272 results on '"Setiawan, V Wendy"'
Search Results
52. Abstract 1169: Racial/ethnic differences in postmenopausal breast cancer incidence and risk factors: Results from the Multiethnic Cohort (MEC) Study
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Sarink, Danja, primary, Le Marchand, Loic, additional, Loo, Lenora W., additional, Park, Song-Yi, additional, White, Kami K., additional, Setiawan, V Wendy, additional, Wu, Anna H., additional, Wilkens, Lynne R., additional, and Merritt, Melissa A., additional
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- 2020
- Full Text
- View/download PDF
53. Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer
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Kho, Pik‐Fang, primary, Amant, Frederic, additional, Annibali, Daniela, additional, Ashton, Katie, additional, Attia, John, additional, Auer, Paul L., additional, Beckmann, Matthias W., additional, Black, Amanda, additional, Brinton, Louise, additional, Buchanan, Daniel D., additional, Chanock, Stephen J., additional, Chen, Chu, additional, Chen, Maxine M., additional, Cheng, Timothy H. T., additional, Cook, Linda S., additional, Crous‐Bous, Marta, additional, Czene, Kamila, additional, De Vivo, Immaculata, additional, Dennis, Joe, additional, Dörk, Thilo, additional, Dowdy, Sean C., additional, Dunning, Alison M., additional, Dürst, Matthias, additional, Easton, Douglas F., additional, Ekici, Arif B., additional, Fasching, Peter A., additional, Fridley, Brooke L., additional, Friedenreich, Christine M., additional, García‐Closas, Montserrat, additional, Gaudet, Mia M., additional, Giles, Graham G., additional, Goode, Ellen L., additional, Gorman, Maggie, additional, Haiman, Christopher A., additional, Hall, Per, additional, Hankinson, Susan E., additional, Hein, Alexander, additional, Hillemanns, Peter, additional, Hodgson, Shirley, additional, Hoivik, Erling A., additional, Holliday, Elizabeth G., additional, Hunter, David J., additional, Jones, Angela, additional, Kraft, Peter, additional, Krakstad, Camilla, additional, Lambrechts, Diether, additional, Le Marchand, Loic, additional, Liang, Xiaolin, additional, Lindblom, Annika, additional, Lissowska, Jolanta, additional, Long, Jirong, additional, Lu, Lingeng, additional, Magliocco, Anthony M., additional, Martin, Lynn, additional, McEvoy, Mark, additional, Milne, Roger L., additional, Mints, Miriam, additional, Nassir, Rami, additional, Otton, Geoffrey, additional, Palles, Claire, additional, Pooler, Loreall, additional, Proietto, Tony, additional, Rebbeck, Timothy R., additional, Renner, Stefan P., additional, Risch, Harvey A., additional, Rübner, Matthias, additional, Runnebaum, Ingo, additional, Sacerdote, Carlotta, additional, Sarto, Gloria E., additional, Schumacher, Fredrick, additional, Scott, Rodney J., additional, Setiawan, V. Wendy, additional, Shah, Mitul, additional, Sheng, Xin, additional, Shu, Xiao‐Ou, additional, Southey, Melissa C., additional, Tham, Emma, additional, Tomlinson, Ian, additional, Trovik, Jone, additional, Turman, Constance, additional, Tyrer, Jonathan P., additional, Van Den Berg, David, additional, Wang, Zhaoming, additional, Wentzensen, Nicolas, additional, Xia, Lucy, additional, Xiang, Yong‐Bing, additional, Yang, Hannah P., additional, Yu, Herbert, additional, Zheng, Wei, additional, Webb, Penelope M., additional, Thompson, Deborah J., additional, Spurdle, Amanda B., additional, Glubb, Dylan M., additional, and O'Mara, Tracy A., additional
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- 2020
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54. Increased hepatic and circulating chemokine and osteopontin expression occurs early in human NAFLD development
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Kriss, Michael, primary, Golden-Mason, Lucy, additional, Kaplan, Jeffrey, additional, Mirshahi, Faridoddin, additional, Setiawan, V. Wendy, additional, Sanyal, Arun J., additional, and Rosen, Hugo R., additional
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- 2020
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55. Abstract B41: Racial/ethnic disparities in epithelial ovarian cancer and its risk factors: The Multiethnic Cohort Study
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Sarink, Danja, primary, Park, Song Yi, additional, Le Marchand, Loic, additional, White, Kami, additional, Hernandez, Brenda, additional, Wilkens, Lynne, additional, Setiawan, V. Wendy, additional, Wu, Anna, additional, and Merritt, Melissa A., additional
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- 2020
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56. Genome‐Wide Association Study of Liver Fat: The Multiethnic Cohort Adiposity Phenotype Study
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Park, S. Lani, primary, Li, Yuqing, additional, Sheng, Xin, additional, Hom, Victor, additional, Xia, Lucy, additional, Zhao, Kechen, additional, Pooler, Loreall, additional, Setiawan, V. Wendy, additional, Lim, Unhee, additional, Monroe, Kristine R., additional, Wilkens, Lynne R., additional, Kristal, Bruce S., additional, Lampe, Johanna W., additional, Hullar, Meredith, additional, Shepherd, John, additional, Loo, Lenora L. M., additional, Ernst, Thomas, additional, Franke, Adrian A., additional, Tiirikainen, Maarit, additional, Haiman, Christopher A., additional, Stram, Daniel O., additional, Le Marchand, Loïc, additional, and Cheng, Iona, additional
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- 2020
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57. Abstract C071: Racial/ethnic disparities in weight, weight change in adulthood, and pancreatic cancer incidence: The Multiethnic Cohort
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Farias, Albert J, primary, Stram, Daniel O, additional, Wang, Songren, additional, Pandol, Stephen J, additional, Monroe, Kristine R, additional, and Setiawan, V. Wendy, additional
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- 2020
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58. Abstract C096: Ethnic differences of chronic obstructive pulmonary disease (COPD) in the Multiethnic Cohort study
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Park, Sungshim L., primary, Cheng, Iona, additional, Wu, Anna H., additional, Porcel, Jackie, additional, Wilkens, Lynne R., additional, Marchand, Loic Le, additional, and Setiawan, V. Wendy, additional
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- 2020
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59. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium†
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Canzian, Federico, Cox, David G., Setiawan, V. Wendy, Stram, Daniel O., Ziegler, Regina G., Dossus, Laure, Beckmann, Lars, Blanché, Hélène, Barricarte, Aurelio, Berg, Christine D., Bingham, Sheila, Buring, Julie, Buys, Saundra S., Calle, Eugenia E., Chanock, Stephen J., Clavel-Chapelon, Françoise, DeLancey, John Oliver, Diver, W. Ryan, Dorronsoro, Miren, Haiman, Christopher A., Hallmans, Göran, Hankinson, Susan E., Hunter, David J., Hüsing, Anika, Isaacs, Claudine, Khaw, Kay-Tee, Kolonel, Laurence N., Kraft, Peter, Le Marchand, Loïc, Lund, Eiliv, Overvad, Kim, Panico, Salvatore, Peeters, Petra H.M., Pollak, Michael, Thun, Michael J., Tjønneland, Anne, Trichopoulos, Dimitrios, Tumino, Rosario, Yeager, Meredith, Hoover, Robert N., Riboli, Elio, Thomas, Gilles, Henderson, Brian E., Kaaks, Rudolf, and Feigelson, Heather Spencer
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- 2010
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60. Genetic variation in the progesterone receptor gene and risk of endometrial cancer: a haplotype-based approach
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Lee, Eunjung, Hsu, Chris, Haiman, Christopher A., Razavi, Pedram, Horn-Ross, Pamela L., Van Den Berg, David, Bernstein, Leslie, Le Marchand, Loic, Henderson, Brian E., Setiawan, V. Wendy, and Ursin, Giske
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- 2010
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61. Circulating 25-Hydroxyvitamin D and Risk of Kidney Cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers
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Gallicchio, Lisa, Moore, Lee E., Stevens, Victoria L., Ahn, Jiyoung, Albanes, Demetrius, Hartmuller, Virginia, Setiawan, V. Wendy, Helzlsouer, Kathy J., Yang, Gong, Xiang, Yong-Bing, Shu, Xiao-Ou, Snyder, Kirk, Weinstein, Stephanie J., Yu, Kai, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Cai, Qiuyin, Campbell, David S., Chen, Yu, Chow, Wong-Ho, Horst, Ronald L., Kolonel, Laurence N., McCullough, Marjorie L., Purdue, Mark P., and Koenig, Karen L.
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- 2010
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62. Circulating 25-Hydroxyvitamin D and Risk of Endometrial Cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers
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Zeleniuch-Jacquotte, Anne, Gallicchio, Lisa, Hartmuller, Virginia, Helzlsouer, Kathy J., McCullough, Marjorie L., Setiawan, V. Wendy, Shu, Xiao-Ou, Weinstein, Stephanie J., Weiss, Jocelyn M., Arslan, Alan A., De Vivo, Immaculata, Gao, Yu-Tang, Hayes, Richard B., Henderson, Brian E., Horst, Ronald L., Koenig, Karen L., Patel, Alpa V., Purdue, Mark P., Snyder, Kirk, Steplowski, Emily, Yu, Kai, Zheng, Wei, and Hankinson, Susan E.
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- 2010
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63. Racial/ethnic differences in postmenopausal breast cancer risk by hormone receptor status: The multiethnic cohort study.
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Sarink, Danja, White, Kami K., Loo, Lenora W.M., Wu, Anna H., Wilkens, Lynne R., Le Marchand, Loïc, Park, Song‐Yi, Setiawan, V. Wendy, and Merritt, Melissa A.
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BREAST cancer ,HORMONE receptor positive breast cancer ,DISEASE risk factors ,ETHNIC differences ,HORMONE receptors - Abstract
There are racial/ethnic differences in the incidence of hormone receptor positive and negative breast cancer. To understand why these differences exist, we investigated associations between hormone‐related factors and breast cancer risk by race/ethnicity in the Multiethnic Cohort (MEC) Study. Among 81 511 MEC participants (Native Hawaiian, Japanese American, Latina, African American and White women), 3806 estrogen receptor positive (ER+) and 828 ER− incident invasive breast cancers were diagnosed during a median of 21 years of follow‐up. We used Cox proportional hazards regression models to calculate associations between race/ethnicity and breast cancer risk, and associations between hormone‐related factors and breast cancer risk by race/ethnicity. Relative to White women, ER+ breast cancer risk was higher in Native Hawaiians and lower in Latinas and African Americans; ER− disease risk was higher in African Americans. We observed interaction with race/ethnicity in associations between oral contraceptive use (OC; Pint.03) and body mass index (BMI; Pint.05) with ER+ disease risk; ever versus never OC use increased risk only in Latinas and positive associations for obese versus lean BMI were strongest in Japanese Americans. For ER‐ disease risk, associations for OC use, particularly duration of use, were strongest for African Americans (Pint.04). Our study shows that associations of OC use and obesity with ER+ and ER− breast cancer risk differ by race/ethnicity, but established risk factors do not fully explain racial/ethnic differences in risk. Further studies are needed to identify factors to explain observed racial/ethnic differences in breast cancer incidence. What's new? Racial/ethnic differences in hormone receptor positive and negative breast cancer risk are well‐documented; the factors contributing to these differences less so. The authors compared hormone‐related risk factors for breast cancer among a multiethnic population. They identified a number of notable differences in the impact of established risk factors ‐ particularly oral contraceptive use and BMI ‐ between racial/ethnic groups. These results reinforce the need to consider race/ethnicity in breast cancer studies and prevention recommendations. [ABSTRACT FROM AUTHOR]
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- 2022
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64. Ovarian cancer risk factors by tumor aggressiveness: An analysis from the Ovarian Cancer Cohort Consortium
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Fortner, Renee T. Poole, Elizabeth M. Wentzensen, Nicolas A. and Trabert, Britton White, Emily Arslan, Alan A. Patel, V, Alpa and Setiawan, V. Wendy Visvanathan, Kala Weiderpass, Elisabete and Adami, Hans-Olov Black, Amanda Bernstein, Leslie and Brinton, Louise A. Buring, Julie Clendenen, V, Tess and Fournier, Agnes Fraser, Gary Gapstur, Susan M. Gaudet, Mia M. Giles, Graham G. Gram, Inger T. Hartge, Patricia and Hoffman-Bolton, Judith Idahl, Annika Kaaks, Rudolf Kirsh, Victoria A. Knutsen, Synnove Koh, Woon-Puay Lacey, Jr., James V. Lee, I-Min Lundin, Eva Merritt, Melissa A. and Milne, Roger L. Onland-Moret, N. Charlotte Peters, Ulrike and Poynter, Jenny N. Rinaldi, Sabina Robien, Kim Rohan, Thomas and Sanchez, Maria-Jose Schairer, Catherine Schouten, Leo J. and Tjonneland, Anne Townsend, Mary K. Travis, Ruth C. and Trichopoulou, Antonia van den Brandt, Piet A. Vineis, Paolo and Wilkens, Lynne Wolk, Alicja Yang, Hannah P. and Zeleniuch-Jacquotte, Anne Tworoger, Shelley S.
- Abstract
Ovarian cancer risk factors differ by histotype; however, within subtype, there is substantial variability in outcomes. We hypothesized that risk factor profiles may influence tumor aggressiveness, defined by time between diagnosis and death, independent of histology. Among 1.3 million women from 21 prospective cohorts, 4,584 invasive epithelial ovarian cancers were identified and classified as highly aggressive (death in = 35 vs. 20 to < 25 kg/m(2), 1.93 [1.46-2.56] and current smoking (vs. never, 1.30 [1.07-1.57]) were associated with increased risk of highly aggressive disease. Results were similar within histotypes. Ovarian cancer risk factors may be directly associated with subtypes defined by tumor aggressiveness, rather than through differential effects on histology. Studies to assess biological pathways are warranted.
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- 2019
65. Publisher Correction: Shared heritability and functional enrichment across six solid cancers (Nature Communications, (2019), 10, 1, (431), 10.1038/s41467-018-08054-4)
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Jiang, Xia, Finucane, Hilary K., Schumacher, Fredrick R., Schmit, Stephanie L., Tyrer, Jonathan P., Han, Younghun, Michailidou, Kyriaki, Lesseur, Corina, Kuchenbaecker, Karoline B., Dennis, Joe, Conti, David V., Casey, Graham, Gaudet, Mia M., Huyghe, Jeroen R., Albanes, Demetrius, Aldrich, Melinda C., Andrew, Angeline S., Andrulis, Irene L., Anton-Culver, Hoda, Antoniou, Antonis C., Antonenkova, Natalia N., Arnold, Susanne M., Aronson, Kristan J., Arun, Banu K., Bandera, Elisa V., Barkardottir, Rosa B., Barnes, Daniel R., Batra, Jyotsna, Beckmann, Matthias W., Benitez, Javier, Benlloch, Sara, Berchuck, Andrew, Berndt, Sonja I., Bickeböller, Heike, Bien, Stephanie A., Blomqvist, Carl, Boccia, Stefania, Bogdanova, Natalia V., Bojesen, Stig E., Bolla, Manjeet K., Brauch, Hiltrud, Brenner, Hermann, Brenton, James D., Brook, Mark N., Brunet, Joan, Brunnström, Hans, Buchanan, Daniel D., Burwinkel, Barbara, Butzow, Ralf, Cadoni, Gabriella, Caldés, Trinidad, Caligo, Maria A., Campbell, Ian, Campbell, Peter T., Cancel-Tassin, Géraldine, Cannon-Albright, Lisa, Campa, Daniele, Caporaso, Neil, Carvalho, André L., Chan, Andrew T., Chang-Claude, Jenny, Chanock, Stephen J., Chen, Chu, Christiani, David C., Claes, Kathleen B.M., Claessens, Frank, Clements, Judith, Collée, J. Margriet, Correa, Marcia Cruz, Couch, Fergus J., Cox, Angela, Cunningham, Julie M., Cybulski, Cezary, Czene, Kamila, Daly, Mary B., deFazio, Anna, Devilee, Peter, Diez, Orland, Gago-Dominguez, Manuela, Donovan, Jenny L., Dörk, Thilo, Duell, Eric J., Dunning, Alison M., Dwek, Miriam, Eccles, Diana M., Edlund, Christopher K., Edwards, Digna R.Velez, Ellberg, Carolina, Evans, D. Gareth, Fasching, Peter A., Ferris, Robert L., Liloglou, Triantafillos, Figueiredo, Jane C., Fletcher, Olivia, Fortner, Renée T., Fostira, Florentia, Franceschi, Silvia, Friedman, Eitan, Gallinger, Steven J., Ganz, Patricia A., Garber, Judy, García-Sáenz, José A., Gayther, Simon A., Giles, Graham G., Godwin, Andrew K., Goldberg, Mark S., Goldgar, David E., Goode, Ellen L., Goodman, Marc T., Goodman, Gary, Grankvist, Kjell, Greene, Mark H., Gronberg, Henrik, Gronwald, Jacek, Guénel, Pascal, Håkansson, Niclas, Hall, Per, Hamann, Ute, Hamdy, Freddie C., Hamilton, Robert J., Hampe, Jochen, Haugen, Aage, Heitz, Florian, Herrero, Rolando, Hillemanns, Peter, Hoffmeister, Michael, Høgdall, Estrid, Hong, Yun Chul, Hopper, John L., Houlston, Richard, Hulick, Peter J., Hunter, David J., Huntsman, David G., Idos, Gregory, Imyanitov, Evgeny N., Ingles, Sue Ann, Isaacs, Claudine, Jakubowska, Anna, James, Paul, Jenkins, Mark A., Johansson, Mattias, Johansson, Mikael, John, Esther M., Joshi, Amit D., Kaneva, Radka, Karlan, Beth Y., Kelemen, Linda E., Kühl, Tabea, Khaw, Kay Tee, Khusnutdinova, Elza, Kibel, Adam S., Kiemeney, Lambertus A., Kim, Jeri, Kjaer, Susanne K., Knight, Julia A., Kogevinas, Manolis, Kote-Jarai, Zsofia, Koutros, Stella, Kristensen, Vessela N., Kupryjanczyk, Jolanta, Lacko, Martin, Lam, Stephan, Lambrechts, Diether, Landi, Maria Teresa, Lazarus, Philip, Le, Nhu D., Lee, Eunjung, Lejbkowicz, Flavio, Lenz, Heinz Josef, Leslie, Goska, Lessel, Davor, Lester, Jenny, Levine, Douglas A., Li, Li, Li, Christopher I., Lindblom, Annika, Lindor, Noralane M., Liu, Geoffrey, Loupakis, Fotios, Lubiński, Jan, Maehle, Lovise, Maier, Christiane, Mannermaa, Arto, Marchand, Loic Le, Margolin, Sara, May, Taymaa, McGuffog, Lesley, Meindl, Alfons, Middha, Pooja, Miller, Austin, Milne, Roger L., MacInnis, Robert J., Modugno, Francesmary, Montagna, Marco, Moreno, Victor, Moysich, Kirsten B., Mucci, Lorelei, Muir, Kenneth, Mulligan, Anna Marie, Nathanson, Katherine L., Neal, David E., Ness, Andrew R., Neuhausen, Susan L., Nevanlinna, Heli, Newcomb, Polly A., Newcomb, Lisa F., Nielsen, Finn Cilius, Nikitina-Zake, Liene, Nordestgaard, Børge G., Nussbaum, Robert L., Offit, Kenneth, Olah, Edith, Olama, Ali Amin Al, Olopade, Olufunmilayo I., Olshan, Andrew F., Olsson, Håkan, Osorio, Ana, Pandha, Hardev, Park, Jong Y., Pashayan, Nora, Parsons, Michael T., Pejovic, Tanja, Penney, Kathryn L., Peters, Wilbert H.M., Phelan, Catherine M., Phipps, Amanda I., Plaseska-Karanfilska, Dijana, Pring, Miranda, Prokofyeva, Darya, Radice, Paolo, Stefansson, Kari, Ramus, Susan J., Raskin, Leon, Rennert, Gad, Rennert, Hedy S., van Rensburg, Elizabeth J., Riggan, Marjorie J., Risch, Harvey A., Risch, Angela, Roobol, Monique J., Rosenstein, Barry S., Rossing, Mary Anne, De Ruyck, Kim, Saloustros, Emmanouil, Sandler, Dale P., Sawyer, Elinor J., Schabath, Matthew B., Schleutker, Johanna, Schmidt, Marjanka K., Setiawan, V. Wendy, Shen, Hongbing, Siegel, Erin M., Sieh, Weiva, Singer, Christian F., Slattery, Martha L., Sorensen, Karina Dalsgaard, Southey, Melissa C., Spurdle, Amanda B., Stanford, Janet L., Stevens, Victoria L., Stintzing, Sebastian, Stone, Jennifer, Sundfeldt, Karin, Sutphen, Rebecca, Swerdlow, Anthony J., Tajara, Eloiza H., Tangen, Catherine M., Tardon, Adonina, Taylor, Jack A., Teare, M. Dawn, Teixeira, Manuel R., Terry, Mary Beth, Terry, Kathryn L., Thibodeau, Stephen N., Thomassen, Mads, Bjørge, Line, Tischkowitz, Marc, Toland, Amanda E., Torres, Diana, Townsend, Paul A., Travis, Ruth C., Tung, Nadine, Tworoger, Shelley S., Ulrich, Cornelia M., Usmani, Nawaid, Vachon, Celine M., Van Nieuwenhuysen, Els, Vega, Ana, Aguado-Barrera, Miguel Elías, Wang, Qin, Webb, Penelope M., Weinberg, Clarice R., Weinstein, Stephanie, Weissler, Mark C., Weitzel, Jeffrey N., West, Catharine M.L., White, Emily, Whittemore, Alice S., Wichmann, H. Erich, Wiklund, Fredrik, Winqvist, Robert, Wolk, Alicja, Woll, Penella, Woods, Michael, Wu, Anna H., Wu, Xifeng, Yannoukakos, Drakoulis, Zheng, Wei, Zienolddiny, Shanbeh, Ziogas, Argyrios, Zorn, Kristin K., Lane, Jacqueline M., Saxena, Richa, Thomas, Duncan, Hung, Rayjean J., Diergaarde, Brenda, McKay, James, Peters, Ulrike, Hsu, Li, García-Closas, Montserrat, Eeles, Rosalind A., Chenevix-Trench, Georgia, Brennan, Paul J., Haiman, Christopher A., Simard, Jacques, Easton, Douglas F., Gruber, Stephen B., Pharoah, Paul D.P., Price, Alkes L., Pasaniuc, Bogdan, Amos, Christopher I., Kraft, Peter, and Lindström, Sara
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head and neck ,Settore MED/31 - OTORINOLARINGOIATRIA - Abstract
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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- 2019
66. Ovarian cancer risk factors by tumor aggressiveness : An analysis from the Ovarian Cancer Cohort Consortium
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Fortner, Renée T., Poole, Elizabeth M., Wentzensen, Nicolas A., Trabert, Britton, White, Emily, Arslan, Alan A., Patel, Alpa V., Setiawan, V. Wendy, Visvanathan, Kala, Weiderpass, Elisabete, Adami, Hans-Olov, Black, Amanda, Bernstein, Leslie, Brinton, Louise A., Buring, Julie, Clendenen, Tess V., Fournier, Agnès, Fraser, Gary, Gapstur, Susan M., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Hartge, Patricia, Hoffman-Bolton, Judith, Idahl, Annika, Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove, Koh, Woon-Puay, Lacey, James V., Lee, I-Min, Lundin, Eva, Merritt, Melissa A., Milne, Roger L., Onland-Moret, N. Charlotte, Peters, Ulrike, Poynter, Jenny N., Rinaldi, Sabina, Robien, Kim, Rohan, Thomas, Sánchez, Maria-José, Schairer, Catherine, Schouten, Leo J., Tjonneland, Anne, Townsend, Mary K., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Vineis, Paolo, Wilkens, Lynne, Wolk, Alicja, Yang, Hannah P., Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S., Fortner, Renée T., Poole, Elizabeth M., Wentzensen, Nicolas A., Trabert, Britton, White, Emily, Arslan, Alan A., Patel, Alpa V., Setiawan, V. Wendy, Visvanathan, Kala, Weiderpass, Elisabete, Adami, Hans-Olov, Black, Amanda, Bernstein, Leslie, Brinton, Louise A., Buring, Julie, Clendenen, Tess V., Fournier, Agnès, Fraser, Gary, Gapstur, Susan M., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Hartge, Patricia, Hoffman-Bolton, Judith, Idahl, Annika, Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove, Koh, Woon-Puay, Lacey, James V., Lee, I-Min, Lundin, Eva, Merritt, Melissa A., Milne, Roger L., Onland-Moret, N. Charlotte, Peters, Ulrike, Poynter, Jenny N., Rinaldi, Sabina, Robien, Kim, Rohan, Thomas, Sánchez, Maria-José, Schairer, Catherine, Schouten, Leo J., Tjonneland, Anne, Townsend, Mary K., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Vineis, Paolo, Wilkens, Lynne, Wolk, Alicja, Yang, Hannah P., Zeleniuch-Jacquotte, Anne, and Tworoger, Shelley S.
