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57,001 results on '"Shepard A"'

52. Phase 1 dose expansion and biomarker study assessing first-in-class tumor microenvironment modulator VT1021 in patients with advanced solid tumors

Author

Chen, Jian Jenny, Vincent, Melanie Y., Shepard, Dale, Peereboom, David, Mahalingam, Devalingam, Battiste, James, Patel, Manish R., Juric, Dejan, Wen, Patrick Y., Bullock, Andrea, Selfridge, Jennifer Eva, Pant, Shubham, Liu, Joyce, Li, Wendy, Fyfe, Susanne, Wang, Suming, Zota, Victor, Mahoney, James, Watnick, Randolph S., Cieslewicz, Michael, and Watnick, Jing

Published
2024
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63. Electronic Excitation Response of DNA to High-energy Proton Radiation in Water

Author

Shepard, Christopher, Yost, Dillon, and Kanai, Yosuke

Subjects
Condensed Matter - Soft Condensed Matter, Physics - Chemical Physics
Abstract

The lack of molecular-level understanding for the electronic excitation response of DNA to charged particle radiation, such as high-energy protons, remains a fundamental scientific bottleneck in advancing proton and other ion beam cancer therapies. In particular, the dependence of different types of DNA damage on high-energy protons represents a significant knowledge void. Here we employ first-principles real-time time-dependent density functional theory simulation, using a massively-parallel supercomputer, to unravel the quantum-mechanical details of the energy transfer from high-energy protons to DNA in water. The calculations reveal that protons deposit significantly more energy onto the DNA sugar-phosphate side chains than onto the nucleobases, and greater energy transfer is expected onto the DNA side chains than onto water. As a result of this electronic stopping process, highly energetic holes are generated on the DNA side chains as a source of oxidative damage., Comment: Main text (9 pages) with 4 figures and Supplemental Information

Published
2023
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64. Radiation-Induced Cognitive Decline: Challenges and Solutions

Author

Shamsesfandabadi P, Patel A, Liang Y, Shepard MJ, and Wegner RE

Subjects
radiation therapy, radiation-induced cognitive decline, ricd, cognitive decline, cognitive function, central nervous system cancers, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Parisa Shamsesfandabadi,1 Arpeet Patel,2 Yun Liang,1 Matthew J Shepard,3 Rodney E Wegner1 1Radiation Oncology department, Allegheny Health Network, Pittsburgh, PA, USA; 2Drexel University College of Medicine, Philadelphia, PA, USA; 3Neurosurgery Department, Allegheny Health Network, Pittsburgh, PA, USACorrespondence: Parisa Shamsesfandabadi, Email parisa.shamsesfandabadi@ahn.orgAbstract: Radiation therapy, a common treatment for central nervous system cancers, can negatively impact cognitive function, resulting in radiation-induced cognitive decline (RICD). RICD involves a decline in cognitive abilities such as memory and attention, likely due to damage to brain white matter, inflammation, and oxidative stress. The multifactorial nature of RICD poses challenges including different mechanisms of injury (neurogenesis, oxidative stress and neuroinflammation, dendritic structure alterations and vascular effects) and confounding factors like advanced age, and pre-existing conditions. Despite these challenges, several potential solutions exist. Neuroprotective agents like antioxidants can mitigate radiation damage, while cognitive rehabilitation techniques such as cognitive training and memory strategies improve cognitive function. Advanced imaging techniques like magnetic resonance imaging (MRI) help identify vulnerable brain areas, and proton therapy offers precise targeting of cancer cells, sparing healthy tissue. Multidisciplinary care teams are crucial for managing RICD’s cognitive and psychological effects. Personalized medicine, using genetic and molecular data, can identify high-risk patients and tailor treatments accordingly. Emerging therapies, including stem cell therapy and regenerative medicine, offer hope for repairing or replacing damaged brain tissue. Addressing RICD is vital for cancer survivors, necessitating consideration of cognitive function and provision of appropriate support and resources for those experiencing cognitive decline.Keywords: radiation therapy, radiation-induced cognitive decline, RICD, cognitive decline, cognitive function, central nervous system cancers

Published
2024

66. Relational Equity: Adapting an Elementary Mathematics Teaching Methods Course to Online Contexts

Author

Ruef, Jennifer L. and Shepard, Reid

Abstract

Background. This article describes the redesign, implementation, and students' experiences with an elementary mathematics teaching methods course in the Pacific Northwest of the United States that was forced online due to COVID-19 restrictions. We share course design principles, changes to reflect online teaching, and students' experiences of relational equity, "the care and consideration students and teachers must take with each other to establish and maintain a culture of equitable learning." Methods: This study took place online. 50 out of a cohort of 54 pre-service elementary teacher candidates participated. Our methods included analysis of course documents, analytic memoing, and analysis of students' responses to online open response surveys. We qualitatively analyzed the responses from the surveys, coding for a priori and emergent themes (Charmaz, 1995; Emerson et al., 2011; Miles et al., 2019). Findings: The results share the ways the instructors modified the course for online instruction and indicate that our participants experienced successes or challenges to enacting relational equity in the following: (i) curriculum and assessments, (ii) instructors, (iii) generic reference to the course, (iv) technology limits, and (v) future teaching. Contribution: This work sheds light on how two mathematics teacher educators redesigned their course for online instruction while centering and modeling relational equity teaching practices.

