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517 results on '"Shimizu, Seiichi"'

59. Macroscopic Characteristics of the Native Liver in Children With MPV17 ‐Related Mitochondrial DNA Depletion Syndrome: An Indication for Performing Liver Transplantation?

Author

Kasahara, Mureo, primary, Sakamoto, Seisuke, additional, Fukuda, Akinari, additional, Horikawa, Reiko, additional, Ito, Reiko, additional, Uchida, Hajime, additional, Yanagi, Yusuke, additional, Shimizu, Seiichi, additional, Nakao, Toshimasa, additional, Mimori, Kotaro, additional, Haga, Chizuko, additional, Schlegel, Andrea, additional, Ohtake, Akira, additional, Shimura, Masaru, additional, Fushimi, Takuya, additional, Ichimoto, Keiko, additional, Matsunaga, Ayako, additional, and Murayama, Kei, additional

Published
2021
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62. Measurement of Proteasome Activity in Peripheral Blood Mononuclear Cells as an Indicator of Susceptibility to Bortezomib-Induced Severe Neurological Adverse Events in Patients with Multiple Myeloma

Author

Cho, Yukiko, Hori, Mitsuo, Okoshi, Yasushi, Fujisawa, Fumie, Shinagawa, Atsushi, Kudo, Daisuke, Komeno, Takuya, Yoshida, Chikashi, Katsura, Yukitaka, Ota, Ikuyo, Shimizu, Seiichi, Kamoshita, Masaharu, Sasaki, Katsuhiro, Tanaka, Keiji, Mukai, Harumi Y., and Kojima, Hiroshi

Published
2015
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65. Immunological features and complications in patients with glycogen storage disease 1b after living donor liver transplantation

Author

Shimizu, Seiichi, primary, Sakamoto, Seisuke, additional, Yamada, Masaki, additional, Fukuda, Akinari, additional, Yanagi, Yusuke, additional, Uchida, Hajime, additional, Mimori, Kotaro, additional, Shoji, Kensuke, additional, Funaki, Takanori, additional, Miyairi, Isao, additional, Nakano, Noriyuki, additional, Haga, Chizuko, additional, Yoshioka, Takako, additional, Imadome, Ken‐Ichi, additional, Horikawa, Reiko, additional, and Kasahara, Mureo, additional

Published
2021
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67. Adherence to the standard dose of imatinib, rather than dose adjustment based on its plasma concentration, is critical to achieve a deep molecular response in patients with chronic myeloid leukemia

Author

Yoshida, Chikashi, Komeno, Takuya, Hori, Mitsuo, Kimura, Tomofumi, Fujii, Masami, Okoshi, Yasushi, Suzukawa, Kazumi, Chiba, Shigeru, Hasegawa, Yuichi, Mukai, Harumi Yamamoto, Ito, Takayoshi, Shimizu, Seiichi, Kamoshita, Masaharu, Kudo, Daisuke, Shinagawa, Atsushi, Chikatsu, Norio, Monma, Yuriko, Watanabe, Norimichi, and Kojima, Hiroshi

Published
2011
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69. Early Dynamics of Chronic Myeloid Leukemia on Nilotinib Predicts Deep Molecular Response

Author

Okamoto, Yuji, primary, Hirano, Mitsuhito, additional, Morino, Kai, additional, Kajita, Masashi K., additional, Nakaoka, Shinji, additional, Tsuda, Mayuko, additional, Sugimoto, Kei-ji, additional, Tamaki, Shigehisa, additional, Hisatake, Junichi, additional, Yokoyama, Hisayuki, additional, Igarashi, Tadahiko, additional, Shinagawa, Atsushi, additional, Sugawara, Takeaki, additional, Hara, Satoru, additional, Fujikawa, Kazuhisa, additional, Shimizu, Seiichi, additional, Yujiri, Toshiaki, additional, Wakita, Hisashi, additional, Nishiwaki, Kaichi, additional, Tojo, Arinobu, additional, and Aihara, Kazuyuki, additional

Published
2021
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72. Fatal Epstein‐Barr virus‐associated hemophagocytic lymphohistiocytosis with virus‐infected T cells after pediatric multivisceral transplantation: A proof‐of‐concept case report

Author

Yamada, Masaki, primary, Sakamoto, Seisuke, additional, Sakamoto, Kenichi, additional, Uchida, Hajime, additional, Shimizu, Seiichi, additional, Osumi, Tomoo, additional, Kato, Motohiro, additional, Shoji, Kensuke, additional, Arai, Katsuhiro, additional, Miyazaki, Osamu, additional, Nakano, Noriyuki, additional, Yoshioka, Takako, additional, Fukuda, Akinari, additional, Kasahara, Mureo, additional, and Imadome, Ken‐Ichi, additional

Published
2020
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77. Surgical technique and the long‐term outcomes of pediatric living donor domino liver transplantation from patients with maple syrup urine disease.

