Wright, S., Kjær, J., Sjøl, A., Meidahl, P., Helweg-Larsen, J., Schmidt Iversen, J., Ross, M., Fux, C. A., Morlat, P., Moranne, O., Kesselring, A. M., Kamara, D. A., Friis-Møller, N., Kowalska, J., Sabin, C., Bruyand, M., Bower, M., Fätkenheuer, G., Donald, A., Grulich, A., Prins, J. M., Kuijpers, T. W., Scherpbier, H. J., van der Meer, J. T. M., Wit, F. W. M. N., Godfried, M. H., van der Poll, T., Nellen, F. J. B., Geerlings, S. E., van Vugt, M., Pajkrt, D., Bos, J. C., Wiersinga, W. J., van der Valk, M., Goorhuis, A., Hovius, J. W., van Eden, J., Henderiks, A., van Hes, A. M. H., Mutschelknauss, M., Nobel, H. E., Pijnappel, F. J. J., Westerman, A. M., Jurriaans, S., Back, N. K. T., Zaaijer, H. L., Berkhout, B., Cornelissen, M. T. E., Schinkel, C. J., Thomas, X. V., van den Berge, M., Stegeman, A., Baas, S., Hage de Looff, L., Versteeg, D., Pronk, M. J. H., Ammerlaan, H. S. M., Korsten-Vorstermans, E. M. H. M., de Munnik, E. S., Jansz, A. R., Tjhie, J., Wegdam, M. C. A., Deiman, B., Scharnhorst, V., van der Plas, A., Weijsenfeld, A. M., van der Ende, M. E., de Vries-Sluijs, T. E. M. S., C. M. van Gorp, E., Schurink, C. A. M., Nouwen, J. L., Verbon, A., Rijnders, B. J. A., Bax, H. I., Hassing, R. J., van der Feltz, M., Bassant, N., van Beek, J. E. A., Vriesde, M., van Zonneveld, L. M., de Oude-Lubbers, A., van den Berg-Cameron, H. J., Bruinsma-Broekman, F. B., de Groot, J., de Zeeuw- de Man, M., Broekhoven-Kruijne, M. J., Schutten, M., Osterhaus, A. D. M. E., Boucher, C. A. B., Driessen, G. J. A., van Rossum, A. M. C., van der Knaap, L. C., Visser, E., Branger, J., H. M. Duijf-van de Ven, C. J., Schippers, E. F., van Nieuwkoop, C., Brimicombe, R. W., van IJperen, J. M., van der Hut, G., Franck, P. F. H., van Eeden, A., Brokking, W., Groot, M., Damen, M., Kwa, I. S., Groeneveld, P. H. P., Bouwhuis, J. W., van den Berg, J. F., van Hulzen, A. G. W., van der Bliek, G. L., Bor, P. C. J., Bloembergen, P., Wolfhagen, M. J. H. M., Ruijs, G. J. H. M., van Lelyveld, S. F. L., Soetekouw, R., Hulshoff, N., van der Prijt, L. M. M., Schoemaker, M., Bermon, N., van der Reijden, W. A., Jansen, R., Herpers, B. L., Veenendaal, D., Kroon, F. P., Arend, S. M., de Boer, M. G. J., Bauer, M. P., Jolink, H., Vollaard, A. M., Dorama, W., Moons, C., Claas, E. C. J., Kroes, A. C. M., den Hollander, J. G., Pogany, K., Kastelijns, M., Smit, J. V., Smit, E., Bezemer, M., van Niekerk, T., Pontesilli, O., Lowe, S. H., Oude Lashof, A., Posthouwer, D., Ackens, R. P., Schippers, J., Vergoossen, R., Weijenberg Maes, B., Savelkoul, P. H. M., Loo, I. H., Weijer, S., El Moussaoui, R., Heitmuller, M., Kortmann, W., van Twillert, G., Cohen Stuart, J. W. T., Diederen, B. M. W., Pronk, D., van Truijen-Oud, F. A., Leyten, E. M. S., Gelinck, L. B. S., van Hartingsveld, A., Meerkerk, C., Wildenbeest, G. S., Mutsaers, J. A. E. M., Jansen, C. L., van Vonderen, M. G. A., van Houte, D. P. F., Dijkstra, K., Faber, S., Weel, J., Kootstra, G. J., Delsing, C. E., van der Burg-van de Plas, M., Heins, H., Lucas, E., Brinkman, K., Frissen, P. H. J., Blok, W. L., Schouten, W. E. M., Bosma, A. S., Brouwer, C. J., Geerders, G. 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L., Dimitrakaki, A., Gargalianos-Kakolyris, P., Giannaris, M., Karafoulidou, A., Katsambas, A., Katsarou, O., Kontos, A. N., Kordossis, T., Lazanas, M. K., Panagopoulos, P., Paparizos, V., Papastamopoulos, V., Petrikkos, G., Skoutelis, A., Tsogas, N., Bergin, C. J., Mooka, B., Mamorksy, M. G., Agmon-Levin, N., Karplus, R., Shahar, E., Biglino, A., De Gioanni, M., Montroni, M., Raise, E., Honda, M., Ishisaka, M., Caplinskas, S., Uzdaviniene, V., Schmit, J. C., Mills, G. D., Blackmore, T., Masters, J. A., Morgan, J., Pithie, A., Brunn, J., Ormasssen, V., La Rosa, A., Guerra, O., Espichan, M., Gutierrez, L., Mendo, F., Salazar, R., Knytz, B., Kwiatkowski, J., Castro, R. S., Horta, A., Miranda, A. C., Pinto, I. V., Vera, J., Vinogradova, E., Yakovlev, A., Wood, R., Orrel, C., Arnaiz, J. A., Carrillo, R., Dalmau, D., Jordano, Q., Knobel, H., Larrousse, M., Moreno, J. S., Oretaga, E., Pena, J. N., Spycher, R., Bottone, S., Christen, A., Franc, C., Furrer, H. J., Gayet-Ageron, A., Genné, D., Hochstrasser, S., Moens, C., Nüesch, R., Ruxrungtham, K., Pumpradit, W., Dangthongdee, S., Kiertiburanakul, S., Klinbuayaem, V., Mootsikapun, P., Nonenoy, S., Piyavong, B., Prasithsirikul, W., Raksakulkarn, P., Gazzard, B. G., Ainsworth, J. G., Angus, B. J., Barber, T. J., Brook, M. G., Care, C. D., Chadwick, D. R., Chikohora, M., Churchill, D. R., Cornforth, D., Dockrell, D. H., Easterbrook, P. J., Fox, P. A., Gomez, P. A., Gompels, M. M., Harris, G. M., Herman, S., Jackson, A. G. A., Jebakumar, S. P. R., Kinghorn, G. R., Kuldanek, K. A., Larbalestier, N., Lumsden, M., Maher, T., Mantell, J., Muromba, L., Orkin, C. M., Peters, B. S., Peto, T. E. A., Portsmouth, S. D., Rajamanoharan, S., Ronan, A., Schwenk, A., Slinn, M. A., Stroud, C. J., Thomas, R. C., Wansbrough-Jones, M. H., Whiles, H. J., White, D. J., Williams, E., Williams, I. G., Acosta, E. A., Adamski, A., Antoniskis, D., Aragon, D. R., Barnett, B. J., Baroni, C., Barron, M., Baxter, J. D., Beers, D., Beilke, M., Bemenderfer, D., Bernard, A., Besch, C. L., Bessesen, M. T., Bethel, J. T., Blue, S., Blum, J. D., Boarden, S., Bolan, R. K., Borgman, J. B., Brar, I., Braxton, B. K., Bredeek, U. F., Brennan, R., Britt, D. E., Bulgin-Coleman, D., Bullock, D. E., Campbell, B., Caras, S., Carroll, J., Casey, K. K., Chiang, F., Cindrich, R. B., Clark, C., Cohen, C., Coley, J., Condoluci, D. V., Contreras, R., Corser, J., Cozzolino, J., Daley, L., Dandridge, D., D'Antuono, V., Darcourt Rizo Patron, J. G., Dehovitz, J. A., Dejesus, E., Desjardin, J., Dietrich, C., Dolce, E., Erickson, D., Faber, L. L., Falbo, J., Farrough, M. J., Farthing, C. F., Ferrell-Gonzalez, P., Flynn, H., Frank, M., Freeman, K. F., French, N., Fujita, N., Gahagan, L., Gilson, I., Goetz, M. B., Goodwin, E., Guity, C. K., Gulick, P., Gunderson, E. R., Hale, C. M., Hannah, K., Henderson, H., Hennessey, K., Henry, W. K., Higgins, D. T., Hodder, S. L., Horowitz, H. W., Howe-Pittman, M., Hubbard, J., Hudson, R., Hunter, H., Hutelmyer, C., Insignares, M. T., Jackson, L., Jenny, L., Johnson, D. L., Johnson, G., Johnson, J., Kaatz, J., Kaczmarski, J., Kagan, S., Kantor, C., Kempner, T., Kieckhaus, K., Kimmel, N., Klaus, B. M., Koeppe, J. R., Koirala, J., Kopka, J., Kostman, J. R., Kozal, M. J., Kumar, A., Lampiris, H., Lamprecht, C., Lattanzi, K. M., Lee, J., Leggett, J., Long, C., Loquere, A., Loveless, K., Lucasti, C. J., Macveigh, M., Makohon, L. H., Markowitz, N. P., Marks, C., Martorell, C., Mcfeaters, E., Mcgee, B., Mcintyre, D. M., Mcmanus, E., Melecio, L. G., Melton, D., Mercado, S., Merrifield, E., Mieras, J. A., Mogyoros, M., Moran, F. M., Murphy, K., Mutic, S., Nadeem, I., Nadler, J. P., Ognjan, A., O'Hearn, M., O'Keefe, K., Okhuysen, P. C., Oldfield, E., Olson, D., Orenstein, R., Ortiz, R., Parpart, F., Pastore-Lange, V., Paul, S., Pavlatos, A., Pearce, D. D., Pelz, R., Peterson, S., Pitrak, D., Powers, S. L., Pujet, H. C., Raaum, J. W., Ravishankar, J., Reeder, J., Reilly, N. A., Reyelt, C., Riddell, J., Rimland, D., Robinson, M. L., Rodriguez, A. E., Rodriguez-Barradas, M. C., Rodriguez Derouen, V., Rosmarin, C., Rossen, W. L., Rouff, J. R., Sampson, J. H., Sands, M., Savini, C., Schrader, S., Schulte, M. M., Scott, R., Seedhom, H., Sension, M., Sheble-Hall, A., Shuter, J., Slater, L. N., Slotten, R., Smith, M., Snap, S., States, D. M., Stringer, G., Summers, K. K., Swanson, K., Sweeton, I. B., Szabo, S., Tedaldi, E. M., Telzak, E. E., Thompson, M. A., Thompson, S., Ting Hong Bong, C., Vaccaro, A., Vasco, L. M., Vecino, I., Verlinghieri, G. K., Visnegarwala, F., Wade, B. H., Weis, S. E., Weise, J. A., Weissman, S., Wilkin, A. M., Witter, J. H., Wojtusic, L., Wright, T. J., Yeh, V., Young, B., Zeana, C., Zeh, J., Savio, E., Vacarezza, M., University College of London [London] (UCL), University of Copenhagen = Københavns Universitet (KU), University of New South Wales [Sydney] (UNSW), University of Amsterdam [Amsterdam] (UvA), University of Minnesota [Twin Cities] (UMN), University of Minnesota System, Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 (AIDMP), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Centre Hospitalier Universitaire de Nice (CHU Nice), Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Med Microbiol, Infect Dis & Infect Prev, RS: NUTRIM - R3 - Chronic inflammatory disease and wasting, RS: CAPHRI School for Public Health and Primary Care, RS: CAPHRI - R4 - Health Inequities and Societal Participation, Interne Geneeskunde, Chemical Biology, Mocroft, A, Lundgren, J, Ross, M, Law, M, Reiss, P, Kirk, O, Smith, C, Wentworth, D, Neuhaus, J, Fux, C, Moranne, O, Morlat, P, Johnson, M, Ryom, L, Gori, A, Internal medicine, CCA - Innovative therapy, ICaR - Circulation and metabolism, Medical Microbiology and Infection Prevention, CCA - Disease profiling, CCA - Immuno-pathogenesis, Plastic, Reconstructive and Hand Surgery, Mocroft, Amanda, Lundgren, Jens D., Ross, Michael, Law, Matthew, Reiss, Peter, Kirk, Ole, Smith, Colette, Wentworth, Deborah, Neuhaus, Jacqueline, Fux, Christoph A., Moranne, Olivier, Morlat, Phillipe, Johnson, Margaret A., Ryom, Lene, D:a:d Study, Group, Castagna, Antonella, the Royal Free Hospital Clinic, Cohort, and the, Insight, Smart, and ESPRIT, Study, Clinicum, Department of Medicine, Herrada, Anthony, University of Copenhagen = Københavns Universitet (UCPH), AII - Amsterdam institute for Infection and Immunity, APH - Amsterdam Public Health, Global Health, Other departments, Infectious diseases, Paediatric Infectious Diseases / Rheumatology / Immunology, General Internal Medicine, Center of Experimental and Molecular Medicine, Graduate School, Gastroenterology and Hepatology, Dermatology, ACS - Amsterdam Cardiovascular Sciences, Other Research, Anesthesiology, and Bartlett, John

