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51. Survival following Pulmonary Metastasectomy for Sarcoma

Author

Okiror, Lawrence, primary, Peleki, Aikaterini, primary, Moffat, Daniel, primary, Bille, Andrea, primary, Bishay, Ehab, primary, Rajesh, Pala, primary, Steyn, Richard, primary, Naidu, Babu, primary, Grimer, Robert, primary, and Kalkat, Maninder, additional

Published
2015
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57. Pulmonary rehabilitation programme for patients undergoing curative lung cancer surgery

Author

Bradley, Amy, primary, Marshall, Andrea, additional, Stonehewer, Louisa, additional, Reaper, Lynn, additional, Parker, Kim, additional, Bevan-Smith, Elaine, additional, Jordan, Chris, additional, Gillies, James, additional, Agostini, Paula, additional, Bishay, Ehab, additional, Kalkat, Maninder, additional, Steyn, Richard, additional, Rajesh, Pala, additional, Dunn, Janet, additional, and Naidu, Babu, additional

Published
2013
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58. The pre-hospital management of life-threatening chest injuries: A consensus statement from the Faculty of Pre-Hospital Care, Royal College of Surgeons of Edinburgh.

Author

Leech, Caroline, Porter, Keith, Steyn, Richard, Laird, Colville, Virgo, Imogen, Bowman, Richard, and Cooper, David

Subjects
CATASTROPHIC illness, CHEST injuries, CONSENSUS (Social sciences), EMERGENCY medicine, HOSPITAL emergency services, MEDICAL protocols, PNEUMOTHORAX, THORACOSTOMY, SURGERY, THERAPEUTICS
Abstract

‘The pre-hospital management of chest injury: a consensus statement’ was originally published by the Faculty of Pre-hospital Care, Royal College of Surgeons of Edinburgh in 2007. To update the pre-existing guideline, a consensus meeting of stakeholders was held by the Faculty of Pre-hospital Care in Coventry in November 2013. This paper provides a guideline for the pre-hospital management of patients with the life-threatening chest injuries of tension pneumothorax, open pneumothorax, massive haemothorax, flail chest (including multiple rib fractures), and cardiac tamponade. [ABSTRACT FROM AUTHOR]

Published
2017
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59. Hani: A Life Too Short

Author

Steyn, Richard

Subjects
Hani: A Life Too Short (Biography) -- Tromp, Beauregard -- Smith, Janet -- Book reviews, Books -- Book reviews, Humanities
Abstract

Hani: A Life Too Short. Janet Smith and Beauregard Tromp. Johannesburg: Jonathan Ball, 2009. 338 pp. R190. The enduring 'what if' of South African history is: what if Chris Hani [...]

Published
2011

67. Book reviews

Author

Steyn, Richard, primary, Wheeler, Thomas, additional, Gruzd, Steven, additional, and Shillinger, Kurt, additional

Published
2007
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73. The transition process and the South African media

Author

Steyn, Richard

Subjects
South Africa -- Social aspects, Mass media -- Political aspects, Business, Publishing industry
Abstract

The transition from apartheid to a free and democratic society has created problems for the South African media. First, the media reflects the minority-dominated society which created it and which is now undergoing radical changes. Other problems include how to treat the African National Conference and the South African Communist Party, how to contend with political violence against journalists and how to address a public weary of negative news., IT IS ALWAYS difficult for those who live through cataclysmic change to retain perspective and take a long-term view. We constantly have to remind ourselves that we are in the [...]

