270 results on '"Sheehy, T."'
Search Results
52. Carotid sinus massage -- how safe is it?
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Walsh T, Clinch D, Costelloe A, Moore A, Sheehy T, Watts M, Bryant CA, Close J, Gonzalez J, Ouldred E, Pathansali R, Swift CG, Lyons D, and Jackson SH
- Published
- 2006
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53. How Much Folic Acid Is Safe in Pernicious Anemia?
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SHEEHY, T. W.
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- 1961
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54. The Effect of "Minute" and "Titrated" Amounts of Folic Acid on the Megaloblastic Anemia of Tropical Sprue
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SHEEHY, T. W., RUBINI, M. E., PEREZ-SANTIAGO, E., SANTINI, R., and HADDOCK, J.
- Abstract
A therapeutic trial with "minute" and "titrated" doses of folic acid was performed in 30 patients with the megaloblastic anemia of tropical sprue. Eleven patients responded hematologically to 25 µg. daily doses of the vitamin; nine patients responded to "titrated" doses ranging from 75 to 250 µg. daily. Eleven patients failed to respond to either "minute" or "titrated" doses of the vitamin. The implications and possible reasons for the success or failure of microdoses of folic acid in sprue were discussed.
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- 1961
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55. Tropical Sprue and Vitamin B12
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Sheehy, T. W., Perez-Santiago, E., Rubini, M. E., and Fradera, F. E.
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- 1961
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56. Readers report.
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Riley, Rebecca J., Avery, Vernon, Hammer, Samuel, Belden, David L., Feeley, Ann, Howard, Bill, Banca, Peter A., Wolfe, Thomas E., Sheehy, T. R., Sheinbein, Melvyn M., and Hastie, Frank
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LETTERS to the editor ,BUSINESSWOMEN ,SCIENTISTS ,UNEMPLOYMENT insurance - Abstract
Several letters to the editor are presented in response to articles in previous issues including "The Industrial Salesman Becomes a SalesPerson," in the February 19, 1979 issue, "Why Soviet Technology Is Lagging," by Robert Wesson in the February 26, 1979 issue, and "Troubles Multiply for the 1980 Census" in the February 26, 1979 issue.
- Published
- 1979
57. Geotrichum septicemia
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Sheehy, T. W., primary
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- 1976
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58. Apathetic thyrotoxicosis causing gastrointestinal malabsorption
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Sheehy, T. W., primary
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- 1974
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59. Giardia-induced malabsorption in pancreatitis
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Sheehy, T. W., primary
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- 1975
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60. Treatment of sickle cell disease
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Sheehy, T. W., primary
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- 1977
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61. Exchange transfusion for sickle cell intrahepatic cholestasis
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Sheehy, T. W., primary
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- 1980
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62. Laboratory Vibrio cholerae infection in the United States
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Sheehy, T. W., primary
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- 1966
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63. Scrub typhus. A comparison of chloramphenicol and tetracycline in its treatment
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Sheehy, T. W., primary
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- 1973
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64. Computer aided shrouded propeller design
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SHEEHY, T., primary
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- 1973
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65. Tropical sprue in North Americans
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Sheehy, T. W., primary
- Published
- 1965
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66. Supplemental sulfone (dapsone) therapy. Use in treatment of chloroquine-resistant falciparum malaria
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Sheehy, T. W., primary
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- 1967
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67. Methotrexate therapy for Plasmodium vivax malaria
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Sheehy, T. W., primary
- Published
- 1970
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68. Metastatic melanoma complicated by disseminated BCG.
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HON, JEREMY K., HAMNER, RONALD W., BAILEY, WILLIAM C., SHEEHY, THOMAS W., Hon, J K, Hamner, R W, Bailey, W C, and Sheehy, T W
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- 1982
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69. Endgames.
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Thomas T, Saravanan B, Blake F, Fletcher J, Cooke J, Carew S, Costello A, Sheehy T, and Lyons D
- Published
- 2008
70. LOW BODY MASS INDEX IS ASSOCIATED WITH INCREASED ORTHOSTATIC HYPOTENSION AND OSTEOPOROSIS MAJOR FALLS AND FRACTURE RISKS.
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Pope, G., Carew, S., Saunders, J., Costelloe, A., Sheehy, T., and Lyons, D.
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GERIATRICS ,BODY mass index ,ORTHOSTATIC hypotension ,OSTEOPOROSIS ,HEALTH risk assessment of older people ,HEALTH of older people - Abstract
The article presents a study which examined the relationship between low body mass index (BMI) and increased risks of orthostatic hypotension (OH) and osteoporosis major falls and fracture. The relationship between BMI and hemodynamic changes on orthostatic stress along with the relationship between OH and systolic hypertension were investigated. Results revealed that low BMI is association with higher OH and osteoporosis risks.
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- 2008
71. Origins of intravenous fluid therapy.
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Sheehy, T W
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- *
CHOLERA treatment , *FLUID therapy , *HISTORY - Published
- 1989
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72. Malignant mesenchymoma of the cervixSimple excision followed by long-term survival
- Author
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SHEEHY, T
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- 1971
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73. Prospective evaluation of the relationship between cognition and recovery outcomes after cardiac arrest.
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Blennow Nordström E, Birk JL, Rojas DA, St Onge Sheehy T, Domínguez-Imbert Nieto CI, Cruz GJ, Ten Brink M, Vargas W, Karas M, and Agarwal S
- Abstract
Purpose: Cognitive function is often impaired for cardiac arrest (CA) survivors due to hypoxic-ischemic brain injury. Whether cognitive impairment at hospital discharge is associated with recovery defined as functional status and fatigue measured at 1-month post-discharge is not known., Methods: Consecutive CA patients admitted at an academic center (May 14, 2021-June 23, 2023) were assessed for cognitive impairment (modified Telephone Interview for Cognitive Status, TICS-m < 33) and depressive symptoms (8-item Patient Health Questionnaire) at hospital discharge. Poor functional status (primary outcome; modified Rankin Scale, mRS > 3) and fatigue severity (patient-reported outcome; Modified Fatigue Impact Scale) were assessed 1-month post-discharge. Hierarchical regressions tested associations of cognitive function with outcomes., Results: Of 112 participants (mean age 54.4 ± 14.8; 38% female; 43% White race, 20% Black race, 29% Hispanic ethnicity) completing discharge TICS-m, 63 (56%) had indicated cognitive impairment, and 68 (61%) had poor 1-month functional outcome. Worse discharge cognitive function was independently associated with a higher risk of poor 1-month functional outcome (OR = 0.88, 95% CI [0.79, 0.98], p = 0.02) after adjusting for age, education, sex, race, ethnicity, length of hospital stay, comorbidities, and depressive symptoms. Fatigue severity lacked significant associations with cognitive function, but was associated with depressive symptoms (B = 1.03 [0.00, 2.05], p = 0.04)., Conclusion: Cognitive function at discharge after CA was significantly and independently associated with functional outcome 1 month after hospital discharge. Psychological distress contributed to fatigue severity. This highlights the need for screening and addressing cognitive and emotional problems pre-hospital discharge., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)
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- 2024
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74. Programable Albumin-Hitchhiking Nanobodies Enhance the Delivery of STING Agonists to Potentiate Cancer Immunotherapy.
