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51. The State of Ebooks in Libraries

Author

Scardilli, Brandi

Subjects
United States. Department of Education -- Reports, Academic libraries -- Statistics -- User statistics, Public libraries -- Statistics -- User statistics, E-books -- Statistics -- User statistics, Education, Graphic novels, Audiobooks, Technology, Electronic book, Business, Library and information science
Abstract

A recent Campus Technology article notes that according to statistics from the U.S. Department of Education, 'library collections in higher education now contain more digital items than physical' (campustechnology.com/ articles/2018/12/12/digital-dominatesin-college-libraries.aspx). [...]

Published
2019

54. Happy New Year!

Author

Scardilli, Brandi

Subjects
Business, Library and information science
Abstract

Welcome to the first issue of 2023. To start the new year off on a positive note, I talked to info pros about what they're looking forward to (page 20). [...]

Published
2023

57. Fond Farewells

Author

Scardilli, Brandi

Subjects
Business, Library and information science
Abstract

Are there people out there who actually like change? If you're one of them, please teach me how to have your attitude. I have trouble dealing with all change, even [...]

Published
2022

60. Cover Image

Author

Jaconi, M., Manzoni, M., Pincelli, A. I., Giardini, V., Scardilli, M., Smith, A., Fellegara, G., and Pagni, F.

Published
2017
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61. Clinical-pathological issues in thyroid pathology: study on the routine application of NIFTP diagnostic criteria

Author

Mattia Garancini, Davide Leni, Marcella Scardilli, Angela Ida Pincelli, Valentina Canini, Fabio Pagni, Giulia Capitoli, Riccardo Cimini, Camillo Di Bella, Biagio Eugenio Leone, Chiara Villa, Canini, V, Leni, D, Pincelli, A, Scardilli, M, Garancini, M, Villa, C, Di Bella, C, Capitoli, G, Cimini, R, Leone, B, and Pagni, F

Subjects
Adult, Male, Cell biology, medicine.medical_specialty, Thyroid pathology, Science, Thyroid Gland, Age at diagnosis, 030209 endocrinology & metabolism, Context (language use), Article, Lesion, 03 medical and health sciences, 0302 clinical medicine, Preoperative Care, medicine, Humans, Thyroid Neoplasms, Pathological, Aged, Aged, 80 and over, Multidisciplinary, business.industry, Incidence (epidemiology), Biological techniques, Middle Aged, thyroid carcinoma, 030220 oncology & carcinogenesis, Medicine, Female, Radiology, medicine.symptom, Indeterminate, Who classification, business
Abstract

In 2017, the WHO classification of tumours of the endocrine organs established the criteria for a NIFTP diagnosis. The present paper considers some aspects that are still debated or unresolved: the real incidence and clinical meaning of multifocal/multinodular lesions, the biological behaviour of micro-NIFTP, the sprinkling phenomenon and the corresponding modifications to the FNA reporting systems based on changes to the ROM. Moreover, the paper suggests possible scenarios for the clinical-pathological management of this entity. From the initial 1470 cases, a group of 68 NIFTPs was recruited in a 9 year-long period. The average age at diagnosis was 55 years. The average diameter of the lesion was 1.7 cm (0.1 cm–10 cm). In 41 cases (60.1%), the lesion was inserted in the context of a multinodular background. In 12 cases, the diagnosis was incidental and the pre- operative FNA was performed on a different target. In 10 out of 68 cases, there was a multifocal NIFTP; in 14.7% of patients, PTC-like nuclear features showed sprinkling phenomenon. The cytological revision allocated 21 cases (49%) to the SIAPEC TIR3 indeterminate class and a nuclear score 2 or 3 were identified in 25 smears. Multifocality is part of the spectrum of NIFTPs, that can arise in a multinodular background with variable sizes from microscopic lesions to very large ones. Cytopathological criteria such as an evaluation of the nuclear score may help the pathologists in promoting a NIFTP diagnosis in the preoperative setting.