Author

Shimizu, Seiichi, Sakamoto, Seisuke, Fukuda, Akinari, Yanagi, Yusuke, Uchida, Hajime, Mimori, Kotaro, Nakao, Toshimasa, Sun, Chao, Horikawa, Reiko, and Kasahara, Mureo

Subjects
*URINALYSIS, *LIVER transplantation, *OPERATIVE surgery, *PROTEIN C, *BILIARY atresia, *TRANSPLANTATION of organs, tissues, etc.
Abstract

Background: The native liver of patients with maple syrup urine disease (MSUD) (1st recipients) can be used as a graft for non‐MSUD patients with end‐stage liver disease (2nd recipients). This study aimed to demonstrate the optimal operational procedures and the long‐term outcomes of 2nd recipients. Methods: Six 2nd recipients of living donor domino liver transplantation (LD‐DLT) (age: 42.5 [22–169] months at DLT) received a native liver as a graft from an MSUD patient at our hospital between June 2014 and April 2020. We reviewed the operational procedures and outcomes of 2nd recipients after LD‐DLT. Results: The 2nd recipients' original diseases included biliary atresia, congenital hepatic fibrosis, congenital protein C deficiency, familial hypercholesterolemia, hepatoblastoma, and mitochondrial hepatopathy. Five of the six recipients had a whole liver and one had a right lobe graft. The site at which the vessels of the MSUD liver were dissected prioritized the safety of the 1st recipient. At the end of follow‐up, all recipients were doing well without surgical complications. The mean serum amino acid values of the 2nd recipients did not exceed the upper limit of the reference values during the long‐term observation period. All patients showed normal growth while maintaining the same z‐score of height and weight after LD‐DLT as the preoperative level. Conclusion: The liver of patients with MSUD can be used safely without concern regarding long‐term complications or de novo MSUD development. LD‐DLT using the MSUD liver can expand the donor pool as an alternative graft in pediatric LT. [ABSTRACT FROM AUTHOR]

Published
2022
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78. Macroscopic Characteristics of the Native Liver in Children With MPV17‐Related Mitochondrial DNA Depletion Syndrome: An Indication for Performing Liver Transplantation?

Author

Kasahara, Mureo, Sakamoto, Seisuke, Fukuda, Akinari, Horikawa, Reiko, Ito, Reiko, Uchida, Hajime, Yanagi, Yusuke, Shimizu, Seiichi, Nakao, Toshimasa, Mimori, Kotaro, Haga, Chizuko, Schlegel, Andrea, Ohtake, Akira, Shimura, Masaru, Fushimi, Takuya, Ichimoto, Keiko, Matsunaga, Ayako, and Murayama, Kei

Published
2022
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87. Optimal treatment strategy with nilotinib for patients with newly diagnosed chronic‐phase chronic myeloid leukemia based on early achievement of deep molecular response (MR 4.5 ): The phase 2, multicenter N‐Road study

Author

Nishiwaki, Kaichi, primary, Sugimoto, Kei‐ji, additional, Tamaki, Shigehisa, additional, Hisatake, Junichi, additional, Yokoyama, Hisayuki, additional, Igarashi, Tadahiko, additional, Shinagawa, Atsushi, additional, Sugawara, Takeaki, additional, Hara, Satoru, additional, Fujikawa, Kazuhisa, additional, Shimizu, Seiichi, additional, Yujiri, Toshiaki, additional, Tojo, Arinobu, additional, and Wakita, Hisashi, additional

Published
2020
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90. Hepatic epithelioid hemangioendothelioma successfully treated with living donor liver transplantation: A case report and literature review

Author

Fukuhara, Sotaro, primary, Tahara, Hiroyuki, additional, Hirata, Yoshito, additional, Ono, Kosuke, additional, Hamaoka, Michinori, additional, Shimizu, Seiichi, additional, Hashimoto, Shinji, additional, Kuroda, Shintaro, additional, Ohira, Masahiro, additional, Ide, Kentaro, additional, Kobayashi, Tsuyoshi, additional, and Ohdan, Hideki, additional

Published
2019
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92. The extracorporeal circulation with transdiaphragmatic approach in living‐donor liver transplantation for HB with atrial extension of tumor thrombus: A case report.

Author

Shimizu, Seiichi, Sakamoto, Seisuke, Fukuda, Akinari, Yanagi, Yusuke, Uchida, Hajime, Baba, Chiaki, Suzuki, Yasuyuki, Kondo, Ryoichi, Kaneko, Yukihiro, Nakano, Noriyuki, Haga, Chizuko, Yoshioka, Takako, Matsumoto, Kimikazu, and Kasahara, Mureo

Subjects
*ARTIFICIAL blood circulation, *LIVER transplantation, *OPERATIVE surgery, *THROMBOSIS, *LIVER tumors, *HEPATOCELLULAR carcinoma
Abstract

