828 results on '"Shun Wan"'
Search Results
52. Analysis of a variational Bayesian adaptive cubature Kalman filter tracking loop for high dynamic conditions
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Miao, Zhi-yong, Lv, Yun-long, Xu, Ding-jie, Shen, Feng, and Pang, Shun-wan
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- 2017
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53. Meet the Editorial Board Member
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Shun-Wan Chan
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Complementary and alternative medicine ,Drug Discovery - Published
- 2022
54. Enhanced Mechanical Stability and Proton Conductivity Performance from the Dense Mn(II)-Metal-Organic Framework to Porous Mn(II)-Fe(III)-Metal-Organic Framework
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Zi-You Zhang, Guo-Xu Qin, Xiao-Min Li, Hong-Liang Dong, Shun Wan, Yong-Hong Ni, Jiang Liu, Zhi-Qiang Chen, and Zhi Su
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Inorganic Chemistry ,Physical and Theoretical Chemistry - Abstract
Postsynthetic modification (PSM) of the metal-organic framework (MOF) has been demonstrated to be an effective strategy to enhance performance. In this particular work, the anion framework
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- 2022
55. Topologically Enabled Ultrahigh-Q Chiroptical Resonances by Merging Bound States in the Continuum
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Shun Wan, Keda Wang, Fatian Wang, Chunying Guan, Wenjia Li, Jianlong Liu, Andrey Bogdanov, Pavel A. Belov, and Jinhui Shi
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Atomic and Molecular Physics, and Optics - Abstract
Ultrahigh-Q chiroptical resonance metasurfaces based on merging bound states in the continuum (BICs) are investigated and numerically demonstrated. The destruction of C2 symmetry results in the leakage of BICs into quasi-BICs, and a chiral quasi-BIC is obtained by oblique incidence or continuous destruction of the mirror symmetry of the structure. Due to the significant topological properties of merging BICs, the Q factor (over 2 × 105) of the chiral resonance peak obtained is much higher than that of the previous work. Moreover, the proposed structure is easy to fabricate because no additional out-of-plane asymmetry is introduced. The proposed scheme is of importance in chiral biosensing applications.
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- 2022
56. Evolution of Structural and Electronic Properties in NbTe2 under High Pressure
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Yanju Wang, Shun Wan, Nana Li, Hongliang Dong, Wen Deng, Resta A. Susilo, Bin Chen, Mingqiang Hou, Chunxiao Gao, Qing Dong, Shujia Li, and Jiajia Feng
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Phase transition ,Condensed matter physics ,Field (physics) ,Electronic correlation ,010405 organic chemistry ,Chemistry ,Stacking ,Electron ,010402 general chemistry ,01 natural sciences ,0104 chemical sciences ,Inorganic Chemistry ,Transition metal ,Condensed Matter::Strongly Correlated Electrons ,Charge carrier ,Physical and Theoretical Chemistry ,Charge density wave - Abstract
Transition metal dichalcogenides (TMDs) have attracted wide attention due to their quasi-two-dimensional layered structure and exotic properties. Plenty of efforts have been done to modulate the interlayer stacking manner for novel states. However, as an equally important element in shaping the unique properties of TMDs, the effect of intralayer interaction is rarely revealed. Here, we report a particular case of pressure-tuned re-arrangement of intralayer atoms in distorted 1T-NbTe2, which was demonstrated to be a new type of structural phase transition in TMDs. The structural transition occurs in the pressure range of 16-20 GPa, resulting in a transformation of Nb atomic arrangement from the trimeric to dimeric structure, accompanied by a dramatic collapse of unit cell volume and lattice parameters. Simultaneously, a charge density wave (CDW) was also found to collapse during the phase transition. The strong increase in the critical fluctuations of CDW induces a significant decline in the electronic correlation and a change of charge carrier type from hole to electron in NbTe2. Our finding reveals a new mechanism of structure evolution and expands the field of pressure-induced phase transition.
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- 2021
57. Grain-size gradient structure by abnormal grain growth
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Bin Chen, Hongliang Dong, Junpu Wang, Zhiqiang Chen, Jinling Liu, He Li, Shun Wan, Haikuo Wang, Mingzhi Yuan, Duanwei He, and Resta A. Susilo
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Materials science ,Sintering ,chemistry.chemical_element ,02 engineering and technology ,Abnormal grain growth ,Tungsten ,Pole figure ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Grain size ,0104 chemical sciences ,Shear modulus ,chemistry ,General Materials Science ,Crystallite ,Composite material ,0210 nano-technology ,Ductility - Abstract
We report a novel method to synthesize bulk grain-size gradient polycrystalline Ni by AGG. By periodical sintering in the large volume press (LVP), AGG repeatedly occurs, resulting in exceptionally large grains on the sample surface, but the inner grains are still small. The formation of grain-size gradient profile is attributed to the uneven plastic deformation caused by compression in the LVP. Besides, the gradient structure can be achievable with uniformity by employing tungsten with a high shear modulus into the sample assembly. This work would guide us to design bulk heterogeneous gradient nanostructured materials with both excellent strength and ductility. The uniform grained gradient structure obtained with the improved LVP assembly. (a) The improved LVP assembly with W tablet used between Ni sample and outer Mo-capsule; (b) Inverse pole figure mapping characterization of uniform grain-size gradient structure comprised of smaller grains.
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- 2021
58. Epigallocatechin gallate modulates ferroptosis through downregulation of tsRNA-13502 in non-small cell lung cancer
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Shun Wang, Ruohuang Wang, Dingtao Hu, Caoxu Zhang, Peng Cao, Jie Huang, and Baoqing Wang
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Epigallocatechin gallate (EGCG) ,Ferroptosis ,tsRNA ,NSCLC ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 ,Cytology ,QH573-671 - Abstract
Abstract Ferroptosis, an iron-dependent regulated cell death mechanism, holds significant promise as a therapeutic strategy in oncology. In the current study, we explored the regulatory effects of epigallocatechin gallate (EGCG), a prominent polyphenol in green tea, on ferroptosis and its potential therapeutic implications for non-small cell lung cancer (NSCLC). Treatment of NSCLC cell lines with varying concentrations of EGCG resulted in a notable suppression of cell proliferation, as evidenced by a reduction in Ki67 immunofluorescence staining. Western blot analyses demonstrated that EGCG treatment led to a decrease in the expression of glutathione peroxidase 4 (GPX4) and solute carrier family 7 member 11 (SLC7A11) while increasing the levels of acyl-CoA synthetase long-chain family member 4 (ACSL4). These molecular changes were accompanied by an increase in intracellular iron, malondialdehyde (MDA), and reactive oxygen species (ROS), alongside ultrastructural alterations characteristic of ferroptosis. Through small RNA sequencing and RT-qPCR, transfer RNA-derived small RNA 13502 (tsRNA-13502) was identified as a significant target of EGCG action, with its expression being upregulated in NSCLC tissues compared to adjacent non-tumorous tissues. EGCG was found to modulate the ferroptosis pathway by downregulating tsRNA-13502 and altering the expression of key ferroptosis regulators (GPX4/SLC7A11 and ACSL4), thereby promoting the accumulation of iron, MDA, and ROS, and ultimately inducing ferroptosis in NSCLC cells. This study elucidates EGCG’s multifaceted mechanisms of action, underscoring the modulation of ferroptosis as a viable therapeutic approach for enhancing NSCLC treatment outcomes.
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- 2024
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59. Do not stumble over the same 'stone' twice: a case series of endogenous endophthalmitis secondary to severe systemic diseases
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Ying He, Weijuan Zeng, Wenjian Shi, Xiaomin Chen, Yanru Shen, Shun Wang, Xiaojun Cai, Yang Liu, Yingying Gao, and Min Ke
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Endogenous endophthalmitis ,C. Albicans ,K. pneumoniae ,Holmium:YAG laser lithotripsy ,Pregnancy ,Invasive liver abscess syndrome ,Ophthalmology ,RE1-994 - Abstract
Abstract Background Endogenous endophthalmitis (EE) is a rare but highly destructive eye emergency secondary to systemic infection. Acute endophthalmitis can lead to irreversible vision impairment or even loss of the whole eye, unless being diagnosed and treated promptly. Case presentation This study reports three typical EE cases of endogenous endophthalmitis secondary to different severe systemic diseases. Patients were recruited from the Department of ophthalmology at Zhongnan hospital of Wuhan University and the Department of ophthalmology at the Second Affiliated Hospital of Fujian Medical University. Patients were followed up for up to 60 days. Among these cases, the eye symptoms is the initial manifestations while secondary to original different special systemic conditions. Patients have been treated under dynamically prompt response undergoing systemic treatment and eye treatment at the same time. Best corrected visual acuity were 20/40, 20/60 and light perception during follow-up evaluation. Conclusions Our observation suggest that prompt identification and treatment could save patients’ vision from EE.
