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578 results on '"Shaw, Andrey S"'

52. KSR2 Is an Essential Regulator of AMP Kinase, Energy Expenditure, and Insulin Sensitivity

Author

Costanzo-Garvey, Diane L., Pfluger, Paul T., Dougherty, Michele K., Stock, Jeffery L., Boehm, Matthew, Chaika, Oleg, Fernandez, Mario R., Fisher, Kurt, Kortum, Robert L., Hong, Eun-Gyoung, Jun, John Y., Ko, Hwi Jin, Schreiner, Aimee, Volle, Deanna J., Treece, Tina, Swift, Amy L., Winer, Mike, Chen, Denise, Wu, Min, Leon, Lisa R., Shaw, Andrey S., McNeish, John, Kim, Jason K., Morrison, Deborah K., Tschöp, Matthias H., and Lewis, Robert E.

Published
2009
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56. Novel markers of normal and neoplastic human plasmacytoid dendritic cells

Author

Marafioti, Teresa, Paterson, Jennifer C., Ballabio, Erica, Reichard, Kaaren K., Tedoldi, Sara, Hollowood, Kevin, Dictor, Michael, Hansmann, Martin-Leo, Pileri, Stefano A., Dyer, Martin J., Sozzani, Silvano, Dikic, Ivan, Shaw, Andrey S., Petrella, Tony, Stein, Harald, Isaacson, Peter G., Facchetti, Fabio, and Mason, David Y.

Published
2008
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57. Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomeruosclerosis

Author

Akilesh, Shreeram, Suleiman, Hani, Yu, Haiyang, Stander, M. Christine, Lavin, Peter, Gbadegesin, Rasheed, Antignac, Corinne, Pollak, Martin, Kopp, Jeffrey B., Winn, Michelle P., and Shaw, Andrey S.

Subjects
Gene mutations -- Health aspects -- Research, Epithelial cells -- Physiological aspects -- Research, Kidney diseases -- Genetic aspects -- Research -- Risk factors, Health care industry
Abstract

The specialized epithelial cell of the kidney, the podocyte, has a complex actinbased cytoskeleton. Dynamic regulation of this cytoskeleton is required for efficient barrier function of the kidney. Podocytes are a useful cell type to study the control of the actin cytoskeleton in vivo, because disruption of components of the cytoskeleton results in podocyte damage, cell loss, and a prototypic injury response called focal segmental glomerulosclerosis (FSGS). Searching for actin regulatory proteins that are expressed in podocytes, we identified a RhoA-activated Rac1 GTPase-activating protein (Rac1-GAP), Arhgap24, that was upregulated in podocytes as they differentiated, both in vitro and in vivo. Increased levels of active Rac1 and Cdc42 were measured in Arhgap24 knockdown experiments, which influenced podocyte cell shape and membrane dynamics. Consistent with a role for Arhgap24 in normal podocyte functioning in vivo, sequencing of the ARHGAP24 gene in patients with FSGS identified a mutation that impaired its Rac1-GAP activity and was associated with disease in a family with FSGS. Thus, Arhgap24 contributes to the careful balancing of RhoA and Rac1 signaling in podocytes, the disruption of which may lead to kidney disease., Introduction The kidneys filter plasma and reabsorb solutes and nutrients to maintain the appropriate extracellular environment. The proximal component of the nephron, the glomerulus, is the primary filtration barrier that [...]

Published
2011
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58. CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival

Author

Yaddanapudi, Suma, Altintas, Mehmet M., Kistler, Andreas D., Fernandez, Isabel, Moller, Clemens C., Wei, Changli, Peev, Vasil, Flesche, Jan B., Forst, Anna-Lena, Li, Jing, Patrakka, Jaakko, Xiao, Zhijie, Grahammer, Florian, Schiffer, Mario, Lohmuller, Tobias, Reinheckel, Thomas, Gu, Changkyu, Huber, Tobias B., Ju, Wenjun, Bitzer, Markus, Rastaldi, Maria P., Ruiz, Phillip, Tryggvason, Karl, Shaw, Andrey S., Faul, Christian, Sever, Sanja, and Reiser, Jochen

Subjects
Transforming growth factors -- Physiological aspects -- Research, Epithelial cells -- Physiological aspects -- Research, Kidney diseases -- Development and progression -- Research, Health care industry
Abstract

Kidney podocytes are highly differentiated epithelial cells that form interdigitating foot processes with bridging slit diaphragms (SDs) that regulate renal ultrafiltration. Podocyte injury results in proteinuric kidney disease, and genetic deletion of SD-associated CD2-associated protein (CD2AP) leads to progressive renal failure in mice and humans. Here, we have shown that CD2AP regulates the TGF-β1-dependent translocation of dendrin from the SD to the nucleus. Nuclear dendrin acted as a transcription factor to promote expression of cytosolic cathepsin L (CatL). CatL proteolyzed the regulatory GTPase dynamin and the actinassociated adapter synaptopodin, leading to a reorganization of the podocyte microfilament system and consequent proteinuria. CD2AP itself was proteolyzed by CatL, promoting sustained expression of the protease during podocyte injury, and in turn increasing the apoptotic susceptibility of podocytes to TGF-β1. Our study identifies CD2AP as the gatekeeper of the podocyte TGF-β response through its regulation of CatL expression and defines a molecular mechanism underlying proteinuric kidney disease., Introduction Several hundred million people worldwide-about 1 in 15 adults-have some form of kidney damage, and every year, millions die prematurely of cardiovascular or renal complications linked to chronic kidney [...]

