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Traditional financial risk detection methods are mainly based on statistical models and market data, in which sensor network has a wide application prospect. The research can improve the accuracy and efficiency of financial risk detection by using the data and information of sensor network. By making full use of the data collection capabilities of sensor networks to obtain more comprehensive and accurate financial data, it helps to identify potential risk factors more accurately. This paper introduces DTW (Dynamic Time warping) algorithm as the main financial risk detection method, which can effectively capture the similarity between time series data and apply it to the financial data obtained by sensor network. Through regularization and matching of time series data, abnormal changes and abnormal patterns can be identified, so as to timely warn and control financial risks. By comparing the data of sensor network with that of traditional methods, we found that the financial risk detection method based on DTW algorithm and sensor network has higher accuracy and efficiency, and can identify potential risk factors more accurately.

This article aims to analyse the complex relationship between religion and politics by exploring collective identities in an increasingly polarised global context. The methodology used is qualitative, with a systematic literature review approach. Data collection techniques included a literature review, utilising more than a thousand previous studies related to politics and religion, as well as secondary data sources, including books, scholarly articles, and reportage. Data analysis involved data condensation, data presentation, and conclusion drawing. The results revealed that the interaction between religion and politics is often symbiotic, where religion can strengthen political legitimacy. Conversely, politics can intensify the integration or marginalisation of religion in society. In the context of Qur'anic literature, analyses show that this sacred text provides relevant guidance for political thought and practice in Muslim societies, putting forward principles such as justice, consultation and the protection of human rights. Furthermore, in understanding the characteristics and objectives of Siyasah (politics) in the Qur'an, it is found that Islamic shari'a directs fair and effective governance, strengthening social relations and justice. This research provides important insights for policymakers and religious leaders to formulate strategies that promote cooperation, tolerance and peace among different religious and political groups.

Abstract Objectives Special needs dentistry (SND) is a vast and fragmented field of study. This comprehensive bibliometric analysis aimed to evaluate the scope of SND, including the existing knowledge base, distribution structure, quantitative relationships, and research trends. Material and Methods A systematic search was conducted on March 10, 2022, using the Web of Science Core Collection database, covering the period from 1985 to 2021, focusing on studies reporting on special needs populations in a dentally relevant context. Records were title‐screened and analyzed for key bibliometric indicators. Results Among 48,374 articles, 13,869 underwent bibliometric analysis. Peak SND research occurred during 1985–1997. United States led in productivity, trailed by Brazil and Japan. University of Sao Paulo excelled in Brazil, University of Washington and University of North Carolina in the United States. The Journal of Dental Research was the most productive source of research and also had the highest number of citations, followed by Community Dentistry and Oral Epidemiology. Keyword analysis revealed that “elderly”, “caries”, and “epidemiology” were the most commonly used author keywords. Conclusions This study represents the first bibliometric analysis of SND literature. It emphasizes the need for increased collaboration between institutions and authors. Furthermore, it suggests focusing on research input from non‐dental disciplines and populations with rarer intellectual or developmental conditions.

Aim To assess machine-learning models, their methodological quality, compare their performance, and highlight their limitations. Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations were applied. Electronic databases Science Direct, MEDLINE through (PubMed, Google Scholar), EBSCO, ERIC, and CINAHL were searched for the period of January 2016 to September 2023. Using a pre-designed data extraction sheet, the review data were extracted. Big data, risk assessment, colorectal cancer, and artificial intelligence were the main terms. Results Fifteen studies were included. A total of 3,057,329 colorectal cancer (CRC) health records, including those of adult patients older than 18, were used to generate the results. The curve's area under the curve ranged from 0.704 to 0.976. Logistic regression, random forests, and colon flag were often employed techniques. Overall, these trials provide a considerable and accurate CRC risk prediction. Conclusion An up-to-date summary of recent research on the use of big data in CRC prediction was given. Future research can be facilitated by the review's identification of gaps in the literature. Missing data, a lack of external validation, and the diversity of machine learning algorithms are the current obstacles. Despite having a sound mathematical definition, area under the curve application depends on the modelling context.

New technologies drive educational shifts, transforming offline to online learning. This study investigates e-learning and cloud computing integration to understand synergies and their potential impact. The study addresses two primary research questions: the influence of e-learning on factors like architecture, software, performance, security, hardware, network, and virtual aspects, and the examination of cloud computing services and models such as SaaS, PaaS, IaaS, and S.O.A. The research aims to provide insights into how e-learning is incorporated in a cloud computing environment. The motivation behind this study is to investigate the intricate relationship between e-learning and cloud computing. By analyzing 154 scientific papers, the study delves into the specifics of this integration, highlighting trends and areas that have received more attention. The study examines e-learning in a cloud computing environment, focusing on architecture (27%), general topics (21%), software (19%), and performance (18%). Virtual environments have fewer security issues, while storage and network focus are more prevalent. Cloud computing services are mainly all services, with software as a service (18%), infrastructure as a service (17%), and platforms as a service (10%). Most studies are based on public clouds (74%), all other models (11%), and hybrid clouds (3%). The study examines e-learning integration in cloud computing, highlighting limitations in hybrid and private clouds, specialized infrastructure, and a gap in platforms and infrastructure offerings.

Abstract Introduction and aims Many studies have investigated the relationship between social support and the prevention of elder abuse; however, their results are somehow inconsistent in terms of the association. This systematic review and meta-analysis aimed to investigate the published studies on the relationship between social support and the prevention of elder maltreatment. Materials and methods An electronic search was conducted until January 2023, using such databases as PubMed, Scopus, and Web of Science. The present research included cross-sectional, longitudinal, and case-control studies. Study selection, data extraction, and risk of bias assessment were conducted by two researchers independently. The Newcastle-Ottawa checklist was utilized to evaluate the quality of studies. The random effects model was employed to perform a meta-analysis. Results In total, 32 studies were included in this systematic review, out of which 26 articles were eligible for meta-analysis. The results showed that 68.75% of the studies were of high quality, and there is a significant relationship between social support and elder maltreatment. Accordingly, the lack of social support increased overall maltreatment (odds ratio: 1.24, 95% confidence interval: 1.16–1.33; I2 = 92.3%, p = 0.000)). Moreover, lack of social support had an increasing effect on the level of psychological abuse (1.55, 1.18–2.04; 88.7%, p = 0.000), physical abuse (1.31, 0.42–4.11; 76.3%, p = 0.005), and neglect (2.02, 0.86–4.72; 87.9%, p = 0.000), which shows heterogeneities among the results of the included studies. On the contrary, the lack of social support showed a decreasing effect on financial abuse (0.92, 0.70–1.21; 62.1%, p = 0.022). Conclusion This systematic review provides evidence that social support in the form of structural or functional support may plays an important role in improving the quality of life of the elderly.