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Wilson J, Kimmel B, Arora K, Chada N, Bharti V, Kwiatkowski A, Finklestein J, Hanna A, Arner E, Sheehy T, Pastora L, Yang J, Pagendarm H, Stone P, Taylor B, Hubert L, Gibson-Corley K, May J, McLean J, Rathmell J, Richmond A, Rathmell W, Balko J, Fingleton B, and Hargrove-Wiley E
- Abstract
Stimulator of interferon genes (STING) is a promising target for potentiating antitumor immunity, but multiple pharmacological barriers limit the clinical utility, efficacy, and/or safety of STING agonists. Here we describe a modular platform for systemic administration of STING agonists based on nanobodies engineered for in situ hitchhiking of agonist cargo on serum albumin. Using site-selective bioconjugation chemistries to produce molecularly defined products, we found that covalent conjugation of a STING agonist to anti-albumin nanobodies improved pharmacokinetics and increased cargo accumulation in tumor tissue, stimulating innate immune programs that increased the infiltration of activated natural killer cells and T cells, which potently inhibited tumor growth in multiple mouse tumor models. We also demonstrated the programmability of the platform through the recombinant integration of a second nanobody domain that targeted programmed cell death ligand-1 (PD-L1), which further increased cargo delivery to tumor sites while also blocking immunosuppressive PD-1/PD-L1 interactions. This bivalent nanobody carrier for covalently conjugated STING agonists stimulated robust antigen-specific T cell responses and long-lasting immunological memory, conferred enhanced therapeutic efficacy, and was effective as a neoadjuvant treatment for improving responses to adoptive T cell transfer therapy. Albumin-hitchhiking nanobodies thus offer an enabling, multimodal, and programmable platform for systemic delivery of STING agonists with potential to augment responses to multiple immunotherapeutic modalities., Competing Interests: Competing Interests J.T.W., K.A., and B.R.K. are inventors on U.S. Provisional Application No. 63/472,528 “NANOBODY-DRUG CONJUGATES AND METHODS OF PREPARING THEREOF” which describes nanobody conjugation and delivery technologies. W.K.R. is an employee of Vanderbilt University Medical Center and appointed to the Vanderbilt University School of Medicine. She has received research support from Incyte Corp. within the past three years, and serves on the Board of Scientific Advisors for the National Cancer Institute. J.C.R. is an employee of Vanderbilt University Medical Center and appointed to the Vanderbilt University School of Medicine. He is a founder, scientific advisory board member, and stockholder of Sitryx Therapeutics, a scientific advisory board member and stockholder of Caribou Biosciences and holds stock options for Nirogy Therapeutics. He has consulted and received speaker fees from Merck, Pfizer, and Abbie. He has received research support from Incyte Corp. within the past three years. J.M.B. receives research support from Genentech/Roche and Incyte Corporation, has received advisory board payments from AstraZeneca and Mallinckrodt and is an inventor on patents regarding immunotherapy targets and biomarkers in cancer.
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- 2024
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75. Delirium and abnormal autonomic nervous system response to head-up tilt testing.
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Shanahan E, Ryan S, Leahy A, Sheehy T, Costelloe A, Roy A, Galvin R, Peters C, Lyons D, and O'Connor M
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- Aged, 80 and over, Autonomic Nervous System, Blood Pressure, Humans, Prospective Studies, Tilt-Table Test, Delirium diagnosis, Hypotension, Orthostatic
- Abstract
Background: Delirium is a common condition with poorly understood pathophysiology. Various theories have been proposed including that delirious patients have reduced cerebral blood flow. We hypothesised that patients with delirium could have abnormal autonomic nervous system function, as assessed by tilt table testing, which would explain the alteration in blood flow., Methods: A prospective cohort study of medical inpatients aged 65 years and older was undertaken. Delirium was assessed using DRS-R98 and DSM-IV criteria. Beat-to-beat blood pressure (BP) was recorded during tilt testing. Differences in BP changes between the two groups (those with delirium and those without) were explored. The association between severity of delirium and magnitude of BP changes was also examined., Results: 64 participants were recruited during hospitalisation. 29 completed follow-up Head-Up Tilt testing. The mean age of participants was 80.8 years (SD 6.2 years). The control group (n = 12) had a median decrease in systolic BP of 17.5 mmHg (IQR 20.75). The delirium group (n = 17) had a median decrease in systolic BP of 1 mmHg (IQR 38.5), p = 0.04. As delirium severity scores increased, systolic BP change during tilting also increased (r
s = 0.42, p = 0.03)., Conclusion: Participants in the delirium group showed different BP responses to tilt test which may represent abnormal sympathetic response. This would be consistent with other features of delirium such as treatment response to centrally acting alpha-2 blockers. Equity of access to research for older, frail and delirious cohorts is essential but feasibility and acceptability needs to be optimised and factored into study design., (Copyright © 2021 Elsevier Inc. All rights reserved.)- Published
- 2021
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76. Trends in energy and nutrient supply in Ethiopia: a perspective from FAO food balance sheets.
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Sheehy T, Carey E, Sharma S, and Biadgilign S
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- Dietary Carbohydrates administration & dosage, Dietary Fats administration & dosage, Dietary Proteins administration & dosage, Ethiopia, Humans, Micronutrients administration & dosage, Diet methods, Diet statistics & numerical data, Energy Intake, Food Supply methods, Food Supply statistics & numerical data, Nutrition Surveys statistics & numerical data
- Abstract
Background: Ethiopia is the second-most populous country in Africa. Although most people still live in rural areas, the urban population is increasing. Generally, urbanisation is associated with a nutrition transition and an increase in risk factors for non-communicable diseases (NCDs). The objective of this study was to determine how the nutritional composition of the Ethiopian food supply has changed over the last 50 years and whether there is evidence of a nutrition transition., Methods: Food balance sheets for Ethiopia from 1961 to 2011 were downloaded from the FAOSTAT database and daily per capita supply for 17 commodity groupings was calculated. After appropriate coding, per capita energy and nutrient supplies were determined., Results: Per capita energy supply was 1710 kcal/d in 1961, fell to 1403 kcal/d by 1973, and increased to 2111 kcal/d in 2011. Carbohydrate was by far the greatest energy source throughout the period, ranging from 72% of energy in 1968 to 79% in 1998; however, this was mostly provided by complex carbohydrates as the contribution of sugars to energy only varied between 4.7% in 1994 and 6.7% in 2011. Energy from fat was low, ranging from 14% of energy in 1970 to 10% in 1998. Energy from protein ranged from 14% in 1962 to 11% in 1994. Per capita supplies of calcium, vitamin A, C, D, folate and other B-vitamins were insufficient and there was a low supply of animal foods., Conclusions: The Ethiopian food supply is still remarkably high in complex carbohydrates and low in sugars, fat, protein, and micronutrients. There is little evidence yet of changes that are usually associated with a nutrition transition.
