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Summary Multilevel inverters are known as essential converters in renewable sources. First, in this paper, a new submodule is presented, and based on it, a new sub‐multilevel inverter is presented. The proposed sub‐multilevel inverter consists of several unidirectional and bidirectional switches and DC voltage sources. Then, the generalized topology, developed in two modular and cascaded modes, is presented to increase production levels. The proposed submodules are connected in series in the modular topology, increasing production levels. The proposed topology to produce the maximum output levels has the minimum number of IGBTs, drivers, DC voltage sources, etc. Mathematical analyses for conduction and switching losses are provided, and mathematical analyses for the number of devices and voltage across the switches are also presented. In addition to the mathematical analysis of losses, the simulation results are also presented. A general comparison of proposed topology components is presented to demonstrate their advantages. This comparison shows that the proposed topology has the minimum number of power electronic devices. In this paper, nearest level modulation is used to control the proposed topology. The simulation and experimental results of the proposed sub‐multilevel verify the performance of the proposed topology. [ABSTRACT FROM AUTHOR]

This paper presents a non‐isolated single‐switch ultra‐high step‐up (UHSU) DC–DC converter with a three‐winding coupled inductor (CI) which is utilized to achieve ultra‐high voltage gain with a small amount of duty cycle leading to low conduction losses of the power switch and higher efficiency. The voltage gain of the suggested UHSU converter is adjusted by two methods: the duty cycle of the power switch and the three‐winding CI turn ratio, therefore enhancing the design flexibility of the suggested converter. Due to the utilization of the passive clamp circuit in the structure of the proposed converter, it is possible to select a power switch with low voltage rated and small ON‐state resistance, further enhancing the converter efficiency. The operation modes are discussed in detail and to clarify the salient features of the proposed converter, a comparison with other configurations is provided. Finally, to accredit the performance of the proposed converter, a 150‐W laboratory archetype with an input and output voltage of 20 and 300 V, respectively, at 50 kHz switching frequency is fabricated. [ABSTRACT FROM AUTHOR]

This paper introduces a new structure of a multi-level inverter (MLI) to generate high-level AC voltages using a low number of switches with a quasi-sine waveform. The small number of driver circuits utilised in bidirectional switches is a salient characteristic of this inverter. Also, the number of conducting switches at each voltage level is low in this structure. This results in lower conduction losses of the switches. The proposed topology can be used as the cascaded structure with different approaches to select the value of voltage sources. Power losses are discussed for the proposed structure. To compare the proposed multi-level inverter and demonstrate its superiority, a comparison has been made with some recently presented topologies. According to the comparison results, the advantage of the proposed structure is producing high voltage levels with a smaller number of switches and driver circuits. To prove the suitable performance of the proposed MLI, a 21-level symmetric and 37-level asymmetric inverter containing 14 switches are designed and simulated in the MATLAB/Simulink program. A laboratory prototype for each of these inverters is implemented. The experimental results finely verify the simulations. Besides, an accurate comparison with recently introduced multilevel inverters has been carried out to confirm the effectiveness and superiority of the proposed structure. [ABSTRACT FROM AUTHOR]

Aneurysmal subarachnoid hemorrhage (aSAH) accounts for 2-5% of all strokes, and 10%-15% of aSAH patients will not survive until hospital admission. Induced hypertension (IH) is an emerging therapeutic option being used for the treatment of vasospasm in aSAH. For patients with cerebral vasospasm (CVS) consequent to SAH, IH is implemented to increase systolic blood pressure (SBP) in order to optimize cerebral blood flow (CBF) and prevent delayed cerebral ischemia (DCI). Prophylactic use of IH has been associated with the development of vasospasm and cerebral ischemia in SAH patients. Various trials have defined several different parameters to help clinicians decide when to initiate IH in a SAH patient. However, there is insufficient evidence to recommend therapeutic IH in aSAH due to the possible serious complications like myocardial ischemia, development of posterior reversible encephalopathy syndrome (PRES), pulmonary edema, and even rupture of another unsecured aneurysm. This narrative review showed the favorable impact of IH therapy on aSAH patients; however, it is crucial to conduct further clinical and molecular experiments to shed more light on the effects of IH in aSAH. [ABSTRACT FROM AUTHOR]