- Abstract
Ovarian cancer risk factors differ by histotype; however, within subtype, there is substantial variability in outcomes. We hypothesized that risk factor profiles may influence tumor aggressiveness, defined by time between diagnosis and death, independent of histology. Among 1.3 million women from 21 prospective cohorts, 4,584 invasive epithelial ovarian cancers were identified and classified as highly aggressive (death in <1 year, n = 864), very aggressive (death in 1 to < 3 years, n = 1,390), moderately aggressive (death in 3 to < 5 years, n = 639), and less aggressive (lived 5+ years, n = 1,691). Using competing risks Cox proportional hazards regression, we assessed heterogeneity of associations by tumor aggressiveness for all cases and among serous and endometrioid/clear cell tumors. Associations between parity (phet = 0.01), family history of ovarian cancer (phet = 0.02), body mass index (BMI; phet ≤ 0.04) and smoking (phet < 0.01) and ovarian cancer risk differed by aggressiveness. A first/single pregnancy, relative to nulliparity, was inversely associated with highly aggressive disease (HR: 0.72; 95% CI [0.58-0.88]), no association was observed for subsequent pregnancies (per pregnancy, 0.97 [0.92-1.02]). In contrast, first and subsequent pregnancies were similarly associated with less aggressive disease (0.87 for both). Family history of ovarian cancer was only associated with risk of less aggressive disease (1.94 [1.47-2.55]). High BMI (≥35 vs. 20 to < 25 kg/m2 , 1.93 [1.46-2.56] and current smoking (vs. never, 1.30 [1.07-1.57]) were associated with increased risk of highly aggressive disease. Results were similar within histotypes. Ovarian cancer risk factors may be directly associated with subtypes defined by tumor aggressiveness, rather than through differential effects on histology. Studies to assess biological pathways are warranted.
- Published
- 2019
- Full Text
- View/download PDF
67. Racial Differences in Population Attributable Risk for Epithelial Ovarian Cancer in the OCWAA Consortium.
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Peres, Lauren C, Bethea, Traci N, Camacho, Tareq F, Bandera, Elisa V, Beeghly-Fadiel, Alicia, Chyn, Deanna L, Harris, Holly R, Joslin, Charlotte E, Moorman, Patricia G, Myers, Evan, Ochs-Balcom, Heather M, Rosenow, Will, Setiawan, V Wendy, Wu, Anna H, Rosenberg, Lynn, and Schildkraut, Joellen M
- Subjects
OVARIAN epithelial cancer ,OVARIAN cancer ,RACIAL differences ,BREAST cancer ,FALSE discovery rate ,DISEASE risk factors ,RACIAL inequality - Abstract
Background: The causes of racial disparities in epithelial ovarian cancer (EOC) incidence remain unclear. Differences in the prevalence of ovarian cancer risk factors may explain disparities in EOC incidence among African American (AA) and White women.Methods: We used data from 4 case-control studies and 3 case-control studies nested within prospective cohorts in the Ovarian Cancer in Women of African Ancestry Consortium to estimate race-specific associations of 10 known or suspected EOC risk factors using logistic regression. Using the Bruzzi method, race-specific population attributable risks (PAR) were estimated for each risk factor individually and collectively, including groupings of exposures (reproductive factors and modifiable factors). All statistical tests were 2-sided.Results: Among 3244 White EOC cases and 9638 controls and 1052 AA EOC cases and 2410 controls, AA women had a statistically significantly higher PAR (false discovery rate [FDR] P < .001) for first-degree family history of breast cancer (PAR = 10.1%, 95% confidence interval [CI] = 6.5% to 13.7%) compared with White women (PAR = 2.6%, 95% CI = 0.8% to 4.4%). After multiple test correction, AA women had a higher PAR than White women when evaluating all risk factors collectively (PAR = 61.6%, 95% CI = 48.6% to 71.3% vs PAR = 43.0%, 95% CI = 32.8% to 51.4%, respectively; FDR P = .06) and for modifiable exposures, including body mass index, oral contraceptives, aspirin, and body powder (PAR = 36.0%, 95% CI = 21.0% to 48.8% vs PAR = 13.8%, 95% CI = 4.5% to 21.8%, respectively; FDR P = .04).Conclusions: Collectively, the selected risk factors accounted for slightly more of the risk among AA than White women, and interventions to reduce EOC incidence that are focused on multiple modifiable risk factors may be slightly more beneficial to AA women than White women at risk for EOC. [ABSTRACT FROM AUTHOR]- Published
- 2021
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68. Genetics of Chronic Kidney Disease Stages Across Ancestries: The PAGE Study
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Lin, Bridget M., primary, Nadkarni, Girish N., additional, Tao, Ran, additional, Graff, Mariaelisa, additional, Fornage, Myriam, additional, Buyske, Steven, additional, Matise, Tara C., additional, Highland, Heather M., additional, Wilkens, Lynne R., additional, Carlson, Christopher S., additional, Park, S. Lani, additional, Setiawan, V. Wendy, additional, Ambite, Jose Luis, additional, Heiss, Gerardo, additional, Boerwinkle, Eric, additional, Lin, Dan-Yu, additional, Morris, Andrew P., additional, Loos, Ruth J. F., additional, Kooperberg, Charles, additional, North, Kari E., additional, Wassel, Christina L., additional, and Franceschini, Nora, additional
- Published
- 2019
- Full Text
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69. Ovarian cancer risk factors by tumor aggressiveness: An analysis from the Ovarian Cancer Cohort Consortium
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Fortner, Renée T., primary, Poole, Elizabeth M., additional, Wentzensen, Nicolas A., additional, Trabert, Britton, additional, White, Emily, additional, Arslan, Alan A., additional, Patel, Alpa V., additional, Setiawan, V. Wendy, additional, Visvanathan, Kala, additional, Weiderpass, Elisabete, additional, Adami, Hans‐Olov, additional, Black, Amanda, additional, Bernstein, Leslie, additional, Brinton, Louise A., additional, Buring, Julie, additional, Clendenen, Tess V., additional, Fournier, Agnès, additional, Fraser, Gary, additional, Gapstur, Susan M., additional, Gaudet, Mia M., additional, Giles, Graham G., additional, Gram, Inger T., additional, Hartge, Patricia, additional, Hoffman‐Bolton, Judith, additional, Idahl, Annika, additional, Kaaks, Rudolf, additional, Kirsh, Victoria A., additional, Knutsen, Synnove, additional, Koh, Woon‐Puay, additional, Lacey, James V., additional, Lee, I‐Min, additional, Lundin, Eva, additional, Merritt, Melissa A., additional, Milne, Roger L., additional, Onland‐Moret, N. Charlotte, additional, Peters, Ulrike, additional, Poynter, Jenny N., additional, Rinaldi, Sabina, additional, Robien, Kim, additional, Rohan, Thomas, additional, Sánchez, Maria‐José, additional, Schairer, Catherine, additional, Schouten, Leo J., additional, Tjonneland, Anne, additional, Townsend, Mary K., additional, Travis, Ruth C., additional, Trichopoulou, Antonia, additional, Brandt, Piet A., additional, Vineis, Paolo, additional, Wilkens, Lynne, additional, Wolk, Alicja, additional, Yang, Hannah P., additional, Zeleniuch‐Jacquotte, Anne, additional, and Tworoger, Shelley S., additional
- Published
- 2019
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70. Identification of nine new susceptibility loci for endometrial cancer.
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O'Mara, Tracy A, Glubb, Dylan M, Amant, Frederic, Annibali, Daniela, Ashton, Katie, Attia, John, Auer, Paul L, Beckmann, Matthias W, Black, Amanda, Bolla, Manjeet K, Brauch, Hiltrud, Brenner, Hermann, Brinton, Louise, Buchanan, Daniel D, Burwinkel, Barbara, Chang-Claude, Jenny, Chanock, Stephen J, Chen, Chu, Chen, Maxine M, Cheng, Timothy H T, Clarke, Christine L, Clendenning, Mark, Cook, Linda S, Couch, Fergus J, Cox, Angela, Crous-Bous, Marta, Czene, Kamila, Day, Felix, Dennis, Joe, Depreeuw, Jeroen, Doherty, Jennifer Anne, Dörk, Thilo, Dowdy, Sean C, Dürst, Matthias, Ekici, Arif B, Fasching, Peter A, Fridley, Brooke L, Friedenreich, Christine M, Fritschi, Lin, Fung, Jenny, García-Closas, Montserrat, Gaudet, Mia M, Giles, Graham G, Goode, Ellen L, Gorman, Maggie, Haiman, Christopher A, Hall, Per, Hankison, Susan E, Healey, Catherine S, Hein, Alexander, Hillemanns, Peter, Hodgson, Shirley, Hoivik, Erling A, Holliday, Elizabeth G, Hopper, John L, Hunter, David J, Jones, Angela, Krakstad, Camilla, Kristensen, Vessela N, Lambrechts, Diether, Marchand, Loic Le, Liang, Xiaolin, Lindblom, Annika, Lissowska, Jolanta, Long, Jirong, Lu, Lingeng, Magliocco, Anthony M, Martin, Lynn, McEvoy, Mark, Meindl, Alfons, Michailidou, Kyriaki, Milne, Roger L, Mints, Miriam, Montgomery, Grant W, Nassir, Rami, Olsson, Håkan, Orlow, Irene, Otton, Geoffrey, Palles, Claire, Perry, John R B, Peto, Julian, Pooler, Loreall, Prescott, Jennifer, Proietto, Tony, Rebbeck, Timothy R, Risch, Harvey A, Rogers, Peter A W, Rübner, Matthias, Runnebaum, Ingo, Sacerdote, Carlotta, Sarto, Gloria E, Schumacher, Fredrick, Scott, Rodney J, Setiawan, V Wendy, Shah, Mitul, Sheng, Xin, Shu, Xiao-Ou, Southey, Melissa C, Swerdlow, Anthony J, Tham, Emma, Trovik, Jone, Turman, Constance, Tyrer, Jonathan P, Vachon, Celine, VanDen Berg, David, Vanderstichele, Adriaan, Wang, Zhaoming, Webb, Penelope M, Wentzensen, Nicolas, Werner, Henrica M J, Winham, Stacey J, Wolk, Alicja, Xia, Lucy, Xiang, Yong-Bing, Yang, Hannah P, Yu, Herbert, Zheng, Wei, Pharoah, Paul D P, Dunning, Alison M, Kraft, Peter, De Vivo, Immaculata, Tomlinson, Ian, Easton, Douglas F, Spurdle, Amanda B, Thompson, Deborah J, O'Mara, Tracy A, Glubb, Dylan M, Amant, Frederic, Annibali, Daniela, Ashton, Katie, Attia, John, Auer, Paul L, Beckmann, Matthias W, Black, Amanda, Bolla, Manjeet K, Brauch, Hiltrud, Brenner, Hermann, Brinton, Louise, Buchanan, Daniel D, Burwinkel, Barbara, Chang-Claude, Jenny, Chanock, Stephen J, Chen, Chu, Chen, Maxine M, Cheng, Timothy H T, Clarke, Christine L, Clendenning, Mark, Cook, Linda S, Couch, Fergus J, Cox, Angela, Crous-Bous, Marta, Czene, Kamila, Day, Felix, Dennis, Joe, Depreeuw, Jeroen, Doherty, Jennifer Anne, Dörk, Thilo, Dowdy, Sean C, Dürst, Matthias, Ekici, Arif B, Fasching, Peter A, Fridley, Brooke L, Friedenreich, Christine M, Fritschi, Lin, Fung, Jenny, García-Closas, Montserrat, Gaudet, Mia M, Giles, Graham G, Goode, Ellen L, Gorman, Maggie, Haiman, Christopher A, Hall, Per, Hankison, Susan E, Healey, Catherine S, Hein, Alexander, Hillemanns, Peter, Hodgson, Shirley, Hoivik, Erling A, Holliday, Elizabeth G, Hopper, John L, Hunter, David J, Jones, Angela, Krakstad, Camilla, Kristensen, Vessela N, Lambrechts, Diether, Marchand, Loic Le, Liang, Xiaolin, Lindblom, Annika, Lissowska, Jolanta, Long, Jirong, Lu, Lingeng, Magliocco, Anthony M, Martin, Lynn, McEvoy, Mark, Meindl, Alfons, Michailidou, Kyriaki, Milne, Roger L, Mints, Miriam, Montgomery, Grant W, Nassir, Rami, Olsson, Håkan, Orlow, Irene, Otton, Geoffrey, Palles, Claire, Perry, John R B, Peto, Julian, Pooler, Loreall, Prescott, Jennifer, Proietto, Tony, Rebbeck, Timothy R, Risch, Harvey A, Rogers, Peter A W, Rübner, Matthias, Runnebaum, Ingo, Sacerdote, Carlotta, Sarto, Gloria E, Schumacher, Fredrick, Scott, Rodney J, Setiawan, V Wendy, Shah, Mitul, Sheng, Xin, Shu, Xiao-Ou, Southey, Melissa C, Swerdlow, Anthony J, Tham, Emma, Trovik, Jone, Turman, Constance, Tyrer, Jonathan P, Vachon, Celine, VanDen Berg, David, Vanderstichele, Adriaan, Wang, Zhaoming, Webb, Penelope M, Wentzensen, Nicolas, Werner, Henrica M J, Winham, Stacey J, Wolk, Alicja, Xia, Lucy, Xiang, Yong-Bing, Yang, Hannah P, Yu, Herbert, Zheng, Wei, Pharoah, Paul D P, Dunning, Alison M, Kraft, Peter, De Vivo, Immaculata, Tomlinson, Ian, Easton, Douglas F, Spurdle, Amanda B, and Thompson, Deborah J
- Abstract
Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial cancer cases and 108,979 controls (including new genotype data for 5624 cases) and identify nine novel genome-wide significant loci, including a locus on 12q24.12 previously identified by meta-GWAS of endometrial and colorectal cancer. At five loci, expression quantitative trait locus (eQTL) analyses identify candidate causal genes; risk alleles at two of these loci associate with decreased expression of genes, which encode negative regulators of oncogenic signal transduction proteins (SH2B3 (12q24.12) and NF1 (17q11.2)). In summary, this study has doubled the number of known endometrial cancer risk loci and revealed candidate causal genes for future study.
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- 2018
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71. Analgesic Use and Ovarian Cancer Risk : An Analysis in the Ovarian Cancer Cohort Consortium.