Published
2022

67. Open data from the third observing run of LIGO, Virgo, KAGRA and GEO

Author

The LIGO Scientific Collaboration, the Virgo Collaboration, the KAGRA Collaboration, Abbott, R., Abe, H., Acernese, F., Ackley, K., Adhicary, S., Adhikari, N., Adhikari, R. X., Adkins, V. K., Adya, V. B., Affeldt, C., Agarwal, D., Agathos, M., Aguiar, O. D., Aiello, L., Ain, A., Ajith, P., Akutsu, T., Albanesi, S., Alfaidi, R. A., Al-Jodah, A., Alléné, C., Allocca, A., Almualla, M., Altin, P. A., Amato, A., Amez-Droz, L., Amorosi, A., Anand, S., Ananyeva, A., Andersen, R., Anderson, S. B., Anderson, W. G., Andia, M., Ando, M., Andrade, T., Andres, N., Andrés-Carcasona, M., Andrić, T., Ansoldi, S., Antelis, J. M., Antier, S., Aoumi, M., Apostolatos, T., Appavuravther, E. Z., Appert, S., Apple, S. K., Arai, K., Araya, A., Araya, M. C., Areeda, J. S., Arène, M., Aritomi, N., Arnaud, N., Arogeti, M., Aronson, S. M., Arun, K. G., Asada, H., Ashton, G., Aso, Y., Assiduo, M., Melo, S. Assis de Souza, Aston, S. M., Astone, P., Aubin, F., AultONeal, K., Babak, S., Badalyan, A., Badaracco, F., Badger, C., Bae, S., Bagnasco, S., Bai, Y., Baier, J. G., Baiotti, L., Baird, J., Bajpai, R., Baka, T., Ball, M., Ballardin, G., Ballmer, S. W., Baltus, G., Banagiri, S., Banerjee, B., Bankar, D., Baral, P., Barayoga, J. C., Barber, J., Barish, B. C., Barker, D., Barneo, P., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Barthelmy, S. D., Barton, M. A., Bartos, I., Basak, S., Basalaev, A., Bassiri, R., Basti, A., Bawaj, M., Bayley, J. C., Baylor, A. C., Bazzan, M., Bécsy, B., Bedakihale, V. M., Beirnaert, F., Bejger, M., Bell, A. S., Benedetto, V., Beniwal, D., Benoit, W., Bentley, J. D., Yaala, M. Ben, Bera, S., Berbel, M., Bergamin, F., Berger, B. K., Bernuzzi, S., Beroiz, M., Berry, C. P. L., Bersanetti, D., Bertolini, A., Betzwieser, J., Beveridge, D., Bevins, N., Bhandare, R., Bhandari, A. V., Bhardwaj, U., Bhatt, R., Bhattacharjee, D., Bhaumik, S., Bianchi, A., Bilenko, I. A., Bilicki, M., Billingsley, G., Bini, S., Birnholtz, O., Biscans, S., Bischi, M., Biscoveanu, S., Bisht, A., Biswas, B., Bitossi, M., Bizouard, M. -A., Blackburn, J. K., Blair, C. D., Blair, D. G., Blair, R. M., Bobba, F., Bode, N., Boër, M., Bogaert, G., Boileau, G., Boldrini, M., Bolingbroke, G. N., Bonavena, L. D., Bondarescu, R., Bondu, F., Bonilla, E., Bonilla, G. S., Bonnand, R., Booker, P., Bork, R., Boschi, V., Bose, N., Bose, S., Bossilkov, V., Boudart, V., Bouffanais, Y., Bozzi, A., Bradaschia, C., Brady, P. R., Braglia, M., Branch, A., Branchesi, M., Brau, J. E., Breschi, M., Briant, T., Brillet, A., Brinkmann, M., Brockill, P., Brooks, A. F., Brooks, J., Brown, D. D., Brunett, S., Bruno, G., Bruntz, R., Bryant, J., Bucci, F., Buchanan, J., Bulashenko, O., Bulik, T., Bulten, H. J., Buonanno, A., Burtnyk, K., Buscicchio, R., Buskulic, D., Buy, C., Byer, R. L., Davies, G. S. Cabourn, Cabras, G., Cabrita, R., Cadonati, L., Caesar, S., Cagnoli, G., Cahillane, C., Bustillo, J. Calderón, Callaghan, J. D., Callister, T. A., Calloni, E., Camp, J. B., Canepa, M., Santoro, G. Caneva, Cannavacciuolo, M., Cannon, K. C., Cao, H., Cao, Z., Capistran, L. A., Capocasa, E., Capote, E., Carapella, G., Carbognani, F., Carlassara, M., Carlin, J. B., Carpinelli, M., Carter, J. J., Carullo, G., Diaz, J. Casanueva, Casentini, C., Castaldi, G., Castro-Lucas, S. Y., Caudill, S., Cavaglià, M., Cavalieri, R., Cella, G., Cerdá-Durán, P., Cesarini, E., Chaibi, W., Chakalis, W., Subrahmanya, S. Chalathadka, Champion, E., Chan, C., Chan, C. L., Chandra, K., Chang, I. P., Chang, W., Chanial, P., Chao, S., Chapman-Bird, C., Charlton, E. L., Charlton, P., Chassande-Mottin, E., Chastain, L., Chatterjee, C., Chatterjee, Debarati, Chatterjee, Deep, Chaturvedi, M., Chaty, S., Chatziioannou, K., Chen, D., Chen, H., Chen, H. Y., Chen, J., Chen, K. H., Chen, X., Chen, Y. -R., Chen, Y., Cheng, H., Chessa, P., Cheung, H. Y., Chia, H. Y., Chiadini, F., Chiang, C-I., Chiang, C., Chiarini, G., Chiba, A., Chiba, R., Chierici, R., Chincarini, A., Chiofalo, M. L., Chiummo, A., Choudhary, S., Christensen, N., Chua, S. S. Y., Chung, K. W., Ciani, G., Ciecielag, P., Cieślar, M., Cifaldi, M., Ciobanu, A. A., Ciolfi, R., Clara, F., Clark, J. A., Clarke, T. A., Clearwater, P., Clesse, S., Cleva, F., Coccia, E., Codazzo, E., Cohadon, P. -F., Colleoni, M., Collette, C. G., Colombo, A., Colpi, M., Compton, C. M., Conti, L., Cooper, S. J., Corban, P., Corbitt, T. R., Cordero-Carrión, I., Corezzi, S., Cornish, N. J., Corsi, A., Cortese, S., Coschizza, A. C., Cottingham, R., Coughlin, M. W., Coulon, J. -P., Countryman, S. T., Coupechoux, J. -F., Cousins, B., Couvares, P., Coward, D. M., Cowart, M. J., Cowburn, B. D., Coyne, D. C., Coyne, R., Craig, K., Creighton, J. D. E., Creighton, T. D., Criswell, A. W., Crockett-Gray, J. C. G., Croquette, M., Crowder, S. G., Cudell, J. R., Cullen, T. J., Cumming, A., Cummings, R., Cuoco, E., Curyło, M., Dabadie, P., Canton, T. Dal, Dall'Osso, S., Dálya, G., D'Angelo, B., Danilishin, S., D'Antonio, S., Danzmann, K., Darroch, K. E., Darsow-Fromm, C., Dasgupta, A., Datrier, L. E. H., Datta, Sayantani, Dattilo, V., Dave, I., Davenport, A., Davier, M., Davis, D., Davis, M. C., Daw, E. J., Dax, M., DeBra, D., Deenadayalan, M., Degallaix, J., De Laurentis, M., Deléglise, S., Del Favero, V., De Lillo, F., De Lillo, N., Dell'Aquila, D., Del Pozzo, W., De Matteis, F., D'Emilio, V., Demos, N., Dent, T., Depasse, A., De Pietri, R., De Rosa, R., De Rossi, C., DeSalvo, R., De Simone, R., Dhurandhar, S., Diab, R., Diamond, P. Z., Díaz, M. C., Didio, N. A., Dietrich, T., Di Fiore, L., Di Fronzo, C., Di Giorgio, C., Di Giovanni, F., Di Giovanni, M., Di Girolamo, T., Diksha, D., Di Lieto, A., Di Michele, A., Di Pace, S., Di Palma, I., Di Renzo, F., Divyajyoti, Dmitriev, A., Doctor, Z., Dohmen, E., Doleva, P. P., Donahue, L., D'Onofrio, L., Donovan, F., Dooley, K. L., Dooney, T., Doravari, S., Dorosh, O., Drago, M., Driggers, J. C., Drori, Y., Ducoin, J. -G., Dunn, L., Dupletsa, U., Durante, O., D'Urso, D., Duverne, P. -A., Dwyer, S. E., Eassa, C., Easter, P. J., Ebersold, M., Eckhardt, T., Eddolls, G., Edelman, B., Edo, T. B., Edy, O., Effler, A., Eichholz, J., Eisenmann, M., Eisenstein, R. A., Ejlli, A., Engelby, E., Engl, A. J., Errico, L., Essick, R. C., Estellés, H., Estevez, D., Etzel, T., Evans, C., Evans, M., Evans, T. M., Evstafyeva, T., Ewing, B. E., Fabrizi, F., Faedi, F., Fafone, V., Fair, H., Fairhurst, S., Fan, P. C., Fan, X., Farah, A. M., Farr, B., Farr, W. M., Fauchon-Jones, E. J., Favaro, G., Favata, M., Fays, M., Feicht, J., Fejer, M. M., Fenyvesi, E., Ferguson, D. L., Fernandez-Galiana, A., Ferrante, I., Ferreira, T. A., Fidecaro, F., Figura, P., Fiori, A., Fiori, I., Fishbach, M., Fisher, R. P., Fittipaldi, R., Fiumara, V., Flaminio, R., Fleischer, S. M., Fleming, L. S., Floden, E., Fong, H. K., Font, J. A., Fornal, B., Forsyth, P. W. F., Franke, A., Frasca, S., Frasconi, F., Freed, J. P., Frei, Z., Freise, A., Freitas, O., Frey, R., Fritschel, P., Frolov, V. V., Fronzé, G. G., Fujimoto, Y., Fukunaga, I., Fulda, P., Fyffe, M., Gabbard, H. A., Gabella, W. E., Gadre, B. U., Gaglani, K., Gair, J. R., Gais, J., Galaudage, S., Gallardo, S., Gamba, R., Ganapathy, D., Ganguly, A., Gao, D., Gaonkar, S. G., Garaventa, B., Garcia-Bellido, J., García-Núñez, C., García-Quirós, C., Gardner, K. A., Gargiulo, J., Garufi, F., Gasbarra, C., Gateley, B., Gayathri, V., Gemme, G., Gennai, A., George, J., Gerberding, O., Gergely, L., Ghonge, S., Ghosh, Abhirup, Ghosh, Archisman, Ghosh, Shaon, Ghosh, Shrobana, Ghosh, Tathagata, Giacoppo, L., Giaime, J. A., Giardina, K. D., Gibson, D. R., Gier, C., Giri, P., Gissi, F., Gkaitatzis, S., Glanzer, J., Gleckl, A. E., Glotin, F., Godfrey, J., Godwin, P., Goetz, E., Goetz, R., Golomb, J., Goncharov, B., González, G., Gosselin, M., Gouaty, R., Gould, D. W., Goyal, S., Grace, B., Grado, A., Graham, V., Granata, M., Granata, V., Gras, S., Grassia, P., Gray, C., Gray, R., Greco, G., Green, A. C., Green, R., Green, S., Green, S. R., Gretarsson, A. M., Gretarsson, E. M., Griffith, D., Griffiths, W. L., Griggs, H. L., Grignani, G., Grimaldi, A., Grote, H., Gruson, A. S., Guerra, D., Guetta, D., Guidi, G. M., Guimaraes, A. R., Gulati, H. K., Gulminelli, F., Gunny, A. M., Guo, H., Guo, Y., Gupta, Anchal, Gupta, Anuradha, Gupta, Ish, Gupta, N. C., Gupta, P., Gupta, S. K., Gurs, J., Gushima, Y., Gustafson, E. K., Gutierrez, N., Guzman, F., Haegel, L., Hain, G., Haino, S., Halim, O., Hall, E. D., Hamilton, E. Z., Hammond, G., Han, W. -B., Haney, M., Hanks, J., Hanna, C., Hannam, M. D., Hannuksela, O. A., Hansen, H., Hanson, J., Harada, R., Harder, T., Haris, K., Harmark, T., Harms, J., Harry, G. M., Harry, I. W., Hartwig, D., Haskell, B., Haster, C. -J., Hathaway, J. S., Haughian, K., Hayakawa, H., Hayama, K., Hayes, F. J., Healy, J., Heffernan, A., Heidmann, A., Heintze, M. C., Heinze, J., Heinzel, J., Heitmann, H., Hellman, F., Hello, P., Helmling-Cornell, A. F., Hemming, G., Hendry, M., Heng, I. S., Hennes, E., Hennig, J. -S., Hennig, M., Henshaw, C., Vivanco, F. Hernandez, Heurs, M., Hewitt, A. L., Higginbotham, S., Hild, S., Hill, P., Himemoto, Y., Hines, A. S., Hirata, N., Hirose, C., Ho, J., Hochheim, S., Hofman, D., Hohmann, J. N., Holcomb, D. G., Holland, N. A., Holley-Bockelmann, K., Hollows, I. J., Holmes, Z. J., Holt, K., Holz, D. E., Hong, Q., Hornung, J., Hoshino, S., Hough, J., Hourihane, S., Howell, D., Howell, E. J., Hoy, C. G., Hoyland, D., Hsieh, B. -H., Hsieh, H. -F., Hsiung, C., Hsu, H., Hu, P., Hu, Q., Huang, H. -Y., Huang, Y. -J., Huang, Y., Huang, Y. T., Hübner, M. T., Huddart, A. D., Hughey, B., Hui, D. C. Y., Hui, V., Husa, S., Huttner, S. H., Huxford, R., Huynh-Dinh, T., Hyland, J., Iakovlev, A., Iandolo, G. A., Idzkowski, B., Iess, A., Inayoshi, K., Inoue, Y., Iorio, G., Iosif, P., Irwin, J., Isi, M., Ismail, M. A., Itoh, Y., Iyer, B. R., JaberianHamedan, V., Jacqmin, T., Jacquet, P. -E., Jadhav, S. J., Jadhav, S. P., Jain, D., Jain, T., James, A. L., Jan, A. Z., Jani, K., Janiurek, L., Janquart, J., Janssens, K., Janthalur, N. N., Jaraba, S., Jaranowski, P., Jarov, S., Jasal, P., Jaume, R., Javed, W., Jenkins, A. C., Jenner, K., Jennings, A., Jia, W., Jiang, J., Liu, Jian, Jin, H. -B., Johansmeyer, K., Johns, G. R., Johnson, N. A., Johnston, R., Johny, N., Jones, A. W., Jones, D. H., Jones, D. I., Jones, P., Jones, R., Joshi, P., Ju, L., Jung, K., Junker, J., Juste, V., Kajita, T., Kalaghatgi, C., Kalogera, V., Kamai, B., Kamiizumi, M., Kanda, N., Kandhasamy, S., Kang, G., Kanner, J. B., Kapadia, S. J., Kapasi, D. P., Karat, S., Karathanasis, C., Karki, S., Kasamatsu, D., Kas-danouche, Y. A., Kashyap, R., Kasprzack, M., Kastaun, W., Kato, J., Katsanevas, S., Katsavounidis, E., Katsuren, J. K., Katzman, W., Kaur, T., Kawabe, K., Kawazoe, K., Kéfélian, F., Keitel, D., Kellard, I., Kelley-Derzon, J., Kennington, J., Key, J. S., Khadka, S., Khalili, F. Y., Khan, S., Khanam, T., Khazanov, E. A., Khursheed, M., Kijbunchoo, N., Kim, C., Kim, J. C., Kim, K., Kim, M. H., Kim, P., Kim, S., Kim, W. S., Kim, Y. -M., Kimball, C., Kimura, N., Kinley-Hanlon, M., Kirchhoff, R., Kissel, J. S., Kiyota, T., Klimenko, S., Klinger, T., Knee, A. M., Knust, N., Kobayashi, Y., Koch, P., Koehlenbeck, S. M., Koekoek, G., Kohri, K., Kokeyama, K., Koley, S., Koliadko, N. D., Kolitsidou, P., Kolstein, M., Kondrashov, V., Kong, A. K. H., Kontos, A., Korobko, M., Kossak, R. V., Kouvatsos, N., Kovalam, M., Koyama, N., Kozak, D. B., Kranzhoff, L., Kranzhoff, S. L., Kringel, V., Krishnendu, N. V., Królak, A., Kuehn, G., Kuijer, P., Kukihara, M., Kulkarni, S., Kumar, A., Kumar, Praveen, Kumar, Prayush, Kumar, Rahul, Kumar, Rakesh, Kume, J., Kuns, K., Kuroyanagi, S., Kuwahara, S., Kwak, K., Lacaille, G., Lagabbe, P., Laghi, D., Lakkis, M. H., Lalande, E., Lalleman, M., Lamberts, A., Landry, M., Lane, B. B., Lang, R. N., Lange, J., Lantz, B., La Rana, A., La Rosa, I., Lartaux-Vollard, A., Lasky, P. D., Lawrence, J., Laxen, M., Lazzarini, A., Lazzaro, C., Leaci, P., Leavey, S., LeBohec, S., Lecoeuche, Y. K., Lee, E., Lee, H. M., Lee, H. W., Lee, K., Lee, R. -L., Lee, R., Lee, S., Legred, I. N., Lehmann, J., Lehner, L., Lemaître, A., Lenti, M., Leonardi, M., Leonova, E., Leroy, N., Letendre, N., Lethuillier, M., Levesque, C., Levin, Y., Leyde, K., Li, A. K. Y., Li, K. L., Li, T. G. F., Li, X., Lin, C. -Y., Lin, E. T., Lin, F-K., Lin, F-L., Lin, F., Lin, H. L., Lin, H., Lin, L. C. -C., Linde, F., Linker, S. D., Littenberg, T. B., Liu, A., Liu, G. C., Llamas, F., Lo, R. K. L., Lo, T., London, L. T., Longo, A., Lopez, D., Portilla, M. Lopez, Lorenzini, M., Loriette, V., Lormand, M., Losurdo, G., Lott, T. P., Lough, J. D., Loughlin, H. A., Lousto, C. O., Lovelace, G., Lowry, M. J., Lück, H., Lumaca, D., Lundgren, A. P., Lung, Y., Lussier, A. W., Lynam, J. E., Ma, L., Ma, S., Ma'arif, M., Macas, R., MacInnis, M., Macleod, D. M., MacMillan, I. A. O., Macquet, A., Hernandez, I. Magaña, Magazzù, C., Magee, R. M., Maggiore, R., Magnozzi, M., Mahesh, M., Mahesh, S., Maini, M., Majorana, E., Makarem, C. N., Maliakal, S., Malik, A., Man, N., Mandic, V., Mangano, V., Mannix, B., Mansell, G. L., Mansingh, G., Manske, M., Mantovani, M., Mapelli, M., Marchesoni, F., Pina, D. Marín, Marion, F., Márka, S., Márka, Z., Markakis, C., Markosyan, A. S., Markowitz, A., Maros, E., Marquina, A., Marsat, S., Martelli, F., Martin, I. W., Martin, R. M., Martinez, B. B., Martinez, M., Martinez, V. A., Martinez, V., Martinovic, K., Martynov, D. V., Marx, E. J., Masalehdan, H., Mason, K., Masserot, A., Reid, M. Masso, Mastrodicasa, M., Mastrogiovanni, S., Mateu-Lucena, M., Matiushechkina, M., Matsunaga, K., Mavalvala, N., McCarthy, R., McClelland, D. E., McClincy, P. K., McCormick, S., McCuller, L., McGhee, G. I., McGinn, J., McIsaac, C., McIver, J., McLeod, A., McRae, T., McWilliams, S. T., Meacher, D., Mehmet, M., Mehta, A. K., Meijer, Q., Melatos, A., Mendell, G., Menendez-Vazquez, A., Menoni, C. S., Mercer, R. A., Mereni, L., Merfeld, K., Merilh, E. L., Merritt, J. D., Merzougui, M., Messenger, C., Messick, C., Meyers, P. M., Meylahn, F., Mhaske, A., Miani, A., Miao, H., Michaloliakos, I., Michel, C., Michimura, Y., Middleton, H., Mihaylov, D. P., Miller, A., Miller, A. L., Miller, B., Miller, S., Millhouse, M., Mills, J. C., Milotti, E., Minenkov, Y., Mio, N., Mir, Ll. M., Miravet-Tenés, M., Mishra, A., Mishra, C., Mishra, T., Mistry, T., Mitchell, A. L., Mitra, S., Mitrofanov, V. P., Mitselmakher, G., Mittleman, R., Miyakawa, O., Miyoki, S., Mo, Geoffrey, Modafferi, L. M., Moguel, E., Mohapatra, S. R. P., Mohite, S. R., Molina-Ruiz, M., Mondal, C., Mondin, M., Montani, M., Moore, C. J., Moragues, J., Moraru, D., Morawski, F., More, A., More, S., Moreno, C., Moreno, G., Morisaki, S., Moriwaki, Y., Morras, G., Moscatello, A., Mours, B., Mow-Lowry, C. M., Mozzon, S., Muciaccia, F., Mukherjee, D., Mukherjee, Soma, Mukherjee, Subroto, Mukherjee, Suvodip, Mukund, N., Mullavey, A., Munch, J., Muñiz, E. A., Murray, P. G., Murray-Dean, J., Muusse, S., Nadji, S. L., Nagar, A., Nagar, T., Nagarajan, N., Nakamura, K., Nakano, H., Nakano, M., Nakayama, Y., Napolano, V., Nardecchia, I., Narikawa, T., Narola, H., Naticchioni, L., Nayak, R. K., Neil, B. F., Neilson, J., Nelson, A., Nelson, T. J. N., Nery, M., Nesseris, S., Neunzert, A., Ng, K. Y., Ng, S. W. S., Nguyen, C., Nguyen, P., Nguyen, R., Nguyen, T., Quynh, L. Nguyen, Nichols, S. A., Nieradka, G., Nishino, Y., Nishizawa, A., Nissanke, S., Nitoglia, E., Niu, W., Nocera, F., Norman, M., North, C., Novak, J., Siles, J. F. Nuño, Nurbek, G., Nuttall, L. K., Oberling, J., O'Dell, J., Oelker, E., Oertel, M., Oganesyan, G., Oh, J. J., Oh, K., Oh, S. H., O'Hanlon, T., Ohashi, M., Ohashi, T., Ohkawa, M., Ohme, F., Ohta, H., Oliveira, A. S., Oliveri, R., Oohara, K., O'Reilly, B., Ormiston, R. G., Ormsby, N. D., Orselli, M., O'Shaughnessy, R., O'Shea, E., Oshima, Y., Oshino, S., Ossokine, S., Osthelder, C., Ottaway, D. J., Overmier, H., Pace, A. E., Pagano, R., Page, M. A., Pai, A., Pai, S. A., Pal, S., Palashov, O., Pálfi, M., Palomba, C., Pan, K. C., Panda, P. K., Pang, P. T. H., Pannarale, F., Pant, B. C., Panther, F. H., Paoletti, F., Paoli, A., Paolone, A., Papalexakis, E. E., Pappas, G., Parisi, A., Park, J., Parker, W., Pascucci, D., Pasqualetti, A., Passaquieti, R., Passuello, D., Patel, M., Pathak, M., Patra, A., Patricelli, B., Patron, A. S., Paul, S., Payne, E., Pearce, T., Pedraza, M., Pedurand, R., Pegna, R., Pegoraro, M., Pele, A., Arellano, F. E. Peña, Penn, S., Perego, A., Pereira, A., Perez, C. J., Périgois, C., Perkins, C. C., Perreca, A., Perriès, S., Perry, J. W., Pesios, D., Petermann, J., Petrillo, C., Pfeiffer, H. P., Pham, H., Pham, K. A., Phukon, K. S., Phurailatpam, H., Piccinni, O. J., Pichot, M., Piendibene, M., Piergiovanni, F., Pierini, L., Pierra, G., Pierro, V., Pillant, G., Pillas, M., Pilo, F., Pinard, L., Pineda-Bosque, C., Pinto, I. M., Piotrzkowski, B. J., Piotrzkowski, K., Pirello, M., Pitkin, M. D., Placidi, A., Placidi, E., Planas, M. L., Plastino, W., Poggiani, R., Polini, E., Pompili, L., Pong, D. Y. T., Ponrathnam, S., Porcelli, E., Portell, J., Porter, E. K., Posnansky, C., Poulton, R., Powell, Jade, Powell, Jonathan, Pracchia, M., Pradier, T., Prajapati, A. K., Prasai, K., Prasanna, R., Pratten, G., Principe, M., Prodi, G. A., Prokhorov, L., Prosposito, P., Prudenzi, L., Puecher, A., Pullin, J., Punturo, M., Puosi, F., Puppo, P., Pürrer, M., Qi, H., Quetschke, V., Quinonez, P. J., Quitzow-James, R., Raab, F. J., Raaijmakers, G., Radulesco, N., Raffai, P., Rail, S. X., Raja, S., Rajan, C., Ramirez, K. E., Ramirez, T. D., Ramos-Buades, A., Rana, D., Rana, J., Randel, E., Rangnekar, P. R., Rapagnani, P., Ray, A., Raymond, V., Raza, N., Razzano, M., Read, J., Regimbau, T., Rei, L., Reid, S., Reid, S. W., Reitze, D. H., Relton, P., Renzini, A., Rettegno, P., Revenu, B., Reza, A., Rezac, M., Rezaei, A. S., Ricci, F., Richards, D., Richardson, J. W., Rijal, A., Riles, K., Riley, H. K., Rinaldi, S., Robertson, C., Robertson, N. A., Robinet, F., Rocchi, A., Rodriguez, S., Rolland, L., Rollins, J. G., Romanelli, M., Romano, R., Romel, C. L., Romero, A., Romero-Shaw, I. M., Romie, J. H., Ronchini, S., Roocke, T. J., Rosa, L., Rosauer, T. J., Rose, C. A., Rosińska, D., Ross, M. P., Rossello, M., Roussel, A., Rowan, S., Rowlinson, S. J., Roy, S., Royzman, A., Rozza, D., Ruggi, P., Morales, E. Ruiz, Ruiz-Rocha, K., Ryan, K., Sachdev, S., Sadecki, T., Sadiq, J., Saffarieh, P., Saha, S. S., Saha, S., Saito, Y., Sakai, K., Sakellariadou, M., Sako, T., Sakon, S., Salafia, O. S., Salces-Carcoba, F., Salconi, L., Saleem, M., Salemi, F., Sallé, M., Samajdar, A., Sanchez, E. J., Sanchez, J. H., Sanchez, L. E., Sanchis-Gual, N., Sanders, J. R., Sanuy, A., Saravanan, T. R., Sarin, N., Sasli, A., Sassi, P., Sassolas, B., Satari, H., Sauter, O., Savage, R. L., Savant, V., Sawada, T., Sawant, H. L., Sayah, S., Schaetzl, D., Scheel, M., Scherf, S. J., Scheuer, J., Schiworski, M. G., Schmidt, P., Schmidt, S., Schmitz, S. J., Schnabel, R., Schneewind, M., Schofield, R. M. S., Schönbeck, A., Schuler, H., Schulte, B. W., Schutz, B. F., Schwartz, E., Scott, J., Scott, S. M., Seetharamu, T. C., Seglar-Arroyo, M., Sekiguchi, Y., Sellers, D., Sengupta, A. S., Sentenac, D., Seo, E. G., Sequino, V., Sergeev, A., Servignat, G., Setyawati, Y., Shaffer, T., Shahriar, M. S., Shaikh, M. A., Shams, B., Shao, L., Sharma, P., Chaudhary, S. Sharma, Shawhan, P., Shcheblanov, N. S., Sheela, A., Shen, B., Shepard, K. G., Sheridan, E., Shikano, Y., Shikauchi, M., Shimizu, H., Shimode, K., Shinkai, H., Shoemaker, D. H., Shoemaker, D. M., ShyamSundar, S., Sider, A., Siegel, H., Sieniawska, M., Sigg, D., Silenzi, L., Singer, L. P., Singh, D., Singh, M. K., Singh, N., Singha, A., Sintes, A. M., Sipala, V., Skliris, V., Slagmolen, B. J. J., Slaven-Blair, T. J., Smetana, J., Smith, J. R., Smith, L., Smith, R. J. E., Soldateschi, J., Somala, S. N., Somiya, K., Soni, K., Soni, S., Sordini, V., Sorrentino, F., Sorrentino, N., Sotani, H., Soulard, R., Souradeep, T., Sowell, E., Spagnuolo, V., Spencer, A. P., Spera, M., Spinicelli, P., Srivastava, A. K., Srivastava, V., Stachie, C., Stachurski, F., Steer, D. A., Steinlechner, J., Steinlechner, S., Stergioulas, N., StPierre, M., Strang, L. C., Stratta, G., Strong, M. D., Strunk, A., Sturani, R., Stuver, A. L., Suchenek, M., Sudhagar, S., Sueltmann, N., Sugiyama, T., Suh, H. G., Sullivan, A. G., Summerscales, T. Z., Sun, L., Sunil, S., Sur, A., Suresh, J., Sutton, P. J., Suzuki, Takamasa, Suzuki, Takanori, Swinkels, B. L., Syx, A., Szczepańczyk, M. J., Szewczyk, P., Tacca, M., Tagoshi, H., Tait, S. C., Takahashi, H., Takahashi, R., Takamori, A., Takano, S., Takeda, H., Takeda, M., Talbot, C. J., Talbot, C., Tamaki, M., Tamanini, N., Tanabe, D., Tanaka, K., Tanaka, T., Tanasijczuk, A. J., Tanioka, S., Tanner, D. B., Tao, D., Tao, L., Tapia, R. D., Martín, E. N. Tapia San, Tarafder, R., Taranto, C., Taruya, A., Tasson, J. D., Teloi, M., Tenorio, R., Terhune, J. E. S., Terkowski, L., Themann, H., Thirugnanasambandam, M. P., Thomas, L. M., Thomas, M., Thomas, P., Thomas, S., Thompson, J. E., Thondapu, S. R., Thorne, K. A., Thrane, E., Tiwari, Shubhanshu, Tiwari, Srishti, Tiwari, V., Toivonen, A. M., Tolley, A. E., Tomaru, T., Tomita, K., Tomura, T., Tonelli, M., Torres-Forné, A., Torrie, C. I., Melo, I. Tosta e, Tournefier, E., Trapananti, A., Travasso, F., Traylor, G., Trenado, J., Trevor, M., Tringali, M. C., Tripathee, A., Troiano, L., Trovato, A., Trozzo, L., Trudeau, R. J., Tsang, K. W., Tsang, T., Tse, M., Tso, R., Tsuchida, S., Tsukada, L., Tsutsui, T., Turbang, K., Turconi, M., Turski, C., Tuyenbayev, D., Ubach, H., Ubhi, A. S., Uchikata, N., Uchiyama, T., Udall, R. P., Uehara, T., Ueno, K., Unnikrishnan, C. S., Ushiba, T., Utina, A., Vahlbruch, H., Vaidya, N., Vajente, G., Vajpeyi, A., Valdes, G., Valentini, M., Vallero, S., Valsan, V., van Bakel, N., van Beuzekom, M., van Dael, M., Brand, J. F. J. van den, Broeck, C. Van Den, Vander-Hyde, D. C., van der Sluys, M., Van de Walle, A., van Dongen, J., van Haevermaet, H., van Heijningen, J. V., Vanosky, J., van Putten, M. H. P. M., van Ranst, Z., van Remortel, N., Vardaro, M., Vargas, A. F., Varma, V., Vasúth, M., Vecchio, A., Vedovato, G., Veitch, J., Veitch, P. J., Venneberg, J., Venugopalan, G., Verdier, P., Verkindt, D., Verma, P., Verma, Y., Vermeulen, S. M., Veske, D., Vetrano, F., Viceré, A., Vidyant, S., Viets, A. D., Vijaykumar, A., Villa-Ortega, V., Vina, M., Vincent, E. T., Vinet, J. -Y., Viret, S., Virtuoso, A., Vitale, S., Vocca, H., Voigt, D., von Reis, E. R. G., von Wrangel, J. S. A., Vorvick, C., Vyatchanin, S. P., Wade, L. E., Wade, M., Wagner, K. J., Walet, R. C., Walker, M., Wallace, G. S., Wallace, L., Wang, H., Wang, J. Z., Wang, W. H., Ward, R. L., Warner, J., Was, M., Washimi, T., Washington, N. Y., Watada, K., Watarai, D., Watchi, J., Wayt, K. E., Weaver, B., Weaving, C. R., Webster, S. A., Weinert, M., Weinstein, A. J., Weiss, R., Weller, C. M., Weller, R. A., Wellmann, F., Wen, L., Weßels, P., Wette, K., Whelan, J. T., White, D. D., Whiting, B. F., Whittle, C., Wilk, O. S., Wilken, D., Willetts, K., Williams, D., Williams, M. J., Williamson, A. R., Willis, J. L., Willke, B., Wipf, C. C., Woan, G., Woehler, J., Wofford, J. K., Wong, D., Wong, H. T., Wong, I. C. F., Wright, M., Wu, C., Wu, D. S., Wu, H., Wysocki, D. M., Xiao, L., Xu, V. A., Yadav, N., Yamada, T., Yamamoto, H., Yamamoto, K., Yamamoto, M., Yamamoto, T., Yamamoto, T. S., Yamashita, K., Yamazaki, R., Yang, F. W., Yang, K. Z., Yang, Y. -C., Yap, M. J., Yeeles, D. W., Yelikar, A. B., Yeung, T. Y., Yokoyama, J., Yokozawa, T., Yoo, J., Yu, Hang, Yu, Haocun, Yuzurihara, H., Zadrożny, A., Zannelli, A. J., Zanolin, M., Zeeshan, M., Zeidler, S., Zelenova, T., Zendri, J. -P., Zevin, M., Zhang, J., Zhang, L., Zhang, R., Zhang, T., Zhang, Y., Zhao, C., Zhao, Yue, Zhao, Yuhang, Zheng, Y., Zhong, H., Zhou, R., Zhu, X. J., Zhu, Z. -H., Zimmerman, A. B., Zucker, M. E., and Zweizig, J.