Subjects
Male, Adult, Age Factors, Anti-HIV Agents, CD4 Lymphocyte Count, Clinical Decision-Making, Comorbidity, Female, HIV, HIV Infections, HIV Seropositivity, Humans, Incidence, Kidney, Middle Aged, Prospective Studies, Renal Insufficiency, Chronic, Risk, Risk Assessment, Sex Factors, urologic and male genital diseases, Biochemistry, 0302 clinical medicine, ANTIRETROVIRAL THERAPY, Adult, Age Factors, Anti-HIV Agents, CD4 Lymphocyte Count, Clinical Decision-Making, Comorbidity, Female, HIV, HIV Infections, HIV Seropositivity, Humans, Incidence, Kidney, Male, Middle Aged, Prospective Studies, Renal Insufficiency, Chronic, Risk, Risk Assessment, Sex Factors, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Age Factor, Chronic, STAGE RENAL-DISEASE, PROTEINURIA, virus diseases, 11 Medical And Health Sciences, General Medicine, ASSOCIATION, 6. Clean water, female genital diseases and pregnancy complications, 3. Good health, HIV/AIDS, Medicine, Infection, psychological phenomena and processes, Human, medicine.medical_specialty, Renal function, NEFROPATIAS, chronic kidney disease, risk score model, 12. Responsible consumption, ESPRIT study group, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Clinical Research, D:A:D study group, Intensive care medicine, medicine (all), Molecular Biology, Royal Free Hospital Clinic Cohort, Prevention, Anti-HIV Agent, medicine.disease, Prospective Studie, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], Immunology, Kidney Disease, PREDICTION, POSITIVE PERSONS, 030232 urology & nephrology, Sex Factor, SDG 3 – Goede gezondheid en welzijn, Medical and Health Sciences, GLOMERULAR-FILTRATION-RATE, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, INSIGHT study group, HIV Infection, LIFE EXPECTANCY, 030212 general & internal medicine, Renal Insufficiency, Prospective cohort study, Framingham Risk Score, Incidence (epidemiology), adult, age factors, anti-hiv agents, CD4 lymphocyte count, clinical decision-making, comorbidity, female, hiv, hiv infections, hiv seropositivity, humans, incidence, kidney, male, middle aged, prospective studies, renal insufficiency, chronic, risk, risk assessment, sex factors, SMART study group, 6.1 Pharmaceuticals, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Patient Safety, Risk assessment, Biotechnology, Research Article, Settore MED/17 - MALATTIE INFETTIVE, NO, A:D study group [D], General & Internal Medicine, Diabetes mellitus, mental disorders, medicine, EXPOSURE, business.industry, Evaluation of treatments and therapeutic interventions, Cell Biology, [SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, INDIVIDUALS, Good Health and Well Being, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, 3121 General medicine, internal medicine and other clinical medicine, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Kidney disease
Abstract

