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51. Autonomous vehicles effects on public transport systems.

Author

Trubia, Salvatore, Curto, Salvatore, Severino, Alessandro, Arena, Fabio, Zuccalà, Yuri, Simos, Theodore, Kalogiratou, Zacharoula, and Monovasilis, Theodore

Subjects
BUS transportation, FOSSIL fuels, QUALITY of service, ELECTRIC vehicles, AUTOMOBILES
Abstract

Nowadays cities are subjected to an urbanization increase, such phenomena has several consequences that affect different topics but especially regard urban mobility, because of this increase the number of people using cars rises consequently congestion and CO2 emissions increase. The rise of private vehicles circulating creates a decrease of average speed travel that affect the entire city context so its liveability, then when a high number of vehicles moves into infrastructure that was not designed for that capacity probability of collision will increase due to the elevated interaction compromising people safety. For this reasons public transport systems represents a key role in the liveability of a city because most of them operates in reserved areas and moreover decrease the number of private vehicles moving in cities. The progress that automotive was subjected to affected also urban mobility, first of all the innovation that mainly involved public transport regarded the use of electric vehicles instead of fossil fuels ones, that had a significant environmental impact on bus public transport systems that used fossil fuels vehicles. Anyway the most important innovation that in the last decade is involving automotive regards autonomous vehicles (AVs), these new technologies represent an important change for public transport efficiency due to the elevated performance so the relevant reduction of human mistakes, then because of the high precision of headways would provide a high quality service. Taking into account that each public transport systems has its own characteristics in relation to vehicles type and configuration, the introduction of autonomous vehicles requires specific adjustments and changes. [ABSTRACT FROM AUTHOR]

Published
2020
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52. The use of UAVs for civil engineering infrastructures.

Author

Trubia, Salvatore, Curto, Salvatore, Severino, Alessandro, Arena, Fabio, Puleo, Lucio, Simos, Theodore, Kalogiratou, Zacharoula, and Monovasilis, Theodore

Subjects
CIVIL engineering, CIVIL engineers, DETERIORATION of materials, WORLD War II, COST control, BRIDGES, AUTOMOBILE technological innovations
Abstract

Civil Infrastructures regardless sector they belong to as hydraulic (dams, pipelines), transport (bridges, roadways) or building represent a fundamental element for our lives quality and improvements then considering the continuous technological progress, existing infrastructures have to be adjusted in order to cohabit with innovations or to be complementary to new constructions. For these reasons it is important to guarantee their complete efficiency with correct maintenance operations but especially monitoring ones so to forecast imminent damages, considering that during its life cycle a generic infrastructure is subjected to dynamic and various loads, deterioration of materials and atmospheric agents that can compromise its functionality. Such aspects result fundamental considering that in many developed countries as Europe most of existing bridges were realized in world war two decades, then for example in USA 70% of roads and bridges was realized before 1930s while in Japan majority of bridges was built in 1970s. Nowadays technologies used for monitoring interventions or inspections are several but most of them are intrusive and require the need of certified human operators, these aspects create a significant safe risk and cost increase both for operators payment and equipment, then the service that an infrastructure has to provide is compromised as for example traffic interruption for bridges. In last decades to solve critical issues due to operators cost and safety or services interruption, UAVs (Unmanned Aerial Vehicles) commonly known as drones were used for monitoring operations, such systems have several advantages mostly because they are not intrusive and do not require a human operator. For these reasons especially due to cost reductions, UAVs for civil engineering infrastructure are expected to reach €40 billion market worth in next decade. [ABSTRACT FROM AUTHOR]

Published
2020
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53. The use of BIM for infrastructures.