Published
2019

62. At the Forefront of Promoting Inclusivity

Author

Scardilli, Brandi

Subjects
Public libraries -- Officials and employees, Religions, Sexuality, Displays (Marketing), Signage, Email, Skin, Libraries, Business, Library and information science
Abstract

It is no surprise that library signage tends to be inclusive: Book displays, event fliers, posters, and other artwork communicate that all are welcome. Rebecca McCorkindale, assistant library director/creative director [...]

Published
2019

63. We've Got Content Covered

Author

Scardilli, Brandi

Subjects
Business, Library and information science
Abstract

The job of the information professional to help people find, sort, understand, and make use of all kinds of content is a daunting one. Information Today aims to help info [...]

Published
2022

64. You Good?

Author

Scardilli, Brandi

Subjects
Business, Library and information science
Abstract

There are some things that are just as good as we expect them to be, such as cracking open a brand-new book, sliding into clean sheets at bedtime, and the [...]

Published
2022

65. Teaching Emerging Tech at NCSU Libraries

Author

Scardilli, Brandi

Subjects
Academic libraries -- Conferences, meetings and seminars, Visualization (Computer) -- Conferences, meetings and seminars, College faculty -- Conferences, meetings and seminars -- Training, Business, Library and information science
Abstract

Imagine that you notice a need for technical skills training at your university. You think that students, faculty members, and staffers should know how to interact with tools such as [...]

Published
2018

66. The Power of Books Takes Center Stage at PLA

Author

Scardilli, Brandi

Subjects
Librarians -- Conferences, meetings and seminars, Public libraries -- Conferences, meetings and seminars, Business, Library and information science, American Library Association. Public Library Association -- Conferences, meetings and seminars
Abstract

Yet another recent ALA conference was affected by snowy conditions--there were sessions canceled, and some booth personnel were unable to reach Philadelphia for the Public Library Association (PLA) 2018 Conference. [...]

Published
2018

67. Librarians Talk Oscar Nominees

Author

Scardilli, Brand

Subjects
Darkest Hour (Motion picture), Dunkirk (Motion picture), Call Me by Your Name (Motion picture), Movies, Business, Library and information science
Abstract

Whether or not filmmakers set out to create a movie with a message, theatergoers will assign meaning to their films (or they may see messages the filmmakers didn't intend). How [...]

Published
2018

68. Plano Public Library Breaks Down Technology Barriers

Author

Scardilli, Brandi

Subjects
Public libraries -- Achievements and awards -- Social aspects, Community education -- Methods, Business, Library and information science
Abstract

The ALA/Information Today, Inc. Library of the Future Award is presented to an organization that plans, develops, and applies a patron-training program that explores IT in a library setting. The [...]

Published
2021

69. ILS product roundup: choosing among the top discovery services

Author

Scardilli, Brandi

Subjects
Ex Libris Ltd. -- Services, ProQuest L.L.C. -- Services, EBSCO Information Services -- Services, Computer software industry -- Services, Database industry -- Services, Information services industry -- Services, Information services -- Services, Database industry, Information services industry, Computers, Library and information science
Abstract

All libraries need to facilitate discovery of their content, and the type of library you operate may determine the best discovery service to choose. One of ITI's editors has gathered [...]

Published
2016

70. Molecular trait of follicular-patterned thyroid neoplasms defined by MALDI-imaging

Author

Piga, I, Capitoli, G, Clerici, F, Brambilla, V, Leni, D, Scardilli, M, Canini, V, Cipriani, N, Bono, F, Valsecchi, M, Galimberti, S, Magni, F, Pagni, F, Piga, Isabella, Capitoli, Giulia, Clerici, Francesca, Brambilla, Virginia, Leni, Davide, Scardilli, Marcella, Canini, Valentina, Cipriani, Nicole, Bono, Francesca, Valsecchi, Maria Grazia, Galimberti, Stefania, Magni, Fulvio, Pagni, Fabio, Piga, I, Capitoli, G, Clerici, F, Brambilla, V, Leni, D, Scardilli, M, Canini, V, Cipriani, N, Bono, F, Valsecchi, M, Galimberti, S, Magni, F, Pagni, F, Piga, Isabella, Capitoli, Giulia, Clerici, Francesca, Brambilla, Virginia, Leni, Davide, Scardilli, Marcella, Canini, Valentina, Cipriani, Nicole, Bono, Francesca, Valsecchi, Maria Grazia, Galimberti, Stefania, Magni, Fulvio, and Pagni, Fabio