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- 2024
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60. Cholesterol lowering and vascular protective effects of ethanolic extract of dried fruit of Crataegus pinnatifida, hawthorn (Shan Zha), in diet-induced hypercholesterolaemic rat model
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Kwok, Ching-Yee, Li, Chang, Cheng, Huan-Le, Ng, Yam-Fung, Chan, Tak-Yi, Kwan, Yiu-Wa, Leung, George Pak-Heng, Lee, Simon Ming-Yuen, Mok, Daniel Kam-Wah, Yu, Peter Hoi-Fu, and Chan, Shun-Wan
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- 2013
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61. Suppression of diet-induced hypercholesterolaemia by saponins from Panax notoginseng in rats
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Wu, Jian-Hong, Leung, George Pak-Heng, Kwan, Yiu-Wa, Sham, Tung-Ting, Tang, Jing-Yi, Wang, You-Hua, Wan, Jian-Bo, Lee, Simon Ming-Yuen, and Chan, Shun-Wan
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- 2013
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62. Gui-ling-gao (turtle jelly), a traditional Chinese functional food, exerts anti-inflammatory effects by inhibiting iNOS and pro-inflammatory cytokine expressions in splenocytes isolated from BALB/c mice
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Zhang, Huan, Wu, Min-Yi, Guo, De-Jian, Wan, Chun-Wai, Lau, Ching-Ching, Chan, Chi-On, Mok, Daniel Kam-Wah, and Chan, Shun-Wan
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- 2013
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63. High-pressure synthesis and performance analysis of WC-cBN-MoS2 self-lubricating ceramic composites
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Jiakun Wu, Haikuo Wang, Zhicai Zhang, Chao Wang, Zhiqiang Hou, Shun Wan, Dazhuan Wu, and Xiaoping Ouyang
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General Medicine - Published
- 2023
64. Highly C2/C1-Selective Covalent Organic Frameworks Substituted with Azo Groups
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Shun Wan, Shaofeng Huang, Wei Zhang, Sadegh Yazdi, Li-Li Tan, Yiming Hu, and Yinghua Jin
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Materials science ,010405 organic chemistry ,Imine ,010402 general chemistry ,01 natural sciences ,0104 chemical sciences ,Crystallinity ,chemistry.chemical_compound ,Adsorption ,chemistry ,Covalent bond ,Polymer chemistry ,Molecule ,General Materials Science ,Gas separation ,Selectivity ,Covalent organic framework - Abstract
A series of covalent organic frameworks substituted with azo groups (AzoCOFs) have been synthesized via imine condensation. The obtained frameworks show crystallinity and high stability. More importantly, the AzoCOFs exhibit exceptionally high ideal adsorption solution theory (IAST) selectivity in adsorption of C2H2 (35-2891) over CH4 at 273 K and 1 bar, owing to the favorable interactions between azo groups and acetylene molecules. The dependence of the gas adsorption property on pore size and polarity of the frameworks was also studied. The triethylene glycol substituted Tg-AzoCOF shows the highest C2H2/CH4 selectivity (IAST selectivity of 2891), which represents the highest reported for all porous materials. The AzoCOFs also exhibit high IAST adsorption selectivity of C2H4/CH4 (11-20), C2H6/CH4 (15-22), and CO2/CH4 (12-37), which is comparable with most porous materials, thus showing their great potential in gas separation applications.
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- 2020
65. Superconductivity in In
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Jiapeng, Zhen, Wen, Deng, Cong, Li, Jiajia, Feng, Shihui, Zhang, Shun, Wan, Gui, Wang, Hongliang, Dong, Resta A, Susilo, and Bin, Chen
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Indium telluride (In
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- 2022
66. Key properties of inorganic thermoelectric materials-tables (version 1)
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Robert Freer, Dursun Ekren, Tanmoy Ghosh, Kanishka Biswas, Pengfei Qiu, Shun Wan, Lidong Chen, Shen Han, Chenguang Fu, Tiejun Zhu, A K M Ashiquzzaman Shawon, Alexandra Zevalkink, Kazuki Imasato, G. Jeffrey Snyder, Melis Ozen, Kivanc Saglik, Umut Aydemir, Raúl Cardoso-Gil, E Svanidze, Ryoji Funahashi, Anthony V Powell, Shriparna Mukherjee, Sahil Tippireddy, Paz Vaqueiro, Franck Gascoin, Theodora Kyratsi, Philipp Sauerschnig, Takao Mori, Mühendislik ve Doğa Bilimleri Fakültesi -- Metalurji ve Malzeme Mühendisliği Bölümü, Ekren, Dursun, Aydemir, Umut (ORCID 0000-0003-1164-1973 & YÖK ID 58403), Sağlık, Kıvanç, Özen, Melis, Freer, R., Ekren, D., Ghosh, T., Biswas, K., Qiu, P., Wan, S., Chen, L., Han, S., Fu, C., Zhu, T., Ashiquzzaman Shawon, A.K.M., Zevalkink, A., Imasato, K., Snyder, G.J., Cardoso-Gil, R., Svanidze, E., Funahashi, R., Powell, A.V., Mukherjee, S., Tippireddy, S., Vaqueiro, P., Gascoin, F., Kyratsi, T., Sauerschnig, P., Mori, T., Koç University Boron and Advanced Materials Application and Research Center (KUBAM) / Koç Üniversitesi Bor ve İleri Malzemeler Uygulama ve Araştırma Merkezi (KUBAM), Graduate School of Sciences and Engineering, College of Sciences, Department of Materials Science and Engineering, and Department of Chemistry
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Silicides ,Materials Science (miscellaneous) ,Physics - Thermoelectric Materials - Thermoelectric Properties ,Performance ,Antimony compounds ,Thermoelectric equipment ,Selenium compounds ,Compilation ,Data ,Thermoelectric ,Tellurium compounds ,Germanium compounds ,vııı clathrate ba8ga16sn30 ,P-type pbse ,Arsenic compounds ,Skutterudites ,Materials Chemistry ,Phonon ,Half-heusler compounds ,Higher manganese silicides ,Magnesium compounds ,Sulfur compounds ,Inorganic materials ,Thermo-Electric materials ,Enhanced mechanical stability ,Property ,Thermoelectricity ,Figure-of-merit ,General Energy ,Filled skutterudite antimonides ,Thermoelectric material ,Thermoelectric properties ,Hole Concentration ,Temperature transport-properties ,Thermoelectric conversion efficiency ,Energy and fuels ,Materials science ,Carbides ,Carrier scattering mechanism ,Inorganics ,Lead Selenides ,Ultralow thermal-conductivity ,Chalcogenides - Abstract
This paper presents tables of key thermoelectric properties, which define thermoelectric conversion efficiency, for a wide range of inorganic materials. The twelve families of materials included in these tables are primarily selected on the basis of well established, internationally-recognized performance and promise for current and future applications: tellurides, skutterudites, half Heuslers, Zintls, Mg-Sb antimonides, clathrates, FeGa3-type materials, actinides and lanthanides, oxides, sulfides, selenides, silicides, borides and carbides. As thermoelectric properties vary with temperature, data are presented at room temperature to enable ready comparison, and also at a higher temperature appropriate to peak performance. An individual table of data and commentary are provided for each family of materials plus source references for all the data., National Science Foundation; UK Engineering and Physical Sciences Research Council (EPSRC)
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- 2022
67. Danshensu is the major marker for the antioxidant and vasorelaxation effects of Danshen (Salvia miltiorrhiza) water-extracts produced by different heat water-extractions
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Zhou, Xuelin, Chan, Shun Wan, Tseng, Hui Ling, Deng, Yan, Hoi, Pui Man, Choi, Pou Seng, Or, Penelope M.Y., Yang, Jia-ming, Lam, Francis F.Y., Lee, Simon Ming Yuen, Leung, George Pak Heng, Kong, Siu Kai, Ho, Ho Pui, Kwan, Yiu Wa, and Yeung, John H.K.