Author

Arena, Fabio, Curto, Salvatore, Trubia, Salvatore, Puleo, Lucio, Severino, Alessandro, Simos, Theodore, Kalogiratou, Zacharoula, and Monovasilis, Theodore

Subjects
BUILDING information modeling, COST control, SOLE proprietorship, TIME management, INFORMATION sharing
Abstract

Design phases of any type of infrastructure need the intervention of several techniques and professionals figures in order to achieve an optimal efficiency during realization phases and then for the infrastructure life cycle, considering that in such contexts there is a cooperation of several figures it is important to facilitate and speed up operations regarding creation of models, calculation and files information sharing. In order to meet these needs it was implemented the so called BIM, a new method that allows software interoperability and integration among various processes, BIM's acronym stands for "Building Information Modeling" and it is defined as a "digital representation of physical and functional characteristics of an object". Thanks to such model it is possible to integrate data of different aspects (structural, architectural, management, energy) realizing a model that is characterized by all useful information as dimensions, materials or costs that will not be lost or divided during file transfer. These skills allowed BIM to spread quickly, especially for advantages linked to better costs and times management so that benefits involves also the reduction of CO2 emissions in fact to promote such objective many countries as Norway, USA, Singapore and UK have incentivized BIM use for AECO (Architecture, Engineering, Construction, Owner and Operator) industry aiming to reduce 80% of emissions in 2050. The use of BIM for infrastructure has a positive and important trend so that it is starting to be introduced also in countries legislation as a fundamental design criteria, and in future it is expected to become mandatory. [ABSTRACT FROM AUTHOR]

Published
2020
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55. The Management Of Pedestrian Emergency Through Dynamic Assignment: Some Consideration About The “Refugee Hellenism“ Square Of Kalamaria (Greece).

Author

Tesoriere, Giovanni, Canale, Antonino, Severino, Alessandro, Mrak, Iva, and Campisi, Tiziana

Subjects
ASSIGNMENT problems (Programming), EMERGENCY management, HELLENISM, PEDESTRIANS, PEDESTRIAN areas, PUBLIC safety
Abstract

Generally the safety of public areas plays a fundamental role in the liveability of a city. Different evacuation simulations are carried out over the years in order to mitigate the problems connected to a chaotic movement of pedestrians. The panicgenerated by a possible risky event, often involves variations in the trajectories assumed in the same spaces in safe conditions. This is due to the variations in speed, pedestrian density in the sub-areas and if not properly evaluated, the evacuation process could generate crowds and therefore congestion, reducing the distance from the area object of an event. The present study focuses on the evaluation of different scenarios applied to the named square of Kalamaria (Greece) which is located near the two biggest pedestrian areas of the city. The study approach, based on pedestrian micro-simulation, is focused on the dynamic assignment, implemented in order to shape the path pedestrian choice behaviour by omitting the creation of static routes and using the OD matrix as flow input instead. Different steps are established in order to enquire input data, to calibrate the tool and obtain the results. These are based on the definition of areas and sub-areas in accordance with the pedestrian social force model. Through dynamic pedestrian assignment, different parameters were compared including speeds, density pedestrian and the LOS (Level Of Service), crossing the main square which may lead to benefits or criticalities as the risk level increases. [ABSTRACT FROM AUTHOR]

Published
2019
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59. L'ORDINE DELLA CREAZIONE: Riflessioni a partire da una lettura sinottica della Summa theologiae e della Laudato si.

Author

SEVERINO, ALESSANDRO

Subjects
*HEART beat, *THEOLOGICAL anthropology, *MALE authors, *THEOLOGY, *ANTHROPOLOGY, *VOCATION
Abstract

The article aims to bring the ecological "problem" back into the broader horizon of theological reflection, in a theology of creation perspective that puts the Summa theologiae and the encyclical Laudato si' in the background. By exploring the link between true theology and true anthropology, the Author contemplates man as the "beating heart" of creation, which must bring life to the whole creation, by means of a free response to his creative vocation as "custodian". Examining the intrinsic relationship between "order of creation", "natural order" and "moral order", the article draw attention to the anthropological root of the environmental question, also highlighting how an "ecological conversion" can be reached only in the context of a "theological conversion". [ABSTRACT FROM AUTHOR]

Published
2020

64. Allogeneic transplantation in multiple myeloma

Author

Majolino, Ignazio and Severino, Alessandro

Subjects
autologous transplant, Mieloma múltiplo, surgical procedures, operative, treatment, Multiple myeloma, altas doses de quimioterapia, high dose chemotherapy, transplante autólogo, transplante alogênico, allogeneic transplant
Abstract