Published
2011
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59. Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

Author

Hartleben, Bjorn, Godel, Markus, Meyer-Schwesinger, Catherine, Liu, Shuya, Ulrich, Theresa, Kobler, Sven, Wiech, Thorsten, Grahammer, Florian, Arnold, Sebastian J., Lindenmeyer, Maja T., Cohen, Clemens D., Pavenstadt, Hermann, Kerjaschki, Dontscho, Mizushima, Noboru, Shaw, Andrey S., Walz, Gerd, and Huber, Tobias B.

Subjects
Homeostasis -- Research -- Methods, Autophagy (Cytology) -- Research -- Methods, Epithelial cells -- Properties -- Methods -- Research, Glomerular filtration rate -- Methods -- Research, Disease susceptibility -- Evaluation -- Research, Health care industry
Abstract

Injury and loss of podocytes are leading factors of glomerular disease and renal failure. The postmitotic podocyte is the primary glomerular target for toxic, immune, metabolic, and oxidant stress, but little is known about how this cell type copes with stress. Recently, autophagy has been identified as a major pathway that delivers damaged proteins and organelles to lysosomes in order to maintain cellular homeostasis. Here we report that podocytes exhibit an unusually high level of constitutive autophagy. Podocyte-specific deletion of autophagy-related 5 (Atg5) led to a glomerulopathy in aging mice that was accompanied by an accumulation of oxidized and ubiquitinated proteins, ER stress, and proteinuria. These changes resulted ultimately in podocyte loss and late-onset glomerulosclerosis. Analysis of pathophysiological conditions indicated that autophagy was substantially increased in glomeruli from mice with induced proteinuria and in glomeruli from patients with acquired proteinuric diseases. Further, mice lacking Atg5 in podocytes exhibited strongly increased susceptibility to models of glomerular disease. These findings highlight the importance of induced autophagy as a key homeostatic mechanism to maintain podocyte integrity. We postulate that constitutive and induced autophagy is a major protective mechanism against podocyte aging and glomerular injury, representing a putative target to ameliorate human glomerular disease and aging-related loss of renal function., Introduction The kidney filtration barrier is a unique structure characterized by a complex 3-dimensional framework of podocytes and endothelial cells. Podocytes form fine interdigitating foot processes, which envelope the glomerular [...]

Published
2010
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65. Proteinuria precedes podocyte abnormalities in Lamb[2.sup.-/-] mice, implicating the glomerular basement membrane as an albumin barrier

Author

Jarad, George, Cunningham, Jeanette, Shaw, Andrey S., and Miner, Jeffrey H.

Subjects
Laminin -- Research, Proteinuria -- Research, Mice -- Physiological aspects, Mice -- Research
Abstract

Primary defects in either podocytes or the glomerular basement membrane (GBM) cause proteinuria, a fact that complicates defining the barrier to albumin. Laminin [beta]2 (LAMB2) is a GBM component required [...]

Published
2006

66. Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin

Author

Huber, Tobias B., Kwoh, Christopher, Wu, Hui, Asanuma, Katsuhiko, Godel, Markus, Hartleben, Bjorn, Blumer, Ken J., Miner, Jeffrey H., Mundel, Peter, and Shaw, Andrey S.

Subjects
Kidney diseases -- Research, Kidney diseases -- Causes of, Kidney diseases -- Genetic aspects, Genetic research, Medical research, Medicine, Experimental
Abstract

Focal segmental glomerulosclerosis (FSGS) is the most common primary glomerular diagnosis resulting in end-stage renal disease. Defects in several podocyte proteins have been implicated in the etiology of FSGS, including [...]

Published
2006

67. Glomerular expression of transforming growth factor-[beta] (TGF-[beta]) isoforms in mice lacking CD2-associated protein

Author

Woroniecki, Robert P., Schiffer, Mario, Shaw, Andrey S., Kaskel, Frederick J., and Bottinger, Erwin P.

Subjects
Glomerulonephritis -- Genetic aspects, Glomerulonephritis -- Research, Rodents as laboratory animals -- Research
Abstract

Abstract Mice lacking CD2-associated protein (CD2AP-/-) develop glomerular lesions resembling human focal segmental glomerulosclerosis (FSGS) between 3-4 weeks of age and die approximately 2 weeks later from massive proteinuria and [...]

Published
2006

68. Association of CD2AP with dynamic actin on vesicles in podocytes

Author

Welsch, Thilo, Endlich, Nicole, Gokce, Gokmen, Doroshenko, Elena, Simpson, Jeremy C., Kriz, Wilhelm, Shaw, Andrey S., and Endlich, Karlhans

Subjects
Epithelial cells -- Chemical properties, Actin -- Chemical properties, Biological sciences
Abstract