Aim To assess machine-learning models, their methodological quality, compare their performance, and highlight their limitations. Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations were applied. Electronic databases Science Direct, MEDLINE through (PubMed, Google Scholar), EBSCO, ERIC, and CINAHL were searched for the period of January 2016 to September 2023. Using a pre-designed data extraction sheet, the review data were extracted. Big data, risk assessment, colorectal cancer, and artificial intelligence were the main terms. Results Fifteen studies were included. A total of 3,057,329 colorectal cancer (CRC) health records, including those of adult patients older than 18, were used to generate the results. The curve's area under the curve ranged from 0.704 to 0.976. Logistic regression, random forests, and colon flag were often employed techniques. Overall, these trials provide a considerable and accurate CRC risk prediction. Conclusion An up-to-date summary of recent research on the use of big data in CRC prediction was given. Future research can be facilitated by the review's identification of gaps in the literature. Missing data, a lack of external validation, and the diversity of machine learning algorithms are the current obstacles. Despite having a sound mathematical definition, area under the curve application depends on the modelling context. [ABSTRACT FROM AUTHOR]

The quality of teaching and pedagogical practices of teachers is a global issue in education. The success of Six Sigma in several industries stimulates its potential to be applied in the field of education. However, discussions related to Six Sigma development in systematic education are still very limited. Therefore, this systematic literature study was conducted to synthesize empirical data on the implementation of the Six Sigma approach in education. This study focuses on two main objectives, namely to identify the trends in the implementation of the Six Sigma approach in education based on national and year tendencies as well as to identify research sampling trends and the focus of the field of study. The Web of Science and Scopus databases have been used based on the preferred reporting items for systematic reviews and meta-analyses (PRISMA). The findings of systematic literature articles showed that India is the most dominant country conducting Six Sigma studies in education. Furthermore, related studies were conducted the most in 2017. In addition, the research samples are also more focused on the context of higher education institutions. These findings help improve the general understanding of Six Sigma in education to improve the quality of teachers in schools further. [ABSTRACT FROM AUTHOR]

This article delves into the significance and utility of literature review articles in the field of management research, encompassing their three most prominent forms: structured literature reviews, bibliometric analyses, and meta-analyses. It discusses the evolving role of literature reviews as essential tools in a research process, their methodological intricacies, and their contribution to shaping the landscape of management studies. Through a thorough examination of their merits, limitations, and best practices, our article sheds light on how literature review articles serve as valuable resources for scholars, policymakers, and practitioners in the field of management. In addition, the article points towards opportunities for using AI tools, for example Google Colab, ChatGPT, Methods Wizards, or Petal for single or multiple stages and tasks of structured literature analyses. [ABSTRACT FROM AUTHOR]

Achene diversity of 12 genera with 22 species of the tribe Anthemideae was studied using light and scanning electron microscopy. These genera are Achillea L., Anacyclus L., Anthemis L., Brocchia Vis., Chlamydophora Ehrenb. ex Less., Cladanthus Cass., Cota G. Jay, Cotula L. Glebionis Cass., Matricaria L., Tanacetum L., and Tripleurospermum Sch.Bip. A description of the achene of each species, a key to the investigated taxa based on morphological and anatomical features, as well as drawings of cross sections, are provided, and SEM micrographs of achenes are provided. Macro‐ and micro‐morphological criteria concerned with achenes were investigated, and the taxonomic relationships between the studied taxa were discussed. [ABSTRACT FROM AUTHOR]

Renewable energies can reduce emissions from fossil fuel-based power production by a significant amount, reducing climate change. Among the several options being investigated, hydrogen is now recognized as one of the primary enabling technologies for future large-scale and long-term green storage of renewable energy. However, using clean and renewable energy sources like water and sunlight is the best option. According to recent studies, photoelectrochemical (PEC) water splitting is a potential technology for creating hydrogen using free solar energy since hydrogen and oxygen gases may be easily identified in PEC. This study uses bibliometric and systematic literature review methodologies to examine the scientific understanding of PEC water splitting and hydrogen generation, evaluating 936 articles issued in the Web of Science database from 1970 to 2022. The authors looked at how PEC water splitting research has developed compared to prior research, what criteria make up practical approaches, and what subjects have emerged as new trends in reacting to changing situations. The key findings from the article analysis, future research potential, and practical implications for the field are discussed. [Display omitted] • A bibliometric analysis of photoelectrochemical and hydrogen production is conducted. • Web of Science database from 1970 to 2022 was used in this review. • The key findings from the article analysis are discussed. • Future research potential and practical implications for the field of study are explored. [ABSTRACT FROM AUTHOR]

Simple Summary: Malignant melanoma is a highly aggressive malignancy, accounting for the majority of skin cancer deaths. Its global incidence rate has been increasing rapidly over the past few decades, and accurate disease diagnosis is crucial for optimal patient management. Imaging modalities, such as positron emission tomography (PET), play a pivotal role in accomplishing this objective. Based on current guidelines, [18F]F-FDG PET is recommended for the assessment of distant metastases in advanced-stage melanoma patients. In addition, it is indicated in patient follow-up. However, to our knowledge, there is no comprehensive investigation in the literature reporting the real-world performance of [18F]F-FDG PET in melanoma patients across a broad spectrum of clinical scenarios. Thus, we aimed to describe the performance of [18F]F-FDG PET in a wide range of detection-based clinical scenarios (e.g., initial staging, re-staging, locoregional detection, distant metastasis diagnosis) by conducting a systematic review and meta-analysis of the existing literature. We described the diagnostic performance of [18F]F-FDG-PET in malignant melanoma by conducting a comprehensive systematic review and meta-analysis of the existing literature. The study was designed following PRISMA-DTA. Original articles with adequate crude data for meta-analytic calculations that evaluated [18F]F-FDG-PET and compared it with a valid reference standard were considered eligible. The pooled measurements were calculated based on the data level (patient/lesion-based). Regarding sub-groups, diagnostic performances were calculated for local, regional and distant involvement. The bivariate model was employed to calculate sensitivity and specificity. The initial search resulted in 6678 studies. Finally, 100 entered the meta-analysis, containing 82 patient-based (10,403 patients) and 32 lesion-based (6188 lesions) datasets. At patient level, overall, [18F]F-FDG-PET had pooled sensitivity and specificity of 81% (95%CI: 73–87%) and 92% (95%CI: 90–94%), respectively. To detect regional lymph node metastasis, the pooled sensitivity and specificity were 56% (95%CI: 40–72%) and 97% (95%CI: 94–99%), respectively. To detect distant metastasis, they were 88% (95%CI: 81–93%) and 94% (95%CI: 91–96%), respectively. At lesion level, [18F]F-FDG-PET had a pooled sensitivity and specificity of 70% (95%CI: 57–80%) and 94% (95%CI: 88–97%), respectively. Thus, [18F]F-FDG-PET is a valuable diagnostic modality for melanoma assessment. It was accurate in various clinical scenarios. However, despite its high specificity, it showed low sensitivity in detecting regional lymph node metastasis and could not replace lymph node biopsy. [ABSTRACT FROM AUTHOR]