In this review the authors present a state of art tretment of multiple myeloma.High dose chemo-radiotherapy followed by autologous hematopoietic stem cell transplantation has been show to be superior a conventional chemotherapy and a double transplantation. The authors discuss too, the allogeneic transplantation with reduced intensity conditioning, allogeneic versus tandem autologous, results the patients long term outcome and a approach about the use of donor lymphocytes, anti thimocyte globulin and a overview of post transplant therapies. Neste relato os autores apresentam uma revisão sobre o estado atual do tratamento mieloma múltiplo. São enfatizados aspectos sobre a vantagem do transplante autólogo em seguimento à quimioterapia convencional e o duplo transplante. São discutidos o transplante alogênico e o condicionamento com intensidade reduzida, além do uso de linfócitos do doador, da globulina antitimocítica e uma visão geral do futuro da terapia da moléstia.

Published
2009

65. Post-Transplantation Cyclophosphamide (PT-CY) After Myeloablative Conditioning Regimen (MAC) In Unmanipulated Haploidentical Bone Marrow Transplantation (hBMT) Is Highly Effective As Gvhd Prophylaxis and Disease Free Survival In Pediatric and Adult Patients With High Risk Leukemia

Author

Domenica Simone, Maria, primary, Proia, Anna, additional, Severino, Alessandro, additional, Shardlow, Alison, additional, Natale, Novella, additional, Spirito, Francesca, additional, Garzia, Mariagrazia, additional, Montante, Barbara, additional, Locasciulli, Anna, additional, and Majolino, Ignazio, additional

Published
2013
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69. Performance Evaluation of a Hybrid PSO Enhanced ANFIS Model in Prediction of Traffic Flow of Vehicles on Freeways: Traffic Data Evidence from South Africa.

Author

Olayode, Isaac Oyeyemi, Severino, Alessandro, Tartibu, Lagouge Kwanda, Arena, Fabio, and Cakici, Ziya

Subjects
PARTICLE swarm optimization, TRAFFIC flow, EXPRESS highways, VEHICLES
Abstract

In the last few years, there has been a significant rise in the number of private vehicles ownership, migration of people from rural areas to urban cities, and the rise in the number of under-maintained freeways; all these have added to the perennial problem of traffic congestion. Traffic flow prediction has been recognized as the solution in alleviating and reducing the problem of traffic congestion. In this research, we developed an adaptive neuro-fuzzy inference system trained by particle swarm optimization (ANFIS-PSO) by performing an evaluative performance of the model through traffic flow modelling of vehicles on five freeways ( N 1 , N 3 , N 12 , N 14   and   N 17) using South Africa Transportation System as a case study. Six hundred and fifty (650) traffic data were collected using inductive loop detectors and video cameras from the five freeways. The traffic data used for developing these models comprises traffic volume, traffic density, speed of vehicles, time, and different types of vehicles. The traffic data were divided into 70% and 30% for the training and validation of the model. The model results show a positively correlated optimal performance between the inputs and the output with a regression value R 2   of 0.9978 and 0.9860 for the training and testing. The result of this research shows that the soft computing model ANFIS-PSO used in this research can model vehicular traffic flow on freeways. Furthermore, the evidence from this research suggests that the on-peak and off-peak hours are significant determinants of vehicular traffic flow on freeways. The modelling approach developed in this research will assist urban planners in developing practical ways to tackle traffic congestion and assist motorists and pedestrians in travel behaviour decision-making. Finally, the approach used in this study will assist transportation engineers in making constructive and safety dependent guidelines for drivers and pedestrians on freeways. [ABSTRACT FROM AUTHOR]

Published
2022
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70. V2X Communications Applied to Safety of Pedestrians and Vehicles.