The docking protein CD2AP (CD2-associated protein) serves a nonredundant function in podocytes as CD2AP knockout mice die of renal failure at the age of 6-7 wk. Furthermore, haploinsufficiency due to mutation of the CD2AP gene is associated with focal segmental glomerulosclerosis in humans. Although CD2AP has been shown to interact with proteins regulating actin polymerization, with proteins of the slit diaphragm, and with the endocytic machinery, its critical function in podocytes remains unclear. In conditionally immortalized mouse podocytes, we demonstrate that CD2AP colocalizes with cortactin and F-actin in spots of [is less than or equal to] 0.5-[micro]m diameter. Confocal time-lapse microscopy in living podocytes expressing GFP-CD2AP or GFP-actin revealed that spots are motile, possess a limited lifetime, and are frequently associated with vesicles. A significant portion of spot-associated vesicles belongs to a later endosomal-sorting compartment, characterized by delayed uptake of fluorescent dextran (10 kDa) and by colocalization with Rab4, but not Rab5 and AP-2. Rapid accumulation of microinjected G-actin in spots and abrogation of spot motility by jasplakinolide demonstrate that spot movements depend on actin polymerization. Furthermore, a high turnover (half-time < 10 s) of CD2AP in spots was demonstrated by FRAP (fluorescence recovery after photobleaching). Our results demonstrate that CD2AP is associated with dynamic actin in a specific late endosomal compartment in podocytes, suggesting that CD2AP might be crucially involved in endosomal sorting and/or trafficking via regulation of actin assembly on vesicles. glomerular epithelial cells; CMS; green fluorescent protein

Published
2005

69. The Alzheimer risk factor CD2AP causes dysfunction of the brain vascular network

Author

Vandal, Milène, primary, Institoris, Adam, additional, Korin, Ben, additional, Gunn, Colin, additional, Lee, Suzie, additional, Lee, Jiyeon, additional, Bourassa, Philippe, additional, Mishra, Ramesh C., additional, Peringod, Govind, additional, Jiang, Yulan, additional, Hirai, Sotaro, additional, Belzil, Camille, additional, Reveret, Louise, additional, Tremblay, Cyntia, additional, Hashem, Mada, additional, Elias, Esteban, additional, Meilandt, Bill, additional, Foreman, Oded, additional, Rouse-Girma, Meron, additional, Muruve, Daniel, additional, Nicola, Wilten, additional, Körbelin, Jakob, additional, Dunn, Jeff F., additional, Braun, Andrew P., additional, Bennett, David A., additional, Gordon, Grant R.J., additional, Calon, Frédéric, additional, Shaw, Andrey S., additional, and Nguyen, Minh Dang, additional

Published
2020
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77. Contributors