Plant‐parasitic nematodes (PPNs) are one of the most damaging pests to plants and are able to cause significant damage to all parts of plants, including stems, leaves, flowers, fruits and roots. Studies on the diversity, host range, distribution and identification methods of PPNs are therefore vital in order to create a basis for management. This current study represents the first dedicated investigation of PPNs from medicinal plants in Vietnam, focusing on the diversity of nematodes associated with 23 different plant species. In combination with a literature review of PPNs in Vietnam, this work has resulted in an updated list of 217 PPN species belonging to 40 genera, 15 families and three orders and also provides a pictorial online key for the identification of 52 most common and important PPN genera of the world. This key is based on the most crucial diagnostic features of PPN females, including female body shape, cuticle, labial shape, cephalic framework, stylet, stylet base, pharynx, median bulb, pharyngeal gland, vulva, tail shape and phasmid. Pictorial representations of these genera and their diagnostic characters are included in the browser‐based key to benefit users from all levels in nematology, be they beginners or experts. [ABSTRACT FROM AUTHOR]

This article presents a proposal for organizing literature in a visual sieve based on a conceptual matrix based on the application of the Systematic Review of Literature methodology and integration of information within the three phases of the scientific method of research to manage a state of the art or state of knowledge. [ABSTRACT FROM AUTHOR]

Background: Social anxiety disorder (SAD) is a debilitating psychiatric disorder that affects occupational and social functioning. Virtual reality (VR) therapies can provide effective treatment for people with SAD. However, with rapid innovations in immersive VR technology, more contemporary research is required to examine the effectiveness and concomitant user experience outcomes (ie, safety, usability, acceptability, and attrition) of emerging VR interventions for SAD. Objective: The aim of this systematic review was to examine the effectiveness and user experience of contemporary VR interventions among people with SAD. Methods: The Cochrane Library, Emcare, PsycINFO, PubMed, ScienceDirect, Scopus, and Web of Science databases were searched between January 1, 2012, and April 26, 2022. Deduplicated search results were screened based on title and abstract information. Full-text examination was conducted on 71 articles. Studies of all designs and comparator groups were included if they appraised the effectiveness and user experience outcomes of any immersive VR intervention among people with SAD. A standardized coding sheet was used to extract data on key participant, intervention, comparator, outcome, and study design items. Results: The findings were tabulated and discussed using a narrative synthesis. A total of 18 studies met the inclusion criteria. Conclusions: The findings showed that VR exposure therapy--based interventions can generally provide effective, safe, usable, and acceptable treatments for adults with SAD. The average attrition rate from VR treatment was low (11.36%) despite some reported user experience difficulties, including potential simulator sickness, exposure-based emotional distress, and problems with managing treatment delivered in a synchronous group setting. This review also revealed several research gaps, including a lack of VR treatment studies on children and adolescents with SAD as well as a paucity of standardized assessments of VR user experience interactions. More studies are required to address these issues. [ABSTRACT FROM AUTHOR]

Saprolegniaceae s.l. is a species-rich family of the monophyletic order Saprolegniales (Oomycota, Straminipila). Members of this family are primarily saprotrophs on cellulosic, chitinous, and proteinaceous materials in both aquatic and terrestrial ecosystems. This family also includes pathogens infecting various hosts, such as plants, crustaceans, and fishes at various life cycle stages. A diversity survey of Saprolegniaceae s.l. from freshwater and soil of the Brazilian Atlantic Rainforest resulted in 20 species isolated and identified through morphological and molecular analyses. These analyses revealed two new genera (Beakesia and Cokeria) and two new species, Achlya delicata and Brevilegnia milaneziana. Beakesia is proposed to accommodate Achlya catenulata, while Cokeria includes species with subcentric and centric oospores previously assigned to Achlya (A. racemosa, A. radiosa, and A. sparrowii). Our findings highlight the importance of additional sampling and studies in biodiversity-rich areas such as the Brazilian Atlantic Rainforest. They also provide a new perspective on the evolutionary relationships and nomenclatural delineation of traditional Oomycota genera, and revisit the family subdivisions of Saprolegniales, formally introducing Achlyaceae. [ABSTRACT FROM AUTHOR]

This study aims to determine the main factors that influence dysfunctional audit behavior. The method used in this study is the literature review (SLR) method. The survey was conducted on previous studies whose research objects were Auditors at Public Accounting Firms in Indonesia. The research data was obtained from journals in Google Scholar on the website https://google.scholar/ in 2018-2022. The main findings of this study found that the most influential factors (determinants) in dysfunctional audit behavior were dysfunctional audit behavior, namely time budget pressure, locus of control, task complexity and rotation intention, auditor performance, and personal character. Auditor performance, Machiavellian, moral competence (Akhlaq Al Karimah), Spiritual Intelligence, Stress at work, Furthermore, future research must also consider the need to explore, reflect and ask questions more critically, not from the foregone side. For example, ask again how Public Accounting Firm leaders conduct performance assessments to reduce dysfunctional auditor behavior. [ABSTRACT FROM AUTHOR]