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Trabert, Britton, Poole, Elizabeth M, White, Emily, Visvanathan, Kala, Adami, Hans-Olov, Anderson, Garnet L, Brasky, Theodore M, Brinton, Louise A, Fortner, Renee T, Gaudet, Mia, Hartge, Patricia, Hoffman-Bolton, Judith, Jones, Michael, Lacey, James V, Larsson, Susanna C, Mackenzie, Gerardo G, Schouten, Leo J, Sandler, Dale P, O'Brien, Katie, Patel, Alpa V, Peters, Ulrike, Prizment, Anna, Robien, Kim, Setiawan, V Wendy, Swerdlow, Anthony, van den Brandt, Piet A, Weiderpass, Elisabete, Wilkens, Lynne R, Wolk, Alicja, Wentzensen, Nicolas, Tworoger, Shelley S, Trabert, Britton, Poole, Elizabeth M, White, Emily, Visvanathan, Kala, Adami, Hans-Olov, Anderson, Garnet L, Brasky, Theodore M, Brinton, Louise A, Fortner, Renee T, Gaudet, Mia, Hartge, Patricia, Hoffman-Bolton, Judith, Jones, Michael, Lacey, James V, Larsson, Susanna C, Mackenzie, Gerardo G, Schouten, Leo J, Sandler, Dale P, O'Brien, Katie, Patel, Alpa V, Peters, Ulrike, Prizment, Anna, Robien, Kim, Setiawan, V Wendy, Swerdlow, Anthony, van den Brandt, Piet A, Weiderpass, Elisabete, Wilkens, Lynne R, Wolk, Alicja, Wentzensen, Nicolas, and Tworoger, Shelley S
- Abstract
Background: Aspirin use is associated with reduced risk of several cancers. A pooled analysis of 12 case-control studies showed a 10% decrease in ovarian cancer risk with regular aspirin use, which was stronger for daily and low-dose users. To prospectively investigate associations of analgesic use with ovarian cancer, we analyzed data from 13 studies in the Ovarian Cancer Cohort Consortium (OC3). Methods: The current study included 758 829 women who at study enrollment self-reported analgesic use, among whom 3514 developed ovarian cancer. Using Cox regression, we assessed associations between frequent medication use and risk of ovarian cancer. Dose and duration were also evaluated. All statistical tests were two-sided. Results: Women who used aspirin almost daily (≥6 days/wk) vs infrequent/nonuse experienced a 10% reduction in ovarian cancer risk (rate ratio [RR] = 0.90, 95% confidence interval [CI] = 0.82 to 1.00, P = .05). Frequent use (≥4 days/wk) of aspirin (RR = 0.95, 95% CI = 0.88 to 1.03), nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs; RR = 1.00, 95% CI = 0.90 to 1.11), or acetaminophen (RR = 1.05, 95% CI = 0.88 to 1.24) was not associated with risk. Daily acetaminophen use (RR = 1.28, 95% CI = 1.00 to 1.65, P = .05) was associated with elevated ovarian cancer risk. Risk estimates for frequent, long-term (10+ years) use of aspirin (RR = 1.15, 95% CI = 0.98 to 1.34) or nonaspirin NSAIDs (RR = 1.19, 95% CI = 0.84 to 1.68) were modestly elevated, although not statistically significantly so. Conclusions: This large, prospective analysis suggests that women who use aspirin daily have a slightly lower risk of developing ovarian cancer (∼10% lower than infrequent/nonuse)-similar to the risk reduction observed in case-control analyses. The observed potential elevated risks for 10+ years of frequent aspirin and NSAID use require further study but could be due to confounding by medical indications for use or variation in drug dosing.
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- 2018
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72. Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer
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Phelan, Catherine M. Kuchenbaecker, Karoline B. Tyrer, Jonathan P. Kar, Siddhartha P. Lawrenson, Kate Winham, Stacey J. and Dennis, Joe Pirie, Ailith Riggan, Marjorie J. Chornokur, Ganna Earp, Madalene A. Lyra, Jr., Paulo C. Lee, Janet M. and Coetzee, Simon Beesley, Jonathan McGuffog, Lesley Soucy, Penny Dicks, Ed Lee, Andrew Barrowdale, Daniel and Lecarpentier, Julie Leslie, Goska Aalfs, Cora M. Aben, Katja K. H. Adams, Marcia Adlard, Julian Andrulis, Irene L. and Anton-Culver, Hoda Antonenkova, Natalia Aravantinos, Gerasimos and Arnold, Norbert Arun, Banu K. Arver, Brita Azzollini, Jacopo Balmana, Judith Banerjee, Susana N. Barjhoux, Laure and Barkardottir, Rosa B. Bean, Yukie Beckmann, Matthias W. and Beeghly-Fadiel, Alicia Benitez, Javier Bermisheva, Marina and Bernardini, Marcus Q. Birrer, Michael J. Bjorge, Line Black, Amanda Blankstein, Kenneth Blok, Marinus J. Bodelon, Clara and Bogdanova, Natalia Bojesen, Anders Bonanni, Bernardo and Borg, Ake Bradbury, Angela R. Brenton, James D. Brewer, Carole Brinton, Louise Broberg, Per Brooks-Wilson, Angela and Bruinsma, Fiona Brunet, Joan Buecher, Bruno Butzow, Ralf and Buys, Saundra S. Caldes, Trinidad Caligo, Maria A. and Campbell, Ian Cannioto, Rikki Carney, Michael E. Cescon, Terence Chan, Salina B. Chang-Claude, Jenny Chanock, Stephen and Chen, Xiao Qing Chiew, Yoke-Eng Chiquette, Jocelyne and Chung, Wendy K. Claes, Kathleen B. M. Conner, Thomas Cook, Linda S. Cook, Jackie Cramer, Daniel W. Cunningham, Julie M. and D'Aloisio, Aimee A. Daly, Mary B. Damiola, Francesca and Damirovna, Sakaeva Dina Dansonka-Mieszkowska, Agnieszka Dao, Fanny Davidson, Rosemarie DeFazio, Anna Delnatte, Capucine and Doheny, Kimberly F. Diez, Orland Ding, Yuan Chun and Doherty, Jennifer Anne Domchek, Susan M. Dorfling, Cecilia M. and Dork, Thilo Dossus, Laure Duran, Mercedes Durst, Matthias Dworniczak, Bernd Eccles, Diana Edwards, Todd and Eeles, Ros Eilber, Ursula Ejlertsen, Bent Ekici, Arif B. and Ellis, Steve Elvira, Mingajeva Eng, Kevin H. Engel, Christoph Evans, D. Gareth Fasching, Peter A. Ferguson, Sarah Ferrer, Sandra Fert Flanagan, James M. Fogarty, Zachary C. Fortner, Renee T. Fostira, Florentia Foulkes, William D. Fountzilas, George Fridley, Brooke L. Friebel, Tara M. Friedman, Eitan Frost, Debra Ganz, Patricia A. and Garber, Judy Garcia, Maria J. Garcia-Barberan, Vanesa and Gehrig, Andrea Gentry-Maharaj, Aleksandra Gerdes, Anne-Marie and Giles, Graham G. Glasspool, Rosalind Glendon, Gord Godwin, Andrew K. Goldgar, David E. Goranova, Teodora Gore, Martin and Greene, Mark H. Gronwald, Jacek Gruber, Stephen Hahnen, Eric Haiman, Christopher A. Hakansson, Niclas Hamann, Ute and Hansen, Thomas V. O. Harrington, Patricia A. Harris, Holly R. Hauke, Jan Hein, Alexander Henderson, Alex and Hildebrandt, Michelle A. T. Hillemanns, Peter Hodgson, Shirley and Hogdall, Claus K. Hogdall, Estrid Hogervorst, Frans B. L. and Holland, Helene Hooning, Maartje J. Hosking, Karen and Huang, Ruea-Yea Hulick, Peter J. Hung, Jillian Hunter, David J. Huntsman, David G. Huzarski, Tomasz Imyanitov, Evgeny N. and Isaacs, Claudine Iversen, Edwin S. Izatt, Louise and Izquierdo, Angel Jakubowska, Anna James, Paul Janavicius, Ramunas Jernetz, Mats Jensen, Allan Jensen, Uffe Birk and John, Esther M. Johnatty, Sharon Jones, Michael E. Kannisto, Paivi Karlan, Beth Y. Karnezis, Anthony Kast, Karin and Kennedy, Catherine J. Khusnutdinova, Elza Kiemeney, Lambertus A. and Kiiski, Johanna I. Kim, Sung-Won Kjaer, Susanne K. and Kobel, Martin Kopperud, Reidun K. Kruse, Torben A. and Kupryjanczyk, Jolanta Kwong, Ava Laitman, Yael Lambrechts, Diether Larranaga, Nerea Larson, Melissa C. Lazaro, Conxi and Le, Nhu D. Le Marchand, Loic Lee, Jong Won Lele, Shashikant B. Leminen, Arto Leroux, Dominique Lester, Jenny and Lesueur, Fabienne Levine, Douglas A. Liang, Dong and Liebrich, Clemens Lilyquist, Jenna Lipworth, Loren and Lissowska, Jolanta Lu, Karen H. Lubinski, Jan Luccarini, Craig Lundvall, Lene Mai, Phuong L. Mendoza-Fandino, Gustavo and Manoukian, Siranoush Massuger, Leon F. A. G. May, Taymaa and Mazoyer, Sylvie McAlpine, Jessica N. McGuire, Valerie and McLaughlin, John R. McNeish, Iain Meijers-Heijboer, Hanne and Meindl, Alfons Menon, Usha Mensenkamp, Arjen R. Merritt, Melissa A. Milne, Roger L. Mitchell, Gillian Modugno, Francesmary Moes-Sosnowska, Joanna Moffitt, Melissa and Montagna, Marco Moysich, Kirsten B. Mulligan, Anna Marie and Musinsky, Jacob Nathanson, Katherine L. Nedergaard, Lotte and Ness, Roberta B. Neuhausen, Susan L. Nevanlinna, Heli and Niederacher, Dieter Nussbaum, Robert L. Odunsi, Kunle Olah, Edith Olopade, Olufunmilayo I. Olsson, Hakan Olswold, Curtis and O'Malley, David M. Ong, Kai-ren Onland-Moret, N. Charlotte and Orr, Nicholas Orsulic, Sandra Osorio, Ana Palli, Domenico Papi, Laura Park-Simon, Tjoung-Won Paul, James and Pearce, Celeste L. Pedersen, Inge Sokilde Peeters, Petra H. M. and Peissel, Bernard Peixoto, Ana Pejovic, Tanja Pelttari, Liisa M. Permuth, Jennifer B. Peterlongo, Paolo Pezzani, Lidia Pfeiler, Georg Phillips, Kelly-Anne Piedmonte, Marion and Pike, Malcolm C. Piskorz, Anna M. Poblete, Samantha R. and Pocza, Timea Poole, Elizabeth M. Poppe, Bruce Porteous, Mary E. Prieur, Fabienne Prokofyeva, Darya Pugh, Elizabeth and Pujana, Miquel Angel Pujol, Pascal Radice, Paolo Rantala, Johanna Rappaport-Fuerhauser, Christine Rennert, Gad Rhiem, Kerstin Rice, Patricia Richardson, Andrea Robson, Mark and Rodriguez, Gustavo C. Rodriguez-Antona, Cristina Romm, Jane and Rookus, Matti A. Rossing, Mary Anne Rothstein, Joseph H. and Rudolph, Anja Runnebaum, Ingo B. Salvesen, Helga B. Sandler, Dale P. Schoemaker, Minouk J. Senter, Leigha Setiawan, V. Wendy Severi, Gianluca Sharma, Priyanka Shelford, Tameka and Siddiqui, Nadeem Side, Lucy E. Sieh, Weiva Singer, Christian F. Sobol, Hagay Song, Honglin Southey, Melissa C. and Spurdle, Amanda B. Stadler, Zsofia Steinemann, Doris and Stoppa-Lyonnet, Dominique Sucheston-Campbell, Lara E. and Sukiennicki, Grzegorz Sutphen, Rebecca Sutter, Christian and Swerdlow, Anthony J. Szabo, Csilla I. Szafron, Lukasz Tan, Yen Y. Taylor, Jack A. Tea, Muy-Kheng Teixeira, Manuel R. and Teo, Soo-Hwang Terry, Kathryn L. Thompson, Pamela J. and Thomsen, Liv Cecilie Vestrheim Thull, Darcy L. Tihomirova, Laima and Tinker, Anna V. Tischkowitz, Marc Tognazzo, Silvia and Toland, Amanda Ewart Tone, Alicia Trabert, Britton Travis, Ruth C. Trichopoulou, Antonia Tung, Nadine Tworoger, Shelley S. Van Altena, Anne M. Van den Berg, David van der Hout, Annemarie H. van der Luijt, Rob B. Van Heetvelde, Mattias and Van Nieuwenhuysen, Els Van Rensburg, Elizabeth J. and Vanderstichele, Adriaan Varon-Mateeva, Raymonda Vega, Ana and Edwards, Digna Velez Vergote, Ignace Vierkant, Robert A. and Vijai, Joseph Vratimos, Athanassios Walker, Lisa Walsh, Christine Wand, Dorothea Wang-Gohrke, Shan Wappenschmidt, Barbara Webb, Penelope M. Weinberg, Clarice R. Weitzel, Jeffrey N. Wentzensen, Nicolas Whittemore, Alice S. Wijnen, Juul T. Wilkens, Lynne R. Wolk, Alicja Woo, Michelle Wu, Xifeng Wu, Anna H. Yang, Hannah Yannoukakos, Drakoulis and Ziogas, Argyrios Zorn, Kristin K. Narod, Steven A. Easton, Douglas F. Amos, Christopher I. Schildkraut, Joellen M. and Ramus, Susan J. Ottini, Laura Goodman, Marc T. Park-, Sue K. and Kelemen, Linda E. Risch, Harvey A. Thomassen, Mads and Offit, Kenneth Simard, Jacques Schmutzler, Rita Katharina and Hazelett, Dennis Monteiro, Alvaro N. Couch, Fergus J. and Berchuck, Andrew Chenevix-Trench, Georgia Goode, Ellen L. and Sellers, Thomas A. Gayther, Simon A. Antoniou, Antonis C. and Pharoah, Paul D. P. AOCS Study Grp EMEMBRACE Study GEMO Study Collaborators HEBON Study KConFab Investigators OPAL Study Grp
- Subjects
endocrine system diseases ,female genital diseases and pregnancy complications - Abstract
To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.
