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5,260 results on '"Singh, Mandeep"'

52. Effect of prophylactic corticosteroids on postoperative neurocognitive dysfunction in the adult population: An updated systematic review, meta-analysis, and trial sequential analysis of randomised controlled trials

Author

Singh, Narinder P., Makkar, Jeetinder K., Goel, Nitika, Karamchandani, Kunal, Singh, Mandeep, and Singh, Preet M.

Subjects
Prevention, Risk factors, Patient outcomes, Dosage and administration, Methods, Cognitive disorders -- Risk factors -- Prevention, Prophylaxis -- Methods -- Patient outcomes, Postoperative complications -- Risk factors -- Prevention, Corticosteroid drugs -- Dosage and administration -- Patient outcomes, Corticosteroids -- Dosage and administration -- Patient outcomes, Cognition disorders -- Risk factors -- Prevention, Surgery -- Complications
Abstract

Author(s): Narinder P. Singh [1]; Jeetinder K. Makkar (corresponding author) [2]; Nitika Goel [2]; Kunal Karamchandani [3]; Mandeep Singh [4]; Preet M. Singh [5] INTRODUCTION Postoperative neurocognitive dysfunction (PNCD) is [...], Background and Aims: Postoperative neurocognitive dysfunction (PNCD) commonly occurs after surgery and prolongs hospital stays. Both direct noxious stimuli to the central nervous system and systemic inflammation have been implicated. Due to their potent anti-inflammatory effects, corticosteroids have been utilised to attenuate the incidence and severity of PNCD. This systematic review and meta-analysis strived to evaluate the prophylactic role of perioperative corticosteroids for PNCD. Methods: A search was run in pre-defined databases for randomised controlled trials (RCTs) assessing the role of corticosteroids in preventing PNCD. The incidence of PNCD within 1 month was the primary outcome. Secondary outcomes included the use of antipsychotic medications for the treatment, postoperative infection, and hospital length of stay. The results are exhibited as odds ratio (OR) and the mean difference (MD) with 95% confidence interval (CI). Results: Fifteen RCTs comprising 15,398 patients were included. The incidence of PNCD was significantly lower in the corticosteroid group than in the control group, with a pooled OR of 0.75 (95% CI 0.58, 0.96; P = 0.02; I[sup.2] = 66%). Trial sequential analysis showed the clinical benefit of corticosteroids in preventing PNCD; however, the requisite information size is still inadequate. The sub-group analysis supported the prophylactic effect of corticosteroids on delirium prevention but not on delayed neurocognitive recovery. Conclusions: Our meta-analysis revealed statistically significant protective effects of corticosteroids on the incidence of PNCD. However, further studies are still needed to confirm the protective role of this commonly used and relatively safe strategy for preventing PNCD. Keywords: Corticosteroids, delayed neurocognitive recovery, delirium, dexamethasone, meta-analysis, postoperative cognitive dysfunction, post-operative neurocognitive dysfunction, systematic review, trial sequential analysis

Published
2024
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96. Deep Learning Approaches for Real-Time Data Analytics in IoT Sensor Networks

Author

Mary, P. Arockia, Sharma, Avinash, Dekka, Satish, Gowda, V. Dankan, Singh, Mandeep, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Rathore, Vijay Singh, editor, Piuri, Vincenzo, editor, Babo, Rosalina, editor, and S, Karthik, editor

Published
2024
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98. Unveiling Deepfakes: Convolutional Neural Networks for Detection

Author

Kaushik, Bhavana, Vinay, K., Singh, Mandeep, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Abraham, Ajith, editor, Bajaj, Anu, editor, Hanne, Thomas, editor, and Hong, Tzung-Pei, editor

Published
2024
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99. Securing Lives and Assets: IoT-Based Earthquake and Fire Detection for Real-Time Monitoring and Safety

Author

Singh, Ramveer, Sharma, Rahul, Kumar, Kaushal, Singh, Mandeep, Vajpayee, Pooja, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Garg, Deepak, editor, Rodrigues, Joel J. P. C., editor, Gupta, Suneet Kumar, editor, Cheng, Xiaochun, editor, Sarao, Pushpender, editor, and Patel, Govind Singh, editor

Published
2024
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100. Drain Current and Transconductance Analysis of Double-Gate Vertical Doped Layer TFET

Author

Singh, Mandeep, Teja, Nakkina Sai, Chaudhary, Tarun, Raj, Balwinder, Kakkar, Deepti, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Sharma, Devendra Kumar, editor, Peng, Sheng-Lung, editor, Sharma, Rohit, editor, and Jeon, Gwanggil, editor

Published
2024
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