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516 results on '"Singh, Shiv P."'

52. TNF-α-producing macrophages determine subtype identity and prognosis via AP1 enhancer reprogramming in pancreatic cancer

Author

Tu, Mengyu, Klein, Lukas, Espinet, Elisa, Georgomanolis, Theodoros, Wegwitz, Florian, Li, Xiaojuan, Urbach, Laura, Danieli-Mackay, Adi, Küffer, Stefan, Bojarczuk, Kamil, Mizi, Athanasia, Günesdogan, Ufuk, Chapuy, Björn, Gu, Zuguang, Neesse, Albrecht, Kishore, Uday, Ströbel, Philipp, Hessmann, Elisabeth, Hahn, Stephan A., Trumpp, Andreas, Papantonis, Argyris, Ellenrieder, Volker, and Singh, Shiv K.

Published
2021
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65. Fungal diversity notes 1151–1276: taxonomic and phylogenetic contributions on genera and species of fungal taxa

Author

Hyde, Kevin D., Dong, Yang, Phookamsak, Rungtiwa, Jeewon, Rajesh, Bhat, D. Jayarama, Jones, E. B. Gareth, Liu, Ning-Guo, Abeywickrama, Pranami D., Mapook, Ausana, Wei, Deping, Perera, Rekhani H., Manawasinghe, Ishara S., Pem, Dhandevi, Bundhun, Digvijayini, Karunarathna, Anuruddha, Ekanayaka, Anusha H., Bao, Dan-Feng, Li, Junfu, Samarakoon, Milan C., Chaiwan, Napalai, Lin, Chuan-Gen, Phutthacharoen, Kunthida, Zhang, Sheng-Nan, Senanayake, Indunil C., Goonasekara, Ishani D., Thambugala, Kasun M., Phukhamsakda, Chayanard, Tennakoon, Danushka S., Jiang, Hong-Bo, Yang, Jing, Zeng, Ming, Huanraluek, Naruemon, Liu, Jian-Kui (Jack), Wijesinghe, Subodini N., Tian, Qing, Tibpromma, Saowaluck, Brahmanage, Rashika S., Boonmee, Saranyaphat, Huang, Shi-Ke, Thiyagaraja, Vinodhini, Lu, Yong-Zhong, Jayawardena, Ruvishika S., Dong, Wei, Yang, Er-Fu, Singh, Sanjay K., Singh, Shiv Mohan, Rana, Shiwali, Lad, Sneha S., Anand, Garima, Devadatha, Bandarupalli, Niranjan, M., Sarma, V. Venkateswara, Liimatainen, Kare, Aguirre-Hudson, Begoña, Niskanen, Tuula, Overall, Andy, Alvarenga, Renato Lúcio Mendes, Gibertoni, Tatiana Baptista, Pfliegler, Walter P., Horváth, Enikő, Imre, Alexandra, Alves, Amanda Lucia, da Silva Santos, Ana Carla, Tiago, Patricia Vieira, Bulgakov, Timur S., Wanasinghe, Dhanushaka N., Bahkali, Ali H., Doilom, Mingkwan, Elgorban, Abdallah M., Maharachchikumbura, Sajeewa S. N., Rajeshkumar, Kunhiraman C., Haelewaters, Danny, Mortimer, Peter E., Zhao, Qi, Lumyong, Saisamorn, Xu, Jianchu, and Sheng, Jun

Published
2020
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66. Antithetical NFATc1–Sox2 and p53–miR200 signaling networks govern pancreatic cancer cell plasticity

Author

Singh, Shiv K, Chen, Nai-Ming, Hessmann, Elisabeth, Siveke, Jens, Lahmann, Marlen, Singh, Garima, Voelker, Nadine, Vogt, Sophia, Esposito, Irene, Schmidt, Ansgar, Brendel, Cornelia, Stiewe, Thorsten, Gaedcke, Jochen, Mernberger, Marco, Crawford, Howard C, Bamlet, William R, Zhang, Jin-San, Li, Xiao-Kun, Smyrk, Thomas C, Billadeau, Daniel D, Hebrok, Matthias, Neesse, Albrecht, Koenig, Alexander, and Ellenrieder, Volker

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Biological Sciences, Digestive Diseases, Stem Cell Research - Nonembryonic - Human, Rare Diseases, Stem Cell Research, Cancer, Stem Cell Research - Nonembryonic - Non-Human, Pancreatic Cancer, Genetics, Aetiology, 2.1 Biological and endogenous factors, Animals, Cell Differentiation, Cell Line, Tumor, Epithelial-Mesenchymal Transition, Humans, Mice, MicroRNAs, NFATC Transcription Factors, Pancreatic Neoplasms, SOXB1 Transcription Factors, Tumor Suppressor Protein p53, cellular plasticity, miRNA, NFATc1, p53, Sox2, Information and Computing Sciences, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