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- 2012
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68. Preparation of a novel fluoride-containing carbon nanosphere by high-temperature carbonization method for enhancing fluororubber's mechanical and thermal degradation performance
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Yurou Chen, Yili Wei, Tiantian Wei, Yungang Sun, Zhukang Bai, Junchang Gao, Jun Li, Shun Wang, Yadong Wu, and Huile Jin
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Fluororubbr ,Fluorine-containing carbon nanospheres ,Mechanical property ,Thermal property ,Thermal degradation ,Polymers and polymer manufacture ,TP1080-1185 - Abstract
In this study, a novel fluorine-containing carbon nanosphere was synthesized by high-temperature carbonization of waste fluororubber trimmings, and its mixing method with fluororubber was investigated. It was found that the solution mixing method resulted in the highest tensile strength (7.6 %) and modulus at 100 % strain (13.3 %) of fluororubber compared to the mechanical mixing method. Furthermore, the addition of fluorine-containing carbon nanosphere can significantly enhance fluororubber's heat resistance, inhibit its thermal degradation, and increase its ultimate service temperature (266.3 °C, 2 years). This work provides new insights into the preparation of high-performance fluororubber composites.
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- 2024
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69. The effect of perineural dexamethasone on nerve injury and recovery of nerve function after surgery: A randomized controlled trial
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Na Zhu, Bingbing Xiang, Jinghong Shi, Pingliang Yang, Yunke Dai, and Shun Wang
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Perineural dexamethasone ,Nerve injury ,Nerve function ,Orthopedic surgery ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Background: While numerous studies have examined the influence of perineural dexamethasone on nerve block duration, its potential impact on postoperative nerve injury has not been adequately addressed. Objective: This study aims to elucidate the effect of perineural dexamethasone on nerve injury and nerve function recovery after surgery. Design: A prospective randomized double-blinded trial. Setting: The First Affiliated Hospital of Chengdu Medical College, Chengdu, China. The study was conducted between 14 June and 30 December 2022. Participants: Patients aged 18 – 80 years, ASA I - II, scheduled for elective orthopedic or burn and plastic surgery. Interventions: Patients were randomized to receive either perineural dexamethasone (D group) or no dexamethasone (ND group). Main outcome measures: Primary outcomes were the incidence and recovery of nerve injury. Secondary outcomes included postoperative pain scores, analgesic consumption, and adverse events. Results: Initial postoperative nerve injury rates were similar between groups (D: 30.4 %, ND: 33.3 %, P > 0.05). At 12 weeks post-discharge, significantly more patients in the ND group recovered from nerve deficits (78.8 % vs 60.3 %; OR = 2.45, 95 % CI = 1.05 – 5.72, P
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- 2024
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70. Neuroinflammation in Parkinson’s disease: focus on the relationship between miRNAs and microglia
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Ke Xu, Yuan Li, Yan Zhou, Yu Zhang, Yue Shi, Chengguang Zhang, Yan Bai, and Shun Wang
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neuroinflammation ,Parkinson’s disease (PD) ,microRNA (miRNA) ,microglia ,neurodegenerative diseases ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Parkinson’s disease (PD) is a prevalent neurodegenerative disorder that affects the central nervous system (CNS). Neuroinflammation is a crucial factor in the pathological advancement of PD. PD is characterized by the presence of activated microglia and increased levels of proinflammatory factors, which play a crucial role in its pathology. During the immune response of PD, microglia regulation is significantly influenced by microRNA (miRNA). The excessive activation of microglia, persistent neuroinflammation, and abnormal polarization of macrophages in the brain can be attributed to the dysregulation of certain miRNAs. Additionally, there are miRNAs that possess the ability to inhibit neuroinflammation. miRNAs, which are small non-coding epigenetic regulators, have the ability to modulate microglial activity in both normal and abnormal conditions. They also have a significant impact on promoting communication between neurons and microglia.
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- 2024
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71. Fluororubber composites: Preparation methods, vulcanization mechanisms, and the associated properties
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Yurou Chen, Yadong Wu, Jun Li, Xuqiang Peng, Shun Wang, Jichang Wang, and Huile Jin
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Infrared (IR) spectroscopy ,Mechanical properties ,Polymer-matrix composites (PMCs) ,Scanning electron microscopy (SEM) ,Thermal properties ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
Fluororubber (FKM) is an irreplaceable sealing material that plays a critical role in new energy vehicles, petrochemical and aerospace industries. Their broad applications arise from the excellent thermal stability and solvent resistance of fluororubber. Despite there are increasing number of reports on preparation methods, properties and characterization of FKM in literature, there is still a lack of a thorough and comprehensive review that summarizes these results. This paper provides an overview of FKM types, preparation methods, property testing and microscopic characterization, and attempts to give a comprehensive introduction to the vulcanization mechanism of FKM using ternary fluororubber. The mechanical mixing method was identified as the most versatile preparation method in the review, but it is susceptible to causing agglomeration of nanomaterials. Furthermore, different vulcanization systems and reinforcing fillers can be chosen based on the application direction of FKM. Carbon nanomaterials with high inherent strength have the best reinforcing effect on FKM, although they also exhibit the most significant self-agglomeration effect. This can be mitigated through synergistic use of fillers of multiple dimensions and interfacial modification in future research. Additionally, current challenges and future prospects for FKM nanocomposites are also discussed.
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- 2024
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72. High-pressure synthesis of high-performance submicron-sized polycrystalline β-Si3N4 bulk without additives
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Xudong Song, Xiaomiao Zhao, Shun Wan, Ya-nan Yang, Mengya Shang, Haikuo Wang, Hou Zhiqiang, Bin Chen, and Shuaipeng Chen
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010302 applied physics ,Materials science ,Process Chemistry and Technology ,02 engineering and technology ,021001 nanoscience & nanotechnology ,01 natural sciences ,Grain size ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Fracture toughness ,High pressure ,Bulk samples ,Phase (matter) ,0103 physical sciences ,Vickers hardness test ,Materials Chemistry ,Ceramics and Composites ,Crystallite ,Composite material ,0210 nano-technology ,Single crystal - Abstract
Dense and submicron-sized polycrystalline β-Si3N4 bulk samples with average grain size of 263 ± 68 nm have been synthesized using micron-sized α-Si3N4 powder (2 μm) as the starting material by simultaneously tuning the pressure and temperature conditions. The measured Vickers hardness HV of the submicron-sized polycrystalline β-Si3N4 could reach up to about 20 GPa, approaching the upper limit of the single crystal β-Si3N4. The measured fracture toughness KIC of the polycrystalline β-Si3N4 has been enhanced from 3.0 to 4.1 MPa m1/2, as much as 36%, while without sacrificing the hardness. This study demonstrates that using micron-sized powder as the starting material to synthesize submicron-sized polycrystalline bulks by phase transformation under extreme pressure conditions is an efficient pathway to break through the old paradigm—the higher the fracture toughness of a material, the lower the hardness.