Author

Abrams, John M., primary, Adelman, John P., additional, Alcorn, Joseph L., additional, Alessi, Dario R., additional, Alexov, Emil, additional, Alford, Simon, additional, Alitalo, Kari, additional, Allison, James P., additional, Almo, Steven C., additional, Alory, Christelle, additional, Al-Shamkhani, Aymen, additional, Amundson, Sally A., additional, Anderson, Carl W., additional, Andersen, Jannik N., additional, Angel, Peter, additional, Appella, Ettore, additional, Arendshorst, William J., additional, Arkinstall, Steve, additional, Audhya, Anjon, additional, Avruch, Joseph, additional, Bader, Gary D., additional, Bagala, Cinzia, additional, Balch, William E., additional, Balsinde, Jesus, additional, Banerjee, Utpal, additional, Barford, David, additional, Bar-Sagi, Dafna, additional, Bartlett, Perry F., additional, Bastiaens, Philippe I.H., additional, Battelli, Chiara, additional, Baudhuin, Linnea M., additional, Beavil, Andrew J., additional, Beavil, Rebecca L., additional, Beavo, Joseph A., additional, Bello-Reuss, Elsa, additional, Bellum, Stephen, additional, Belmonte, Juan Carlos Izpisúa, additional, Bennett, Craig B., additional, Benovic, Jeffrey L., additional, Berridge, Michael J., additional, Beuning, Penny J., additional, Bhandari, Rashna, additional, Bhattacharya, Ananya, additional, Biel, Martin, additional, Bielinski, Vincent A., additional, Bilak, Hana, additional, Birnbaumer, Lutz, additional, Birrell, Geoff, additional, Bishop, Gail A., additional, Blackmer, Trillium, additional, Blackshear, Perry J., additional, Blattner, Christine, additional, Blaustein, Mordecai P., additional, Bokoch, Gary M., additional, Bonewald, Lynda F., additional, Bonomi, Marco, additional, Booden, Michelle A., additional, Boone, Charles, additional, Bootman, Martin D., additional, Bos, Johannes L., additional, Bradbury, Jane M., additional, Bradshaw, Ralph A., additional, Bresnick, Anne R., additional, Brevnova, Lena, additional, Brinkworth, Ross I., additional, Brown, Michael S., additional, Brown, Steven A., additional, Brunet, Anne, additional, Bucki, Robert, additional, Burgoyne, Robert D., additional, Buss, Janice E., additional, Butow, Ronald A., additional, Capdevila, Javier, additional, Carafoli, Ernesto, additional, Carlson, Cathrine R., additional, Carpenter, Graham, additional, Carrillo, Juan J., additional, Casey, Patrick J., additional, Catterall, William A., additional, Cerione, Richard A., additional, Cesareni, Gianni, additional, Chan, Andrew C., additional, Chang, Geoffrey, additional, Chao, Moses V., additional, Charbonneau, Harry, additional, Chen, Philip, additional, Cheng, Alan, additional, Chiu, Chris, additional, Chow, Dar-chone, additional, Chrisman, Ted D., additional, Christensen, Anne Elisabeth, additional, Chung, Jee Y., additional, Churchill, Grant C., additional, Ciechanover, Aaron, additional, Cingolani, Gino, additional, Claeysen, Sylvie, additional, Closset, Jean, additional, Cockcroft, Shamshad, additional, Cohen, Patricia T.W., additional, Cohen, Philip, additional, Colbran, Roger J., additional, Comstock, Clay E.S., additional, Conti, Marco, additional, Corbin, Jackie D., additional, Corda, Daniela, additional, Costagliola, Sabine, additional, Cote, Rick H., additional, Coughlin, Shaun R., additional, Cowart, L. Ashley, additional, Cox, Adrienne D., additional, Cragg, Mark S., additional, Crespo, José L., additional, Crosio, Claudia, additional, Daly, Christopher, additional, Damak, Sami, additional, Dasso, Mary, additional, David, Michael, additional, Davis, Anthony J., additional, Davis, Roger J., additional, Day, Richard N., additional, Degerman, Eva, additional, DeLano, Warren L., additional, Dell'Acqua, Mark L., additional, Délot, Emmanuèle, additional, Demple, Bruce, additional, Dennis, Edward A., additional, Denu, John M., additional, DePaoli-Roach, Anna A., additional, Der, Channing J., additional, de Rooij, Johan, additional, de Sauvage, Frederic, additional, Devreotes, Peter N., additional, Dewaste, Valérie, additional, Dickson, Robert B., additional, Diebold, Becky A., additional, Fiori, Pier Paolo Di, additional, Girolamo, Maria Di, additional, Diplexcito, Julie, additional, Dixon, Jack E., additional, Doms, Robert W., additional, Donoghue, Daniel J., additional, Doolittle, Russell F., additional, Døskeland, Stein Ove, additional, Dostmann, Wolfgang R.G., additional, Dreyer, Matthias K., additional, Du, Guo Guang, additional, Du, Keyong, additional, Duchen, Michael R., additional, Dunphy, William G., additional, Durgan, Joanne, additional, Dustin, Michael L., additional, Edwards, Peter A., additional, Egen, Jackson G., additional, Eiden, Lee E., additional, Elion, Elaine A., additional, Emr, Scott, additional, Engelhardt, Othmar G., additional, Erneux, Christophe, additional, Espenshade, Peter J., additional, Esplin, Edward D., additional, Evers, B. Mark, additional, Eyles, Joanne L., additional, Fame, Sheelagh, additional, Farquhar, Marilyn, additional, Feil, Robert, additional, Feng, Gui-Jie, additional, Fields, Stanley, additional, Fiordalisi, James J., additional, Firtel, Richard A., additional, Fitzgerald, Garret A., additional, Flint, Andrew, additional, Foiani, Marco, additional, Forman, Barry Marc, additional, Fornace, Albert J., additional, Francis, Sharron H., additional, Fritz, Günter, additional, Fruman, David A., additional, Galione, Antony, additional, Gandhi, Chris S., additional, Garbers, David L., additional, Garcia, K. Christopher, additional, Geiger, Benjamin, additional, Gerace, Larry, additional, Gerstner, Andrea, additional, Giaccia, Amato J., additional, Giannattasio, Michele, additional, Giguère, Vincent, additional, Glass, Christopher K., additional, Glennie, Martin J., additional, Glick, Jennifer L., additional, Goldstein, Joseph L., additional, Gopal, Venkatesh, additional, Gorospe, Myriam, additional, Govaerts, Cedric, additional, Graves, Paul R., additional, Gray, Patrick W., additional, Graziani, Irene, additional, Green, Douglas R., additional, Greenberg, Michael E., additional, Greenwald, Iva, additional, Gu, Haihua, additional, Gueven, Nuri, additional, Gutkind, J. Silvio, additional, Haeggström, Jesper Z., additional, Hall, Alan, additional, Hall, Michael N., additional, Haller, Otto, additional, Hamm, Heidi