- Published
- 2017
73. Identification of nine new susceptibility loci for endometrial cancer
- Author
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O’Mara, Tracy A., primary, Glubb, Dylan M., additional, Amant, Frederic, additional, Annibali, Daniela, additional, Ashton, Katie, additional, Attia, John, additional, Auer, Paul L., additional, Beckmann, Matthias W., additional, Black, Amanda, additional, Bolla, Manjeet K., additional, Brauch, Hiltrud, additional, Brenner, Hermann, additional, Brinton, Louise, additional, Buchanan, Daniel D., additional, Burwinkel, Barbara, additional, Chang-Claude, Jenny, additional, Chanock, Stephen J., additional, Chen, Chu, additional, Chen, Maxine M., additional, Cheng, Timothy H. T., additional, Clarke, Christine L., additional, Clendenning, Mark, additional, Cook, Linda S., additional, Couch, Fergus J., additional, Cox, Angela, additional, Crous-Bous, Marta, additional, Czene, Kamila, additional, Day, Felix, additional, Dennis, Joe, additional, Depreeuw, Jeroen, additional, Doherty, Jennifer Anne, additional, Dörk, Thilo, additional, Dowdy, Sean C., additional, Dürst, Matthias, additional, Ekici, Arif B., additional, Fasching, Peter A., additional, Fridley, Brooke L., additional, Friedenreich, Christine M., additional, Fritschi, Lin, additional, Fung, Jenny, additional, García-Closas, Montserrat, additional, Gaudet, Mia M., additional, Giles, Graham G., additional, Goode, Ellen L., additional, Gorman, Maggie, additional, Haiman, Christopher A., additional, Hall, Per, additional, Hankison, Susan E., additional, Healey, Catherine S., additional, Hein, Alexander, additional, Hillemanns, Peter, additional, Hodgson, Shirley, additional, Hoivik, Erling A., additional, Holliday, Elizabeth G., additional, Hopper, John L., additional, Hunter, David J., additional, Jones, Angela, additional, Krakstad, Camilla, additional, Kristensen, Vessela N., additional, Lambrechts, Diether, additional, Marchand, Loic Le, additional, Liang, Xiaolin, additional, Lindblom, Annika, additional, Lissowska, Jolanta, additional, Long, Jirong, additional, Lu, Lingeng, additional, Magliocco, Anthony M., additional, Martin, Lynn, additional, McEvoy, Mark, additional, Meindl, Alfons, additional, Michailidou, Kyriaki, additional, Milne, Roger L., additional, Mints, Miriam, additional, Montgomery, Grant W., additional, Nassir, Rami, additional, Olsson, Håkan, additional, Orlow, Irene, additional, Otton, Geoffrey, additional, Palles, Claire, additional, Perry, John R. B., additional, Peto, Julian, additional, Pooler, Loreall, additional, Prescott, Jennifer, additional, Proietto, Tony, additional, Rebbeck, Timothy R., additional, Risch, Harvey A., additional, Rogers, Peter A. W., additional, Rübner, Matthias, additional, Runnebaum, Ingo, additional, Sacerdote, Carlotta, additional, Sarto, Gloria E., additional, Schumacher, Fredrick, additional, Scott, Rodney J., additional, Setiawan, V. Wendy, additional, Shah, Mitul, additional, Sheng, Xin, additional, Shu, Xiao-Ou, additional, Southey, Melissa C., additional, Swerdlow, Anthony J., additional, Tham, Emma, additional, Trovik, Jone, additional, Turman, Constance, additional, Tyrer, Jonathan P., additional, Vachon, Celine, additional, VanDen Berg, David, additional, Vanderstichele, Adriaan, additional, Wang, Zhaoming, additional, Webb, Penelope M., additional, Wentzensen, Nicolas, additional, Werner, Henrica M. J., additional, Winham, Stacey J., additional, Wolk, Alicja, additional, Xia, Lucy, additional, Xiang, Yong-Bing, additional, Yang, Hannah P., additional, Yu, Herbert, additional, Zheng, Wei, additional, Pharoah, Paul D. P., additional, Dunning, Alison M., additional, Kraft, Peter, additional, De Vivo, Immaculata, additional, Tomlinson, Ian, additional, Easton, Douglas F., additional, Spurdle, Amanda B., additional, and Thompson, Deborah J., additional
- Published
- 2018
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74. Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer
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Phelan, Catherine M., Kuchenbaecker, Karoline B., Tyrer, Jonathan P., Kar, Siddhartha P., Lawrenson, Kate, Winham, Stacey J., Dennis, Joe, Pirie, Ailith, Riggan, Marjorie J., Chornokur, Ganna, Earp, Madalene A., Lyra, Paulo C., Jr., Lee, Janet M., Coetzee, Simon, Beesley, Jonathan, McGuffog, Lesley, Soucy, Penny, Dicks, Ed, Lee, Andrew, Barrowdale, Daniel, Lecarpentier, Julie, Leslie, Goska, Aalfs, Cora M., Aben, Katja K. H., Adams, Marcia, Adlard, Julian, Andrulis, Irene L., Anton-Culver, Hoda, Antonenkova, Natalia, Aravantinos, Gerasimos, Arnold, Norbert, Arun, Banu K., Arver, Brita, Azzollini, Jacopo, Balmana, Judith, Banerjee, Susana N., Barjhoux, Laure, Barkardottir, Rosa B., Bean, Yukie, Beckmann, Matthias W., Beeghly-Fadiel, Alicia, Benitez, Javier, Bermisheva, Marina, Bernardini, Marcus Q., Birrer, Michael J., Bjorge, Line, Black, Amanda, Blankstein, Kenneth, Blok, Marinus J., Bodelon, Clara, Bogdanova, Natalia, Bojesen, Anders, Bonanni, Bernardo, Borg, Ake, Bradbury, Angela R., Brenton, James D., Brewer, Carole, Brinton, Louise, Broberg, Per, Brooks-Wilson, Angela, Bruinsma, Fiona, Brunet, Joan, Buecher, Bruno, Butzow, Ralf, Buys, Saundra S., Caldes, Trinidad, Caligo, Maria A., Campbell, Ian, Cannioto, Rikki, Carney, Michael E., Cescon, Terence, Chan, Salina B., Chang-Claude, Jenny, Chanock, Stephen, Chen, Xiao Qing, Chiew, Yoke-Eng, Chiquette, Jocelyne, Chung, Wendy K., Claes, Kathleen B. M., Conner, Thomas, Cook, Linda S., Cook, Jackie, Cramer, Daniel W., Cunningham, Julie M., D'Aloisio, Aimee A., Daly, Mary B., Damiola, Francesca, Damirovna, Sakaeva Dina, Dansonka-Mieszkowska, Agnieszka, Dao, Fanny, Davidson, Rosemarie, DeFazio, Anna, Delnatte, Capucine, Doheny, Kimberly F., Diez, Orland, Ding, Yuan Chun, Doherty, Jennifer Anne, Domchek, Susan M., Dorfling, Cecilia M., Dork, Thilo, Dossus, Laure, Duran, Mercedes, Durst, Matthias, Dworniczak, Bernd, Eccles, Diana, Edwards, Todd, Eeles, Ros, Eilber, Ursula, Ejlertsen, Bent, Ekici, Arif B., Ellis, Steve, Elvira, Mingajeva, Eng, Kevin H., Engel, Christoph, Evans, D. Gareth, Fasching, Peter A., Ferguson, Sarah, Ferrer, Sandra Fert, Flanagan, James M., Fogarty, Zachary C., Fortner, Renee T., Fostira, Florentia, Foulkes, William D., Fountzilas, George, Fridley, Brooke L., Friebel, Tara M., Friedman, Eitan, Frost, Debra, Ganz, Patricia A., Garber, Judy, Garcia, Maria J., Garcia-Barberan, Vanesa, Gehrig, Andrea, Gentry-Maharaj, Aleksandra, Gerdes, Anne-Marie, Giles, Graham G., Glasspool, Rosalind, Glendon, Gord, Godwin, Andrew K., Goldgar, David E., Goranova, Teodora, Gore, Martin, Greene, Mark H., Gronwald, Jacek, Gruber, Stephen, Hahnen, Eric, Haiman, Christopher A., Hakansson, Niclas, Hamann, Ute, Hansen, Thomas V. O., Harrington, Patricia A., Harris, Holly R., Hauke, Jan, Hein, Alexander, Henderson, Alex, Hildebrandt, Michelle A. T., Hillemanns, Peter, Hodgson, Shirley, Hogdall, Claus K., Hogdall, Estrid, Hogervorst, Frans B. L., Holland, Helene, Hooning, Maartje J., Hosking, Karen, Huang, Ruea-Yea, Hulick, Peter J., Hung, Jillian, Hunter, David J., Huntsman, David G., Huzarski, Tomasz, Imyanitov, Evgeny N., Isaacs, Claudine, Iversen, Edwin S., Izatt, Louise, Izquierdo, Angel, Jakubowska, Anna, James, Paul, Janavicius, Ramunas, Jernetz, Mats, Jensen, Allan, Jensen, Uffe Birk, John, Esther M., Johnatty, Sharon, Jones, Michael E., Kannisto, Paivi, Karlan, Beth Y., Karnezis, Anthony, Kast, Karin, Kennedy, Catherine J., Khusnutdinova, Elza, Kiemeney, Lambertus A., Kiiski, Johanna I., Kim, Sung-Won, Kjaer, Susanne K., Kobel, Martin, Kopperud, Reidun K., Kruse, Torben A., Kupryjanczyk, Jolanta, Kwong, Ava, Laitman, Yael, Lambrechts, Diether, Larranaga, Nerea, Larson, Melissa C., Lazaro, Conxi, Le, Nhu D., Le Marchand, Loic, Lee, Jong Won, Lele, Shashikant B., Leminen, Arto, Leroux, Dominique, Lester, Jenny, Lesueur, Fabienne, Levine, Douglas A., Liang, Dong, Liebrich, Clemens, Lilyquist, Jenna, Lipworth, Loren, Lissowska, Jolanta, Lu, Karen H., Lubinski, Jan, Luccarini, Craig, Lundvall, Lene, Mai, Phuong L., Mendoza-Fandino, Gustavo, Manoukian, Siranoush, Massuger, Leon F. A. G., May, Taymaa, Mazoyer, Sylvie, McAlpine, Jessica N., McGuire, Valerie, McLaughlin, John R., McNeish, Iain, Meijers-Heijboer, Hanne, Meindl, Alfons, Menon, Usha, Mensenkamp, Arjen R., Merritt, Melissa A., Milne, Roger L., Mitchell, Gillian, Modugno, Francesmary, Moes-Sosnowska, Joanna, Moffitt, Melissa, Montagna, Marco, Moysich, Kirsten B., Mulligan, Anna Marie, Musinsky, Jacob, Nathanson, Katherine L., Nedergaard, Lotte, Ness, Roberta B., Neuhausen, Susan L., Nevanlinna, Heli, Niederacher, Dieter, Nussbaum, Robert L., Odunsi, Kunle, Olah, Edith, Olopade, Olufunmilayo I., Olsson, Hakan, Olswold, Curtis, O'Malley, David M., Ong, Kai-ren, Onland-Moret, N. Charlotte, Orr, Nicholas, Orsulic, Sandra, Osorio, Ana, Palli, Domenico, Papi, Laura, Park-Simon, Tjoung-Won, Paul, James, Pearce, Celeste L., Pedersen, Inge Sokilde, Peeters, Petra H. M., Peissel, Bernard, Peixoto, Ana, Pejovic, Tanja, Pelttari, Liisa M., Permuth, Jennifer B., Peterlongo, Paolo, Pezzani, Lidia, Pfeiler, Georg, Phillips, Kelly-Anne, Piedmonte, Marion, Pike, Malcolm C., Piskorz, Anna M., Poblete, Samantha R., Pocza, Timea, Poole, Elizabeth M., Poppe, Bruce, Porteous, Mary E., Prieur, Fabienne, Prokofyeva, Darya, Pugh, Elizabeth, Pujana, Miquel Angel, Pujol, Pascal, Radice, Paolo, Rantala, Johanna, Rappaport-Fuerhauser, Christine, Rennert, Gad, Rhiem, Kerstin, Rice, Patricia, Richardson, Andrea, Robson, Mark, Rodriguez, Gustavo C., Rodriguez-Antona, Cristina, Romm, Jane, Rookus, Matti A., Rossing, Mary Anne, Rothstein, Joseph H., Rudolph, Anja, Runnebaum, Ingo B., Salvesen, Helga B., Sandler, Dale P., Schoemaker, Minouk J., Senter, Leigha, Setiawan, V. Wendy, Severi, Gianluca, Sharma, Priyanka, Shelford, Tameka, Siddiqui, Nadeem, Side, Lucy E., Sieh, Weiva, Singer, Christian F., Sobol, Hagay, Song, Honglin, Southey, Melissa C., Spurdle, Amanda B., Stadler, Zsofia, Steinemann, Doris, Stoppa-Lyonnet, Dominique, Sucheston-Campbell, Lara E., Sukiennicki, Grzegorz, Sutphen, Rebecca, Sutter, Christian, Swerdlow, Anthony J., Szabo, Csilla I., Szafron, Lukasz, Tan, Yen Y., Taylor, Jack A., Tea, Muy-Kheng, Teixeira, Manuel R., Teo, Soo-Hwang, Terry, Kathryn L., Thompson, Pamela J., Thomsen, Liv Cecilie Vestrheim, Thull, Darcy L., Tihomirova, Laima, Tinker, Anna V., Tischkowitz, Marc, Tognazzo, Silvia, Toland, Amanda Ewart, Tone, Alicia, Trabert, Britton, Travis, Ruth C., Trichopoulou, Antonia, Tung, Nadine, Tworoger, Shelley S., Van Altena, Anne M., Van den Berg, David, van der Hout, Annemarie H., van der Luijt, Rob B., Van Heetvelde, Mattias, Van Nieuwenhuysen, Els, Van Rensburg, Elizabeth J., Vanderstichele, Adriaan, Varon-Mateeva, Raymonda, Vega, Ana, Edwards, Digna Velez, Vergote, Ignace, Vierkant, Robert A., Vijai, Joseph, Vratimos, Athanassios, Walker, Lisa, Walsh, Christine, Wand, Dorothea, Wang-Gohrke, Shan, Wappenschmidt, Barbara, Webb, Penelope M., Weinberg, Clarice R., Weitzel, Jeffrey N., Wentzensen, Nicolas, Whittemore, Alice S., Wijnen, Juul T., Wilkens, Lynne R., Wolk, Alicja, Woo, Michelle, Wu, Xifeng, Wu, Anna H., Yang, Hannah, Yannoukakos, Drakoulis, Ziogas, Argyrios, Zorn, Kristin K., Narod, Steven A., Easton, Douglas F., Amos, Christopher I., Schildkraut, Joellen M., Ramus, Susan J., Ottini, Laura, Goodman, Marc T., Park-, Sue K., Kelemen, Linda E., Risch, Harvey A., Thomassen, Mads, Offit, Kenneth, Simard, Jacques, Schmutzler, Rita Katharina, Hazelett, Dennis, Monteiro, Alvaro N., Couch, Fergus J., Berchuck, Andrew, Chenevix-Trench, Georgia, Goode, Ellen L., Sellers, Thomas A., Gayther, Simon A., Antoniou, Antonis C., Pharoah, Paul D. P., Phelan, Catherine M., Kuchenbaecker, Karoline B., Tyrer, Jonathan P., Kar, Siddhartha P., Lawrenson, Kate, Winham, Stacey J., Dennis, Joe, Pirie, Ailith, Riggan, Marjorie J., Chornokur, Ganna, Earp, Madalene A., Lyra, Paulo C., Jr., Lee, Janet M., Coetzee, Simon, Beesley, Jonathan, McGuffog, Lesley, Soucy, Penny, Dicks, Ed, Lee, Andrew, Barrowdale, Daniel, Lecarpentier, Julie, Leslie, Goska, Aalfs, Cora M., Aben, Katja K. H., Adams, Marcia, Adlard, Julian, Andrulis, Irene L., Anton-Culver, Hoda, Antonenkova, Natalia, Aravantinos, Gerasimos, Arnold, Norbert, Arun, Banu K., Arver, Brita, Azzollini, Jacopo, Balmana, Judith, Banerjee, Susana N., Barjhoux, Laure, Barkardottir, Rosa B., Bean, Yukie, Beckmann, Matthias W., Beeghly-Fadiel, Alicia, Benitez, Javier, Bermisheva, Marina, Bernardini, Marcus Q., Birrer, Michael J., Bjorge, Line, Black, Amanda, Blankstein, Kenneth, Blok, Marinus J., Bodelon, Clara, Bogdanova, Natalia, Bojesen, Anders, Bonanni, Bernardo, Borg, Ake, Bradbury, Angela R., Brenton, James D., Brewer, Carole, Brinton, Louise, Broberg, Per, Brooks-Wilson, Angela, Bruinsma, Fiona, Brunet, Joan, Buecher, Bruno, Butzow, Ralf, Buys, Saundra S., Caldes, Trinidad, Caligo, Maria A., Campbell, Ian, Cannioto, Rikki, Carney, Michael E., Cescon, Terence, Chan, Salina B., Chang-Claude, Jenny, Chanock, Stephen, Chen, Xiao Qing, Chiew, Yoke-Eng, Chiquette, Jocelyne, Chung, Wendy K., Claes, Kathleen B. M., Conner, Thomas, Cook, Linda S., Cook, Jackie, Cramer, Daniel W., Cunningham, Julie M., D'Aloisio, Aimee A., Daly, Mary B., Damiola, Francesca, Damirovna, Sakaeva Dina, Dansonka-Mieszkowska, Agnieszka, Dao, Fanny, Davidson, Rosemarie, DeFazio, Anna, Delnatte, Capucine, Doheny, Kimberly F., Diez, Orland, Ding, Yuan Chun, Doherty, Jennifer Anne, Domchek, Susan M., Dorfling, Cecilia M., Dork, Thilo, Dossus, Laure, Duran, Mercedes, Durst, Matthias, Dworniczak, Bernd, Eccles, Diana, Edwards, Todd, Eeles, Ros, Eilber, Ursula, Ejlertsen, Bent, Ekici, Arif B., Ellis, Steve, Elvira, Mingajeva, Eng, Kevin H., Engel, Christoph, Evans, D. Gareth, Fasching, Peter A., Ferguson, Sarah, Ferrer, Sandra Fert, Flanagan, James M., Fogarty, Zachary C., Fortner, Renee T., Fostira, Florentia, Foulkes, William D., Fountzilas, George, Fridley, Brooke L., Friebel, Tara M., Friedman, Eitan, Frost, Debra, Ganz, Patricia A., Garber, Judy, Garcia, Maria J., Garcia-Barberan, Vanesa, Gehrig, Andrea, Gentry-Maharaj, Aleksandra, Gerdes, Anne-Marie, Giles, Graham G., Glasspool, Rosalind, Glendon, Gord, Godwin, Andrew K., Goldgar, David E., Goranova, Teodora, Gore, Martin, Greene, Mark H., Gronwald, Jacek, Gruber, Stephen, Hahnen, Eric, Haiman, Christopher A., Hakansson, Niclas, Hamann, Ute, Hansen, Thomas V. O., Harrington, Patricia A., Harris, Holly R., Hauke, Jan, Hein, Alexander, Henderson, Alex, Hildebrandt, Michelle A. T., Hillemanns, Peter, Hodgson, Shirley, Hogdall, Claus K., Hogdall, Estrid, Hogervorst, Frans B. L., Holland, Helene, Hooning, Maartje J., Hosking, Karen, Huang, Ruea-Yea, Hulick, Peter J., Hung, Jillian, Hunter, David J., Huntsman, David G., Huzarski, Tomasz, Imyanitov, Evgeny N., Isaacs, Claudine, Iversen, Edwin S., Izatt, Louise, Izquierdo, Angel, Jakubowska, Anna, James, Paul, Janavicius, Ramunas, Jernetz, Mats, Jensen, Allan, Jensen, Uffe Birk, John, Esther M., Johnatty, Sharon, Jones, Michael E., Kannisto, Paivi, Karlan, Beth Y., Karnezis, Anthony, Kast, Karin, Kennedy, Catherine J., Khusnutdinova, Elza, Kiemeney, Lambertus A., Kiiski, Johanna I., Kim, Sung-Won, Kjaer, Susanne K., Kobel, Martin, Kopperud, Reidun K., Kruse, Torben A., Kupryjanczyk, Jolanta, Kwong, Ava, Laitman, Yael, Lambrechts, Diether, Larranaga, Nerea, Larson, Melissa C., Lazaro, Conxi, Le, Nhu D., Le Marchand, Loic, Lee, Jong Won, Lele, Shashikant B., Leminen, Arto, Leroux, Dominique, Lester, Jenny, Lesueur, Fabienne, Levine, Douglas A., Liang, Dong, Liebrich, Clemens, Lilyquist, Jenna, Lipworth, Loren, Lissowska, Jolanta, Lu, Karen H., Lubinski, Jan, Luccarini, Craig, Lundvall, Lene, Mai, Phuong L., Mendoza-Fandino, Gustavo, Manoukian, Siranoush, Massuger, Leon F. A. G., May, Taymaa, Mazoyer, Sylvie, McAlpine, Jessica N., McGuire, Valerie, McLaughlin, John R., McNeish, Iain, Meijers-Heijboer, Hanne, Meindl, Alfons, Menon, Usha, Mensenkamp, Arjen R., Merritt, Melissa A., Milne, Roger L., Mitchell, Gillian, Modugno, Francesmary, Moes-Sosnowska, Joanna, Moffitt, Melissa, Montagna, Marco, Moysich, Kirsten B., Mulligan, Anna Marie, Musinsky, Jacob, Nathanson, Katherine L., Nedergaard, Lotte, Ness, Roberta B., Neuhausen, Susan L., Nevanlinna, Heli, Niederacher, Dieter, Nussbaum, Robert L., Odunsi, Kunle, Olah, Edith, Olopade, Olufunmilayo I., Olsson, Hakan, Olswold, Curtis, O'Malley, David M., Ong, Kai-ren, Onland-Moret, N. Charlotte, Orr, Nicholas, Orsulic, Sandra, Osorio, Ana, Palli, Domenico, Papi, Laura, Park-Simon, Tjoung-Won, Paul, James, Pearce, Celeste L., Pedersen, Inge Sokilde, Peeters, Petra H. M., Peissel, Bernard, Peixoto, Ana, Pejovic, Tanja, Pelttari, Liisa M., Permuth, Jennifer B., Peterlongo, Paolo, Pezzani, Lidia, Pfeiler, Georg, Phillips, Kelly-Anne, Piedmonte, Marion, Pike, Malcolm C., Piskorz, Anna M., Poblete, Samantha R., Pocza, Timea, Poole, Elizabeth M., Poppe, Bruce, Porteous, Mary E., Prieur, Fabienne, Prokofyeva, Darya, Pugh, Elizabeth, Pujana, Miquel Angel, Pujol, Pascal, Radice, Paolo, Rantala, Johanna, Rappaport-Fuerhauser, Christine, Rennert, Gad, Rhiem, Kerstin, Rice, Patricia, Richardson, Andrea, Robson, Mark, Rodriguez, Gustavo C., Rodriguez-Antona, Cristina, Romm, Jane, Rookus, Matti A., Rossing, Mary Anne, Rothstein, Joseph H., Rudolph, Anja, Runnebaum, Ingo B., Salvesen, Helga B., Sandler, Dale P., Schoemaker, Minouk J., Senter, Leigha, Setiawan, V. Wendy, Severi, Gianluca, Sharma, Priyanka, Shelford, Tameka, Siddiqui, Nadeem, Side, Lucy E., Sieh, Weiva, Singer, Christian F., Sobol, Hagay, Song, Honglin, Southey, Melissa C., Spurdle, Amanda B., Stadler, Zsofia, Steinemann, Doris, Stoppa-Lyonnet, Dominique, Sucheston-Campbell, Lara E., Sukiennicki, Grzegorz, Sutphen, Rebecca, Sutter, Christian, Swerdlow, Anthony J., Szabo, Csilla I., Szafron, Lukasz, Tan, Yen Y., Taylor, Jack A., Tea, Muy-Kheng, Teixeira, Manuel R., Teo, Soo-Hwang, Terry, Kathryn L., Thompson, Pamela J., Thomsen, Liv Cecilie Vestrheim, Thull, Darcy L., Tihomirova, Laima, Tinker, Anna V., Tischkowitz, Marc, Tognazzo, Silvia, Toland, Amanda Ewart, Tone, Alicia, Trabert, Britton, Travis, Ruth C., Trichopoulou, Antonia, Tung, Nadine, Tworoger, Shelley S., Van Altena, Anne M., Van den Berg, David, van der Hout, Annemarie H., van der Luijt, Rob B., Van Heetvelde, Mattias, Van Nieuwenhuysen, Els, Van Rensburg, Elizabeth J., Vanderstichele, Adriaan, Varon-Mateeva, Raymonda, Vega, Ana, Edwards, Digna Velez, Vergote, Ignace, Vierkant, Robert A., Vijai, Joseph, Vratimos, Athanassios, Walker, Lisa, Walsh, Christine, Wand, Dorothea, Wang-Gohrke, Shan, Wappenschmidt, Barbara, Webb, Penelope M., Weinberg, Clarice R., Weitzel, Jeffrey N., Wentzensen, Nicolas, Whittemore, Alice S., Wijnen, Juul T., Wilkens, Lynne R., Wolk, Alicja, Woo, Michelle, Wu, Xifeng, Wu, Anna H., Yang, Hannah, Yannoukakos, Drakoulis, Ziogas, Argyrios, Zorn, Kristin K., Narod, Steven A., Easton, Douglas F., Amos, Christopher I., Schildkraut, Joellen M., Ramus, Susan J., Ottini, Laura, Goodman, Marc T., Park-, Sue K., Kelemen, Linda E., Risch, Harvey A., Thomassen, Mads, Offit, Kenneth, Simard, Jacques, Schmutzler, Rita Katharina, Hazelett, Dennis, Monteiro, Alvaro N., Couch, Fergus J., Berchuck, Andrew, Chenevix-Trench, Georgia, Goode, Ellen L., Sellers, Thomas A., Gayther, Simon A., Antoniou, Antonis C., and Pharoah, Paul D. P.