Background Chronic kidney disease (CKD) is a major health issue for HIV-positive individuals, associated with increased morbidity and mortality. Development and implementation of a risk score model for CKD would allow comparison of the risks and benefits of adding potentially nephrotoxic antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice. Methods and Findings A total of 17,954 HIV-positive individuals from the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study with ≥3 estimated glomerular filtration rate (eGFR) values after 1 January 2004 were included. Baseline was defined as the first eGFR > 60 ml/min/1.73 m2 after 1 January 2004; individuals with exposure to tenofovir, atazanavir, atazanavir/ritonavir, lopinavir/ritonavir, other boosted protease inhibitors before baseline were excluded. CKD was defined as confirmed (>3 mo apart) eGFR ≤ 60 ml/min/1.73 m2. Poisson regression was used to develop a risk score, externally validated on two independent cohorts. In the D:A:D study, 641 individuals developed CKD during 103,185 person-years of follow-up (PYFU; incidence 6.2/1,000 PYFU, 95% CI 5.7–6.7; median follow-up 6.1 y, range 0.3–9.1 y). Older age, intravenous drug use, hepatitis C coinfection, lower baseline eGFR, female gender, lower CD4 count nadir, hypertension, diabetes, and cardiovascular disease (CVD) predicted CKD. The adjusted incidence rate ratios of these nine categorical variables were scaled and summed to create the risk score. The median risk score at baseline was −2 (interquartile range –4 to 2). There was a 1:393 chance of developing CKD in the next 5 y in the low risk group (risk score < 0, 33 events), rising to 1:47 and 1:6 in the medium (risk score 0–4, 103 events) and high risk groups (risk score ≥ 5, 505 events), respectively. Number needed to harm (NNTH) at 5 y when starting unboosted atazanavir or lopinavir/ritonavir among those with a low risk score was 1,702 (95% CI 1,166–3,367); NNTH was 202 (95% CI 159–278) and 21 (95% CI 19–23), respectively, for those with a medium and high risk score. NNTH was 739 (95% CI 506–1462), 88 (95% CI 69–121), and 9 (95% CI 8–10) for those with a low, medium, and high risk score, respectively, starting tenofovir, atazanavir/ritonavir, or another boosted protease inhibitor. The Royal Free Hospital Clinic Cohort included 2,548 individuals, of whom 94 individuals developed CKD (3.7%) during 18,376 PYFU (median follow-up 7.4 y, range 0.3–12.7 y). Of 2,013 individuals included from the SMART/ESPRIT control arms, 32 individuals developed CKD (1.6%) during 8,452 PYFU (median follow-up 4.1 y, range 0.6–8.1 y). External validation showed that the risk score predicted well in these cohorts. Limitations of this study included limited data on race and no information on proteinuria. Conclusions Both traditional and HIV-related risk factors were predictive of CKD. These factors were used to develop a risk score for CKD in HIV infection, externally validated, that has direct clinical relevance for patients and clinicians to weigh the benefits of certain antiretrovirals against the risk of CKD and to identify those at greatest risk of CKD., Editors’ Summary Background About 35 million people are currently infected with HIV, the virus that causes AIDS. HIV destroys CD4 lymphocytes and other immune system cells, leaving infected individuals susceptible to other infections. HIV infection can be controlled, but not cured, using combination antiretroviral therapy (cART), and, nowadays, the life expectancy of many HIV-positive individuals is similar to that of HIV-negative people. HIV-positive individuals nevertheless experience some illnesses more frequently than HIV-negative people do. For example, up to a third of HIV-positive individuals develop chronic kidney disease (CKD), which is associated with an increased risk of cardiovascular disease and death. Persons with CKD may have an impaired effect of the filtration units in the kidneys that remove waste products and excess water from the blood to make urine, thereby leading to a reduced blood filtration rate (the estimated glomerular filtration rate [eGFR]) and waste product accumulation in the blood. Symptoms of CKD, which rarely occur until the disease is advanced, include tiredness, swollen feet, and frequent urination. Advanced stages of CKD cannot be cured, but its progression can be slowed by, for example, controlling hypertension (high blood pressure) and diabetes (two CDK risk factors) and by adopting a healthy lifestyle. Why Was This Study Done? The burden of CKD may increase among HIV-positive individuals as they age, and clinicians need to know which individuals are at high risk of developing CKD when choosing cART regimens for their patients. In addition, clinicians need to be able to identify those HIV-positive individuals at greatest risk of CKD so that they can monitor them for early signs of kidney disease. Some antiretroviral drugs—for example, tenofovir and atazanavir/ritonavir (a boosted protease inhibitor)—are associated with kidney damage. Clinicians may need to weigh the benefits and risks of giving such potentially nephrotoxic drugs to individuals who already have a high CKD risk. Here, the researchers develop and validate a simple, widely applicable risk score (a risk prediction model) for CKD among HIV-positive individuals and investigate the relationship between CKD and potentially nephrotoxic antiretroviral drugs among individuals with different CKD risk score profiles. What Did the Researchers Do and Find? To develop their CKD risk score, the researchers used clinical and demographic data collected from 17,954 HIV-positive individuals enrolled in the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study who had an eGFR > 60 ml/min/1.73 m2 and were not taking a potentially nephrotoxic antiretroviral at baseline. During 103,185 person-years of follow-up, 641 individuals developed CKD. Older age, intravenous drug use, hepatitis C coinfection, lower baseline eGFR, female gender, lower CD4 count nadir, hypertension, diabetes, and cardiovascular disease predicted CKD. The researchers included these nine factors in their risk score model (which is available online) and defined three risk groups: low (risk score < 0), medium (risk score 0–4), and high (risk score ≥ 5) risk of CKD development in the next five years. Specifically, there was a 1 in 393, 1 in 47, and 1 in 6 chance of developing CKD in the next five years in the low, medium, and high risk groups, respectively. Because some patients started to use potentially nephrotoxic antiretroviral drugs during follow-up, the researchers were able to use their risk score model to calculate how many patients would have to be treated with one of these drugs for an additional patient to develop CKD over five years in each risk group. This “number needed to harm” (NNTH) for patients starting treatment with tenofovir, atazanavir/ritonavir, or another boosted protease inhibitor was 739, 88, and 9 in the low, medium, and high risk groups, respectively. Finally, the researchers validated the accuracy of their risk score in two independent HIV study groups. What Do These Findings Mean? These findings provide a simple, validated risk score for CKD and indicate that the NNTH when starting potentially nephrotoxic antiretrovirals was low among HIV-positive individuals at the highest risk of CKD (i.e., treating just nine individuals with nephrotoxic antiretroviral drugs will likely lead to an additional case of CKD in five years). Although various aspects of the study, including the lack of data on race, limit the accuracy of these findings, these findings highlight the need for monitoring, screening, and chronic disease prevention to minimize the risk of HIV-positive individuals developing diabetes, hypertension, or cardiovascular disease, or becoming coinfected with hepatitis C, all of which contribute to the CKD risk score. Moreover, the development of a tool for estimating an individual’s five-year risk of developing CKD with or without the addition of potentially nephrotoxic antiretroviral drugs will enable clinicians and patients to weigh the benefits of certain antiretroviral drugs against the risk of CKD and make informed decisions about treatment options. Additional Information Please access these websites via the online version of this summary at http://dx.doi.org/10.1371/journal.pmed.1001809. Information is available from the US National Institute of Allergy and Infectious Diseases on HIV infection and AIDS NAM/aidsmap provides basic information about HIV/AIDS, summaries of recent research findings on HIV care and treatment, and personal stories about living with AIDS/HIV Information is available from Avert, an international AIDS charity, on many aspects of HIV/AIDS, including personal stories about living with HIV/AIDS The World Health Organization provides information on all aspects of HIV/AIDS (in several languages), including its guidelines on the use of ART for treating and preventing HIV infection The UNAIDS World AIDS Day Report 2014 provides up-to-date information about the AIDS epidemic and efforts to halt it The UK National Health Service Choices website provides information for patients on chronic kidney disease, including some personal stories The US National Kidney Foundation, a not-for-profit organization, provides information about chronic kidney disease (in English and Spanish) A tool for calculating the CDK risk score developed in this study is available Additional information about the D:A:D study is available, Amanda Mocroft and colleagues develop and validate a model for determining risk of developing chronic kidney disease for individuals with HIV if treated with different antiretroviral therapies.