It seems that every knowledge arises from a paradigm and is defined with its own words; words make it possible to transfer knowledge and show their epistemological point of view. In addition, specialized terms and their definitions are basic in transferring concepts and expanding science. Therefore, it seems that their imprecise application, especially in research activities, can lead to a deviation in the recognition of the researcher's intellectual paradigm, and subsequently questioning the questions and goals, theoretical and operational solutions, findings, and especially the research results. For this reason, the present study attempts to define the term "challenge" correctly and explain a framework of its criteria in urban research, especially in tourism. Then, it analyzes the content of domestic and foreign articles on sustainable tourism, and finally, it compares their approach with this term. The present qualitative research, using an interpretive-critical paradigm and employing an interrogative strategy, has collected the necessary information through library studies and utilized the systematic content analysis method. Based on the results of this research, the desired definition of the word "challenge" in tourism research is: "A challenge is a new condition and situation that introduces issues and problems into various areas and dimensions, from outside the urban system, and influences its future trajectory; depending on its scale, the urban system requires the responsible and active deployment of all its potential and actual capabilities in order to provide promising solutions to overcome prevailing conditions and achieve desired goals." Ultimately, based on a comparative analysis of forty domestic and foreign articles, it seems that currently, some domestic researchers do not have a clear and accurate understanding of the term "challenge" according to the defined criteria. It appears that one of the main reasons for the difference in attitude towards the term "challenge" in domestic and foreign research is the literal translation of this term into Persian; which should be considered in future research to take into account all aspects of the concept and its criteria. [ABSTRACT FROM AUTHOR]

Control of OHS risks in the mining industry has been attracting increasing attention in recent years. Because of their great diversity in a complex system, hazards can be difficult to identify and classify, especially when system components interact. Risk cannot be managed successfully without comprehensive investigation of all its aspects. A coherent and integrated classification for identifying and categorizing all hazards is currently lacking in mining. We propose an integrated system classification of OHS hazards in mining based on our review of 44 studies retrieved using PRISMA. Considering Canadian and international standards, regulations and conventions, new hazard categories are proposed and hazard prevention is discussed from 12 perspectives: physical, chemical, biological, ergonomic, accident and psychosocial risks, as well as policy, legislation, management, design, geography, and uncertainty, with reference to each of the four phases of a typical mine life cycle, the hazards were shown in a portrait. This paper provides suitable categories based on rational data for creating a portrait in order to OHS hazards prevention in life cycle activity in mine. [ABSTRACT FROM AUTHOR]

Introduction and aims: Many studies have investigated the relationship between social support and the prevention of elder abuse; however, their results are somehow inconsistent in terms of the association. This systematic review and meta-analysis aimed to investigate the published studies on the relationship between social support and the prevention of elder maltreatment. Materials and methods: An electronic search was conducted until January 2023, using such databases as PubMed, Scopus, and Web of Science. The present research included cross-sectional, longitudinal, and case-control studies. Study selection, data extraction, and risk of bias assessment were conducted by two researchers independently. The Newcastle-Ottawa checklist was utilized to evaluate the quality of studies. The random effects model was employed to perform a meta-analysis. Results: In total, 32 studies were included in this systematic review, out of which 26 articles were eligible for meta-analysis. The results showed that 68.75% of the studies were of high quality, and there is a significant relationship between social support and elder maltreatment. Accordingly, the lack of social support increased overall maltreatment (odds ratio: 1.24, 95% confidence interval: 1.16–1.33; I2 = 92.3%, p = 0.000)). Moreover, lack of social support had an increasing effect on the level of psychological abuse (1.55, 1.18–2.04; 88.7%, p = 0.000), physical abuse (1.31, 0.42–4.11; 76.3%, p = 0.005), and neglect (2.02, 0.86–4.72; 87.9%, p = 0.000), which shows heterogeneities among the results of the included studies. On the contrary, the lack of social support showed a decreasing effect on financial abuse (0.92, 0.70–1.21; 62.1%, p = 0.022). Conclusion: This systematic review provides evidence that social support in the form of structural or functional support may plays an important role in improving the quality of life of the elderly. [ABSTRACT FROM AUTHOR]

The main objective of this systematic review was to synthesize the evidence on the occurrence and characteristics of stuttering in individuals with Down syndrome and thus contribute knowledge about stuttering in this population. Group studies reporting outcome measures of stuttering were included. Studies with participants who were preselected based on their fluency status were excluded. We searched the Eric, PsychInfo, Medline, Scopus, and Web of Science Core Collection databases on 3rd January 2022 and conducted supplementary searches of the reference lists of previous reviews and the studies included in the current review, as well as relevant speech and language journals. The included studies were coded in terms of information concerning sample characteristics, measurement approaches, and stuttering-related outcomes. The appraisal tool for cross-sectional studies (AXIS) was used to evaluate study quality. We identified 14 eligible studies, with a total of 1,833 participants (mean = 131.29, standard deviation = 227.85, median = 45.5) between 3 and 58 years of age. The estimated occurrence of stuttering ranged from 2.38 to 56%, which is substantially higher than the estimated prevalence (1%) of stuttering in the general population. The results also showed that stuttering severity most often was judged to be mild- to-moderate and that individuals with Down syndrome displayed secondary behaviors when these were measured. However, little attention has been paid to investigating the potential adverse effects of stuttering for individuals with Down syndrome. We judged the quality of the evidence to be moderate-to-low. The negative evaluation was mostly due to sampling limitations that decreased the representability and generalizability of the results. Based on the high occurrence of stuttering and the potential negative effects of this condition, individuals with Down syndrome who show signs of stuttering should be referred to a speech and language pathologist for an evaluation of their need for stuttering treatment. [ABSTRACT FROM AUTHOR]

Purpose: The aim of the present study was to evaluate the pooled efficacy of percutaneous tibial nerve stimulation (PTNS) in patients with low anterior resection syndrome (LARS). Material and Methods: This study was based on the Cochrane Handbook for Systematic Reviews of Interventions and the PRISMA guidelines. The primary endpoint was the pooled effect size of PTNS in LARS score (LARSS). Secondary endpoints included incontinence (Fecal Incontinence Score—FIC, Obstructive Defecation Syndrome—ODS), sexual functionality and quality of life (QoL) questionnaires, and manometric evaluations. Continuous outcomes were reported as weighted mean difference (WMD), with the corresponding 95% confidence interval (95% CI). Quality evaluation was performed via the National Institutes of Health (NIH) quality assessment tool. Results: Overall, 5 studies were included. PTNS resulted to reduced LARSS values (WMD: − 5.68, 95%CI: − 7.73, − 3.63, p < 0.001). A similar effect was noted in St Mark's FIC (p < 0.001) and ODS (p = 0.02) score. An improvement in several QoL scales was found. There was no effect in sexual functionality and manometric measurements. Compared to sham, PTNS significantly improved LARSS. Conclusions: The application of PTNS in patients with LARS results in an improvement in multiple clinical parameters, including defecation functionality and quality of life. Due to several study limitations, further high quality RCTs are required to delineate the exact efficacy of PTNS. [ABSTRACT FROM AUTHOR]