Published
1994

75. Letters.

Author

Himmelstein, David U, Woolhandler, Steffie, David, David S, Edwards, Nigel, Schuur, Jeremiah D, Robson, John, McIlwain, Colin A, Bene, Julian M, Tonks, Alison, Newman, Laura, Reinhardt, Uwe E, Rogers, Hugh, Warner, Jenny, Steyn, Richard, Silvester, Kate, Pepperman, Mike, Nash, Roddy, Castille, Karen, and Gowland, Ben

Subjects
LETTERS to the editor, MEDICAL care costs, HUMAN artificial insemination
Abstract

Presents letters to the editor of this journal. The cost of medical care under Kaiser Permanente in the United States and the National Health Service in Great Britain; Topics of measures to reduce smoking in films, health policies on drug dependence, winter mortality, income inequality and health, booked inpatient admissions and hospital capacity, American health care, and compliance aids in medicine; Discussion of being a child of donor insemination.

Published
2002

76. Selective accumulation of virus-specific CD8+T cells with unique homing phenotype within the human bone marrow

Author

Palendira, Umaimainthan, Chinn, Rosanna, Raza, Wajid, Piper, Karen, Pratt, Guy, Machado, Lee, Bell, Andrew, Khan, Naeem, Hislop, Andrew D., Steyn, Richard, Rickinson, Alan B., Buckley, Christopher D., and Moss, Paul

Abstract

The bone marrow plays a unique role within the immune system. We compared the phenotype and function of virus-specific CD8+T cells from matched samples of human peripheral blood and bone marrow. Analysis of virus-specific memory CD8+T cells showed widely divergent partition of antigen-specific populations between blood and bone marrow. T cells specific for Epstein-Barr virus (EBV) lytic antigens were enriched 3-fold in marrow compared with blood, whereas the response to EBV latent epitopes was equivalent between the 2 compartments. No difference in EBV viral load or expression of the EBV lytic protein was observed between blood and bone marrow. In direct contrast, although cytomegalo-virus (CMV)–specific T cells were the largest virus-specific population within peripheral blood, they were reduced by 60% within marrow. Bone marrow T cells were found to exhibit a unique CCR5+CXCR6+CXCR3−homing phenotype which has not been observed on T cells from other secondary lymphoid organs or peripheral organs. Expression of CCR5 and CXCR6 was higher on EBV-specific T cells within peripheral blood compared with CMV-specific populations. These observations identify a novel bone marrow homing phenotype for CD8+memory T cells, which necessitates a reevaluation of the magnitude of antigen-specific populations within the lymphoid system.

Published
2008
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77. Management of complicated postoperative air-leak - a new indication for the Asherman chest seal.

Author

Rathinam, Sridhar and Steyn, Richard S

Abstract

Postoperative air-leak is a problem which is frequently encountered in thoracic surgery. We describe the utility of the Asherman chest seal, a device used in primary trauma care in the successful management of a complicated postoperative air-leak. The Asherman Chest Seal is a sterile occlusive dressing with a one-way Heimlich valve for treating open pneumothorax in acute settings. We used the Asherman chest seal in six patients from July 2001-June 2006 for management of persistent air-leak following thoracic surgical procedures. It was used in three decortication and three pleurectomy patients. There was an equal sex distribution with an age range of 24-67 years. The chest seal was used when drains fell out in the presence of air-leak or wound infection resulting in pneumothorax. All six patients had satisfactory expansion of the lungs with cessation of the air-leak. This was achieved without the pain and morbidity of a chest drain and inpatient stay. The Asherman chest seal is a simple but very useful device that has a role in management of complex air-leaks.

Published
2007
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78. Pectus patient information website has improved access to care and patient reported outcomes

Author

Tikka, Theofano, Webb, Joanne, Agostini, Paula, Kerr, Amy, Mannion, Glenn, Steyn, Richard S, Bishay, Ehab, Kalkat, Maninder S, Rajesh, Pala B, and Naidu, Babu

Subjects
Male, Internet, Adolescent, Thoracic Surgical Procedures, Patient Outcome Assessment, Young Adult, Patient Education as Topic, Information, Funnel Chest, Surveys and Questionnaires, Humans, Female, Surgery, Pectus website, Cardiology and Cardiovascular Medicine, RA, Research Article
Abstract