Abstract

In the field of thyroid neoplasms, the most interesting recent change regards the introduction of a new terminology for follicular-patterned thyroid tumors, named Noninvasive Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP). This pre-malignant tumor is considered to be the putative precursor of invasive carcinomas. However, given that several issues are still unresolved, the application of ancillary tools, based on omics-techniques, may improve the clinical management of these challenging cases. The present paper highlights the proteomic profiles of a series of NIFTPs submitted to Fine Needle Aspirations (FNAs) and analysed by MALDI-imaging in order to confirm the heterogeneous phenotype of nodules included in the present NIFTP terminology and to underline the necessity of more accurate biomarkers that can be used for their characterization. Ethical and economic implications in terms of healthcare costs, operative risks, morbidity, as well as the potential need for lifelong hormone replacement therapy, seem to be significant reasons to approach the characterization of NIFTPs using alternative tools such as MALDI-MSI.

Published
2020

71. Future Prep

Author

Scardilli, Brandi

Subjects
Business, Library and information science
Abstract

It may be summer in our part of the world--a time to relax and rejuvenate while the days are long and the weather's nice--but Information Today is aiming to keep [...]

Published
2022

72. Summer Movie (Streaming) Season

Author

Scardilli, Brandi

Subjects
Business, Library and information science
Abstract

The summer movie season is upon us, and I'll be venturing out to the theater to see just two--Jurassic World: Dominion and Thor: Love and Thunder. Growing up, I was [...]

Published
2022

73. Molecular trait of follicular-patterned thyroid neoplasms defined by MALDI-imaging

Author

Marcella Scardilli, Francesca Bono, Isabella Piga, Maria Grazia Valsecchi, Francesca Clerici, Davide Leni, Stefania Galimberti, Nicole A. Cipriani, Fabio Pagni, Giulia Capitoli, Virginia Brambilla, Valentina Canini, Fulvio Magni, Piga, I, Capitoli, G, Clerici, F, Brambilla, V, Leni, D, Scardilli, M, Canini, V, Cipriani, N, Bono, F, Valsecchi, M, Galimberti, S, Magni, F, and Pagni, F

Subjects
0301 basic medicine, MALDI imaging, Adult, Male, Proteomics, Biopsy, Fine-Needle, Biophysics, Thyroid fine needle aspiration biopsy, Bioinformatics, medicine.disease_cause, Biochemistry, Analytical Chemistry, Terminology, 03 medical and health sciences, 0302 clinical medicine, Medicine, MALDI-MSI, Humans, Thyroid Neoplasms, Molecular Biology, Thyroid tumors, Thyroid neoplasm, Aged, Invasive carcinoma, business.industry, NIFTP, Thyroid, Middle Aged, Carcinoma, Papillary, 030104 developmental biology, medicine.anatomical_structure, Transgender hormone therapy, 030220 oncology & carcinogenesis, Papillary thyroid carcinoma, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Trait, Female, business
Abstract

In the field of thyroid neoplasms, the most interesting recent change regards the introduction of a new terminology for follicular-patterned thyroid tumors, named Noninvasive Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP). This pre-malignant tumor is considered to be the putative precursor of invasive carcinomas. However, given that several issues are still unresolved, the application of ancillary tools, based on omics-techniques, may improve the clinical management of these challenging cases. The present paper highlights the proteomic profiles of a series of NIFTPs submitted to Fine Needle Aspirations (FNAs) and analysed by MALDI-imaging in order to confirm the heterogeneous phenotype of nodules included in the present NIFTP terminology and to underline the necessity of more accurate biomarkers that can be used for their characterization. Ethical and economic implications in terms of healthcare costs, operative risks, morbidity, as well as the potential need for lifelong hormone replacement therapy, seem to be significant reasons to approach the characterization of NIFTPs using alternative tools such as MALDI-MSI.