- Abstract
To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.
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- 2017
75. Ovarian Cancer Risk Factors by Histologic Subtype : An Analysis From the Ovarian Cancer Cohort Consortium
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Wentzensen, Nicolas, Poole, Elizabeth M., Trabert, Britton, White, Emily, Arslan, Alan A., Patel, Alpa V., Setiawan, V. Wendy, Visvanathan, Kala, Weiderpass, Elisabete, Adami, Hans-Olov, Black, Amanda, Bernstein, Leslie, Brinton, Louise A., Buring, Julie, Butler, Lesley M., Chamosa, Saioa, Clendenen, Tess V., Dossus, Laure, Fortner, Renee, Gapstur, Susan M., Gaudet, Mia M., Gram, Inger T., Hartge, Patricia, Hoffman-Bolton, Judith, Idahl, Annika, Jones, Michael, Kaaks, Rudolf, Kirsh, Victoria, Koh, Woon-Puay, Lacey, James V., Jr., Lee, I-Min, Lundin, Eva, Merritt, Melissa A., Onland-Moret, N. Charlotte, Peters, Ulrike, Poynter, Jenny N., Rinaldi, Sabina, Robien, Kim, Rohan, Thomas, Sandler, Dale P., Schairer, Catherine, Schouten, Leo J., Sjoholm, Louise K., Sieri, Sabina, Swerdlow, Anthony, Tjonneland, Anna, Travis, Ruth, Trichopoulou, Antonia, van den Brandt, Piet A., Wilkens, Lynne, Wolk, Alicja, Yang, Hannah P., Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S., Wentzensen, Nicolas, Poole, Elizabeth M., Trabert, Britton, White, Emily, Arslan, Alan A., Patel, Alpa V., Setiawan, V. Wendy, Visvanathan, Kala, Weiderpass, Elisabete, Adami, Hans-Olov, Black, Amanda, Bernstein, Leslie, Brinton, Louise A., Buring, Julie, Butler, Lesley M., Chamosa, Saioa, Clendenen, Tess V., Dossus, Laure, Fortner, Renee, Gapstur, Susan M., Gaudet, Mia M., Gram, Inger T., Hartge, Patricia, Hoffman-Bolton, Judith, Idahl, Annika, Jones, Michael, Kaaks, Rudolf, Kirsh, Victoria, Koh, Woon-Puay, Lacey, James V., Jr., Lee, I-Min, Lundin, Eva, Merritt, Melissa A., Onland-Moret, N. Charlotte, Peters, Ulrike, Poynter, Jenny N., Rinaldi, Sabina, Robien, Kim, Rohan, Thomas, Sandler, Dale P., Schairer, Catherine, Schouten, Leo J., Sjoholm, Louise K., Sieri, Sabina, Swerdlow, Anthony, Tjonneland, Anna, Travis, Ruth, Trichopoulou, Antonia, van den Brandt, Piet A., Wilkens, Lynne, Wolk, Alicja, Yang, Hannah P., Zeleniuch-Jacquotte, Anne, and Tworoger, Shelley S.
- Abstract
Purpose An understanding of the etiologic heterogeneity of ovarian cancer is important for improving prevention, early detection, and therapeutic approaches. We evaluated 14 hormonal, reproductive, and lifestyle factors by histologic subtype in the Ovarian Cancer Cohort Consortium (OC3). Patients and Methods Among 1.3 million women from 21 studies, 5,584 invasive epithelial ovarian cancers were identified (3,378 serous, 606 endometrioid, 331 mucinous, 269 clear cell, 1,000 other). By using competing risks Cox proportional hazards regression stratified by study and birth year and adjusted for age, parity, and oral contraceptive use, we assessed associations for all invasive cancers by histology. Heterogeneity was evaluated by likelihood ratio test. Results Most risk factors exhibited significant heterogeneity by histology. Higher parity was most strongly associated with endometrioid (relative risk [RR] per birth, 0.78; 95% CI, 0.74 to 0.83) and clear cell (RR, 0.68; 95% CI, 0.61 to 0.76) carcinomas (P value for heterogeneity [P-het] < .001). Similarly, age at menopause, endometriosis, and tubal ligation were only associated with endometrioid and clear cell tumors (P-het <= .01). Family history of breast cancer (P-het = .008) had modest heterogeneity. Smoking was associated with an increased risk of mucinous (RR per 20 pack-years, 1.26; 95% CI, 1.08 to 1.46) but a decreased risk of clear cell (RR, 0.72; 95% CI, 0.55 to 0.94) tumors (P-het = .004). Unsupervised clustering by risk factors separated endometrioid, clear cell, and low-grade serous carcinomas from high-grade serous and mucinous carcinomas. Conclusion The heterogeneous associations of risk factors with ovarian cancer subtypes emphasize the importance of conducting etiologic studies by ovarian cancer subtypes. Most established risk factors were more strongly associated with nonserous carcinomas, which demonstrate challenges for risk prediction of serous cancers, the most fatal subtype. (C) 2016 by Ameri
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- 2016
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76. Ovarian Cancer Risk Factors by Histologic Subtype: An Analysis From the Ovarian Cancer Cohort Consortium
- Author
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Cardiovasculaire Epi Team 3, Circulatory Health, Cancer, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Kanker, Brain, Wentzensen, Nicolas, Poole, Elizabeth M, Trabert, Britton, White, Emily, Arslan, Alan A, Patel, Alpa V, Setiawan, V Wendy, Visvanathan, Kala, Weiderpass, Elisabete, Adami, Hans-Olov, Black, Amanda, Bernstein, Leslie, Brinton, Louise A, Buring, Julie, Butler, Lesley M, Chamosa, Saioa, Clendenen, Tess V, Dossus, Laure, Fortner, Renee, Gapstur, Susan M, Gaudet, Mia M, Gram, Inger T, Hartge, Patricia, Hoffman-Bolton, Judith, Idahl, Annika, Jones, Michael, Kaaks, Rudolf, Kirsh, Victoria, Koh, Woon-Puay, Lacey, James V, Lee, I-Min, Lundin, Eva, Merritt, Melissa A, Onland-Moret, N Charlotte, Peters, Ulrike, Poynter, Jenny N, Rinaldi, Sabina, Robien, Kim, Rohan, Thomas, Sandler, Dale P, Schairer, Catherine, Schouten, Leo J, Sjöholm, Louise K, Sieri, Sabina, Swerdlow, Anthony, Tjonneland, Anna, Travis, Ruth, Trichopoulou, Antonia, van den Brandt, Piet A, Wilkens, Lynne, Wolk, Alicja, Yang, Hannah P, Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S, Cardiovasculaire Epi Team 3, Circulatory Health, Cancer, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Kanker, Brain, Wentzensen, Nicolas, Poole, Elizabeth M, Trabert, Britton, White, Emily, Arslan, Alan A, Patel, Alpa V, Setiawan, V Wendy, Visvanathan, Kala, Weiderpass, Elisabete, Adami, Hans-Olov, Black, Amanda, Bernstein, Leslie, Brinton, Louise A, Buring, Julie, Butler, Lesley M, Chamosa, Saioa, Clendenen, Tess V, Dossus, Laure, Fortner, Renee, Gapstur, Susan M, Gaudet, Mia M, Gram, Inger T, Hartge, Patricia, Hoffman-Bolton, Judith, Idahl, Annika, Jones, Michael, Kaaks, Rudolf, Kirsh, Victoria, Koh, Woon-Puay, Lacey, James V, Lee, I-Min, Lundin, Eva, Merritt, Melissa A, Onland-Moret, N Charlotte, Peters, Ulrike, Poynter, Jenny N, Rinaldi, Sabina, Robien, Kim, Rohan, Thomas, Sandler, Dale P, Schairer, Catherine, Schouten, Leo J, Sjöholm, Louise K, Sieri, Sabina, Swerdlow, Anthony, Tjonneland, Anna, Travis, Ruth, Trichopoulou, Antonia, van den Brandt, Piet A, Wilkens, Lynne, Wolk, Alicja, Yang, Hannah P, Zeleniuch-Jacquotte, Anne, and Tworoger, Shelley S
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- 2016
77. Impact of Sex on the Survival of Patients With Hepatocellular Carcinoma: A Surveillance, Epidemiology, and End Results Analysis
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Yang, Dongyun, Hanna, Diana L., Usher, Josh, LoCoco, Jordan, Chaudhari, Pritesh, Lenz, Heinz-Josef, Setiawan, V. Wendy, and El-Khoueiry, Anthony
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Adult ,Male ,Carcinoma, Hepatocellular ,Adolescent ,Asian ,Liver Neoplasms ,Age Factors ,Hispanic or Latino ,Middle Aged ,Protective Factors ,Article ,White People ,Liver Transplantation ,Black or African American ,Cohort Studies ,Young Adult ,Sex Factors ,Risk Factors ,Hepatectomy ,Humans ,Female ,Aged ,Proportional Hazards Models ,Retrospective Studies ,SEER Program - Abstract
BACKGROUND: Men are 4 to 8 times more likely to develop hepatocellular carcinoma (HCC) than women. Preclinical models have suggested a role for sex hormones in the development of HCC. In the current study, the authors investigated the impact of age, sex, race, and ethnicity on the survival of patients with HCC using the Surveillance, Epidemiology, and End Results (SEER) database. METHODS: Patients diagnosed with HCC from 1988 through 2010 were identified from the SEER registry. Hazard ratios (HR) for overall survival (OS) were derived using the Cox regression model adjusted for race, year of diagnosis, marital status, treatment, birthplace, tumor differentiation, and tumor size. RESULTS: A total of 39,345 patients were identified; 76% were men and 34% were women (50% white, 12% African American, 21% Asian, 16% Hispanic, and 1% Native American). The median age at the time of diagnosis was 61 years for men and 67 years for women. Approximately 84% of patients had liver-limited disease and 16% had metastatic disease. Treatment information was available for patients diagnosed after 1998 (34,674 patients): 11% received liver-directed therapy, 11% underwent surgical resection, and 7% underwent liver transplantation. The HR for the OS of women versus men was 0.83 (95% confidence interval [95% CI], 0.77–0.88) for patients aged 65 years. CONCLUSIONS: Sex appears to be associated with survival in patients with HCC. The role of androgens and estrogens in the development and progression of HCC warrants further investigation.
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- 2014
78. Reply to High hepatocellular carcinoma risk among US-born Hispanics
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Setiawan, V. Wendy, primary, Wei, Pengxiao C., additional, Hernandez, Brenda Y., additional, Lu, Shelly C., additional, Monroe, Kristine R., additional, Marchand, Loic Le, additional, and Yuan, Jian Min, additional
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- 2016
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79. Ovarian Cancer Risk Factors by Histologic Subtype: An Analysis From the Ovarian Cancer Cohort Consortium
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Wentzensen, Nicolas, primary, Poole, Elizabeth M., additional, Trabert, Britton, additional, White, Emily, additional, Arslan, Alan A., additional, Patel, Alpa V., additional, Setiawan, V. Wendy, additional, Visvanathan, Kala, additional, Weiderpass, Elisabete, additional, Adami, Hans-Olov, additional, Black, Amanda, additional, Bernstein, Leslie, additional, Brinton, Louise A., additional, Buring, Julie, additional, Butler, Lesley M., additional, Chamosa, Saioa, additional, Clendenen, Tess V., additional, Dossus, Laure, additional, Fortner, Renee, additional, Gapstur, Susan M., additional, Gaudet, Mia M., additional, Gram, Inger T., additional, Hartge, Patricia, additional, Hoffman-Bolton, Judith, additional, Idahl, Annika, additional, Jones, Michael, additional, Kaaks, Rudolf, additional, Kirsh, Victoria, additional, Koh, Woon-Puay, additional, Lacey, James V., additional, Lee, I-Min, additional, Lundin, Eva, additional, Merritt, Melissa A., additional, Onland-Moret, N. Charlotte, additional, Peters, Ulrike, additional, Poynter, Jenny N., additional, Rinaldi, Sabina, additional, Robien, Kim, additional, Rohan, Thomas, additional, Sandler, Dale P., additional, Schairer, Catherine, additional, Schouten, Leo J., additional, Sjöholm, Louise K., additional, Sieri, Sabina, additional, Swerdlow, Anthony, additional, Tjonneland, Anna, additional, Travis, Ruth, additional, Trichopoulou, Antonia, additional, van den Brandt, Piet A., additional, Wilkens, Lynne, additional, Wolk, Alicja, additional, Yang, Hannah P., additional, Zeleniuch-Jacquotte, Anne, additional, and Tworoger, Shelley S., additional
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- 2016
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80. Metabolic stressors and pancreatic disease
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Pandol, Stephen, primary, Goodarzi, Mark, additional, Eibl, Guido, additional, Waldron, Richard, additional, Gukovskaya, Anna, additional, Monroe, Kristine, additional, Setiawan, V. Wendy, additional, Go, Vay Liang, additional, Ji, Baoan, additional, Edderkaoui, Mouad, additional, Afghani, Elham, additional, Goodman, Marc, additional, Jeon, Christie, additional, Wu, Bechien, additional, and Lugea, Aurelia, additional
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- 2016
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81. Ovarian cancer risk factors by histologic subtypes : evidence for etiologic heterogeneity
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Wentzensen, Nicolas A., Poole, Elizabeth, Arslan, Alan A., Patel, Alpa V., Setiawan, V. Wendy, Visvanathan, Kala, Weiderpass, Elisabete, White, Emily, Adami, Hans-Olov, Brinton, Louise A., Bernstein, Leslie, Buring, Julie, Butler, Lesley M., Chamosa, Saioa, Clendenen, Tess V., Dossus, Laure, Fortner, Renee, Gapstur, Susan M., Gaudet, Mia M., Gram, Inger Torhild, Hartge, Patricia, Hoffman-Bolton, Judith, Idahl, Annika, Jones, Michael, Kaaks, Rudolf, Kirsh, Vivki, Koh, Woon-Puay, Lacey, James V., Lee, I-Min, Lundin, Eva, Merritt, Melissa, Peters, Ulrike, Poynter, Jenny, Rinaldi, Sabina, Robien, Kim, Rohan, Thomas, Sandler, Dale P., Schouten, Leo J., Sjöholm, Louise, Sieri, Sabina, Swerdlow, Anthony, Tjønneland, Anne, Trabert, Britton, Wilkens, Lynne, Wolk, Alicja, Yang, Hannah P., Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S., Wentzensen, Nicolas A., Poole, Elizabeth, Arslan, Alan A., Patel, Alpa V., Setiawan, V. Wendy, Visvanathan, Kala, Weiderpass, Elisabete, White, Emily, Adami, Hans-Olov, Brinton, Louise A., Bernstein, Leslie, Buring, Julie, Butler, Lesley M., Chamosa, Saioa, Clendenen, Tess V., Dossus, Laure, Fortner, Renee, Gapstur, Susan M., Gaudet, Mia M., Gram, Inger Torhild, Hartge, Patricia, Hoffman-Bolton, Judith, Idahl, Annika, Jones, Michael, Kaaks, Rudolf, Kirsh, Vivki, Koh, Woon-Puay, Lacey, James V., Lee, I-Min, Lundin, Eva, Merritt, Melissa, Peters, Ulrike, Poynter, Jenny, Rinaldi, Sabina, Robien, Kim, Rohan, Thomas, Sandler, Dale P., Schouten, Leo J., Sjöholm, Louise, Sieri, Sabina, Swerdlow, Anthony, Tjønneland, Anne, Trabert, Britton, Wilkens, Lynne, Wolk, Alicja, Yang, Hannah P., Zeleniuch-Jacquotte, Anne, and Tworoger, Shelley S.
- Abstract
Supplement: 15 Meeting Abstract: 854
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- 2015
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82. Abstract 854: Ovarian cancer risk factors by histologic subtypes: evidence for etiologic heterogeneity
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Wentzensen, Nicolas A., primary, Poole, Elizabeth, additional, Arslan, Alan A., additional, Patel, Alpa V., additional, Setiawan, V Wendy, additional, Visvanathan, Kala, additional, Weiderpass, Elisabete, additional, White, Emily, additional, Adami, Hans-Olov, additional, Brinton, Louise A., additional, Bernstein, Leslie, additional, Buring, Julie, additional, Butler, Lesley M., additional, Chamosa, Saioa, additional, Clendenen, Tess V., additional, Dossus, Laure, additional, Fortner, Renee, additional, Gapstur, Susan M., additional, Gaudet, Mia M., additional, Gram, Inger Torhild, additional, Hartge, Patricia, additional, Hoffman-Bolton, Judith, additional, Idahl, Annika, additional, Jones, Michael, additional, Kaaks, Rudolf, additional, Kirsh, Vivki, additional, Koh, Woon-Puay, additional, Lacey, James V., additional, Lee, I-Min, additional, Lundin, Eva, additional, Merritt, Melissa, additional, Peters, Ulrike, additional, Poynter, Jenny, additional, Rinaldi, Sabina, additional, Robien, Kim, additional, Rohan, Thomas, additional, Sandler, Dale P., additional, Schouten, Leo J., additional, Sjöholm, Louise, additional, Sieri, Sabina, additional, Swerdlow, Anthony, additional, Tjønneland, Anne, additional, Trabert, Britton, additional, Wilkens, Lynne, additional, Wolk, Alicja, additional, Yang, Hannah P., additional, Zeleniuch-Jacquotte, Anne, additional, and Tworoger, Shelley S., additional
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- 2015
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83. Risk factors for endometrial cancer in black and white women: a pooled analysis from the epidemiology of endometrial cancer consortium (E2C2)
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Cote, Michele L., primary, Alhajj, Tala, additional, Ruterbusch, Julie J., additional, Bernstein, Leslie, additional, Brinton, Louise A., additional, Blot, William J., additional, Chen, Chu, additional, Gass, Margery, additional, Gaussoin, Sarah, additional, Henderson, Brian, additional, Lee, Eunjung, additional, Horn-Ross, Pamela L., additional, Kolonel, Laurence N., additional, Kaunitz, Andrew, additional, Liang, Xiaolin, additional, Nicholson, Wanda K., additional, Park, Amy B., additional, Petruzella, Stacey, additional, Rebbeck, Timothy R., additional, Setiawan, V. Wendy, additional, Signorello, Lisa B., additional, Simon, Michael S., additional, Weiss, Noel S., additional, Wentzensen, Nicolas, additional, Yang, Hannah P., additional, Zeleniuch-Jacquotte, Anne, additional, and Olson, Sara H., additional
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- 2014
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84. Sequence variants of estrogen receptor beta and risk of prostate cancer in the national cancer institute breast and prostate cancer cohort consortium
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Chen, Yen-Ching Kraft, Peter Bretsky, Philip Ketkar, Shamika and Hunter, David J. Albanes, Demetrius Altshuler, David and Andriole, Gerald Berg, Christine D. Boeing, Heiner Burtt, Noel Bueno-de-Mesquita, Bas Cann, Howard Canzian, Federico and Chanock, Stephen Dunning, Alison Feigelson, Heather S. and Freedman, Matthew Gaziano, J. Michael Giovannucci, Edward and Sanchez, Maria-Jose Haiman, Christopher A. Hallmans, Goran and Hayes, Richard B. Henderson, Brian E. Hirschhorn, Joel and Kaaks, Rudolf Key, Timothy J. Kolonel, Laurence N. and LeMarchand, Loic Ma, Jing Overvad, Kim Palli, Domenico and Pharaoh, Paul Pike, Malcolm Riboli, Eliot Rodriguez, Carmen and Setiawan, V. Wendy Stampfer, Meir Stram, Daniel O. and Thomas, Gilles Thun, Michael J. Travis, Ruth C. Virtamo, Jarmo Trichopouiou, Antonia Wacholder, Sholom Weinstein, Stephanie J.
