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431 results on '"Tabori, U"'

51. Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations.

Author: Dunn S., Cain J., Brennan C., Souweidane M.M., Jones C., Allis C.D., Brudno M., Becher O., Buczkowicz P., Hoeman C., Rakopoulos P., Pajovic S., Letourneau L., Dzamba M., Morrison A., Lewis P., Bouffet E., Bartels U., Zuccaro J., Agnihotri S., Ryall S., Barszczyk M., Chornenkyy Y., Bourgey M., Bourque G., Montpetit A., Cordero F., Castelo-Branco P., Mangerel J., Tabori U., Ho K.C., Huang A., Taylor K.R., Mackay A., Bendel A.E., Nazarian J., Fangusaro J.R., Karajannis M.A., Zagzag D., Foreman N.K., Donson A., Hegert J.V., Smith A., Chan J., Lafay-Cousin L., Hawkins C., Hukin J., Dunham C., Scheinemann K., Michaud J., Zelcer S., Ramsay D., Dunn S., Cain J., Brennan C., Souweidane M.M., Jones C., Allis C.D., Brudno M., Becher O., Buczkowicz P., Hoeman C., Rakopoulos P., Pajovic S., Letourneau L., Dzamba M., Morrison A., Lewis P., Bouffet E., Bartels U., Zuccaro J., Agnihotri S., Ryall S., Barszczyk M., Chornenkyy Y., Bourgey M., Bourque G., Montpetit A., Cordero F., Castelo-Branco P., Mangerel J., Tabori U., Ho K.C., Huang A., Taylor K.R., Mackay A., Bendel A.E., Nazarian J., Fangusaro J.R., Karajannis M.A., Zagzag D., Foreman N.K., Donson A., Hegert J.V., Smith A., Chan J., Lafay-Cousin L., Hawkins C., Hukin J., Dunham C., Scheinemann K., Michaud J., Zelcer S., and Ramsay D.
Abstract: Diffuse intrinsic pontine glioma (DIPG) is a fatal brain cancer that arises in the brainstem of children, with no effective treatment and near 100% fatality. The failure of most therapies can be attributed to the delicate location of these tumors and to the selection of therapies on the basis of assumptions that DIPGs are molecularly similar to adult disease. Recent studies have unraveled the unique genetic makeup of this brain cancer, with nearly 80% found to harbor a p.Lys27Met histone H3.3 or p.Lys27Met histone H3.1 alteration. However, DIPGs are still thought of as one disease, with limited understanding of the genetic drivers of these tumors. To understand what drives DIPGs, we integrated whole-genome sequencing with methylation, expression and copy number profiling, discovering that DIPGs comprise three molecularly distinct subgroups (H3-K27M, silent and MYCN) and uncovering a new recurrent activating mutation affecting the activin receptor gene ACVR1 in 20% of DIPGs. Mutations in ACVR1 were constitutively activating, leading to SMAD phosphorylation and increased expression of the downstream activin signaling targets ID1 and ID2. Our results highlight distinct molecular subgroups and novel therapeutic targets for this incurable pediatric cancer. © 2014 Nature America, Inc. All rights reserved.
Published: 2014

52. Epigenomic alterations define lethal CIMP-positive ependymomas of infancy.

Author: Mack, S, Mack, S, Witt, H, Piro, R, Gu, L, Zuyderduyn, S, Stütz, A, Wang, X, Gallo, M, Garzia, L, Zayne, K, Zhang, X, Ramaswamy, V, Jäger, N, Jones, D, Sill, M, Pugh, T, Ryzhova, M, Wani, K, Shih, D, Head, R, Remke, M, Bailey, S, Zichner, T, Faria, C, Barszczyk, M, Stark, S, Seker-Cin, H, Hutter, S, Johann, P, Bender, S, Hovestadt, V, Tzaridis, T, Dubuc, A, Northcott, P, Peacock, J, Bertrand, K, Agnihotri, S, Cavalli, F, Clarke, I, Nethery-Brokx, K, Creasy, C, Verma, S, Koster, J, Wu, X, Yao, Y, Milde, T, Sin-Chan, P, Zuccaro, J, Lau, L, Pereira, S, Castelo-Branco, P, Hirst, M, Marra, M, Roberts, S, Fults, D, Massimi, L, Cho, Y, Van Meter, T, Grajkowska, W, Lach, B, Kulozik, A, von Deimling, A, Witt, O, Scherer, S, Fan, X, Muraszko, K, Kool, M, Pomeroy, S, Jabado, N, Rutka, J, Bouffet, E, Korbel, J, Lupien, M, Aldape, K, Bader, G, Eils, R, Lichter, P, Dirks, P, Pfister, S, Korshunov, A, Taylor, M, Huang, A, Tabori, U, Hawkins, C, Malkin, D, Kongkham, P, Gupta, Nalin, Phillips, Joanna, Weiss, William, Mack, S, Mack, S, Witt, H, Piro, R, Gu, L, Zuyderduyn, S, Stütz, A, Wang, X, Gallo, M, Garzia, L, Zayne, K, Zhang, X, Ramaswamy, V, Jäger, N, Jones, D, Sill, M, Pugh, T, Ryzhova, M, Wani, K, Shih, D, Head, R, Remke, M, Bailey, S, Zichner, T, Faria, C, Barszczyk, M, Stark, S, Seker-Cin, H, Hutter, S, Johann, P, Bender, S, Hovestadt, V, Tzaridis, T, Dubuc, A, Northcott, P, Peacock, J, Bertrand, K, Agnihotri, S, Cavalli, F, Clarke, I, Nethery-Brokx, K, Creasy, C, Verma, S, Koster, J, Wu, X, Yao, Y, Milde, T, Sin-Chan, P, Zuccaro, J, Lau, L, Pereira, S, Castelo-Branco, P, Hirst, M, Marra, M, Roberts, S, Fults, D, Massimi, L, Cho, Y, Van Meter, T, Grajkowska, W, Lach, B, Kulozik, A, von Deimling, A, Witt, O, Scherer, S, Fan, X, Muraszko, K, Kool, M, Pomeroy, S, Jabado, N, Rutka, J, Bouffet, E, Korbel, J, Lupien, M, Aldape, K, Bader, G, Eils, R, Lichter, P, Dirks, P, Pfister, S, Korshunov, A, Taylor, M, Huang, A, Tabori, U, Hawkins, C, Malkin, D, Kongkham, P, Gupta, Nalin, Phillips, Joanna, and Weiss, William
Abstract: Ependymomas are common childhood brain tumours that occur throughout the nervous system, but are most common in the paediatric hindbrain. Current standard therapy comprises surgery and radiation, but not cytotoxic chemotherapy as it does not further increase survival. Whole-genome and whole-exome sequencing of 47 hindbrain ependymomas reveals an extremely low mutation rate, and zero significant recurrent somatic single nucleotide variants. Although devoid of recurrent single nucleotide variants and focal copy number aberrations, poor-prognosis hindbrain ependymomas exhibit a CpG island methylator phenotype. Transcriptional silencing driven by CpG methylation converges exclusively on targets of the Polycomb repressive complex 2 which represses expression of differentiation genes through trimethylation of H3K27. CpG island methylator phenotype-positive hindbrain ependymomas are responsive to clinical drugs that target either DNA or H3K27 methylation both in vitro and in vivo. We conclude that epigenetic modifiers are the first rational therapeutic candidates for this deadly malignancy, which is epigenetically deregulated but genetically bland.
Published: 2014

53. Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

Author: Mack, S. C., Witt, H., Piro, R. M., Gu, L., Zuyderduyn, S., Stütz, A. M., Wang, X., Gallo, M., Garzia, L., Zayne, K., Zhang, X., Ramaswamy, V., Jäger, N., Jones, D. T. W., Sill, M., Pugh, T. J., Ryzhova, M., Wani, K. M., Shih, D. J. H., Head, R., Remke, M., Bailey, S. D., Zichner, T., Faria, C. C., Barszczyk, M., Stark, S., Seker-Cin, H., Hutter, S., Johann, P., Bender, S., Hovestadt, V., Tzaridis, T., Dubuc, A. M., Northcott, P. A., Peacock, J., Bertrand, K. C., Agnihotri, S., Cavalli, F. M. G., Clarke, I., Nethery-Brokx, K., Creasy, C. L., Verma, S. K., Koster, J., Wu, X., Yao, Y., Milde, T., Sin-Chan, P., Zuccaro, J., Lau, L., Pereira, S., Castelo-Branco, P., Hirst, M., Marra, M. A., Roberts, S. S., Fults, D., Massimi, Luca, Cho, Y. J., Van Meter, T., Grajkowska, W., Lach, B., Kulozik, A. E., Von Deimling, A., Witt, O., Scherer, S. W., Fan, X., Muraszko, K. M., Kool, M., Pomeroy, S. L., Gupta, N., Phillips, J., Huang, A., Tabori, U., Hawkins, C., Malkin, D., Kongkham, P. N., Weiss, W. A., Jabado, N., Rutka, J. T., Bouffet, E., Korbel, J. O., Lupien, M., Aldape, K. D., Bader, G. D., Eils, R., Lichter, P., Dirks, P. B., Pfister, S. M., Korshunov, A., Taylor, M. D., Massimi, L., Mack, S. C., Witt, H., Piro, R. M., Gu, L., Zuyderduyn, S., Stütz, A. M., Wang, X., Gallo, M., Garzia, L., Zayne, K., Zhang, X., Ramaswamy, V., Jäger, N., Jones, D. T. W., Sill, M., Pugh, T. J., Ryzhova, M., Wani, K. M., Shih, D. J. H., Head, R., Remke, M., Bailey, S. D., Zichner, T., Faria, C. C., Barszczyk, M., Stark, S., Seker-Cin, H., Hutter, S., Johann, P., Bender, S., Hovestadt, V., Tzaridis, T., Dubuc, A. M., Northcott, P. A., Peacock, J., Bertrand, K. C., Agnihotri, S., Cavalli, F. M. G., Clarke, I., Nethery-Brokx, K., Creasy, C. L., Verma, S. K., Koster, J., Wu, X., Yao, Y., Milde, T., Sin-Chan, P., Zuccaro, J., Lau, L., Pereira, S., Castelo-Branco, P., Hirst, M., Marra, M. A., Roberts, S. S., Fults, D., Massimi, Luca, Cho, Y. J., Van Meter, T., Grajkowska, W., Lach, B., Kulozik, A. E., Von Deimling, A., Witt, O., Scherer, S. W., Fan, X., Muraszko, K. M., Kool, M., Pomeroy, S. L., Gupta, N., Phillips, J., Huang, A., Tabori, U., Hawkins, C., Malkin, D., Kongkham, P. N., Weiss, W. A., Jabado, N., Rutka, J. T., Bouffet, E., Korbel, J. O., Lupien, M., Aldape, K. D., Bader, G. D., Eils, R., Lichter, P., Dirks, P. B., Pfister, S. M., Korshunov, A., Taylor, M. D., and Massimi, L.
Abstract: Ependymomas are common childhood brain tumours that occur throughout the nervous system, but are most common in the paediatric hindbrain. Current standard therapy comprises surgery and radiation, but not cytotoxic chemotherapy as it does not further increase survival. Whole-genome and whole-exome sequencing of 47 hindbrain ependymomas reveals an extremely low mutation rate, and zero significant recurrent somatic single nucleotide variants. Although devoid of recurrent single nucleotide variants and focal copy number aberrations, poor-prognosis hindbrain ependymomas exhibit a CpG island methylator phenotype. Transcriptional silencing driven by CpG methylation converges exclusively on targets of the Polycomb repressive complex 2 which represses expression of differentiation genes through trimethylation of H3K27. CpG island methylator phenotype-positive hindbrain ependymomas are responsive to clinical drugs that target either DNA or H3K27 methylation both in vitro and in vivo. We conclude that epigenetic modifiers are the first rational therapeutic candidates for this deadly malignancy, which is epigenetically deregulated but genetically bland. © 2014 Macmillan Publishers Limited.
Published: 2014