Published
2015
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81. Associations between bride price obligations and women’s anger, symptoms of mental distress, poverty, spouse and family conflict and preoccupations with injustice in conflict-affected Timor-Leste

Author

Rees, S, Mohsin, M, Tay, AK, Thorpe, R, Murray, S, Savio, E, Fonseca, M, Tol, W, Silove, D, Rees, S, Mohsin, M, Tay, AK, Thorpe, R, Murray, S, Savio, E, Fonseca, M, Tol, W, and Silove, D

Abstract

Objectives: Bride price is a widespread custom in many parts of the world, including in most countries in sub-Saharan Africa and parts of Asia. We hypothesised that problems relating to the obligatory ongoing remittances made by the husband and his family to the bride’s family may be a source of mental disturbance (in the form of explosive anger and severe mental distress) among women. In addition, we postulated that problems arising with bride price would be associated with conflict with the spouse and family, poverty and women’s preoccupations with injustice. Design: A mixed-methods study comprising a total community household survey and semistructured qualitative interviews. Setting: Two villages, one urban, the other rural, in Timor-Leste. Participants: 1193 married women participated in the household survey and a structured subsample of 77 women participated in qualitative interviews. Results: Problems with bride price showed a consistent dose–effect relationship with sudden episodes of explosive anger, excessive anger and severe psychological distress. Women with the most severe problems with bride price had twice the poverty scores as those with no problems with the custom. Women with the most severe problems with bride price also reported a threefold increase in conflict with their spouse and a fivefold increase in conflict with family. They also reported heightened preoccupations with injustice. Conclusions: Our study is the first to show consistent associations between problems with bride price obligations and mental distress, poverty, conflict with spouse and family and preoccupations with injustice among women in a low-income, postconflict country.

Published
2016

82. X-ray computed tomography for wear measurement of prosthetic components

Author

Simone Carmignato, Zanini, F., Balcon, M., and Savio, E.

Subjects
X-ray computed tomography, Prosthetics, Volume measurement, Wear measurements, Comparison with measurements, Computerized tomography, Wear-testing, Precision engineering, Joint prostheses, Nanotechnology, Prosthetic components, Prosthetic joints, Coordinate measuring machines, Joint prostheses, Nanotechnology, Precision engineering, Prosthetics, Tomography, Volume measurement, Comparison with measurements, Dimensional Metrology, Prosthetic components, Prosthetic joints, Wear measurements, Wear volume, Wear-testing, X-ray computed tomography, Tomography, Dimensional Metrology, Wear volume, Coordinate measuring machines
Published
2014

85. Development and Validation of a Risk Score for Chronic Kidney Disease in HIV Infection Using Prospective Cohort Data from the D:A:D Study