E., additional, Hannun, Yusef A., additional, Hansen, Carl A., additional, Harden, T. Kendall, additional, Hardie, D. Grahame, additional, Hasegawa, Kiminori, additional, Hawkins, Phillip T., additional, Haystead, Timothy A.J., additional, He, Xiao-lin, additional, Heizmann, Claus W., additional, Heldin, Carl-Henrik, additional, Hermiston, Michelle L., additional, Herrlich, Peter, additional, Hewat, Elizabeth A., additional, Hille, Bertil, additional, Hilton, Douglas J., additional, Hinchliffe, K.A., additional, Ho, Steffan N., additional, Ho, Su-Chin, additional, Hochstrasser, Mark, additional, Hofmann, Franz, additional, Hogue, Christopher W., additional, Hol, Wim G.J., additional, Holash, Jocelyn, additional, Holmgren, Robert A., additional, Honig, Barry, additional, Hostager, Bruce S., additional, Hubbard, Stevan R., additional, Huber, Michael, additional, Hunter, Tony, additional, Huttenlocher, Anna, additional, Hymowitz, Sarah G., additional, Ihle, James N., additional, Imler, Jean-Luc, additional, Irvine, R.F., additional, Isacoff, Ehud Y., additional, Iturrioz, Xavier, additional, Iversen, Lars F., additional, Iyengar, Ravi, additional, Jackson, Stephen P., additional, Jan, Lily Yeh, additional, Janiak-Spens, Fabiola, additional, Janmey, Paul A., additional, Jansen, Peter Gildsig, additional, Jarriault, Sophie, additional, Javitch, Jonathan A., additional, Jensen, Elwood V., additional, Jepsen, Kristen, additional, Jones, E. Yvonne, additional, Jones, Katherine A., additional, Jordan, J. Dedrick, additional, Joseph, Jomon, additional, Justement, Louis B., additional, Kafri, Yariv, additional, Kahn, Richard A., additional, Kang, Shin W., additional, Karlin, Arthur, additional, Kast-Woelbern, Heidi R., additional, Kaufman, Randal J., additional, Kazlauskas, Andrius, additional, Keen, James H., additional, Kemler, Rolf, additional, Kemp, Bruce E., additional, Kennedy, Mary B., additional, Kennedy, Matthew A., additional, Kikkawa, Ushio, additional, Kim, Albert H., additional, Kim, Soo-A, additional, Kim, Sung-Hou, additional, Kim, Youngjoo, additional, King-Jones, Kirst, additional, Kintner, Chris, additional, Kivimäe, Saul, additional, Klee, Claude B., additional, Klein, Rüdiger, additional, Kleppisch, Thomas, additional, Kliewer, Steven A., additional, Klinghoffer, Richard A., additional, Knoblich, Juergen A., additional, Kobe, Bostjan, additional, Kochs, George, additional, Kong-Beltran, Monica, additional, König, Rolf, additional, Koong, Albert C., additional, Korc, Murray, additional, Kornitzer, Daniel, additional, Kossiakoff, Anthony A., additional, Kotera, Jun, additional, Kovalenko, M.V., additional, Kozasa, Tohru, additional, Kozlov, Sergei, additional, Kozminski, Keith G., additional, Krugmann, Sonja, additional, Kuriyan, John, additional, Kurokawa, Riki, additional, Kwong, Peter D., additional, Lai, Wi S., additional, Lamar, Elise, additional, Lambert, Millard H., additional, Lambright, David G., additional, Lancet, Doron, additional, Landry, Reiko, additional, Langdon, Wallace Y., additional, Langeberg, Lorene K., additional, Lasko, Paul, additional, Latham, Vaughn, additional, Lavin, Martin F., additional, Lease, Kevin A., additional, Leffler, Hakon, additional, Lemmon, Mark A., additional, Leonard, Ann E., additional, Levitzki, Alexander, additional, Liao, Hong-Jun, additional, Liaw, Lucy, additional, Liberi, Giordano, additional, Lickert, Heiko, additional, Liddington, Robert C., additional, Lincoln, Thomas M., additional, Linder, Jürgen U., additional, Linder, Maurine E., additional, Liu, Hui, additional, Liu, Zhengchang, additional, Lohela, Marja K., additional, Louie, Sarah H., additional, Luttrell, Deirdre K., additional, Luttrell, Louis M., additional, Lyons, Karen M., additional, Macaulay, S. Lance, additional, Maceyka, Michael, additional, Maciag, Thomas, additional, Macian, Fernando, additional, MacKintosh, Carol, additional, MacLennan, David H., additional, Mahmood, Nadir A., additional, Malbon, Craig C., additional, Malik, Sohail, additional, Man, Orna, additional, Manahan, Carol L., additional, Mandinova, Anna, additional, Manganiello, Vincent C., additional, Manley, James L., additional, Mann, Matthias, additional, Manning, Gerald, additional, Manser, Ed, additional, Margeta-Mitrovic, Marta, additional, Margolskee, Robert F., additional, Marinissen, Julia, additional, Mariuzza, Roy A., additional, Marmor, Mina D., additional, Martin, G. Steven, additional, Martin, Karen H., additional, Martinez, Sergio E., additional, Mathews, Michael B., additional, Mayer, Bruce J., additional, Mayer, Mark L., additional, Mazzoni, Maria R., additional, McCormick, Frank, additional, McGowan, Clare H., additional, McKay, Melissa M., additional, McKeehan, Wallace L., additional, McLean, Alison J., additional, Means, Anthony R., additional, Meili, Ruedi, additional, Meng, Jingwei, additional, Merchant, Mark, additional, Mercurio, Frank, additional, Milligan, Graeme, additional, Ming, Guo-Li, additional, Minor, Daniel L., additional, Moghal, Nadeem, additional, Møller, Neils Peter H., additional, Mongillo, Marco, additional, Montminy, Marc, additional, Moon, Randall T., additional, Morimoto, Richard I., additional, Moss, Stephen E., additional, Mott, Helen R., additional, Mouta, Carla, additional, Muda, Marco, additional, Mumby, Marc C., additional, Murphy, Gretchen A., additional, Muzi-Falconi, Marco, additional, Nagaraj, Raghavendra, additional, Nahorski, Stefan R., additional, Nairn, Angus C., additional, Nash, Piers, additional, Neel, Benjamin G., additional, Newton, Alexandra C., additional, Nishizuka, Yasutomi, additional, Noel, Joseph P., additional, Nollen, Ellen A.A., additional, Nooren, Irene M.A., additional, O'Connor, Rodney, additional, Offermanns, Stefan, additional, Olender, Tsviya, additional, Ong, Shao-En, additional, Owen, Darerca, additional, Pagliari, Lisa J., additional, Pao, Lily, additional, Papaconstantinou, John, additional, Pardo, Leonardo, additional, Park, Hay-Oak, additional, Park, Young Chul, additional, Parker, Peter J., additional, Parsons, J. Thomas, additional, Passner, J.M., additional, Pawson, Tony, additional, Pelliccioli, Achille, additional, Perez-Polo, J. Regino, additional, Perrimon, Norbert, additional, Petite, Fabrice