Subjects
General Relativity and Quantum Cosmology
Abstract

The global network of gravitational-wave observatories now includes five detectors, namely LIGO Hanford, LIGO Livingston, Virgo, KAGRA, and GEO 600. These detectors collected data during their third observing run, O3, composed of three phases: O3a starting in April of 2019 and lasting six months, O3b starting in November of 2019 and lasting five months, and O3GK starting in April of 2020 and lasting 2 weeks. In this paper we describe these data and various other science products that can be freely accessed through the Gravitational Wave Open Science Center at https://gwosc.org. The main dataset, consisting of the gravitational-wave strain time series that contains the astrophysical signals, is released together with supporting data useful for their analysis and documentation, tutorials, as well as analysis software packages., Comment: 27 pages, 3 figures

Published
2023
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74. Privilege

Author

SHEPARD, JIM

Published
2023

75. Preliminary experience using MR-guided adaptive radiotherapy in head and neck cancer

Author

Caiden Atienza, Andrew Shepard, Uwajachukwumma Uzomah, Shri Kiriti Rajan, Carryn M. Anderson, Joel Katzer, Samuel Rusu, Joel St-Aubin, Blake Smith, and Daniel Hyer

Subjects
adaptive, radiotherapy, benefit, MR-linac, organs-at-risk, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

This retrospective study evaluates the dosimetric benefits of adaptive radiotherapy for head and neck cancer patients. Five patients with node-positive oropharyngeal squamous cell carcinoma were treated with MR-guided radiotherapy using the Elekta Unity MR-Linac, undergoing 3-4 offline adaptive plan modifications during their treatment. This study compared the dose delivered to organs at risk (OARs) in a full offline adaptive approach versus an approach accounting only for daily setup. Results demonstrated a reduction in mean dose to critical structures in the offline adaptive arm. For example, the pharynx avoidance structure showed mean dose reductions ranging from 1.4 Gy to 3.6 Gy, and the left parotid gland exhibited reductions from 1.5 Gy to 1.9 Gy. Overall, offline adaptive radiotherapy reduced the mean cumulative dose to OARs in 19 of the 23 evaluated structures. Despite some instances of higher doses, the offline adaptive approach generally resulted in lower cumulative doses, emphasizing its potential to mitigate radiation-induced side effects. These findings suggest that offline adaptive radiotherapy has the potential to enhance treatment efficacy by better accommodating anatomical changes during therapy, thereby improving patient outcomes and reducing treatment-related morbidity.

Published
2024
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76. A translational study evaluating a ruggedized portable oxygen concentrator versus an oxygen cylinder in simulated polytrauma intubation of swine

Author

Craig Nowadly, Nola Shepard, Montane Silverman, and Jason Rall

Subjects
hypoxia, intubation, oxygen, portable oxygen concentrator, swine, trauma, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract Objectives Portable oxygen concentrators (POCs) are medical devices that use filters to selectively remove nitrogen from ambient air to produce concentrated, medical‐grade oxygen. This is the first study to evaluate a ruggedized POC's performance during simulated polytrauma intubation. Methods Twenty‐seven swine were intubated and anesthetized with ketamine. At T = 0, animals were extubated, received a chest wall injury, a tibia fracture, and 20% total blood volume controlled hemorrhage was initiated. At T = 10 min, the swine were pre‐oxygenated using a bag‐valve mask connected to one of three randomized oxygen sources: (1) a ruggedized POC, (2) a M‐15 oxygen cylinder, or (3) room air (control). At T = 12 min, animals were re‐intubated to simulate polytrauma intubation and connected to the test oxygen source for the remainder of the experiment. Surviving animals entered a 2‐h period where partial pressure of oxygen (PaO2), oxygen saturation (SpO2), and regional oxygen saturation (rSO2) were monitored. Groups were compared using analysis of variance (ANOVA), Fisher's exact, log‐rank analysis, or mixed‐effects model as appropriate. Results All animals survived except one in the POC group. Mixed‐effects models revealed differences between groups with regards to PaO2 (p

Published
2024
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77. Acetylation of SAMHD1 at lysine 580 is crucial for blocking HIV-1 infection

Author

Angel Bulnes-Ramos, Kerstin Schott, Jesse Rabinowitz, Charlotte Luchsinger, Cinzia Bertelli, Eri Miyagi, Corey H. Yu, Mirjana Persaud, Caitlin Shepard, Renate König, Baek Kim, Dmitri N. Ivanov, Klaus Strebel, and Felipe Diaz-Griffero

Subjects
HIV-1, SAMHD1, restriction, acetylation, K580, innate immunity, Microbiology, QR1-502
Abstract

ABSTRACT In humans, sterile alpha motif (SAM) domain- and histidine–aspartic acid (HD) domain-containing protein 1 (SAMHD1) is a dNTPase enzyme that prevents HIV-1 infection in non-cycling cells, such as differentiated THP-1 cells and human primary macrophages. Although phosphorylation of threonine 592 (T592) in SAMHD1 is recognized as the primary regulator of the ability to prevent HIV-1 infection, the contributions of SAMHD1 acetylation to this ability remain unknown. Mass spectrometry analysis of SAMHD1 proteins derived from cycling and non-cycling THP-1 cells, primary cycling B cells, and primary macrophages revealed that SAMHD1 is preferentially acetylated at lysine residues 354, 494, and 580 (K354, K494, and K580). In non-cycling cells, SAMHD1 is preferentially acetylated at K580, suggesting that this post-translational modification may contribute to the ability of SAMHD1 to block HIV-1 infection. Consistent with this finding, we found that mutations in K580 disrupted the ability of SAMHD1 to block HIV-1 infection without affecting the ability of SAMHD1 to deplete cellular dNTP levels. Gene editing of SAMHD1 in macrophage-like cells revealed that an intact K580 is required for HIV-1 restriction. This finding suggests that K580 acetylation in SAMHD1 is essential for blocking HIV-1 infection. More importantly, we found that a larger proportion of SAMHD1 featuring K580 acetylation could be detected in human primary macrophages when compared to human primary monocytes. In agreement, we found that SAMHD1 is acetylated during the monocyte-to-macrophage differentiation process. This finding agrees with the idea that the blockade of HIV-1 infection in macrophages requires SAMHD1 acetylation.IMPORTANCEThe natural inhibitor of HIV-1, sterile alpha motif (SAM) domain- and histidine–aspartic acid (HD) domain-containing protein 1 (SAMHD1), plays a pivotal role in preventing HIV-1 infection of macrophages and dendritic cells, which are vital components of the immune system. This study unveils that SAMHD1 undergoes post-translational modifications, specifically acetylation at lysines 354, 494, and 580. Our research underscores the significance of these modifications, demonstrating that acetylation at residue K580 is indispensable for SAMHD1's efficacy in blocking HIV-1 infection. Notably, K580 is found in a critical regulatory domain of SAMHD1, highlighting acetylation as a novel layer of SAMHD1 regulation for HIV-1 restriction in humans. A comprehensive understanding of the regulation mechanisms governing this anti-HIV-1 protein is crucial for leveraging nature's defense mechanisms against HIV-1 and could pave the way for innovative therapeutic strategies.