Author

Arena, Fabio, Pau, Giovanni, and Severino, Alessandro

Subjects
PEDESTRIAN accidents, TRAFFIC congestion, TRAFFIC signs & signals, BUILDING sites, SYSTEMS development, VEHICLES, PEDESTRIANS
Abstract

Connected cars and vehicle-to-everything (V2X) communication scenarios are attracting more researchers. There will be numerous possibilities offered by V2X in the future. For instance, in the case of vehicles that move in a column, they could react to the braking of those in front of it through the rapid information exchanges, and most chain collisions could be avoided. V2X will be desiderated for routes optimizations, travel time reductions, and accident rate decrease in cases such as communication with infrastructures, traffic information exchanges, functioning of traffic lights, possible situations of danger, and the presence of construction sites or traffic jams. Furthermore, there could be massive conversations between smartphones and vehicles performing real-time dialogues. It is relatively reasonable to expect a connection system in which a pedestrian can report its position to all surrounding vehicles. Regarding this, it is compelling to perceive the positive effects of the driver being aware of the presence of pedestrians when vehicles are moving on the roads. This paper introduces the concepts for the development of a solution based on V2X communications aimed at vehicle and pedestrian safety. A potential system architecture for the development of a real system, concerning the safety of vehicles and pedestrians, is suggested to draft some guidelines that could be followed in new applications. [ABSTRACT FROM AUTHOR]

Published
2020
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72. Additive Formwork: Examining Design, Fabrication Space and Resolution for Bespoke Concrete Elements

Author

Naboni, Roberto, Breseghello, Luca, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Altan, Haşim, editor, Sepasgozar, Samad, editor, Olanrewaju, Abdullateef, editor, García Peñalvo, Francisco José, editor, Gaetano Severino, Alessandro, editor, Iyamu, Tiko, editor, and Lee, Ju Hyun, editor

Published
2022
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73. Reflections on New Urbanism at the COVID-19 Pandemic Background—Urban Health Research

Author

Hu, Junyu, Hu, Xinyi, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Altan, Haşim, editor, Sepasgozar, Samad, editor, Olanrewaju, Abdullateef, editor, García Peñalvo, Francisco José, editor, Gaetano Severino, Alessandro, editor, Iyamu, Tiko, editor, and Lee, Ju Hyun, editor

Published
2022
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74. Implementation and Evaluation of a MLaaS for Document Classification with Continuous Deep Learning Models

Author

Walter-Tscharf, Franz Frederik Walter Viktor, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Altan, Haşim, editor, Sepasgozar, Samad, editor, Olanrewaju, Abdullateef, editor, García Peñalvo, Francisco José, editor, Gaetano Severino, Alessandro, editor, Iyamu, Tiko, editor, and Lee, Ju Hyun, editor

Published
2022
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75. Ceiling Sound Reflectors to Optimize Acoustic Performance Using Parametric Tools

Author

Pool, Doris A. Chi, Trujillo, Jaqueline S. McNamara, Meza, Edwin González, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Altan, Haşim, editor, Sepasgozar, Samad, editor, Olanrewaju, Abdullateef, editor, García Peñalvo, Francisco José, editor, Gaetano Severino, Alessandro, editor, Iyamu, Tiko, editor, and Lee, Ju Hyun, editor

Published
2022
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76. A Chronological Exploration of Initiatives in an Automobile Cluster: A Case of Pithampur, Madhya Pradesh, India

Author

Madhavi, Pratyoosh, Choudhury, Binayak, Kumar, Ankit, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Altan, Haşim, editor, Sepasgozar, Samad, editor, Olanrewaju, Abdullateef, editor, García Peñalvo, Francisco José, editor, Gaetano Severino, Alessandro, editor, Iyamu, Tiko, editor, and Lee, Ju Hyun, editor

Published
2022
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77. Research on Policy and Management of Urban Underground Space Utilization

Author

Sun, Lijun, Leng, Jiawei, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Altan, Haşim, editor, Sepasgozar, Samad, editor, Olanrewaju, Abdullateef, editor, García Peñalvo, Francisco José, editor, Gaetano Severino, Alessandro, editor, Iyamu, Tiko, editor, and Lee, Ju Hyun, editor

Published
2022
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78. Forescast of Short-Term Energy Production in Ecuador 50 MW Huascachaca Mines Wind Farm

Author

Espinoza, Anibal, Arias-Reyes, Pablo, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Altan, Haşim, editor, Sepasgozar, Samad, editor, Olanrewaju, Abdullateef, editor, García Peñalvo, Francisco José, editor, Gaetano Severino, Alessandro, editor, Iyamu, Tiko, editor, and Lee, Ju Hyun, editor

Published
2022
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79. Energy Efficiency Analysis in the Residential Sector of the Urban Area of Canton Saraguro, Ecuador