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- 2020
73. Air Quality Index, Indicatory Air Pollutants and Impact of COVID-19 Event on the Air Quality near Central China
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Jiajia Zhang, Ya-Fen Wang, Kaijie Xu, Li-Hao Young, Kangping Cui, Shun Wan, and Yen Kung Hsieh
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Pollutant ,2019-20 coronavirus outbreak ,010504 meteorology & atmospheric sciences ,Coronavirus disease 2019 (COVID-19) ,Central china ,01 natural sciences ,Pollution ,Ambient air ,Toxicology ,Summer season ,Air pollutants ,Environmental Chemistry ,Environmental science ,Air quality index ,0105 earth and related environmental sciences - Abstract
Both the air quality index (AQI) and indicatory air pollutants of Anqing, Hefei, and Suzhou near central China from 2017 to 2019, and the impact of COVID-19 epidemic prevention and control actions on air quality were investigated. The combined data for the three cities from 2017 to 2019 indicated that the lowest AQI (averaged 78.1) occurred in the summer season, for which the AQI proportions for classes I, II, III, IV, V, and VI were 25.6%, 49.9%, 21.9%, 2.7%, 0%, and 0%, respectively. The highest (AQI average of 112.6) was in winter, for which the proportions were 7.4%, 39.5%, 33.3%, 12.5%, 7.2%, and 0.1%, respectively. PM2.5, PM10, and NO2 in order were the most important indicatory air pollutants for AQI classes IV, V, and VI, which all prevailed in winter and spring, while O3 was the indicatory air pollutant that occurred most in summer. The COVID-19 event, which triggered global attention, broke out at the end of 2019. This study also investigated and compared the air quality levels in the three cities from January to March 2017–2019 with those in 2020. The results showed that during February 2020, in the three cities, the average ambient air concentrations of PM2.5, PM10, SO2, CO, and NO2 were 41.9 µg m–3, 50.1 µg m–3, 2.18 ppb, 0.48 ppm, and 8.97 ppb, and were 46.5%, 48.9%, 52.5%, 36.2%, and 52.8%, respectively, lower than those in the same month in 2017–2019, respectively. However, the O3 average concentration (80.6 ppb) did not show significant fluctuations and even slightly increased by 3.6%. This is because a lower concentration of NO2 resulted in constraints on the reaction of NO + O3, so the O3 level could not be effectively further reduced. In addition, this study also analyzed and compared the five highest daily AQIs from February 2017–2019 with those of 2020 for the three cities. The mean AQI for the 5 days with the highest daily AQI (averaged 122.6) in February 2020 was 45.1% lower than that for February 2017–2019 (averaging 223.2), and the indicatory air pollutant was always PM2.5, which decreased by 46.7% (from 173.6 to 92.6 µg m–3). It is clear that during the COVID-19 epidemic prevention and control action periods, the air quality near central China improved significantly.
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- 2020
74. Covalent organic framework-supported platinum nanoparticles as efficient electrocatalysts for water reduction
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Wei Zhang, Yiming Hu, Joshua Jack, Shun Wan, Shaofeng Huang, Zhiyong Ren, Sadegh Yazdi, Pin Ching Maness, Yinghua Jin, and Eunsol Park
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Reaction rate ,Hydrogen ,chemistry ,Chemical engineering ,Hydride ,chemistry.chemical_element ,General Materials Science ,Platinum nanoparticles ,Redox ,Faraday efficiency ,Catalysis ,Covalent organic framework - Abstract
The hydrogen evolution reaction (HER) is one of the most effective and sustainable ways to produce hydrogen gas as an alternative clean fuel. The rate of this electrocatalytic reaction is highly dependent on the properties (dispersity and stability) of electrocatalysts. Herein, we developed well-dispersed and highly stable platinum nanoparticles (PtNPs) supported on a covalent organic framework (COF-bpyTPP), which exhibit excellent catalytic activities toward HER as well as the hydride reduction reaction. The nanoparticles have an average size of 2.95 nm and show superior catalytic performance compared to the commercially available Pt/C under the same alkaline conditions, producing 13 times more hydrogen with a far more positive onset potential (−0.13 V vs. −0.63 V) and ca. 100% faradaic efficiency. The reaction rate of the hydride reduction of 4-nitrophenol was also 10 times faster in the case of PtNPs@COF compared to the commercial Pt/C under the same loading and conditions. More importantly, the PtNPs@COF are highly stable under the aqueous reactions conditions and can be reused without showing noticeable aggregation and activity degradation.
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- 2020
75. Impact of the COVID-19 Event on Air Quality in Central China
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Kangping Cui, Li-Hao Young, Ya-Fen Wang, Shun Wan, Jiajia Zhang, Kaijie Xu, and Yen Kung Hsieh
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2019-20 coronavirus outbreak ,010504 meteorology & atmospheric sciences ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Air pollution ,Central china ,medicine.disease_cause ,01 natural sciences ,Pollution ,Toxicology ,Air pollutants ,Epidemic spread ,medicine ,Environmental Chemistry ,Environmental science ,Air quality index ,0105 earth and related environmental sciences - Abstract
In early 2020, the COVID-19 epidemic spread globally. This study investigated the air quality of three cities in Hubei Province, Wuhan, Jingmen, and Enshi, central China, from January to March 2017–2020 to analyze the impact of the epidemic prevention and control actions on air quality. The results indicated that in the three cities, during February 2020, when the epidemic prevention and control actions were taken, the average concentrations of atmospheric PM2.5, PM10, SO2, CO, and NO2 in the three cities were 46.1 µg m–3, 50.8 µg m–3, 2.56 ppb, 0.60 ppm, and 6.70 ppb, and were 30.1%, 40.5%, 33.4%, 27.9%, and 61.4% lower than the levels in February 2017–2019, respectively. However, the average O3 concentration (23.1, 32.4, and 40.2 ppb) in 2020 did not show a significant decrease, and even increased by 12.7%, 14.3%, and 11.6% in January, February, and March, respectively. This is because a lower concentration of NO2 resulted in constraints on the NO + O3 reaction, and the O3 could not be effectively further depleted. In addition, the average air quality index (AQI) for the three cities in January, February, and March 2020 were 32.2%, 27.7%, and 14.9% lower than the levels in 2017–2019, respectively. Based on the AQIs for the three cities, the combined proportions of Class I and Class Ⅱ in January, February, and March 2020 increased by 27.9%, 24.8%, and 4.3%, respectively, while the combined proportion of AQI Classes III, IV, V, and VI was reduced from 34.8% to 15.8%. In addition, in the first three months of 2020, the indicatory air pollutants in the three cities for the AQIs were predominant in the following order: PM2.5 (72.0%), O3 (16.4%), PM10 (8.3%), NO2 (2.9%), and CO (0.4%). This study provides useful information for establishing a scientific air pollution control strategy and is a valuable reference for future research on improving urban air quality.
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- 2020
76. Temporal Variations in the Air Quality Index and the Impact of the COVID-19 Event on Air Quality in Western China
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Jhong Lin Wu, Jiajia Zhang, Kangping Cui, Wei Syun Huang, Shun Wan, Ya-Fen Wang, and Kaijie Xu
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Pollutant ,2019-20 coronavirus outbreak ,010504 meteorology & atmospheric sciences ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,01 natural sciences ,Pollution ,Ambient air ,Animal science ,Atmospheric pollutants ,Environmental Chemistry ,Environmental science ,Air quality index ,0105 earth and related environmental sciences - Abstract
This study investigated the AQI (air quality index) and atmospheric pollutants including PM2.5, PM10, CO, SO2, NO2 and O3 in Chongqing, Luzhou and Chengdu from 2017 to 2019. In addition, the impacts of the COVID-19 event on the air quality in the three cities in 2020 were compared and discussed. For the combined AQIs for the three cities, in spring, the daily AQIs ranged between 25 and 182 and averaged 72.1. In summer, the daily AQIs ranged between 24 and 206 and averaged 77.5. In autumn, the daily AQIs ranged between 22 and 170 and averaged 61.1, and in winter, the daily AQIs ranged between 28 and 375 and averaged 99.6. The distributions of the six AQI classes in spring were 3%, 94%, 3%, 0%, 0%, and 0%; in summer, they were 11%, 74%, 15%, 0%, 0% and 0%; in autumn, they were 29%, 70%, 1%, 0%, 0%, and 0%, and in winter, they were 1%, 52%, 44%, 3%, 0%, and 0%, respectively. The average AQIs, in order, were Chengdu (85.4) > Chongqing (73.8) > Luzhou (73.2). Both the highest AQIs and PM2.5 (as the major indicatory air pollutant) occurred mainly in the low temperature season (January, December, and February), while O3 was the main air pollutant in June and August when the weather was hot. In February 2020, during the epidemic prevention and control actions taken in response to COVID-19 for the three cities, the combined AQIs for the top five days with the highest AQIs in February 2020 was 79.4, which was 23.6% lower than that from 2017–2019 (AQI = 100.7), and the average concentrations of PM2.5, PM10, SO2, CO, and NO2 were 89.4 µg m–3, 106 µg m–3, 2.31 ppb, 0.72 ppm, and 12.3 ppb, respectively, and were 17.9%, 30.8%, 83.8%, 19.8%, and 62.1%, lower than those in February 2017–2019. However, the average O3 concentration (31.8 ppb) in February 2020 rather than decreasing, increased by 6.2%. This is because a lower NO2 concentration hindered the NO + O3 reaction and led to increase O3 concentration in the ambient air.