Published
2020

74. Update on: proteome analysis in thyroid pathology – part II: overview of technical and clinical enhancement of proteomic investigation of the thyroid lesions

Author

Giulia Capitoli, Davide Leni, Isabella Piga, Fabio Pagni, Andrew Smith, Stefania Galimberti, Marcella Scardilli, Silvia Tettamanti, Stefano Casano, Fulvio Magni, Angela Ida Pincelli, Piga, I, Casano, S, Smith, A, Tettamanti, S, Leni, D, Capitoli, G, Pincelli, A, Scardilli, M, Galimberti, S, Magni, F, and Pagni, F

Subjects
Proteomics, 0301 basic medicine, Thyroid nodules, Bio-fluid sample, Thyroid pathology, Biopsy, Fine-Needle, Thyroid Gland, Computational biology, Biochemistry, Thyroid cancer, 03 medical and health sciences, 0302 clinical medicine, Thyroid Pathology, Humans, Metabolomics, Medicine, Thyroid Neoplasms, Molecular Biology, Mass Spectrometry Imaging, Thyroid nodule, Paraffin Embedding, medicine.diagnostic_test, business.industry, Immunochemistry, Fine needle aspiration biopsie, Thyroid, Proteomic, Blood Proteins, Omics, medicine.disease, Tissues, 030104 developmental biology, Fine-needle aspiration, medicine.anatomical_structure, Genetic Techniques, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, 030220 oncology & carcinogenesis, Proteome, business
Abstract

INTRODUCTION An accurate diagnostic classification of thyroid lesions remains an important clinical aspect that needs to be addressed in order to avoid 'diagnostic' thyroidectomies. Among the several 'omics' techniques, proteomics is playing a pivotal role in the search for diagnostic markers. In recent years, different approaches have been used, taking advantage of the technical improvements related to mass spectrometry that have occurred. Areas covered: The review provides an update of the recent findings in diagnostic classification, in genetic definition and in the investigation of thyroid lesions based on different proteomics approaches and on different type of specimens: cytological, surgical and biofluid samples. A brief section will discuss how these findings can be integrated with those obtained by metabolomics investigations. Expert commentary: Among the several proteomics approaches able to deepen our knowledge of the molecular alterations of the different thyroid lesions, MALDI-MSI is strongly emerging above all. In fact, MS-imaging has also been demonstrated to be capable of distinguishing thyroid lesions, based on their different molecular signatures, using cytological specimens. The possibility to use the material obtained by the fine needle aspiration makes MALDI-MSI a highly promising technology that could be implemented into the clinical and pathological units.

Published
2018
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75. A New Way of Looking at It

Author

Scardilli, Brandi

Subjects
Business, Library and information science
Abstract

To get a fresh perspective on something, you have to take a step back and find a new way of looking at it. This month, our two main features do [...]

Published
2022

76. Book Banning Reaches a Fever Pitch

Author

Scardilli, Brandi

Subjects
Banned books, Business, Library and information science
Abstract

In November 2021, ALA issued a statement condemning the recent uptick in book banning across the U.S., and Every-Library started a petition to lawmakers called Don't Ban Books in the [...]

Published
2022

78. What's Next for Cybersecurity

Author

Scardilli, Brandi

Subjects
Data security -- Forecasts and trends, Cyberterrorism -- Forecasts and trends, Data security issue, Market trend/market analysis, Business, Library and information science
Abstract

With the Equifax and other recent hacks still fresh in people's minds, for Information Today's annual predictions issue I decided to look to various IT companies for guidance on the [...]