Author

Morocho, Cesar, Campoverde, Gerardo, González, Javier, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Altan, Haşim, editor, Sepasgozar, Samad, editor, Olanrewaju, Abdullateef, editor, García Peñalvo, Francisco José, editor, Gaetano Severino, Alessandro, editor, Iyamu, Tiko, editor, and Lee, Ju Hyun, editor

Published
2022
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80. Building Information Modeling on Construction Safety: A Literature Review

Author

dela Cruz, Orlean G., Ongpeng, Jason Maximino C., Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Altan, Haşim, editor, Sepasgozar, Samad, editor, Olanrewaju, Abdullateef, editor, García Peñalvo, Francisco José, editor, Gaetano Severino, Alessandro, editor, Iyamu, Tiko, editor, and Lee, Ju Hyun, editor

Published
2022
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81. The Application of Digital Technologies into Utilizing Urban Voids

Author

Elgizawy, Ebtesam Mohamed Ahmed, Elewa, Ali Khaled Ahmed, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Altan, Haşim, editor, Sepasgozar, Samad, editor, Olanrewaju, Abdullateef, editor, García Peñalvo, Francisco José, editor, Gaetano Severino, Alessandro, editor, Iyamu, Tiko, editor, and Lee, Ju Hyun, editor

Published
2022
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82. Sustainable Architecture from Proper Recycling: Renewable Energy Integration and Housing Automation

Author

Morales, Diego X., Berzosa, Julio, Moscoso, Santiago, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Altan, Haşim, editor, Sepasgozar, Samad, editor, Olanrewaju, Abdullateef, editor, García Peñalvo, Francisco José, editor, Gaetano Severino, Alessandro, editor, Iyamu, Tiko, editor, and Lee, Ju Hyun, editor

Published
2022
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83. Digital Methods and Tools for Mapping Public–Private Partnership Opportunities and Evaluating Proposals in the Regeneration Plans of Building Assets

Author

Cacciaguerra, Elisa, Garofolo, Ilaria, Strazza, Nicola, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Altan, Haşim, editor, Sepasgozar, Samad, editor, Olanrewaju, Abdullateef, editor, García Peñalvo, Francisco José, editor, Gaetano Severino, Alessandro, editor, Iyamu, Tiko, editor, and Lee, Ju Hyun, editor

Published
2022
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84. A Digital Twin-Based System for Smart Management of Office Spaces

Author

Marocco, Marco, Garofolo, Ilaria, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Altan, Haşim, editor, Sepasgozar, Samad, editor, Olanrewaju, Abdullateef, editor, García Peñalvo, Francisco José, editor, Gaetano Severino, Alessandro, editor, Iyamu, Tiko, editor, and Lee, Ju Hyun, editor

Published
2022
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85. Assessing the Environmental Aspects of Road Network Resiliency

Author

Mehrabani, Behzad Bamdad, Sgambi, Luca, Madani, Negarsadat, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Altan, Haşim, editor, Sepasgozar, Samad, editor, Olanrewaju, Abdullateef, editor, García Peñalvo, Francisco José, editor, Gaetano Severino, Alessandro, editor, Iyamu, Tiko, editor, and Lee, Ju Hyun, editor

Published
2022
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86. Design a Computer Program for Sustainable Materials to Apply in Egyptian Housing

Author

Tawfeeq, Bishoy Magdy, Elborombaly, Hossam Eldin Hassan Othman, Altawansy, Ali Kamal Ali, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Altan, Haşim, editor, Sepasgozar, Samad, editor, Olanrewaju, Abdullateef, editor, García Peñalvo, Francisco José, editor, Gaetano Severino, Alessandro, editor, Iyamu, Tiko, editor, and Lee, Ju Hyun, editor

Published
2022
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87. Evaluating the Daylighting and Energy Performance of Container Housing Systems in Coastal Regions: An Iterative Modeling Approach

Author

Haque, Md. Obidul, Rahman, Nabeela Nushaira, Tabassum, Nusrat, Aman, Jayedi, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Altan, Haşim, editor, Sepasgozar, Samad, editor, Olanrewaju, Abdullateef, editor, García Peñalvo, Francisco José, editor, Gaetano Severino, Alessandro, editor, Iyamu, Tiko, editor, and Lee, Ju Hyun, editor