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- 2020
77. Impact of the COVID-19 Event on Trip Intensity and Air Quality in Southern China
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Wei Syun Huang, Kaijie Xu, Jiajia Zhang, Shun Wan, Ya-Fen Wang, Kangping Cui, and Jhong Lin Wu
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Toxicology ,2019-20 coronavirus outbreak ,Air pollutants ,Southern china ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Environmental Chemistry ,Environmental science ,Pollution ,Air quality index ,Intensity (physics) - Abstract
The COVID-19 epidemic discovered and reported at the end of December 2019 and began spreading rapidly around the world. The impact of the COVID-19 event on the trip intensity, AQI (air quality index), and air pollutants, including PM2.5, PM10, SO2, CO, NO2, and O3 in Shenzhen, Guangzhou, and Foshan (the so-called ‘three cities’) from January 12 to March 27, in 2019 and 2020, are compared and discussed. In 2020, the combined trip intensity in the three cities ranged between 0.73 and 5.54 and averaged 2.57, which was 28.4% lower than that in 2019. In terms of the combined AQIs for the three cities, from January 12 to March 26, 2020, the daily AQIs ranged between 21.0 and 121.3 and averaged 56.4, which was 16.0% lower than that in 2019. The average AQIs in order were Guangzhou (57.5) > Foshan (54.1) > Shenzhen (44.1). In 2019, the distribution proportions of the six AQI classes were 45.2%, 50.4%, 4.40%, 0%, 0%, and 0%, respectively, while those in 2020 were 62.7%, 37.3%, 0%, 0%, 0% and 0%, respectively. For the combined data for the three cities, on the top five days with the highest AQIs during the epidemic period, the average concentrations of PM2.5, PM10, SO2, CO, NO2, and O3 were 76.4 μg m–3, 113.4 μg m–3, 5.14 ppb, 0.88 ppm, 36.5 ppb and 55.5 ppb, which were 55.2%, 49.4%, 55.1%, 30.0%, 45.1% and 15.5% lower than those during the non-epidemic period (from January 12 to March 27, 2017–2019). The above results revealed that the comprehensive strict epidemic prevention and control actions reduced trip intensity and improved the air quality significantly.
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- 2020
78. Microstructure and composition engineering Yb single-filled CoSb3 for high thermoelectric and mechanical performances
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Gerald Jeffrey Snyder, Shun Wan, Shijia Gu, Yuchi Fan, Xiaofang Lu, Matthias T. Agne, Wan Jiang, Qihao Zhang, Zhenxing Zhou, Qingfeng Song, Qing Xu, and Lianjun Wang
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Work (thermodynamics) ,Materials science ,Phonon scattering ,Scattering ,Metals and Alloys ,02 engineering and technology ,engineering.material ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Thermoelectric materials ,Cryogenic grinding ,Microstructure ,01 natural sciences ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Thermoelectric effect ,engineering ,lcsh:TA401-492 ,lcsh:Materials of engineering and construction. Mechanics of materials ,Skutterudite ,Composite material ,0210 nano-technology - Abstract
A broad tunability of the thermoelectric and mechanical properties of CoSb3 has been demonstrated by adjusting the composition with the addition of an increasing number of elements. However, such a strategy may negatively impact processing repeatability and composition control. In this work, single-element-filled skutterudite is engineered to have high thermoelectric and mechanical performances. Increased Yb filling fraction is found to increase phonon scattering, whereas cryogenic grinding contributes additional microstructural scattering. A peak zT of 1.55 and an average zT of about 1.09, which is comparable to the reported results of multiple-filled SKDs, are realized by the combination of simple composition and microstructure engineering. Furthermore, the mechanical properties of Yb single-filled CoSb3 skutterudite are improved by manipulation of the microstructure through cryogenic grinding. These findings highlight the realistic prospect of producing high-performance thermoelectric materials with reduced compositional complexity. Keywords: Skutterudites, Thermoelectric material, Compositional complexity, Microstructure engineering, Cryogenic grinding
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- 2019
79. Insulin-like growth factor 2 mRNA-binding protein 1 promotes cell proliferation via activation of AKT and is directly targeted by microRNA-494 in pancreatic cancer
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Ling Zhang, Bai-Shun Wan, and Ming Cheng
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Male ,Carcinogenesis ,medicine.medical_treatment ,Proliferation ,Datasets as Topic ,Down-Regulation ,Kaplan-Meier Estimate ,Biology ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Downregulation and upregulation ,Pancreatic cancer ,Cell Line, Tumor ,microRNA ,medicine ,Gene silencing ,Animals ,Humans ,Insulin-like growth factor 2 mRNA-binding protein 1 ,Protein kinase B ,Pancreas ,Cell Proliferation ,Cell growth ,Akt/PKB signaling pathway ,Growth factor ,Gastroenterology ,RNA-Binding Proteins ,General Medicine ,Basic Study ,Middle Aged ,medicine.disease ,Prognosis ,Xenograft Model Antitumor Assays ,Up-Regulation ,Gene Expression Regulation, Neoplastic ,Pancreatic Neoplasms ,MicroRNAs ,030220 oncology & carcinogenesis ,Cancer research ,030211 gastroenterology & hepatology ,Female ,Proto-Oncogene Proteins c-akt ,MicroRNA-494 ,Signal Transduction - Abstract
Background Studies have shown that insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) plays critical roles in the genesis and development of human cancers. Aim To investigate the clinical significance and role of IGF2BP1 in pancreatic cancer. Methods Expression levels of IGF2BP1 and microRNA-494 (miR-494) were mined based on Gene Expression Omnibus datasets and validated in both clinical samples and cell lines by quantitative real-time polymerase chain reaction and Western blot. The relationship between IGF2BP1 expression and clinicopathological factors of pancreatic cancer patients was analyzed. The effect and mechanism of IGF2BP1 on pancreatic cancer cell proliferation were investigated in vitro and in vivo. Analyses were performed to explore underlying mechanisms of IGF2BP1 upregulation in pancreatic cancer and assays were carried out to verify the post-transcriptional regulation of IGF2BP1 by miR-494. Results We found that IGF2BP1 was upregulated and associated with a poor prognosis in pancreatic cancer patients. We showed that downregulation of IGF2BP1 inhibited pancreatic cancer cell growth in vitro and in vivo via the AKT signaling pathway. Mechanistically, we showed that the frequent upregulation of IGF2BP1 was attributed to the downregulation of miR-494 expression in pancreatic cancer. Furthermore, we discovered that reexpression of miR-494 could partially abrogate the oncogenic role of IGF2BP1. Conclusion Our results revealed that upregulated IGF2BP1 promotes the proliferation of pancreatic cancer cells via the AKT signaling pathway and confirmed that the activation of IGF2BP1 is partly due to the silencing of miR-494.
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- 2019
80. [The Current Status and Research Progress of Antiviral Therapy in HCV-Associated Lymphoma --Review]
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Xiao-Hong, Sun, Shun, Wan, and Zi-Jian, Li
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Humans ,Hepacivirus ,Lymphoma, B-Cell, Marginal Zone ,Lymphoma, Large B-Cell, Diffuse ,Hepatitis C, Chronic ,Antiviral Agents ,Hepatitis C - Abstract
Hepatitis C virus (HCV) is one of the leading causes of chronic liver disease. HCV is not only related to hepatic malignancies but may also promote lymphoid neoplasms. Currently, research has confirmed HCV-related lymphoma, including marginal zone lymphoma (MZL), lymphoplasmacytic lymphoma (LPL), follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL), and Burkitt lymphoma (BL). Many types of research have shown that antiviral therapy can improve or even remission several HCV-related lymphomas. The direct-acting antiviral agents (DAAs) (such as NS5A protease inhibitors, NS4/4A protease inhibitors and viral polymerase inhibitors) have shown clinical advantages of high efficacy and low side effects for both virus elimination and tumor regression in several HCV-related lymphomas, which may make the selected HCV-related lymphoma patients treated without chemotherapy. In this review the research progress and development direction of antiviral therapy in treating HCV-related lymphoma has summarized briefly.抗病毒治疗在HCV相关淋巴瘤中的治疗现状及研究进展.丙型肝炎病毒(hepatitis C virus,HCV)是全球慢性肝病的主要病因之一,它不仅与肝脏恶性肿瘤相关,而且可能促进淋巴增殖性疾病的发生和发展。目前已证实与HCV有关的淋巴系统增殖性疾病包括边缘区淋巴瘤、淋巴浆细胞性淋巴瘤、滤泡淋巴瘤、弥漫性大B细胞淋巴瘤和Burkits淋巴瘤。许多研究表明,抗病毒治疗后,这些HCV相关的淋巴瘤会随着HCV的消除而减轻甚至缓解。随着NS5A蛋白酶抑制剂、NS4/4A蛋白酶抑制剂和病毒聚合酶抑制剂的出现,它们在HCV相关淋巴瘤中表现出高疗效、低副作用的临床优势,可能使特定的丙肝相关淋巴瘤患者免于免疫化疗。本文对抗病毒治疗在HCV相关淋巴瘤治疗中的研究进展和发展方向作一综述.