Published
2024
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81. Towards Equitable, Bi-directional, and Reflexive Research Collaborations in English Language Teaching

Author

Wong, Mary Shepard, Kareng, David, Hult, Francis M., Series Editor, Cavalcanti, Marilda C., Editorial Board Member, Cenoz, Jasone, Editorial Board Member, Creese, Angela, Editorial Board Member, Gogolin, Ingrid, Editorial Board Member, Hélot, Christine, Editorial Board Member, Janks, Hilary, Editorial Board Member, Kramsch, Claire, Editorial Board Member, Leung, Constant, Editorial Board Member, Lin, Angel, Editorial Board Member, Pennycook, Alastair, Editorial Board Member, Curtis, Jessie Hutchison, editor, and Uştuk, Özgehan, editor

Published
2024
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82. Cultivating Co-learning in Participatory Design for Translanguaging Pedagogies

Author

Shepard-Carey, Leah, Hult, Francis M., Series Editor, Cavalcanti, Marilda C., Editorial Board Member, Cenoz, Jasone, Editorial Board Member, Creese, Angela, Editorial Board Member, Gogolin, Ingrid, Editorial Board Member, Hélot, Christine, Editorial Board Member, Janks, Hilary, Editorial Board Member, Kramsch, Claire, Editorial Board Member, Leung, Constant, Editorial Board Member, Lin, Angel, Editorial Board Member, Pennycook, Alastair, Editorial Board Member, Curtis, Jessie Hutchison, editor, and Uştuk, Özgehan, editor

Published
2024
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83. Robust Functional Magnetoencephalographic Brain Measures with 1.0 Millimeter Spatial Separation

Author

Krieger, Don, Shepard, Paul, and Okonkwo, David O.

Subjects
Quantitative Biology - Neurons and Cognition
Abstract

Neuroelectric currents were extracted from free-running magnetoencephalographic (MEG) rest and task recordings from 617 normative subjects (ages: 18-87). State-dependent neuroelectric differential activation (DA) with spatial resolution comparable to that of local field potentials was detected in the majority of this cohort. Rest-high (rest greater than task) or task-high DA was found in the majority of individual subjects in more than 13,000 1 mm^3 voxels per subject. On average, 6% of the DA voxels bordered a second voxel whose DA was opposite, i.e., one was rest-high and the other was task-high. 516 subjects showed more than 100 such opposite voxel pairs 1 mm apart; 226 subjects showed more than 1000. The number of bordering voxel pairs with the same DA was consistently higher for almost all subjects and averaged 20%, ruling out the possibility that opposite bordering voxels occur simply by chance. For 65 brain regions, more than 10% of the cohort showed significantly more same than opposite pairs. These findings taken together support the conclusion that neuroelectric DA is consistently distinguishable at single 1 mm^3 brain voxels with 1-mm spatial separation. When restricted to voxels with near-zero rest or task counts, significantly more rest-high than task-high voxels were found in 35 regions for at least 10 percent of the subjects. This inequality was not found when all DA-voxels were included. This supports the conclusion that the DA found in many rest-high voxels with near-zero task counts is due in part to task-dependent inhibition., Comment: 14 pages, 4 figures

Published
2022

84. Role of substrate clamping on anisotropy and domain structure in the canted antiferromagnet $\alpha$-Fe$_2$O$_3$

Author

Wittmann, Angela, Gomonay, Olena, Litzius, Kai, Kaczmarek, Allison, Kossak, Alexander E., Wolf, Daniel, Lubk, Axel, Johnson, Tyler N., Tremsina, Elizaveta A., Churikova, Alexandra, Büttner, Felix, Wintz, Sebastian, Mawass, Mohamad-Assaad, Weigand, Markus, Kronast, Florian, Scipioni, Larry, Shepard, Adam, Newhouse-Illig, Ty, Greer, James A, Schütz, Gisela, Birge, Norman O., and Beach, Geoffrey S. D.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Materials Science
Abstract

Antiferromagnets have recently been propelled to the forefront of spintronics by their high potential for revolutionizing memory technologies. For this, understanding the formation and driving mechanisms of the domain structure is paramount. In this work, we investigate the domain structure in a thin-film canted antiferromagnet $\alpha$-Fe$_2$O$_3$. We find that the internal destressing fields driving the formation of domains do not follow the crystal symmetry of $\alpha$-Fe$_2$O$_3$, but fluctuate due to substrate clamping. This leads to an overall isotropic distribution of the N\'eel order with locally varying effective anisotropy in antiferromagnetic thin films. Furthermore, we show that the weak ferromagnetic nature of $\alpha$-Fe$_2$O$_3$ leads to a qualitatively different dependence on magnetic field compared to collinear antiferromagnets such as NiO. The insights gained from our work serve as a foundation for further studies of electrical and optical manipulation of the domain structure of antiferromagnetic thin films., Comment: 9 pages, 5 figures

Published
2022
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87. (Re)imagining Translanguaging Pedagogies through Teacher-Researcher Collaboration. Translanguaging in Theory and Practice

Author

Shepard-Carey, Leah, Tian, Zhongfeng, Shepard-Carey, Leah, and Tian, Zhongfeng

Abstract

This book presents one possible pathway towards the advancement of translanguaging pedagogies: teacher-researcher partnerships. Although the existing literature alludes to the value of such partnerships, there is a lack of research that explicitly describes the complex processes of designing and implementing translanguaging pedagogies in primary and secondary school settings (K-12) across various international contexts. Through an expanded focus on teacher-researcher collaboration and the negotiation process, the book unpacks the opportunities and challenges of engaging in contextualized translanguaging designs with reference to broader ideological discourses and systemic structures. By promoting and highlighting teacher-researcher partnerships as one avenue for improvement and transparency, the chapters in this book demonstrate the potential of translanguaging pedagogies in classrooms and further resist the linguistic hierarchies that exist in educational institutions today.

Published
2023

88. A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain

Author

Yao, Zizhen, van Velthoven, Cindy T. J., Kunst, Michael, Zhang, Meng, McMillen, Delissa, Lee, Changkyu, Jung, Won, Goldy, Jeff, Abdelhak, Aliya, Aitken, Matthew, Baker, Katherine, Baker, Pamela, Barkan, Eliza, Bertagnolli, Darren, Bhandiwad, Ashwin, Bielstein, Cameron, Bishwakarma, Prajal, Campos, Jazmin, Carey, Daniel, Casper, Tamara, Chakka, Anish Bhaswanth, Chakrabarty, Rushil, Chavan, Sakshi, Chen, Min, Clark, Michael, Close, Jennie, Crichton, Kirsten, Daniel, Scott, DiValentin, Peter, Dolbeare, Tim, Ellingwood, Lauren, Fiabane, Elysha, Fliss, Timothy, Gee, James, Gerstenberger, James, Glandon, Alexandra, Gloe, Jessica, Gould, Joshua, Gray, James, Guilford, Nathan, Guzman, Junitta, Hirschstein, Daniel, Ho, Windy, Hooper, Marcus, Huang, Mike, Hupp, Madie, Jin, Kelly, Kroll, Matthew, Lathia, Kanan, Leon, Arielle, Li, Su, Long, Brian, Madigan, Zach, Malloy, Jessica, Malone, Jocelin, Maltzer, Zoe, Martin, Naomi, McCue, Rachel, McGinty, Ryan, Mei, Nicholas, Melchor, Jose, Meyerdierks, Emma, Mollenkopf, Tyler, Moonsman, Skyler, Nguyen, Thuc Nghi, Otto, Sven, Pham, Trangthanh, Rimorin, Christine, Ruiz, Augustin, Sanchez, Raymond, Sawyer, Lane, Shapovalova, Nadiya, Shepard, Noah, Slaughterbeck, Cliff, Sulc, Josef, Tieu, Michael, Torkelson, Amy, Tung, Herman, Valera Cuevas, Nasmil, Vance, Shane, Wadhwani, Katherine, Ward, Katelyn, Levi, Boaz, Farrell, Colin, Young, Rob, Staats, Brian, Wang, Ming-Qiang Michael, Thompson, Carol L., Mufti, Shoaib, Pagan, Chelsea M., Kruse, Lauren, Dee, Nick, Sunkin, Susan M., Esposito, Luke, Hawrylycz, Michael J., Waters, Jack, Ng, Lydia, Smith, Kimberly, Tasic, Bosiljka, Zhuang, Xiaowei, and Zeng, Hongkui

Published
2023
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91. Phase 1 dose expansion and biomarker study assessing first-in-class tumor microenvironment modulator VT1021 in patients with advanced solid tumors