Published
2022
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88. Interaction of Prehistoric Heritage with Today’s Landscape: The Case Study of Arslantepe Mound (Malatya/TURKEY)

Author

Tuna, Aysun, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Altan, Haşim, editor, Sepasgozar, Samad, editor, Olanrewaju, Abdullateef, editor, García Peñalvo, Francisco José, editor, Gaetano Severino, Alessandro, editor, Iyamu, Tiko, editor, and Lee, Ju Hyun, editor

Published
2022
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89. Environmental Product Declarations for Building Materials: Advantages, Limits, Developments

Author

Scalisi, Francesca, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Altan, Haşim, editor, Sepasgozar, Samad, editor, Olanrewaju, Abdullateef, editor, García Peñalvo, Francisco José, editor, Gaetano Severino, Alessandro, editor, Iyamu, Tiko, editor, and Lee, Ju Hyun, editor

Published
2022
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90. Public–Private Partnerships in Romanian New Urban Developments—A Potential Valuable Instrument in the Privatization Era

Author

Voinea, Luiza O., Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Altan, Haşim, editor, Sepasgozar, Samad, editor, Olanrewaju, Abdullateef, editor, García Peñalvo, Francisco José, editor, Gaetano Severino, Alessandro, editor, Iyamu, Tiko, editor, and Lee, Ju Hyun, editor

Published
2022
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91. Application of Virtual Reality to Enhance the Interpretation Dong Ho Folk Paintings in Museums of Fine Arts in Ho Chi Minh City

Author

Pham, Ngoc Quynh Giao, Nguyen, Minh Hieu, Le, Trieu Hoang Anh, Adzovie, Daniel Edem, Stanicky, Petr, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Altan, Haşim, editor, Sepasgozar, Samad, editor, Olanrewaju, Abdullateef, editor, García Peñalvo, Francisco José, editor, Gaetano Severino, Alessandro, editor, Iyamu, Tiko, editor, and Lee, Ju Hyun, editor

Published
2022
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92. Hygromorphs: Exploring Morphologies of Architectural Adaptive Systems Using Hygroscopic Properties of Wood

Author

Ibrahim, Aly, Abdelmohsen, Sherif, Zayan, Akram, Omar, Walid, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Altan, Haşim, editor, Sepasgozar, Samad, editor, Olanrewaju, Abdullateef, editor, García Peñalvo, Francisco José, editor, Gaetano Severino, Alessandro, editor, Iyamu, Tiko, editor, and Lee, Ju Hyun, editor

Published
2022
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93. Analyzing Public Transport System in Twin Cities of Rawalpindi/Islamabad

Author

Sheikh, Abdul Basit, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Altan, Haşim, editor, Sepasgozar, Samad, editor, Olanrewaju, Abdullateef, editor, García Peñalvo, Francisco José, editor, Gaetano Severino, Alessandro, editor, Iyamu, Tiko, editor, and Lee, Ju Hyun, editor

Published
2022
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94. Integrated Design Concept for Identifiable Commercial Heritage Tourism in Tunjungan District of Surabaya City

Author

Kusliansjah, Yohanes Karyadi, Patriajaya, Anneke Clauvinia, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Altan, Haşim, editor, Sepasgozar, Samad, editor, Olanrewaju, Abdullateef, editor, García Peñalvo, Francisco José, editor, Gaetano Severino, Alessandro, editor, Iyamu, Tiko, editor, and Lee, Ju Hyun, editor

Published
2022
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95. Dysplastic bone marrow changes during maintenance therapy for acute leukemia

Author

Alison Shardlow, Samuele Naviglio, Anna Locasciulli, Matteo Chinello, Alessandro Severino, Alessandro Ventura, Chinello, Matteo, Naviglio, Samuele, Shardlow, Alison, Severino, Alessandro, Ventura, Alessandro, and Locasciulli, Anna