Author

Mocroft, A., Lundgren, J. D., Ross, M., Law, M., Reiss, P., Kirk, O., Smith, C., Wentworth, D., Neuhaus, J., Fux, C. A., Moranne, O., Morlat, P., Johnson, M. A., Ryom, L., Powderly, B., Shortman, N., Moecklinghoff, C., Reilly, G., Franquet, X., Sabin, C. A., Phillips, A., Weber, R., Pradier, C., d'Arminio Monforte, A., Dabis, F., El-Sadr, W. M., De Wit, S., Kamara, D., Tverland, J., Mansfeld, M., Nielsen, J., Raben, D., Salbol Brandt, R., Rickenbach, M., Fanti, I., Krum, E., Hillebregt, M., Geffard, S., Sundstrom, A., Delforge, M., Fontas, E., Torres, F., Mcmanus, H., Wright, S., Kjaer, J., Sjol, A., Meidahl, P., Helweg-Larsen, J., Schmidt Iversen, J., Kesselring, A. M., Friis-Moller, N., Kowalska, J., Sabin, C., Bruyand, M., Kamara, D. A., Bower, M., Fatkenheuer, G., Donald, A., Grulich, A., Prins, J. M., Kuijpers, T. W., Scherpbier, H. J., van der Meer, J. T. M., Wit, F. W. M. N., Godfried, M. H., van der Poll, T., Nellen, F. J. B., Geerlings, S. E., van Vugt, M., Pajkrt, D., Bos, J. C., Wiersinga, W. J., van der Valk, M., Goorhuis, A., Hovius, J. W., van Eden, J., Henderiks, A., van Hes, A. M. H., Mutschelknauss, M., Nobel, H. E., Pijnappel, F. J. J., Westerman, A. M., Jurriaans, S., Back, N. K. T., Zaaijer, H. L., Berkhout, B., Cornelissen, M. T. E., Schinkel, C. J., Thomas, X. V., van den Berge, M., Stegeman, A., Baas, S., Hage de Looff, L., Versteeg, D., Pronk, M. J. H., Ammerlaan, H. S. M., Korsten-Vorstermans, E. M. H. M., de Munnik, E. S., Jansz, A. R., Tjhie, J., Wegdam, M. C. A., Deiman, B., Scharnhorst, V., van der Plas, A., Weijsenfeld, A. M., van der Ende, M. E., de Vries-Sluijs, T. E. M. S., C. M. van Gorp, E., Schurink, C. A. M., Nouwen, J. L., Verbon, A., Rijnders, B. J. A., Bax, H. I., Hassing, R. J., van der Feltz, M., Bassant, N., van Beek, J. E. A., Vriesde, M., van Zonneveld, L. M., de Oude-Lubbers, A., van den Berg-Cameron, H. J., Bruinsma-Broekman, F. B., de Groot, J., de Zeeuw- de Man, M., Broekhoven-Kruijne, M. J., Schutten, M., Osterhaus, A. D. M. E., Boucher, C. A. B., Driessen, G. J. A., van Rossum, A. M. C., van der Knaap, L. C., Visser, E., Branger, J., H. M. Duijf-van de Ven C., J., Schippers, E. F., van Nieuwkoop, C., Brimicombe, R. W., van IJperen, J. M., van der Hut, G., Franck, P. F. H., van Eeden, A., Brokking, W., Groot, M., Damen, M., Kwa, I. S., Groeneveld, P. H. P., Bouwhuis, J. W., van den Berg, J. F., van Hulzen, A. G. W., van der Bliek, G. L., Bor, P. C. J., Bloembergen, P., Wolfhagen, M. J. H. M., Ruijs, G. J. H. M., van Lelyveld, S. F. L., Soetekouw, R., Hulshoff, N., van der Prijt, L. M. M., Schoemaker, M., Bermon, N., van der Reijden, W. A., Jansen, R., Herpers, B. L., Veenendaal, D., Kroon, F. P., Arend, S. M., de Boer, M. G. J., Bauer, M. P., Jolink, H., Vollaard, A. M., Dorama, W., Moons, C., Claas, E. C. J., Kroes, A. C. M., den Hollander, J. G., Pogany, K., Kastelijns, M., Smit, J. V., Smit, E., Bezemer, M., van Niekerk, T., Pontesilli, O., Lowe, S. H., Oude Lashof, A., Posthouwer, D., Ackens, R. P., Schippers, J., Vergoossen, R., Weijenberg Maes, B., Savelkoul, P. H. M., Loo, I. H., Weijer, S., El Moussaoui, R., Heitmuller, M., Kortmann, W., van Twillert, G., Cohen Stuart, J. W. T., Diederen, B. M. W., Pronk, D., van Truijen-Oud, F. A., Leyten, E. M. S., Gelinck, L. B. S., van Hartingsveld, A., Meerkerk, C., Wildenbeest, G. S., Mutsaers, J. A. E. M., Jansen, C. L., van Vonderen, M. G. A., van Houte, D. P. F., Dijkstra, K., Faber, S., Weel, J., Kootstra, G. J., Delsing, C. E., van der Burg-van de Plas, M., Heins, H., Lucas, E., Brinkman, K., Frissen, P. H. J., Blok, W. L., Schouten, W. E. M., Bosma, A. S., Brouwer, C. J., Geerders, G. F., Hoeksema, K., Kleene, M. J., van der Meche, I. B., Toonen, A. J. M., Wijnands, S., van Ogtrop, M. L., Koopmans, P. P., Keuter, M., van der Ven, A. J. A. M., ter Hofstede, H. J. M., Dofferhoff, A. S. 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S., Patel, S., Pierone, G., Poblete, R., Potter, A., Preston, E., Rappoport, C., Regevik, N., Reyelt, M., Riney, L., Rodriguez-Barradas, M., Rodriguez, M., Rodriguez, J., Roland, R., Rosmarin-DeStefano, C., Rossen, W., Rouff, J., Saag, M., Santiago, S., Sarria, J., Wirtz, S., Schmidt, U., Scott, C., Sheridan, A., Shin, A., Shrader, S., Slowinski, D., Smith, K., Spotkov, J., Sprague, C., States, D., Suh, C., Sullivan, J., Summers, K., Sweeton, B., Tan, V., Tanner, T., Temesgen, Z., Thomas, D., Thompson, M., Tobin, C., Toro, N., Towner, W., Upton, K., Uy, J., Valenti, S., van der Horst, C., Vita, J., Voell, J., Walker, J., Walton, T., Wason, K., Watson, V., Wellons, A., Weise, J., White, M., Whitman, T., Williams, B., Williams, N., Windham, J., Witt, M., Workowski, K., Wortmann, G., Wright, T., Zelasky, C., Zwickl, B., Finley, E., Dietz, D., Chesson, C., Vjecha, M., Schmetter, B., Grue, L., Willoughby, M., Demers, A., Dragsted, U. B., Jensen, K. B., Jansson, P. O., Jensen, B. G., Benfield, T. L., Darbyshire, J. H., Babiker, A. G., Fleck, S. L., Collaco-Moraes, Y., Wyzydrag, L., Drummond, F. M., Connor, S. A., Satchell, C. S., Gunn, S., Delfino, M. A., Merlin, K., Mcginley, C., Neaton, J. D., George, M., Grund, B., Hogan, C., Miller, C., Roediger, M. P., Thackeray, L., Campbell, C., Lahart, C., Perlman, D., Rein, M., Dersimonian, R., Brody, B. A., Daar, E. S., Dubler, N. N., Fleming, T. R., Freeman, D. J., Kahn, J. P., Kim, K. M., Medoff, G., Modlin, J. F., Moellering, R., Murray, B. E., Robb, M. L., Scharfstein, D. O., Sugarman, J., Tsiatis, A., Tuazon, C., Zoloth, L., Belloso, W. H., Losso, M. H., Benetucci, J. A., Bogdanowicz, E. P., Cahn, P. E., Casiro, A. D., Cassetti, I., Contarelli, J. M., Corral, J. A., Crinejo, A., David, D. O., Ishida, M. T., Laplume, H. E., Lasala, M. B., Lupo, S. H., Masciottra, F., Michaan, M., Ruggieri, L., Salazar, E., Allworth, A. M., Anderson, J. S. C., Armishaw, J., Barnes, K., Chiam, A., Chuah, J. C. P., Curry, M. C., Dever, R. L., Donohue, W. A., Doong, N. C., Dwyer, D. E., Dyer, J., Eu, B., Ferguson, V. W., French, M. A. H., Garsia, R. J., Hudson, J. H., Jeganathan, S., Konecny, P., Mccormack, C. L., Mcmurchie, M., Moore, R. J., Moussa, M. B., Piper, M., Read, T., Roney, J. J., Shaw, D. R., Silvers, J., Smith, D. J., Street, A. C., Vale, R. J., Wendt, N. A., Wood, H., Youds, D. W., Zillman, J., Tozeau, V., de