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60. Topical application of cannabinoid-ligands ameliorates experimental dry-eye disease

Author

Tran, Bao N., Maass, Martina, Musial, Gwen, Stern, Michael E., Gehlsen, Uta, and Steven, Philipp

Abstract

Dry eye disease (DED) is a multifactorial disease, with limitations regarding efficacy and tolerability of applied substances. Among several candidates, the endocannabinoid system with its receptors (CB1R and CB2R) were reported to modulate inflammation, wound healing and pain, which are also core DED pathomechanisms. This study is to investigate the therapeutic responses of Δ-9 tetrahydrocannabinol (a non-selective agonist) and two selective antagonists, SR141716A (CB1R antagonist) and SR144528 (CB2R antagonist), as a topical application using a DED mouse model.

Published
2022
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62. A Clinical Phase II Study to Assess Efficacy, Safety, and Tolerability of Waterfree Cyclosporine Formulation for Treatment of Dry Eye Disease

Author

Wirta, David L., primary, Torkildsen, Gail L., additional, Moreira, Helen R., additional, Lonsdale, John D., additional, Ciolino, Joseph B., additional, Jentsch, Garrit, additional, Beckert, Michael, additional, Ousler, George W., additional, Steven, Philipp, additional, and Krösser, Sonja, additional

Published
2019
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65. Tolerance and Adherence to Cationic 0.1% Cyclosporine in Ocular Graft-versus-Host Disease.

Author

Gehlsen, Uta, Siebelmann, Sebastian, and Steven, Philipp

Abstract

Introduction: Anti-inflammatory, topical therapy of severe keratitis in dry eye disease (DED) and ocular graft-versus-host disease (oGvHD) includes steroids, cyclosporine (Cs), and others. In Germany, a commercial product containing 0.1% Cs in a cationic formulation is available since 2015. Objective: The aim of this study was to present real-life data using cationic 0.1% Cs in oGvHD patients. Methods: This was a retrospective study of 26 oGvHD and 41 DED patients with corneal staining of at least Oxford grade III. Parameters analyzed were Ocular Surface Disease Index, corneal staining, intraocular pressure, tear film break-up time, Schirmer, and visual acuity. In addition, it was evaluated how different Cs formulations were tolerated. Results: Corneal staining improved significantly in 1 eye in DED but not in oGvHD. In DED, cationic 0.1% Cs was not tolerated by 32% of the patients, in contrast to 0.05% Cs in castor oil not tolerated by 47% and liposomal 0.05% Cs by 63%. In oGvHD patients, cationic 0.1% Cs was not tolerated by 62%, 0.05% Cs in castor oil by 33%, and liposomal 0.05% Cs by 39% of the patients. Conclusions: This study demonstrates differences between the tolerance of different Cs formulations depending on the underlying cause of severe keratitis. Cationic 0.1% Cs is considerably less tolerated in oGvHD, and its use should be considered with care. [ABSTRACT FROM AUTHOR]

Published
2021
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68. Semifluorinated Alkane Eye Drops in Chronic Ocular Graft-versus-Host Disease: A Prospective, Multicenter, Noninterventional Study.

Author

Eberwein, Philipp, Krösser, Sonja, and Steven, Philipp

Subjects
GRAFT versus host disease, EYE drops, HEMATOPOIETIC stem cell transplantation, DRY eye syndromes, ALKANES, EYE diseases
Abstract

Purpose: Ocular graft-versus-host disease (oGvHD) following allogeneic hematopoietic stem cell transplantation develops as severe dry eye disease (DED) and is initially treated with lubricants, although no clinical trials are available using artificial tears in oGvHD. This trial was set up to test perfluorohexyloctane (NovaTears®) as nonpreserved layer-forming agent for the treatment of DED in oGvHD. Methods: 25 patients with severe DED due to oGvHD received 1 drop perfluorohexyloctane 4 times daily during a prospective, multicenter, observational 12-week study on top of established topical therapy. Clinical parameters included Schirmer test, tear film breakup time, corneal staining, meibum secretion and ocular surface disease index. Adverse events, visual acuity and intraocular pressure were key safety parameters. Results: From 25 patients recruited, 23 presented for the second visit. Perfluorohexyloctane treatment did not lead to any changes in clinical or safety parameters but led to fast relief in symptoms in 57% of the patients. One adverse reaction occurred. Conclusions: This study showed no change in clinical signs in severe DED due to oGvHD, which was not unexpected due to the underlying pathomechanisms. However, the study showed improvement of symptoms in individual patients allowing application of perfluorohexyloctane as an additional symptomatic therapy in oGvHD. [ABSTRACT FROM AUTHOR]

Published
2020
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71. Semifluorinated Alkane Eye Drops for Treatment of Dry Eye Disease Due to Meibomian Gland Disease

Author

Steven, Philipp, primary, Augustin, Albert J., additional, Geerling, Gerd, additional, Kaercher, Thomas, additional, Kretz, Florian, additional, Kunert, Kathleen, additional, Menzel-Severing, Johannes, additional, Schrage, Norbert, additional, Schrems, Wolfgang, additional, Krösser, Sonja, additional, Beckert, Michael, additional, and Messmer, Elisabeth M., additional

