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54. Hospital readmission in systemic sclerosis associated pulmonary hypertension: Results from the PHAROS registry.

Author

Showalter, Kimberly, Pinheiro, Laura C, Jannat-Khah, Deanna, Sobol, Irina, Szymonifka, Jackie, Finik, Jackie, Steen, Virginia D, and Gordon, Jessica K

Subjects
PULMONARY hypertension treatment, REPORTING of diseases, KRUSKAL-Wallis Test, CONFIDENCE intervals, PULMONARY hypertension, HOME care services, SYSTEMIC scleroderma, PATIENT readmissions, FISHER exact test, MANN Whitney U Test, RISK assessment, SEVERITY of illness index, COMPARATIVE studies, DESCRIPTIVE statistics, OXYGEN therapy, LOGISTIC regression analysis, ODDS ratio, DISEASE complications
Abstract

Objective To identify individual-level factors associated with hospital readmission among individuals with SSc-associated pulmonary hypertension (SSc-PH). Methods Individuals enrolled in the Pulmonary Hypertension Assessment and Recognition of Outcomes in Scleroderma (PHAROS) registry contributed clinical data related to SSc-PH disease severity and hospital admissions. Readmission was defined as a subsequent hospitalization within 12 months of any hospital discharge. Characteristics were compared between individuals with and without readmissions using Fisher's exact test, Wilcoxon rank-sum test, or Kruskal–Wallis test. Logistic regression was used to estimate associations between clinical predictors and likelihood of readmission. Results Of 572 individuals with SSc-PH enrolled in PHAROS, 54% had ≥1 hospitalizations between 2005 and 2016. Among individuals ever-hospitalized, 34% had ≥1 readmission. Individuals with vs without readmissions had shorter median (IQR) time between index hospitalization date and next PHAROS visit [37 (3, 80) vs 81 (42, 136) days, P <0.001]. Index admissions related to PH or SSc (vs non-PH/SSc related) were associated with an increased odds of 12-month readmission [aOR 6.6 (95% CI 3.2, 13.6) and aOR 2.2 (95% CI 1.1, 4.5), respectively]. Readmission was less likely among home oxygen users (vs non-users) (aOR 0.44; 95% CI 0.22, 0.89). Race, age, sex, disease duration and disease subtype were not associated with readmission. Conclusion The strongest predictor for 12-month readmission was an index hospitalization reason related to PH. Home oxygen use was associated with lower odds of readmission. Future studies should determine whether testing for the need for home oxygen mediates the risk of readmission in SSc-PH. [ABSTRACT FROM AUTHOR]

Published
2022
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56. Responsiveness of PROMIS® Global Health Short Form in Outpatients with Systemic Lupus Erythematosus

Author

Kasturi, Shanthini, Szymonifka, Jackie, Berman, Jessica R., Kirou, Kyriakos A., Levine, Alana B., Sammaritano, Lisa R., and Mandl, Lisa A.

Subjects
Adult, Male, Health Status, Middle Aged, Article, Young Adult, Mental Health, Surveys and Questionnaires, Outpatients, Quality of Life, Humans, Lupus Erythematosus, Systemic, Female, Patient Reported Outcome Measures, Self Report, skin and connective tissue diseases, Aged
Abstract

To evaluate the longitudinal responsiveness (sensitivity to change) of the Patient-Reported Outcomes Measurement Information System (PROMIS) Global Health Short Form (PROMIS10) in outpatients with systemic lupus erythematosus (SLE).Outpatients with SLE who were receiving care at an academic medical center completed the PROMIS10 at 2 visits that were a minimum of 1 month apart. Responsiveness of the PROMIS10 global physical and mental health domains to Patient-Reported improvement or deterioration of health status was evaluated, as measured by standard validated instruments. Effect sizes of changes in PROMIS10 scores between visits were evaluated using Kruskal-Wallis testing.A total of 223 SLE patients enrolled and completed baseline surveys, with 186 (83.4%) completing a second set of questionnaires. The PROMIS10 demonstrated mild-to-moderate responsiveness to Patient-Reported improvement (effect size 0.29) and worsening (effect sizes -0.27 and -0.54) of health status for both global physical health and global mental health. Changes in the PROMIS10 correlated poorly with changes in physician-reported measures of disease activity.The PROMIS10 showed responsiveness over time to Patient-Reported changes in SLE health status, but not physician-assessed changes. These data suggest that the PROMIS10 can be used to efficiently measure and monitor important aspects of the SLE patient experience that are not captured by standard physician-derived metrics. Further studies are needed to evaluate the role of the PROMIS10 in optimizing longitudinal disease management in SLE and to determine its responsiveness in other chronic health conditions.