54. 61P - Integrated molecular signatures of TERT promoter deregulation predict disease outcomes in non-muscle invasive bladder cancer

Author: Leão, R., Lee, D., Figueiredo, A., Komosa, M., Zhang, C., Apolónio, J., Nunes, N.M., Hermanns, T., Wild, P., Poyet, C., Hamilton, R.J., Castelo-Branco, P., and Tabori, U.
Published: 2017
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55. White matter compromise predicts poor intellectual outcome in survivors of pediatric low-grade glioma

Author: Liu, F., primary, Scantlebury, N., additional, Tabori, U., additional, Bouffet, E., additional, Laughlin, S., additional, Strother, D., additional, McConnell, D., additional, Hukin, J., additional, Fryer, C., additional, Briere, M.-E., additional, Montour-Proulx, I., additional, Keene, D., additional, Wang, F., additional, and Mabbott, D. J., additional
Published: 2014
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56. PT-01 * THE IMPACT OF INITIAL RADIATION IN INFANTS AND THE RE-IRRADIATION OF RECURRENT DISEASE ON THE SURVIVAL OF EPENDYMOMA PATIENTS AT THE HOSPITAL FOR SICK CHILDREN, TORONTO

Author: Adamski, J., primary, Taylor, M., additional, Tabori, U., additional, Huang, A., additional, Bartels, U., additional, Ramaswamy, V., additional, Krishnatry, R., additional, Laperriere, N., additional, Hawkins, C., additional, and Bouffet, E., additional
Published: 2014
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57. GE-27 * THERAPEUTIC IMPLICATIONS OF MEDULLOBLASTOMA SUBGROUPS IN CHILDREN OVER AGE 3: A SINGLE CENTRE POPULATION BASED EXPERIENCE

Author: Ramaswamy, V., primary, Remke, M., additional, Adamski, J., additional, Bartels, U., additional, Tabori, U., additional, Huang, A., additional, Taylor, M., additional, and Bouffet, E., additional
Published: 2014
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58. BI-21 * BRAF MUTATION AND CDKN2A DELETIONS DEFINE A CLINICALLY DISTINCT SUBGROUP OF CHILDHOOD SECONDARY HIGH GRADE GLIOMA

Author: Mistry, M., primary, Zhukova, N., additional, Merico, D., additional, Rakopoulos, P., additional, Krishnatry, R., additional, Shago, M., additional, Stavropoulos, J., additional, Ray, P., additional, Mangerel, J., additional, Remke, M., additional, Buczkowicz, P., additional, Ramaswamy, V., additional, Rutka, J., additional, Dirks, P., additional, Taylor, M., additional, Bouffet, E., additional, Malkin, D., additional, Huang, A., additional, Hawkins, C., additional, and Tabori, U., additional
Published: 2014
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59. The impact of initial radiation in infants and the re-irradiation of recurrent disease on the survival of ependymoma patients at The Hospital for Sick Children, Toronto

Author: Adamski, J, primary, Taylor, M, additional, Tabori, U, additional, Huang, A, additional, Bartels, U, additional, Ramaswarmy, V, additional, Krishnatry, R, additional, Laperriere, N, additional, Hawkins, C, additional, and Bouffet, E, additional
Published: 2014
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60. THOR METHYLATION PROVIDES INSIGHT INTO THE TELOMERE MAINTENANCE LANDSCAPE OF MALIGNANT GLIOMAS

Author: Tabori, U., primary, Castelo-Branco, P., additional, Lee, D., additional, Gallo, M., additional, Limpan, T., additional, Mangerel, J., additional, Price, A., additional, Remke, M., additional, Zhang, C., additional, Heidari, A., additional, Wani, K., additional, Vanner, R., additional, Zadeh, G., additional, Karamchandani, J., additional, Das, S., additional, Taylor, m., additional, Hawkins, C., additional, Yan, H., additional, Aldape, K., additional, and Dirks, P. B., additional
Published: 2014
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61. NEUROPSYCHOLOGY

Author: Boman, K. K., primary, Hornquist, L., additional, Rickardsson, J., additional, Lannering, B., additional, Gustafsson, G., additional, Pitchford, N., additional, Davis, E., additional, Walker, D., additional, Hoang, D. H., additional, Pagnier, A., additional, Cousin, E., additional, Guichardet, K., additional, Schiff, I., additional, Dubois-Teklali, F., additional, Krainik, A., additional, Lazar, M. B., additional, Resnik, K., additional, Olsson, I. T., additional, Perrin, S., additional, Burtscher, I. B., additional, Lundgren, J., additional, Kahn, A., additional, Johanson, A., additional, Korzeniewska, J., additional, Dembowska-Baginska, B., additional, Perek-Polnik, M., additional, Walsh, K., additional, Gioia, A., additional, Wells, E., additional, Packer, R., additional, de Speville, E. D., additional, Dufour, C., additional, Bolle, S., additional, Giraudat, K., additional, Longaud, A., additional, Kieffer, V., additional, Grill, J., additional, Puget, S., additional, Valteau-Couanet, D., additional, Hetz-Pannier, L., additional, Noulhiane, M., additional, Chieffo, D., additional, Tamburrini, G., additional, Caldarelli, M., additional, Di Rocco, C., additional, Margelisch, K., additional, Studer, M., additional, Steinlin, M., additional, Leibundgut, K., additional, Heinks, T., additional, Longaud-Vales, A., additional, Chevignard, M., additional, Pujet, S., additional, Sainte-Rose, C., additional, Dellatolas, G., additional, Kahalley, L., additional, Grosshans, D., additional, Paulino, A., additional, Ris, M. D., additional, Chintagumpala, M., additional, Okcu, F., additional, Moore, B., additional, Stancel, H., additional, Minard, C., additional, Guffey, D., additional, Mahajan, A., additional, Herrington, B., additional, Raiker, J., additional, Manning, E., additional, Criddle, J., additional, Karlson, C., additional, Guerry, W., additional, Finlay, J., additional, Sands, S., additional, Dockstader, C., additional, Skocic, J., additional, Bouffet, E., additional, Laughlin, S., additional, Tabori, U., additional, Mabbott, D., additional, Moxon-Emre, I., additional, Scantlebury, N., additional, Taylor, M. D., additional, Malkin, D., additional, Law, N., additional, Kumabe, T., additional, Leonard, J., additional, Rubin, J., additional, Jung, S., additional, Kim, S.-K., additional, Gupta, N., additional, Weiss, W., additional, Faria, C., additional, Vibhakar, R., additional, Spiegler, B., additional, Janzen, L., additional, Liu, F., additional, Decker, L., additional, Lemiere, J., additional, Vercruysse, T., additional, Haers, M., additional, Vandenabeele, K., additional, Geuens, S., additional, Jacobs, S., additional, Van Gool, S., additional, Riggs, L., additional, Piscione, J., additional, Timmons, B., additional, Cunningham, T., additional, Bartels, U., additional, Chakravarty, M., additional, Laperriere, N., additional, Pipitone, J., additional, Strother, D., additional, Hukin, J., additional, Fryer, C., additional, McConnell, D., additional, Secco, D. E., additional, Cappelletti, S., additional, Gentile, S., additional, Cacchione, A., additional, Del Bufalo, F., additional, Staccioli, S., additional, Spagnoli, A., additional, Messina, R., additional, Carai, A., additional, Marras, C. E., additional, Mastronuzzi, A., additional, Brinkman, T., additional, Armstrong, G., additional, Kimberg, C., additional, Gajjar, A., additional, Srivastava, D. K., additional, Robison, L., additional, Hudson, M., additional, Krull, K., additional, Hardy, K., additional, Hostetter, S., additional, Hwang, E., additional, Leiss, U., additional, Bemmer, A., additional, Pletschko, T., additional, Grafeneder, J., additional, Schwarzinger, A., additional, Deimann, P., additional, Slavc, I., additional, Batchelder, P., additional, Wilkening, G., additional, Hankinson, T., additional, Foreman, N., additional, and Handler, M., additional
Published: 2014
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62. EPENDYMOMA

Author: Hoffman, L. M., primary, Donson, A. M., additional, Nakachi, I., additional, Griesinger, A. M., additional, Birks, D. K., additional, Amani, V., additional, Hemenway, M. S., additional, Liu, A. K., additional, Wang, M., additional, Hankinson, T. C., additional, Handler, M. H., additional, Foreman, N. K., additional, Zakrzewska, M., additional, Zakrzewski, K., additional, Fendler, W., additional, Stefanczyk, L., additional, Liberski, P. P., additional, Massimino, M., additional, Gandola, L., additional, Ferroli, P., additional, Valentini, L., additional, Biassoni, V., additional, Garre, M. L., additional, Sardi, I., additional, Genitori, L., additional, Giussani, C., additional, Massimi, L., additional, Bertin, D., additional, Mussano, A., additional, Viscardi, E., additional, Modena, P., additional, Mastronuzzi, A., additional, Barra, S., additional, Scarzello, G., additional, Cinalli, G., additional, Peretta, P., additional, Giangaspero, F., additional, Boschetti, L., additional, Schiavello, E., additional, Calareso, G., additional, Antonelli, M., additional, Pecori, E., additional, Di Meco, F., additional, Migliorati, R., additional, Taborelli, A., additional, Witt, H., additional, Sill, M., additional, Wani, K., additional, Mack, S. C., additional, Capper, D., additional, Pajtler, K., additional, Lambert, S., additional, Tzaridis, T., additional, Milde, T., additional, Northcott, P. A., additional, Kulozik, A. E., additional, Witt, O., additional, Collins, V. P., additional, Ellison, D. W., additional, Taylor, M. D., additional, Kool, M., additional, Jones, D. T. W., additional, Korshunov, A., additional, Ken, A., additional, Pfister, S. M., additional, Makino, K., additional, Nakamura, H., additional, Kuroda, J.-i., additional, Kuratsu, J.-i., additional, Toledano, H., additional, Margolin, Y., additional, Ohali, A., additional, Michowiz, S., additional, Johann, P., additional, Tabori, U., additional, Walker, E., additional, Hawkins, C., additional, Taylor, M., additional, Yaniv, I., additional, Avigad, S., additional, Hoffman, L., additional, Plimpton, S. R., additional, Stence, N. V., additional, Vibhakar, R., additional, Lourdusamy, A., additional, Rahman, R., additional, Ward, J., additional, Rogers, H., additional, Grundy, R., additional, Punchihewa, C., additional, Lee, R., additional, Lin, T., additional, Orisme, W., additional, Dalton, J., additional, Aronica, E., additional, Smith, A., additional, Gajjar, A., additional, Onar, A., additional, Pounds, S., additional, Tatevossian, R., additional, Merchant, T., additional, Ellison, D., additional, Parker, M., additional, Mohankumar, K., additional, Weinlich, R., additional, Phoenix, T., additional, Thiruvenkatam, R., additional, White, E., additional, Gupta, K., additional, Boop, F., additional, Ding, L., additional, Mardis, E., additional, Wilson, R., additional, Downing, J., additional, Gilbertson, R., additional, Speed, D., additional, Gould, T., additional, Consortium, t. I. E., additional, Hoffman, L. M., additional, Griesinger, A., additional, Donson, A., additional, Birks, D., additional, Ohe, N., additional, Yano, H., additional, Nakayama, N., additional, Iwama, T., additional, Wright, K., additional, Hassall, T., additional, Bowers, D. C., additional, Crawford, J., additional, Bendel, A., additional, Fisher, P. G., additional, Klimo, P., additional, Armstrong, G., additional, Qaddoumi, I., additional, Robinson, G., additional, Wetmore, C., additional, Broniscer, A., additional, Chapman, R., additional, Mayne, C., additional, Duane, H., additional, Kilday, J.-P., additional, Coyle, B., additional, Graul-Conroy, A., additional, Hartsell, W., additional, Bragg, T., additional, Goldman, S., additional, Rebsamen, S., additional, Puccetti, D., additional, Salamat, S., additional, Patel, N. J., additional, Gomi, A., additional, Oguma, H., additional, Hayase, T., additional, Kawahara, Y., additional, Yagi, M., additional, Morimoto, A., additional, Wilbur, C., additional, Dunham, C., additional, Mabbott, D., additional, Carret, A.-S., additional, Lafay-Cousin, L., additional, McNeely, P. D., additional, Eisenstat, D., additional, Wilson, B., additional, Johnston, D., additional, Hukin, J., additional, Mynarek, M., additional, Kortmann, R. D., additional, Kaatsch, P., additional, Pietsch, T., additional, Timmermann, B., additional, Fleischhack, G., additional, Benesch, M., additional, Friedrich, C., additional, von Bueren, A. O., additional, Gerber, N. U., additional, Muller, K., additional, Tippelt, S., additional, Warmuth-Metz, M., additional, Rutkowski, S., additional, von Hoff, K., additional, Murugesan, M. K., additional, Poppleton, H., additional, Currle, S., additional, Kranenburg, T., additional, Eden, C., additional, Boulos, N., additional, Dapper, J., additional, Patel, Y., additional, Freeman, B., additional, Shelat, A., additional, Stewart, C., additional, Guy, R., additional, Adamski, J., additional, Huang, A., additional, Bartels, U., additional, Ramaswamy, V., additional, Krishnatry, R., additional, Laperriere, N., additional, Bouffet, E., additional, Araki, A., additional, Chocholous, M., additional, Gojo, J., additional, Dorfer, C., additional, Czech, T., additional, Dieckmann, K., additional, Slavc, I., additional, Haberler, C., additional, Doerner, E., additional, Muehlen, A. z., additional, Kortmann, R., additional, von Buehren, A., additional, Ottensmeier, H., additional, Resch, A., additional, Kwiecien, R., additional, Faldum, A., additional, Kuehl, J., additional, Sabnis, D., additional, Storer, L., additional, Simmonds, L., additional, Blackburn, S., additional, Lowe, J., additional, Kerr, I., additional, Wohlers, I., additional, Goschzik, T., additional, Dreschmann, V., additional, Denkhaus, D., additional, Rahmann, S., additional, Klein-Hitpass, L., additional, Iglesias, M. J. L., additional, Riet, F. G., additional, Dhermain, F. D., additional, Canale, S., additional, Dufour, C., additional, Rose, C. S., additional, Puget, S., additional, Grill, J., additional, Bolle, S., additional, Parkes, J., additional, Davidson, A., additional, Figaji, A., additional, Pillay, K., additional, Kilborn, T., additional, Padayachy, L., additional, Hendricks, M., additional, Van Eyssen, A., additional, Piccinin, E., additional, Lorenzetto, E., additional, Brenca, M., additional, Aldape, K., additional, Cho, Y.-J., additional, Weiss, W., additional, Phillips, J., additional, Jabado, N., additional, Mora, J., additional, Fan, X., additional, Jung, S., additional, Lee, J. Y., additional, Zitterbart, K., additional, French, P., additional, Kros, J. M., additional, Hauser, P., additional, Faria, C., additional, and Pfister, S., additional
Published: 2014
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63. RADIOLOGY