In adaptation to oncogenic signals, pancreatic ductal adenocarcinoma (PDAC) cells undergo epithelial-mesenchymal transition (EMT), a process combining tumor cell dedifferentiation with acquisition of stemness features. However, the mechanisms linking oncogene-induced signaling pathways with EMT and stemness remain largely elusive. Here, we uncover the inflammation-induced transcription factor NFATc1 as a central regulator of pancreatic cancer cell plasticity. In particular, we show that NFATc1 drives EMT reprogramming and maintains pancreatic cancer cells in a stem cell-like state through Sox2-dependent transcription of EMT and stemness factors. Intriguingly, NFATc1-Sox2 complex-mediated PDAC dedifferentiation and progression is opposed by antithetical p53-miR200c signaling, and inactivation of the tumor suppressor pathway is essential for tumor dedifferentiation and dissemination both in genetically engineered mouse models (GEMM) and human PDAC. Based on these findings, we propose the existence of a hierarchical signaling network regulating PDAC cell plasticity and suggest that the molecular decision between epithelial cell preservation and conversion into a dedifferentiated cancer stem cell-like phenotype depends on opposing levels of p53 and NFATc1 signaling activities.

Published
2015

75. Optimization of Synthesis Parameters and Superconducting Properties of GdFeAsOF<sub/><sub/><sub/>

Author

Azam, Mohammad, Manasa, Manasa, Zajarniuk, Tatiana, Stelmakh, Svitlana, Cetner, Tomasz, Morawski, Andrzej, Wi'niewski, Andrzej, and Singh, Shiv J.

Abstract

REFeAsO (RE1111; RE: rare earth) belongs to the 1111 family of iron-based superconductors (FBS), which illustrates the enhancement of the superconducting transition (Tc) with smaller radii of RE. However, the synthesis of the 1111 phase with a heavy rare-earth is always challenging. In this paper, we report the optimization of the growth and superconducting properties of F-doped GdFeAsO1-xFx bulks by preparing the samples in a wide temperature range (700–1100 °C) at ambient pressure. The optimized synthesis parameters are concluded based on structural, microstructural, transport, and magnetic measurements. These findings suggest that the optimal conditions for preparing F-doped Gd1111 bulks involve a two-step process at 900 °C for 61 hours at ambient pressure, which is lower than previously reported. The optimized samples have revealed the superconducting transition temperature (Tconset) of 43 K for GdFeAsO0.83F0.17. The first-time reported critical current Jc value for this Gd1111 is observed of the order of 103 A/cm2 at 0 T and 5 K. Our investigation also concluded that highly pure precursors, particularly gadolinium metal, are required to achieve the superconducting properties of F-doped Gd1111. A high growth pressure of 1 GPa reduces the superconducting properties of F-doped Gd1111.

Published
2024
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76. Enhancement of Superconducting Properties of Polycrystalline CaKFe4As4 by High-Pressure Growth

Author

Manasa, Manasa, Azam, Mohammad, Zajarniuk, Tatiana, Diduszko, Ryszard, Cetner, Tomasz, Morawski, Andrzej, Wisniewski, Andrzej, and Singh, Shiv J.

Abstract

High-pressure growth is a unique method to improve the sample quality and size. Here, we have used the high gas pressure and high-temperature synthesis (HP-HTS) method to grow CaKFe4As4 (1144) bulks and investigated their superconducting properties using structural, microstructural, transport, and magnetic studies. The microstructural analysis demonstrates that 1144 samples prepared by HP-HTS have improved the sample density and grain connectivity. The transition temperature $({{T}_c^{onset}})$ of 1144 bulks prepared by HP-HTS is increased up to 35.2 K with a transition width (ΔT) of 1 K, which is remarkably comparable to the reported 1144 single crystal. Additionally, the critical current density (Jc) is enhanced by almost one order of magnitude compared with the parent compound prepared by the conventional synthesis process at ambient pressure (CSP), which could be attributed to the improved sample density and effective pinning centers. Our study demonstrates that the sample quality and superconducting properties of various iron-based superconductors can be enhanced by applying the HP-HTS approach, and further research is demanded in this direction.

Published
2024
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77. Antimony Doping Effect on the Superconducting Properties of SmFeAs(O,F)

Author

Azam, Mohammad, Manasa, Manasa, Zajarniuk, Tatiana, Diduszko, Ryszard, Cetner, Tomasz, Morawski, Andrzej, Wisniewski, Andrzej, and Singh, Shiv J.

