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1,359 results on '"Schäfers, Michael"'

60. Hybrid cardiac imaging using PET/MRI: a joint position statement by the European Society of Cardiovascular Radiology (ESCR) and the European Association of Nuclear Medicine (EANM)

Author

Nensa, Felix, Bamberg, Fabian, Rischpler, Christoph, Menezes, Leon, Poeppel, Thorsten D., la Fougère, Christian, Beitzke, Dietrich, Rasul, Sazan, Loewe, Christian, Nikolaou, Konstantin, Bucerius, Jan, Kjaer, Andreas, Gutberlet, Matthias, Prakken, Niek H., Vliegenthart, Rozemarijn, Slart, Riemer H. J. A., Nekolla, Stephan G., Lassen, Martin L., Pichler, Bernd J., Schlosser, Thomas, Jacquier, Alexis, Quick, Harald H., Schäfers, Michael, Hacker, Marcus, on behalf of the European Society of Cardiovascular Radiology (ESCR), and the European Association of Nuclear Medicine (EANM) Cardiovascular Committee

Published
2018
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64. A Prognostic Risk Score for Prostate Cancer Based on PSMA PET–derived Organ-specific Tumor Volumes

Author

Seifert, Robert, primary, Rasul, Sazan, additional, Seitzer, Konstantin, additional, Eveslage, Maria, additional, Rahbar Nikoukar, Laya, additional, Kessel, Katharina, additional, Schäfers, Michael, additional, Yu, Josef, additional, Haug, Alexander R., additional, Hacker, Marcus, additional, Bögemann, Martin, additional, Bodei, Lisa, additional, Morris, Michael J., additional, Hofman, Michael S., additional, and Rahbar, Kambiz, additional

Published
2023
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65. Radiomics of Tumor Heterogeneity in 18F-FDG-PET-CT for Predicting Response to Immune Checkpoint Inhibition in Therapy-Naïve Patients with Advanced Non-Small-Cell Lung Cancer

Author

Ventura, David, primary, Schindler, Philipp, additional, Masthoff, Max, additional, Görlich, Dennis, additional, Dittmann, Matthias, additional, Heindel, Walter, additional, Schäfers, Michael, additional, Lenz, Georg, additional, Wardelmann, Eva, additional, Mohr, Michael, additional, Kies, Peter, additional, Bleckmann, Annalen, additional, Roll, Wolfgang, additional, and Evers, Georg, additional

Published
2023
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66. What Is Theranostics?

Author

Weber, Wolfgang A., primary, Barthel, Henryk, additional, Bengel, Frank, additional, Eiber, Matthias, additional, Herrmann, Ken, additional, and Schäfers, Michael, additional

Published
2023
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67. Supplementary Appendix S1 from Fibroblast Activation Protein Triggers Release of Drug Payload from Non-internalizing Small Molecule Drug Conjugates in Solid Tumors

Author

Zana, Aureliano, primary, Galbiati, Andrea, primary, Gilardoni, Ettore, primary, Bocci, Matilde, primary, Millul, Jacopo, primary, Sturm, Theo, primary, Stucchi, Riccardo, primary, Elsayed, Abdullah, primary, Nadal, Lisa, primary, Cirillo, Martina, primary, Roll, Wolfgang, primary, Stegger, Lars, primary, Asmus, Inga, primary, Backhaus, Philipp, primary, Schäfers, Michael, primary, Neri, Dario, primary, and Cazzamalli, Samuele, primary

Published
2023
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68. Supplementary Figure Legends from Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake

Author

Zinnhardt, Bastian, primary, Pigeon, Hayet, primary, Thézé, Benoit, primary, Viel, Thomas, primary, Wachsmuth, Lydia, primary, Fricke, Inga B., primary, Schelhaas, Sonja, primary, Honold, Lisa, primary, Schwegmann, Katrin, primary, Wagner, Stefan, primary, Faust, Andreas, primary, Faber, Cornelius, primary, Kuhlmann, Michael T., primary, Hermann, Sven, primary, Schäfers, Michael, primary, Winkeler, Alexandra, primary, and Jacobs, Andreas H., primary

Published
2023
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69. Suppl. Fig. 3: Illustration of the applied thresholding. from Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake

Author

Zinnhardt, Bastian, primary, Pigeon, Hayet, primary, Thézé, Benoit, primary, Viel, Thomas, primary, Wachsmuth, Lydia, primary, Fricke, Inga B., primary, Schelhaas, Sonja, primary, Honold, Lisa, primary, Schwegmann, Katrin, primary, Wagner, Stefan, primary, Faust, Andreas, primary, Faber, Cornelius, primary, Kuhlmann, Michael T., primary, Hermann, Sven, primary, Schäfers, Michael, primary, Winkeler, Alexandra, primary, and Jacobs, Andreas H., primary

Published
2023
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70. Suppl. Fig. 1: Experimental design. from Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake

Author

Zinnhardt, Bastian, primary, Pigeon, Hayet, primary, Thézé, Benoit, primary, Viel, Thomas, primary, Wachsmuth, Lydia, primary, Fricke, Inga B., primary, Schelhaas, Sonja, primary, Honold, Lisa, primary, Schwegmann, Katrin, primary, Wagner, Stefan, primary, Faust, Andreas, primary, Faber, Cornelius, primary, Kuhlmann, Michael T., primary, Hermann, Sven, primary, Schäfers, Michael, primary, Winkeler, Alexandra, primary, and Jacobs, Andreas H., primary

Published
2023
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71. Suppl. Fig. 2: Workflow of imaging data co-registration. from Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake

Author

Zinnhardt, Bastian, primary, Pigeon, Hayet, primary, Thézé, Benoit, primary, Viel, Thomas, primary, Wachsmuth, Lydia, primary, Fricke, Inga B., primary, Schelhaas, Sonja, primary, Honold, Lisa, primary, Schwegmann, Katrin, primary, Wagner, Stefan, primary, Faust, Andreas, primary, Faber, Cornelius, primary, Kuhlmann, Michael T., primary, Hermann, Sven, primary, Schäfers, Michael, primary, Winkeler, Alexandra, primary, and Jacobs, Andreas H., primary

Published
2023
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72. Data from Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake

Author

Zinnhardt, Bastian, primary, Pigeon, Hayet, primary, Thézé, Benoit, primary, Viel, Thomas, primary, Wachsmuth, Lydia, primary, Fricke, Inga B., primary, Schelhaas, Sonja, primary, Honold, Lisa, primary, Schwegmann, Katrin, primary, Wagner, Stefan, primary, Faust, Andreas, primary, Faber, Cornelius, primary, Kuhlmann, Michael T., primary, Hermann, Sven, primary, Schäfers, Michael, primary, Winkeler, Alexandra, primary, and Jacobs, Andreas H., primary

Published
2023
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73. Suppl. Fig. 4: Influence of imaging sequence. from Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake

Author

Zinnhardt, Bastian, primary, Pigeon, Hayet, primary, Thézé, Benoit, primary, Viel, Thomas, primary, Wachsmuth, Lydia, primary, Fricke, Inga B., primary, Schelhaas, Sonja, primary, Honold, Lisa, primary, Schwegmann, Katrin, primary, Wagner, Stefan, primary, Faust, Andreas, primary, Faber, Cornelius, primary, Kuhlmann, Michael T., primary, Hermann, Sven, primary, Schäfers, Michael, primary, Winkeler, Alexandra, primary, and Jacobs, Andreas H., primary

Published
2023
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74. Suppl. Fig. 5: Assessment of intra-rater reproducibility of the volumetric relation of [18F]DPA-714 and [18F]FET. from Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake

Author

Zinnhardt, Bastian, primary, Pigeon, Hayet, primary, Thézé, Benoit, primary, Viel, Thomas, primary, Wachsmuth, Lydia, primary, Fricke, Inga B., primary, Schelhaas, Sonja, primary, Honold, Lisa, primary, Schwegmann, Katrin, primary, Wagner, Stefan, primary, Faust, Andreas, primary, Faber, Cornelius, primary, Kuhlmann, Michael T., primary, Hermann, Sven, primary, Schäfers, Michael, primary, Winkeler, Alexandra, primary, and Jacobs, Andreas H., primary