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- 2019
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77. Is vitamin D deficiency a public health concern for low middle income countries? A systematic literature review.
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Cashman KD, Sheehy T, and O'Neill CM
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- Humans, Vitamin D Deficiency diagnosis, Vitamin D Deficiency therapy, Developing Countries statistics & numerical data, Public Health methods, Vitamin D Deficiency epidemiology
- Abstract
Purpose: Vitamin D deficiency has been receiving increasing attention as a potential public health concern in low and lower-middle income countries (LMICs), of which there are currently 83. We aimed to conduct a comprehensive systematic literature review (SLR) of available data on vitamin D status and prevalence of vitamin D deficiency in all 83 LMICs., Methods: We followed the general methodology for SLRs in the area of serum 25-hydroxyvitamin D. Highest priority was placed on identifying relevant population-based studies, followed by cross-sectional studies, and to a lesser extent case-control studies. We adopted the public health convention that a prevalence of vitamin D deficiency (serum 25-hydroxyvitamin D < 25/30 nmol/L) at > 20% in the entire population and/or at-risk population subgroups (infants, children, women of child-bearing age, pregnancy) constitutes a public health issue that may warrant intervention., Results: Our SLR revealed that of the 83 LMICs, 65% (n = 54 countries) had no published studies with vitamin D data suitable for inclusion. Using data from the remaining third, a number of LMICs had evidence of excess burden of vitamin D deficiency in one or more population subgroup(s) using the above convention (Afghanistan, Pakistan, India, Tunisia and Mongolia) as well as possibly other LMICs, albeit with much more limited data. Several LMICs had no evidence of excess burden., Conclusion: Vitamin D deficiency is a public health issue in some, but certainly not all, LMICs. There is a clear need for targeting public health strategies for prevention of vitamin D deficiency in those LMICs with excess burden.
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- 2019
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78. Changes in Weight Loss, Health Behaviors, and Intentions among 400 Participants Who Dropped out from an Insurance-Sponsored, Community-Based Weight Management Program.
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Zizzi SJ, Lima Fogaca J, Sheehy T, Welsh M, and Abildso C
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- Adult, Aged, Community Health Services, Female, Health Promotion organization & administration, Humans, Insurance Carriers, Male, Middle Aged, Surveys and Questionnaires, West Virginia, Young Adult, Health Behavior, Obesity prevention & control, Patient Dropouts, Weight Loss
- Abstract
The majority of weight management research is based on data from randomized controlled studies conducted in clinical settings. As these findings are translated into community-based settings, additional research is needed to understand patterns of lifestyle change and dropout. The purpose of this study was to examine reasons for and consequences associated with dropout (or removal) from an insurance-funded weight management program. Using a mixed methods approach with objectively measured changes in body weight and attendance along with quantitative and qualitative survey data, patterns of intention and behavior change were explored. The results from a sample of 400 respondents support the idea that there are both positive and negative consequences of program participation. Overall, 1 in 5 respondents lost a clinically significant amount of weight during the program (>5% of baseline body weight) and 1 in 3 experienced a positive consequence, while only 6% expressed a negative outcome of participation. Additionally, nearly 90% of all of the consequences that emerged from the data were positive. Attitude change was a major theme, including positive health intentions, perceived success, learning skills, and new appreciation of exercise.
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- 2016
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79. Food and Nutrient Intake in African American Children and Adolescents Aged 5 to 16 Years in Baltimore City.
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Kolahdooz F, Butler JL, Christiansen K, Diette GB, Breysse PN, Hansel NN, McCormack MC, Sheehy T, Gittelsohn J, and Sharma S
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- Adolescent, Black or African American, Baltimore, Child, Child, Preschool, Diet Records, Female, Food Analysis, Humans, Male, Poverty, Diet, Feeding Behavior
- Abstract
Objective: This study aimed to describe food and nutrient intake for low-income, urban African American children and adolescents, to highlight the need for further nutrition intervention programs and appropriate tools to address overweight and obesity., Methods: This was a cross-sectional study using interviewer-administered single 24-hour dietary recalls. Participants were low-income African American boys and girls aged 5-16 years or their caregivers in Baltimore City. Frequency of food consumption and dietary intakes were analyzed by gender and age groups., Results: Eighty-one participants were included for analysis. Mean daily energy intakes exceeded Dietary Reference Intakes (DRIs) from 10% to 71% across all gender-age groups: 2304 kcal for children aged 5-8 years; 2429 kcal and 2732 kcal for boys and girls aged 9-13 years, respectively; and 3339 kcal and 2846 kcal for boys and girls aged 14-16 years, respectively. The most frequently reported consumed foods were sweetened drinks, chips, candies, and milk across all age groups. The majority of participants (79-100%) did not meet the DRIs for dietary fiber and vitamin E across all gender-age groups. Milk accounted for 14%, 17%, and 21% of energy, fat, and protein intake, respectively, among children 5-8 years of age, while pizza was the top source of energy, fat, and protein (11%, 13%, and 18%, respectively) among 14-to 16-year-old adolescents. Sweetened drinks and sweetened juices were major sources of sugar, contributing 33% for 5-8 year olds, 29% for 9-13 year olds, and 35% for 14-16 year olds., Conclusions: Mean daily energy intake exceeded dietary recommendations across all gender-age groups. This study has provided previously unavailable information on diet and highlights foods to be targeted in nutrition intervention programs.
- Published
- 2016
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80. Traditional food consumption is associated with better diet quality and adequacy among Inuit adults in Nunavut, Canada.