Abstract

We report the synthesis and characterization of a series of antimony-doped SmFeAs1-xSbxO0.8F0.2 (x = 0, 0.01, 0.03, 0.05, 0.1, 0.2, and 0.3) bulks to investigate the twin doping effects on the superconducting properties of SmFeAs(O,F) caused by fluorine (F) incorporation at O-site in SmO layer and antimony (Sb) substitution at As-site in the conducting layer (FeAs). Since the antimony (Sb) has a larger size than arsenic (As), the enhancement of lattice parameters has been confirmed by the XRD analysis. Microstructural analysis confirms that Sb-doping leads to a small improvement in the sample density and an increase in the inhomogeneity of the constituent elements, especially at higher Sb-doping levels. The parent compound SmFeAsO0.8F0.2 has shown the superconducting transition (Tc) at ∼54 K, which is systematically reduced with the antimony doping contents (x). Our investigation indicates that the Sb-doped SmFeAs(O,F) phase at low levels is less prone to the multiphase formation than at high levels, which affects the inter- and intragranular behaviour originating from the microstructure nature of 1111 bulks. The critical current density (Jc) of the parent compound has almost the same value as previously reported, which is suppressed slowly with increased Sb-doping. It could be due to the reduced grain connections and the effective pinning centers. This study confirms that the superconducting FeAs layer doping with larger ions at arsenic sites does not support the superconducting properties of Sm1111, which is a distinct behavior from that of Sb-doped CeFeAs(O,F) and LaFeAs(O,F).

Published
2024
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95. An Ultra-Flexible Tactile Sensor Using Silk Piezoelectric Thin Film

Author

Bonam, Satish, Bhagavathi, K. Aditya, Joseph, Jose, Singh, Shiv Govind, and Vanjari, Siva Rama Krishna

Abstract

Tactile sensors are pressure/strain sensors that facilitate the measurement of mechanical stimuli arising from living and nonliving objects to fetch information about their physical state. These systems are of utmost importance in applications such as artificial intelligence, robotic-based prosthetics, and healthcare. To mimic the human nature of touch perception, the flexibility of active sensing material is a critical requirement in the construction of a tactile sensor. Finding a biocompatible, flexible material with moderately high sensitivity is the major hurdle in the development of prosthetic wearable and implantable devices. In this article, we report, for the first time, a silk-based ultra-flexible tactile sensor that draws on the piezoelectric property of silk thin film. The fabrication of the tactile sensor involves only one lithography step and one spin coating step, which makes it easy to be realized in resource-constrained laboratory settings. A systematic analysis is carried out to correlate the performance of the sensor with the properties of silk thin films prepared under different conditions. To assess the potential of the silk-based tactile sensor’s utility in practical applications, the linearity, repeatability, and stability of the fabricated devices are also analyzed. Apart from that, the tactile sensor is attached to different body parts to detect and distinguish various body movements. It is observed that the silk-based tactile sensor could detect different body movements distinctly, stably, and accurately.

Published
2023
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98. Advanced Ceramics for Versatile Interdisciplinary Applications

Author

Singh, Shiv and Singh, Shiv

Abstract

Advanced Ceramics for Versatile Interdisciplinary Applications describes recent progress in ceramic synthesis and their applications in areas of catalysis, lithium-ion batteries, microbial fuel cells, and biomedical applications. Advancements in ceramic syntheses, such as laser additive manufacturing technologies are also discussed, as are developments in magnetic-based, doped and piezoelectric ceramics and their applications. Other sections cover mixed ionic-electronic conducting ceramic membranes for electrochemical applications, ceramic separators for microbial fuel cells, ceramic polymer composites for lithium-ion batteries, and hybrid ceramic nanocomposites for catalysis applications. The use of metal and metal oxide nanostructures as antimicrobial agents offer a wide range of advantages, ranging from straightforward synthesis to less prone towards resistance development by microbes. Finally, the development of biocompatible ceramic materials, mechanical and chemical properties, and applications are discussed in detail. The book will be useful for new researchers, academics and postgraduate students all working in the area of ceramics and their potential applications. Focuses on the optical and electrochemical properties of advanced ceramic materials and MXenes Covers synthesis, characterization techniques and a diverse range of applications, including energy and biomaterials Contains contributions from a diverse range of backgrounds across chemistry, physics, materials science, engineering, medical science, environmental and industrial technology, biotechnology and biomedical engineering

Published
2022

99. 540: DEVELOPMENT OF A COMPUTATIONAL MACHINE LEARNING ESOPHAGEAL ADENOCARCINOMA AND BARRETT'S ESOPHAGUS RISK PREDICTION MODEL FROM A DEIDENTIFIED ELECTRONIC MEDICAL RECORD DATABASE

Author

Iyer, Prasad G., primary, Sachdeva, Karan, additional, Codipilly, Don C., additional, Leggett, Cadman L., additional, Asfahan, Shahir, additional, Awasthi, Samir, additional, Padhye, Chinmay V., additional, Anand, Praveen, additional, Kumar, Praveen, additional, Behera, Kailash C., additional, Singh, Shiv P., additional, Shukla, Sharad, additional, Bade, Sairam, additional, Barve, Rakesh, additional, Thiagarajan, Viswanathan, additional, Mahto, Chandan, additional, Singh, Navjeet, additional, and Yadav, Saurav, additional

Published
2022
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