Roo, A., Leonard, P., Lynen, L., Moutschen, M., Pereira, L. C., Souza, T. N. L., Schechter, M., Zajdenverg, R., Almeida, M. M. T. B., Araujo, F., Bahia, F., Brites, C., Caseiro, M. M., Casseb, J., Etzel, A., Falco, G. G., Filho, E. C. J., Flint, S. R., Gonzales, C. R., Madruga, J. V. R., Passos, L. N., Reuter, T., Sidi, L. C., Toscano, A. L. C., Cherban, E., Conway, B., Dufour, C., Foster, A., Haase, D., Haldane, H., Klein, M., Lessard, B., Martel, A., Martel, C., Paradis, E., Schlech, W., Schmidt, S., Thompson, B., Vezina, S., Wolff Reyes, M. J., Northland, R., Hergens, L., Loftheim, I. R., Raukas, M., Justinen, J., Landman, R., Abel, S., Abgrall, S., Amat, K., Auperin, L., Barruet, R., Benalycherif, A., Benammar, N., Bentata, M., Besnier, J. M., Blanc, M., Cabie, A., Chavannet, P., Dargere, S., de la Tribonniere, X., Debord, T., Decaux, N., Delgado, J., Frixon-Marin, V., Genet, C., Gerard, L., Gilquin, J., Jeantils, V., Kouadio, H., Leclercq, P., Lelievre, J. -D., Michon, C. P., Nau, P., Pacanowski, J., Piketty, C., Salmon, D., Schmit, J. L., Serini, M. A., Tassi, S., Touam, F., Verdon, R., Weinbreck, P., Yazdanpanah, Y., Yeni, P., Bitsch, S., Bogner, J. R., Goebel, F. D., Lehmann, C., Lennemann, T., Potthof, A., Wasmuth, J. C., Wiedemeyer, K., Hatzakis, A., Touloumi, G., Antoniadou, A., Daikos, G. L., Dimitrakaki, A., Gargalianos-Kakolyris, P., Giannaris, M., Karafoulidou, A., Katsambas, A., Katsarou, O., Kontos, A. N., Kordossis, T., Lazanas, M. K., Panagopoulos, P., Paparizos, V., Papastamopoulos, V., Petrikkos, G., Skoutelis, A., Tsogas, N., Bergin, C. J., Mooka, B., Mamorksy, M. G., Agmon-Levin, N., Karplus, R., Shahar, E., Biglino, A., De Gioanni, M., Montroni, M., Raise, E., Honda, M., Ishisaka, M., Caplinskas, S., Uzdaviniene, V., Schmit, J. C., Mills, G. D., Blackmore, T., Masters, J. A., Morgan, J., Pithie, A., Brunn, J., Ormasssen, V., La Rosa, A., Guerra, O., Espichan, M., Gutierrez, L., Mendo, F., Salazar, R., Knytz, B., Kwiatkowski, J., Castro, R. S., Horta, A., Miranda, A. C., Pinto, I. V., Vera, J., Vinogradova, E., Yakovlev, A., Wood, R., Orrel, C., Arnaiz, J. A., Carrillo, R., Dalmau, D., Jordano, Q., Knobel, H., Larrousse, M., Moreno, J. S., Oretaga, E., Pena, J. N., Spycher, R., Bottone, S., Christen, A., Franc, C., Furrer, H. J., Gayet-Ageron, A., Genne, D., Hochstrasser, S., Moens, C., Nuesch, R., Ruxrungtham, K., Pumpradit, W., Dangthongdee, S., Kiertiburanakul, S., Klinbuayaem, V., Mootsikapun, P., Nonenoy, S., Piyavong, B., Prasithsirikul, W., Raksakulkarn, P., Gazzard, B. G., Ainsworth, J. G., Angus, B. J., Barber, T. J., Brook, M. G., Care, C. D., Chadwick, D. R., Chikohora, M., Churchill, D. R., Cornforth, D., Dockrell, D. H., Easterbrook, P. J., Fox, P. A., Gomez, P. A., Gompels, M. M., Harris, G. M., Herman, S., Jackson, A. G. A., Jebakumar, S. P. R., Kinghorn, G. R., Kuldanek, K. A., Larbalestier, N., Lumsden, M., Maher, T., Mantell, J., Muromba, L., Orkin, C. M., Palfreeman, A. J., Peters, B. S., Peto, T. E. A., Portsmouth, S. D., Rajamanoharan, S., Ronan, A., Schwenk, A., Slinn, M. A., Stroud, C. J., Thomas, R. C., Wansbrough-Jones, M. H., Whiles, H. J., White, D. J., Williams, E., Williams, I. G., Acosta, E. A., Adamski, A., Antoniskis, D., Aragon, D. R., Barnett, B. J., Baroni, C., Barron, M., Baxter, J. D., Beers, D., Beilke, M., Bemenderfer, D., Bernard, A., Besch, C. L., Bessesen, M. T., Bethel, J. T., Blue, S., Blum, J. D., Boarden, S., Bolan, R. K., Borgman, J. B., Brar, I., Braxton, B. K., Bredeek, U. F., Brennan, R., Britt, D. E., Bulgin-Coleman, D., Bullock, D. E., Campbell, B., Caras, S., Carroll, J., Casey, K. K., Chiang, F., Cindrich, R. B., Clark, C., Cohen, C., Coley, J., Condoluci, D. V., Contreras, R., Corser, J., Cozzolino, J., Daley, L., Dandridge, D., D'Antuono, V., Darcourt Rizo Patron, J. G., Dehovitz, J. A., Dejesus, E., Desjardin, J., Dietrich, C., Dolce, E., Erickson, D., Faber, L. L., Falbo, J., Farrough, M. J., Farthing, C. F., Ferrell-Gonzalez, P., Flynn, H., Frank, M., Freeman, K. F., French, N., Fujita, N., Gahagan, L., Gilson, I., Goetz, M. B., Goodwin, E., Guity, C. K., Gulick, P., Gunderson, E. R., Hale, C. M., Hannah, K., Henderson, H., Hennessey, K., Henry, W. K., Higgins, D. T., Hodder, S. L., Horowitz, H. W., Howe-Pittman, M., Hubbard, J., Hudson, R., Hunter, H., Hutelmyer, C., Insignares, M. T., Jackson, L., Jenny, L., Johnson, D. L., Johnson, G., Johnson, J., Kaatz, J., Kaczmarski, J., Kagan, S., Kantor, C., Kempner, T., Kieckhaus, K., Kimmel, N., Klaus, B. M., Koeppe, J. R., Koirala, J., Kopka, J., Kostman, J. R., Kozal, M. J., Kumar, A., Lampiris, H., Lamprecht, C., Lattanzi, K. M., Lee, J., Leggett, J., Long, C., Loquere, A., Loveless, K., Lucasti, C. J., Macveigh, M., Makohon, L. H., Markowitz, N. P., Marks, C., Martorell, C., Mcfeaters, E., Mcgee, B., Mcintyre, D. M., Mcmanus, E., Melecio, L. G., Melton, D., Mercado, S., Merrifield, E., Mieras, J. A., Mogyoros, M., Moran, F. M., Murphy, K., Mutic, S., Nadeem, I., Nadler, J. P., Ognjan, A., O'Hearn, M., O'Keefe, K., Okhuysen, P. C., Oldfield, E., Olson, D., Orenstein, R., Ortiz, R., Parpart, F., Pastore-Lange, V., Paul, S., Pavlatos, A., Pearce, D. D., Pelz, R., Peterson, S., Pitrak, D., Powers, S. L., Pujet, H. C., Raaum, J. W., Ravishankar, J., Reeder, J., Reilly, N. A., Reyelt, C., Riddell, J., Rimland, D., Robinson, M. L., Rodriguez, A. E., Rodriguez-Barradas, M. C., Rodriguez Derouen, V., Rosmarin, C., Rossen, W. L., Rouff, J. R., Sampson, J. H., Sands, M., Savini, C., Schrader, S., Schulte, M. M., Scott, R., Seedhom, H., Sension, M., Sheble-Hall, A., Shuter, J., Slater, L. N., Slotten, R., Smith, M., Snap, S., States, D. M., Stringer, G., Summers, K. K., Swanson, K., Sweeton, I. B., Szabo, S., Telzak, E. E., Thompson, M. A., Thompson, S., Ting Hong Bong, C., Vaccaro, A., Vasco, L. M., Vecino, I., Verlinghieri, G. K., Visnegarwala, F., Wade, B. H., Weis, S. E., Weise, J. A., Weissman, S., Wilkin, A. M., Witter, J. H., Wojtusic, L., Wright, T. J., Yeh, V., Young, B., Zeana, C., Zeh, J., Savio, E., Vacarezza, M., and Cauda R. (ORCID:0000-0002-1498-4229)