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- 2021
81. A Fully Integrated High-Efficiency Three-stage Doherty Power Amplifier for Small-cell application
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Shun Wan, WenHua Chen, Guansheng Lv, Long Chen, and Zhenghe Feng
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- 2021
82. In vitro Tracheobronchial Relaxation of Fritillaria Alkaloids
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CHAN, Shun-Wan, LI, Ping, KWAN, Yiu-Wa, and LIN, Ge
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- 2011
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83. Peripheral Lymphocyte Count, Free/Total PSA Ratio, LUTS Predict The Severity of Prostatic Inflammation in BPH Patients
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Gong-Jun Guo, Jun Mi, Zhi Yang, Xiaohong Sun, Fang-Ming Du, Yong-Shuai Lin, Shun Wan, and Yu-Qiang Fu
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medicine.medical_specialty ,medicine.anatomical_structure ,business.industry ,Lymphocyte ,medicine ,Urology ,Inflammation ,medicine.symptom ,urologic and male genital diseases ,business ,Peripheral ,Total psa - Abstract
Objective To study the correlation between peripheral blood lymphocytes, f/t PSA and LUTS symptoms, and prostatic inflammation in BPH patients.Materials and Methods From May 2020 to October 2020, 120 patients (aged 56-85 years) with BPH undergoing elective transurethral resection of the prostate (TURP) were selected. Peripheral blood lymphocyte counts and f/t PSA values were measured preoperatively, and IPSS scores were assessed. Postoperative prostate tissues were sent for pathological examination, and the relationship between peripheral blood lymphocyte count, TPSA, f/t PSA values, relevant clinical laboratory parameters, and relevant LUTS symptoms and the distribution of prostate tissue inflammation was analyzed.Results with the aggravation of prostatic inflammation, IPSS score and TPSA value were lower, while f/t PSA value and lymphocyte count were lower. Multivariate logistic regression analysis of 120 BPH patients showed that age (> = 60) [odds ratio (OR) = 0.29, 95% CI = 0.31-2.10; P = 0.02], IPSS score [OR = 1.24, 95% CI = 1.13-1.37; P < 0.01], TPSA [OR = 1.10, 95% CI = 1.02-1.19; P = 0.02], f/t PSA [OR = 1.03, 95% CI = 0.01-0.15; P = 0.02], and lymphocytes [OR = 1.70, 95% CI = 0.78-3.77; P = 0.04] were related to the formation of prostatic inflammation in BPH patients. Conclusion Peripheral blood lymphocyte count, TPSA, LUTS severity, and f/t PSA ratio can predict the severity of prostatic inflammation, which may be used as diagnostic markers for BPH patients with LUTS symptoms who have prostatitis and promote the development of drug treatment for LUTS symptoms in BPH patients with prostatitis.
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- 2021
84. Emodin elicits cytotoxicity in human lung adenocarcinoma A549 cells through inducing apoptosis
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Li, Wing-Yan, Ng, Yam-Fung, Zhang, Huan, Guo, Zi-Dong, Guo, De-Jian, Kwan, Yiu-Wa, Leung, George Pak-Heng, Lee, Simon Ming-Yuen, Yu, Peter Hoi-Fu, and Chan, Shun-Wan
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- 2014
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85. A restricted dynamic surface self-reconstruction toward high-performance of direct seawater oxidation
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Ling Zhou, Daying Guo, Lianhui Wu, Zhixi Guan, Chao Zou, Huile Jin, Guoyong Fang, Xi’an Chen, and Shun Wang
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Science - Abstract
Abstract The development of highly efficient electrocatalysts for direct seawater splitting with bifunctionality for inhibiting anodic oxidation reconstruction and selective oxygen evolution reactions is a major challenge. Herein, we report a direct seawater oxidation electrocatalyst that achieves long-term stability for more than 1000 h at 600 mA/cm2@η600 and high selectivity (Faraday efficiency of 100%). This catalyst revolves an amorphous molybdenum oxide layer constructed on the beaded-like cobalt oxide interface by atomic layer deposition technology. As demonstrated, a new restricted dynamic surface self-reconstruction mechanism is induced by the formation a stable reconstructed Co-Mo double hydroxide phase interface layer. The device assembled into a two-electrode flow cell for direct overall seawater electrolysis maintained at 1 A/cm2@1.93 V for 500 h with Faraday efficiency higher than 95%. Hydrogen generation rate reaches 419.4 mL/cm2/h, and the power consumption (4.62 KWh/m3 H2) is lower than that of pure water (5.0 KWh/m3 H2) at industrial current density.
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- 2024
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86. Alpha5 nicotine acetylcholine receptor subunit promotes intrahepatic cholangiocarcinoma metastasis
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Yan Fu, Keyu Shen, Hao Wang, Shun Wang, Xufeng Wang, Le Zhu, Yan Zheng, Tiantian Zou, Hongfei Ci, Qiongzhu Dong, and Lun-Xiu Qin
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Medicine ,Biology (General) ,QH301-705.5 - Abstract
Abstract Neurotransmitter-initiated signaling pathway were reported to play an important role in regulating the malignant phenotype of tumor cells. Cancer cells could exhibit a “neural addiction” property and build up local nerve networks to achieve an enhanced neurotransmitter-initiated signaling through nerve growth factor-mediated axonogenesis. Targeting the dysregulated nervous systems might represent a novel strategy for cancer treatment. However, whether intrahepatic cholangiocarcinoma (ICC) could build its own nerve networks and the role of neurotransmitters in the progression ICC remains largely unknown. Immunofluorescence staining and Enzyme-linked immunosorbent assay suggested that ICC cells and the infiltrated nerves could generate a tumor microenvironment rich in acetylcholine that promotes ICC metastasis by inducing epithelial-mesenchymal transition (EMT). Acetylcholine promoted ICC metastasis through interacting with its receptor, alpha 5 nicotine acetylcholine receptor subunits (CHRNA5). Furthermore, acetylcholine/CHRNA5 axis activated GSK3β/β-catenin signaling pathway partially through the influx of Ca2+-mediated activation of Ca/calmodulin-dependent protein kinases (CAMKII). In addition, acetylcholine signaling activation also expanded nerve infiltration through increasing the expression of Brain-Derived Neurotrophic Factor (BDNF), which formed a feedforward acetylcholine-BDNF axis to promote ICC progression. KN93, a small-molecule inhibitor of CAMKII, significantly inhibited the migration and enhanced the sensitivity to gemcitabine of ICC cells. Above all, Acetylcholine/CHRNA5 axis increased the expression of β-catenin to promote the metastasis and resistance to gemcitabine of ICC via CAMKII/GSK3β signaling, and the CAMKII inhibitor KN93 may be an effective therapeutic strategy for combating ICC metastasis.
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- 2024
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87. Machine learning reveals diverse cell death patterns in lung adenocarcinoma prognosis and therapy
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Shun Wang, Ruohuang Wang, Dingtao Hu, Caoxu Zhang, Peng Cao, and Jie Huang
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Cancer cell growth, metastasis, and drug resistance pose significant challenges in the management of lung adenocarcinoma (LUAD). However, there is a deficiency in optimal predictive models capable of accurately forecasting patient prognoses and guiding the selection of targeted treatments. Programmed cell death (PCD) pathways play a pivotal role in the development and progression of various cancers, offering potential as prognostic indicators and drug sensitivity markers for LUAD patients. The development and validation of predictive models were conducted by integrating 13 PCD patterns with comprehensive analysis of bulk RNA, single-cell RNA transcriptomics, and pertinent clinicopathological details derived from TCGA-LUAD and six GEO datasets. Utilizing the machine learning algorithms, we identified ten critical differentially expressed genes associated with PCD in LUAD, namely CHEK2, KRT18, RRM2, GAPDH, MMP1, CHRNA5, TMPRSS4, ITGB4, CD79A, and CTLA4. Subsequently, we conducted a programmed cell death index (PCDI) based on these genes across the aforementioned cohorts and integrated this index with relevant clinical features to develop several prognostic nomograms. Furthermore, we observed a significant correlation between the PCDI and immune features in LUAD, including immune cell infiltration and the expression of immune checkpoint molecules. Additionally, we found that patients with a high PCDI score may exhibit resistance to immunotherapy and standard adjuvant chemotherapy regimens; however, they may benefit from other FDA-supported drugs such as docetaxel and dasatinib. In conclusion, the PCDI holds potential as a prognostic signature and can facilitate personalized treatment for LUAD patients.