Author: Kelly, T., primary, Prah, M., additional, Jogal, S., additional, Maheshwari, M., additional, Lew, S., additional, Schmainda, K., additional, Kannan, G., additional, Khatua, S., additional, Zaky, W., additional, Ketonen, L., additional, Drogosiewicz, M., additional, Dembowska-Baginska, B., additional, Jurkiewicz, E., additional, Nowak, K., additional, Perek, D., additional, Hirpara, D., additional, Bhatt, M., additional, Scheinemann, K., additional, Shimizu, Y., additional, Kondo, A., additional, Miyajima, M., additional, Arai, H., additional, Dvir, R., additional, Shiran, S., additional, Sira, L. B.-, additional, Roth, J., additional, Tabori, U., additional, Bouffet, E., additional, Durno, C., additional, Aronson, M., additional, Constantini, S., additional, Elhasid, R., additional, Fangusaro, J., additional, Marsh, J., additional, Bregman, C., additional, Diaz, A., additional, Byrne, R., additional, Ziel, E., additional, Goldman, S., additional, Calmon, R., additional, Grevent, D., additional, Blauwblomme, T., additional, Puget, S., additional, Sainte-Rose, C., additional, Varlet, P., additional, Dufour, C., additional, Grill, J., additional, Saitovich, A., additional, Zilbovicius, M., additional, Brunelle, F., additional, Boddaert, N., additional, Wei, L., additional, Tan, A. M., additional, Tang, P. H., additional, Orphanidou-Vlachou, E., additional, Vlachos, N., additional, Davies, N., additional, Arvanitis, T., additional, Grundy, R., additional, Peet, A., additional, Withey, S., additional, Novak, J., additional, MacPherson, L., additional, Avula, S., additional, Kumar, R., additional, Pizer, B., additional, Pettorini, B., additional, Garlick, D., additional, Mallucci, C., additional, Reddick, W., additional, Guo, J., additional, Glass, J., additional, Pryweller, J., additional, Gajjar, A., additional, Thust, S., additional, Blanco, E., additional, Mankad, K., additional, and Michalski, A., additional
Published: 2014
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64. MEDULLOBLASTOMA