Published
2023
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76. Tragverhalten hochfester Verbundstützen und Werkstoffverhalten im Brandfall – FOSTA‐Forschungsverbund HOCHFEST: Projekte „Hochfeste Verbundstützen und Brand“

Author

Knobloch, Markus, primary, Feldmann, Markus, additional, Claßen, Martin, additional, Zehfuß, Jochen, additional, Mensinger, Martin, additional, Uszball, Sara, additional, Schurgacz, Przemyslaw, additional, Schäfers, Michael, additional, Janiak, Till, additional, Nonn, Jonas, additional, Jalaeeyan, Asieh, additional, Ameri, Shaghayegh, additional, Wolters, Kevin, additional, and Röß, Rudolf, additional

Published
2023
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81. 18F-FDG-PET-MRI for the assessment of acute intestinal graft-versus-host-disease (GvHD)

Author

Roll, Wolfgang, Schindler, Philipp, Masthoff, Max, Strotmann, Rebecca, Albring, Jörn Christian, Reicherts, Christian, Weckesser, Matthias, Noto, Benjamin, Stelljes, Matthias, Schäfers, Michael, Evers, Georg Heribert, and Universitäts- und Landesbibliothek Münster

Subjects
GvHD, Inflammation, FDG, 610 Medicine and health, Research, PET-MRI, Medicine and health, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, ddc:610, RC254-282
Abstract

Background: Graft versus host disease (GvHD) is a frequent complication of allogeneic stem cell transplantation (alloSCT), significantly increasing mortality. Previous imaging studies focused on the assessment of intestinal GvHD with contrast-enhanced MRI/CT or 18F-FDG-PET imaging alone. The objective of this retrospective study was to elucidate the diagnostic value of a combined 18F-FDG-PET-MRI protocol in patients with acute intestinal GvHD. Methods: Between 2/2015 and 8/2019, 21 patients with acute intestinal GvHD underwent 18F-FDG-PET-MRI. PET, MRI and PET-MRI datasets were independently reviewed. Readers assessed the number of affected segments of the lower gastrointestinal tract and the reliability of the diagnosis on a 5-point Likert scale and quantitative PET (SUVmax, SUVpeak, metabolic volume (MV)) and MRI parameter (wall thickness), were correlated to clinical staging of acute intestinal GvHD. Results: The detection rate for acute intestinal GvHD was 56.8% for PET, 61.4% for MRI and 100% for PET-MRI. PET-MRI (median Likert-scale value: 5; range: 4–5) offers a significantly higher reliability of the diagnosis compared to PET (median: 4; range: 2–5; p = 0.01) and MRI alone (median: 4; range: 3–5; p = 0.03). The number of affected segments in PET-MRI (rs = 0.677; p < 0.001) and the MV (rs = 0.703; p < 0.001) correlated significantly with the clinical stage. SUVmax (rs = 0.345; p = 0.14), SUVpeak (rs = 0.276; p = 0.24) and wall thickening (rs = 0.174; p = 0.17) did not show a significant correlation to clinical stage. Conclusion: 18F-FDG-PET-MRI allows for highly reliable assessment of acute intestinal GvHD and adds information indicating clinical severity., Finanziert über die DEAL-Vereinbarung mit Wiley 2019-2022.

Published
2023

84. First clinical experience with fractionated intracavitary radioimmunotherapy using [177Lu]Lu-6A10-Fab fragments in patients with glioblastoma: a pilot study.

Author

Roll, Wolfgang, Müther, Michael, Böning, Guido, Delker, Astrid, Warneke, Nils, Gildehaus, Franz-Josef, Schäfers, Michael, Stummer, Walter, Zeidler, Reinhard, Reulen, Hans-Jürgen, and Stegger, Lars

Subjects
RADIOIMMUNOTHERAPY, GLIOBLASTOMA multiforme, CARBONIC anhydrase, SUBCUTANEOUS injections, ABSORBED dose, LUTETIUM compounds
Abstract