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Sheehy T, Kolahdooz F, Roache C, and Sharma S
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- Adult, Cross-Sectional Studies, Energy Intake, Female, Humans, Male, Nunavut, Nutritive Value, Surveys and Questionnaires, Culture, Diet methods, Diet statistics & numerical data, Feeding Behavior, Inuit statistics & numerical data, Nutritional Status
- Abstract
The Inuit population is undergoing a rapid nutrition transition as a result of reduced consumption of traditional foods. This study aims to describe the differences in dietary adequacy between non-traditional and traditional eaters among Inuit populations in Nunavut, Canada. A cross-sectional survey was conducted using a culturally appropriate quantitative food frequency questionnaire. Participants included 208 Inuit adults from three isolated communities in Nunavut. Traditional eaters consumed a more nutrient-dense diet and achieved better dietary adequacy than non-traditional eaters. Traditional foods accounted for 7 and 27% of energy intake among non-traditional and traditional eaters, respectively. Non-nutrient-dense foods accounted for a greater proportion of energy intake in non-traditional eaters; however, these were consumed in significant amounts by both the groups (36 and 27% of total energy). Consumption of traditional foods is associated with greater diet quality and dietary adequacy. Efforts should be made to promote traditional and non-traditional foods of high-nutritional quality.
- Published
- 2015
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81. Changing dietary patterns in the Canadian Arctic: frequency of consumption of foods and beverages by inuit in three Nunavut communities.
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Sheehy T, Kolahdooz F, Roache C, and Sharma S
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- Adult, Animals, Arctic Regions, Beverages, Body Mass Index, Canada, Cross-Sectional Studies, Diet ethnology, Dietary Fats, Dietary Sucrose, Edible Grain, Female, Food Preferences ethnology, Fruit, Humans, Male, Meat, Middle Aged, Nunavut, Surveys and Questionnaires, Vegetables, Diet trends, Inuit
- Abstract
Background: Inuit in Arctic regions are experiencing a rapid diet and lifestyle transition. There are limited data on food consumption patterns among this unique population, raising concerns about assessing the risk for the development of diet-related chronic diseases., Objective: To assess the current frequency of consumption of foods and beverages among Inuit in Nunavut, Arctic Canada., Methods: A cross-sectional dietary study was conducted among randomly selected Inuit adults from three communities in Nunavut using a validated quantitative food frequency questionnaire. The participants were 175 women and 36 men with median (IQR) ages of 41.0 (32.5-48.5) and 40.1 (30.0-50.0) years, respectively. The mean and median frequencies of consumption over a 30-day period were computed for 147 individual food items and grouped as foods or beverages., Results: The 30 most frequently consumed foods were identified. Non-nutrient-dense foods (i.e., high-fat and high-sugar foods) were the most frequently consumed food group (median intake, 3.4 times/day), followed by grains (2.0 times/day) and traditional meats (1.7 times/day). The frequency of consumption of fruits (0.7 times/day) and vegetables (0.4 times/day) was low. The median values for the three most frequently consumed food items were sugar or honey (once/day), butter (0.71 times/day), and Coffee-mate (0.71 times/day). Apart from water, coffee, and tea, the most frequently consumed beverages were sweetened juices (0.71 times/day) and regular pop (soft drinks) (0.36 times/day). This study showed that non-nutrient-dense foods are consumed most frequently in these Inuit communities., Conclusions: The results have implications for dietary quality and provide useful information on current dietary practices to guide nutritional intervention programs.
- Published
- 2014
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82. Food expenditure patterns in the Canadian Arctic show cause for concern for obesity and chronic disease.
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Pakseresht M, Lang R, Rittmueller S, Roache C, Sheehy T, Batal M, Corriveau A, and Sharma S
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- Adult, Body Mass Index, Chronic Disease, Edible Grain economics, Energy Intake, Family Characteristics, Female, Fruit economics, Humans, Male, Meat economics, Middle Aged, Northwest Territories, Nunavut, Nutritional Status, Vegetables economics, Diet economics, Feeding Behavior, Food economics, Obesity economics
- Abstract
Background: Little is understood about the economic factors that have influenced the nutrition transition from traditional to store-bought foods that are typically high in fat and sugar amongst people living in the Canadian Arctic. This study aims to determine the pattern of household food expenditure in the Canadian Arctic., Method: Local food prices were collected over 12 months in six communities in Nunavut and the Northwest Territories. Dietary intake data were collected from 441 adults using a validated quantitative food frequency questionnaire. Money spent on six food groups was calculated along with the cost of energy and selected nutrients per person., Results: Participants spent approximately 10% of total food expenditure on each of the food groups of fruit/vegetables, grains and potatoes, and dairy, 17% on traditional meats (e.g. caribou, goose, char, and seal liver), and 20% on non-traditional meats (e.g. beef, pork, chicken, fish, and processed meats). Non-nutrient-dense foods (NNDF) accounted for 34% of food expenditure. Younger participants (<30 years) spent more on NNDF and less on traditional meats compared with the older age groups. Participants with higher levels of formal education spent more on fruit and vegetables and less on traditional meats, when compared with participants with lower levels of formal education., Conclusions: Participants spent most household income on NNDF, a possible consequence of generation discrepancy between younger and older participants. The tendency toward NNDF, particularly among youth, should be addressed with an assessment of predictive factors and the development of targeted approaches to population-based interventions.
- Published
- 2014
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83. Assessment of dietary intake among Inuvialuit in Arctic Canada using a locally developed quantitative food frequency questionnaire.
- Author
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Kolahdooz F, Butler L, Lupu M, Sheehy T, Corriveau A, and Sharma S
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- Adult, Canada, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Northwest Territories, Nutrition Surveys, Surveys and Questionnaires, Diet, Energy Intake, Feeding Behavior, Inuit, Nutritional Status
- Abstract
Objective: Inuvialuit in Arctic Canada are experiencing a nutritional and lifestyle transition, characterized by a declining consumption of traditional foods, increased consumption of non-nutrient-dense store-bought foods (NNDF), and reduced levels of physical activity with a concurrent rise in chronic diseases. The aim of the present study was to determine dietary intake of Inuvialuit adults in the Northwest Territories, Canada, using a culturally specific, validated quantitative food frequency questionnaire (QFFQ)., Methods: A cross-sectional dietary survey of 213 randomly selected adults (≥19 years) was conducted in 3 remote communities in the Northwest Territories. Nonparametric analysis was used to compare mean nutrient intake, dietary inadequacy, and differences in nutrient density among men and women. Data were also analyzed to determine the top food groups contributing to energy and selected nutrients., Results: With response rates of 65% to 85%, 43 men (mean age 43.2 ± 12.8) and 170 women (mean age 44.7 ± 13.9) completed the QFFQ. Mean daily energy intakes for men were 3478 ± 1474 kcal and for women they were 3299 ± 1653 kcal. For both sexes, protein, carbohydrates, and fat provided approximately 16%, 47%, and 28% of energy intake, respectively. NNDFs were the top contributors to energy (39%), fat (40%), carbohydrate (54%), sugar (74%), and sodium (23%) intake. Total traditional foods from the land, sea, and sky such as polar bear and wild birds contributed 11% of energy and 41% of protein intake. Most participants' daily intakes were below recommended levels for dietary fiber; vitamins A, E, and D; potassium; and magnesium. Mean daily energy, saturated fat, and sodium intakes exceeded recommendations., Conclusions: We identified nutrient inadequacies and characterized food consumption among Inuvialuit. These data support nutritional interventions that encourage consumption of traditional foods. The cultural and ethnic differences in Canadian Arctic populations require specific tailoring of public health interventions and policy using population specific tools to meet local needs.