Author: Vaidyanathan, G., primary, Gururangan, S., additional, Bigner, D., additional, Zalutsky, M., additional, Morfouace, M., additional, Shelat, A., additional, Megan, J., additional, Freeman, B. B., additional, Robinson, S., additional, Throm, S., additional, Olson, J. M., additional, Li, X.-N., additional, Guy, K. R., additional, Robinson, G., additional, Stewart, C., additional, Gajjar, A., additional, Roussel, M., additional, Sirachainan, N., additional, Pakakasama, S., additional, Anurathapan, U., additional, Hansasuta, A., additional, Dhanachai, M., additional, Khongkhatithum, C., additional, Hongeng, S., additional, Feroze, A., additional, Lee, K.-S., additional, Gholamin, S., additional, Wu, Z., additional, Lu, B., additional, Mitra, S., additional, Cheshier, S., additional, Northcott, P., additional, Lee, C., additional, Zichner, T., additional, Lichter, P., additional, Korbel, J., additional, Wechsler-Reya, R., additional, Pfister, S., additional, Project, I. P. T., additional, Li, K. K.-W., additional, Xia, T., additional, Ma, F. M. T., additional, Zhang, R., additional, Zhou, L., additional, Lau, K.-M., additional, Ng, H.-K., additional, Lafay-Cousin, L., additional, Chi, S., additional, Madden, J., additional, Smith, A., additional, Wells, E., additional, Owens, E., additional, Strother, D., additional, Foreman, N., additional, Packer, R., additional, Bouffet, E., additional, Wataya, T., additional, Peacock, J., additional, Taylor, M. D., additional, Ivanov, D., additional, Garnett, M., additional, Parker, T., additional, Alexander, C., additional, Meijer, L., additional, Grundy, R., additional, Gellert, P., additional, Ashford, M., additional, Walker, D., additional, Brent, J., additional, Cader, F. Z., additional, Ford, D., additional, Kay, A., additional, Walsh, R., additional, Solanki, G., additional, Peet, A., additional, English, M., additional, Shalaby, T., additional, Fiaschetti, G., additional, Baulande, S., additional, Gerber, N., additional, Baumgartner, M., additional, Grotzer, M., additional, Hayase, T., additional, Kawahara, Y., additional, Yagi, M., additional, Minami, T., additional, Kanai, N., additional, Yamaguchi, T., additional, Gomi, A., additional, Morimoto, A., additional, Hill, R., additional, Kuijper, S., additional, Lindsey, J., additional, Schwalbe, E., additional, Barker, K., additional, Boult, J., additional, Williamson, D., additional, Ahmad, Z., additional, Hallsworth, A., additional, Ryan, S., additional, Poon, E., additional, Ruddle, R., additional, Raynaud, F., additional, Howell, L., additional, Kwok, C., additional, Joshi, A., additional, Nicholson, S. L., additional, Crosier, S., additional, Wharton, S., additional, Robson, K., additional, Michalski, A., additional, Hargrave, D., additional, Jacques, T., additional, Pizer, B., additional, Bailey, S., additional, Swartling, F., additional, Petrie, K., additional, Weiss, W., additional, Chesler, L., additional, Clifford, S., additional, Kitanovski, L., additional, Prelog, T., additional, Kotnik, B. F., additional, Debeljak, M., additional, Grotzer, M. A., additional, Gevorgian, A., additional, Morozova, E., additional, Kazantsev, I., additional, Iukhta, T., additional, Safonova, S., additional, Kumirova, E., additional, Punanov, Y., additional, Afanasyev, B., additional, Zheludkova, O., additional, Grajkowska, W., additional, Pronicki, M., additional, Cukrowska, B., additional, Dembowska-Baginska, B., additional, Lastowska, M., additional, Murase, A., additional, Nobusawa, S., additional, Gemma, Y., additional, Yamazaki, F., additional, Masuzawa, A., additional, Uno, T., additional, Osumi, T., additional, Shioda, Y., additional, Kiyotani, C., additional, Mori, T., additional, Matsumoto, K., additional, Ogiwara, H., additional, Morota, N., additional, Hirato, J., additional, Nakazawa, A., additional, Terashima, K., additional, Fay-McClymont, T., additional, Walsh, K., additional, Mabbott, D., additional, Sturm, D., additional, Northcott, P. A., additional, Jones, D. T. W., additional, Korshunov, A., additional, Pfister, S. M., additional, Kool, M., additional, Hooper, C., additional, Hawes, S., additional, Kees, U., additional, Gottardo, N., additional, Dallas, P., additional, Siegfried, A., additional, Bertozzi, A. I., additional, Sevely, A., additional, Loukh, N., additional, Munzer, C., additional, Miquel, C., additional, Bourdeaut, F., additional, Pietsch, T., additional, Dufour, C., additional, Delisle, M. B., additional, Kawauchi, D., additional, Rehg, J., additional, Finkelstein, D., additional, Zindy, F., additional, Phoenix, T., additional, Gilbertson, R., additional, Trubicka, J., additional, Borucka-Mankiewicz, M., additional, Ciara, E., additional, Chrzanowska, K., additional, Perek-Polnik, M., additional, Abramczuk-Piekutowska, D., additional, Jurkiewicz, D., additional, Luczak, S., additional, Kowalski, P., additional, Krajewska-Walasek, M., additional, Sheila, C., additional, Lee, S., additional, Foster, C., additional, Manoranjan, B., additional, Pambit, M., additional, Berns, R., additional, Fotovati, A., additional, Venugopal, C., additional, O'Halloran, K., additional, Narendran, A., additional, Hawkins, C., additional, Ramaswamy, V., additional, Taylor, M., additional, Singhal, A., additional, Hukin, J., additional, Rassekh, R., additional, Yip, S., additional, Singh, S., additional, Duhman, C., additional, Dunn, S., additional, Chen, T., additional, Rush, S., additional, Fuji, H., additional, Ishida, Y., additional, Onoe, T., additional, Kanda, T., additional, Kase, Y., additional, Yamashita, H., additional, Murayama, S., additional, Nakasu, Y., additional, Kurimoto, T., additional, Kondo, A., additional, Sakaguchi, S., additional, Fujimura, J., additional, Saito, M., additional, Arakawa, T., additional, Arai, H., additional, Shimizu, T., additional, Jurkiewicz, E., additional, Daszkiewicz, P., additional, Drogosiewicz, M., additional, Hovestadt, V., additional, Buchhalter, I., additional, Jager, N. N., additional, Stuetz, A., additional, Johann, P., additional, Schmidt, C., additional, Ryzhova, M., additional, Landgraf, P., additional, Hasselblatt, M., additional, Schuller, U., additional, Yaspo, M.-L., additional, von Deimling, A., additional, Eils, R., additional, Modi, A., additional, Patel, M., additional, Berk, M., additional, Wang, L.-x., additional, Plautz, G., additional, Camara-Costa, H., additional, Resch, A., additional, Lalande, C., additional, Kieffer, V., additional, Poggi, G., additional, Kennedy, C., additional, Bull, K., additional, Calaminus, G., additional, Grill, J., additional, Doz, F., additional, Rutkowski, S., additional, Massimino, M., additional, Kortmann, R.-D., additional, Lannering, B., additional, Dellatolas, G., additional, Chevignard, M., additional, Solecki, D., additional, McKinnon, P., additional, Olson, J., additional, Hayden, J., additional, Ellison, D., additional, Buss, M., additional, Remke, M., additional, Lee, J., additional, Caspary, T., additional, Castellino, R., additional, Sabel, M., additional, Gustafsson, G., additional, Fleischhack, G., additional, Benesch, M., additional, Navajas, A., additional, Reddingius, R., additional, Delisle, M.-B., additional, Lafon, D., additional, Sevenet, N., additional, Pierron, G., additional, Delattre, O., additional, Ecker, J., additional, Oehme, I., additional, Mazitschek, R., additional, Lodrini, M., additional, Deubzer, H. E., additional, Kulozik, A. E., additional, Witt, O., additional, Milde, T., additional, Patmore, D., additional, Boulos, N., additional, Wright, K., additional, Boop, S., additional, Janicki, T., additional, Burzynski, S., additional, Burzynski, G., additional, Marszalek, A., additional, Triscott, J., additional, Green, M., additional, Rassekh, S. R., additional, Toyota, B., additional, Dunham, C., additional, Dunn, S. E., additional, Liu, K.-W., additional, Pei, Y., additional, Genovesi, L., additional, Ji, P., additional, Davis, M., additional, Ng, C. G., additional, Cho, Y.-J., additional, Jenkins, N., additional, Copeland, N., additional, Wainwright, B., additional, Tang, Y., additional, Schubert, S., additional, Nguyen, B., additional, Masoud, S., additional, Lee, A., additional, Willardson, M., additional, Bandopadhayay, P., additional, Bergthold, G., additional, Atwood, S., additional, Whitson, R., additional, Qi, J., additional, Beroukhim, R., additional, Tang, J., additional, Oro, A., additional, Link, B., additional, Bradner, J., additional, Vallero, S. G., additional, Bertin, D., additional, Basso, M. E., additional, Milanaccio, C., additional, Peretta, P., additional, Cama, A., additional, Mussano, A., additional, Barra, S., additional, Morana, G., additional, Morra, I., additional, Nozza, P., additional, Fagioli, F., additional, Garre, M. L., additional, Darabi, A., additional, Sanden, E., additional, Visse, E., additional, Stahl, N., additional, Siesjo, P., additional, Vaka, D., additional, Vasquez, F., additional, Weir, B., additional, Cowley, G., additional, Keller, C., additional, Hahn, W., additional, Gibbs, I. C., additional, Partap, S., additional, Yeom, K., additional, Martinez, M., additional, Vogel, H., additional, Donaldson, S. S., additional, Fisher, P., additional, Perreault, S., additional, Guerrini-Rousseau, L., additional, Pujet, S., additional, Kieffer-Renaux, V., additional, Raquin, M. A., additional, Varlet, P., additional, Longaud, A., additional, Sainte-Rose, C., additional, Valteau-Couanet, D., additional, Staal, J., additional, Lau, L. S., additional, Zhang, H., additional, Ingram, W. J., additional, Cho, Y. J., additional, Hathout, Y., additional, Brown, K., additional, Rood, B. R., additional, Handler, M., additional, Hankinson, T., additional, Kleinschmidt-Demasters, B. K., additional, Hutter, S., additional, Jones, D. T., additional, Kagawa, N., additional, Hirayama, R., additional, Kijima, N., additional, Chiba, Y., additional, Kinoshita, M., additional, Takano, K., additional, Eino, D., additional, Fukuya, S., additional, Yamamoto, F., additional, Nakanishi, K., additional, Hashimoto, N., additional, Hashii, Y., additional, Hara, J., additional, Yoshimine, T., additional, Wang, J., additional, Guo, C., additional, Yang, Q., additional, Chen, Z., additional, Filipek, I., additional, Swieszkowska, E., additional, Tarasinska, M., additional, Perek, D., additional, Kebudi, R., additional, Koc, B., additional, Gorgun, O., additional, Agaoglu, F. Y., additional, Wolff, J., additional, Darendeliler, E., additional, Kerl, K., additional, Gronych, J., additional, McGlade, J., additional, Endersby, R., additional, Hii, H., additional, Johns, T., additional, Sastry, J., additional, Murphy, D., additional, Ronghe, M., additional, Cunningham, C., additional, Cowie, F., additional, Jones, R., additional, Calisto, A., additional, Sangra, M., additional, Mathieson, C., additional, Brown, J., additional, Phuakpet, K., additional, Larouche, V., additional, Bartels, U., additional, Ishida, T., additional, Hasegawa, D., additional, Miyata, K., additional, Ochi, S., additional, Saito, A., additional, Kozaki, A., additional, Yanai, T., additional, Kawasaki, K., additional, Yamamoto, K., additional, Kawamura, A., additional, Nagashima, T., additional, Akasaka, Y., additional, Soejima, T., additional, Yoshida, M., additional, Kosaka, Y., additional, von Bueren, A., additional, Goschzik, T., additional, Kortmann, R., additional, von Hoff, K., additional, Friedrich, C., additional, Muehlen, A. z., additional, Warmuth-Metz, M., additional, Soerensen, N., additional, Deinlein, F., additional, Zwiener, I., additional, Faldum, A., additional, Kuehl, J., additional, KRAMER, K., additional, -Taskar, N. P., additional, Zanzonico, P., additional, Humm, J. L., additional, Wolden, S. L., additional, Cheung, N.-K. V., additional, Venkataraman, S., additional, Alimova, I., additional, Harris, P., additional, Birks, D., additional, Balakrishnan, I., additional, Griesinger, A., additional, Foreman, N. K., additional, Vibhakar, R., additional, Margol, A., additional, Robison, N., additional, Gnanachandran, J., additional, Hung, L., additional, Kennedy, R., additional, Vali, M., additional, Dhall, G., additional, Finlay, J., additional, Erdrich-Epstein, A., additional, Krieger, M., additional, Drissi, R., additional, Fouladi, M., additional, Gilles, F., additional, Judkins, A., additional, Sposto, R., additional, Asgharzadeh, S., additional, Peyrl, A., additional, Chocholous, M., additional, Holm, S., additional, Grillner, P., additional, Blomgren, K., additional, Azizi, A., additional, Czech, T., additional, Gustafsson, B., additional, Dieckmann, K., additional, Leiss, U., additional, Slavc, I., additional, Babelyan, S., additional, Dolgopolov, I., additional, Pimenov, R., additional, Mentkevich, G., additional, Gorelishev, S., additional, Laskov, M., additional, von Bueren, A. O., additional, Nowak, J., additional, Kortmann, R. D., additional, Mynarek, M., additional, Muller, K., additional, Gerber, N. U., additional, Ottensmeier, H., additional, Kwiecien, R., additional, Yankelevich, M., additional, Boyarshinov, V., additional, Glekov, I., additional, Ozerov, S., additional, Gorelyshev, S., additional, Popa, A., additional, Subbotina, N., additional, Martin, A. M., additional, Nirschl, C., additional, Polanczyk, M., additional, Bell, R., additional, Martinez, D., additional, Sullivan, L. M., additional, Santi, M., additional, Burger, P. C., additional, Taube, J. M., additional, Drake, C. G., additional, Pardoll, D. M., additional, Lim, M., additional, Li, L., additional, Wang, W.-G., additional, Pu, J.-X., additional, Sun, H.-D., additional, Ruggieri, R., additional, Symons, M. H., additional, Vanan, M. I., additional, Bolin, S., additional, Schumacher, S., additional, Zeid, R., additional, Yu, F., additional, Vue, N., additional, Gibson, W., additional, Paolella, B., additional, Swartling, F. J., additional, Kieran, M. W., additional, Bradner, J. E., additional, Maher, O., additional, Khatua, S., additional, Tarek, N., additional, Zaky, W., additional, Gupta, T., additional, Mohanty, S., additional, Kannan, S., additional, Jalali, R., additional, Kapitza, E., additional, Denkhaus, D., additional, Muhlen, A. z., additional, van Vuurden, D. G., additional, Garami, M., additional, Fangusaro, J., additional, Davidson, T. B., additional, da Costa, M. J. G., additional, Sterba, J., additional, Clifford, S. C., additional, Finlay, J. L., additional, Schmidt, R., additional, Felsberg, J., additional, Skladny, H., additional, Cremer, F., additional, Reifenberger, G., additional, Kunder, R., additional, Sridhar, E., additional, Moiyadi, A. A., additional, Goel, A., additional, Goel, N., additional, Shirsat, N., additional, Othman, R., additional, Storer, L., additional, Kerr, I., additional, Coyle, B., additional, Law, N., additional, Smith, M. L., additional, Greenberg, M., additional, Laughlin, S., additional, Malkin, D., additional, Liu, F., additional, Moxon-Emre, I., additional, Scantlebury, N., additional, Nasir, A., additional, Onion, D., additional, Lourdusamy, A., additional, Grabowska, A., additional, Cai, Y., additional, Bradshaw, T., additional, de Medeiros, R. S. S., additional, Beaugrand, A., additional, Soares, S., additional, Epelman, S., additional, Wang, W., additional, Sultan, M., additional, Wechsler-Reya, R. J., additional, Zapatka, M., additional, Radlwimmer, B., additional, Alderete, D., additional, Baroni, L., additional, Lubinieki, F., additional, Auad, F., additional, Gonzalez, M. L., additional, Puya, W., additional, Pacheco, P., additional, Aurtenetxe, O., additional, Gaffar, A., additional, Gros, L., additional, Cruz, O., additional, Calvo, C., additional, Shinojima, N., additional, Nakamura, H., additional, Kuratsu, J.-i., additional, Hanaford, A., additional, Eberhart, C., additional, Archer, T., additional, Tamayo, P., additional, Pomeroy, S., additional, Raabe, E., additional, De Braganca, K., additional, Gilheeney, S., additional, Khakoo, Y., additional, Kramer, K., additional, Wolden, S., additional, Dunkel, I., additional, Lulla, R. R., additional, Laskowski, J., additional, Goldman, S., additional, Gopalakrishnan, V., additional, Shih, D., additional, Wang, X., additional, Faria, C., additional, Raybaud, C., additional, Tabori, U., additional, Rutka, J., additional, Jacobs, S., additional, De Vathaire, F., additional, Diallo, I., additional, Llanas, D., additional, Verez, C., additional, Diop, F., additional, Kahlouche, A., additional, Puget, S., additional, Thompson, E., additional, Prince, E., additional, Amani, V., additional, Sin-Chan, P., additional, Lu, M., additional, Kleinman, C., additional, Spence, T., additional, Picard, D., additional, Ho, K. C., additional, Chan, J., additional, Majewski, J., additional, Jabado, N., additional, Dirks, P., additional, Huang, A., additional, Madden, J. R., additional, Donson, A. M., additional, Mirsky, D. M., additional, Dubuc, A., additional, Mack, S., additional, Gendoo, D., additional, Luu, B., additional, MacDonald, T., additional, Van Meter, T., additional, Croul, S., additional, Laureano, A., additional, Brugmann, W., additional, Denman, C., additional, Singh, H., additional, Huls, H., additional, Moyes, J., additional, Sandberg, D., additional, Silla, L., additional, Cooper, L., additional, and Lee, D., additional
Published: 2014
Full Text: View/download PDF