Published
2020

59. Prediction of Late Disease Recurrence and Extended Adjuvant Letrozole Benefit by the HOXB13/IL17BR Biomarker

Author

Sgroi, Dennis C., Carney, Erin, Zarrella, Elizabeth, Steffel, Lauren, Binns, Shemeica N., Finkelstein, Dianne M., Szymonifka, Jackie, Bhan, Atul K., Shepherd, Lois E., Zhang, Yi, Schnabel, Catherine A., Erlander, Mark G., Ingle, James N., Porter, Peggy, Muss, Hyman B., Pritchard, Katherine I., Tu, Dongsheng, Rimm, David L., and Goss, Paul E.

Published
2013
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65. General Assembly, Diagnosis, Laboratory Test: Proceedings of International Consensus on Orthopedic Infections

Author

Barrack, Robert, Bhimani, Samrath, Blevins, Jason L., Blevins, Kier, Demetres, Michelle, Figgie, Mark, Fillingham, Yale, Goodman, Susan, Huddleston, James, Kahlenberg, Cynthia, Lautenbach, Charles, Lin, Jianhao, Lonner, Jess, Lynch, Maureen, Malkani, Arthur, Martin, Lily, Mirza, Serene, Rahim Najjad, Muhammad Kazim, Penna, Sreeram, Richardson, Shawn, Sculco, Peter, Shahi, AliSina, Szymonifka, Jackie, and Wang, Qiaojie

Published
2019
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75. Performance of Dynamic Automated CT Annular Measurements Compared with Standard Manual Measurements for Transcatheter Aortic Valve Replacement Sizing

Author

Truong, Quynh A., primary, Legasto, Alan C., additional, Deaño, Roderick C., additional, Bachman, Daniel P., additional, Bhatt, Deep, additional, Al’Aref, Subhi J., additional, Devereux, Richard B., additional, Wong, S. Chiu, additional, Salemi, Arash, additional, and Szymonifka, Jackie, additional

Published
2019
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76. Histologic and Transcriptional Evidence of Subclinical Synovial Inflammation in Patients With Rheumatoid Arthritis in Clinical Remission

Author

Orange, Dana E., primary, Agius, Phaedra, additional, DiCarlo, Edward F., additional, Mirza, Serene Z., additional, Pannellini, Tania, additional, Szymonifka, Jackie, additional, Jiang, Caroline S., additional, Figgie, Mark P., additional, Frank, Mayu O., additional, Robinson, William H., additional, Donlin, Laura T., additional, Rozo, Cristina, additional, Gravallese, Ellen M., additional, Bykerk, Vivian P., additional, and Goodman, Susan M., additional

Published
2019
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80. Left ventricular wall thickness assessed by cardiac computed tomography and cardiac resynchronization therapy outcomes.

Author

Galand, Vincent, Ghoshhajra, Brian, Szymonifka, Jackie, Das, Saumya, Orencole, Mary, Barré, Valentin, Martins, Raphaël P, Leclercq, Christophe, Hung, Judy, Truong, Quynh A, and Singh, Jagmeet P

Subjects
HEART failure treatment, LEFT heart ventricle, RESEARCH, VENTRICULAR remodeling, RESEARCH methodology, MEDICAL cooperation, EVALUATION research, CARDIAC pacing, HEART ventricles, TREATMENT effectiveness, TOMOGRAPHY, COMPARATIVE studies, RESEARCH funding, HEART physiology, STROKE volume (Cardiac output), HEART failure
Abstract