- Published
- 2014
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84. Dietary adequacy of vitamin D and calcium among Inuit and Inuvialuit women of child-bearing age in Arctic Canada: a growing concern.
- Author
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Kolahdooz F, Barr A, Roache C, Sheehy T, Corriveau A, and Sharma S
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- Adult, Arctic Regions, Cross-Sectional Studies, Feeding Behavior ethnology, Female, Humans, Northwest Territories, Nutrition Surveys methods, Nutrition Surveys statistics & numerical data, Nutritional Status ethnology, Surveys and Questionnaires, Young Adult, Calcium, Dietary administration & dosage, Dietary Supplements, Inuit, Vitamin D administration & dosage
- Abstract
Background: Arctic populations are at an increased risk of vitamin D inadequacy due to geographic latitude and a nutrition transition. This study aimed to assess the adequacy of dietary vitamin D and calcium among women of child-bearing age in Arctic Canada., Methods: This study collected data from 203 randomly selected women of child-bearing age (19-44 years) in Nunavut and the Northwest Territories of Arctic Canada. Cross-sectional surveys using a validated quantitative food frequency questionnaire were analysed to determine the dietary adequacy of vitamin D and calcium and summarize the top foods contributing to vitamin D and calcium intake among traditional food eaters (TFE) and non-traditional food eaters (NTFE)., Results: The response rate was between 69-93% depending on the community sampled. Mean BMIs for both TFE and NTFE were above the normal range. Traditional food eaters had a significantly higher median vitamin D intake compared with non-traditional eaters (TFE=5.13 ± 5.34 µg/day; NTFE=3.5 ± 3.22 µg/day, p=0·004). The majority of women (87%) were below the Estimated Average Requirements (EAR) for vitamin D. Despite adequate median daily calcium intake in both TFE (1,299 ± 798 mg/day) and NTFE (992 ± 704 mg/day; p=0.0005), 27% of the study population fell below the EAR for calcium. Dairy products contributed the most to intake of vitamin D (TFE=30.7%; NTFE=39.1%) and calcium (TFE=25.5%; NTFE=34.5%)., Conclusions: Inadequate dietary vitamin D intake is evident among Inuit and Inuvialuit women of child-bearing age in Arctic Canada. Promotion of nutrient-rich sources of traditional foods, supplementation protocols and/or expanded food fortification should be considered to address this nutrition concern.
- Published
- 2013
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85. Trends in energy and nutrient supply in Trinidad and Tobago from 1961 to 2007 using FAO food balance sheets.
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Sheehy T and Sharma S
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- Humans, Recommended Dietary Allowances, Trinidad and Tobago, Chronic Disease, Diet trends, Energy Intake, Food Supply, Micronutrients administration & dosage, Obesity epidemiology, Obesity etiology
- Abstract
Objective: Trinidad and Tobago has experienced an epidemiological transition over recent decades characterised by reduced rates of communicable diseases but rapidly increasing rates of obesity and non-communicable chronic diseases. The objective of the present study was to investigate the changes in energy and nutrient supply that have taken place in Trinidad and Tobago between 1961 and 2007., Design: Food balance sheets for each year between 1961 and 2007 were downloaded from the FAOSTAT database and daily per capita supply for seventeen food commodity groupings was calculated. After appropriate coding, energy and nutrient supply were determined using dietary analysis software., Setting: FAO food balance sheets for Trinidad and Tobago from 1961 to 2007., Subjects: None., Results: The food supply in 2007 provided an extra 1561 kJ (373 kcal)/capita per d than it did in 1961. Energy from carbohydrate as a percentage of total energy fell from 62% in 1961 to 57% in 2007, whereas energy from fat as a percentage of total energy increased from 26% to over 30% and now lies at the upper end of WHO recommendations. Sugars increased from 20% to over 26% of total energy and are well above WHO recommendations. When expressed on a nutrient density basis, supplies of vitamin A, folate and Ca are lower than WHO recommendations., Conclusions: Nutritional imbalances in the Trinidadian food supply need to be addressed to combat the rise in nutrition-related chronic disease that is projected to cause increased disability and premature death in the country in the coming years.
- Published
- 2013
- Full Text
- View/download PDF
86. Eating habits of a population undergoing a rapid dietary transition: portion sizes of traditional and non-traditional foods and beverages consumed by Inuit adults in Nunavut, Canada.
- Author
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Sheehy T, Roache C, and Sharma S
- Subjects
- Adult, Aged, Aged, 80 and over, Animals, Beverages, Body Height, Body Weight, Cross-Sectional Studies, Energy Intake, Female, Fishes, Fruit, Humans, Male, Meat, Middle Aged, Nunavut epidemiology, Nutritional Status, Obesity ethnology, Obesity prevention & control, Population Groups, Socioeconomic Factors, Surveys and Questionnaires, Vegetables, Young Adult, Feeding Behavior ethnology, Inuit, Portion Size
- Abstract
Background: To determine the portion sizes of traditional and non-traditional foods being consumed by Inuit adults in three remote communities in Nunavut, Canada., Methods: A cross-sectional study was carried out between June and October, 2008. Trained field workers collected dietary data using a culturally appropriate, validated quantitative food frequency questionnaire (QFFQ) developed specifically for the study population., Results: Caribou, muktuk (whale blubber and skin) and Arctic char (salmon family), were the most commonly consumed traditional foods; mean portion sizes for traditional foods ranged from 10 g for fermented seal fat to 424 g for fried caribou. Fried bannock and white bread were consumed by >85% of participants; mean portion sizes for these foods were 189 g and 70 g, respectively. Sugar-sweetened beverages and energy-dense, nutrient-poor foods were also widely consumed. Mean portion sizes for regular pop and sweetened juices with added sugar were 663 g and 572 g, respectively. Mean portion sizes for potato chips, pilot biscuits, cakes, chocolate and cookies were 59 g, 59 g, 106 g, 59 g, and 46 g, respectively., Conclusions: The present study provides further evidence of the nutrition transition that is occurring among Inuit in the Canadian Arctic. It also highlights a number of foods and beverages that could be targeted in future nutritional intervention programs aimed at obesity and diet-related chronic disease prevention in these and other Inuit communities.
- Published
- 2013
- Full Text
- View/download PDF
87. Ethnic differences in grains consumption and their contribution to intake of B-vitamins: results of the Multiethnic Cohort Study.