Background. On 23 July 2022, the World Health Organization declared a Public Health Emergency of International Concern. Monkeypox is a zoonotic viral disease caused by the monkeypox virus that is transmitted from animals to humans or from human to human. To date, treatment for human monkeypox is mostly symptomatic, as there is no specific standard antiviral treatment. Persons with severe symptoms and signs, immunocompromised patients, children younger than 8 years, and pregnant individuals should be considered for specific antiviral treatment. Objective. This study aims to assess effectiveness of antiviral drugs in treatment of human monkeypox. Methodology. Published clinical trials and cohort studies on the role of antivirals in the management of human monkeypox that were identified through a comprehensive search of electronic databases up to April 1, 2023. The patients included were children and adults confirmed with monkeypox. The diagnosis was based on PCR or clinical symptoms. The intervention was antivirals administration in human monkeypox patients, versus supportive treatment/placebo. Outcome measured include the duration of monkeypox until recovery, need for hospitalization, and ICU admission. Results. We included four completed studies with 195 participants assessing the safety, pharmacokinetics, and efficacy of antiviral treatments for human monkeypox compared to placebo. Three studies investigated Tecovirimat (st-246), and one investigated Brincidofovir. Both drugs were safe, tolerable, and effective with no serious adverse effects. The other 5 studies were not completed and are ongoing. Conclusion. There are currently no approved antivirals for the treatment of monkeypox; some medications could be authorized for outbreak use and are now under investigation, such as Tecovirimat, Cidofovir, and Brincidofovir.

The paper presents an evaluation with the Type A and B methods for standard uncertainties of coefficients of a polynomial function of order k determined by n points obtained by measurement of input and output quantities. A method for deriving a posteriori distributions of function coefficients based on the transformation of estimator distributions without assuming any a priori distributions is presented. It was emphasized that since the correct values of the standard uncertainty of type A depend on the √ n-k-3 and not on the p √ n-k-1, therefore, with a small number of measurement points, the use of the classical approach leads to a significant underestimation of uncertainty. The relationships for direct evaluation with the type B method of uncertainties caused by uncorrected systematic additive (offset error) and multiplicative (gain error) effects in the measurements of both input and output quantities are derived. These standard uncertainties are determined on the basis of the manufacturers’ declared values of the maximum permissible errors of the measuring instruments used. A Monte Carlo experiment was carried out to verify the uncertainties of the coefficients and quadratic function, the results of which fully confirmed the results obtained analytically.

Abstract Introduction Adoptive cell therapy (ACT) is a rapidly evolving field. Patient-reported outcomes (PROs) allow patients to report the impact of treatment on their quality of life during and after treatment. The systematic review aims to characterise the breadth of PROs utilised in ACT cancer care and provide guidance for the use of PROs in this patient population in the future. Methods A systematic search was conducted (MEDLINE, PsycINFO, Embase and CINAHL) in August 2021 by two reviewers. Search terms covered the following: “adoptive cell therapy”, “patient-reported outcomes” and “cancer”. Studies were included if they used a PRO measure to report the impact of ACT. The methodological quality of PROs was assessed. Forward and backward reference searching was conducted of any relevant papers. A quality grading scale was applied based on Cochrane and Revenson criteria for classification of high-quality studies. Key data from the studies and the included PROs was extracted by two researchers and tabulated. Results One-hundred nine papers were identified; 11 papers were included. The majority of studies were single-arm trials or observational studies. Twenty-two different PROs were identified; none was ACT specific. The PROMIS-29 and EQ-5D were most commonly used. Few studies collected PRO data in the first 1–2 weeks. Four studies followed patients up for over a year, and a further four studies followed patients for approximately 3 months. Discussion None of the PROs identified have been designed specifically for ACT. Appropriateness of existing instruments should be considered. It should be considered whether it is appropriate to collect data more frequently in the acute stage and then less frequently during follow-up. It should be considered if one tool is suitable at all time points or if the tool should be adapted depending on time since treatment. More research is needed to identify the exact timings of PRO assessments, and qualitative work with patients is needed to determine the most important issues for them throughout the treatment and follow-up.

This systematic literature review examines the evidence base on the effectiveness of online programmes on the mental health and well-being of family carers of people with intellectual disabilities. Databases (ERIC, Medline, PsycINFO and CINAHL) were searched for intervention studies that considered online interventions for family carers of people with intellectual disabilities. Data were extracted using standardised data extraction tools. Bias was assessed using the Cochrane risk of bias tool for randomised trials (RoB 2). Screening, extraction and assessment of bias were completed independently by two members of the research team. Given the low number of included studies and different outcomes assessed within them, it was not possible to conduct a meta-analysis; therefore, data are presented narratively. Two studies met the criteria to be included in the review. Both studies utilised a feasibility randomised controlled trial methodology. One study found a significant decrease in parental stress, while the other found a significant increase in psychological well-being. Caution must be taken in drawing firm conclusions, given the small sample sizes and low retention rates in both studies. Online programmes seem to offer potential benefits to family carers of people with intellectual disabilities. However, further investigation is needed to examine these programmes, adopting a collaborative approach with family carers.

Abstract Background Global health will increasingly be determined by cities. Currently over half of the world’s population, over 4 billion people, live in cities. This systematic scoping review has been conducted to understand what cities are doing to improve health and healthcare for their populations. Methods We conducted a systematic search to identify literature on city-wide initiatives to improve health. The study was conducted in accordance with PRISMA and the protocol was registered with PROSPERO (CRD42020166210). Results The search identified 42,137 original citations, yielding 1,614 papers across 227 cities meeting the inclusion criteria. The results show that the majority of initiatives were targeted at non-communicable diseases. City health departments are making an increasing contribution; however the role of mayors appears to be limited. Conclusion The collective body of evidence identified in this review, built up over the last 130 years, has hitherto been poorly documented and characterised. Cities are a meta-system with population health dictated by multiple interactions and multidirectional feedback loops. Improving health in cities requires multiple actions, by multiple actors, at every level. The authors use the term ‘The Vital 5’. They are the five most important health risk factors; tobacco use; harmful alcohol use; physical-inactivity, unhealthy diet and planetary health. These ‘Vital 5’ are most concentrated in deprived areas and show the greatest increase in low and middle income countries. Every city should develop a comprehensive strategy and action plan to address these ‘Vital 5’.