Published
2017

79. Summer self-care

Author

Scardilli, Brandi

Subjects
Self care (Health) -- Methods, Vacations -- Planning, Company business planning, Business, Library and information science
Abstract

The concept of self-care can mean different things to different people. According to Wikipedia, 'Self-care includes all health decisions people (as individuals or consumers) make for themselves and their families [...]

Published
2017

80. The Zendy Digital Library Seeks to Build a More Knowledgeable World

Author

Scardilli, Brandi

Subjects
Digital libraries -- Services, Information services -- Innovations -- Forecasts and trends, Market trend/market analysis, Information services industry, Business, Library and information science
Abstract

It seems pretty obvious that 'corona-virus' would be the most-searched term on many digital library platforms lately. The need for evidence-backed information about the pandemic is causing a new entry [...]

Published
2020

81. Rolling Out the Welcome Mat at Broward County Library

Author

Scardilli, Brandi

Subjects
County libraries -- Achievements and awards -- Services -- Technology application, Voice I/O equipment -- Usage, Technology application, Voice I/O device, Business, Library and information science, Amazon Echo (Voice I/O device) -- Usage
Abstract

The ALA/Information Today, Inc. Library of the Future Award is presented to an organization that plans, develops, and applies a patron-training program that explores IT in a library setting. The [...]

Published
2020

82. The Open Technology Fund Fights for Independence

Author

Scardilli, Brandi

Subjects
Federal officials -- Powers and duties -- Appointments, resignations and dismissals, Executive dismissals -- Political aspects -- Cases, Nonprofit organizations -- Aims and objectives -- Officials and employees -- Laws, regulations and rules, Company legal issue, Government regulation, Business, Library and information science
Abstract

The Open Technology Fund (OTF) got some major attention this summer when the president appointed a new, conservative director, Michael Pack, to lead its overseeing body, the U.S. Agency for [...]

Published
2020

83. Making Plans at ALA Midwinter 2020

Author

Scardilli, Brandi

Subjects
Social media, Librarians, Social networks, Public libraries, E-books, Libraries, Publishers (Persons), Business, Library and information science
Abstract

The 2020 ALA Midwinter Meeting & Exhibits (2020.alamidwinter .org) took place Jan. 24-28 in Philadelphia. The first session I attended was Macmillan Publishers CEO John Sargent's Ask Me Anything event, [...]

Published
2020

84. A Better Education

Author

Scardilli, Brandi

Subjects
Business, Library and information science
Abstract

The Civil War wasn't actually about slavery; it was about states' rights. Do you remember hearing some version of this (dangerous misinformation) in school? When I heard it for the [...]

Published
2022

85. Year-End Topics

Author

Scardilli, Brandi

Subjects
Racism, Business, Library and information science
Abstract

As 2021 comes to a close, COVID is still with us (Database Review, page 30), anti-racism education is as important as ever ('Engaging Children in Anti-Racism Work at Your Library,' [...]

Published
2021

86. ‘Indeterminate for malignancy’ (Tir3/Thy3 in the Italian and British systems for classification) thyroid fine needle aspiration (FNA) cytology reporting: morphological criteria and clinical impact

Author

Pagni, F., Prada, M., Goffredo, P., Isimbaldi, G., Crippa, S., Di Bella, C., Leone, B. E., Capra, Maurizio, Colombo, Manuela, Perego, Rita, Pincelli, Angela Ida, Perotti, Mario, Grassi, Guido, Colombo, Giovanni, Giannobi, Paolo, Scardilli, Marcella, and Giardini, Vittorio

Published
2014
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87. Preliminary investigation by liquid chromatography tandem mass spectrometry of perfluorinated compounds presence in bass reared and fished in Italy

Author

Federica Farabegoli, Andrea Barbarossa, Chiara Devicienti, Martina Scardilli, Elisa Zironi, Maurizio Pirini, Anna Badiani, Giampiero Pagliuca, and Teresa Gazzotti