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- 2024
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88. Cirrhotic-extracellular matrix attenuates aPD-1 treatment response by initiating immunosuppressive neutrophil extracellular traps formation in hepatocellular carcinoma
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Xiao-Tian Shen, Sun-Zhe Xie, Xin Zheng, Tian-Tian Zou, Bei-Yuan Hu, Jing Xu, Lu Liu, Yun-Feng Xu, Xu-Feng Wang, Hao Wang, Shun Wang, Le Zhu, Kang-Kang Yu, Wen-Wei Zhu, Lu Lu, Ju-Bo Zhang, Jin-Hong Chen, Qiong-Zhu Dong, Lu-Yu Yang, and Lun-Xiu Qin
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Hepatocellular carcinoma (HCC) ,Immune checkpoint inhibitor (ICI) ,Neutrophil extracellular traps (NETs) ,Extracellular matrix (ECM) ,Collagen type I (Col1) ,Diseases of the blood and blood-forming organs ,RC633-647.5 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Hepatocellular carcinoma (HCC) is closely associatedwith chronic liver diseases, particularly liver cirrhosis, which has an altered extracellular matrix (ECM) composition. The influence and its mechanism of the cirrhotic-ECM on the response of HCC to immune checkpoint inhibitor (ICI) remains less clarified. Methods In silico, proteomic and pathological assessment of alteration of cirrhotic-ECM were applied in clinical cohort. Multiple pre-clinical models with ECM manipulation were used to evaluate cirrhotic-ECM’s effect on ICI treatment. In silico, flow cytometry and IHC were applied to explore how cirrhotic-ECM affect HCC microenvironment. In vitro and in vivo experiments were carried out to identify the mechanism of how cirrhotic-ECM undermined ICI treatment. Results We defined “a pro-tumor cirrhotic-ECM” which was featured as the up-regulation of collagen type 1 (Col1). Cirrhotic-ECM/Col1 was closely related to impaired T cell function and limited anti PD-1 (aPD-1) response of HCC patients from the TCGA pan cancer cohort and the authors’ institution, as well as in multiple pre-clinical models. Mechanically, cirrhotic-ECM/Col1 orchestrated an immunosuppressive microenvironment (TME) by triggering Col1-DDR1-NFκB-CXCL8 axis, which initiated neutrophil extracellular traps (NETs) formation to shield HCC cells from attacking T cells and impede approaching T cells. Nilotinib, an inhibitor of DDR1, reversed the neutrophils/NETs dominant TME and efficiently enhanced the response of HCC to aPD-1. Conclusions Cirrhotic-ECM modulated a NETs enriched TME in HCC, produced an immune suppressive TME and weakened ICI efficiency. Col1 receptor DDR1 could be a potential target synergically used with ICI to overcome ECM mediated ICI resistance. These provide a mechanical insight and novel strategy to overcome the ICI resistance of HCC.
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- 2024
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89. Effects of miR-214 on adenosine A2A receptor and carboxymethyl chitosan nanoparticles on the function of keloid fibroblasts and their mechanisms
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Yong Du, Jing Liu, Qing Hao, Shun Wang, Aijun Zhang, Yongzhong Li, and Ninghan Feng
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miR-214 ,Keloid fibroblasts ,Adenosine A2AR ,Cell apoptosis ,Cell proliferation ,Carboxymethyl chitosan nanoparticles ,Medicine ,Science - Abstract
Abstract This work prepared and investigated the impact of carboxymethyl chitosan nanoparticles (MC-NPs) on the proliferative capability of keloid fibroblasts (KFBs) while analyzing the mechanistic roles of miR-214 and adenosine A2A receptor (A2AR) in fibroblasts within hypertrophic scars. MC-NPs were synthesized through ion cross-linking, were characterized using transmission electron microscopy (TEM) and laser particle size scattering. The influence of MC-NPs on the proliferation capacity of KFBs was assessed using the MTT method. Changes in the expression levels of miR-214 and A2AR in KFBs, normal skin fibroblasts (NFBs), hypertrophic scar tissue, and normal skin tissue were analyzed. KFBs were categorized into anti-miR-214, anti-miR-NC, miR-214 mimics, miR-NC, si-A2AR, si-con, anti-miR-214+ si-con, and anti-miR-214+ si-A2AR groups. Bioinformatics target prediction was conducted to explore the interaction between miR-214 and A2AR. Real-time quantitative PCR and immunoblotting (WB) were employed to detect the expression levels of miR-214, A2AR, apoptotic protein Bax, and TGF-β in different cells. Cell counting kit-8 (CCK8) and flow cytometry were employed to assess cell proliferation activity and apoptosis. The results indicated that MC-NPs exhibited spherical particles with an average diameter of 236.47 ± 4.98 nm. The cell OD value in the MC-NPs group was lower than that in KFBs (P
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- 2024
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90. In vitro vitamin K2 and 1α,25-dihydroxyvitamin D3 combination enhances osteoblasts anabolism of diabetic mice
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Poon, Christina C.W., Li, Rachel W.S., Seto, Sai Wang, Kong, Siu Kai, Ho, Ho Pui, Hoi, Maggie P.M., Lee, Simon M.Y., Ngai, Sai Ming, Chan, Shun Wan, Leung, George P.H., and Kwan, Yiu Wa
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- 2015
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91. Consumption of dried fruit of Crataegus pinnatifida (hawthorn) suppresses high-cholesterol diet-induced hypercholesterolemia in rats
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Kwok, Ching-Yee, Wong, Candy Ngai-Yan, Yau, Mabel Yin-Chun, Yu, Peter Hoi-Fu, Au, Alice Lai Shan, Poon, Christina Chui-Wa, Seto, Sai-Wang, Lam, Tsz-Yan, Kwan, Yiu-Wa, and Chan, Shun-Wan
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- 2010
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92. Folic acid consumption reduces resistin level and restores blunted acetylcholine-induced aortic relaxation in obese/diabetic mice
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Seto, Sai Wang, Lam, Tsz Yan, Or, Penelope Mei Yu, Lee, Wayne Yuk Wai, Au, Alice Lai Shan, Poon, Christina Chui Wa, Li, Rachel Wai Sum, Chan, Shun Wan, Yeung, John Hok Keung, Leung, George Pak Heng, Lee, Simon Ming Yuen, Ngai, Sai Ming, and Kwan, Yiu Wa
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- 2010
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93. Formononetin, an isoflavone, relaxes rat isolated aorta through endothelium-dependent and endothelium-independent pathways
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Wu, Jian-Hong, Li, Qing, Wu, Min-Yi, Guo, De-Jian, Chen, Huan-Le, Chen, Shi-Lin, Seto, Sai-Wang, Au, Alice L.S., Poon, Christina C.W., Leung, George P.H., Lee, Simon M.Y., Kwan, Yiu-Wa, and Chan, Shun-Wan
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- 2010
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94. A High-Efficiency Two-Stage GaAs HBT Doherty Power Amplifier With Thermal Compensation for WLAN Application
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DongHao Li, Shun Wan, Zhenghe Feng, Bowen Xia, Long Chen, Wenhua Chen, and Guansheng Lv
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Power-added efficiency ,Materials science ,business.industry ,Amplifier ,Heterojunction bipolar transistor ,dBc ,law.invention ,QAM ,law ,Adjacent channel ,Optoelectronics ,Wi-Fi ,business ,Leakage (electronics) - Abstract
In this paper, a high-efficiency Doherty power amplifier (DPA) using an InGaP/GaAs heterojunction bipolar transistor (HBT) process is presented. The DPA aims for the application of 2.4 GHz wireless local area network (WLAN) systems with a high peak-to-average power ratio (PAPR). The traditional bulky quarter-wavelength line is realized using a low-pass n-type network for miniaturization and low loss. A thermally compensated dynamic bias circuit is applied to increase thermal stability. Under the excitation of a 40-MHz 64-quadratic-amplitude modu-lation(QAM) signal, the proposed DPA achieves a gain of 29 dB gain, an average power of 26 dBm, and an average power added efficiency (PAE) up to 21%. Good error vector magnitude (EVM) and adjacent channel leakage ratio (ACLR) performance are also measured, which demonstrates EVM and ACLR after digital pre-distortion (DPD) are −42 dB and −50.7 dBc. respectively.