BACKGROUND: Pectus is the most common congenital disorder. Awareness amongst primary care physicians and the general public is poor. NHS commissioning bodies plan to withdraw funding for this surgery because they deem a lack of sufficient evidence of benefit. The purpose of this study is to assess the effects of introducing a patient information website on referral and activity patterns and on patients reported outcomes. METHODS: We produced an innovative information website, www.pectus.co.uk , accessible to the general public, providing information about pectus deformities; management options and advice about surgery. Referral patterns and number of cases where studied before and after the introduction of the website in 2010. Patients' satisfaction post-op was assessed using the Brompton's single step questionnaire (SSQ). RESULTS: The website had considerable traffic with 2179 hits in 2012, 4983 in 2013 and 7416 in 2014. This has led to 1421 contacts and 372 email enquiries. These emails have resulted in an increased number of patients who have been assessed and go on to have surgery. We asked 59 pectus excavatum patients who were operated from 2008 to 2014 to complete the SSQ. We received 32 replies. Eighty-four percent (16/19) of patients who visited the website and then underwent surgery, found the website useful. All patients scored satisfactorily in SSQ. Even though those who visited the website tended to be more satisfied with the surgical outcomes this did not reach statistical significance. This group of patients said that would have the operation again given the option compared to 76.9 % of the group who did not visit the website before surgery (p=0.031). Despite the fact that patients who visited the website experienced more post-operative complications were equally or more satisfied with post-operative outcomes. The overall SSQ obtainable score was not different for the two subgroups, being more widespread in the group that did not visit the website. CONCLUSIONS: The introduction of a pectus patient information website has significantly improved access to specialised services. Patients are overall highly satisfied with the surgical outcomes.

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79. South Africa's press - no threats, for now

Author

Steyn, Richard

Subjects
South Africa -- Media coverage, Freedom of the press -- Africa, Business, Literature/writing, Mass communications
Abstract

No serious threats to South Africa's press freedom exist so far. A year after the 1994 elections, Nelson Mandela's South African government is more concerned with issues that require more immediate attention than press freedom. Editors and publishers in the country have also given more priority to the business aspects of their profession as South Africans appear to show interest in the abundant supply of foreign and specialist publications, TV and radio programs and home entertainment.

Published
1995

80. We must not take freedom for granted

Author

Steyn, Richard

Subjects
South Africa -- Social aspects, Government and the press -- Analysis, Freedom of the press -- Analysis, Business, Literature/writing, Mass communications
Abstract

The advent of democracy in South Africa will herald a free media in the country. It is essential for the International Press Institute and other organizations to maintain freedom of expression and ensure a free media in South Africa. Journalists have been harassed for long and there should be an end to it to enable the country to prosper.

Published
1994

82. Russia redefined.

Author

Steyn, Richard

Abstract

Presents an interview with Gerrit Olivier, South African ambassador to Moscow in Russia. Includes queries on impressions about Moscow; Queries on the Russian legal system; Queries on threats to the stability of Russia; Queries on the political parties in Russia; Queries on the state of South African-Russian trade relations; Queries about Russia's future.

Published
1995

84. Zuma: A Biography.

Author

Hughes, Tim, Steyn, Richard, and Kendal, Rebekah

Subjects
*NONFICTION
Abstract

The article reviews the book "Zuma: A Biography," by Jeremy Gordin.

Published
2010

85. Delayed haemoptysis from explosive device fragments.

Author

McDonald Johnston, Andrew, West, Andrew T., Kendrew, Jonathan M., Steyn, Richard S., Kalkat, Maninder S., and Graham, Tim R.

Subjects
*DISEASES in military personnel, *EXPLOSIVES, *CHEST injuries, *RADIOLOGY, *REHABILITATION
Abstract

The article focuses on the case of a 32 year old male soldier who is suffering from haemoptysis after he was injured by an improvised explosive device in Afghanistan. On his diagnosis upon the accident, he was diagnosed hypoxic and hypotensive with radiological evidence of massive right sided haemothorax. Bronchospic extraction was done to address the haemoptysis, which proved unsuccessful, but was later removed after incising overlying lung tissue, where stones were recovered.

