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805 results on '"Song, Yanling"'

54. Adipose‐Derived Mesenchymal Stem Cell‐Derived Exosomes Biopotentiated Extracellular Matrix Hydrogels Accelerate Diabetic Wound Healing and Skin Regeneration

Author

Song, Yanling, primary, You, Yuchan, additional, Xu, Xinyi, additional, Lu, Jingyi, additional, Huang, Xiajie, additional, Zhang, Jucong, additional, Zhu, Luwen, additional, Hu, Jiahao, additional, Wu, Xiaochuan, additional, Xu, Xiaoling, additional, Tan, Weiqiang, additional, and Du, Yongzhong, additional

Published
2023
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67. μ‐opioid receptor agonist facilitates circulating tumor cell formation in bladder cancer via the MOR/AKT/Slug pathway: a comprehensive study including randomized controlled trial

Author

Wang, Xiaoqiang, primary, Zhang, Song, additional, Jin, Di, additional, Luo, Jiamei, additional, Shi, Yumiao, additional, Zhang, Yiqi, additional, Wu, Lingling, additional, Song, Yanling, additional, Su, Diansan, additional, Pan, Zhiying, additional, Chen, Haige, additional, Cao, Ming, additional, Yang, Chaoyong, additional, Yu, Weifeng, additional, and Tian, Jie, additional

Published
2023
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70. Anti-VEGFR2 F(ab′)2 drug conjugate promotes renal accumulation and glomerular repair in diabetic nephropathy.

Author

Liu, Di, Song, Yanling, Chen, Hui, You, Yuchan, Zhu, Luwen, Zhang, Jucong, Xu, Xinyi, Hu, Jiahao, Huang, Xiajie, Wu, Xiaochuan, Xu, Xiaoling, Jiang, Saiping, and Du, Yongzhong

Abstract

Poor renal distribution of antibody-based drugs is the key factor contributing to low treatment efficiency for renal diseases and side effects. Here, we prepare F(ab′)2 fragmented vascular endothelial growth factor receptor 2 antibody (anti-VEGFR2 (F(ab′)2) to block VEGFR2 overactivation in diabetic nephropathy (DN). We find that the anti-VEGFR2 F(ab′)2 has a higher accumulation in DN male mice kidneys than the intact VEGFR2 antibody, and simultaneously preserves the binding ability to VEGFR2. Furthermore, we develop an antibody fragment drug conjugate, anti-VEGFR2 F(ab′)2-SS31, comprising the anti-VEGFR2 F(ab′)2 fragment linked to the mitochondria-targeted antioxidant peptide SS31. We find that introduction of SS31 potentiates the efficacy of anti-VEGFR2 F(ab′)2. These findings provide proof of concept for the premise that antibody fragment drug conjugate improves renal distribution and merits drug validation in renal disease therapy.Poor renal distribution of antibody-based drugs limits the treatment efficiency for diabetic nephropathy and causes side effects. Here, the authors prepare an antibody fragment drug conjugate, antiVEGFR2 F(ab′)2-SS31, improving renal distribution and meriting drug validation in diabetic nephropathy therapy. [ABSTRACT FROM AUTHOR]

Published
2023
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72. Diverse SARS-CoV-2 aptamers overcome variant antigenic shift.

Author

Huang, Yihao, Zhang, Jialu, Wang, Wencheng, Yang, Chaoyong, and Song, Yanling

Subjects
SARS-CoV-2, SARS-CoV-2 Omicron variant, APTAMERS, EPITOPES, IMMUNOGLOBULINS
Abstract

SARS-CoV-2 mutates rapidly as evidenced by the emergence of Omicron which causes changes in the recognition epitopes of most current neutralizing antibodies and immune evasion. Although aptamers are potential neutralizing agents for SARS-CoV-2 due to their unique molecular properties, it is difficult to compare their performances as assay conditions vary greatly, and their activity levels against variants remain unknown. Here, we evaluated the performances of 14 SARS-CoV-2 aptamers and provided a comprehensive analysis them, which we expect will improve the development of aptamer tools for SARS-CoV-2 diagnostics and therapeutics. [ABSTRACT FROM AUTHOR]