G., additional, Petroulakis, Emmanuel, additional, Pfaff, Samuel L., additional, Piehler, Jacob, additional, Pike, Linda J., additional, Pinkoski, Michael J., additional, Pixley, Fiona J., additional, Plevani, Paolo, additional, Poo, Mu-ming, additional, Pozzan, Tullioi, additional, Prescott, Stephen M., additional, Prudovsky, Igor, additional, Putney, James W., additional, Radimerski, Thomas, additional, Radzio-Andzelm, Elzbieta, additional, Ram, Prahlad T., additional, Rameh, Lucia, additional, Ramljak, Danica, additional, Ranscht, Barbara, additional, Rao, Anjana, additional, Raport, Carol J., additional, Reeves, Jacqueline D., additional, Rehman, Holger, additional, Reichman, Trevor W., additional, Reiter, Eric, additional, Resnick, Michael A., additional, Reth, Michael, additional, Rhee, Sue Goo, additional, Richter, Joel D., additional, Rietze, Rodney L., additional, Rini, James M., additional, Ripperger, Jürgen A., additional, Rizo, Josep, additional, Robishaw, Janet D., additional, Roderick, H. Llewelyn, additional, Roeder, Robert G., additional, Rohrschneider, Larry R., additional, Ron, David, additional, Rosenfeld, Michael G., additional, Rosenfeldt, Hans, additional, Rossman, Kent L., additional, Roth, Christopher B., additional, Rudolph, Markus G., additional, Ruppelt, Anja, additional, Saez, Lino, additional, Sakmar, Thomas P., additional, Salvesen, Guy S., additional, Sassone-Corsi, Paolo, additional, Saxe, Charles L., additional, Schäfer, Beat W., additional, Schibler, Ueli, additional, Schindler, Christian W., additional, Schmelzle, Tobias, additional, Schmid, Sandra L., additional, Schmidt, Anja, additional, Schmidt, Eric F., additional, Schreiber, Gideon, additional, Schultz, Joachim E., additional, Schwaller, Beat, additional, Schwamborn, Klaus, additional, Schwartz, Thue, additional, Schwindinger, William F., additional, Scita, Giorgio, additional, Scott, John D., additional, Scott, Shaun, additional, Seebeck, Thomas, additional, Serhan, Charles N., additional, Shabb, John B., additional, Shaw, Andrey S., additional, Shears, Stephen B., additional, Shenolikar, Shirish, additional, Shi, Lei, additional, Shin, Chanseok, additional, Shiozaki, Kazuhiro, additional, Shokat, Kevan M., additional, Shuttleworth, Trevor J., additional, Siderovski, David P., additional, Siegelbaum, Steven A., additional, Silverstein, Adam M., additional, Singer, Robert H., additional, Skinner, Michael K., additional, Slack-Davis, Jill K., additional, Smerdon, Stephen J., additional, Smith, Graeme C.M., additional, Smits, Guillaume, additional, Smolik, Sarah M., additional, Smotrys, Jessica E., additional, Smyth, Emer M., additional, Snyder, Jason T., additional, Sogame, Naoko, additional, Soldi, Raffaella, additional, Sondek, John, additional, Sonenberg, Nahum, additional, Sonneberg, Erica Dutil, additional, Sparrow, Lindsay G., additional, Spiegel, Sarah, additional, Sprang, Stephen R., additional, Srivastava, Deepak, additional, Stanfield, Robyn L., additional, Stanley, E. Richard, additional, Stauber, Deborah J., additional, Stefan, Christopher, additional, Stenson-Holst, Lena, additional, Stephens, Len, additional, Sternberg, Paul W., additional, Sternweis, Paul C., additional, Steward, Ruth, additional, Stickney, John T., additional, Stoker, Andrew W., additional, Strittmatter, Stephen M., additional, Stronach, Beth E., additional, Strong, Roland K., additional, Stroud, Robert M., additional, Südhof, Thomas C., additional, Sunahara, Roger K., additional, Sutton, Brian J., additional, Szabolcs, Sipeki, additional, Tang, Xiao-Bo, additional, Taskén, Kjetil, additional, Tatebe, Hisashi, additional, Tauszig-Delamasure, Servane, additional, Taylor, Colin W., additional, Taylor, Garry L., additional, Taylor, Laura J., additional, Taylor, Susan S., additional, Thomas, George, additional, Thomas, Robert P., additional, Thompson, E. Brad, additional, Thompson, Michael J., additional, Thornton, Janet M., additional, Thummel, Carl S., additional, Togashi, Hideaki, additional, Tong, Amy Hin Yan, additional, Tonks, Nicholas K., additional, Tontonoz, Peter, additional, Topham, M.K., additional, Torgersen, Knut Martin, additional, Tran, Hien, additional, Tremblay, Michel L., additional, Tsai, Ming-Jer, additional, Tsai, Sophia Y., additional, Tsunoda, Susan, additional, Turley, Stewart, additional, Tyson, Darren, additional, Van Etten, Robert L., additional, Vassart, Gilbert, additional, Verveer, Peter J., additional, Vlaeminck, Virginie, additional, de Vos, Abraham M., additional, Voss, Ty C., additional, Walczak, Robert, additional, Walker, Graham C., additional, Walker, John C., additional, Walter, Gernot, additional, Walter, Mark R., additional, Wang, Fen, additional, Wang, Jean Y.J., additional, Wang, Weiru, additional, Ward, Richard J., additional, Wedegaertner, Philip, additional, Wehrle, Christian, additional, Weiss, Arthur, additional, Weiss, Jamie L., additional, Wells, Alan, additional, Werner, Claudia, additional, West, Ann H., additional, Weston, Marie C., additional, Westwick, John K., additional, Wetterholm, Anders, additional, White, Morris F., additional, Whitman, Malcolm, additional, Whorton, Matt R., additional, Wiesmann, Christian, additional, Williams, Roger L., additional, Willis, William D., additional, Willson, Timothy M., additional, Wilson, Ian A., additional, Wiser, Ofer, additional, Wishart, Matthew J., additional, Wittinghofer, Alfred, additional, Woodgett, James R., additional, Worthylake, David K., additional, Wrana, Jeffrey L., additional, Wu, Hao, additional, Xiao, Yijin, additional, Xu, H. Eric, additional, Xu, Yan, additional, Xu, Zheng, additional, Yaffe, Michael B., additional, Yamada, Kenneth M., additional, Yang, Seun-Ah, additional, Yang, Wannian, additional, Yarden, Yosef, additional, Ye, Hong, additional, Ye, Weilan, additional, Yeates, Todd O., additional, Yin, Helen L., additional, York, John D., additional, Young, Edgar C., additional, Young, Kenneth W., additional, Young, Matthew A., additional, Young, Michael W., additional, Yu, Minmin, additional, Zaccai, Nathan R., additional, Zaccolo, Manuela, additional, Zamir, Eli, additional, von Zastrow, Mark, additional, Zhang, Chao, additional, Zhang, Xuewu, additional, Zhang, Zhong-Yin, additional, Zhou, Wenhong, additional, and Zoraghi, Roya, additional