- Abstract
Background: Estrogen receptor beta (ESR2) may play a role in modulating prostate carcirtogenesis through the regulation of genes related to cell proliferation and apoptosis. Methods: We conducted nested case-control studies in the Breast and Prostate Cancer Cohort Consortium (BPC3) that pooled 8,323 prostate cancer cases and 9,412 controls from seven cohorts. Whites were the predominant ethnic group. We characterized genetic variation in ESR2 by resequencing exons in 190 breast and prostate cancer cases and genotyping a dense set of single nucleotide polymorphisms (SNP) spanning the locus in a multiethnic panel of 349 cancer-free subjects. We selected four haplotype-tagging SNPs (htSNP) to capture common ESR2 variation in Whites; these htSNPs were then genotyped in all cohorts. Conditional logistic regression models were used to assess the association between sequence variants of ESR2 and the risk of prostate cancer. We also investigated the effect modification by age, body mass index, and family history, as well as the association between sequence variants of ESR2 and advanced-stage (>= T3b, N-1, or M-1) and high-grade (Gleason sum >= 8) prostate cancer, respectively. Results: The four tag SNPs in ESR2 were not significantly associated with prostate cancer risk, individually. The global test for the influence of any haplotype on the risk of prostate cancer was not significant (P = 0.31). However, we observed that men carrying two copies of one of the variant haplotypes (TACC) had a 1.46-fold increased risk of prostate cancer (99% confidence interval, 1.06-2.01) compared with men carrying zero copies of this variant haplotype. No SNPs or haplotypes were associated with advanced stage or high grade of prostate cancer. Conclusion: In our analysis focused on genetic variation common in Whites, we observed little evidence for any substantial association of inherited variation in ESR2 with risk of prostate cancer. A nominally significant (P < 0.01) association between the TACC haplotype and prostate cancer risk under the recessive model could be a chance finding and, in any event, would seem to contribute only slightly to the overall burden of prostate cancer.
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- 2007
85. Abstract 2167: Infertility and risk of incident endometrial carcinoma: a pooled analysis from the Epidemiology of Endometrial Cancer Consortium
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Yang, Hannah P., primary, Cook, Linda S., additional, Weiderpass, Elisabete, additional, Adami, Hans-Olov, additional, Anderson, Kristin E., additional, Cai, Hui, additional, Cerhan, James R., additional, Clendenen, Tess, additional, Felix, Ashley S., additional, Friedenreich, Christine, additional, Garcia-Closas, Montserrat, additional, Goodman, Marc T., additional, Liang, Xiaolin, additional, Lissowska, Jolanta, additional, Lu, Lingeng, additional, Magliocco, Anthony M., additional, McCann, Susan E., additional, Moysich, Kristen B., additional, Olson, Sara H., additional, Pike, Malcolm C., additional, Polidoro, Silvia, additional, Ricceri, Fulvio, additional, Risch, Harvey, additional, Sacerdote, Carlotta, additional, Setiawan, V. Wendy, additional, Shu, Xiao O., additional, Spurdle, Amanda B., additional, Trabert, Britton, additional, Webb, Penelope M., additional, Wentzensen, Nicolas, additional, Xiang, Yong-Bing, additional, Xu, Youming, additional, Yu, Herbert, additional, Zeleniuch-Jacquotte, Anne, additional, and Brinton, Louise A., additional
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- 2014
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86. Impact of sex on the survival of patients with hepatocellular carcinoma: A Surveillance, Epidemiology, and End Results analysis
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Yang, Dongyun, primary, Hanna, Diana L., additional, Usher, Josh, additional, LoCoco, Jordan, additional, Chaudhari, Pritesh, additional, Lenz, Heinz-Josef, additional, Setiawan, V. Wendy, additional, and El-Khoueiry, Anthony, additional
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- 2014
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87. Sequence variants of estrogen receptor beta and risk of prostate cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium.
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Chen, Yen-Ching, Kraft, Peter, Bretsky, Philip, Ketkar, Shamika, Hunter, David J, Albanes, Demetrius, Altshuler, David, Andriole, Gerald, Berg, Christine D, Boeing, Heiner, Burtt, Noel, Bueno-de-Mesquita, Bas, Cann, Howard, Canzian, Federico, Chanock, Stephen, Dunning, Alison, Feigelson, Heather S, Freedman, Matthew, Gaziano, J Michael, Giovannucci, Edward, Sánchez, Maria-Jose, Haiman, Christopher A, Hallmans, Göran, Hayes, Richard B, Henderson, Brian E, Hirschhorn, Joel, Kaaks, Rudolf, Key, Timothy J, Kolonel, Laurence N, LeMarchand, Loic, Ma, Jing, Overvad, Kim, Palli, Domenico, Pharaoh, Paul, Pike, Malcolm, Riboli, Eliot, Rodriguez, Carmen, Setiawan, V Wendy, Stampfer, Meir, Stram, Daniel O, Thomas, Gilles, Thun, Michael J, Travis, Ruth C, Virtamo, Jarmo, Trichopoulou, Antonia, Wacholder, Sholom, Weinstein, Stephanie J, Chen, Yen-Ching, Kraft, Peter, Bretsky, Philip, Ketkar, Shamika, Hunter, David J, Albanes, Demetrius, Altshuler, David, Andriole, Gerald, Berg, Christine D, Boeing, Heiner, Burtt, Noel, Bueno-de-Mesquita, Bas, Cann, Howard, Canzian, Federico, Chanock, Stephen, Dunning, Alison, Feigelson, Heather S, Freedman, Matthew, Gaziano, J Michael, Giovannucci, Edward, Sánchez, Maria-Jose, Haiman, Christopher A, Hallmans, Göran, Hayes, Richard B, Henderson, Brian E, Hirschhorn, Joel, Kaaks, Rudolf, Key, Timothy J, Kolonel, Laurence N, LeMarchand, Loic, Ma, Jing, Overvad, Kim, Palli, Domenico, Pharaoh, Paul, Pike, Malcolm, Riboli, Eliot, Rodriguez, Carmen, Setiawan, V Wendy, Stampfer, Meir, Stram, Daniel O, Thomas, Gilles, Thun, Michael J, Travis, Ruth C, Virtamo, Jarmo, Trichopoulou, Antonia, Wacholder, Sholom, and Weinstein, Stephanie J
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- 2007
88. Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women.
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Haiman, Christopher A, Dossus, Laure, Setiawan, V Wendy, Stram, Daniel O, Dunning, Alison M, Thomas, Gilles, Thun, Michael J, Albanes, Demetrius, Altshuler, David, Ardanaz, Eva, Boeing, Heiner, Buring, Julie, Burtt, Noël, Calle, Eugenia E, Chanock, Stephen, Clavel-Chapelon, Francoise, Colditz, Graham A, Cox, David G, Feigelson, Heather Spencer, Hankinson, Susan E, Hayes, Richard B, Henderson, Brian E, Hirschhorn, Joel N, Hoover, Robert, Hunter, David J, Kaaks, Rudolf, Kolonel, Laurence N, Le Marchand, Loic, Lenner, Per, Lund, Eiliv, Panico, Salvatore, Peeters, Petra H, Pike, Malcolm C, Riboli, Elio, Tjonneland, Anne, Travis, Ruth, Trichopoulos, Dimitrios, Wacholder, Sholom, Ziegler, Regina G, Haiman, Christopher A, Dossus, Laure, Setiawan, V Wendy, Stram, Daniel O, Dunning, Alison M, Thomas, Gilles, Thun, Michael J, Albanes, Demetrius, Altshuler, David, Ardanaz, Eva, Boeing, Heiner, Buring, Julie, Burtt, Noël, Calle, Eugenia E, Chanock, Stephen, Clavel-Chapelon, Francoise, Colditz, Graham A, Cox, David G, Feigelson, Heather Spencer, Hankinson, Susan E, Hayes, Richard B, Henderson, Brian E, Hirschhorn, Joel N, Hoover, Robert, Hunter, David J, Kaaks, Rudolf, Kolonel, Laurence N, Le Marchand, Loic, Lenner, Per, Lund, Eiliv, Panico, Salvatore, Peeters, Petra H, Pike, Malcolm C, Riboli, Elio, Tjonneland, Anne, Travis, Ruth, Trichopoulos, Dimitrios, Wacholder, Sholom, and Ziegler, Regina G
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- 2007
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89. Abstract 2787: Circulating 25-hydroxyvitamin D and risk of endometrial cancer: Results from the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers
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Zeleniuch-Jacquotte, Anne, primary, Gallicchio, Lisa, additional, Hartmuller, Virginia, additional, Helzlsouer, Kathy J., additional, Horst, Ronald, additional, McCullough, Marjorie L., additional, Setiawan, V. Wendy, additional, Shu, Xiao-Ou, additional, Weinstein, Stephanie J., additional, and Hankinson, Susan E., additional
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- 2010
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90. Sequence Variants of Estrogen Receptor β and Risk of Prostate Cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium
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Chen, Yen-Ching, primary, Kraft, Peter, additional, Bretsky, Philip, additional, Ketkar, Shamika, additional, Hunter, David J., additional, Albanes, Demetrius, additional, Altshuler, David, additional, Andriole, Gerald, additional, Berg, Christine D., additional, Boeing, Heiner, additional, Burtt, Noel, additional, Bueno-de-Mesquita, Bas, additional, Cann, Howard, additional, Canzian, Federico, additional, Chanock, Stephen, additional, Dunning, Alison, additional, Feigelson, Heather S., additional, Freedman, Matthew, additional, Gaziano, J. Michael, additional, Giovannucci, Edward, additional, Sánchez, Maria-Jose, additional, Haiman, Christopher A., additional, Hallmans, Göran, additional, Hayes, Richard B., additional, Henderson, Brian E., additional, Hirschhorn, Joel, additional, Kaaks, Rudolf, additional, Key, Timothy J., additional, Kolonel, Laurence N., additional, LeMarchand, Loic, additional, Ma, Jing, additional, Overvad, Kim, additional, Palli, Domenico, additional, Pharaoh, Paul, additional, Pike, Malcolm, additional, Riboli, Eliot, additional, Rodriguez, Carmen, additional, Setiawan, V. Wendy, additional, Stampfer, Meir, additional, Stram, Daniel O., additional, Thomas, Gilles, additional, Thun, Michael J., additional, Travis, Ruth C., additional, Virtamo, Jarmo, additional, Trichopoulou, Antonia, additional, Wacholder, Sholom, additional, and Weinstein, Stephanie J., additional
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- 2007
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91. A Variant in the Cytochrome P450 Oxidoreductase Gene Is Associated with Breast Cancer Risk in African Americans
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Haiman, Christopher A., primary, Setiawan, V. Wendy, additional, Xia, Lucy Y., additional, Le Marchand, Loïc, additional, Ingles, Sue A., additional, Ursin, Giske, additional, Press, Michael F., additional, Bernstein, Leslie, additional, John, Esther M., additional, and Henderson, Brian E., additional
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- 2007
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92. Genetic Variation at the CYP19A1 Locus Predicts Circulating Estrogen Levels but not Breast Cancer Risk in Postmenopausal Women
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Haiman, Christopher A., primary, Dossus, Laure, additional, Setiawan, V. Wendy, additional, Stram, Daniel O., additional, Dunning, Alison M., additional, Thomas, Gilles, additional, Thun, Michael J., additional, Albanes, Demetrius, additional, Altshuler, David, additional, Ardanaz, Eva, additional, Boeing, Heiner, additional, Buring, Julie, additional, Burtt, Noël, additional, Calle, Eugenia E., additional, Chanock, Stephen, additional, Clavel-Chapelon, Françoise, additional, Colditz, Graham A., additional, Cox, David G., additional, Feigelson, Heather Spencer, additional, Hankinson, Susan E., additional, Hayes, Richard B., additional, Henderson, Brian E., additional, Hirschhorn, Joel N., additional, Hoover, Robert, additional, Hunter, David J., additional, Kaaks, Rudolf, additional, Kolonel, Laurence N., additional, Le Marchand, Loïc, additional, Lenner, Per, additional, Lund, Eiliv, additional, Panico, Salvatore, additional, Peeters, Petra H., additional, Pike, Malcolm C., additional, Riboli, Elio, additional, Tjonneland, Anne, additional, Travis, Ruth, additional, Trichopoulos, Dimitrios, additional, Wacholder, Sholom, additional, and Ziegler, Regina G., additional
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- 2007
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93. Haplotype Analysis of the HSD17B1 Gene and Risk of Breast Cancer: A Comprehensive Approach to Multicenter Analyses of Prospective Cohort Studies
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Feigelson, Heather Spencer, primary, Cox, David G., additional, Cann, Howard M., additional, Wacholder, Sholom, additional, Kaaks, Rudolf, additional, Henderson, Brian E., additional, Albanes, Demetrius, additional, Altshuler, David, additional, Berglund, Goran, additional, Berrino, Franco, additional, Bingham, Sheila, additional, Buring, Julie E., additional, Burtt, Noel P., additional, Calle, Eugenia E., additional, Chanock, Stephen J., additional, Clavel-Chapelon, Francoise, additional, Colditz, Graham, additional, Diver, W. Ryan, additional, Freedman, Matthew L., additional, Haiman, Christopher A., additional, Hankinson, Susan E., additional, Hayes, Richard B., additional, Hirschhorn, Joel N., additional, Hunter, David, additional, Kolonel, Laurence N., additional, Kraft, Peter, additional, LeMarchand, Loic, additional, Linseisen, Jakob, additional, Modi, William, additional, Navarro, Carmen, additional, Peeters, Petra H., additional, Pike, Malcolm C., additional, Riboli, Elio, additional, Setiawan, V. Wendy, additional, Stram, Daniel O., additional, Thomas, Gilles, additional, Thun, Michael J., additional, Tjonneland, Anne, additional, and Trichopoulos, Dimitrios, additional
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- 2006
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94. Genetic variation in the progesterone receptor gene and risk of endometrial cancer: a haplotype-based approach.
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Eunjung Lee, Hsu, Chris, Haiman, Christopher A., Razavi, Pedram, Horn-Ross, Pamela L., Van Den Berg, David, Bernstein, Leslie, Le Marchand, Loic, Henderson, Brian E., Setiawan, V. Wendy, and Ursin, Giske
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HUMAN genetic variation ,PROGESTERONE ,CANCER risk factors ,OVARIAN cancer ,ENDOMETRIAL cancer - Abstract
Background: It is well established that estrogen increases endometrial cancer risk, whereas progesterone opposes the estrogen effects. The PROGINS allele of the progesterone receptor (PGR) gene reduces the function of PGR and has been associated with increased risk of the endometrioid type ovarian cancer. We investigated whether genetic variation in PGR is also associated with endometrial cancer risk using a haplotype-based approach. Methods: We pooled data from two endometrial cancer case–control studies that were nested within two prospective cohorts, the Multiethnic Cohort Study and the California Teachers Study. Seventeen haplotype-tagging single nucleotide polymorphisms (SNPs) across four linkage disequilibrium (LD) blocks spanning the PGR locus were genotyped in 583 incident cases and 1936 control women. Odds ratios (ORs) and 95% confidence intervals (CIs) associated with each haplotype were estimated using conditional logistic regression, stratified by age and ethnicity. Results: Genetic variation in LD block 3 of the PGR locus was associated with endometrial cancer risk (Pglobal test = 0.002), with haplotypes 3C, 3D and 3F associated with 31–34% increased risk. Among whites (383 cases/840 controls), genetic variation in all four blocks was associated with increased endometrial cancer risk (Pglobal test = 0.010, 0.013, 0.005 and 0.020). Haplotypes containing the PROGINS allele and several haplotypes in blocks 1, 3 and 4 were associated with 34–77% increased risk among whites. SNP analyses for whites suggested that rs608995, partially linked to the PROGINS allele (r2 = 0.6), was associated with increased risk (OR = 1.30, 95% CI = 1.06–1.59). Conclusions: Our results suggest that genetic variation in the PGR region is associated with endometrial cancer risk. [ABSTRACT FROM PUBLISHER]
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- 2010
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95. Genetics of chronic kidney disease stages across ancestries: The PAGE study
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Heiss, G., Graff, M., Setiawan, V. Wendy, Lin, B.M., Kooperberg, C., Carlson, C.S., Matise, T.C., Buyske, S., Wilkens, L.R., Franceschini, N., Ambite, J.L., Tao, R., Morris, A.P., North, K.E., Nadkarni, G.N., Boerwinkle, E., Loos, R.J.F., Wassel, C.L., Fornage, M., Lin, D.-Y., Lani Park, S., and Highland, H.M.