- Author
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Sharma S, Sheehy T, and Kolonel LN
- Subjects
- Aged, Body Mass Index, Cohort Studies, Cross-Sectional Studies, Energy Intake, Female, Folic Acid administration & dosage, Hawaii, Humans, Los Angeles, Male, Middle Aged, Niacin administration & dosage, Riboflavin administration & dosage, Surveys and Questionnaires, Thiamine administration & dosage, Vitamin B 6 administration & dosage, Edible Grain chemistry, Ethnicity statistics & numerical data, Feeding Behavior, Vitamin B Complex administration & dosage
- Abstract
Background: Research indicates that a diet rich in whole grains may reduce the risk of prevalent chronic diseases, including cardiovascular disease, diabetes, and some cancers, and that risk for these diseases varies by ethnicity. The objective of the current study was to identify major dietary sources of grains and describe their contribution to B vitamins in five ethnic groups., Methods: A cross-sectional mail survey was used to collect data from participants in the Multiethnic Cohort Study in Hawaii and Los Angeles County, United States, from 1993 to 1996. Dietary intake data collected using a quantitative food frequency questionnaire was available for 186,916 participants representing five ethnic groups (African American, Latino, Japanese American, Native Hawaiian and Caucasian) aged 45-75 years. The top sources of grain foods were determined, and their contribution to thiamin, riboflavin, niacin, vitamin B6, and folic acid intakes were analyzed., Results: The top source of whole grains was whole wheat/rye bread for all ethnic-sex groups, followed by popcorn and cooked cereals, except for Native Hawaiian men and Japanese Americans, for whom brown/wild rice was the second top source; major contributors of refined grains were white rice and white bread, except for Latinos. Refined grain foods contributed more to grain consumption (27.1-55.6%) than whole grain foods (7.4-30.8%) among all ethnic-sex groups, except African American women. Grain foods made an important contribution to the intakes of thiamin (30.2-45.9%), riboflavin (23.1-29.2%), niacin (27.1-35.8%), vitamin B6 (22.9-27.5%), and folic acid (23.3-27.7%)., Conclusions: This is the first study to document consumption of different grain sources and their contribution to B vitamins in five ethnic groups in the U.S. Findings can be used to assess unhealthful food choices, to guide dietary recommendations, and to help reduce risk of chronic diseases in these populations.
- Published
- 2013
- Full Text
- View/download PDF
88. Smoking and dietary inadequacy among Inuvialuit women of child bearing age in the Northwest Territories, Canada.
- Author
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Kolahdooz F, Mathe N, Katunga LA, Beck L, Sheehy T, Corriveau A, and Sharma S
- Subjects
- Adult, Ascorbic Acid administration & dosage, Body Mass Index, Canada, Cross-Sectional Studies, Dietary Fiber administration & dosage, Female, Humans, Iron, Dietary administration & dosage, Life Style, Logistic Models, Malnutrition epidemiology, Motor Activity, Northwest Territories epidemiology, Potassium, Dietary administration & dosage, Risk Factors, Smoking adverse effects, Smoking epidemiology, Surveys and Questionnaires, Vitamin D administration & dosage, Vitamin E administration & dosage, Young Adult, Zinc administration & dosage, Feeding Behavior ethnology, Inuit statistics & numerical data, Malnutrition ethnology, Smoking ethnology
- Abstract
Objective: The prevalence of smoking in Aboriginal Canadians is higher than non-Aboriginal Canadians, a behavior that also tends to alter dietary patterns. Compared with the general Canadian population, maternal smoking rates are almost twice as high. The aim of this study was to compare dietary adequacy of Inuvialuit women of childbearing age comparing smokers versus non-smokers., Research Methods & Procedures: A cross-sectional study, where participants completed a culturally specific quantitative food frequency questionnaire. Non-parametric analysis was used to compare mean nutrient intake, dietary inadequacy and differences in nutrient density among smokers and non-smokers. Multiple logistic regression analyses were performed for key nutrients inadequacy and smoking status. Data was collected from three communities in the Beaufort Delta region of the Northwest Territories, Canada from randomly selected Inuvialuit women of childbearing age (19-44 years)., Results: Of 92 participants, 75% reported being smokers. There were no significant differences in age, BMI, marital status, education, number of people in household working and/or number of self employed, and physical activity between smokers and non-smokers. Non-parametric analysis showed no differences in nutrient intake between smokers and non-smokers. Logistic regression however revealed there was a positive association between smoking and inadequacies of vitamin C (OR = 2.91, 95% CI, 1.17-5.25), iron (OR = 3.16, 95% CI, 1.27-5.90), and zinc (OR = 2.78, 95% CI, 1.12-4.94). A high percentage of women (>60%), regardless of smoking status, did not meet the dietary recommendations for fiber, vitamin D, E and potassium., Conclusions: This study provides evidence of inadequate dietary intake among Inuvialuit of childbearing age regardless of smoking behavior.
- Published
- 2013
- Full Text
- View/download PDF
89. Frequency of consumption of foods and beverages by Inuvialuit adults in Northwest Territories, Arctic Canada.
- Author
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Zotor F, Sheehy T, Lupu M, Kolahdooz F, Corriveau A, and Sharma S
- Subjects
- Adult, Arctic Regions epidemiology, Body Mass Index, Cross-Sectional Studies, Female, Health Transition, Humans, Male, Middle Aged, Northwest Territories epidemiology, Nutrition Surveys, Obesity epidemiology, Obesity etiology, Overweight epidemiology, Overweight etiology, Prevalence, Beverages adverse effects, Diet adverse effects, Diet ethnology, Feeding Behavior ethnology, Food Quality, Inuit, Rural Health ethnology
- Abstract
Limited data exist regarding nutrient intakes and overall dietary quality in Canadian Arctic populations. This cross-sectional study determined the frequency of consumption of traditional meats (e.g. caribou, polar bear, seal, char and whale) and non-traditional store-bought foods including non-traditional meats (e.g. beef, pork and chicken), grains, dairy, fruits, vegetables and non-nutrient dense foods (NNDFs) (e.g. butter, chocolate, chips, candy and pop) by Inuvialuit adults (175 women, mean age 44 ± 14 years; 55 men, mean age 41 ± 13 years) in three remote communities in the Northwest Territories. Using a validated quantitative food frequency questionnaire, frequency of consumption over a 30-day period was determined for 141 commonly reported foods. Mean consumption of traditional meats (1.6 times/day), fruits (1 time/day) and vegetables (0.6 times/day) was less frequent than that of NNDFs (5.0 times/day). Nutritional intervention strategies are needed to promote more frequent consumption of nutrient-rich foods and less frequent consumption of NNDFs in these Arctic communities.
- Published
- 2012
- Full Text
- View/download PDF
90. The nutrition transition in the Republic of Ireland: trends in energy and nutrient supply from 1961 to 2007 using Food and Agriculture Organization food balance sheets.