Subjects
medicine.medical_specialty, Gastroenterology, Folinic acid, Immunophenotyping, Maintenance therapy, hemic and lymphatic diseases, Internal medicine, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Child, Bone Marrow Diseases, Acute leukemia, Bone Marrow Smear, business.industry, dysplastic bone marrow, Mercaptopurine, leukemia, Disease Management, Hematology, medicine.disease, Prognosis, Pancytopenia, medicine.anatomical_structure, Hypocellularity, Methotrexate, Oncology, Pediatrics, Perinatology and Child Health, Female, Bone marrow, business, medicine.drug, Follow-Up Studies
Abstract

We describe the case of an 8-year-old girl with common precursor B-cell acute lymphoblastic leukemia who presented with severe pancytopenia during maintenance therapy with methotrexate and 6-mercaptopurine. The bone marrow smear showed moderate hypocellularity and trilinear dysplastic changes consistent with a diagnosis of drug toxicity, with no evidence of lymphoblasts. Flow cytometric immunophenotyping was negative for leukemic cells. Blood cell counts normalized after treatment with folinic acid. Maintenance therapy was gradually restarted and she remained well at follow-up visits. Myelotoxicity from methotrexate and 6-mercaptopurine may represent an unpredictable incident during an otherwise uneventful maintenance therapy, and may occur independently of other organ toxicities.

Published
2014

96. Primary cutaneous B cell lymphoma, leg type presenting as a diabetic ulcer: A challenging diagnosis.

Author

Russo D, Cretella P, Varricchio S, Mosella F, D'Andrea F, Severino A, and Mascolo M

Subjects
Adult, Aged, Humans, Leg pathology, Male, Ulcer, Carcinoma, Squamous Cell, Diabetes Complications, Diabetes Mellitus, Lymphoma, B-Cell pathology, Skin Neoplasms complications, Skin Neoplasms diagnosis, Skin Neoplasms pathology
Abstract

Introduction: A crescent number of reports describe malignant dermal malignancies presenting as diabetic ulcers, such as melanoma, Kaposi's sarcoma, squamous cell carcinoma and cutaneous lymphoma., Methods: The authors reported the clinical and histopathological features of this challenging case of a PCBCL, leg type presenting as a foot ulcer to exemplify the diagnostic difficulties, mainly when, at the onset, this tumour exhibits uncharacteristic features., Case Report: A 43 years-old male with a 10-year history of compensated type I diabetes developed an ulcerated 3 cm of diameter tumour on the lateral region of the right foot. This lesion had previously been biopsied and treated as a diabetic neuropathic ulcer elsewhere. Due to the appearance of intralesional necrosis associated with stable inflammation and diabetes laboratory parameters, the clinicians made a provisional clinical diagnosis of pyoderma gangrenosum and performed further two incisional biopsies. Histology showed a clear-cut PCBCL, leg type., Conclusions: Diabetic skin lesions, especially in older patients with persistent non-healing characteristics of pain and tenderness, must be carefully managed through the close correlation of clinical, imaging, and histological features. A correct diagnosis allows avoiding inadequate treatment, which would lead to severe consequences for these patients., (Copyright © 2022 Elsevier GmbH. All rights reserved.)

Published
2022
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97. Prognostic value of Bcl2 and Bcl6 in primary cutaneous large B-cell lymphoma: A systematic review and meta-analysis.

Author

Russo D, Travaglino A, Varricchio S, Pace M, Cretella P, Baldo A, Severino A, Picardi M, and Mascolo M

Subjects
Humans, Prognosis, Proportional Hazards Models, Proto-Oncogene Proteins c-bcl-2 analysis, Proto-Oncogene Proteins c-bcl-2 genetics, Proto-Oncogene Proteins c-bcl-6 genetics, Survival Analysis, Lymphoma, Large B-Cell, Diffuse pathology
Abstract