Surgical intervention for HB with tumor thrombi extending into the IVC and the RA might requires careful planning of the surgical procedures, including vascular reconstruction and extracorporeal circulation. We herein report a successful case of LDLT for HB with atrial extension of a tumor thrombus by extracorporeal circulation with a transdiaphragmatic approach. The patient was a 5‐year‐old boy with PRETEXT IV HB with a tumor thrombus that extended into the IVC and the RA. After 4 cycles of chemotherapy and resection of bilateral lung metastases, the size of the primary HB tumor decreased. As the tumor extension from the LHV to the RA had decreased but was still present, we performed LDLT with tumor thrombectomy. The central part of the diaphragm was sagittally incised to expose the suprahepatic IVC and the RA. Venovenous bypass was achieved from the right femoral vein and IMV to the RA En bloc resection of the native liver with the tumor thrombus was then performed. HV anastomosis was made between the newly created orifice on the IVC and the graft LHV. The duration of LDLT was 10 hours and 44 minutes (extracorporeal circulation time: 78 minutes). Pediatric LT for HB with the extension of tumor thrombi into the RA under extracorporeal circulation is a feasible option and allows for the expansion of the indications for transplantation for children with unresectable liver tumors. [ABSTRACT FROM AUTHOR]

Published
2021
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93. Current status of pediatric deceased donor liver transplantation: Lessons learned from a high‐volume center in Japan where living donation remains predominant.

Author

Sakamoto, Seisuke, Uchida, Hajime, Shimizu, Seiichi, Yanagi, Yusuke, Takeda, Masahiro, Kubota, Tomomi, Nakazato, Yayoi, Fukuda, Akinari, and Kasahara, Mureo

Abstract

Background: In Japan, a recent gradual increase in deceased donor donation has expanded opportunities for pediatric patients to obtain deceased grafts. Methods: Forty‐three children underwent deceased donor liver transplantation (DDLT) at our institute before February 2020. Twenty‐five patients received a split or reduced graft and 18 patients received a whole graft. The clinical outcomes of DDLT were retrospectively analyzed. Results: The main organ resource was split/reduced grafts retrieved from adult donors; however, the number of whole grafts retrieved from pediatric donors has increased. The rates of major complications were similar in the two groups. The 5‐year graft survival rate of patients who received a split/reduced graft (78.0%) was lower than that of patients who received a whole graft (88.9%; P =.40). The 3‐year graft survival rates of patients who recently received a split/reduced graft and a whole graft improved to 92.3% and 91.7%, respectively. Conclusions: The recent amendment of the organ allocation system, especially the introduction of pediatric prioritization, can effectively increase the chance to obtain deceased donor grafts for pediatric DDLT in Japan. The recent refinements in donor and recipient selection and in the surgical technique of split DDLT can improve the outcomes of pediatric DDLT in Japan. [ABSTRACT FROM AUTHOR]

Published
2021
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98. Impact of sarcopenia in infants with liver transplantation for biliary atresia.

Author

Takeda, Masahiro, Sakamoto, Seisuke, Uchida, Hajime, Shimizu, Seiichi, Yanagi, Yusuke, Fukuda, Akinari, Nosaka, Shunsuke, and Kasahara, Mureo

Subjects
BILIARY atresia, SARCOPENIA, LIVER transplantation, COMPUTED tomography, INFANTS, CHOLANGIOGRAPHY, TRANSPLANTATION of organs, tissues, etc.
Abstract

While sarcopenia is an important predictor of LT outcomes in adults, few studies have examined the association of sarcopenia with LT outcomes in pediatric patients. We investigated the clinical influence of sarcopenia on the post‐transplant outcomes in infants with BA. To define sarcopenia in infants, the cross‐sectional area of the tPMA in 93 healthy control infants was measured by computed tomography. Sarcopenia was defined as a tPMA lower than two standard deviations below the mean of healthy control infants. Eighty‐nine infants with BA with a median age at LT of 7.6 months old were enrolled. The clinical characteristics and outcomes of LT were verified in the sarcopenia group (n = 21) and non‐sarcopenia group (n = 68). The sarcopenia group had a significantly longer operation time and greater blood loss during LT than the non‐sarcopenia group (P =.03 and 0.02). The incidence of portal vein stenosis and post‐operative bloodstream infection was also significantly higher in the sarcopenia group than in the non‐sarcopenia group (23.8% vs 4.4%, P =.02 and 28.6% vs 10.3%, P =.04, respectively). The total length of hospital stay did not differ significantly. The 1‐year patient and graft survival rates tended to be lower in the sarcopenia group than in the non‐sarcopenia group (90.5% vs 98.5%, P =.07 and 85.7% vs 97.1%, P =.05, respectively). Sarcopenia in infants with BA may be associated with the patient survival and serve as an effective marker for post‐operative outcomes of LT. [ABSTRACT FROM AUTHOR]

Published
2021
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100. Outcomes of 50 Cases of Pediatric Liver Transplantation for Intrapulmonary Shunt While Considering the Deteriorated Prognosis of Severe Intrapulmonary Shunt Patients

Author

Hirata, Yoshihiro, primary, Sakamoto, Seisuke, additional, Yoshimura, Shohei, additional, Takeda, Masahiro, additional, Uchida, Hajime, additional, Shimizu, Seiichi, additional, Kitamura, Masayuki, additional, Irie, Rie, additional, Miyazaki, Osamu, additional, Yoshioka, Takako, additional, Nosaka, Syunsuke, additional, and Kasahara, Mureo, additional

Published
2019
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