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3. Good health - Abstract
Background: Chronic kidney disease (CKD) is common and disproportionally burdens United States ethnic minorities. Its genetic determinants may differ by disease severity and clinical stages. To uncover genetic factors associated CKD severity among high-risk ethnic groups, we performed genome-wide association studies (GWAS) in diverse populations within the Population Architecture using Genomics and Epidemiology (PAGE) study. Methods: We assembled multi-ethnic genome-wide imputed data on CKD non-overlapping cases [4,150 mild to moderate CKD, 1,105 end-stage kidney disease (ESKD)] and non-CKD controls for up to 41,041 PAGE participants (African Americans, Hispanics/Latinos, East Asian, Native Hawaiian, and American Indians). We implemented a generalized estimating equation approach for GWAS using ancestry combined data while adjusting for age, sex, principal components, study, and ethnicity. Results: The GWAS identified a novel genome-wide associated locus for mild to moderate CKD nearby NMT2 (rs10906850, p = 3.7 × 10-8) that replicated in the United Kingdom Biobank white British (p = 0.008). Several variants at the APOL1 locus were associated with ESKD including the APOL1 G1 rs73885319 (p = 1.2 × 10-9). There was no overlap among associated loci for CKD and ESKD traits, even at the previously reported APOL1 locus (p = 0.76 for CKD). Several additional loci were associated with CKD or ESKD at p-values below the genome-wide threshold. These loci were often driven by variants more common in non-European ancestry. Conclusion: Our genetic study identified a novel association at NMT2 for CKD and showed for the first time strong associations of the APOL1 variants with ESKD across multi-ethnic populations. Our findings suggest differences in genetic effects across CKD severity and provide information for study design of genetic studies of CKD in diverse populations. Copyright © 2019 Lin, Nadkarni, Tao, Graff, Fornage, Buyske, Matise, Highland, Wilkens, Carlson, Park, Setiawan, Ambite, Heiss, Boerwinkle, Lin, Morris, Loos, Kooperberg, North, Wassel and Franceschini. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
96. Polygenic Risk Modelling for Prediction of Epithelial Ovarian Cancer Risk
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Dareng, Eileen O, Tyrer, Jonathan, Barnes, Daniel, Jones, Michelle R, Yang, Xin, Aben, Katja KH, Adank, Muriel A, Agata, Simona, Andrulis, Irene L, Anton-Culver, Hoda, Antonenkova, Natalia N, Aravantinos, Gerasimos, Arun, Banu K, Augustinsson, Annelie, Balma��a, Judith, Bandera, Elisa V, Barkardottir, Rosa B, Barrowdale, Daniel, Beckmann, Matthias W, Beeghly-Fadiel, Alicia, Benitez, Javier, Bermisheva, Marina, Bernardini, Marcus Q, Bjorge, Line, Black, Amanda, Bogdanova, Natalia V, Bonanni, Bernardo, Borg, Ake, Brenton, James, Budzilowska, Agnieszka, Butzow, Ralf, Buys, Saundra S, Cai, Hui, Caligo, Maria A, Campbell, Ian, Cannioto, Rikki, Cassingham, Hayley, Chang-Claude, Jenny, Chanock, Stephen J, Chen, Kexin, Chiew, Yoke-Eng, Chung, Wendy K, Claes, Kathleen BM, Colanna, Sarah, Cook, Linda S, Couch, Fergus J, Daly, Mary B, Dao, Fanny, Davies, Eleanor, De La Hoya, Miguel, Putter, Robin De, Dennis, Joe, DePersia, Allison, Devilee, Peter, Diez, Orland, Ding, Yuan Chun, Doherty, Jennifer A, Domchek, Susan M, D��rk, Thilo, Bois, Andreas Du, D��rst, Matthias, Eccles, Diana M, Eliassen, Heather A, Engel, Christoph, Evans, D Gareth, Fasching, Peter A, Flanagan, James M, Foretova, Lenka, Fortner, Ren��e T, Friedman, Eitan, Ganz, Patricia A, Garber, Judy, Gensini, Francesca, Giles, Graham G, Glendon, Gord, Godwin, Andrew K, Goodman, Marc T, Greene, Mark H, Gronwald, Jacek, Hahnen, Eric, Haiman, Christopher A, H��kansson, Niclas, Hamann, Ute, Hansen, Thomas VO, Harris, Holly R, Hartman, Mikael, Heitz, Florian, Hildebrandt, Michelle AT, H��gdall, Estrid, H��gdall, Claus K, Hopper, John L, Huang, Ruea-Yea, Huff, Chad, Hulick, Peter J, Huntsman, David G, Imyanitov, Evgeny N, Isaacs, Claudine, Jakubowska, Anna, James, Paul A, Janavicius, Ramunas, Jensen, Allan, Johannsson, Oskar Th, John, Esther M, Jones, Michael E, Kang, Daehee, Karlan, Beth Y, Karnezis, Anthony, Kelemen, Linda E, Khusnutdinova, Elza, Kiemeney, Lambertus A, Kim, Byoung-Gie, Kjaer, Susanne K, Komenaka, Ian, Kupryjanczyk, Jolanta, Kurian, Allison W, Kwong, Ava, Lambrechts, Diether, Larson, Melissa C, Lazaro, Conxi, Le, Nhu D, Leslie, Goska, Lester, Jenny, Lesueur, Fabienne, Levine, Douglas A, Li, Lian, Li, Jingmei, Loud, Jennifer T, Lu, Karen H, Lubi��ski, Jan, Machackova, Eva, Mai, Phuong L, Manoukian, Siranoush, Marks, Jeffrey R, Matsuno, Rayna Kim, Matsuo, Keitaro, May, Taymaa, McGuffog, Lesley, McLaughlin, John R, McNeish, Iain A, Mebirouk, Noura, Menon, Usha, Miller, Austin, Milne, Roger L, Minlikeeva, Albina, Modugno, Francesmary, Montagna, Marco, Moysich, Kirsten B, Munro, Elizabeth, Nathanson, Katherine L, Neuhausen, Susan L, Nevanlinna, Heli, Yie, Joanne Ngeow Yuen, Nielsen, Henriette Roed, Nielsen, Finn C, Nikitina-Zake, Liene, Odunsi, Kunle, Offit, Kenneth, Olah, Edith, Olbrecht, Siel, Olopade, Olufunmilayo I, Olson, Sara H, Olsson, H��kan, Osorio, Ana, Papi, Laura, Park, Sue K, Parsons, Michael T, Pathak, Harsha, Pedersen, Inge Sokilde, Peixoto, Ana, Pejovic, Tanja, Perez-Segura, Pedro, Permuth, Jennifer B, Peshkin, Beth, Peterlongo, Paolo, Piskorz, Anna, Prokofyeva, Darya, Radice, Paolo, Rantala, Johanna, Riggan, Marjorie J, Risch, Harvey A, Rodriguez-Antona, Cristina, Ross, Eric, Rossing, Mary Anne, Runnebaum, Ingo, Sandler, Dale P, Santamari��a, Marta, Soucy, Penny, Schmutzler, Rita K, Setiawan, V Wendy, Shan, Kang, Sieh, Weiva, Simard, Jacques, Singer, Christian F, Sokolenko, Anna P, Song, Honglin, Southey, Melissa C, Steed, Helen, Stoppa-Lyonnet, Dominique, Sutphen, Rebecca, Swerdlow, Anthony J, Tan, Yen Yen, Teixeira, Manuel R, Teo, Soo Hwang, Terry, Kathryn L, Terry, Mary Beth, Thomassen, Mads, Thompson, Pamela J, Vestrheim Thomsen, Liv Cecilie, Thull, Darcy L, Tischkowitz, Marc, Titus, Linda, Toland, Amanda E, Torres, Diana, Trabert, Britton, Travis, Ruth, Tung, Nadine, Tworoger, Shelley S, Valen, Ellen, Van Altena, Anne M, Van Der Hout, Annemieke H, Van Nieuwenhuysen, Els, Van Rensburg, Elizabeth J, Vega, Ana, Edwards, Digna Velez, Vierkant, Robert A, Wang, Frances, Wappenschmidt, Barbara, Webb, Penelope M, Weinberg, Clarice R, Weitzel, Jeffrey N, Wentzensen, Nicolas, White, Emily, Whittemore, Alice S, Winham, Stacey J, Wolk, Alicja, Woo, Yin-Ling, Wu, Anna H, Yan, Li, Yannoukakos, Drakoulis, Zavaglia, Katia M, Zheng, Wei, Ziogas, Argyrios, Zorn, Kristin K, Easton, Douglas, Lawrenson, Kate, DeFazio, Anna, Sellers, Thomas A, Ramus, Susan J, Pearce, Celeste L, Monteiro, Alvaro N, Cunningham, Julie, Goode, Ellen L, Schildkraut, Joellen M, Berchuck, Andrew, Chenevix-Trench, Georgia, Gayther, Simon A, Antoniou, Antonis C, and Pharoah, Paul DP
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3. Good health - Abstract
Polygenic risk scores (PRS) for epithelial ovarian cancer (EOC) have the potential to improve risk stratification. Joint estimation of Single Nucleotide Polymorphism (SNP) effects in models could improve predictive performance over standard approaches of PRS construction. Here, we implemented computationally-efficient, penalized, logistic regression models (lasso, elastic net, stepwise) to individual level genotype data and a Bayesian framework with continuous shrinkage, ���select and shrink for summary statistics��� (S4), to summary level data for epithelial non-mucinous ovarian cancer risk prediction. We developed the models in a dataset consisting of 23,564 non-mucinous EOC cases and 40,138 controls participating in the Ovarian Cancer Association Consortium (OCAC) and validated the best models in three populations of different ancestries: prospective data from 198,101 women of European ancestry; 7,669 women of East Asian ancestry; 1,072 women of African ancestry, and in 18,915 BRCA1 and 12,337 BRCA2 pathogenic variant carriers of European ancestry. In the external validation data, the model with the strongest association for non-mucinous EOC risk derived from the OCAC model development data was the S4 model (27,240 SNPs) with odds ratios (OR) of 1.38(95%CI:1.28���1.48,AUC:0.588) per unit standard deviation, in women of European ancestry; 1.14(95%CI:1.08���1.19,AUC:0.538) in women of East Asian ancestry; 1.38(95%CI:1.21-1.58,AUC:0.593) in women of African ancestry; hazard ratios of 1.37(95%CI:1.30���1.44,AUC:0.592) in BRCA1 pathogenic variant carriers and 1.51(95%CI:1.36-1.67,AUC:0.624) in BRCA2 pathogenic variant carriers. Incorporation of the S4 PRS in risk prediction models for ovarian cancer may have clinical utility in ovarian cancer prevention programs.
97. Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer
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Kho, Pik-Fang, Amant, Frederic, Annibali, Daniela, Ashton, Katie, Attia, John, Auer, Paul L, Beckmann, Matthias W, Black, Amanda, Brinton, Louise, Buchanan, Daniel D, Chanock, Stephen J, Chen, Chu, Chen, Maxine M, Cheng, Timothy HT, Cook, Linda S, Crous-Bous, Marta, Czene, Kamila, De Vivo, Immaculata, Dennis, Joe, Dörk, Thilo, Dowdy, Sean C, Dunning, Alison M, Dürst, Matthias, Easton, Douglas F, Ekici, Arif B, Fasching, Peter A, Fridley, Brooke L, Friedenreich, Christine M, García-Closas, Montserrat, Gaudet, Mia M, Giles, Graham G, Goode, Ellen L, Gorman, Maggie, Haiman, Christopher A, Hall, Per, Hankinson, Susan E, Hein, Alexander, Hillemanns, Peter, Hodgson, Shirley, Hoivik, Erling A, Holliday, Elizabeth G, Hunter, David J, Jones, Angela, Kraft, Peter, Krakstad, Camilla, Lambrechts, Diether, Le Marchand, Loic, Liang, Xiaolin, Lindblom, Annika, Lissowska, Jolanta, Long, Jirong, Lu, Lingeng, Magliocco, Anthony M, Martin, Lynn, McEvoy, Mark, Milne, Roger L, Mints, Miriam, Nassir, Rami, Otton, Geoffrey, Palles, Claire, Pooler, Loreall, Proietto, Tony, Rebbeck, Timothy R, Renner, Stefan P, Risch, Harvey A, Rübner, Matthias, Runnebaum, Ingo, Sacerdote, Carlotta, Sarto, Gloria E, Schumacher, Fredrick, Scott, Rodney J, Setiawan, V Wendy, Shah, Mitul, Sheng, Xin, Shu, Xiao-Ou, Southey, Melissa C, Tham, Emma, Tomlinson, Ian, Trovik, Jone, Turman, Constance, Tyrer, Jonathan P, Van Den Berg, David, Wang, Zhaoming, Wentzensen, Nicolas, Xia, Lucy, Xiang, Yong-Bing, Yang, Hannah P, Yu, Herbert, Zheng, Wei, Webb, Penelope M, Thompson, Deborah J, Spurdle, Amanda B, Glubb, Dylan M, and O'Mara, Tracy A
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2. Zero hunger ,Risk ,Cholesterol, HDL ,endometrial cancer risk ,Cholesterol, LDL ,Mendelian Randomization Analysis ,3. Good health ,Endometrial Neoplasms ,HDL cholesterol ,Case-Control Studies ,LDL cholesterol ,Mendelian randomization ,Humans ,lipids (amino acids, peptides, and proteins) ,Female ,triglycerides ,Genome-Wide Association Study - Abstract
Blood lipids have been associated with the development of a range of cancers, including breast, lung and colorectal cancer. For endometrial cancer, observational studies have reported inconsistent associations between blood lipids and cancer risk. To reduce biases from unmeasured confounding, we performed a bidirectional, two-sample Mendelian randomization analysis to investigate the relationship between levels of three blood lipids (low-density lipoprotein [LDL] and high-density lipoprotein [HDL] cholesterol, and triglycerides) and endometrial cancer risk. Genetic variants associated with each of these blood lipid levels (P < 5 × 10-8 ) were identified as instrumental variables, and assessed using genome-wide association study data from the Endometrial Cancer Association Consortium (12 906 cases and 108 979 controls) and the Global Lipids Genetic Consortium (n = 188 578). Mendelian randomization analyses found genetically raised LDL cholesterol levels to be associated with lower risks of endometrial cancer of all histologies combined, and of endometrioid and non-endometrioid subtypes. Conversely, higher genetically predicted HDL cholesterol levels were associated with increased risk of non-endometrioid endometrial cancer. After accounting for the potential confounding role of obesity (as measured by genetic variants associated with body mass index), the association between genetically predicted increased LDL cholesterol levels and lower endometrial cancer risk remained significant, especially for non-endometrioid endometrial cancer. There was no evidence to support a role for triglycerides in endometrial cancer development. Our study supports a role for LDL and HDL cholesterol in the development of non-endometrioid endometrial cancer. Further studies are required to understand the mechanisms underlying these findings.
98. Shared heritability and functional enrichment across six solid cancers
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Jiang, Xia, Finucane, Hilary K, Schumacher, Fredrick R, Schmit, Stephanie L, Tyrer, Jonathan P, Han, Younghun, Michailidou, Kyriaki, Lesseur, Corina, Kuchenbaecker, Karoline B, Dennis, Joe, Conti, David V, Casey, Graham, Gaudet, Mia M, Huyghe, Jeroen R, Albanes, Demetrius, Aldrich, Melinda C, Andrew, Angeline S, Andrulis, Irene L, Anton-Culver, Hoda, Antoniou, Antonis C, Antonenkova, Natalia N, Arnold, Susanne M, Aronson, Kristan J, Arun, Banu K, Bandera, Elisa V, Barkardottir, Rosa B, Barnes, Daniel R, Batra, Jyotsna, Beckmann, Matthias W, Benitez, Javier, Benlloch, Sara, Berchuck, Andrew, Berndt, Sonja I, Bickeböller, Heike, Bien, Stephanie A, Blomqvist, Carl, Boccia, Stefania, Bogdanova, Natalia V, Bojesen, Stig E, Bolla, Manjeet K, Brauch, Hiltrud, Brenner, Hermann, Brenton, James D, Brook, Mark N, Brunet, Joan, Brunnström, Hans, Buchanan, Daniel D, Burwinkel, Barbara, Butzow, Ralf, Cadoni, Gabriella, Caldés, Trinidad, Caligo, Maria A, Campbell, Ian, Campbell, Peter T, Cancel-Tassin, Géraldine, Cannon-Albright, Lisa, Campa, Daniele, Caporaso, Neil, Carvalho, André L, Chan, Andrew T, Chang-Claude, Jenny, Chanock, Stephen J, Chen, Chu, Christiani, David C, Claes, Kathleen BM, Claessens, Frank, Clements, Judith, Collée, J Margriet, Correa, Marcia Cruz, Couch, Fergus J, Cox, Angela, Cunningham, Julie M, Cybulski, Cezary, Czene, Kamila, Daly, Mary B, DeFazio, Anna, Devilee, Peter, Diez, Orland, Gago-Dominguez, Manuela, Donovan, Jenny L, Dörk, Thilo, Duell, Eric J, Dunning, Alison M, Dwek, Miriam, Eccles, Diana M, Edlund, Christopher K, Edwards, Digna R Velez, Ellberg, Carolina, Evans, D Gareth, Fasching, Peter A, Ferris, Robert L, Liloglou, Triantafillos, Figueiredo, Jane C, Fletcher, Olivia, Fortner, Renée T, Fostira, Florentia, Franceschi, Silvia, Friedman, Eitan, Gallinger, Steven J, Ganz, Patricia A, Garber, Judy, García-Sáenz, José A, Gayther, Simon A, Giles, Graham G, Godwin, Andrew K, Goldberg, Mark S, Goldgar, David E, Goode, Ellen L, Goodman, Marc T, Goodman, Gary, Grankvist, Kjell, Greene, Mark H, Gronberg, Henrik, Gronwald, Jacek, Guénel, Pascal, Håkansson, Niclas, Hall, Per, Hamann, Ute, Hamdy, Freddie C, Hamilton, Robert J, Hampe, Jochen, Haugen, Aage, Heitz, Florian, Herrero, Rolando, Hillemanns, Peter, Hoffmeister, Michael, Høgdall, Estrid, Hong, Yun-Chul, Hopper, John L, Houlston, Richard, Hulick, Peter J, Hunter, David J, Huntsman, David G, Idos, Gregory, Imyanitov, Evgeny N, Ingles, Sue Ann, Isaacs, Claudine, Jakubowska, Anna, James, Paul, Jenkins, Mark A, Johansson, Mattias, Johansson, Mikael, John, Esther M, Joshi, Amit D, Kaneva, Radka, Karlan, Beth Y, Kelemen, Linda E, Kühl, Tabea, Khaw, Kay-Tee, Khusnutdinova, Elza, Kibel, Adam S, Kiemeney, Lambertus A, Kim, Jeri, Kjaer, Susanne K, Knight, Julia A, Kogevinas, Manolis, Kote-Jarai, Zsofia, Koutros, Stella, Kristensen, Vessela N, Kupryjanczyk, Jolanta, Lacko, Martin, Lam, Stephan, Lambrechts, Diether, Landi, Maria Teresa, Lazarus, Philip, Le, Nhu D, Lee, Eunjung, Lejbkowicz, Flavio, Lenz, Heinz-Josef, Leslie, Goska, Lessel, Davor, Lester, Jenny, Levine, Douglas A, Li, Li, Li, Christopher I, Lindblom, Annika, Lindor, Noralane M, Liu, Geoffrey, Loupakis, Fotios, Lubiński, Jan, Maehle, Lovise, Maier, Christiane, Mannermaa, Arto, Marchand, Loic Le, Margolin, Sara, May, Taymaa, McGuffog, Lesley, Meindl, Alfons, Middha, Pooja, Miller, Austin, Milne, Roger L, MacInnis, Robert J, Modugno, Francesmary, Montagna, Marco, Moreno, Victor, Moysich, Kirsten B, Mucci, Lorelei, Muir, Kenneth, Mulligan, Anna Marie, Nathanson, Katherine L, Neal, David E, Ness, Andrew R, Neuhausen, Susan L, Nevanlinna, Heli, Newcomb, Polly A, Newcomb, Lisa F, Nielsen, Finn Cilius, Nikitina-Zake, Liene, Nordestgaard, Børge G, Nussbaum, Robert L, Offit, Kenneth, Olah, Edith, Olama, Ali Amin Al, Olopade, Olufunmilayo I, Olshan, Andrew F, Olsson, Håkan, Osorio, Ana, Pandha, Hardev, Park, Jong Y, Pashayan, Nora, Parsons, Michael T, Pejovic, Tanja, Penney, Kathryn L, Peters, Wilbert HM, Phelan, Catherine M, Phipps, Amanda I, Plaseska-Karanfilska, Dijana, Pring, Miranda, Prokofyeva, Darya, Radice, Paolo, Stefansson, Kari, Ramus, Susan J, Raskin, Leon, Rennert, Gad, Rennert, Hedy S, Van Rensburg, Elizabeth J, Riggan, Marjorie J, Risch, Harvey A, Risch, Angela, Roobol, Monique J, Rosenstein, Barry S, Rossing, Mary Anne, De Ruyck, Kim, Saloustros, Emmanouil, Sandler, Dale P, Sawyer, Elinor J, Schabath, Matthew B, Schleutker, Johanna, Schmidt, Marjanka K, Setiawan, V Wendy, Shen, Hongbing, Siegel, Erin M, Sieh, Weiva, Singer, Christian F, Slattery, Martha L, Sorensen, Karina Dalsgaard, Southey, Melissa C, Spurdle, Amanda B, Stanford, Janet L, Stevens, Victoria L, Stintzing, Sebastian, Stone, Jennifer, Sundfeldt, Karin, Sutphen, Rebecca, Swerdlow, Anthony J, Tajara, Eloiza H, Tangen, Catherine M, Tardon, Adonina, Taylor, Jack A, Teare, M Dawn, Teixeira, Manuel R, Terry, Mary Beth, Terry, Kathryn L, Thibodeau, Stephen N, Thomassen, Mads, Bjørge, Line, Tischkowitz, Marc, Toland, Amanda E, Torres, Diana, Townsend, Paul A, Travis, Ruth C, Tung, Nadine, Tworoger, Shelley S, Ulrich, Cornelia M, Usmani, Nawaid, Vachon, Celine M, Van Nieuwenhuysen, Els, Vega, Ana, Aguado-Barrera, Miguel Elías, Wang, Qin, Webb, Penelope M, Weinberg, Clarice R, Weinstein, Stephanie, Weissler, Mark C, Weitzel, Jeffrey N, West, Catharine ML, White, Emily, Whittemore, Alice S, Wichmann, H-Erich, Wiklund, Fredrik, Winqvist, Robert, Wolk, Alicja, Woll, Penella, Woods, Michael, Wu, Anna H, Wu, Xifeng, Yannoukakos, Drakoulis, Zheng, Wei, Zienolddiny, Shanbeh, Ziogas, Argyrios, Zorn, Kristin K, Lane, Jacqueline M, Saxena, Richa, Thomas, Duncan, Hung, Rayjean J, Diergaarde, Brenda, McKay, James, Peters, Ulrike, Hsu, Li, García-Closas, Montserrat, Eeles, Rosalind A, Chenevix-Trench, Georgia, Brennan, Paul J, Haiman, Christopher A, Simard, Jacques, Easton, Douglas F, Gruber, Stephen B, Pharoah, Paul DP, Price, Alkes L, Pasaniuc, Bogdan, Amos, Christopher I, Kraft, Peter, and Lindström, Sara
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Male ,Ovarian Neoplasms ,Lung Neoplasms ,Mental Disorders ,Smoking ,Inheritance Patterns ,Prostatic Neoplasms ,Breast Neoplasms ,Polymorphism, Single Nucleotide ,White People ,3. Good health ,Neoplasm Proteins ,Phenotype ,Head and Neck Neoplasms ,Case-Control Studies ,Humans ,Female ,Genetic Predisposition to Disease ,Colorectal Neoplasms ,Genome-Wide Association Study - Abstract
Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10-8), breast and ovarian cancer (rg = 0.24, p = 7 × 10-5), breast and lung cancer (rg = 0.18, p =1.5 × 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.