Aims: To assess the prognostic value of Bcl2 and Bcl6 in primary cutaneous diffuse large B-cell lymphoma (pcDLBCL), through a systematic review and meta-analysis., Methods: Electronic databases were searched from their inception to April 2021 for studies reporting Bcl2 and Bcl6 expression and survival outcomes in pcDLBCL series. Kaplan-Meier and Cox regression survival analyses with hazard ratio calculation were performed for overall survival (OS), with a significant p-value< 0.05., Results: Eight studies with 148 patients were included. OS was significantly decreased in Bcl2-pos itive pcDLBCLs (5-year OS= 52.9 ± 5.2%) compared to Bcl2 negative pcDLBCLs (5-year OS= 86.6 ± 7.2%), with a HR of 4.615 (95% CI, 1.827-11.657; p = 0.001); no significant difference in OS was found between Bcl6-positive pcDLBCLs (5-year OS= 61.3 ± 6.5%) and Bcl6-negative pcDLBCLs (5-year OS= 56.8 ± 7.2%), with a HR of 0.789 (95% CI, 0.462-1.350; p = 0.388)., Conclusions: In pcDLBCL, Bcl2 expression is a strong unfavourable prognostic marker; Bcl6 does not seem to be associated with survival instead. Further studies are necessary in this field., (Copyright © 2022 Elsevier GmbH. All rights reserved.)

Published
2022
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98. Involvement of Helicobacter Pylori in Ocular Adnexa Lymphoma.

Author

Travaglino A, Pace M, Varricchio S, Russo D, Pugliese N, Severino A, Picardi M, Pane F, Insabato L, Staibano S, and Mascolo M

Subjects
Eye Neoplasms epidemiology, Helicobacter Infections virology, Humans, Lymphoma epidemiology, Prognosis, Eye Neoplasms virology, Helicobacter Infections complications, Helicobacter pylori isolation & purification, Lymphoma virology
Abstract

Helicobacter pylori has been proposed as a possible etiologic factor of ocular adnexa lymphoma (OAL), although with conflicting results. To assess the involvement of H. pylori in OAL, as (1) H. pylori DNA positivity on OAL specimens, and (2) prevalence of H. pylori gastric infection in patients with OAL. A systematic review of studies assessing H. pylori in patients with OAL was conducted by searching electronic databases from their inception to May 2019. Pooled positivity for H. pylori in OAL specimens detected by polymerase chain reaction, and pooled prevalence of H. pylori gastric infection, were calculated with 95% confidence interval (CI). Eleven studies with 308 patients were included. Pooled positivity for H. pylori was 16.8% in all OALs and 22.7% in MALT OAL, with high heterogeneity among studies. Pooled prevalence of H. pylori gastric infection in patients with OAL was 34.7%, with low statistical heterogeneity. In conclusion, H. pylori seems to be involved in a subset of OAL, but the heterogeneity found needs to be investigated in further studies. The prevalence of H. pylori gastric infection in patients with OAL does not seem to differ from that of the general population.

Published
2020
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99. Clinical features associated with high pathological grade in primary thyroid lymphoma.

Author

Travaglino A, Pace M, Varricchio S, Insabato L, Picardi M, Severino A, Pane F, Staibano S, and Mascolo M

Subjects
Adult, Aged, Female, Humans, Male, Middle Aged, Neoplasm Grading, Lymphoma pathology, Thyroid Neoplasms pathology
Abstract

This study aimed to identify clinical features associated with high pathological grade (HG) in primary thyroid lymphoma (PTL), through a systematic review and meta-analysis. Electronic databases were searched for studies assessing PTL. Extracted data were age, sex, lymph node involvement, symptoms, lymphocytic thyroiditis, serum tumor markers; the association with HG was assessed by using odds ratio (OR), with a significant p-value<0.05. Twenty-four studies with 1916 PTLs were included. HG was significantly associated with age≤55 (OR = 0.54; p < 0.0001); female sex (OR = 1.31; p = 0.02), lymph node involvement (OR = 2.23; p < 0.00001), compressive symptoms (OR = 2.61; p < 0.0001), absence of lymphocytic thyroiditis (OR = 0.45; p = 0.0002), and increased LDH levels (OR = 4.90; p < 0.00001), but not with age>60 (OR = 0.74; p = 0.24), age>70 (OR = 1.16; p = 0.66), and B symptoms (OR = 1.30; p = 0.54). In conclusion, Age≤55, female sex, lymph node involvement, compressive symptoms and absence of lymphocytic thyroiditis may be predictive factors for HG in PTL. On the other hand, B symptoms does not seem to be associated with pathological grade., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier GmbH. All rights reserved.)

Published
2020
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