Background: When performing nail surgery, clinicians must choose from a multitude of procedures and variations within each procedure. Much has been published to guide this decision making, but there are a lack of up to date robust systematic reviews to assess the totality of this evidence. Methods: Five databases (MEDLINE, Embase, CINAHL, Web of Science and CENTRAL) and two registers (Clinicaltrials.gov and ISRCTN) were searched to January 2022 for randomised trials evaluating the effects of a surgical intervention(s) for ingrown toenails. Two independent reviewers screened records, extracted data, assessed risk of bias and certainty of evidence. Data on co-primary outcomes of symptom relief and symptomatic regrowth were presented in our first paper. This paper presents data for the secondary outcomes and further discussion. Results: Of 3,928 records identified, 36 randomised trials were included in the systematic review. Healing time appears to be reduced with shorter application of phenol. A reduced healing time was also apparent was with the addition of curettage, although this may also increase the risk of post-operative bleeding and pain. Post operative bleeding was also reportedly lower in people who received local anaesthetic with epinephrine but no tourniquet. Use of phenol with nail bed excision may decrease the risk of infection. Lower pain scores were reported when using partial matrixectomy and surgical interventions with phenol. Shorter duration of pain was reported with phenolisation and wedge resection. Participant satisfaction was high overall. Conclusion: This second paper reports secondary outcomes from a robust systematic review of randomised trials on surgical treatment of ingrown toenails. Despite the large volume of clinical trials conducted on the topic, few clinical conclusions can be drawn due to the poor quality of these studies. Further high-quality clinical trials are needed to answer fundamental questions in the surgical treatment of ingrown toenails. [ABSTRACT FROM AUTHOR]

This article presents a detailed systematic review on the current developments in the machining of superalloys. Superalloys have extensive high temperature applications and research has been conducted in various machining processes. The conventional and nonconventional processing of superalloys is an emerging research area and needs attention. This systematic literature survey intends to consolidate, review, and critically highlight the machining aspects carried out in this field. Bibliometric analysis using BibExcel is conducted to capture new insights in the focused field of research. Articles published since 1991 on material processing of superalloys are listed and referenced. Article statistics on each class of publications have been highlighted. A citation analysis is also reported and the articles with the highest impact are identified. Geographical mapping reveals the role of universities and institutions in the focused research. Gephi is used to identify the key research clusters and topics. Seven prominent clusters were identified and articles in each research cluster have been elaborated. A quality versus quantity analysis of the various publications is done. Present state of art in the focused research and the future directions on the material processing of superalloys based on the review are reported. [ABSTRACT FROM AUTHOR]

Liquid biopsy research on Low-Grade gliomas (LGG) has remained less conspicuous than that on other malignant brain tumors. Reliable serum markers would be precious for diagnosis, follow- up and treatment. We propose a clinical utility score (CUS) for biomarkers in LGG that mirrors their clinical usefulness. We conducted a PRISMA review. We examined each biomarker classifying them by CUS and Level of Evidence (LOE). We identified four classes of biomarkers: (1). Circulating protein—(a) vitronectin discriminates LGG from HGG (Sn:98%, Sp:91%, CUS: 3, LOE: III), (b) CTLA-4 discriminates LGG from HGG, (cutoff: 220.43 pg/ml, Sn: 82%, Sp: 78%, CUS:3, LOE:III), (c) pre-operative TGF b1 predict astrocytoma (cutoff: 2.52 ng/ml, Sn: 94.9%, Sp: 100%, CUS:3, LOE:VI). (2). micro-RNA (miR)—(a) miR-16 discriminates between WHO IV and WHO II and III groups (AUC = 0.98, CUS:3, LOE: III), (b) miR-454-3p is higher in HGG than in LGG (p = 0.013, CUS:3, LOE: III), (c) miR-210 expression is related to WHO grades (Sn 83.2%, Sp 94.3%, CUS: 3, LOE: III). (3). Circulating DNA—(a) IDH1R132H mutation detected in plasma by combined COLD and digital PCR (Sn: 60%, Sp: 100%, CUS: 3, LOE: III). 4. Exosomes—(a) SDC1 serum levels could discriminate GBM from LGG (Sn: 71%, Sp: 91%, CUS: 2C, LOE: VI). Our investigation showed that miRs appear to have the highest clinical utility. The LOE of the studies assessed is generally low. A combined approach between different biomarkers and traditional diagnostics may be considered. We identified four main classes of biomarkers produced by LGG. We examined each biomarker, classifying them by clinical utility score (CUS) and level of evidence (LOE). Micro-RNA (miRs) appears to have the highest CUS and LOE. [ABSTRACT FROM AUTHOR]

Pollen morphology of 34 taxa belonging to genera Scabiosa and Lomelosia were investigated using a light microscope (LM) and scanning electron microscopy (SEM). Pollen grains of Scabiosa and Lomelosia taxa are tricolpate and triporate, respectively. Pollen shapes vary from oblate to prolate. The exine surface ornamentation can be divided into five types, namely echinate, echinatemicroechinate, echinate-gemmate, echinate-microechinate/gemmate and microechinate-gemmate. Pollen grain sizes were classified as very large in three species of Lomelosia and large in the rest. Statistical analyses revealed some quantitative morphological features, such as equatorial axes, L (polar view amb), and t (apocolpium) as the primary characters for separating the examined taxa. The taxa were separated from each other by clustering analysis of selected pollen characters, and the investigated species were placed within two clusters. Present findings revealed that some Scabiosa species should be transferred to Lomelosia depending on palynological characters. [ABSTRACT FROM AUTHOR]

Simple Summary: Prostate cancer (PCa) is diagnosed with tissue biopsy. The biopsy strategy may include needle cores covering the whole gland randomly and/or targeting abnormalities on imaging. This process aims to detect dangerous PCa; small cancers need not to be diagnosed. When deciding on biopsy and the biopsy strategy, an MRI scan has become an increasingly important tool. MRI can be used to decide to biopsy and to potentially use targeted biopsy cores only. A database of men suspected of PCa was used. It found that when solely relying on MRI to biopsy, 34% fewer men would undergo biopsy, but 7% of the potentially dangerous tumors would not have been detected. With targeted biopsy cores only, 75% fewer needle cores would be needed, but another 9% of potentially dangerous PCa would remain undetected. These missed lesions were usually the smaller ones. This information is helpful to balance the pros/cons of an MRI-based pathway. Background: Diagnostic pathways for prostate cancer (PCa) balance detection rates and burden. MRI impacts biopsy indication and strategy. Methods: A prospectively collected cohort database (N = 496) of men referred for elevated PSA and/or abnormal DRE was analyzed. All underwent biparametric MRI (3 Tesla scanner) and ERSPC prostate risk-calculator. Indication for biopsy was PIRADS ≥ 3 or risk-calculator ≥ 20%. Both targeted (cognitive-fusion) and systematic cores were combined. A hypothetical full-MRI-based pathway was retrospectively studied, omitting systematic biopsies in: (1) PIRADS 1–2 but risk-calculator ≥ 20%, (2) PIRADS ≥ 3, receiving targeted biopsy-cores only. Results: Significant PCa (GG ≥ 2) was detected in 120 (24%) men. Omission of systematic cores in cases with PIRADS 1–2 but risk-calculator ≥ 20%, would result in 34% less biopsy indication, not-detecting 7% significant tumors. Omission of systematic cores in PIRADS ≥ 3, only performing targeted biopsies, would result in a decrease of 75% cores per procedure, not detecting 9% significant tumors. Diagnosis of insignificant PCa dropped by 52%. PCa undetected by targeted cores only, were ipsilateral to MRI-index lesions in 67%. Conclusions: A biparametric MRI-guided PCa diagnostic pathway would have missed one out of six cases with significant PCa, but would have considerably reduced the number of biopsy procedures, cores, and insignificant PCa. Further refinement or follow-up may identify initially undetected cases. Center-specific data on the performance of the diagnostic pathway is required. [ABSTRACT FROM AUTHOR]