Published
2003
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79. A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts

Author

Dustin, Michael L., Olszowy, Michael W., Holdorf, Amy D., Li, Jun, Bromley, Shannon, Desai, Naishadh, Widder, Patricia, Rosenberger, Frederick, Merwe, P. Anton van der, Allen, Paul M., and Shaw, Andrey S.

Subjects
T cells -- Research, Proteins -- Research, Antigen receptors, T cell -- Research, Cytoskeleton -- Research, Biological sciences
Abstract

A study showed that CD2 binding to ligand results to protein segregation, CD2 clustering and T cell polarization. The protein segregation is independent of the cytoplasmic domain of CD2, while the CD2 clustering and cytoskeleton polarization are mediated by binding of the CD2 cytoplasmic domain with a new SH3-containing protein called CD2-associated protein (CD2AP). These indicate that the CD2AP seems to promote receptor patterning and cytoskeletal polarization in the T cell contact area.

Published
1998

80. Fidelity of T cell activation through multistep T cell receptor-zeta phosphorylation

Author

Kersh, Ellen Neumeister, Shaw, Andrey S., and Allen, Paul M.

Subjects
T cells -- Receptors, Antigen receptors, T cell -- Physiological aspects, Phosphorylation -- Physiological aspects, Science and technology, Physiological aspects
Abstract

The T cell receptor (TCR) [Alpha]Β heterodimer interacts with its ligands with high specificity, but surprisingly low affinity. The role of the [Zeta] component of the murine TCR in contributing to the fidelity of antigen recognition was examined. With sequence-specific phosphotyrosine antibodies, it was found that [Zeta] undergoes a series of ordered phosphorylation events upon TCR engagement. Completion of phosphorylation steps is dependent on the nature of the TCR ligand. Thus, the phosphorylation steps establish thresholds for T cell activation. This study documents the sophisticated molecular events that follow the engagement of a low-affinity receptor., The [Alpha]Β TCR is part of a large protein complex composed of the CD3 [Gamma] Δ, [Epsilon], and [Zeta] chains. These chains contain signaling motifs called ITAMs (immune receptor tyrosinebased [...]

Published
1998

82. Multiple features of the p59(super fyn) src homology 4 domain define a motif for immune-receptor tyrosine-based activation motif (ITAM) binding and for plasma membrane localization

Author

Gauen, Lisa K. Timson, Linder, Maurine E., and Shaw, Andrey S.

Subjects
Protein tyrosine kinase -- Research, Plasma membranes -- Research, Amino acids -- Analysis, Cooperative binding (Biochemistry) -- Research, Biological sciences
Abstract

The fatty acylation and plasma membrane targeting characteristics of p59(super fyn) are responsible for the ability of the src homology (SH) 4 domain to bind to TCR proteins. Four amino acid residues are necessary for the proper binding of p59(super fyn) to TCR. The amino acids are present in p59(super fyn) and other src family of tyrosine kinases that bind to the immune-receptor tyrosine-based activation motif. The amino acids are also necessary for proper fatty acylation and plasma membrane targeting.

