51. Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates
- Author
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Shen, Xiaoying, Duffy, Ryan, Howington, Robert, Cope, Alethea, Sadagopal, Shanmugalakshmi, Park, Haesun, Pal, Ranajit, Kwa, Suefen, Ding, Song, Yang, Otto O, Fouda, Genevieve G, Le Grand, Roger, Bolton, Diane, Esteban, Mariano, Phogat, Sanjay, Roederer, Mario, Amara, Rama R, Picker, Louis J, Seder, Robert A, McElrath, M Juliana, Barnett, Susan, Permar, Sallie R, Shattock, Robin, DeVico, Anthony L, Felber, Barbara K, Pavlakis, George N, Pantaleo, Giuseppe, Korber, Bette T, Montefiori, David C, and Tomaras, Georgia D
- Subjects
Medical Microbiology ,Biomedical and Clinical Sciences ,Immunology ,Vaccine Related ,Vaccine Related (AIDS) ,Prevention ,Biotechnology ,Infectious Diseases ,HIV/AIDS ,Immunization ,3.4 Vaccines ,Prevention of disease and conditions ,and promotion of well-being ,Infection ,Good Health and Well Being ,Animals ,Antibodies ,Viral ,Antibody Specificity ,Epitopes ,HIV-1 ,Immunoglobulin G ,Microarray Analysis ,Primates ,Simian Immunodeficiency Virus ,Species Specificity ,Viral Envelope Proteins ,Simian immunodeficiency virus ,Biological Sciences ,Agricultural and Veterinary Sciences ,Medical and Health Sciences ,Virology ,Agricultural ,veterinary and food sciences ,Biological sciences ,Biomedical and clinical sciences - Abstract
To evaluate antibody specificities induced by simian immunodeficiency virus (SIV) versus human immunodeficiency virus type 1 (HIV-1) envelope antigens in nonhuman primate (NHP), we profiled binding antibody responses to linear epitopes in NHP studies with HIV-1 or SIV immunogens. We found that, overall, HIV-1 Env IgG responses were dominated by V3, with the notable exception of the responses to the vaccine strain A244 Env that were dominated by V2, whereas the anti-SIVmac239 Env responses were dominated by V2 regardless of the vaccine regimen.
- Published
- 2015