Aims: Up to 30% of selected heart failure patients do not benefit clinically from cardiac resynchronization therapy (CRT). Left ventricular (LV) wall thickness (WT) analysed using computed tomography (CT) has rarely been evaluated in response to CRT and mitral regurgitation (MR) improvement. We examined the association of LVWT and the ability to reverse LV remodelling and MR improvement after CRT.Methods and Results: Fifty-four patients scheduled for CRT underwent pre-procedural CT. Reduced LVWT was defined as WT <6 mm and quantified as a percentage of total LV area. Endpoints were 6-month clinical and echocardiographic response to CRT [New York Heart Association (NYHA) class, LV ejection fraction (LVEF), LV end-diastolic volume (LVEDV), and LV end-systolic volume (LVESV)], MR improvement and 2-year major adverse cardiac events (MACE). Patients were divided into three groups according to the percentage of LVWT <6 mm area: ≤20%, 20-50%, and ≥50%. At 6 months, 75%, 71%, and 42% of the patients experienced NYHA improvement in the ≤20%, 20-50%, and ≥50% group, respectively. Additionally, ≤20% group presented higher LVEF, LVEDV, and LVESV positive response rate (86%, 59%, and 83%, respectively). Both 20-50% and ≥50% groups exhibited a lower LVEF, LVEDV, and LVESV positive response rate (52% and 42%; 47% and 45%; and 53% and 45%, respectively). Additionally, ≥25% of LVWT <6 mm inclusive of at least one papillary muscle insertion was the only predictor of lack of MR improvement. Lastly, ≥50% group experienced significantly lower 2-year MACE survival free probability.Conclusion: WT evaluated using CT could help to stratify the response to CRT and predict MR improvement and outcomes.Clinical Trial Registration: NCT01097733. [ABSTRACT FROM AUTHOR]

Published
2020
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82. Does Education Level Mitigate the Effect of Poverty on Total Knee Arthroplasty Outcomes?

Author

Goodman, Susan M., primary, Mandl, Lisa A., additional, Mehta, Bella, additional, Navarro-Millan, Iris, additional, Russell, Linda A., additional, Parks, Michael L., additional, Dey, Shirin A., additional, Crego, Daisy, additional, Figgie, Mark P., additional, Nguyen, Joseph T., additional, Szymonifka, Jackie, additional, Zhang, Meng, additional, and Bass, Anne R., additional

Published
2018
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83. Diagnostic Performance of Hybrid Cardiac Imaging Methods for Assessment of Obstructive Coronary Artery Disease Compared With Stand-Alone Coronary Computed Tomography Angiography

Author

Rizvi, Asim, primary, Han, Donghee, additional, Danad, Ibrahim, additional, Ó Hartaigh, Bríain, additional, Lee, Ji Hyun, additional, Gransar, Heidi, additional, Stuijfzand, Wijnand J., additional, Roudsari, Hadi Mirhedayati, additional, Park, Mahn Won, additional, Szymonifka, Jackie, additional, Chang, Hyuk-Jae, additional, Jones, Erica C., additional, Knaapen, Paul, additional, Lin, Fay Y., additional, Min, James K., additional, and Peña, Jessica M., additional

Published
2018
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84. Flares in Patients with Rheumatoid Arthritis after Total Hip and Total Knee Arthroplasty: Rates, Characteristics, and Risk Factors

Author

Goodman, Susan M., primary, Bykerk, Vivian P., additional, DiCarlo, Edward, additional, Cummings, Ryan W., additional, Donlin, Laura T., additional, Orange, Dana E., additional, Hoang, Annie, additional, Mirza, Serene, additional, McNamara, Michael, additional, Andersen, Kayte, additional, Bartlett, Susan J., additional, Szymonifka, Jackie, additional, and Figgie, Mark P., additional

Published
2018
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85. Development and Validation of a Simple-to-Use Nomogram for Predicting 5-, 10-, and 15-Year Survival in Asymptomatic Adults Undergoing Coronary Artery Calcium Scoring

Author

Ó Hartaigh, Bríain, primary, Gransar, Heidi, additional, Callister, Tracy, additional, Shaw, Leslee J., additional, Schulman-Marcus, Joshua, additional, Stuijfzand, Wijnand J., additional, Valenti, Valentina, additional, Cho, Iksung, additional, Szymonifka, Jackie, additional, Lin, Fay Y., additional, Berman, Daniel S., additional, Chang, Hyuk-Jae, additional, and Min, James K., additional

Published
2018
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87. MET-amplification (MET-amp) in relation to aggressive biology in esophagogastric cancer (EGC): An analysis of clinical outcomes of MET-amp vs non-MET-amp EGC.