- Author
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Sheehy T and Sharma S
- Subjects
- Humans, Ireland, Nutrition Surveys, Retrospective Studies, Socioeconomic Factors, Time Factors, Diet, Dietary Carbohydrates, Dietary Fats, Dietary Proteins, Energy Intake, Feeding Behavior
- Abstract
Over the course of the last 50 years the Republic of Ireland has gone from being one of the poorest countries in Europe to one of the richest; however, it is now experiencing increasing rates of obesity and non-communicable chronic disease. Although several national nutrition surveys have been carried out in Ireland since 1990, there is little information on the Irish diet before then. We analysed the FAO food balance sheets for Ireland from 1961 to 2007 in order to characterise the changes in energy and nutrient supply that took place during that period. Food balance sheets were downloaded from the FAOSTAT database and per capita supply of commodities was analysed using dietary analysis software. Energy from carbohydrate as a percentage of total energy fell from 55 % in 1961 to 46 % in 2007, whereas energy from fat increased from 29 % to 34 %; these values are well outside WHO recommendations for the prevention of chronic disease. Energy from alcohol as a percentage of total energy has doubled within the last 20 years. On a nutrient-density basis, vitamins and minerals met or exceeded WHO recommendations, apart from vitamin D, folate, Ca and Fe. Although there are methodological limitations associated with the use of food balance sheets, the present results demonstrate that the current imbalances in the Irish diet were already evident several decades ago. Because they are so long established, they will be difficult to reverse unless major public health nutrition interventions are implemented.
- Published
- 2011
- Full Text
- View/download PDF
91. Vitamin D deficiency and disease risk among aboriginal Arctic populations.
- Author
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Sharma S, Barr AB, Macdonald HM, Sheehy T, Novotny R, and Corriveau A
- Subjects
- American Indian or Alaska Native, Arctic Regions epidemiology, Bone Diseases etiology, Diabetes Mellitus etiology, Energy Intake, Ethnicity, Humans, Neoplasms etiology, Prevalence, Risk Factors, Sunlight, Vitamin D Deficiency complications, Diet, Vitamin D administration & dosage, Vitamin D Deficiency epidemiology, Vitamins administration & dosage
- Abstract
Aboriginal populations living above the Arctic Circle are at particularly high risk of vitamin D deficiency due to limited ultraviolet B exposure (related to geographic latitude) and inadequate dietary intake (recently related to decreased traditional food consumption). Major changes in diet and lifestyle over the past 50 years in these populations have coincided with increased prevalence rates of rickets, cancer, diabetes, and obesity, each of which may be associated with vitamin D inadequacy. This review examines the risk factors for vitamin D inadequacy, the associations between vitamin D and disease risk at high geographic latitudes, and the recommendations for improving vitamin D status particularly among aboriginal Arctic populations. Traditional foods, such as fatty fish and marine mammals, are rich sources of vitamin D and should continue to be promoted to improve dietary vitamin D intake. Supplementation protocols may also be necessary to ensure adequate vitamin D status in the Arctic., (© 2011 International Life Sciences Institute.)
- Published
- 2011
- Full Text
- View/download PDF
92. The changing face of orthostatic and neurocardiogenic syncope with age.
- Author
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Cooke J, Carew S, Costelloe A, Sheehy T, Quinn C, and Lyons D
- Subjects
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Child, Cost of Illness, Female, Humans, Hypotension, Orthostatic complications, Hypotension, Orthostatic diagnosis, Male, Middle Aged, Prevalence, Retrospective Studies, Syncope, Vasovagal diagnosis, Syncope, Vasovagal etiology, Tilt-Table Test, Young Adult, Aging pathology, Hypotension, Orthostatic epidemiology, Posture physiology, Syncope, Vasovagal epidemiology
- Abstract
Aim: Reports of the outcomes of syncope assessment across a broad spectrum of ages in a single population are scarce. It is our objective to chart the varying prevalence of orthostatic and neurocardiogenic syncope (NCS) as a patient ages., Methods: This was a retrospective study. All consecutive patients referred to a tertiary referral syncope unit over a decade were included. Patients were referred with recurrent falls or orthostatic intolerance. Tilt tests and carotid sinus massage (CSM) were performed in accordance with best practice guidelines., Results: A total of 3002 patients were included (1451 short tilt, 127 active stand, 1042 CSM and 382 prolonged tilt). Ages ranged from 11 to 91 years with a median (IQR) of 75 (62-81) years. There were 1914 females; 1088 males. Orthostatic hypotension (OH) was the most commonly observed abnormality (test positivity of 60.3%). Those with OH had a median (IQR) age of 78 (71-83) years. Symptomatic patients were significantly younger than asymptomatic (P = 0.03). NCS demonstrated a bimodal age distribution. Of 194 patients with carotid sinus hypersensitivity, the median age (IQR) was 77 (68-82) years. Those with vasovagal syncope (n = 80) had a median (IQR) age of 30 (19-44) years. There were 57 patients with isolated postural orthostatic tachycardia syndrome. Of the total patients, 75% were female. They had a median (IQR) age of 23 (17-29) years., Conclusion: We have confirmed, in a single population, a changing pattern in the aetiology of syncope as a person ages. The burden of disease is greatest in the elderly.
- Published
- 2011
- Full Text
- View/download PDF
93. Use of FAO food balance sheets to estimate the potential ability of novel folate-enriched eggs to increase the folate supply in European Union countries.
- Author
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Sheehy T and Sharma S
- Subjects
- Animal Feed analysis, Animals, Chickens, Databases, Factual, Europe, European Union, Food Handling, Guidelines as Topic, Neural Tube Defects prevention & control, Nutritional Requirements, Eggs analysis, Folic Acid analysis, Food, Fortified analysis, United Nations organization & administration
- Abstract
Objective: European governments have yet to introduce mandatory folic acid fortification of foods for neural tube defect prevention because of uncertainty about the long-term safety of high intake of folic acid. Novel folate-enriched eggs have been proposed as offering a practical way of increasing intake of natural folates, which do not have the same safety concerns as synthetic folic acid. Our objective was to estimate the potential increase in folate supply that could occur in European Union (EU) countries if normal eggs were replaced by folate-enriched eggs., Design: FAOSTAT data on daily per capita availability of eggs were linked to mean folate concentrations of un-enriched and folate-enriched eggs from three representative feeding trials from the recent literature., Setting: Data were collated in Microsoft Excel., Subjects: The study used food balance sheets for Europe for 1961-2003 and for twenty-six individual EU countries for 2003., Results: There has been little variation in egg supply in Europe over the past 40 years, with eggs providing only about 1·3-1·6 % of total energy. In 2003, the average per capita egg supply across twenty-six EU countries was 32·8 g/d, equivalent to a little over half an egg. Even if the folate concentrations of all eggs across the EU were increased two- to threefold, per capita folate supply would increase only by about 25 μg/d., Conclusions: At current enrichment levels, the availability of novel folate-enriched eggs will have little impact on folate supply in EU countries. In the absence of mandatory fortification, additional natural folate sources are needed urgently.