Author

Jian Jenny Chen, Melanie Y. Vincent, Dale Shepard, David Peereboom, Devalingam Mahalingam, James Battiste, Manish R. Patel, Dejan Juric, Patrick Y. Wen, Andrea Bullock, Jennifer Eva Selfridge, Shubham Pant, Joyce Liu, Wendy Li, Susanne Fyfe, Suming Wang, Victor Zota, James Mahoney, Randolph S. Watnick, Michael Cieslewicz, and Jing Watnick

Subjects
Medicine
Abstract

Abstract Background Preclinical studies have demonstrated that VT1021, a first-in-class therapeutic agent, inhibits tumor growth via stimulation of thrombospondin-1 (TSP-1) and reprograms the tumor microenvironment. We recently reported data from the dose escalation part of a phase I study of VT1021 in solid tumors. Here, we report findings from the dose expansion phase of the same study. Methods We analyzed the safety and tolerability, clinical response, and biomarker profile of VT1021 in the expansion portion of the phase I study (NCT03364400). Safety/tolerability is determined by adverse events related to the treatment. Clinical response is determined by RECIST v1.1 and iRECIST. Biomarkers are measured by multiplexed ion beam imaging and enzyme-linked immunoassay (ELISA). Results First, we report the safety and tolerability data as the primary outcome of this study. Adverse events (AE) suspected to be related to the study treatment (RTEAEs) are mostly grade 1–2. There are no grade 4 or 5 adverse events. VT1021 is safe and well tolerated in patients with solid tumors in this study. We report clinical responses as a secondary efficacy outcome. VT1021 demonstrates promising single-agent clinical activity in recurrent GBM (rGBM) in this study. Among 22 patients with rGBM, the overall disease control rate (DCR) is 45% (95% confidence interval, 0.24-0.67). Finally, we report the exploratory outcomes of this study. We show the clinical confirmation of TSP-1 induction and TME remodeling by VT1021. Our biomarker analysis identifies several plasmatic cytokines as potential biomarkers for future clinical studies. Conclusions VT1021 is safe and well-tolerated in patients with solid tumors in a phase I expansion study. VT1021 has advanced to a phase II/III clinical study in glioblastoma (NCT03970447).

Published
2024
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92. Screening for symptoms of childhood traumatic stress in the primary care pediatric clinic

Author

Kristine A. Campbell, Kara A. Byrne, Brian L. Thorn, Lindsay Shepard Abdulahad, R. Neal Davis, Lisa L. Giles, and Brooks R. Keeshin

Subjects
Traumatic stress, Screening, Mental health, Primary care, Pediatrics, RJ1-570
Abstract

Abstract Background Childhood traumatic experiences may result in post-traumatic stress disorder. Although pediatricians are encouraged to address these traumas in clinical encounters, measures of childhood traumatic stress have not been adopted by primary care clinicians. In this study, we describe the feasibility and potential utility of the UCLA Brief Screen, a validated screener for childhood traumatic stress symptoms, in pediatric primary care clinics. Methods Children 6–17 years of age presenting for routine well-child care in community-based pediatric clinics were eligible for traumatic stress screening. We described the feasibility and acceptability of screening based on screener adoption by eligible pediatric clinicians. We assessed the potential utility of screening based on prevalence and distribution of potentially traumatic events and traumatic stress symptoms in this general pediatric population. Finally, we compared results of the UCLA Brief Screen with those of the Patient Health Questionnaire-A to evaluate associations between symptoms of traumatic stress, depression, and suicidality among adolescents in this community setting. Results 14/18 (77.8%) pediatric clinicians in two clinics offered an adapted UCLA Brief Screen during 2359/4959 (47.6%) eligible well-child checks over 14 months. 1472/2359 (62.4%) of offered screeners were completed, returned, and scored. One-third (32.5%) of completed screeners captured a potentially traumatic event experience described by either children or caregivers. Moderate to severe traumatic stress symptoms were identified in 10.7% and 5.2% of patients, respectively. Concurrent depression screening revealed that 68.3% of adolescents with depressive symptoms reported a potentially traumatic event (PTE) and 80.5% had concurrent traumatic stress symptoms. Adolescents reporting a PTE were 3.5 times more likely to report thoughts of suicide or self-harm than those without this history. Conclusions Results from this pilot study suggest that traumatic stress screening in the pediatric primary care setting may be feasible and may identify and classify mental health symptoms missed with current screening practices for depression. The prevalence of PTEs and traumatic stress symptoms associated with PTEs support the potential utility of a standardized screening in early identification of and response to children with clinically important symptoms of childhood traumatic stress. Future research should evaluate meaningful clinical outcomes associated with traumatic stress screening.

Published
2024
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93. AKAP150-anchored PKA regulates synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the mouse lateral habenula

Author

Sarah C. Simmons, William J. Flerlage, Ludovic D. Langlois, Ryan D. Shepard, Christopher Bouslog, Emily H. Thomas, Kaitlyn M. Gouty, Jennifer L. Sanderson, Shawn Gouty, Brian M. Cox, Mark L. Dell’Acqua, and Fereshteh S. Nugent

Subjects
Biology (General), QH301-705.5
Abstract

Abstract The scaffolding A-kinase anchoring protein 150 (AKAP150) is critically involved in kinase and phosphatase regulation of synaptic transmission/plasticity, and neuronal excitability. Emerging evidence also suggests that AKAP150 signaling may play a key role in brain’s processing of rewarding/aversive experiences, however its role in the lateral habenula (LHb, as an important brain reward circuitry) is completely unknown. Using whole cell patch clamp recordings in LHb of male wildtype and ΔPKA knockin mice (with deficiency in AKAP-anchoring of PKA), here we show that the genetic disruption of PKA anchoring to AKAP150 significantly reduces AMPA receptor-mediated glutamatergic transmission and prevents the induction of presynaptic endocannabinoid-mediated long-term depression in LHb neurons. Moreover, ΔPKA mutation potentiates GABAA receptor-mediated inhibitory transmission while increasing LHb intrinsic excitability through suppression of medium afterhyperpolarizations. ΔPKA mutation-induced suppression of medium afterhyperpolarizations also blunts the synaptic and neuroexcitatory actions of the stress neuromodulator, corticotropin releasing factor (CRF), in mouse LHb. Altogether, our data suggest that AKAP150 complex signaling plays a critical role in regulation of AMPA and GABAA receptor synaptic strength, glutamatergic plasticity and CRF neuromodulation possibly through AMPA receptor and potassium channel trafficking and endocannabinoid signaling within the LHb.

Published
2024
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94. Exploring the support needs of Australian parents of young children with Usher syndrome: a qualitative thematic analysis

Author

L. Johansen, F. O’Hare, E. R. Shepard, L. N. Ayton, L. J. Pelentsov, L. S. Kearns, and K. L. Galvin

Subjects
Usher syndrome, Parents, Support needs, Interview study, Rare disease, Disease burden, Medicine
Abstract

Abstract Background Advancements in genetic testing have led to Usher syndrome now being diagnosed at a much earlier age than in the past, enabling the provision of early intervention and support to children and families. Despite these developments, anecdotal reports suggest there are substantial gaps in the services and supports provided to parents of children with Usher syndrome. The current study investigated the support needs of parents of children with Usher syndrome Type 1 when their child was aged 0 to 5 years. Method Purposive sampling was used, and six semi-structured interviews were conducted with Australian parents of children with Usher syndrome, Type 1. Data was analysed using modified reflexive thematic analysis. Results Four key themes were identified as being central to the support needs of parents of children with Usher syndrome aged 0 to 5 years. (1) Social Needs referred to parents’ need for various sources of social support, (2) Informational Needs described the lack of information parents received regarding Usher syndrome from treating professionals, (3) Practical Needs included supports needed to assist parents in managing the day-to-day tasks of caring for a child with a disability, and (4) Emotional Needs represented the emotional support (both formal and informal) that parents needed to be a positive support to their child. Conclusions Findings provide rich information for relevant support groups, policy makers, individual healthcare professionals, and professional governing bodies regarding the education of stakeholders and the development and implementation of best-practice treatment guidelines.

Published
2024
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95. MWC656: A Be+BH or a Be+sdO?

Author

Rivinius, Th., Klement, R., Chojnowski, S. D., Baade, D., Shepard, K., and Hadrava, P.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

MWC656 has been reported as classical Be star with a black hole companion. Revisited spectral variability properties render this unlikely, with a hot subdwarf more probable., Comment: To be published in IAUS361 proceedings

Published
2022

96. Double excitation energies from quantum Monte Carlo using state-specific energy optimization

Author

Shepard, Stuart, Panadés-Barrueta, Ramón Lorenzo, Moroni, Saverio, Scemama, Anthony, and Filippi, Claudia

Subjects
Physics - Computational Physics, Physics - Chemical Physics, Quantum Physics
Abstract

We show that recently developed quantum Monte Carlo methods, which provide accurate vertical transition energies for single excitations, also successfully treat double excitations. We study the double excitations in medium-sized molecules, some of which are challenging for high level coupled-cluster calculations to model accurately. Our fixed-node diffusion Monte Carlo excitation energies are in very good agreement with reliable benchmarks, when available, and provide accurate predictions for excitation energies of difficult systems where reference values are lacking.