Author

Hong, Theodore S., primary, Hwang, Katie L., additional, Clark, Jeffrey W., additional, Lennerz, Jochen K, additional, Shui, Amy, additional, Zheng, Hui, additional, Szymonifka, Jackie, additional, Corcoran, Ryan Bruce, additional, Heist, Rebecca Suk, additional, Russo, Andrea Lyn, additional, Parikh, Aparna Raj, additional, Borger, Darrell R., additional, Blaszkowsky, Lawrence Scott, additional, Faris, Jason Edward, additional, Murphy, Janet E., additional, Azzoli, Christopher G., additional, Mullen, John Thomas, additional, Ryan, David P., additional, Iafrate, A. John, additional, and Kwak, Eunice Lee, additional

Published
2018
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88. Belimumab for the Treatment of Early Diffuse Systemic Sclerosis

Author

Gordon, Jessica K., primary, Martyanov, Viktor, additional, Franks, Jennifer M., additional, Bernstein, Elana J., additional, Szymonifka, Jackie, additional, Magro, Cynthia, additional, Wildman, Horatio F., additional, Wood, Tammara A., additional, Whitfield, Michael L., additional, and Spiera, Robert F., additional

Published
2017
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89. The heart regulates the endocrine response to heart failure: cardiac contribution to circulating neprilysin

Author

Arrigo, Mattia, primary, Vodovar, Nicolas, additional, Nougué, Hélène, additional, Sadoune, Malha, additional, Pemberton, Chris J, additional, Ballan, Pamela, additional, Ludes, Pierre-Olivier, additional, Gendron, Nicolas, additional, Carpentier, Alain, additional, Cholley, Bernard, additional, Bizouarn, Philippe, additional, Cohen-Solal, Alain, additional, Singh, Jagmeet P, additional, Szymonifka, Jackie, additional, Latremouille, Christian, additional, Samuel, Jane-Lise, additional, Launay, Jean-Marie, additional, Pottecher, Julien, additional, Richards, A Mark, additional, Truong, Quynh A, additional, Smadja, David M, additional, and Mebazaa, Alexandre, additional

Published
2017
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92. Soluble CD146 Is a Novel Marker of Systemic Congestion in Heart Failure Patients: An Experimental Mechanistic and Transcardiac Clinical Study

Author

Arrigo, Mattia, primary, Truong, Quynh A, primary, Onat, Duygu, primary, Szymonifka, Jackie, primary, Gayat, Etienne, primary, Tolppanen, Heli, primary, Sadoune, Malha, primary, Demmer, Ryan T, primary, Wong, Ka Y, primary, Launay, Jean Marie, primary, Samuel, Jane-Lise, primary, Cohen-Solal, Alain, primary, Januzzi, James L, primary, Singh, Jagmeet P, primary, Colombo, Paolo C, primary, and Mebazaa, Alexandre, primary

Published
2017
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94. Neoadjuvant irinotecan, cisplatin, and concurrent radiation therapy with celecoxib for patients with locally advanced esophageal cancer

Author

Cleary, James M., primary, Mamon, Harvey J., additional, Szymonifka, Jackie, additional, Bueno, Raphael, additional, Choi, Noah, additional, Donahue, Dean M., additional, Fidias, Panos M., additional, Gaissert, Henning A., additional, Jaklitsch, Michael T., additional, Kulke, Matthew H., additional, Lynch, Thomas P., additional, Mentzer, Steven J., additional, Meyerhardt, Jeffrey A., additional, Swanson, Richard S., additional, Wain, John, additional, Fuchs, Charles S., additional, and Enzinger, Peter C., additional

Published
2016
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95. Clinical correlation with codon-specific mutations in metastatic colorectal cancer.

Author

Kamran, Sophia C., primary, Clark, Jeffrey W., additional, Borger, Darrell R., additional, Szymonifka, Jackie, additional, Kwak, Eunice Lee, additional, Blaszkowsky, Lawrence Scott, additional, Murphy, Janet E., additional, Goyal, Lipika, additional, Allen, Jill N., additional, Wo, Jennifer Yon-Li, additional, Zhu, Andrew X., additional, Iafrate, A. John, additional, Corcoran, Ryan Bruce, additional, Ryan, David P., additional, and Hong, Theodore S., additional

Published
2016
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97. USEFULNESS OF ATHEROSCLEROTIC PLAQUE DIFFUSENESS AND VOLUME BY CORONARY COMPUTED TOMOGRAPHY ANGIOGRAPHY FOR PREDICTING CORONARY LESION-SPECIFIC ISCHEMIA BY FRACTIONAL FLOW RESERVE

Author

Rizvi, Asim, primary, Danad, Ibrahim, additional, Szymonifka, Jackie, additional, Han, Donghee, additional, Lee, Ji Hyun, additional, Mauri, Laura, additional, Leon, Martin, additional, Lin, Fay, additional, Hartaigh, Briain O., additional, and Min, James, additional

Published
2016
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