55 results on '"Sell, Erick"'
Search Results
52. Understanding the physical literacy development of 8- to 12-year-old children living with chronic medical conditions: A comprehensive, mixed methods inquiry.
- Author
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Blais A, Katz SL, Klaassen RJ, Lougheed J, Reisman JJ, Pohl D, Lawrence S, Lai L, Lee S, Gardin L, Wong D, Sell E, and Longmuir P
- Subjects
- Humans, Child, Female, Male, Chronic Disease, Canada, Child Development physiology, Qualitative Research, Health Literacy, Exercise psychology
- Abstract
Background: Physical literacy is a concept used to describe the combined physical, affective and cognitive capacities facilitating an active lifestyle. Physical activity participation is essential for children living with chronic medical conditions, but knowledge of physical literacy among this group is scarce., Methods: An explanatory, sequential mixed methods design was used to comprehensively describe the physical literacies of children with chronic medical conditions (CMCs). Participants were recruited from paediatric cardiology, respirology/cystic fibrosis, neurology, haematology and endocrinology outpatient clinics. All participants completed the Canadian Assessment of Physical Literacy (2nd Edition), and those with higher and lower scores were invited to a semi-structured interview. A deductive-inductive thematic analysis was applied using Margaret Whitehead's conceptualization of physical literacy., Results: Using normative strata, 80.0% of the 99 children assessed (mean age = 9.97 ± 1.3 years, 48% girls) were considered beginning or progressing in their overall physical literacy (mean score = 56.5 ± 13.8/100). Meanwhile, physical literacy informed participants' approach to new, active experiences and may have contributed to a strong sense of self. There was a significant difference between endocrinology and haematology patients on total physical literacy score (p = 0.03) but not domain scores. Participants scored high on motivation/confidence (mean = 22.9 ± 5.0/30) but obtained low physical competence (mean = 11.8 ± 5.6/30) and daily behaviour scores (n = 72, mean = 15.5 ± 7.1/30). Main themes represent salient experiences of children with CMCs within the domains of physical literacy, including their need to evaluate active contexts, self-regulate activity intensity and manage physical limitations., Conclusions: Children with CMCs can achieve recommended levels of physical literacy without meeting normative standards for physical competence. Participants would benefit from a physical literacy intervention that targets the development of bodily self-regulation skills and risk evaluation in active settings., (© 2024 The Author(s). Child: Care, Health and Development published by John Wiley & Sons Ltd.)
- Published
- 2024
- Full Text
- View/download PDF
53. Developmental epileptic encephalopathy in DLG4-related synaptopathy.
- Author
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Kassabian B, Levy AM, Gardella E, Aledo-Serrano A, Ananth AL, Brea-Fernández AJ, Caumes R, Chatron N, Dainelli A, De Wachter M, Denommé-Pichon AS, Dye TJ, Fazzi E, Felt R, Fernández-Jaén A, Fernández-Prieto M, Gantz E, Gasperowicz P, Gil-Nagel A, Gómez-Andrés D, Greiner HM, Guerrini R, Haanpää MK, Helin M, Hoyer J, Hurst ACE, Kallish S, Karkare SN, Khan A, Kleinendorst L, Koch J, Kothare SV, Koudijs SM, Lagae L, Lakeman P, Leppig KA, Lesca G, Lopergolo D, Lusk L, Mackenzie A, Mei D, Møller RS, Pereira EM, Platzer K, Quelin C, Revah-Politi A, Rheims S, Rodríguez-Palmero A, Rossi A, Santorelli F, Seinfeld S, Sell E, Stephenson D, Szczaluba K, Trinka E, Umair M, Van Esch H, van Haelst MM, Veenma DCM, Weber S, Weckhuysen S, Zacher P, Tümer Z, and Rubboli G
- Subjects
- Humans, Retrospective Studies, Muscle Hypotonia, Seizures complications, Electroencephalography methods, Disks Large Homolog 4 Protein genetics, Epilepsy diagnostic imaging, Epilepsy genetics, Epilepsy complications, Brain Diseases genetics, Epilepsy, Generalized complications, Intellectual Disability genetics, Intellectual Disability complications
- Abstract