Subjects
Perfluorinated compounds, PFOS, PFOA, Bass, UPLC-MS/MS, Food processing and manufacture, TP368-456
Abstract

The term perfluorinated compounds (PFCs) defines synthetic fully-fluorinated compounds; since the 50s they have been largely employed in a wide range of industrial and consumer applications, due to their chemical and physical properties. Only recently, research on their potential adverse effects on both the environment and human health has been conducted, highlighting carcinogenic activity, toxic effects on reproduction, liver and kidney. Human exposure to PFCs is mainly through diet, and in particular fishery products are one of the most contaminated food. Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) are the two most important and investigated compounds of this group. The aim of this work was to carry out a preliminary monitoring on the presence of these two molecules in 50 bass muscle samples, of which 30 reared and 20 fished, collected from different Italian areas of the Mediterranean Sea. The method used was based on extraction with organic solvent followed by two purification steps: one with salts and one with dispersive solid phase. The extract was finally analysed by means of an ultra performance liquid chromatographytandem mass spectrometric system. Data showed a relevant contamination of this species and evidenced a significant difference of concentrations between fished (PFOS 112.4- >2000 ng/L and PFOA 3.3-487.0 ng/L) and reared basses (PFOS 11.1-104.5 ng/L and PFOA

Published
2013
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88. Clinical-pathological issues in thyroid pathology: study on the routine application of NIFTP diagnostic criteria

Author

Canini, V, Leni, D, Pincelli, A, Scardilli, M, Garancini, M, Villa, C, Di Bella, C, Capitoli, G, Cimini, R, Leone, B, Pagni, F, Canini, Valentina, Leni, Davide, Pincelli, Angela Ida, Scardilli, Marcella, Garancini, Mattia, Villa, Chiara, Di Bella, Camillo, Capitoli, Giulia, Cimini, Riccardo, Leone, Biagio Eugenio, Pagni, Fabio, Canini, V, Leni, D, Pincelli, A, Scardilli, M, Garancini, M, Villa, C, Di Bella, C, Capitoli, G, Cimini, R, Leone, B, Pagni, F, Canini, Valentina, Leni, Davide, Pincelli, Angela Ida, Scardilli, Marcella, Garancini, Mattia, Villa, Chiara, Di Bella, Camillo, Capitoli, Giulia, Cimini, Riccardo, Leone, Biagio Eugenio, and Pagni, Fabio

Abstract

In 2017, the WHO classification of tumours of the endocrine organs established the criteria for a NIFTP diagnosis. The present paper considers some aspects that are still debated or unresolved: the real incidence and clinical meaning of multifocal/multinodular lesions, the biological behaviour of micro-NIFTP, the sprinkling phenomenon and the corresponding modifications to the FNA reporting systems based on changes to the ROM. Moreover, the paper suggests possible scenarios for the clinical-pathological management of this entity. From the initial 1470 cases, a group of 68 NIFTPs was recruited in a 9 year-long period. The average age at diagnosis was 55 years. The average diameter of the lesion was 1.7 cm (0.1 cm–10 cm). In 41 cases (60.1%), the lesion was inserted in the context of a multinodular background. In 12 cases, the diagnosis was incidental and the pre- operative FNA was performed on a different target. In 10 out of 68 cases, there was a multifocal NIFTP; in 14.7% of patients, PTC-like nuclear features showed sprinkling phenomenon. The cytological revision allocated 21 cases (49%) to the SIAPEC TIR3 indeterminate class and a nuclear score 2 or 3 were identified in 25 smears. Multifocality is part of the spectrum of NIFTPs, that can arise in a multinodular background with variable sizes from microscopic lesions to very large ones. Cytopathological criteria such as an evaluation of the nuclear score may help the pathologists in promoting a NIFTP diagnosis in the preoperative setting.

Published
2019

89. Spooky Fun

Author

Scardilli, Brandi

Subjects
Business, Library and information science
Abstract

What's the best Halloween costume you've ever worn? Mine were always homemade, and my favorite was 1998's, when I went as Tim 'The Tool Man' Taylor from Home Improvement. I [...]