65. HIGH GRADE GLIOMAS AND DIPG

Author: Classen, C. F., primary, William, D., additional, Linnebacher, M., additional, Farhod, A., additional, Kedr, W., additional, Elsabe, B., additional, Fadel, S., additional, Van Gool, S., additional, De Vleeschouwer, S., additional, Koks, C., additional, Garg, A., additional, Ehrhardt, M., additional, Riva, M., additional, Agostinis, P., additional, Graf, N., additional, Yao, T.-W., additional, Yoshida, Y., additional, Zhang, J., additional, Ozawa, T., additional, James, D., additional, Nicolaides, T., additional, Kebudi, R., additional, Cakir, F. B., additional, Gorgun, O., additional, Agaoglu, F. Y., additional, Darendeliler, E., additional, Al-Kofide, A., additional, Al-Shail, E., additional, Khafaga, Y., additional, Al-Hindi, H., additional, Dababo, M., additional, Haq, A. U., additional, Anas, M., additional, Barria, M. G., additional, Siddiqui, K., additional, Hassounah, M., additional, Ayas, M., additional, van Zanten, S. V., additional, Jansen, M., additional, van Vuurden, D., additional, Huisman, M., additional, Vugts, D., additional, Hoekstra, O., additional, van Dongen, G., additional, Kaspers, G., additional, Cockle, J., additional, Ilett, E., additional, Scott, K., additional, Bruning-Richardson, A., additional, Picton, S., additional, Short, S., additional, Melcher, A., additional, Benesch, M., additional, Warmuth-Metz, M., additional, von Bueren, A. O., additional, Hoffmann, M., additional, Pietsch, T., additional, Kortmann, R.-D., additional, Eyrich, M., additional, Rutkowski, S., additional, Fruhwald, M. C., additional, Faber, J., additional, Kramm, C., additional, Porkholm, M., additional, Valanne, L., additional, Lonnqvist, T., additional, Holm, S., additional, Lannering, B., additional, Riikonen, P., additional, Wojcik, D., additional, Sehested, A., additional, Clausen, N., additional, Harila-Saari, A., additional, Schomerus, E., additional, Thorarinsdottir, H. K., additional, Lahteenmaki, P., additional, Arola, M., additional, Thomassen, H., additional, Saarinen-Pihkala, U. M., additional, Kivivuori, S.-M., additional, Buczkowicz, P., additional, Hoeman, C., additional, Rakopoulos, P., additional, Pajovic, S., additional, Morrison, A., additional, Bouffet, E., additional, Bartels, U., additional, Becher, O., additional, Hawkins, C., additional, Gould, T. W. A., additional, Rahman, C. V., additional, Smith, S. J., additional, Barrett, D. A., additional, Shakesheff, K. M., additional, Grundy, R. G., additional, Rahman, R., additional, Barua, N., additional, Cronin, D., additional, Gill, S., additional, Lowisl, S., additional, Hochart, A., additional, Maurage, C.-A., additional, Rocourt, N., additional, Vinchon, M., additional, Kerdraon, O., additional, Escande, F., additional, Grill, J., additional, Pick, V. K., additional, Leblond, P., additional, Burzynski, G., additional, Janicki, T., additional, Burzynski, S., additional, Marszalek, A., additional, Ramani, N., additional, Zaky, W., additional, Kannan, G., additional, Morani, A., additional, Sandberg, D., additional, Ketonen, L., additional, Maher, O., additional, Corrales-Medina, F., additional, Meador, H., additional, Khatua, S., additional, Brassesco, M., additional, Delsin, L., additional, Roberto, G., additional, Silva, C., additional, Ana, L., additional, Rego, E., additional, Scrideli, C., additional, Umezawa, K., additional, Tone, L., additional, Kim, S. J., additional, Kim, C.-Y., additional, Kim, I.-A., additional, Han, J. H., additional, Choi, B.-S., additional, Ahn, H. S., additional, Choi, H. S., additional, Haque, F., additional, Layfield, R., additional, Grundy, R., additional, Gandola, L., additional, Pecori, E., additional, Biassoni, V., additional, Schiavello, E., additional, Chiruzzi, C., additional, Spreafico, F., additional, Modena, P., additional, Bach, F., additional, Pignoli, E., additional, Massimino, M., additional, Drogosiewicz, M., additional, Dembowska-Baginska, B., additional, Jurkiewicz, E., additional, Filipek, I., additional, Perek-Polnik, M., additional, Swieszkowska, E., additional, Perek, D., additional, Bender, S., additional, Jones, D. T., additional, Warnatz, H.-J., additional, Hutter, B., additional, Zichner, T., additional, Gronych, J., additional, Korshunov, A., additional, Eils, R., additional, Korbel, J. O., additional, Yaspo, M.-L., additional, Lichter, P., additional, Pfister, S. M., additional, Yadavilli, S., additional, Becher, O. J., additional, Kambhampati, M., additional, Packer, R. J., additional, Nazarian, J., additional, Lechon, F. C., additional, Fowkes, L., additional, Khabra, K., additional, Martin-Retortillo, L. M., additional, Marshall, L. V., additional, Vaidya, S., additional, Koh, D.-M., additional, Leach, M. O., additional, Pearson, A. D., additional, Zacharoulis, S., additional, Schrey, D., additional, Barone, G., additional, Panditharatna, E., additional, Stampar, M., additional, Siu, A., additional, Gordish-Dressman, H., additional, Devaney, J., additional, Hwang, E. I., additional, Chung, A. H., additional, Mittapalli, R. K., additional, Elmquist, W. F., additional, Castel, D., additional, Debily, M.-A., additional, Philippe, C., additional, Truffaux, N., additional, Taylor, K., additional, Calmon, R., additional, Boddaert, N., additional, Le Dret, L., additional, Saulnier, P., additional, Lacroix, L., additional, Mackay, A., additional, Jones, C., additional, Puget, S., additional, Sainte-Rose, C., additional, Blauwblomme, T., additional, Varlet, P., additional, Entz-Werle, N., additional, Maugard, C., additional, Bougeard, G., additional, Nguyen, A., additional, Chenard, M. P., additional, Schneider, A., additional, Gaub, M. P., additional, Tsoli, M., additional, Vanniasinghe, A., additional, Luk, P., additional, Dilda, P., additional, Haber, M., additional, Hogg, P., additional, Ziegler, D., additional, Simon, S., additional, Monje, M., additional, Gurova, K., additional, Gudkov, A., additional, Zapotocky, M., additional, Churackova, M., additional, Malinova, B., additional, Zamecnik, J., additional, Kyncl, M., additional, Tichy, M., additional, Puchmajerova, A., additional, Stary, J., additional, Sumerauer, D., additional, Boult, J., additional, Vinci, M., additional, Perryman, L., additional, Box, G., additional, Jury, A., additional, Popov, S., additional, Ingram, W., additional, Eccles, S., additional, Robinson, S., additional, Emir, S., additional, Demir, H. A., additional, Bayram, C., additional, Cetindag, F., additional, Kabacam, G. B., additional, Fettah, A., additional, Li, J., additional, Jamin, Y., additional, Cummings, C., additional, Bamber, J., additional, Sinkus, R., additional, Nandhabalan, M., additional, Bjerke, L., additional, Burford, A., additional, von Bueren, A., additional, Baudis, M., additional, Clarke, P., additional, Collins, I., additional, Workman, P., additional, Olaciregui, N., additional, Mora, J., additional, Carcaboso, A., additional, Bullock, A., additional, Alonso, M., additional, de Torres, C., additional, Cruz, O., additional, Pencreach, E., additional, Moussalieh, F. M., additional, Guenot, D., additional, Namer, I., additional, Pollack, I., additional, Jakacki, R., additional, Butterfield, L., additional, Hamilton, R., additional, Panigrahy, A., additional, Potter, D., additional, Connelly, A., additional, Dibridge, S., additional, Whiteside, T., additional, Okada, H., additional, Ahsan, S., additional, Raabe, E., additional, Haffner, M., additional, Warren, K., additional, Quezado, M., additional, Ballester, L., additional, Eberhart, C., additional, Rodriguez, F., additional, Ramachandran, C., additional, Nair, S., additional, Quirrin, K.-W., additional, Khatib, Z., additional, Escalon, E., additional, Melnick, S., additional, Classen, C. F., additional, Hofmann, M., additional, Schmid, I., additional, Simon, T., additional, Maass, E., additional, Russo, A., additional, Fleischhack, G., additional, Becker, M., additional, Hauch, H., additional, Sander, A., additional, Grasso, C., additional, Berlow, N., additional, Liu, L., additional, Davis, L., additional, Huang, E., additional, Woo, P., additional, Tang, Y., additional, Ponnuswami, A., additional, Chen, S., additional, Huang, Y., additional, Hutt-Cabezas, M., additional, Dret, L., additional, Meltzer, P., additional, Mao, H., additional, Abraham, J., additional, Fouladi, M., additional, Svalina, M. N., additional, Wang, N., additional, Hulleman, E., additional, Li, X.-N., additional, Keller, C., additional, Spellman, P. T., additional, Pal, R., additional, Jansen, M. H. A., additional, Sewing, A. C. P., additional, Lagerweij, T., additional, Vuchts, D. J., additional, van Vuurden, D. G., additional, Caretti, V., additional, Wesseling, P., additional, Kaspers, G. J. L., additional, Cohen, K., additional, Pearl, M., additional, Kogiso, M., additional, Zhang, L., additional, Qi, L., additional, Lindsay, H., additional, Lin, F., additional, Berg, S., additional, Muscal, J., additional, Amayiri, N., additional, Tabori, U., additional, Campbel, B., additional, Bakry, D., additional, Aronson, M., additional, Durno, C., additional, Gallinger, S., additional, Malkin, D., additional, Qaddumi, I., additional, Musharbash, A., additional, Swaidan, M., additional, Al-Hussaini, M., additional, Shandilya, S., additional, McCully, C., additional, Murphy, R., additional, Akshintala, S., additional, Cole, D., additional, Macallister, R. P., additional, Cruz, R., additional, Widemann, B., additional, Salloum, R., additional, Smith, A., additional, Glaunert, M., additional, Ramkissoon, A., additional, Peterson, S., additional, Baker, S., additional, Chow, L., additional, Sandgren, J., additional, Pfeifer, S., additional, Popova, S., additional, Alafuzoff, I., additional, de Stahl, T. D., additional, Pietschmann, S., additional, Kerber, M. J., additional, Zwiener, I., additional, Henke, G., additional, Muller, K., additional, Sieow, N. Y.-F., additional, Hoe, R. H. M., additional, Tan, A. M., additional, Chan, M. Y., additional, Soh, S. Y., additional, Burrell, K., additional, Chornenkyy, Y., additional, Remke, M., additional, Golbourn, B., additional, Barzczyk, M., additional, Taylor, M., additional, Rutka, J., additional, Dirks, P., additional, Zadeh, G., additional, Agnihotri, S., additional, Hashizume, R., additional, Ihara, Y., additional, Andor, N., additional, Chen, X., additional, Lerner, R., additional, Huang, X., additional, Tom, M., additional, Solomon, D., additional, Mueller, S., additional, Petritsch, C., additional, Zhang, Z., additional, Gupta, N., additional, Waldman, T., additional, Dujua, A., additional, Co, J., additional, Hernandez, F., additional, Doromal, D., additional, Hegde, M., additional, Wakefield, A., additional, Brawley, V., additional, Grada, Z., additional, Byrd, T., additional, Chow, K., additional, Krebs, S., additional, Heslop, H., additional, Gottschalk, S., additional, Yvon, E., additional, Ahmed, N., additional, Cornilleau, G., additional, Paulsson, J., additional, Andreiuolo, F., additional, Guerrini-Rousseau, L., additional, Geoerger, B., additional, Vassal, G., additional, Ostman, A., additional, Parsons, D. W., additional, Trevino, L. R., additional, Gao, F., additional, Shen, X., additional, Hampton, O., additional, Kosigo, M., additional, Baxter, P. A., additional, Su, J. M., additional, Chintagumpala, M., additional, Dauser, R., additional, Adesina, A., additional, Plon, S. E., additional, Wheeler, D. A., additional, Lau, C. C., additional, Gielen, G., additional, Muehlen, A. z., additional, Kwiecien, R., additional, Wolff, J., additional, Lulla, R. R., additional, Laskowski, J., additional, Goldman, S., additional, Gopalakrishnan, V., additional, Fangusaro, J., additional, Kieran, M., additional, Fontebasso, A., additional, Papillon-Cavanagh, S., additional, Schwartzentruber, J., additional, Nikbakht, H., additional, Gerges, N., additional, Fiset, P.-O., additional, Bechet, D., additional, Faury, D., additional, De Jay, N., additional, Ramkissoon, L., additional, Corcoran, A., additional, Jones, D., additional, Sturm, D., additional, Johann, P., additional, Tomita, T., additional, Nagib, M., additional, Bendel, A., additional, Goumnerova, L., additional, Bowers, D. C., additional, Leonard, J. R., additional, Rubin, J. B., additional, Alden, T., additional, DiPatri, A., additional, Browd, S., additional, Leary, S., additional, Jallo, G., additional, Prados, M. D., additional, Banerjee, A., additional, Carret, A.-S., additional, Ellezam, B., additional, Crevier, L., additional, Klekner, A., additional, Bognar, L., additional, Hauser, P., additional, Garami, M., additional, Myseros, J., additional, Dong, Z., additional, Siegel, P. M., additional, Gump, W., additional, Ayyanar, K., additional, Ragheb, J., additional, Krieger, M., additional, Kiehna, E., additional, Robison, N., additional, Harter, D., additional, Gardner, S., additional, Handler, M., additional, Foreman, N., additional, Brahma, B., additional, MacDonald, T., additional, Malkin, H., additional, Chi, S., additional, Manley, P., additional, Bandopadhayay, P., additional, Greenspan, L., additional, Ligon, A., additional, Albrecht, S., additional, Ligon, K. L., additional, Majewski, J., additional, Jabado, N., additional, Cordero, F., additional, Halvorson, K., additional, Taylor, I., additional, Hutt, M., additional, Weingart, M., additional, Price, A., additional, Kantar, M., additional, Onen, S., additional, Kamer, S., additional, Turhan, T., additional, Kitis, O., additional, Ertan, Y., additional, Cetingul, N., additional, Anacak, Y., additional, Akalin, T., additional, Ersahin, Y., additional, Mason, G., additional, Ho, C., additional, Crozier, F., additional, Vezina, G., additional, Packer, R., additional, Hwang, E., additional, Gilheeney, S., additional, Millard, N., additional, DeBraganca, K., additional, Khakoo, Y., additional, Kramer, K., additional, Wolden, S., additional, Donzelli, M., additional, Fischer, C., additional, Petriccione, M., additional, Dunkel, I., additional, Afzal, S., additional, Fleming, A., additional, Larouche, V., additional, Zelcer, S., additional, Johnston, D. L., additional, Kostova, M., additional, Mpofu, C., additional, Decarie, J.-C., additional, Strother, D., additional, Lafay-Cousin, L., additional, Eisenstat, D., additional, Fryer, C., additional, Hukin, J., additional, Hsu, M., additional, Lasky, J., additional, Moore, T., additional, Liau, L., additional, Davidson, T., additional, Prins, R., additional, Hassal, T., additional, Baugh, J., additional, Kirkendall, J., additional, Doughman, R., additional, Leach, J., additional, Jones, B., additional, Miles, L., additional, Hargrave, D., additional, Jacques, T., additional, Savage, S., additional, Saunders, D., additional, Wallace, R., additional, Flutter, B., additional, Morgenestern, D., additional, Blanco, E., additional, Howe, K., additional, Lowdell, M., additional, Samuel, E., additional, Michalski, A., additional, Anderson, J., additional, Arakawa, Y., additional, Umeda, K., additional, Watanabe, K.-i., additional, Mizowaki, T., additional, Hiraoka, M., additional, Hiramatsu, H., additional, Adachi, S., additional, Kunieda, T., additional, Takagi, Y., additional, Miyamoto, S., additional, Venneti, S., additional, Santi, M., additional, Felicella, M. M., additional, Sullivan, L. M., additional, Dolgalev, I., additional, Martinez, D., additional, Perry, A., additional, Lewis, P. W., additional, Allis, D. C., additional, Thompson, C. B., additional, and Judkins, A. R., additional
Published: 2014
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66. TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma

Author: Remke, M. (Marc), Ramaswamy, E.A., Peacock, M. (Munro), Shih, D.J.H. (David J.), Koelsche, C. (Christian), Northcott, P.A. (Paul A.), Hill, N. (Nadia), Cavalli, S. (Silvia), Kool, M. (Marcel), Wang, X. (Xin), Mack, S. (Stephen), Barszczyk, M. (Mark), Morrissy, A.S. (A. Sorana), Wu, X. (Xiaochong), Agnihotri, S. (Sameer), Luu, P. (Phan), Jones, D. (David), Garzia, L. (Livia), Dubuc, A.M. (Adrian), Zhukova, N. (Nataliya), Vanner, R. (Robert), Kros, J.M. (Johan), French, P.J. (Pim), Meir, E.G. (Erwin) van, Vibhakar, R. (Rajeev), Zitterbart, K. (Karel), Chan, J.A. (Jennifer), Bognár, L. (László), Klekner, A. (Almos), Lach, B. (Boleslaw), Jung, S. (Shin), Saad, F. (Fred), Liau, L.M. (Linda), Albrecht, S. (Steffen), Zollo, M. (Maurizio), Cooper, M.K. (Michael), Thompson, R.C. (Reid), Delattre, O. (Olivier), Bourdeaut, F. (Franck), Doz, F.F. (François), Garami, M. (Miklós), Hauser, P. (Peter), Carlotti, C.G. (Carlos), Van Meter, T.E. (Timothy), Massimi, L. (Luca), Fults, D. (Daniel), Pomeroy, L.W. (Laura), Kumabe, T. (Toshiro), Ra, Y.S. (Young Shin), Leonard, J.R. (Jeffrey), Elbabaa, S.K. (Samer), Mora, J. (Jaume), Rubin, J.B. (Joshua), Cho, Y.-J. (Yoon-Jae), McLendon, R.E. (Roger), Bigner, D.D. (Darell), Eberhart, C.G. (Charles), Fouladi, M. (Maryam), Wechsler-Reya, R.J. (Robert), Faria, R. (Rui), Croul, S.E. (Sidney), Huang, A. (Anding), Bouffet, E. (Eric), Hawkins, C.E. (Cynthia), Dirks, M. (Maaike), Weiss, W.A. (William), Schüller, U. (Ulrich), Pollack, A. (Aaron), Rutkowski, P. (Piotr), Meyronet, D. (David), Jouvet, A. (Anne), Fèvre-Montange, M. (Michelle), Jabado, N. (Nada), Perek-Polnik, M. (Marta), Grajkowska, W.A. (Wieslawa), Kim, S.-K. (Seung-Ki), Rutka, J.T. (James), Malkin, E. (Elissa), Tabori, U. (Uri), Pfister, S.M. (Stefan), Korshunov, A. (Andrey), Deimling, A. (Andreas) von, Taylor, M.D. (Michael), Remke, M. (Marc), Ramaswamy, E.A., Peacock, M. (Munro), Shih, D.J.H. (David J.), Koelsche, C. (Christian), Northcott, P.A. (Paul A.), Hill, N. (Nadia), Cavalli, S. (Silvia), Kool, M. (Marcel), Wang, X. (Xin), Mack, S. (Stephen), Barszczyk, M. (Mark), Morrissy, A.S. (A. Sorana), Wu, X. (Xiaochong), Agnihotri, S. (Sameer), Luu, P. (Phan), Jones, D. (David), Garzia, L. (Livia), Dubuc, A.M. (Adrian), Zhukova, N. (Nataliya), Vanner, R. (Robert), Kros, J.M. (Johan), French, P.J. (Pim), Meir, E.G. (Erwin) van, Vibhakar, R. (Rajeev), Zitterbart, K. (Karel), Chan, J.A. (Jennifer), Bognár, L. (László), Klekner, A. (Almos), Lach, B. (Boleslaw), Jung, S. (Shin), Saad, F. (Fred), Liau, L.M. (Linda), Albrecht, S. (Steffen), Zollo, M. (Maurizio), Cooper, M.K. (Michael), Thompson, R.C. (Reid), Delattre, O. (Olivier), Bourdeaut, F. (Franck), Doz, F.F. (François), Garami, M. (Miklós), Hauser, P. (Peter), Carlotti, C.G. (Carlos), Van Meter, T.E. (Timothy), Massimi, L. (Luca), Fults, D. (Daniel), Pomeroy, L.W. (Laura), Kumabe, T. (Toshiro), Ra, Y.S. (Young Shin), Leonard, J.R. (Jeffrey), Elbabaa, S.K. (Samer), Mora, J. (Jaume), Rubin, J.B. (Joshua), Cho, Y.-J. (Yoon-Jae), McLendon, R.E. (Roger), Bigner, D.D. (Darell), Eberhart, C.G. (Charles), Fouladi, M. (Maryam), Wechsler-Reya, R.J. (Robert), Faria, R. (Rui), Croul, S.E. (Sidney), Huang, A. (Anding), Bouffet, E. (Eric), Hawkins, C.E. (Cynthia), Dirks, M. (Maaike), Weiss, W.A. (William), Schüller, U. (Ulrich), Pollack, A. (Aaron), Rutkowski, P. (Piotr), Meyronet, D. (David), Jouvet, A. (Anne), Fèvre-Montange, M. (Michelle), Jabado, N. (Nada), Perek-Polnik, M. (Marta), Grajkowska, W.A. (Wieslawa), Kim, S.-K. (Seung-Ki), Rutka, J.T. (James), Malkin, E. (Elissa), Tabori, U. (Uri), Pfister, S.M. (Stefan), Korshunov, A. (Andrey), Deimling, A. (Andreas) von, and Taylor, M.D. (Michael)
Abstract: Telomerase reverse transcriptase (TERT) promoter mutations were recently shown to drive telomerase activity in various cancer types, including medulloblastoma. However, the clinical and biological implications of TERT mutations in medulloblastoma have not been described. Hence, we sought to describe these mutations and their impact in a subgroup-specific manner. We analyzed the TERT promoter by direct sequencing and genotyping in 466 medulloblastomas. The mutational distributions were determined according to subgroup affiliation, demographics, and clinical, prognostic, and molecular features. Integrated genomics approaches were used to identify specific somatic copy number alterations in TERT promoter-mutated and wild-type tumors. Overall, TERT promoter mutations were identified in 21 % of medulloblastomas. Strikingly, the highest frequencies of TERT mutations were observed in SHH (83 %; 55/66) and WNT (31 %; 4/13) medulloblastomas derived from adult patients. Group 3 and Group 4 harbored this alteration in <5 % of cases and showed no association with
Published: 2013
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67. TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma

Author: Remke, M, Ramaswamy, V, Peacock, J, Shih, DJH, Koelsche, C, Northcott, PA, Hill, N, Cavalli, FMG, Kool, Mirjam, Wang, X, Mack, SC, Barszczyk, M, Morrissy, AS, Wu, XC, Agnihotri, S, Luu, B, Jones, DTW, Garzia, L, Dubuc, AM, Zhukova, N, Vanner, R, Kros, J.M., French, Pim, van Meir, EG, Vibhakar, R, Zitterbart, K, Chan, JA, Bognar, L, Klekner, A, Lach, B, Jung, S, Saad, AG, Albrecht, S, Liau, LM, Zollo, M, Cooper, MK, Thompson, RC, Delattre, OO, Bourdeaut, F, Doz, FF, Garami, M, Hauser, P, Carlotti, CG, Van Meter, TE, Massimi, L, Fults, D, Pomeroy, SL, Kumabe, T, Ra, YS, Leonard, JR, Elbabaa, SK, Mora, J, Rubin, JB, Cho, YJ, McLendon, RE, Bigner, DD, Eberhart, CG, Fouladi, M, Wechsler-Reya, RJ, Faria, CC, Croul, SE, Huang, A, Bouffet, E, Hawkins, CE, Dirks, PB, Weiss, WA, Schuller, U, Pollack, IF, Rutkowski, S, Meyronet, D, Jouvet, A, Fevre-Montange, M, Jabado, N, Perek-Polnik, M, Grajkowska, WA, Kim, SK, Rutka, JT, Malkin, D, Tabori, U, Pfister, SM, Korshunov, A, von Deimling, A, Taylor, MD, Remke, M, Ramaswamy, V, Peacock, J, Shih, DJH, Koelsche, C, Northcott, PA, Hill, N, Cavalli, FMG, Kool, Mirjam, Wang, X, Mack, SC, Barszczyk, M, Morrissy, AS, Wu, XC, Agnihotri, S, Luu, B, Jones, DTW, Garzia, L, Dubuc, AM, Zhukova, N, Vanner, R, Kros, J.M., French, Pim, van Meir, EG, Vibhakar, R, Zitterbart, K, Chan, JA, Bognar, L, Klekner, A, Lach, B, Jung, S, Saad, AG, Albrecht, S, Liau, LM, Zollo, M, Cooper, MK, Thompson, RC, Delattre, OO, Bourdeaut, F, Doz, FF, Garami, M, Hauser, P, Carlotti, CG, Van Meter, TE, Massimi, L, Fults, D, Pomeroy, SL, Kumabe, T, Ra, YS, Leonard, JR, Elbabaa, SK, Mora, J, Rubin, JB, Cho, YJ, McLendon, RE, Bigner, DD, Eberhart, CG, Fouladi, M, Wechsler-Reya, RJ, Faria, CC, Croul, SE, Huang, A, Bouffet, E, Hawkins, CE, Dirks, PB, Weiss, WA, Schuller, U, Pollack, IF, Rutkowski, S, Meyronet, D, Jouvet, A, Fevre-Montange, M, Jabado, N, Perek-Polnik, M, Grajkowska, WA, Kim, SK, Rutka, JT, Malkin, D, Tabori, U, Pfister, SM, Korshunov, A, von Deimling, A, and Taylor, MD
Abstract: Telomerase reverse transcriptase (TERT) promoter mutations were recently shown to drive telomerase activity in various cancer types, including medulloblastoma. However, the clinical and biological implications of TERT mutations in medulloblastoma have not been described. Hence, we sought to describe these mutations and their impact in a subgroup-specific manner. We analyzed the TERT promoter by direct sequencing and genotyping in 466 medulloblastomas. The mutational distributions were determined according to subgroup affiliation, demographics, and clinical, prognostic, and molecular features. Integrated genomics approaches were used to identify specific somatic copy number alterations in TERT promoter-mutated and wild-type tumors. Overall, TERT promoter mutations were identified in 21 % of medulloblastomas. Strikingly, the highest frequencies of TERT mutations were observed in SHH (83 %; 55/66) and WNT (31 %; 4/13) medulloblastomas derived from adult patients. Group 3 and Group 4 harbored this alteration in < 5 % of cases and showed no association with increased patient age. The prognostic implications of these mutations were highly subgroup-specific. TERT mutations identified a subset with good and poor prognosis in SHH and Group 4 tumors, respectively. Monosomy 6 was mostly restricted to WNT tumors without TERT mutations. Hallmark SHH focal copy number aberrations and chromosome 10q deletion were mutually exclusive with TERT mutations within SHH tumors. TERT promoter mutations are the most common recurrent somatic point mutation in medulloblastoma, and are very highly enriched in adult SHH and WNT tumors. TERT mutations define a subset of SHH medulloblastoma with distinct demographics, cytogenetics, and outcomes.
Published: 2013

68. LBA19_PR - CNS tumours The first study of dabrafenib in pediatric patients with BRAF V600–mutant relapsed or refractory low-grade gliomas

Author: Kieran, M.W., Bouffet, E., Tabori, U., Broniscer, A., Cohen, K., Hansford, J., Geoerger, B., Hingorani, P., Dunkel, I., Russo, M., Tseng, L., Liu, Q., Nebot, N., Whitlock, J., and Hargrave, D.
Published: 2016
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69. CONTRIBUTION OF DNA COPY-NUMBER VARIATION (CNV) TO CANCER SUSCEPTIBILITY AND LARGE-SCALE GENOME ALTERATIONS IN OSTEOSARCOMA (OS)

Author: Pasic, I, Shlien, A, Novokmet, A, Zhang, C, Tabori, U, Pinto, D, Scherer, S W, Malkin, D, Pasic, I, Shlien, A, Novokmet, A, Zhang, C, Tabori, U, Pinto, D, Scherer, S W, and Malkin, D
Abstract: Introduction: OS, a common Li-Fraumeni syndrome (LFS)-associated neoplasm, is a common bone malignancy of children and adolescents. Sporadic OS is also characterized by young age of onset and high genomic instability, suggesting a genetic contribution to disease. This study examined the contribution of novel DNA structural variation elements, CNVs, to OS susceptibility. Given our finding of excessive constitutional DNA CNV in LFS patients, which often coincide with cancer-related genes, we hypothesized that constitutional CNV may also provide clues about the aetiology of LFS-related sporadic neoplasms like OS. Methods: CNV in blood DNA of 26 patients with sporadic OS was compared to that of 263 normal control samples from the International HapMap project, as well as 62 local controls. Analysis was performed on DNA hybridized to Affymetrix genome-wide human SNP array 6.0 by Partek Genomic Suite. Results: There was no detectable difference in average number of CNVs, CNV length, and total structural variation (product of average CNV number and length) between individuals with OS and controls. While this data is preliminary (small sample size), it argues against the presence of constitutional genomic instability in individuals with sporadic OS. Conclusion: We found that the majority of tumours from patients with sporadic OS show CN loss at chr3q13.31, raising the possibility that chr3q13.31 may represent a “driver” region in OS aetiology. In at least one OS tumour, which displays CN loss at chr3q13.31, we demonstrate decreased expression of a known tumour suppressor gene located at chr3q13.31. We are investigating the role ofchr3q13.31 in development of OS.
Published: 2008

70. PEDIATRICS CLINICAL RESEARCH

Author: Antony, R., primary, Zagardo, M., additional, Gujrati, M., additional, Lin, J., additional, Antony, R., additional, Al-Rahawan, M., additional, Broniscer, A., additional, Bhardwaj, R., additional, Hampton, C., additional, Ozols, V., additional, Chakravadhanula, M., additional, Bouffet, E., additional, Hawkins, C., additional, Scheinemann, K., additional, Zelcer, S., additional, Johnston, D., additional, Lafay-Cousin, L., additional, Larouche, V., additional, Jabado, N., additional, Carret, A. S., additional, Hukin, J., additional, Eisenstat, D., additional, Pond, G., additional, Poskitt, K., additional, Wilson, B., additional, Bartels, U., additional, Tabori, U., additional, Dhall, G., additional, Haley, K., additional, Finlay, J., additional, Rushing, T., additional, Sposto, R., additional, Seeger, R., additional, Garvin, J., additional, Rupani, K., additional, Stark, E., additional, Anderson, R., additional, Feldstein, N., additional, Grill, J., additional, Hargrave, D., additional, Massimino, M., additional, Jaspan, T., additional, Varlet, P., additional, Jones, C., additional, Morgan, P., additional, Le Deley, M. C., additional, Azizi, A., additional, Canete, A., additional, Saran, F., additional, Bachir, J., additional, Bubuteishvili-Pacaud, L., additional, Rousseau, R., additional, Vassal, G., additional, Gupta, S., additional, Robinson, N., additional, Dhir, N., additional, Wong, K., additional, Zhou, S., additional, Kumabe, T., additional, Kawaguchi, T., additional, Saito, R., additional, Kanamori, M., additional, Yamashita, Y., additional, Sonoda, Y., additional, Tominaga, T., additional, Miyagawa, T., additional, Nwachukwu, C., additional, Youland, R., additional, Laack, N., additional, Filipek, I., additional, Drogosiewicz, M., additional, Polnik, M. P.-, additional, Swieszkowska, E., additional, Dembowska-Baginska, B., additional, Jurkiewicz, E., additional, Perek, D., additional, Grajkowska, W., additional, Roszkowski, M., additional, Sobol, G., additional, Musiol, K., additional, Wachowiak, J., additional, Kazmierczak, B., additional, Pogorzelski, J. P. -, additional, Mlynarski, W., additional, Szewczyk, B. Z.-, additional, Wysocki, M., additional, Niedzielska, E., additional, Kowalczyk, J., additional, Slusarz, H. W. -, additional, Balwierz, W., additional, Czepko, E. Z. -, additional, Szolkiewicz, A., additional, Perek-Polnik, M., additional, Lastowska, M., additional, Chojnacka, M., additional, Tarasinska, M., additional, Perreault, S., additional, Chao, K., additional, Ramaswamy, V., additional, Shih, D., additional, Remke, M., additional, Luu, B., additional, Schubert, S., additional, Fisher, P., additional, Partap, S., additional, Vogel, H., additional, Taylor, M., additional, Goumnerova, L., additional, Cho, Y.-J., additional, Robison, N., additional, Brown, R., additional, Cloughesy, T., additional, Davidson, T. B., additional, Krieger, M., additional, Berger, M., additional, Perry, A., additional, Gilles, F., additional, Finlay, J. L., additional, Khemani, J., additional, Britt, B., additional, Grimm, J., additional, Ruge, M. I., additional, Blau, T., additional, Hafkemeyer, V., additional, Hamisch, C., additional, Klinger, K., additional, Simon, T., additional, Sadighi, Z., additional, Ellezam, B., additional, Guindani, M., additional, Ater, J., additional, Shimizu, Y., additional, Arai, H., additional, Miyajima, M., additional, Shimoji, K., additional, Kondo, A., additional, Shinohara, E., additional, Perkins, S., additional, DeWees, T., additional, Slavc, I., additional, Chocholous, M., additional, Leiss, U., additional, Haberler, C., additional, Peyrl, A., additional, Azizi, A. A., additional, Dieckmann, K., additional, Woehrer, A., additional, Dorfer, C., additional, Czech, T., additional, Spence, T., additional, Picard, D., additional, Barszczyk, M., additional, Kim, S.-K., additional, Ra, Y.-S., additional, Fangusaro, J., additional, Toledano, H., additional, Nakamura, H., additional, Fan, X., additional, Muraszko, K. M., additional, Ng, H.-K., additional, Halliday, W., additional, Shago, M., additional, Hawkins, C. E., additional, Huang, A., additional, Suzuki, M., additional, van Zanten, S. V., additional, Jansen, M., additional, van Vuurden, D., additional, Hulleman, E., additional, Idema, S., additional, Noske, D., additional, Wolf, N., additional, Hendrikse, H., additional, Vandertop, P., additional, Kaspers, G. J., additional, Muller, K., additional, Schlamann, A., additional, Warmuth-Metz, M., additional, Pietsch, T., additional, Pietschmann, S., additional, Kortmann, R.-D., additional, Kramm, C. M., additional, von Bueren, A. O., additional, Walston, S., additional, Williams, T., additional, Hamstra, D., additional, Oh, K., additional, Pelloski, C., additional, Zhukova, N., additional, Pole, J., additional, Mistry, M., additional, Fried, I., additional, Lapperiere, N., additional, Dirks, P., additional, An, J., additional, Alon, N., additional, Nathan, P., additional, Greenberg, M., additional, and Malkin, D., additional
Published: 2013
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71. Optic pathway gliomas in adolescence--time to challenge treatment choices?