This contribution presents a comprehensive study of the unique and rich terrestrial Middle Triassic palynoflora recovered from the Quebrada de los Fósiles Formation, lower unit of the Puesto Viejo Group, San Rafael Depocenter, Mendoza Province, Argentina. The palynoflora was recorded at two sections of the unit (Quebrada de los Fósiles creek and Río Seco de la Quebrada creek), yielding diverse and well-preserved spores, pollen, freshwater algae, and fungal associations. Herein, 259 spore-pollen species are described and/or illustrated, from which eight are new: Baculatisporites magnus sp. nov., Carnisporites microspinous sp. nov., Leschikisporis variabilis sp. nov., Neoraistrickia stricta sp. nov., Limatulasporites rugulatus sp. nov., Aratrisporites circularis sp. nov., Protohaploxypinus bonapartei sp. nov. and P. diazii sp. nov. The following new combinations are proposed: Brevitriletes decorus comb. nov., B. pamelae comb. nov., B. sandrae comb. nov., Cuneatisporites cacheutensis comb. nov., C. salujhai comb. nov., and Pityosporites thoracatus comb. nov. A new emendation for Alisporites cymbatus is instituted, and A. libyaensis nom. nov. is a new name to replace A. plicatus. These microfloras present varied parental vegetation, containing high proportions of spores from Pleuromeiales, Equisetales, Marattiales, and Corystospermales pollen. The grains of Araucariaceae, Cupressaceae, Voltziales, Cordaitales, Gnetales, and Ginkgoales/Cycadales are recorded in smaller proportions. Zygospores of chlorophytic algae and fungi are also recorded in these assemblages. The microflora of the Quebrada de los Fósiles Formation is distinctive, quantitatively and qualitatively, from the rest of the Triassic microfloras, exhibiting the highest similarities in its composition with the associations of the La Veteada (Early Triassic, Olenekian) and Cerro de Las Cabras (Late Anisian-Early Ladinian) formations. [ABSTRACT FROM AUTHOR]

Background: Olfactory dysfunction has been reported to be involved in Parkinson's disease (PD) pathogenesis. However, gustatory dysfunction in PD has not been evaluated as in‐depth as olfactory dysfunction. We reviewed the previously published studies regarding gustatory function in PD patients and suggested the possibility that gustatory dysfunction may also be associated with PD. Methods: MEDLINE, Cochrane Library, Embase, and PubMed databases were searched for studies evaluating gustatory function in PD patients. We used the standardized mean difference and a 95% confidence interval (CI) as the effect analysis index regarding the taste strip test. The relative risk and 95% CI were used as the effect analysis index for the questionnaires and propylthiouracil (PTU)/phenylthiocarbamide (PTC) perception test. Statistical heterogeneity was assessed using forest plots, Cochran's Q, and the I2 statistic; heterogeneity was considered high when I2 was over 75%. Publication bias was assessed by funnel plots and the Egger bias test. Results: We identified 19 articles that reported the results of gustatory function tests in PD patients and healthy controls. Most of these studies used various gustatory tests, including taste strips, questionnaires, taste solutions, PTU/PTC perception tests, and electrogustometry, and reported significantly lower gustatory function in PD patients than in the controls. However, several articles reported contradictory results. Conclusions: Based on these studies, gustatory dysfunction is closely related to PD. However, the number of studies and enrolled subjects was small, and a unified gustatory function test was lacking. Therefore, further studies with larger populations and normalized gustatory function tests are needed. [ABSTRACT FROM AUTHOR]

The inflorescences of Portulacaceae have traditionally been considered capitula and their morphology and architecture have not been studied in detail. The purpose of this study was to expand the knowledge on the inflorescences within this family, comparing members of distinct lineages of Portulaca occurring in Brazil, to understand some systematic and evolutionary patterns within this group. Morphological characteristics of the inflorescences were analyzed using a light stereomicroscope, and for anatomical studies, we made transversal and longitudinal sections along the entire inflorescence, including involucral bracts, analyzing them using an optical microscope. We confirmed that observed inflorescences are determinate, composed of a first-order dichasium, with second-order helicoidal branches forming a cephalioid structure. The involucral leaves differed from adjacent bracts, which did not display a constriction at the base, as commonly observed in leaves. Thus, we conclude that the congested inflorescence of Portulaca is not a capitulum, but a cephalioid with different degrees of branch reduction within the genus. The Pilosa clade displayed the most congested cephalioid compared to members of the other analyzed clades. We present a new interpretation of the congested inflorescences in Portulaca and reinforce the need to analyze solitary inflorescences to understand the importance of these data to the systematics and evolution of Portulacaceae. [ABSTRACT FROM AUTHOR]