Published
1996

83. Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy

Author

Sloan-Lancaster, Joanne, Shaw, Andrey S., Rothbard, Jonathan B., and Allen, Paul M.

Subjects
T cells -- Receptors, Cellular signal transduction -- Analysis, Phosphorylation -- Analysis, Biological sciences
Abstract

Analysis of intracellular signal transduction after activation by anergy-inducing altered peptide ligands (APLs) and of the phosphorylation patterns reveals that anergy-inducing APL does not cause protein-tyrosine phosphorylation, indicating the stimulation of selective signal transduction pathways by APL. APL stimulation induces a characteristic T cell receptor (TCR) zeta chain phosphorylation and inhibits its correlation to the zap70 protein-tyrosine kinase. The TCR-CD3 complex thus associates with selective intracellular biochemical signaling pathways, resulting in anergic T cell phenotype.

Published
1994

84. Distinct p53/56-lyn and p59-fyn domains associate with nonphosphorylated and phosphorylated Ig-alpha

Author

Pleiman, Christopher M., Abrams, Charles, Gauen, Lisa Timson, Bedzyk, William, Jongstra, Jan, Shaw, Andrey S., and Cambier, John C.

Subjects
Immunoglobulins -- Physiological aspects, Tyrosine metabolism -- Analysis, Protein tyrosine kinase -- Physiological aspects, Science and technology
Abstract

A study of distinct p53/56-lyn and p59-fyn domains related to nonphosphorylated and phosphorylated Ig-alpha revealed a mechanism by which ligand-induced Ig-alpha phosphorylation stimulated a change in the orientation of an associated tyrosine kinase. This change altered kinase activity and/or access to effectors and substrates. The kinases interacted with B-cell antigen receptor complexes through the Ig-alpha chain antigen receptor homology 1 motif.

Published
1994

94. Gremlin 1+fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues

Author

Kapoor, Varun N., Müller, Sören, Keerthivasan, Shilpa, Brown, Markus, Chalouni, Cecile, Storm, Elaine E., Castiglioni, Alessandra, Lane, Ryan, Nitschke, Maximilian, Dominguez, Claudia X., Astarita, Jillian L., Krishnamurty, Akshay T., Carbone, Catherine B., Senbabaoglu, Yasin, Wang, Amber W., Wu, Xiumin, Cremasco, Viviana, Roose-Girma, Merone, Tam, Lucinda, Doerr, Jonas, Chen, Mark Z., Lee, Wyne P., Modrusan, Zora, Yang, Yeqing Angela, Bourgon, Richard, Sandoval, Wendy, Shaw, Andrey S., de Sauvage, Frederic J., Mellman, Ira, Moussion, Christine, and Turley, Shannon J.

Abstract

Fibroblastic reticular cells (FRCs) are specialized stromal cells that define tissue architecture and regulate lymphocyte compartmentalization, homeostasis, and innate and adaptive immunity in secondary lymphoid organs (SLOs). In the present study, we used single-cell RNA sequencing (scRNA-seq) of human and mouse lymph nodes (LNs) to identify a subset of T cell–zone FRCs defined by the expression of Gremlin1 (Grem1) in both species. Grem1-CreERT2knock-in mice enabled localization, multi-omics characterization and genetic depletion of Grem1+FRCs. Grem1+FRCs primarily localize at T–B cell junctions of SLOs, neighboring pre-dendritic cells and conventional dendritic cells (cDCs). As such, their depletion resulted in preferential loss and decreased homeostatic proliferation and survival of resident cDCs and compromised T cell immunity. Trajectory analysis of human LN scRNA-seq data revealed expression similarities to murine FRCs, with GREM1+cells marking the endpoint of both trajectories. These findings illuminate a new Grem1+fibroblastic niche in LNs that functions to maintain the homeostasis of lymphoid tissue-resident cDCs.

Published
2021
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99. Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling

Author

Goncharov, Tatiana, primary, Hedayati, Stefanie, additional, Mulvihill, Melinda M., additional, Izrael-Tomasevic, Anita, additional, Zobel, Kerry, additional, Jeet, Surinder, additional, Fedorova, Anna V., additional, Eidenschenk, Celine, additional, deVoss, Jason, additional, Yu, Kebing, additional, Shaw, Andrey S., additional, Kirkpatrick, Donald S., additional, Fairbrother, Wayne J., additional, Deshayes, Kurt, additional, and Vucic, Domagoj, additional

Published
2018
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100. Opposing Roles of Dendritic Cell Subsets in Experimental GN

Author

Brähler, Sebastian, primary, Zinselmeyer, Bernd H., additional, Raju, Saravanan, additional, Nitschke, Maximilian, additional, Suleiman, Hani, additional, Saunders, Brian T., additional, Johnson, Michael W., additional, Böhner, Alexander M.C., additional, Viehmann, Susanne F., additional, Theisen, Derek J., additional, Kretzer, Nicole M., additional, Briseño, Carlos G., additional, Zaitsev, Konstantin, additional, Ornatsky, Olga, additional, Chang, Qing, additional, Carrero, Javier A., additional, Kopp, Jeffrey B., additional, Artyomov, Maxim N., additional, Kurts, Christian, additional, Murphy, Kenneth M., additional, Miner, Jeffrey H., additional, and Shaw, Andrey S., additional

Published
2017
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