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This study investigates the derivation of scalar implicatures in Chinese children with reading difficulties (RD). Twenty-four children with RD (mean age 9 years and 8 months), 20 age-matched typical readers (mean age 9 years and 10 months), 20 six-year-old children and 20 five-year-old children were tested with the comprehension of sentences with scalar items "yixie" 'some' and "suoyou" 'all'. The pattern of children with RD was similar to that of six-year-old children but differed from that of age-matched typical readers in the comprehension of the sentences containing "yixie" that were pragmatically "underinformative" in the context. Interestingly, many children with RD and younger children, who accepted the sentences containing "yixie" that were pragmatically "underinformative," rejected the sentences containing "yixie" that were true in a context supporting the literal (semantic) interpretation. These results support the view that the computation of scalar implicatures may be impaired in children with RD, due to a complex interplay of factors such as (at least) the lexical knowledge of the scalar term and processing/pragmatic limitations.

DFT functionals are of paramount importance for an accurate electronic and structural description of transition metal systems. In this work, a systematic analysis using some well‐known and commonly used DFT functionals is performed. A comparison of the structural and energetic parameters calculated with the available experimental data is made in order to find the adequate functional for an accurate description of the TiO2 bulk and surface of both anatase and rutile structures. In the absence of experimental data on the surface energy, the theoretical predictions obtained using the high‐accuracy HSE06 functional were used as a reference to compare against the surface energy values calculated with the other DFT functionals. A clear improvement in the electronic description of both anatase and rutile was observed by introducing the Hubbard U correction term to PBE, PW91, and OptPBE functionals. The OptPBE‐U4 functional was found to offer a good compromise between accurately describing the structural and electronic properties of titania. [ABSTRACT FROM AUTHOR]

There is a debate as to whether topic structures in Chinese involve A'-movement or result from base-generation of the topic in the left periphery. If Chinese topicalization was derived by movement, under the assumptions of Friedmann et al.'s Relativized Minimality (Lingua 119:67-88, 2009), we would expect children's comprehension of object topicalization (with OSV order) to be worse than their comprehension of subject topicalization (with SVO order). This study examined 146 Mandarin-speaking children from age three to age six by means of a picture-sentence matching task with an appropriate context. The results showed a subject/object asymmetry when the topic marker is overt, and no asymmetry when the topic marker is covert. This suggests that the presence or absence of topic markers play an important role in children's comprehension of topicalization. We propose that both structures involve movement in the adult grammar, but not in the child grammar, at least initially. Sentences without overt topic markers are base-generated on a par with gapless sentences with a topic, and the base-generation analysis is abandoned as soon as children learn the syntax and semantics of topic markers, which function as attractors of topics.

Recent experimental results suggest that negation is particularly challenging for children with reading difficulties. This study looks at how young poor readers, speakers of Mandarin Chinese, comprehend affirmative and negative sentences as compared with a group of age-matched typical readers. Forty-four Chinese children were tested with a truth value judgment task. The results reveal that negative sentences were harder to process than affirmative ones, irrespective of the distinction between poor and typical readers. Moreover, poor readers performed worse than typical readers in comprehending sentences, regardless of whether they were affirmative or negative sentences. We interpret the results as (a) confirming the two-step simulation hypothesis, based on the result that the difficulty in processing negation has a general validity (persisting in pragmatically felicitous contexts), and (b) disconfirming that negation, as far as behavioral data are concerned, can be used as a reliable linguistic predictor of reading difficulties.

Author(s): Neeta Shenai [sup.1] [sup.2] , Priya Gopalan [sup.1] [sup.2] , Jody Glance [sup.1] [sup.3] Author Affiliations: (Aff1) 0000 0001 0650 7433, grid.412689.0, Western Psychiatric Institute and Clinic, University of [...], Purpose To evaluate the efficacy of a brief education session affecting patient perspectives on follow up care of substance use and trauma treatment in pregnant women admitted to a medical hospital. Description Participants (N = 31) were recruited from the antepartum unit at Magee-Women's Hospital at the University of Pittsburgh who had current substance use and history of trauma. A voluntary individual educational session was offered that discussed the diagnosis and treatment of substance use and trauma, fundamental coping skills, and local resources. Utility of the session, knowledge of PTSD, and barriers of care were evaluated through a pre- and post- session questionnaire. Assessment All participants found the session improved their knowledge of PTSD, substance use, safe coping skills, and increased their likelihood of pursuing further follow up treatment. Conclusion Brief educational interventions that are integrated in the medical hospital are found to be useful by patients and reported to influence their decision to seek further treatment. Further studies are needed to analyze the long-term outcomes of brief interventions.

Pulmonary tuberculosis (PTB) is characterized by lung granulomas, inflammation and tissue destruction. Here we used within-subject peripheral blood gene expression over time to correlate with the within-subject lung metabolic activity, as measured by positron emission tomography (PET) to identify biological processes and pathways underlying overall resolution of lung inflammation. We used next-generation RNA sequencing and [18F]FDG PET-CT data, collected at diagnosis, week 4, and week 24, from 75 successfully cured PTB patients, with the [18F]FDG activity as a surrogate for lung inflammation. Our linear mixed-effects models required that for each individual the slope of the line of [18F]FDG data in the outcome and the slope of the peripheral blood transcript expression data correlate, i.e., the slopes of the outcome and explanatory variables had to be similar. Of 10,295 genes that changed as a function of time, we identified 639 genes whose expression profiles correlated with decreasing [18F]FDG uptake levels in the lungs. Gene enrichment over-representation analysis revealed that numerous biological processes were significantly enriched in the 639 genes, including several well known in TB transcriptomics such as platelet degranulation and response to interferon gamma, thus validating our novel approach. Others not previously associated with TB pathobiology included smooth muscle contraction, a set of pathways related to mitochondrial function and cell death, as well as a set of pathways connecting transcription, translation and vesicle formation. We observed up-regulation in genes associated with B cells, and down-regulation in genes associated with platelet activation. We found 254 transcription factor binding sites to be enriched among the 639 gene promoters. In conclusion, we demonstrated that of the 10,295 gene expression changes in peripheral blood, only a subset of 639 genes correlated with inflammation in the lungs, and the enriched pathways provide a description of the biology of resolution of lung inflammation as detectable in peripheral blood. Surprisingly, resolution of PTB inflammation is positively correlated with smooth muscle contraction and, extending our previous observation on mitochondrial genes, shows the presence of mitochondrial stress. We focused on pathway analysis which can enable therapeutic target discovery and potential modulation of the host response to TB.

The acquisition of languages by children using two languages is a matter of debate as many factors contribute to the success of this type of acquisition. We focus on how the competence of dual-language children changes in their two languages as a function of length of exposure and establish whether there are reciprocal influences during language development. We examined the comprehension of subject and object relative clauses in a group of 6-year-old (younger) and 8-year-old (older) Mandarin–Italian dual-language children. After 3 years of regular and intensive exposure to Italian, the younger group reached the same level of competence in the comprehension of relative clauses in their two languages, and after 5 years of exposure to Italian, the older group had a better comprehension of relative clauses in Italian than in Mandarin. Acquiring two languages leads to bidirectional influence, beyond a reciprocal support. Finally, some penalty may be observed in the acquisition of subject head-final relative clauses, which is not evident in that of subject head-initial relative clauses.