Abstract

Chronic kidney disease (CKD) is a major health issue for HIV-positive individuals, associated with increased morbidity and mortality. Development and implementation of a risk score model for CKD would allow comparison of the risks and benefits of adding potentially nephrotoxic antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice. A total of 17,954 HIV-positive individuals from the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study with ≥3 estimated glomerular filtration rate (eGFR) values after 1 January 2004 were included. Baseline was defined as the first eGFR > 60 ml/min/1.73 m2 after 1 January 2004; individuals with exposure to tenofovir, atazanavir, atazanavir/ritonavir, lopinavir/ritonavir, other boosted protease inhibitors before baseline were excluded. CKD was defined as confirmed (>3 mo apart) eGFR ≤ 60 ml/min/1.73 m2. Poisson regression was used to develop a risk score, externally validated on two independent cohorts. In the D:A:D study, 641 individuals developed CKD during 103,185 person-years of follow-up (PYFU; incidence 6.2/1,000 PYFU, 95% CI 5.7–6.7; median follow-up 6.1 y, range 0.3–9.1 y). Older age, intravenous drug use, hepatitis C coinfection, lower baseline eGFR, female gender, lower CD4 count nadir, hypertension, diabetes, and cardiovascular disease (CVD) predicted CKD. The adjusted incidence rate ratios of these nine categorical variables were scaled and summed to create the risk score. The median risk score at baseline was −2 (interquartile range –4 to 2). There was a 1:393 chance of developing CKD in the next 5 y in the low risk group (risk score < 0, 33 events), rising to 1:47 and 1:6 in the medium (risk score 0–4, 103 events) and high risk groups (risk score ≥ 5, 505 events)

Published
2015

86. Preface

Author

Marinello, F., Passeri, Daniele, and Savio, E.

Published
2013

87. Ethyl biodiesel: Microwave irradiation aiding ethanolysis of waste cooking oil

Author

Barbosa, Sandro L., Miranda, Savio E. O., Klein, Stanlei Ivair [UNESP], Hurtado, Gabriela R., Baroni, Adriano C. M., Dabdoub, Miguel J., and Universidade Estadual Paulista (Unesp)

Abstract

Made available in DSpace on 2015-05-15T13:30:24Z (GMT). No. of bitstreams: 0 Previous issue date: 2013 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) We describe a methodology to produce biodiesel of excellent quality from waste cooking oil, NaOH catalyst and ethanol, by accelerating the transesterification reaction with microwave irradiation from an unmodified household microwave owen. The resulting Waste Cooking Oil Ethyl Esters were evaluated according to the physical and chemical properties demanded by regulatory standards for biodiesels, and a brief discussion of the meaning and scope of these quality control parameters directly related to biodiesel is also presented. Keywords: Ethylic Biodiesel; Waste Cooking Oil; Microwave Irradiation; Biotechnology; Quality Control; Biofuel. Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Química Geral e Inorgânica, Instituto de Química de Araraquara, Araraquara, Rua Professor Francisco Degni S/N, Quitandinha, CEP 14800-900, SP, Brasil Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Química Geral e Inorgânica, Instituto de Química de Araraquara, Araraquara, Rua Professor Francisco Degni S/N, Quitandinha, CEP 14800-900, SP, Brasil Department of Pharmacy - Biochemistry, Universidade Federal dos Vales do Jequitinhonha e Mucuri, R. da Glória, 187 Centro, Diamantina, MG, CEP, Brazil, CEP 39100-000 Department of General and Inorganic Chemistry, Institute of Chemistry, São Paulo State University – UNESP, R. Prof. Francisco Degni s/n, Quitandinha, Araraquara, SP, Brazil, CEP 14800-900 Department of Chemistry and Pharmacy,Universidade Federal do Mato Grosso do Sul, Cidade Universitária, Campo Grande, MS, Brazil, CEP 79070-900 Department of Chemistry, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, University of São Paulo, Av. Bandeirantes 3900, Monte Alegre, CEP 14040-901, Ribeirão Preto, SP, Brazil

Published
2013

88. Detection, treatment, and prevention of carbapenemase-producing Enterobacteriaceae: Recommendations from an international working group

Author

Hara, G.L. Gould, I. Endimiani, A. Pardo, P.R. Daikos, G. Hsueh, P.-R. Mehtar, S. Petrikkos, G. Casellas, J.M. Daciuk, L. Paciel, D. Novelli, A. Saginur, R. Pryluka, D. Medina, J. Savio, E.

Abstract

The prevalence of carbapenemase-producing Enterobacteriaceae (CPE) has increased during the past 10 years. Its detection is frequently difficult, because they do not always show a minimum inhibitory concentration (MIC) value for carbapenems in the resistance range. Both broth microdilution and agar dilution methods are more sensitive than disk diffusion method, Etest and automated systems. Studies on antimicrobial treatment are based on a limited number of patients; therefore, the optimal treatment is not well established. Combination therapy with two active drugs appears to be more effective than monotherapy. Combination of a carbapenem with another active agent - preferentially an aminoglycoside or colistin - could lower mortality provided that the MIC is ≤4 mg/l and probably ≤8 mg/l, and is administered in a higher-dose/prolonged-infusion regimen. An aggressive infection control and prevention strategy is recommended, including reinforcement of hand hygiene, using contact precautions and early detection of CPE through use of targeted surveillance. © 2013 Edizioni Scientifiche per l'Informazione su Farmaci e Terapia.

Published
2013

92. MINIMA OF ECLIPSING BINARIES AND NEW EPHEMERIDES FOR GSC 03881-00579 AND EZ LACERTAE

Author

Banfi, M., Aceti, P., Arena, C., Bianciardi, G., Bonaventura, G., Chiappini, M., Corfini, G., Jacopo Maria De Ponti, Savio, E. L., Lucidi, F., Marchini, A., Marino, G., Martinengo, M., Nasimi, H., Pesenti, L., Prandoni, F., Ruocco, N., Salvaggio, F., Vincenzi, M., and Zambelli, R.