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- 2021
95. Evolution of Structural and Electronic Properties in NbTe
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Shujia, Li, Qing, Dong, Jiajia, Feng, Yanju, Wang, Mingqiang, Hou, Wen, Deng, Resta A, Susilo, Nana, Li, Hongliang, Dong, Shun, Wan, Chunxiao, Gao, and Bin, Chen
- Abstract
Transition metal dichalcogenides (TMDs) have attracted wide attention due to their quasi-two-dimensional layered structure and exotic properties. Plenty of efforts have been done to modulate the interlayer stacking manner for novel states. However, as an equally important element in shaping the unique properties of TMDs, the effect of intralayer interaction is rarely revealed. Here, we report a particular case of pressure-tuned re-arrangement of intralayer atoms in distorted 1T-NbTe
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- 2021
96. Revealing the mechanism: the influence of Baicalin on M1/M2 and Th1/Th2 imbalances in mycoplasma gallisepticum infection
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Yuquan Guo, Yusong Miao, Hao Chen, Kexin Wang, Shun Wang, Rui Wang, Zhiyong Wu, and Jichang Li
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Mycoplasma gallisepticum (MG) ,baicalin ,M1/M2 ,Th1/Th2 ,inflammatory impairment ,Animal culture ,SF1-1100 - Abstract
Mycoplasma gallisepticum (MG) is a pathogen that induces chronic respiratory illnesses in chickens, leading to tracheal and lung injury, and eliciting immune reactions that support sustained colonization. Baicalin, a compound found in scutellaria baicalensis, exhibits anti-inflammatory, antioxidant, and antibacterial properties. This study aimed to investigate the potential of baicalin in alleviating lung and cell damage caused by MG by restoring imbalances in M1/M2 and Th1/Th2 differentiation and to explore its underlying mechanism. In this research, a model for M1/M2 polarization induced by MG was initially developed. Specifically, infection with MG at a multiplicity of infection (MOI) of 400 for 6 h represented the M1 model, while infection for 10 h represented the M2 model. The polarization markers were subsequently validated using qRT-PCR, ELISA, and Western blot analysis. Baicalin disrupts the activation of M1 cells induced by MG and has the potential to restore the balance between M1 and M2 cells, thereby mitigating the inflammatory damage resulting from MG. Subsequent studies on MG-infected chickens detected imbalances in M1/M2 and Th1/Th2 differentiation in alveolar lavage fluid, as well as imbalances in macrophages and Th cells in the lung. The M1/Th1 model was exposed to MG for 5 d, while the M2/Th2 model was infected with MG for 7 d. The utilization of both light and electron transmission microscopes revealed that the administration of baicalin resulted in a reduction in the number of M1 cells, a decrease in cytoplasmic vacuoles, restoration of mitochondrial swelling and chromatin agglutination, as well as alleviation of alveolar rupture and inflammatory cell infiltration. Furthermore, baicalin restored MG-induced M1/M2 and Th1/Th2 imbalances and inhibited the phosphorylation of p38 and p65 proteins, thereby hindering the activation of the TLR4-p38 MAPK/NF-κB pathway. This study provides insights into the potential long-term effects of baicalin in MG infection and offers a theoretical basis for practical applications.
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- 2024
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97. Crystalline Lithium Imidazolate Covalent Organic Frameworks with High Li-Ion Conductivity
- Author
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Nathan Dunlap, Se-Hee Lee, Shuanglong Lu, Yiming Hu, Isaac Sellinger, Yinghua Jin, Wei Zhang, Shun Wan, Michael Ortiz, and Shaofeng Huang
- Subjects
Chemistry ,Ionic bonding ,chemistry.chemical_element ,General Chemistry ,Electrolyte ,Activation energy ,Conductivity ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Catalysis ,0104 chemical sciences ,Ion ,Crystallography ,chemistry.chemical_compound ,Colloid and Surface Chemistry ,Covalent bond ,Imidazolate ,Lithium - Abstract
Ionic covalent organic frameworks (ICOFs) have recently emerged as promising candidates for solid-state electrolytes. Herein, we report the first example of a series of crystalline imidazolate-containing ICOFs as single-ion conducting COF solid electrolyte materials, where lithium cations freely travel through the intrinsic channels with outstanding ion conductivity (up to 7.2 × 10-3 S cm-1) and impressively low activation energy (as low as 0.10 eV). These properties are attributed to the weak Li ion-imidazolate binding interactions and well-defined porous 2D framework structures of such ICOFs. We also investigated the structure-property relationship by varying the electronic properties of substituents (electron donating/withdrawing) that covalently attached to the imidazolate groups. We found electron-withdrawing substituents significantly improve the ion-conducting ability of imidazolate-ICOF by weakening ion-pair interactions. Our study provides a convenient bottom-up approach toward a novel class of highly efficient single-ion conducting ICOFs which could be used in all solid-state electrolytic devices.
- Published
- 2019
98. Ultra-high quality perfect absorber based on quasi bound states in the continuum
- Author
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Shun Wan, Chunhua Qin, Keda Wang, Yicheng Li, Chunying Guan, Bo Lv, Wenjia Li, and Jinhui Shi
- Subjects
General Physics and Astronomy - Abstract
Ultra-high-quality perfect optical absorption structures based on quasi-bound states in the continuum (quasi-BICs) are investigated and numerically demonstrated. When the radiation rate of the magnetic dipole quasi-BICs resonance is equal to the dissipate loss rate of the system, the critical coupling condition is satisfied and the perfect absorption (nearly 100%) is obtained. The ultra-high-quality factor (1.7 × 105) perfect absorption in the proposed design is mainly attributed to the extremely low external leakage loss rate of quasi-BIC and relatively small intrinsic absorption loss rate in the constituent materials. The structure exhibits excellent sensing properties with a sensitivity of 108 nm/RIU and ultra-high FOM of ∼12013. The proposed scheme is of importance in potential biosensing applications.
- Published
- 2022
99. Highly Fluoro-Substituted Covalent Organic Framework and Its Application in Lithium–Sulfur Batteries
- Author
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Guipeng Yu, Wei Zhang, Kai Han, De-Gao Wang, Yiming Hu, Min Song, Shun Wan, Weifeng Wei, Yinghua Jin, Nuo Li, and Gui-Chao Kuang
- Subjects
inorganic chemicals ,Materials science ,chemistry.chemical_element ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Electrochemistry ,01 natural sciences ,Sulfur ,Cathode ,0104 chemical sciences ,Amorphous solid ,law.invention ,Chemical kinetics ,chemistry ,Chemical engineering ,Physisorption ,law ,Nucleophilic aromatic substitution ,General Materials Science ,0210 nano-technology ,Covalent organic framework - Abstract
We report the preparation of a highly fluoro-substituted crystalline covalent organic framework (COF) and its application as a cathode material in lithium-sulfur batteries (LSBs) upon sulfur confinement. A sulfur-functionalized COF with high sulfur content (60 wt %) was obtained through physisorption of elemental sulfur and subsequent SNAr reaction of sulfur with aromatic fluorides on the COF backbone. After such physical and chemical confinement of sulfur through a postfunctionalization approach, the COF material still shows some structural order, allowing us to investigate the structure-property relationship of such COF materials in LSB application. We compared the electrochemical performances of the two cathode materials prepared from a crystalline COF and its amorphous counterpart and studied the important factors that affect battery capacity, reaction kinetics, and cycling stability.
- Published
- 2018
100. Water extract of Rheum officinale Baill. induces apoptosis in human lung adenocarcinoma A549 and human breast cancer MCF-7 cell lines
- Author
-
Li, Wing-Yan, Chan, Shun-Wan, Guo, De-Jian, Chung, Mei-Kuen, Leung, Tin-Yan, and Yu, Peter Hoi-Fu
- Published
- 2009
- Full Text
- View/download PDF
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