Published
2017
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74. Neue Therapieansätze bei entzündlichen Augenerkrankungen durch Modulation von Lymphangiogenese und zellulärer Immunität: Die DFG-Forschergruppe 2240 stellt sich vor

Author

Cursiefen, Claus, additional, Bock, Felix, additional, Clahsen, Thomas, additional, Regenfuss, Birgit, additional, Reis, Andre, additional, Steven, Philipp, additional, Heindl, Ludwig, additional, Bosch, Jacobus, additional, Hos, Deniz, additional, Eming, Sabine, additional, Grajewski, Rafael, additional, Heiligenhaus, Arnd, additional, Fauser, Sascha, additional, Austin, Jennifer, additional, and Langmann, Thomas, additional

Published
2017
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76. Gender-Based Service Preferences of Spa-Goers

Author

Steven Philipp, Candice Clemenz, and Linda Sherman

Subjects
Gerontology, Service (business), Reflexology, Massage, medicine.medical_treatment, medicine, Pedicure, Shiatsu, Hydrotherapy, Psychology, Aromatherapy, Nutritional counseling
Abstract

An emerging male market within the spa industry is causing practitioners to consider if men and women differ in their service preferences at spas. This study explored the question via a self-administered survey instrument distributed to individuals located in resort communities along the Gulf Coast of the Florida panhandle. Analysis of the responses of 107 subjects indicated significant gender differences on the importance ratings of 12 out of 18 common spa services: aromatherapy, body scrub and exfoliation, facial, fitness facilities, lymph drainage, manicure, mud or seaweed wrap, pedicure, Pilates, Shiatsu, sport massage, and yoga. The services that men and women rated similarly in decreasing order of importance were Swedish massage, nutritional counseling, steam and sauna, hydrotherapy, spa cuisine, and reflexology.

Published
2007

77. Activated CD4+T cells enter the splenic T-cell zone and induce autoantibody-producing germinal centers through bystander activation

Author

Banczyk, David, Kalies, Kathrin, Nachbar, Lars, Bergmann, Lars, Schmidt, Philipp, Bode, Ulrike, Teegen, Bianca, Steven, Philipp, Lange, Tanja, Textor, Johannes, Ralf Ludwig, Stoecker, Winfried, Koenig, Peter, Bell, Eric, Westermann, Juergen, and Sub Theoretical Biology

Subjects
cross linking, Noncognate interaction, adoptive transfer, in vitro study, memory T lymphocyte, animal cell, Development, lymphocyte proliferation, T lymphocyte activation, male, T lymphocyte, controlled study, rat, lymphocyte migration, cellular distribution, mouse, B lymphocyte activation, CD4+ T lymphocyte, Rodent, nonhuman, B lymphocyte, T lymphocyte subpopulation, article, Germinal center, priority journal, CD28 antigen, bystander effect, antigen expression, Activated T cells, CD40 ligand, T lymphocyte receptor, CD4 antigen, autoantibody, spleen cell, thoracic duct
Abstract

CD4+T (helper) cells migrate in huge numbers through lymphoid organs. However, little is known about traffic routes and kinetics of CD4+T-cell subsets within different organ compartments. Such information is important because there are indications that CD4+T cells may influence the function of microenvironments depending on their developmental stage. Therefore, we investigated the migration of resting (naïve), activated, and recently activated (memory) CD4+T cells through the different compartments of the spleen. Resting and recently activated CD4+T cells were separated from thoracic duct lymph and activated CD4+T cells were generated in vitro by cross-linking the T-cell receptor and CD28. The present study shows that all three CD4+T-cell subsets selectively accumulate in the T-cell zone of the spleen. However, only activated T cells induce the formation of germinal centers (GCs) and autoantibodies in rats and mice. Our results suggest that in a two-step process they first activate B cells independent of the T-cell receptor repertoire and CD40 ligand (CD154) expression. The activated B cells then form GCs whereby CD154-dependend T-cell help is needed. Thus, activated T cells may contribute to the development of autoimmune diseases by activating autoreactive B cells in an Ag-independent manner. European Journal of Immunology published by Wiley-VCH Verlag GmbH & Co. KGaA Weinheim.

Published
2014

78. Treatment of severe chronic ocular graft-versus-host disease using 100% autologous serum eye drops from a sealed manufacturing system: a retrospective cohort study

Author

Tahmaz, Volkan, primary, Gehlsen, Uta, additional, Sauerbier, Laura, additional, Holtick, Udo, additional, Engel, Lisa, additional, Radojska, Stela, additional, Petrescu-Jipa, Viorica-Maria, additional, Scheid, Christof, additional, Hallek, Michael, additional, Gathof, Birgit, additional, Cursiefen, Claus, additional, and Steven, Philipp, additional

Published
2016
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85. Activated CD4+ T cells enter the splenic T-cell zone and induce autoantibody-producing germinal centers through bystander activation