Subjects
GSC 03881-00579, Variable stars, Eclipsing binaries Minima, data analysis, EZ Lacertae, Variable stars, data analysis, Eclipsing binaries Minima, GSC 03881-00579
Published
2012

95. The PHEMU09 catalogue and astrometric results of the observations of the mutual occultations and eclipses of the Galilean satellites of Jupiter made in 2009

Author

Arlot, J. -E., Emelyanov, N., Varfolomeev, M. I., Amossé, A., Arena, C., Assafin, M., Barbieri, L., Bolzoni, S., Bragas-Ribas, F., Camargo, J. I. B., Casarramona, F., Casas, R., Christou, A., Colas, F., Collard, A., Combe, S., Constantinescu, M., Dangl, G., De, Cat, P., Degenhardt, S., Delcroix, M., Dias-Oliveira, A., Dourneau, G., Douvris, A., Druon, C., Ellington, C. K., Estraviz, G., Farissier, P., Farmakopoulos, A., Garlitz, J., Gault, D., George, T., Gorda, S. Y., Grismore, J., Guo, D. F., Herald, D., Ida, M., Ishida, M., Ivanov, A. V., Klemt, B., Koshkin, N., Le, Campion, J. F., Liakos, A., Liao, S. L., Li, S. N., Loader, B., Lopresti, C., Lo, Savio, E., Marchini, A., Marino, G., Masi, G., Massallé, A., Maulella, R., Mcfarland, J., Miyashita, K., Napoli, C., Noyelles, B., Pauwels, T., Pavlov, H., Peng, Q. Y., Perelló, C., Priban, V., Prost, J., Razemon, S., Rousselle, J. P., Rovira, J., Ruisi, R., Ruocco, N., Salvaggio, F., Sbarufatti, G., Shakun, L., Scheck, A., Sciuto, C., Da, Silva, Neto, D. N., V, Sinyaeva, N., Sofia, A., Sonka, A., Talbot, J., Tang, Z. H., Tejfel, V. G., Thuillot, W., Tigani, K., Timerson, B., Tontodonati, E., Tsamis, V., Unwin, M., Venable, R., Vieira-Martins, R., Vilar, J., Vingerhoets, P., Watanabe, H., Yin, H. X., Yu, Y., Zambelli, R., Arlot, J. -E., Emelyanov, N., Varfolomeev, M. I., Amossé, A., Arena, C., Assafin, M., Barbieri, L., Bolzoni, S., Bragas-Ribas, F., Camargo, J. I. B., Casarramona, F., Casas, R., Christou, A., Colas, F., Collard, A., Combe, S., Constantinescu, M., Dangl, G., De, Cat, P., Degenhardt, S., Delcroix, M., Dias-Oliveira, A., Dourneau, G., Douvris, A., Druon, C., Ellington, C. K., Estraviz, G., Farissier, P., Farmakopoulos, A., Garlitz, J., Gault, D., George, T., Gorda, S. Y., Grismore, J., Guo, D. F., Herald, D., Ida, M., Ishida, M., Ivanov, A. V., Klemt, B., Koshkin, N., Le, Campion, J. F., Liakos, A., Liao, S. L., Li, S. N., Loader, B., Lopresti, C., Lo, Savio, E., Marchini, A., Marino, G., Masi, G., Massallé, A., Maulella, R., Mcfarland, J., Miyashita, K., Napoli, C., Noyelles, B., Pauwels, T., Pavlov, H., Peng, Q. Y., Perelló, C., Priban, V., Prost, J., Razemon, S., Rousselle, J. P., Rovira, J., Ruisi, R., Ruocco, N., Salvaggio, F., Sbarufatti, G., Shakun, L., Scheck, A., Sciuto, C., Da, Silva, Neto, D. N., V, Sinyaeva, N., Sofia, A., Sonka, A., Talbot, J., Tang, Z. H., Tejfel, V. G., Thuillot, W., Tigani, K., Timerson, B., Tontodonati, E., Tsamis, V., Unwin, M., Venable, R., Vieira-Martins, R., Vilar, J., Vingerhoets, P., Watanabe, H., Yin, H. X., Yu, Y., and Zambelli, R.

Abstract

Context. In 2009, the Sun and the Earth passed through the equatorial plane of Jupiter and therefore the orbital planes of its main satellites. It was the equinox on Jupiter. This occurrence made mutual occultations and eclipses between the satellites possible. Experience has shown that the observations of such events provide accurate astrometric data able to bring new information on the dynamics of the Galilean satellites. Observations are made under the form of photometric measurements, but need to be made through the organization of a worldwide observation campaign maximizing the number and the quality of the data obtained. Aims. This work focuses on processing the complete database of photometric observations of the mutual occultations and eclipses of the Galilean satellites of Jupiter made during the international campaign in 2009. The final goal is to derive new accurate astrometric data. Methods. We used an accurate photometric model of mutual events adequate with the accuracy of the observation. Our original method was applied to derive astrometric data from photometric observations of mutual occultations and eclipses of the Galilean satellites of Jupiter. Results. We processed the 457 lightcurves obtained during the international campaign of photometric observations of the Galilean satellites of Jupiter in 2009. Compared with the theory, for successful observations, the r.m.s. of O-C residuals are equal to 45.8 mas and 81.1 mas in right ascension and declination, respectively; the mean O-C residuals are equal to -2 mas and -9 mas in right ascension and declination, respectively, for mutual occultations; and -6 mas and +1 mas in right ascension and declination, respectively, for mutual eclipses. © ESO, 2014.

Published
2014

100. The PHEMU09 catalogue and astrometric results of the observations of the mutual occultations and eclipses of the Galilean satellites of Jupiter made in 2009

Author

Arlot, J.-E., primary, Emelyanov, N., additional, Varfolomeev, M. I., additional, Amossé, A., additional, Arena, C., additional, Assafin, M., additional, Barbieri, L., additional, Bolzoni, S., additional, Bragas-Ribas, F., additional, Camargo, J. I. B., additional, Casarramona, F., additional, Casas, R., additional, Christou, A., additional, Colas, F., additional, Collard, A., additional, Combe, S., additional, Constantinescu, M., additional, Dangl, G., additional, De Cat, P., additional, Degenhardt, S., additional, Delcroix, M., additional, Dias-Oliveira, A., additional, Dourneau, G., additional, Douvris, A., additional, Druon, C., additional, Ellington, C. K., additional, Estraviz, G., additional, Farissier, P., additional, Farmakopoulos, A., additional, Garlitz, J., additional, Gault, D., additional, George, T., additional, Gorda, S. Yu., additional, Grismore, J., additional, Guo, D. F., additional, Herald, D., additional, Ida, M., additional, Ishida, M., additional, Ivanov, A. V., additional, Klemt, B., additional, Koshkin, N., additional, Le Campion, J. F., additional, Liakos, A., additional, Liao, S. L., additional, Li, S. N., additional, Loader, B., additional, Lopresti, C., additional, Lo Savio, E., additional, Marchini, A., additional, Marino, G., additional, Masi, G., additional, Massallé, A., additional, Maulella, R., additional, McFarland, J., additional, Miyashita, K., additional, Napoli, C., additional, Noyelles, B., additional, Pauwels, T., additional, Pavlov, H., additional, Peng, Q. Y., additional, Perelló, C., additional, Priban, V., additional, Prost, J., additional, Razemon, S., additional, Rousselle, J. P., additional, Rovira, J., additional, Ruisi, R., additional, Ruocco, N., additional, Salvaggio, F., additional, Sbarufatti, G., additional, Shakun, L., additional, Scheck, A., additional, Sciuto, C., additional, da Silva Neto, D. N., additional, V Sinyaeva, N., additional, Sofia, A., additional, Sonka, A., additional, Talbot, J., additional, Tang, Z. H., additional, Tejfel, V. G., additional, Thuillot, W., additional, Tigani, K., additional, Timerson, B., additional, Tontodonati, E., additional, Tsamis, V., additional, Unwin, M., additional, Venable, R., additional, Vieira-Martins, R., additional, Vilar, J., additional, Vingerhoets, P., additional, Watanabe, H., additional, Yin, H. X., additional, Yu, Y., additional, and Zambelli, R., additional

Published
2014
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