Published
2021

90. Buying Power

Author

Scardilli, Brandi

Subjects
Company acquisition/merger, Business, Library and information science
Abstract

When you're thinking about all of the mergers and acquisitions that have occurred in the information and library technology spaces, Computers in Libraries columnist Marshall Breeding's Library Technology Guides chart [...]

Published
2021

91. Working together toward an open source future

Author

Scardilli, Brandi

Subjects
Nonprofit organizations -- Management -- Services, Company business management, Business, Library and information science
Abstract

Libraries have always been spaces where members of a community can gather to gain knowledge, whether through books or through events and activities. But where can library staffers go to [...]

Published
2016

92. The Hall of Fame for American Writers

Author

Scardilli, Brandi

Subjects
Trade and professional associations -- Aims and objectives -- Management -- Ethical aspects, Authors -- Practice, Company business management, Business, Library and information science
Abstract

Bookworms know that a love of reading often involves more than a hunger for stories themselves. Some want to know more about the lives of authors--their backgrounds and their inspirations--to [...]

Published
2016

93. Inside the Knight News Challenge

Author

Scardilli, Brandi

Subjects
Data libraries -- Competitions, Business, Library and information science, Knight Foundation -- Services -- Competitions
Abstract

* The Knight Foundation recently launched its second Knight News Challenge focused on libraries, which poses the question, 'How might libraries serve 21st century information needs?' (newschallenge.org). U.S.-based libraries, businesses, [...]

Published
2016

94. MOOCs: classes for the masses

Author

Scardilli, Brandi

Subjects
College students -- Education, Massive open online courses -- Study and teaching -- Forecasts and trends -- Evaluation, Market trend/market analysis, Business, Library and information science, University of Manitoba -- Services -- Officials and employees -- Curricula
Abstract

In 2008, Stephen Downes and George Siemens developed an online course called Connectivism and Connective Knowledge. Little did they know the trend that they set in motion. The two professors [...]

Published
2013

95. Proteomics in thyroid cytopathology: Relevance of MALDI-imaging in distinguishing malignant from benign lesions

Author

Fabio Pagni, Davide Leni, Marcella Scardilli, Francesca Bono, Fulvio Magni, Mattia Garancini, Gabriele De Sio, Andrew Smith, Clizia Chinello, Pagni, F, De Sio, G, Garancini, M, Scardilli, M, Chinello, C, Smith, A, Bono, F, Leni, D, and Magni, F

Subjects
Male, Proteomics, 0301 basic medicine, Thyroid nodules, Pathology, medicine.medical_specialty, Proteome, Adenoma, Biopsy, Fine-Needle, Thyroid Gland, Biochemistry, Thyroid cancer, Thyroiditis, Diagnosis, Differential, Thyroid carcinoma, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Thyroid Neoplasms, Biomarker discovery, Biomedicine, Cytological smear, MALDI-imaging, Mass spectrometry, Proteomics, Thyroid cancer, Molecular Biology, Cytological smear, Hyperplasia, Mass spectrometry, business.industry, Carcinoma, Thyroid, MALDI-imaging, Proteomic, medicine.disease, Carcinoma, Papillary, Molecular Imaging, Biomedicine, 030104 developmental biology, medicine.anatomical_structure, Thyroid Cancer, Papillary, Cytopathology, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, 030220 oncology & carcinogenesis, Immunology, Female, business
Abstract