Objective: The postsynaptic density protein of excitatory neurons PSD-95 is encoded by discs large MAGUK scaffold protein 4 (DLG4), de novo pathogenic variants of which lead to DLG4-related synaptopathy. The major clinical features are developmental delay, intellectual disability (ID), hypotonia, sleep disturbances, movement disorders, and epilepsy. Even though epilepsy is present in 50% of the individuals, it has not been investigated in detail. We describe here the phenotypic spectrum of epilepsy and associated comorbidities in patients with DLG4-related synaptopathy., Methods: We included 35 individuals with a DLG4 variant and epilepsy as part of a multicenter study. The DLG4 variants were detected by the referring laboratories. The degree of ID, hypotonia, developmental delay, and motor disturbances were evaluated by the referring clinician. Data on awake and sleep electroencephalography (EEG) and/or video-polygraphy and brain magnetic resonance imaging were collected. Antiseizure medication response was retrospectively assessed by the referring clinician., Results: A large variety of seizure types was reported, although focal seizures were the most common. Encephalopathy related to status epilepticus during slow-wave sleep (ESES)/developmental epileptic encephalopathy with spike-wave activation during sleep (DEE-SWAS) was diagnosed in >25% of the individuals. All but one individual presented with neurodevelopmental delay. Regression in verbal and/or motor domains was observed in all individuals who suffered from ESES/DEE-SWAS, as well as some who did not. We could not identify a clear genotype-phenotype relationship even between individuals with the same DLG4 variants., Significance: Our study shows that a subgroup of individuals with DLG4-related synaptopathy have DEE, and approximately one fourth of them have ESES/DEE-SWAS. Our study confirms DEE as part of the DLG4-related phenotypic spectrum. Occurrence of ESES/DEE-SWAS in DLG4-related synaptopathy requires proper investigation with sleep EEG., (© 2023 International League Against Epilepsy.)
- Published
- 2024
- Full Text
- View/download PDF
54. YouTube videos as a teaching tool and patient resource for infantile spasms.
- Author
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Fat MJ, Doja A, Barrowman N, and Sell E
- Subjects
- Audiovisual Aids standards, Education, Medical, Graduate methods, Education, Medical, Graduate standards, Health Resources trends, Humans, Infant, Infant, Newborn, Patient Education as Topic methods, Physician-Patient Relations, Spasms, Infantile physiopathology, Spasms, Infantile therapy, Teaching Materials standards, Video Recording methods, Video Recording standards, Audiovisual Aids trends, Education, Medical, Graduate trends, Internet trends, Patient Education as Topic trends, Spasms, Infantile diagnosis, Video Recording trends
- Abstract
The purpose of this study was to assess YouTube videos for their efficacy as a patient resource for infantile spasms. Videos were searched using the terms infantile spasm, spasm, epileptic spasm, and West syndrome. The top 25 videos under each term were selected according to set criteria. Technical quality, diagnosis of infantile spasms, and suitability as a teaching resource were assessed by 2 neurologists using the Medical Video Rating Scale. There were 5858 videos found. Of the 100 top videos, 46% did not meet selection criteria. Mean rating for technical quality was 4.0 of 5 for rater 1 and 3.9 of 5 for rater 2. Raters found 60% and 64% of videos to accurately portray infantile spasms, respectively, with significant agreement (Cohen κ coefficient = 0.75, P < .001). Ten videos were considered excellent examples (grading of 5 of 5) by at least 1 rater. YouTube may be used as an excellent patient resource for infantile spasms if guided search practices are followed.
- Published
- 2011
- Full Text
- View/download PDF
55. [Functional magnetic resonance].
- Author
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Sell E
- Subjects
- Electroencephalography, Epilepsy surgery, Humans, Brain Mapping, Epilepsy physiopathology, Magnetic Resonance Imaging, Oxygen blood
- Abstract
Functional magnetic resonance imaging (fmri) is a non-invasive functional brain mapping technique ased on blood oxygenated level dependent signal (BOLD). It is obtained during T2* weighted imaging MRI studies. fmri aids in the localization of language and motor function for patients candidates for epilepsy surgery, and has up to a 90% concordance with WADA test. Even though synchronous recording of fmri and EEG is technically challenging, it shows a discordant pattern of activation when compared with EEG or electrocorticography. This finding could be due to complex epileptic networks, and overall this study technique has the potential to contribute to further research into epileptic network and epilepsy physiopathology.
- Published
- 2007
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