Published
2023
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76. Rapid Point-of-Care Assay by SERS Detection of SARS-CoV-2 Virus and Its Variants

Author

Guan, Peng-Cheng, primary, Zhang, Hong, additional, Li, Zhi-Yong, additional, Xu, Shan-Shan, additional, Sun, Miao, additional, Tian, Xian-Min, additional, Ma, Zhan, additional, Lin, Jia-Sheng, additional, Gu, Man-Man, additional, Wen, Huan, additional, Zhang, Fan-Li, additional, Zhang, Yue-Jiao, additional, Yu, Guang-Jun, additional, Yang, Chaoyong, additional, Wang, Zhan-Xiang, additional, Song, Yanling, additional, and Li, Jian-Feng, additional

Published
2022
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93. Optimal Strategy on Radiation Estimation for Calculating Universal Thermal Climate Index in Tourism Cities of China

Author

Liu, Jiandong, Zhou, Guangsheng, Linderholm, Hans W, Song, Yanling, Liu, De-Li, Shen, Yanbo, Liu, Yanxiang, Du, Jun, Zhou, Guangsheng [0000-0001-6303-1275], Liu, De-Li [0000-0003-2574-1908], and Apollo - University of Cambridge Repository

Subjects
China, thermal comfort, Climate, Health, Toxicology and Mutagenesis, public health, Public Health, Environmental and Occupational Health, Heat Stress Disorders, Tourism, FOS: Economics and business, radiation estimation, Humans, Cities, UTCI calculation
Abstract

The Universal Thermal Climate Index (UTCI) is believed to be a very powerful tool for providing information on human thermal perception in the domain of public health, but the solar radiation as an input variable is difficult to access. Thus, this study aimed to explore the optimal strategy on estimation of solar radiation to increase the accuracy in UTCI calculation, and to identify the spatial and temporal variation in UTCI over China. With daily meteorological data collected in 35 tourism cities in China from 1961 to 2020, two sunshine-based Angstrom and Ogelman models, and two temperature-based Bristow and Hargreaves models, together with neural network and support vector machine-learning methods, were tested against radiation measurements. The results indicated that temperature-based models performed the worst with the lowest NSE and highest RMSE. The machine-learning methods performed better in calibration, but the predictive ability decreased significantly in validation due to big data requirements. In contrast, the sunshine-based Angstrom model performed best with high NSE (Nash–Sutcliffe Efficiency) of 0.84 and low RMSE (Root Mean Square Error) of 35.4 J/m2 s in validation, which resulted in a small RMSE of about 1.2 °C in UTCI calculation. Thus, Angstrom model was selected as the optimal strategy on radiation estimation for UTCI calculation over China. The spatial distribution of UTCI showed that days under no thermal stress were high in tourism cities in central China within a range from 135 to 225 days, while the largest values occurred in Kunming and Lijiang in southwest China. In addition, days under no thermal stress during a year have decreased in most tourism cities of China, which could be attributed to the asymmetric changes in significant decrease in frost days and slightly increase in hot days. However, days under no thermal stress in summer time have indeed decreased, accompanying with increasing days under strong stress, especially in the developed regions such as Yangze River Delta and Zhujiang River Delta. Based on the study, we conclude that UTCI can successfully depict the overall spatial distribution and temporal change of the thermal environments in the tourism cities over China, and can be recommend as an efficient index in the operational services for assessing and predicting thermal perception for public health. However, extreme cold and heat stress in the tourism cities of China were not revealed by UTCI due to mismatch of the daily UTCI with category at hourly scale, which makes it an urgent task to redefine category at daily scale in the next research work.

Published
2022
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