Several proteomic strategies are used extensively for the purpose of biomarker discovery and in order to obtain insights into the molecular aspects of cancers, using either body fluids or tissue as samples. Among them, MALDI-imaging can be applied to cytological thyroid specimens to investigate the molecular signatures of different pathological conditions and highlight differences in the proteome that are of relevance for diagnostic and pathogenetic research. In this study, 26 ex-vivo fine needle aspirations from benign thyroid nodules (n = 13) and papillary thyroid carcinomas (n = 13) were analyzed by MALDI-imaging. Based on the specific protein signatures capable of distinguishing the aforementioned patients, MALDI-imaging was able to correctly assign, in blind, the specimens from ten additional FNABs to a malignant or benign class, as later confirmed by the morphological classification. Moreover, some proteins presented a progressive overexpression in malignant phenotypes when compared with Hashimoto's thyroiditis and hyperplastic/follicular adenoma. This data not only suggests that a MALDI-imaging based approach can be a valuable tool in the diagnosis of thyroid lesions but also in the detection of proteins that have a possible role in the promotion of tumorigenic activity.

Published
2016
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96. The Rights Stuff

Author

Scardilli, Brandi

Subjects
Business, Library and information science
Abstract

Have you seen the parody of A Quiet Place, Part II that Brigham Young University Library posted in May? If you haven't, search for 'Quiet Place to Study BYU Library' [...]

Published
2021

97. One Year Later

Author

Scardilli, Brandi

Subjects
Social service, Workplace multiculturalism, Business, Library and information science
Abstract

In June 2020, in response to the May 25 murder of George Floyd by Derek Chauvin (enabled by fellow police officers) and the resulting protests, ALA's Office for Diversity, Literacy [...]

Published
2021

98. Libraries: Days of Future Past

Author

Scardilli, Brandi

Subjects
Vaccines, Libraries, Business, Library and information science
Abstract

I think it's safe to say that most of us have become a little obsessed with the future since the pandemic began. When will the vaccines get here? (Answered!) When [...]

Published
2021

99. Update on: proteome analysis in thyroid pathology - part II: overview of technical and clinical enhancement of proteomic investigation of the thyroid lesions

Author

Piga, I, Casano, S, Smith, A, Tettamanti, S, Leni, D, Capitoli, G, Pincelli, A, Scardilli, M, Galimberti, S, Magni, F, Pagni, F, Piga I, Casano S, Smith A, Tettamanti S, Leni D, Capitoli G, Pincelli AI, Scardilli M, Galimberti S, Magni F, Pagni F., Piga, I, Casano, S, Smith, A, Tettamanti, S, Leni, D, Capitoli, G, Pincelli, A, Scardilli, M, Galimberti, S, Magni, F, Pagni, F, Piga I, Casano S, Smith A, Tettamanti S, Leni D, Capitoli G, Pincelli AI, Scardilli M, Galimberti S, Magni F, and Pagni F.

Abstract

An accurate diagnostic classification of thyroid lesions remains an important clinical aspect that needs to be addressed in order to avoid "diagnostic" thyroidectomies. Among the several "omics" techniques, proteomics is playing a pivotal role in the search for diagnostic markers. In recent years, different approaches have been used, taking advantage of the technical improvements related to mass spectrometry that have occurred. Areas covered: The review provides an update of the recent findings in diagnostic classification, in genetic definition and in the investigation of thyroid lesions based on different proteomics approaches and on different type of specimens: cytological, surgical and biofluid samples. A brief section will discuss how these findings can be integrated with those obtained by metabolomics investigations. Expert commentary: Among the several proteomics approaches able to deepen our knowledge of the molecular alterations of the different thyroid lesions, MALDI-MSI is strongly emerging above all. In fact, MS-imaging has also been demonstrated to be capable of distinguishing thyroid lesions, based on their different molecular signatures, using cytological specimens. The possibility to use the material obtained by the fine needle aspiration makes MALDI-MSI a highly promising technology that could be implemented into the clinical and pathological units

Published
2018

100. Recent Pew Research Center Reports

Author

Scardilli, Brandi

Subjects
Social networks -- Political aspects, Web sites (World Wide Web), Political corruption, Business, Library and information science
Abstract

Information Today sometimes covers the latest surveys and reports from Pew Research Center, 'a nonpartisan fact tank that informs the public about the issues, attitudes and trends shaping America and [...]

Published
2019

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