Published
2022

97. Targeting deoxycytidine kinase improves symptoms in mouse models of multiple sclerosis

Author

Chen, Bao Ying, Salas, Jessica R, Trias, Alyssa O, Rodriguez, Arely Perez, Tsang, Jonathan E, Guemes, Miriam, Le, Thuc M, Galic, Zoran, Shepard, H Michael, Steinman, Lawrence, Nathanson, David A, Czernin, Johannes, Witte, Owen N, Radu, Caius G, Schultz, Kenneth A, and Clark, Peter M

Subjects
Biomedical and Clinical Sciences, Immunology, Autoimmune Disease, Neurodegenerative, Neurosciences, Brain Disorders, Multiple Sclerosis, 2.1 Biological and endogenous factors, Aetiology, Inflammatory and immune system, Neurological, Animals, Mice, Deoxycytidine Kinase, Encephalomyelitis, Autoimmune, Experimental, Lymphocytes, Disease Models, Animal, Mice, Inbred C57BL, autoimmunity, EAE, MS, imaging, nucleotide metabolism, EAE/MS, Paediatrics and Reproductive Medicine
Abstract

Multiple sclerosis (MS) is an autoimmune disease driven by lymphocyte activation against myelin autoantigens in the central nervous system leading to demyelination and neurodegeneration. The deoxyribonucleoside salvage pathway with the rate-limiting enzyme deoxycytidine kinase (dCK) captures extracellular deoxyribonucleosides for use in intracellular deoxyribonucleotide metabolism. Previous studies have shown that deoxyribonucleoside salvage activity is enriched in lymphocytes and required for early lymphocyte development. However, specific roles for the deoxyribonucleoside salvage pathway and dCK in autoimmune diseases such as MS are unknown. Here we demonstrate that dCK activity is necessary for the development of clinical symptoms in the MOG35-55 and MOG1-125 experimental autoimmune encephalomyelitis (EAE) mouse models of MS. During EAE disease, deoxyribonucleoside salvage activity is elevated in the spleen and lymph nodes. Targeting dCK with the small molecule dCK inhibitor TRE-515 limits disease severity when treatments are started at disease induction or when symptoms first appear. EAE mice treated with TRE-515 have significantly fewer infiltrating leukocytes in the spinal cord, and TRE-515 blocks activation-induced B and T cell proliferation and MOG35-55 -specific T cell expansion without affecting innate immune cells or naïve T and B cell populations. Our results demonstrate that targeting dCK limits symptoms in EAE mice and suggest that dCK activity is required for MOG35-55 -specific lymphocyte activation-induced proliferation.

Published
2023

98. A science-based agenda for health-protective chemical assessments and decisions: overview and consensus statement

Author

Woodruff, Tracey J, Rayasam, Swati DG, Axelrad, Daniel A, Koman, Patricia D, Chartres, Nicholas, Bennett, Deborah H, Birnbaum, Linda S, Brown, Phil, Carignan, Courtney C, Cooper, Courtney, Cranor, Carl F, Diamond, Miriam L, Franjevic, Shari, Gartner, Eve C, Hattis, Dale, Hauser, Russ, Heiger-Bernays, Wendy, Joglekar, Rashmi, Lam, Juleen, Levy, Jonathan I, MacRoy, Patrick M, Maffini, Maricel V, Marquez, Emily C, Morello-Frosch, Rachel, Nachman, Keeve E, Nielsen, Greylin H, Oksas, Catherine, Abrahamsson, Dimitri Panagopoulos, Patisaul, Heather B, Patton, Sharyle, Robinson, Joshua F, Rodgers, Kathryn M, Rossi, Mark S, Rudel, Ruthann A, Sass, Jennifer B, Sathyanarayana, Sheela, Schettler, Ted, Shaffer, Rachel M, Shamasunder, Bhavna, Shepard, Peggy M, Shrader-Frechette, Kristin, Solomon, Gina M, Subra, Wilma A, Vandenberg, Laura N, Varshavsky, Julia R, White, Roberta F, Zarker, Ken, and Zeise, Lauren

Subjects
Epidemiology, Public Health, Health Sciences, Patient Safety, Prevention, Aetiology, 2.2 Factors relating to the physical environment, Generic health relevance, Life on Land, Humans, Environmental Exposure, Environmental Health, Environmental Pollutants, Risk Assessment, Consensus Development Conferences as Topic, Chemicals, Conflicts of Interest, Environmental Justice, EPA, Hazard Identification, Health Equity, TSCA, Public Health and Health Services, Toxicology, Public health
Abstract

The manufacture and production of industrial chemicals continues to increase, with hundreds of thousands of chemicals and chemical mixtures used worldwide, leading to widespread population exposures and resultant health impacts. Low-wealth communities and communities of color often bear disproportionate burdens of exposure and impact; all compounded by regulatory delays to the detriment of public health. Multiple authoritative bodies and scientific consensus groups have called for actions to prevent harmful exposures via improved policy approaches. We worked across multiple disciplines to develop consensus recommendations for health-protective, scientific approaches to reduce harmful chemical exposures, which can be applied to current US policies governing industrial chemicals and environmental pollutants. This consensus identifies five principles and scientific recommendations for improving how agencies like the US Environmental Protection Agency (EPA) approach and conduct hazard and risk assessment and risk management analyses: (1) the financial burden of data generation for any given chemical on (or to be introduced to) the market should be on the chemical producers that benefit from their production and use; (2) lack of data does not equate to lack of hazard, exposure, or risk; (3) populations at greater risk, including those that are more susceptible or more highly exposed, must be better identified and protected to account for their real-world risks; (4) hazard and risk assessments should not assume existence of a "safe" or "no-risk" level of chemical exposure in the diverse general population; and (5) hazard and risk assessments must evaluate and account for financial conflicts of interest in the body of evidence. While many of these recommendations focus specifically on the EPA, they are general principles for environmental health that could be adopted by any agency or entity engaged in exposure, hazard, and risk assessment. We also detail recommendations for four priority areas in companion papers (exposure assessment methods, human variability assessment, methods for quantifying non-cancer health outcomes, and a framework for defining chemical classes). These recommendations constitute key steps for improved evidence-based environmental health decision-making and public health protection.

Published
2023

99. Current practice and recommendations for advancing how human variability and susceptibility are considered in chemical risk assessment

Author

Varshavsky, Julia R, Rayasam, Swati DG, Sass, Jennifer B, Axelrad, Daniel A, Cranor, Carl F, Hattis, Dale, Hauser, Russ, Koman, Patricia D, Marquez, Emily C, Morello-Frosch, Rachel, Oksas, Catherine, Patton, Sharyle, Robinson, Joshua F, Sathyanarayana, Sheela, Shepard, Peggy M, and Woodruff, Tracey J

Subjects
Clinical Research, Pediatric, Prevention, Pediatric Research Initiative, 2.2 Factors relating to the physical environment, 2.3 Psychological, social and economic factors, Aetiology, Generic health relevance, Life on Land, Infant, Child, Pregnancy, Female, Humans, Environmental Exposure, Risk Assessment, Poverty, Adjustment factors, Chemicals, Cumulative risk, Environmental justice, EPA, NAMs, Risk assessment, Susceptibility, Variability, Vulnerability, Public Health and Health Services, Toxicology
Abstract

A key element of risk assessment is accounting for the full range of variability in response to environmental exposures. Default dose-response methods typically assume a 10-fold difference in response to chemical exposures between average (healthy) and susceptible humans, despite evidence of wider variability. Experts and authoritative bodies support using advanced techniques to better account for human variability due to factors such as in utero or early life exposure and exposure to multiple environmental, social, and economic stressors.This review describes: 1) sources of human variability and susceptibility in dose-response assessment, 2) existing US frameworks for addressing response variability in risk assessment; 3) key scientific inadequacies necessitating updated methods; 4) improved approaches and opportunities for better use of science; and 5) specific and quantitative recommendations to address evidence and policy needs.Current default adjustment factors do not sufficiently capture human variability in dose-response and thus are inadequate to protect the entire population. Susceptible groups are not appropriately protected under current regulatory guidelines. Emerging tools and data sources that better account for human variability and susceptibility include probabilistic methods, genetically diverse in vivo and in vitro models, and the use of human data to capture underlying risk and/or assess combined effects from chemical and non-chemical stressors.We recommend using updated methods and data to improve consideration of human variability and susceptibility in risk assessment, including the use of increased default human variability factors and separate adjustment factors for capturing age/life stage of development and exposure to multiple chemical and non-chemical stressors. Updated methods would result in greater transparency and protection for susceptible groups, including children, infants, people who are pregnant or nursing, people with disabilities, and those burdened by additional environmental exposures and/or social factors such as poverty and racism.

Published
2023

100. 14.5 A 12nm Linux-SMP-Capable RISC-V SoC with 14 Accelerator Types, Distributed Hardware Power Management and Flexible NoC-Based Data Orchestration.

Author

Maico Cassel dos Santos, Tianyu Jia, Joseph Zuckerman, Martin Cochet, Davide Giri, Erik Jens Loscalzo, Karthik Swaminathan, Thierry Tambe, Jeff Jun Zhang, Alper Buyuktosunoglu, Kuan-Lin Chiu, Giuseppe Di Guglielmo, Paolo Mantovani, Luca Piccolboni, Gabriele Tombesi, David Trilla, John-David Wellman, En-Yu Yang, Aporva Amarnath, Ying Jing, Bakshree Mishra, Joshua Park, Vignesh Suresh, Sarita V. Adve, Pradip Bose, David Brooks 0001, Luca P. Carloni, Kenneth L. Shepard, and Gu-Yeon Wei

Published
2024
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