1,065 results on '"Spring, David R."'
Search Results
52. A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of action
53. A quorum-sensing molecule acts as a morphogen controlling gas vesicle organelle biogenesis and adaptive flotation in an enterobacterium
54. Diversity-oriented synthesis of macrocyclic peptidomimetics
55. Targeting a Novel KRAS Binding Site: Application of One-Component Stapling of Small (5–6-mer) Peptides
56. Variations on a theme: diverse N-acyl homoserine lactone-mediated quorum sensing mechanisms in Gram-negative bacteria
57. New Advances in Diversity-Oriented Synthesis
58. Identification of macrocyclic peptides which activate bacterial cylindrical proteasesElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3md00136a
59. Additional file 1 of Microscopy and chemical analyses reveal flavone-based woolly fibres extrude from micron-sized holes in glandular trichomes of Dionysia tapetodes
60. Additional file 3 of Microscopy and chemical analyses reveal flavone-based woolly fibres extrude from micron-sized holes in glandular trichomes of Dionysia tapetodes
61. Additional file 2 of Microscopy and chemical analyses reveal flavone-based woolly fibres extrude from micron-sized holes in glandular trichomes of Dionysia tapetodes
62. Additional file 6 of Microscopy and chemical analyses reveal flavone-based woolly fibres extrude from micron-sized holes in glandular trichomes of Dionysia tapetodes
63. Additional file 5 of Microscopy and chemical analyses reveal flavone-based woolly fibres extrude from micron-sized holes in glandular trichomes of Dionysia tapetodes
64. Additional file 4 of Microscopy and chemical analyses reveal flavone-based woolly fibres extrude from micron-sized holes in glandular trichomes of Dionysia tapetodes
65. Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging strategy.
66. Diversity-Oriented Synthesis: Developing New Chemical Tools to Probe and Modulate Biological Systems
67. Structure-activity analysis of the Pseudomonas quinolone signal molecule
68. Spirocycles as Rigidified sp3-Rich Scaffolds for a Fragment Collection
69. Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study
70. Peptides as a platform for targeted therapeutics for cancer: peptide–drug conjugates (PDCs)
71. Site-selective modification strategies in antibody–drug conjugates
72. Chemical probes targeting the kinase CK2: a journey outside the catalytic box
73. The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions
74. The role of chemical synthesis in developing RiPP antibiotics
75. Rapid and robust cysteine bioconjugation with vinylheteroarenes
76. A dual-enzyme cleavable linker for antibody–drug conjugates
77. Photocatalytic methods for amino acid modification
78. Virulence in Pectobacterium atrosepticum is regulated by a coincidence circuit involving quorum sensing and the stress alarmone, (p)ppGpp
79. Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction
80. Development of a Novel Cell-Permeable Protein-Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1
81. The Basics of Diversity-Oriented Synthesis
82. Metabolic and regulatory engineering of Serratia marcescens: mimicking phage-mediated horizontal acquisition of antibiotic biosynthesis and quorumsensing capacities
83. Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics
84. Formation of flavone-based wooly fibres by glandular trichomes of Dionysia tapetodes
85. Diversity-Oriented Synthesis
86. Communications blackout? Do N-acylhomoserine-lactone-degrading enzymes have any role in quorum sensing?
87. Diversity-Oriented Synthesis
88. An Introduction to Diversity-Oriented Synthesis
89. Diversity-oriented synthesis of biaryl-containing medium rings using a one bed/one stock solution platform
90. The Serratia LuxR family regulator CarR39006 activates transcription independently of cognate quorum sensing signals
91. Drug discovery: A question of library design: Two approaches have emerged for creating libraries of compounds for use in biological screening assays for drug discovery — fragment-based ligand design and diversity-oriented synthesis. Advocates of each approach discuss their favoured strategy.
92. Divergent Synthesis of Novel Cylindrocyclophanes that Inhibit Methicillin‐Resistant Staphylococcus aureus (MRSA)
93. Hydroxylated Rotenoids Selectively Inhibit the Proliferation of Prostate Cancer Cells
94. 2-Aminopyridine Analogs Inhibit Both Enzymes of the Glyoxylate Shunt in Pseudomonas aeruginosa
95. Hotspots API: A Python Package for the Detection of Small Molecule Binding Hotspots and Application to Structure-Based Drug Design
96. Functionalized Double Strain-Promoted Stapled Peptides for Inhibiting the p53-MDM2 Interaction
97. Efficient and selective antibody modification with functionalised divinyltriazines
98. Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion
99. Sulfatase-cleavable linkers for antibody-drug conjugates
100. General dual functionalisation of biomacromolecules via a cysteine bridging strategy
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