- Published
- 2011
- Full Text
- View/download PDF
94. Near death and neurocardiogenic syncope.
- Author
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Donnelly T, Carew S, Sheehy T, Costelloe A, Fahey G, and Lyons D
- Subjects
- Adolescent, Defibrillators, Implantable, Electrocardiography, Female, Humans, Syncope, Vasovagal diagnosis, Ventricular Fibrillation diagnosis, Ventricular Fibrillation therapy, Critical Illness, Heart Arrest etiology, Syncope, Vasovagal complications, Ventricular Fibrillation etiology
- Abstract
We report the case of an 18-year-old female who presented as an out-of-hospital ventricular fibrillation cardiac arrest. She required ICD insertion and recovered without deficit. Following recurrent syncopal episodes we diagnosed the co-existence of Neurocardiogenic syncope.
- Published
- 2007
- Full Text
- View/download PDF
95. Treatment of vasodepressor carotid sinus syndrome with midodrine: a randomized, controlled pilot study.
- Author
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Moore A, Watts M, Sheehy T, Hartnett A, Clinch D, and Lyons D
- Subjects
- Accidental Falls prevention & control, Aged, Aged, 80 and over, Blood Pressure, Cross-Over Studies, Double-Blind Method, Female, Heart Rate, Humans, Male, Midodrine pharmacology, Photoplethysmography, Placebos, Prospective Studies, Treatment Outcome, Vasoconstrictor Agents pharmacology, Midodrine therapeutic use, Syncope drug therapy, Vasoconstrictor Agents therapeutic use
- Abstract
Objectives: To evaluate the efficacy of treatment of the vasodepressor form of carotid sinus hypersensitivity (carotid sinus syndrome (CSS)) with midodrine., Design: A prospective, double-blind, randomized, controlled trial of crossover design., Setting: A dedicated outpatient facility with access to tilt-table, digital arterial photoplethysmography, and 24-hour ambulatory blood pressure (BP) monitoring equipment., Participants: Ten older adults (4 male, 6 female, mean age 75, range 66-86 years) with a history of unexplained syncope who displayed an asymptomatic decrease in systolic BP (SBP) of more than 50 mmHg or a symptomatic decrease of more than 30 mmHg within 30 seconds of carotid sinus massage (CSM)., Measurements: Symptom reproduction and BP and heart rate changes were evaluated after CSM in supine and semierect positions on the right and then left sides. These measurements were performed on the final day of placebo and active-treatment phases. Ambulatory 24-hour BP monitoring took place on the penultimate and final days of each treatment phase., Results: Eight patients were symptomatic after their initial CSM. The mean+/-standard deviation SBP decrease after initial CSM was 54+/-22 mmHg. Initial mean 24-hour ambulatory BP was 127/70+/-7/5 mmHg. Eight patients reported symptoms after CSM at the end of the placebo phase. The mean SBP decrease at the end of the placebo phase was 49+/-12 mmHg. The mean 24-hour ambulatory BP was 127/69+/-9/7 mmHg. One patient reported symptoms after CSM at the end of the active-treatment phase. The mean SBP decrease at the end of the active-treatment phase was 36+/-9 mmHg. The mean 24-hour ambulatory BP at the end of the treatment phase was 133/75+/-7/6 mmHg. The differences in symptom reporting and mean SBP decrease after CSM were both significant (P<.01 and P=.03, respectively)., Conclusion: The results of this pilot study suggest that treatment of vasodepressor CSS with midodrine significantly reduced the rate of symptom reporting and attenuated SBP decreases after CSM but increased mean 24-hour ambulatory BP.
- Published
- 2005
- Full Text
- View/download PDF
96. J. Marion Sims and Nathan Bozeman: the fight for priority in the surgical repair of vesico-vaginal fistula.
- Author
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Howard PS and Sheehy TW
- Subjects
- Alabama, Female, General Surgery history, History, 19th Century, Humans, Vesicovaginal Fistula surgery, Vesicovaginal Fistula history
- Published
- 1996
97. Case report: factitious hypoglycemia in diabetic patients.
- Author
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Sheehy TW
- Subjects
- Adolescent, Blood Glucose metabolism, C-Peptide blood, Child, Factitious Disorders blood, Humans, Hypoglycemia blood, Insulin therapeutic use, Male, Diabetes Mellitus, Type 1 blood, Diabetes Mellitus, Type 1 drug therapy, Factitious Disorders chemically induced, Hypoglycemia chemically induced, Insulin adverse effects
- Abstract
Factitious hypoglycemia (FH) in a diabetic patient represents a difficult diagnostic and costly management problem. An adolescent diabetic with FH is reported. A literature search revealed 10 adolescent and 45 adult diabetic patients with FH. Tests currently available for diagnosis are evaluated. The role of psychiatric therapy in relation to overall management and prognosis is stressed.
- Published
- 1992
- Full Text
- View/download PDF
98. Alcohol: yesterday and today have we changed?
- Author
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Allison S and Sheehy TW
- Subjects
- Alcohol Drinking, Alcoholic Beverages history, Female, History, 18th Century, History, 19th Century, History, 20th Century, Humans, Male, United States, Alcoholism psychology
- Published
- 1992
99. Alcohol and the heart. How it helps, how it harms.
- Author
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Sheehy TW
- Subjects
- Cardiomyopathy, Alcoholic, Coronary Circulation drug effects, Coronary Disease chemically induced, Coronary Disease prevention & control, Ethanol adverse effects, Humans, Vasodilation drug effects, Ethanol pharmacology, Heart drug effects
- Abstract
Does regular consumption of alcohol protect against coronary artery disease but not against sudden death? In this article, Dr Sheehy examines several theories that have been proposed to explain the cardioprotective effect of ethanol and also reviews the factors related to sudden death in alcoholics.
- Published
- 1992
- Full Text
- View/download PDF
100. Diabetic gustatory sweating.
- Author
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Sheehy TW
- Subjects
- Adult, Humans, Male, Diabetic Neuropathies complications, Sweating, Gustatory etiology
- Abstract
Gustatory sweating is an unusual entity that may occur as an idiosyncratic reaction to certain foods, as a localized reaction to trauma or infection, or as the result of diabetic neuropathy. This report deals with a severe case of diabetic gustatory sweating, discusses the various types of gustatory sweating, and reviews the English literature dealing with the diabetic form.
- Published
- 1991
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