99. Polygenic risk modeling for prediction of epithelial ovarian cancer risk
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Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética Humana, Torres-López, Diana María, Dareng, Eileen O., Tyrer, Jonathan P., Barnes, Daniel R., Jones. Michelle R., Yang, Xin, Aben, Katja K. H., Adank, Muriel A., Agata, Simona, Andrulis, Irene L., Anton-Culver, Hoda, Antonenkova, Natalia N., Aravantinos, Gerasimos, Arun, Banu K., Augustinsson, Annelie, Balmaña, Judith, Bandera, Elisa V., Barkardottir, Rosa B., Barrowdale, Daniel, Beckmann, Matthias W., Beeghly-Fadiel, Alicia, Benitez, Javier, Bermisheva, Marina, Bernardini, Marcus Q., Bjorge, Line, Black, Amanda, Bogdanova, Natalia V., Bonanni, Bernardo, Borg, Ake, Brenton, James D., Budzilowska, Agnieszka, Butzow, Ralf, Buys, Saundra S., Cai, Hui, Caligo, Maria A., Campbell, Ian, Cannioto, Rikki, Cassingham, Hayley, Chang-Claude, Jenny, Chanock, Stephen J., Chen, Kexin, Chiew, Yoke-Eng, Chung, Wendy K., Claes, Kathleen B. M., Colonna, Sarah, EMO Study Collaborators, GC-HBOC Study Collaborators, EMBRACE Collaborators, Cook, Linda S., Couch, Fergus J., Daly, Mary B., Dao, Fanny, Davies, Eleanor, de la Hoya, Miguel, de Putter, Robin, Dennis, Joe, DePersia, Allison, Devilee, Peter, Diez, Orland, Chun Ding, Yuan, Doherty, Jennifer A., Domchek, Susan M., Dörk, Thilo, du Bois, Andreas, Dürst, Matthias, Eccles, Diana M., Eliassen, Heather A., Engel, Christoph, Evans, Gareth D., Fasching, Peter A., Flanagan, James M., Fortner, Renée T., Machackova, Eva, Friedman, Eitan, Ganz, Patricia A., Garber, Judy, Gensini, Francesca, Giles, Graham G., Glendon, Gord, Godwin, Andrew K., Goodman, Marc T., Greene, Mark H., Gronwald, Jacek, OPAL Study Group, AOCS Group, Hahnen, Eric, Haiman, Christopher A., Håkansson, Niclas, Hamann, Ute, Hansen, Thomas V. O., Harris, Holly R., Hartman, Mikael, Heitz, Florian, Hildebrandt, Michelle A. T., Høgdall, Estrid, Høgdall, Claus K., Hopper, John L., Huang, Ruea-Yea, Huff, Chad, Hulick, Peter J., Huntsman, David G., Imyanitov, Evgeny N., KConFab Investigators, HEBON Investigators, Isaacs, Claudine, Jakubowska, Anna, James, Paul A., Janavicius, Ramunas, Jensen, Allan, Johannsson, Oskar Th., John, Esther M., Jones, Michael E., Kang, Daehee, Karlan, Beth Y., Karnezis, Anthony, Kelemen, Linda E., Khusnutdinova, Elza, Kiemeney, Lambertus A., Kim, Byoung-Gie, Kjaer, Susanne K., Komenaka, Ian, Kupryjanczyk, Jolanta, Kurian, Allison W., Kwong, Ava, Lambrechts, Diether, Larson, Melissa C., Lazaro, Conxi, Le, Nhu D., Leslie, Goska, Lester, Jenny, Lesueur, Fabienne, Levine, Douglas A., Li, Lian, Li, Jingmei, Loud, Jennifer T., Lu, Karen H., Lubiński, Jan, Mai, Phuong L., Manoukian, Siranoush, Marks, Jeffrey R., Matsuno, Rayna Kim, Matsuo, Keitaro, May, Taymaa, McGuffog, Lesley, McLaughlin, John R., McNeish, Iain A., Mebirouk, Noura, Menon, Usha, Miller, Austin, Milne, Roger L., Minlikeeva, Albina, Modugno, Francesmary, Montagna, Marco, Moysich, Kirsten B., Munro, Elizabeth, Nathanson, Katherine L., Neuhausen, Susan L., Nevanlinna, Heli, Ngeow Yuen, Yie Joanne, Nielsen, Henriette Roed, Nielsen, Finn C., Nikitina-Zake, Liene, Odunsi, Kunle, Offit, Kenneth, Olah, Edith, Olbrecht, Siel, Olopade, Olufunmilayo I., Olson, Sara H., Olsson, Håkan, Osorio, Ana, Papi, Laura, Park, Sue K., Parsons, Michael T., Pathak, Harsha, Sokilde Pedersen, Inge, Peixoto, Ana, Pejovic, Tanja, Perez-Segura, Pedro, Permuth, Jennifer B., Peshkin, Beth, Peterlongo, Paolo, Piskorz, Anna, Prokofyeva, Darya, Radice, Paolo, Rantala, Johanna, Riggan, Marjorie J., Risch, Harvey A., Rodriguez-Antona, Cristina, Ross, Eric, Rossing, Mary Anne, Runnebaum, Ingo, Sandler, Dale P., Santamariña, Marta, Soucy, Penny, Schmutzler, Rita K., Setiawan, V. Wendy, Shan, Kang, Sieh, Weiva, Simard, Jacques, Singer, Christian F., Sokolenko, Anna P., Song, Honglin, Southey, Melissa C., Steed, Helen, Stoppa-Lyonnet, Dominique, Sutphen, Rebecca, Swerdlow, Anthony J., Tan, Yen Yen, Teixeira, Manuel R., Teo, Soo Hwang, Terry, Kathryn L., Terry, Mary Beth, The OCAC Consortium, The CIMBA Consortium, Thomassen, Mads, Thompson, Pamela J., Vestrheim Thomsen, Liv Cecilie, Thull, Darcy L., Tischkowitz, Marc, Titus, Linda, Toland, Amanda E., Trabert, Britton, Travis, Ruth, Tung, Nadine, Tworoger, Shelley S., Valen, Ellen, van Altena, Anne M., van der Hout, Annemieke H., Van Nieuwenhuysen, Els, van Rensburg, Elizabeth J., Vega, Ana, Velez Edwards, Digna, Vierkant, Robert A., Wang, Frances, Wappenschmidt, Barbara, Webb, Penelope M., Weinberg, Clarice R., Weitzel, Jeffrey N., Wentzensen, Nicolas, White, Emily, Whittemore, Alice S., Winham, Stacey J., Wolk, Alicja, Woo, Yin-Ling, Wu, Anna H., Yan, Li, Yannoukakos, Drakoulis, Zavaglia, Katia M., Zheng, Wei, Ziogas, Argyrios, Zorn, Kristin K., Kleibl, Zdenek, Easton, Douglas, Lawrenson, Kate, DeFazio, Anna, Sellers, Thomas A., Ramus, Susan J., Pearce, Celeste L., Monteiro, Alvaro N., Cunningham, Julie, Goode, Ellen L., Schildkraut, Joellen M., Berchuck, Andrew, Chenevix-Trench, Georgia, Gayther, Simon A., Antoniou, Antonis C., Pharoah, Paul D. P., Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética Humana, Torres-López, Diana María, Dareng, Eileen O., Tyrer, Jonathan P., Barnes, Daniel R., Jones. Michelle R., Yang, Xin, Aben, Katja K. H., Adank, Muriel A., Agata, Simona, Andrulis, Irene L., Anton-Culver, Hoda, Antonenkova, Natalia N., Aravantinos, Gerasimos, Arun, Banu K., Augustinsson, Annelie, Balmaña, Judith, Bandera, Elisa V., Barkardottir, Rosa B., Barrowdale, Daniel, Beckmann, Matthias W., Beeghly-Fadiel, Alicia, Benitez, Javier, Bermisheva, Marina, Bernardini, Marcus Q., Bjorge, Line, Black, Amanda, Bogdanova, Natalia V., Bonanni, Bernardo, Borg, Ake, Brenton, James D., Budzilowska, Agnieszka, Butzow, Ralf, Buys, Saundra S., Cai, Hui, Caligo, Maria A., Campbell, Ian, Cannioto, Rikki, Cassingham, Hayley, Chang-Claude, Jenny, Chanock, Stephen J., Chen, Kexin, Chiew, Yoke-Eng, Chung, Wendy K., Claes, Kathleen B. M., Colonna, Sarah, EMO Study Collaborators, GC-HBOC Study Collaborators, EMBRACE Collaborators, Cook, Linda S., Couch, Fergus J., Daly, Mary B., Dao, Fanny, Davies, Eleanor, de la Hoya, Miguel, de Putter, Robin, Dennis, Joe, DePersia, Allison, Devilee, Peter, Diez, Orland, Chun Ding, Yuan, Doherty, Jennifer A., Domchek, Susan M., Dörk, Thilo, du Bois, Andreas, Dürst, Matthias, Eccles, Diana M., Eliassen, Heather A., Engel, Christoph, Evans, Gareth D., Fasching, Peter A., Flanagan, James M., Fortner, Renée T., Machackova, Eva, Friedman, Eitan, Ganz, Patricia A., Garber, Judy, Gensini, Francesca, Giles, Graham G., Glendon, Gord, Godwin, Andrew K., Goodman, Marc T., Greene, Mark H., Gronwald, Jacek, OPAL Study Group, AOCS Group, Hahnen, Eric, Haiman, Christopher A., Håkansson, Niclas, Hamann, Ute, Hansen, Thomas V. O., Harris, Holly R., Hartman, Mikael, Heitz, Florian, Hildebrandt, Michelle A. T., Høgdall, Estrid, Høgdall, Claus K., Hopper, John L., Huang, Ruea-Yea, Huff, Chad, Hulick, Peter J., Huntsman, David G., Imyanitov, Evgeny N., KConFab Investigators, HEBON Investigators, Isaacs, Claudine, Jakubowska, Anna, James, Paul A., Janavicius, Ramunas, Jensen, Allan, Johannsson, Oskar Th., John, Esther M., Jones, Michael E., Kang, Daehee, Karlan, Beth Y., Karnezis, Anthony, Kelemen, Linda E., Khusnutdinova, Elza, Kiemeney, Lambertus A., Kim, Byoung-Gie, Kjaer, Susanne K., Komenaka, Ian, Kupryjanczyk, Jolanta, Kurian, Allison W., Kwong, Ava, Lambrechts, Diether, Larson, Melissa C., Lazaro, Conxi, Le, Nhu D., Leslie, Goska, Lester, Jenny, Lesueur, Fabienne, Levine, Douglas A., Li, Lian, Li, Jingmei, Loud, Jennifer T., Lu, Karen H., Lubiński, Jan, Mai, Phuong L., Manoukian, Siranoush, Marks, Jeffrey R., Matsuno, Rayna Kim, Matsuo, Keitaro, May, Taymaa, McGuffog, Lesley, McLaughlin, John R., McNeish, Iain A., Mebirouk, Noura, Menon, Usha, Miller, Austin, Milne, Roger L., Minlikeeva, Albina, Modugno, Francesmary, Montagna, Marco, Moysich, Kirsten B., Munro, Elizabeth, Nathanson, Katherine L., Neuhausen, Susan L., Nevanlinna, Heli, Ngeow Yuen, Yie Joanne, Nielsen, Henriette Roed, Nielsen, Finn C., Nikitina-Zake, Liene, Odunsi, Kunle, Offit, Kenneth, Olah, Edith, Olbrecht, Siel, Olopade, Olufunmilayo I., Olson, Sara H., Olsson, Håkan, Osorio, Ana, Papi, Laura, Park, Sue K., Parsons, Michael T., Pathak, Harsha, Sokilde Pedersen, Inge, Peixoto, Ana, Pejovic, Tanja, Perez-Segura, Pedro, Permuth, Jennifer B., Peshkin, Beth, Peterlongo, Paolo, Piskorz, Anna, Prokofyeva, Darya, Radice, Paolo, Rantala, Johanna, Riggan, Marjorie J., Risch, Harvey A., Rodriguez-Antona, Cristina, Ross, Eric, Rossing, Mary Anne, Runnebaum, Ingo, Sandler, Dale P., Santamariña, Marta, Soucy, Penny, Schmutzler, Rita K., Setiawan, V. Wendy, Shan, Kang, Sieh, Weiva, Simard, Jacques, Singer, Christian F., Sokolenko, Anna P., Song, Honglin, Southey, Melissa C., Steed, Helen, Stoppa-Lyonnet, Dominique, Sutphen, Rebecca, Swerdlow, Anthony J., Tan, Yen Yen, Teixeira, Manuel R., Teo, Soo Hwang, Terry, Kathryn L., Terry, Mary Beth, The OCAC Consortium, The CIMBA Consortium, Thomassen, Mads, Thompson, Pamela J., Vestrheim Thomsen, Liv Cecilie, Thull, Darcy L., Tischkowitz, Marc, Titus, Linda, Toland, Amanda E., Trabert, Britton, Travis, Ruth, Tung, Nadine, Tworoger, Shelley S., Valen, Ellen, van Altena, Anne M., van der Hout, Annemieke H., Van Nieuwenhuysen, Els, van Rensburg, Elizabeth J., Vega, Ana, Velez Edwards, Digna, Vierkant, Robert A., Wang, Frances, Wappenschmidt, Barbara, Webb, Penelope M., Weinberg, Clarice R., Weitzel, Jeffrey N., Wentzensen, Nicolas, White, Emily, Whittemore, Alice S., Winham, Stacey J., Wolk, Alicja, Woo, Yin-Ling, Wu, Anna H., Yan, Li, Yannoukakos, Drakoulis, Zavaglia, Katia M., Zheng, Wei, Ziogas, Argyrios, Zorn, Kristin K., Kleibl, Zdenek, Easton, Douglas, Lawrenson, Kate, DeFazio, Anna, Sellers, Thomas A., Ramus, Susan J., Pearce, Celeste L., Monteiro, Alvaro N., Cunningham, Julie, Goode, Ellen L., Schildkraut, Joellen M., Berchuck, Andrew, Chenevix-Trench, Georgia, Gayther, Simon A., Antoniou, Antonis C., and Pharoah, Paul D. P.
100. Copy Number Variants Are Ovarian Cancer Risk Alleles at Known and Novel Risk Loci.
- Author
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DeVries AA, Dennis J, Tyrer JP, Peng PC, Coetzee SG, Reyes AL, Plummer JT, Davis BD, Chen SS, Dezem FS, Aben KKH, Anton-Culver H, Antonenkova NN, Beckmann MW, Beeghly-Fadiel A, Berchuck A, Bogdanova NV, Bogdanova-Markov N, Brenton JD, Butzow R, Campbell I, Chang-Claude J, Chenevix-Trench G, Cook LS, DeFazio A, Doherty JA, Dörk T, Eccles DM, Eliassen AH, Fasching PA, Fortner RT, Giles GG, Goode EL, Goodman MT, Gronwald J, Håkansson N, Hildebrandt MAT, Huff C, Huntsman DG, Jensen A, Kar S, Karlan BY, Khusnutdinova EK, Kiemeney LA, Kjaer SK, Kupryjanczyk J, Labrie M, Lambrechts D, Le ND, Lubiński J, May T, Menon U, Milne RL, Modugno F, Monteiro AN, Moysich KB, Odunsi K, Olsson H, Pearce CL, Pejovic T, Ramus SJ, Riboli E, Riggan MJ, Romieu I, Sandler DP, Schildkraut JM, Setiawan VW, Sieh W, Song H, Sutphen R, Terry KL, Thompson PJ, Titus L, Tworoger SS, Van Nieuwenhuysen E, Edwards DV, Webb PM, Wentzensen N, Whittemore AS, Wolk A, Wu AH, Ziogas A, Freedman ML, Lawrenson K, Pharoah PDP, Easton DF, Gayther SA, and Jones MR
- Subjects
- Female, Humans, Carcinoma, Ovarian Epithelial genetics, Alleles, DNA Copy Number Variations, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Genome-Wide Association Study, Ovarian Neoplasms genetics, Ovarian Neoplasms pathology
- Abstract
Background: Known risk alleles for epithelial ovarian cancer (EOC) account for approximately 40% of the heritability for EOC. Copy number variants (CNVs) have not been investigated as EOC risk alleles in a large population cohort., Methods: Single nucleotide polymorphism array data from 13 071 EOC cases and 17 306 controls of White European ancestry were used to identify CNVs associated with EOC risk using a rare admixture maximum likelihood test for gene burden and a by-probe ratio test. We performed enrichment analysis of CNVs at known EOC risk loci and functional biofeatures in ovarian cancer-related cell types., Results: We identified statistically significant risk associations with CNVs at known EOC risk genes; BRCA1 (PEOC = 1.60E-21; OREOC = 8.24), RAD51C (Phigh-grade serous ovarian cancer [HGSOC] = 5.5E-4; odds ratio [OR]HGSOC = 5.74 del), and BRCA2 (PHGSOC = 7.0E-4; ORHGSOC = 3.31 deletion). Four suggestive associations (P < .001) were identified for rare CNVs. Risk-associated CNVs were enriched (P < .05) at known EOC risk loci identified by genome-wide association study. Noncoding CNVs were enriched in active promoters and insulators in EOC-related cell types., Conclusions: CNVs in BRCA1 have been previously reported in smaller studies, but their observed frequency in this large population-based cohort, along with the CNVs observed at BRCA2 and RAD51C gene loci in EOC cases, suggests that these CNVs are potentially pathogenic and may contribute to the spectrum of disease-causing mutations in these genes. CNVs are likely to occur in a wider set of susceptibility regions, with potential implications for clinical genetic testing and disease prevention., (© The Author(s) 2022. Published by Oxford University Press.)
- Published
- 2022
- Full Text
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