Due to the diverse and rich taxa, Asteraceae needs to explore from the untouched area. In this study, the pollen study was intended to assess the taxonomic value for Asteraceous taxa growing on the Sikaram Mountain Pak‐Afghan border. Both microscopic techniques (LM and SEM) play a significant role in the identification and classification of herbaceous species of Asteraceae for their taxonomic and systematic implication. Pollen was observed and measured for the 15 species of Asteraceae. For investigated taxa 15 pollen characters with size, shape, polar view, pollen type, aperture orientation, and exine sculpturing in the eurypalynous pollen. Consequently, the pollen grains are usually Tricolporate, triangular to circular in polar view, while, the shape of pollen varies from subulate, oblate, and prolate along with prolate to spheroidal whereas, sculpturing also varies from Scabrate to micro reticulate, echino‐perforate, Scabrate to echinate, echinate to granulate and echinate were observed. Similarly, among the quantitative data minimum values of polar and equatorial were 15.8 ± 0.74 μm in Filago pyramidata and 17.85 ± 0.39 μm in Heteropappus altaicus was measured respectively, while; the length of the spine with the least value of 2.45 ± 0.31 μm in Hertia intermedia and highest with 7.55 ± 0.31 μm was observed in Cirsium wallichii. The Exine thickness is a minimum of 1.70 ± 0.35 μm in Launaea nudicaulis and a maximum of 5.65 ± 3.59 μm in Cirssium vulgare. In addition, the highest pollen fertility (87%) in Centaurea iberica while the highest pollen sterility (32%) was recorded in Cirsium verutum. Furthermore, clustering via UPGMA, PCA, and PCoA analysis was performed for the separation of closely related taxa. It is concluded from this research work that palynological study has a crucial role in taxonomic, pure, and applied sciences. This study can be further authenticated and improved by a Phylogenetic study based on chloroplast DNA analysis & whole genome sequencing. Research Highlights: Pollen ultrastructure among 15 Asteraceous taxa.Micromorphological attributes measured via LM and SEM.Exine sculpture elements patterns provide accurate identification.Taxonomic keys were developed for its systematics implications. [ABSTRACT FROM AUTHOR]

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Introduction: Adoptive cell therapy (ACT) is a rapidly evolving field. Patient-reported outcomes (PROs) allow patients to report the impact of treatment on their quality of life during and after treatment. The systematic review aims to characterise the breadth of PROs utilised in ACT cancer care and provide guidance for the use of PROs in this patient population in the future. Methods: A systematic search was conducted (MEDLINE, PsycINFO, Embase and CINAHL) in August 2021 by two reviewers. Search terms covered the following: "adoptive cell therapy", "patient-reported outcomes" and "cancer". Studies were included if they used a PRO measure to report the impact of ACT. The methodological quality of PROs was assessed. Forward and backward reference searching was conducted of any relevant papers. A quality grading scale was applied based on Cochrane and Revenson criteria for classification of high-quality studies. Key data from the studies and the included PROs was extracted by two researchers and tabulated. Results: One-hundred nine papers were identified; 11 papers were included. The majority of studies were single-arm trials or observational studies. Twenty-two different PROs were identified; none was ACT specific. The PROMIS-29 and EQ-5D were most commonly used. Few studies collected PRO data in the first 1–2 weeks. Four studies followed patients up for over a year, and a further four studies followed patients for approximately 3 months. Discussion: None of the PROs identified have been designed specifically for ACT. Appropriateness of existing instruments should be considered. It should be considered whether it is appropriate to collect data more frequently in the acute stage and then less frequently during follow-up. It should be considered if one tool is suitable at all time points or if the tool should be adapted depending on time since treatment. More research is needed to identify the exact timings of PRO assessments, and qualitative work with patients is needed to determine the most important issues for them throughout the treatment and follow-up. [ABSTRACT FROM AUTHOR]

Objectives: To determine the factors that predict the failure of systematic prostate biopsy by examining the clinical, laboratory, and radiological parameters of patients for whom prostate cancer was detected by magnetic resonance imaging (MRI)-targeted biopsy but not by systematic biopsy. Methods: Patients were included in this study if they had undergone combined targeted and systematic biopsy and had cancer detected in the targeted biopsy. They were biopsy-naive patients and had lesions with a Prostate Imaging Reporting and Data System (PIRADS) score = 3 in the peripheral zone on MRI. The clinical, biochemical, and radiological findings of the groups with and without cancer detected in the systematic biopsy were compared. Results: A total of 100 patients had an index lesion in the peripheral zone and cancer detected by MRI-targeted biopsy. In 43 (43%) of the patients, no cancer was detected in the systematic biopsy, whereas it was detected in the other 57 (57%). Statistically significant differences were found between the two groups in terms of prostate volume and PSA density (p < 0.001 and p < 0.001, respectively). Moreover, the findings of univariate and multivariate logistic regression analyses indicated that prostate volume and lesion size are independent predictors of systematic biopsy failure. Conclusions: The success of systematic biopsy may be lower in patients with high prostate volume and low peripheral zone index lesion size. [ABSTRACT FROM AUTHOR]

A conflict of interest is one of the most important issues in Public Administration. This occurs at a time when the finger of corruption always points to officials, and a conflict of interest can be the underlying cause of corruption among officials. The objective of this study is to propose rather comprehensive actions to manage conflict of interest in the public sector in terms of reviewing the existing studies and sources in this field. By investigating valid databases, 106 studies were found as such. In the analyzed studies of this research, prevention, confrontation, and punishment strategies in cultural, legal, and structural approaches with 21 effective actions for handling this phenomenon are delineated. The study finds that the conflict of interest phenomenon is subject to more critical attention as neo-liberalism is spreading in the world. A person drawn into a conflict of interest presumably overlooks public interest, hence it is advisable to avoid conflict of interest situations. While most of the reviewed studies focus on disclosure of conflict of interest situations, there are other effective actions to prevent this phenomenon. Researches are expected to propose a variety of penalties for officials and staff who decide while drawn into the conflict of interest situations. [ABSTRACT FROM AUTHOR]

Background: Traditional and complementary medicine (T&CM) is highly utilised and draws on traditional knowledge (TK) as evidence, raising a need to explore how TK is currently used. Objectives: Examine criteria used to select, evaluate and apply TK in contemporary health contexts. Methods: Systematic search utilising academic databases (AMED, CINAHL, MEDLINE, EMBASE, SSCI, ProQuest Dissertations Theses Global), Trip clinical database and Google search engine. Citations and reference lists of included articles were searched. Reported use of TK in contemporary settings was mapped against a modified 'Exploration‐Preparation‐Implementation‐Sustainment' (EPIS) implementation framework. Results: From the 54 included articles, EPIS mapping found TK is primarily used in the Exploration phase of implementation (n = 54), with little reporting on Preparation (n = 16), Implementation process (n = 6) or Sustainment (n = 4) of TK implementation. Criteria used in selection, evaluation and application of TK commonly involved validation with other scientific/traditional evidence sources, or assessment of factors influencing knowledge translation. Discussion: One of the difficulties in validation of TK (as a co‐opted treatment) against other evidence sources is comparing like with like as TK often takes a holistic approach. This complicates further planning and evaluation of implementation. Conclusion: This review identifies important criteria for evaluating current and potential contemporary use of TK, identifying gaps in research and practice for finding, appraising and applying relevant TK studies for clinical care. [ABSTRACT FROM AUTHOR]