Published
2013
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86. Cytoplasmic beta-catenin accumulation is a good prognostic marker in upper and lower gastrointestinal adenocarcinomas.

Author

Norwood MG, Bailey N, Nanji M, Gillies RS, Nicholson A, Ubhi S, Darnton JJ, Steyn RS, Womack C, Hughes A, Hemingway D, Harrison R, Waters R, and Jankowski JA

Subjects
Adenocarcinoma pathology, Colorectal Neoplasms metabolism, Colorectal Neoplasms pathology, Cytoplasm metabolism, Esophageal Neoplasms metabolism, Esophageal Neoplasms pathology, Gastrointestinal Neoplasms pathology, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Multivariate Analysis, Neoplasm Staging, Prognosis, Retrospective Studies, Adenocarcinoma metabolism, Biomarkers, Tumor metabolism, Gastrointestinal Neoplasms metabolism, beta Catenin metabolism
Abstract

Aims: beta-Catenin is an important molecule in cancer biology. Membranous beta-catenin enhances cellular differentiation and inhibits invasion by its action on E-cadherin. The aim was to ascertain whether the cellular expression of these molecules in colorectal and oesophageal cancer specimens is associated with survival in patients with gastrointestinal cancer., Methods and Results: Tumour samples from 149 patients undergoing resection for colorectal adenocarcinoma and 147 patients undergoing resection for oesophageal adenocarcinoma were retrospectively analysed using immunohistochemical techniques to assess beta-catenin expression. Increasing beta-catenin expression in the cytoplasm was associated with improved survival for colorectal cancer cases on both univariate (P = 0.003) and multivariate (P = 0.01) analysis. In addition, increased expression in the most recent cohort of oesophageal adenocarcinoma patients was associated with improved TNM staging (P = 0.007). Membrane expression was weakly associated with survival in colorectal cancer on univariate analysis (P = 0.09), but not on multivariate analysis (P = 0.21). Complete absence of beta-catenin expression at all three sites was associated with reduced 5-year survival in colorectal cancer., Conclusions: This is one of the largest prognostic studies of beta-catenin in gastrointestinal adenocarcinoma. It shows that low levels of cytoplasmic beta-catenin expression are associated with reduced survival in patients with colorectal cancer as well as worse TNM staging in oesophageal adenocarcinoma (a recognized surrogate end-point for survival). We believe this is the first time that this has been reported. This finding should be tested prospectively in oncological trials to validate whether the presence of cytoplasmic beta-catenin could be used as a prognostic marker for less aggressive disease.

Published
2010
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87. Needle thoracostomy in treatment of a tension pneumothorax in trauma patients.

Author

Rathinam S, Bleetman A, and Steyn RS

Subjects
Decompression, Surgical instrumentation, Decompression, Surgical methods, Equipment Design, Equipment Safety, Humans, Needles, Pneumothorax diagnostic imaging, Pneumothorax etiology, Pressure, Sensitivity and Specificity, Severity of Illness Index, Thoracostomy methods, Tomography, X-Ray Computed, Treatment Outcome, Wounds and Injuries diagnosis, Pneumothorax surgery, Thoracostomy instrumentation, Wounds and Injuries complications
Published
2008
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88. Booked inpatient admissions and hospital capacity. Mathematical model misses the point.

Author

Rogers H, Warner J, Steyn R, Silvester K, Pepperman M, and Nash R

Subjects
Models, Statistical, United Kingdom, Hospital Bed Capacity statistics & numerical data, Hospitals, Public statistics & numerical data, Length of Stay statistics & numerical data, Patient Admission statistics & numerical data, State Medicine organization & administration
Published
2002

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