Author

Banczyk, David, Kalies, Kathrin, Nachbar, Lars, Bergmann, Lars, Schmidt, Philipp, Bode, Ulrike, Teegen, Bianca, Steven, Philipp, Lange, Tanja, Textor, Johannes, Ludwig, Ralf J., Stöcker, Winfried, König, Peter, Bell, Eric, Westermann, Jürgen, and Sub Theoretical Biology

Subjects
CD4-Positive T-Lymphocytes, Male, animal cell, Lymphocyte Activation, Interleukin 21, Mice, T-Lymphocyte Subsets, T lymphocyte, Immunology and Allergy, Cytotoxic T cell, rat, lymphocyte migration, IL-2 receptor, CD154, cellular distribution, Cells, Cultured, Mice, Knockout, B lymphocyte activation, Mice, Inbred BALB C, Rodent, T lymphocyte subpopulation, biology, ZAP70, article, Adoptive Transfer, Cell biology, medicine.anatomical_structure, priority journal, Activated T cells, CD4 antigen, cross linking, in vitro study, Noncognate interaction, T cell, Immunology, CD40 Ligand, memory T lymphocyte, lymphocyte proliferation, Development, T lymphocyte activation, medicine, Animals, controlled study, Antigen-presenting cell, mouse, Autoantibodies, CD4+ T lymphocyte, nonhuman, CD40, B lymphocyte, Germinal center, Bystander Effect, Rats, Mice, Inbred C57BL, Rats, Inbred Lew, CD28 antigen, biology.protein, antigen expression, Cellular Immune Response, T lymphocyte receptor, Immunologic Memory, autoantibody, Spleen, spleen cell, thoracic duct
Abstract

CD4+T (helper) cells migrate in huge numbers through lymphoid organs. However, little is known about traffic routes and kinetics of CD4+T-cell subsets within different organ compartments. Such information is important because there are indications that CD4+T cells may influence the function of microenvironments depending on their developmental stage. Therefore, we investigated the migration of resting (naïve), activated, and recently activated (memory) CD4+T cells through the different compartments of the spleen. Resting and recently activated CD4+T cells were separated from thoracic duct lymph and activated CD4+T cells were generated in vitro by cross-linking the T-cell receptor and CD28. The present study shows that all three CD4+T-cell subsets selectively accumulate in the T-cell zone of the spleen. However, only activated T cells induce the formation of germinal centers (GCs) and autoantibodies in rats and mice. Our results suggest that in a two-step process they first activate B cells independent of the T-cell receptor repertoire and CD40 ligand (CD154) expression. The activated B cells then form GCs whereby CD154-dependend T-cell help is needed. Thus, activated T cells may contribute to the development of autoimmune diseases by activating autoreactive B cells in an Ag-independent manner. European Journal of Immunology published by Wiley-VCH Verlag GmbH & Co. KGaA Weinheim.

Published
2013

95. Activated CD4 + T cells enter the splenic T‐cell zone and induce autoantibody‐producing germinal centers through bystander activation

Author

Banczyk, David, primary, Kalies, Kathrin, additional, Nachbar, Lars, additional, Bergmann, Lars, additional, Schmidt, Philipp, additional, Bode, Ulrike, additional, Teegen, Bianca, additional, Steven, Philipp, additional, Lange, Tanja, additional, Textor, Johannes, additional, Ludwig, Ralf J., additional, Stöcker, Winfried, additional, König, Peter, additional, Bell, Eric, additional, and Westermann, Jürgen, additional

Published
2013
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99. Future Prospects: Assessment of Intraoperative Optical Coherence Tomography in Ab Interno Glaucoma Surgery.

Author

Heindl, Ludwig M., Siebelmann, Sebastian, Dietlein, Thomas, Hüttmann, Gereon, Lankenau, Eva, Cursiefen, Claus, and Steven, Philipp

Subjects
OPTICAL coherence tomography, GLAUCOMA surgery, INTRAOCULAR pressure, INTRAOPERATIVE monitoring, VISUALIZATION
Abstract

Purpose:Ab internoglaucoma surgery, such as trabecular aspiration orab internotrabeculotomy, has been introduced as an alternative, non-filtering procedure to lower intraocular pressure in glaucoma patients. The purpose of the present study was to assess the feasibility of intraoperative spectral domain optical coherence tomography (iOCT) for improvingab internoglaucoma surgery. Materials and Methods: Intraoperative optical coherence tomography was performed to visualize the anterior chamber angle, the aspiration canula during trabecular aspiration, and the trabectome device duringab internotrabeculotomy. A commercially available 840-nm iOCT was used in a clinical setting, a 1310-nm spectral-domain OCT in an experimental setting. Results: In the clinical setting using the 840-nm iOCT, visualization of the aspiration canula and the trabectome device was possible, however, with rather limited visibility of the chamber angle and the trabecular meshwork. In the experimental setting, the 1310-nm OCT enabled excellent visualization of the chamber angle and detailed evaluation of the instrument–trabecular meshwork relation. Conclusions: Intraoperative use of optical coherence tomography may be helpful forab internoglaucoma surgery. Adjustments of the commercially available iOCT, including longer wavelengths and oblique scanning options, are necessary for the clinical use. [ABSTRACT FROM PUBLISHER]

Published
2015
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