Background: Following resection and standard adjuvant radio- and chemotherapy, approved maintenance therapies for glioblastoma are lacking. Intracavitary radioimmunotherapy (iRIT) with 177Lu-labeled 6A10-Fab fragments targeting tumor-associated carbonic anhydrase XII and injected into the resection cavity offers a novel and promising strategy for improved tumor control. Methods: Three glioblastoma patients underwent tumor resection followed by standard radio- and chemotherapy. These patients with stable disease following completion of standard therapy underwent iRIT on compassionate grounds. After surgical implantation of a subcutaneous injection reservoir with a catheter into the resection cavity, a leakage test with [99mTc]Tc-DTPA was performed to rule out leakage into other cerebral compartments. IRIT comprised three consecutive applications over three months for each patient, with 25%, 50%, 25% of the total activity injected. A dosimetry protocol was included with blood sampling and SPECT/CT of the abdomen to calculate doses for the bone marrow and kidneys as potential organs at risk. Results: All three patients presented without relevant leakage after application of [99mTc]Tc-DTPA. Two patients underwent three full cycles of iRIT (592 MBq and 1228 MBq total activity). One patient showed histologically proven tumor progression after the second cycle (526 MBq total activity). No relevant therapy-associated toxicities or adverse events were observed. Dosimetry did not reveal absorbed doses above upper dose limits for organs at risk. Conclusions: In first individual cases, iRIT with [177Lu]Lu-6A10-Fab appears to be feasible and safe, without therapy-related side effects. A confirmatory multicenter phase-I-trial was recently opened and is currently recruiting. [ABSTRACT FROM AUTHOR]

Published
2023
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91. Initial Results of68Ga-FAPI-46 PET/MRI to Assess Response to Neoadjuvant Chemotherapy in Breast Cancer

Author

Backhaus, Philipp, primary, Burg, Matthias C., additional, Asmus, Inga, additional, Pixberg, Michaela, additional, Büther, Florian, additional, Breyholz, Hans-Jörg, additional, Yeh, Randy, additional, Weigel, Stefanie B., additional, Stichling, Patricia, additional, Heindel, Walter, additional, Bobe, Stefanie, additional, Barth, Peter, additional, Tio, Joke, additional, and Schäfers, Michael, additional

Published
2022
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92. Glutamine prevents acute kidney injury by modulating oxidative stress and apoptosis in tubular epithelial cells

Author

Thomas, Katharina, primary, Zondler, Lisa, additional, Ludwig, Nadine, additional, Kardell, Marina, additional, Lüneburg, Corinna, additional, Henke, Katharina, additional, Mersmann, Sina, additional, Margraf, Andreas, additional, Spieker, Tilmann, additional, Tekath, Tobias, additional, Velic, Ana, additional, Holtmeier, Richard, additional, Hermann, Juliane, additional, Jankowski, Vera, additional, Meersch, Melanie, additional, Vestweber, Dietmar, additional, Westphal, Martin, additional, Roth, Johannes, additional, Schäfers, Michael A., additional, Kellum, John A., additional, Lowell, Clifford A., additional, Rossaint, Jan, additional, and Zarbock, Alexander, additional

Published
2022
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98. Fibroblast Activation Protein Triggers Release of Drug Payload from Non-internalizing Small Molecule Drug Conjugates in Solid Tumors

Author

Zana, Aureliano, primary, Galbiati, Andrea, additional, Gilardoni, Ettore, additional, Bocci, Matilde, additional, Millul, Jacopo, additional, Sturm, Theo, additional, Stucchi, Riccardo, additional, Elsayed, Abdullah, additional, Nadal, Lisa, additional, Cirillo, Martina, additional, Roll, Wolfgang, additional, Stegger, Lars, additional, Asmus, Inga, additional, Backhaus, Philipp, additional, Schäfers, Michael, additional, Neri, Dario, additional, and Cazzamalli, Samuele, additional

Published
2022
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99. Imaging of the calcium activated potassium channel 3.1 (KCa3.1) in vivo using a senicapoc‐derived positron emission tomography tracer

Author

Konken, Christian P., primary, Heßling, Kathrin, additional, Thale, Insa, additional, Schelhaas, Sonja, additional, Dabel, Jennifer, additional, Maskri, Sarah, additional, Bulk, Etmar, additional, Budde, Thomas, additional, Koch, Oliver, additional, Schwab, Albrecht, additional, Schäfers, Michael, additional, and Wünsch, Bernhard, additional

Published
2022
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