Author: Lee Chong, A., primary, Pole, J. D., additional, Scheinemann, K., additional, Hukin, J., additional, Tabori, U., additional, Huang, A., additional, Bouffet, E., additional, and Bartels, U., additional
Published: 2013
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72. EPENDYMOMA

Author: Zaghloul, M., primary, Elbeltagy, M., additional, Mousa, A., additional, Eldebawy, E., additional, Amin, A., additional, Pavelka, Z., additional, Vranova, V., additional, Valaskova, I., additional, Tomasikova, L., additional, Oltova, A., additional, Ventruba, J., additional, Mackerle, Z., additional, Kren, L., additional, Skotakova, J., additional, Zitterbart, K., additional, Sterba, J., additional, Milde, T., additional, Kleber, S., additional, Korshunov, A., additional, Witt, H., additional, Hielscher, T., additional, Koch, P., additional, Koch, H.-G., additional, Jugold, M., additional, Deubzer, H. E., additional, Oehme, I., additional, Lodrini, M., additional, Grone, H.-J., additional, Benner, A., additional, Brustle, O., additional, Gilbertson, R. J., additional, von Deimling, A., additional, Kulozik, A. E., additional, Pfister, S. M., additional, Ana, M.-V., additional, Witt, O., additional, Kool, M., additional, Mack, S. C., additional, Taylor, M. D., additional, Fouyssac, F., additional, Schmitt, E., additional, Mansuy, L., additional, Marchal, J.-C., additional, Coffinet, L., additional, Bernier, V., additional, Chastagner, P., additional, Sperl, D., additional, Zacharoulis, S., additional, Massimino, M., additional, Schiavello, E., additional, Pizer, B., additional, Piette, C., additional, Kitanovski, L., additional, von Hoff, K., additional, Quehenberger, F., additional, Rutkowski, S., additional, Benesch, M., additional, Tzaridis, T.-D., additional, Bender, S., additional, Pfaff, E., additional, Barbus, S., additional, Bageritz, J., additional, Jones, D.-T.-W., additional, Kulozik, A., additional, Lichter, P., additional, Pfister, S.-M., additional, Song, S.-H., additional, Kang, C.-W., additional, Kim, S.-H., additional, Bandopadhayay, P., additional, Ullrich, N., additional, Goumnerova, L., additional, Scott, R. M., additional, Silvera, V. M., additional, Ligon, K. L., additional, Marcus, K. J., additional, Robison, N., additional, Manley, P. E., additional, Chi, S., additional, Kieran, M. W., additional, Biassoni, V., additional, Pierani, P., additional, Cesaro, S., additional, Maura, M., additional, Mack, S., additional, Jager, N., additional, Jones, D. T. W., additional, Stutz, A., additional, Northcott, P. A., additional, Fults, D. W., additional, Gupta, N., additional, Karajannis, M., additional, Rutka, J. T., additional, Korbel, J., additional, de Rezende, A. C. P., additional, Chen, M. J., additional, da Silva, N. S., additional, Cappellano, A., additional, Cavalheiro, S., additional, Weltman, E., additional, Currle, S., additional, Thiruvenkatam, R., additional, Murugesan, M., additional, Kranenburg, T., additional, Phoenix, T., additional, Gupta, K., additional, Gilbertson, R., additional, Rogers, H., additional, Kilday, J.-P., additional, Mayne, C., additional, Ward, J., additional, Adamowicz-Brice, M., additional, Schwalbe, E., additional, Clifford, S., additional, Coyle, B., additional, Grundy, R., additional, Mitra, B., additional, Domerg, C., additional, Andreiuolo, F., additional, Osteso-Ibanez, T., additional, Mauguen, A., additional, Varlet, P., additional, Le Deley, M.-C., additional, Lowe, J., additional, Ellison, D. W., additional, Grill, J., additional, Grundy, R. G., additional, Fleischhack, G., additional, Pajtler, K., additional, Zimmermann, M., additional, Warmuth-Metz, M., additional, Kortmann, R.-D., additional, Pietsch, T., additional, Faldum, A., additional, Bode, U., additional, Gandola, L., additional, Pecori, E., additional, Scarzello, G., additional, Barra, S., additional, Mascarin, M., additional, Scoccianti, S., additional, Mussano, A., additional, Garre, M. L., additional, Jacopo, S., additional, Viscardi, E., additional, Balter, R., additional, Bertin, D., additional, Giangaspero, F., additional, Pearlman, M., additional, Khatua, S., additional, Van Meter, T., additional, Koul, D., additional, Yung, A., additional, Paulino, A., additional, Su, J., additional, Dauser, R., additional, Whitehead, W., additional, Teh, B., additional, Chintagumpala, M., additional, Perek, D., additional, Drogosiewicz, M., additional, Filipek, I., additional, Polnik, M. P., additional, Baginska, B. D., additional, Wachowiak, J., additional, Kazmierczak, B., additional, Sobol, G., additional, Musiol, K., additional, Kowalczyk, J., additional, Slusarz, H. W., additional, Peregud-Pogorzelski, J., additional, Grajkowska, W., additional, Roszkowski, M., additional, Teo, W.-Y., additional, Okcu, F., additional, Mahajan, A., additional, Adesina, A., additional, Jea, A., additional, Bollo, R., additional, Paulino, A. C., additional, Velez-Char, N., additional, Doerner, E., additional, Muehlen, A. z., additional, Vladimirova, V., additional, Kortmann, R., additional, Friedrich, C., additional, von Bueren, A. O., additional, Barszczyk, M., additional, Buczkowicz, P., additional, Morrison, A., additional, Tabori, U., additional, Hawkins, C., additional, Krajewski, K., additional, Kammler, G., additional, von Bueren, A., additional, Krauss, J., additional, Ferreira, C., additional, Dieffenbach, G., additional, Barbosa, C., additional, Cuny, P., additional, Piccinin, E., additional, Brenca, M., additional, Lorenzetto, E., additional, Sardi, I., additional, Genitori, L., additional, Pollo, B., additional, Maestro, R., additional, Modena, P., additional, MacDonald, S., additional, Ebb, D., additional, Lavally, B., additional, Yeap, B., additional, Marcus, K., additional, Tarbell, N., additional, Yock, T., additional, Schittone, S., additional, Donson, A., additional, Birks, D., additional, Amani, V., additional, Griesinger, A., additional, Handler, M., additional, Madey, M., additional, Merchant, T., additional, Foreman, N., additional, Hukin, J., additional, Ailon, T., additional, Dunham, C., additional, Carret, A.-S., additional, McNeely, P. D., additional, Zelcer, S., additional, Wilson, B., additional, Lafay-Cousin, L., additional, Johnston, D., additional, Eisenstat, D., additional, Silva, M., additional, Jabado, N., additional, Yip, S., additional, Goddard, K., additional, Fryer, C., additional, Hendson, G., additional, Dunn, S., additional, Singhal, A., additional, Lassen-Ramshad, Y., additional, Vestergaard, A., additional, Seiersen, K., additional, Schultz, H. P., additional, Hoeyer, M., additional, Petersen, J. B., additional, Moreno, L., additional, Popov, S., additional, Jury, A., additional, Al Sarraj, S., additional, Jones, C., additional, Bowers, D., additional, Gargan, L., additional, Horton, C. J., additional, Rakheja, D., additional, Margraf, L., additional, Yeung, J., additional, Hamilton, R., additional, Okada, H., additional, Jakacki, R., additional, Pollack, I., additional, Fleming, A., additional, Saint-Martin, C., additional, Freeman, C., additional, Albrecht, S., additional, and Montes, J.-L., additional
Published: 2012
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73. BIOLOGY

Author: Kim, J. H., primary, Song, H. B., additional, Kim, D. H., additional, Park, K. D., additional, Kim, J. H., additional, Lee, B. J., additional, Khatua, S., additional, Kalkan, E., additional, Brown, R., additional, Pearlman, M., additional, Vats, T., additional, Abela, L., additional, Fiaschetti, G., additional, Shalaby, T., additional, Grunder, E., additional, Ma, M., additional, Grahlert, J., additional, Baumgartner, M., additional, Siler, U., additional, Nonoguchi, N., additional, Ohgaki, H., additional, Grotzer, M., additional, Adachi, J.-i., additional, Suzuki, T., additional, Fukuoka, K., additional, Yanagisawa, T., additional, Mishima, K., additional, Koga, T., additional, Matsutani, M., additional, Nishikawa, R., additional, Sardi, I., additional, Giunti, L., additional, Bresci, C., additional, Cardellicchio, S., additional, Da Ros, M., additional, Buccoliero, A. M., additional, Farina, S., additional, Arico, M., additional, Genitori, L., additional, Massimino, M., additional, Filippi, L., additional, Erdreich-Epstein, A., additional, Zhou, H., additional, Ren, X., additional, Schur, M., additional, Davidson, T. B., additional, Ji, L., additional, Sposto, R., additional, Asgharzadeh, S., additional, Tong, Y., additional, White, E., additional, Murugesan, M., additional, Nimmervoll, B., additional, Wang, M., additional, Marino, D., additional, Ellison, D., additional, Finkelstein, D., additional, Pounds, S., additional, Malkin, D., additional, Gilbertson, R., additional, Eden, C., additional, Ju, B., additional, Phoenix, T., additional, Poppleton, H., additional, Lessman, C., additional, Taylor, M., additional, la Marca, G., additional, Malvagia, S., additional, Fratoni, V., additional, Giovannini, M. G., additional, Giangaspero, F., additional, Badiali, M., additional, Gleize, V., additional, Paris, S., additional, Moi, L., additional, Elhouadani, S., additional, Arcella, A., additional, Morace, R., additional, Antonelli, M., additional, Buttarelli, F., additional, Mokhtari, K., additional, Sanson, M., additional, Smith, S., additional, Ward, J., additional, Wilson, M., additional, Rahman, C., additional, Rose, F., additional, Peet, A., additional, Macarthur, D., additional, Grundy, R., additional, Rahman, R., additional, Venkatraman, S., additional, Birks, D., additional, Balakrishnan, I., additional, Alimova, I., additional, Harris, P., additional, Patel, P., additional, Foreman, N., additional, Vibhakar, R., additional, Wu, H., additional, Zhou, Q., additional, Wang, D., additional, Wang, G., additional, Dang, D., additional, Pencreach, E., additional, Nguyen, A., additional, Guerin, E., additional, Lasthaus, C., additional, Guenot, D., additional, Entz-Werle, N., additional, Unland, R., additional, Schlosser, S., additional, Farwick, N., additional, Plagemann, T., additional, Richter, G., additional, Juergens, H., additional, Fruehwald, M., additional, Chien, C.-L., additional, Lee, Y.-H., additional, Lin, C.-I., additional, Hsieh, J.-Y., additional, Lin, S.-C., additional, Wong, T.-T., additional, Ho, D. M.-T., additional, Wang, H.-W., additional, Lagah, S., additional, Tan, I.-L., additional, Malcolm, S., additional, Majani, Y., additional, van Vuurden, D. G., additional, Aronica, E., additional, Wedekind, L. E., additional, Hulleman, E., additional, Biesmans, D., additional, Bugiani, M., additional, Vandertop, W. P., additional, Kaspers, G. J. L., additional, Wurdinger, T., additional, Noske, D. P., additional, Van der Stoop, P. M., additional, Shukla, S., additional, Kuipers, G. K., additional, Slotman, B. J., additional, Cloos, J., additional, Sun, T., additional, Warrington, N., additional, Luo, J., additional, Ganzhorn, S., additional, Tabori, U., additional, Druley, T., additional, Gutmann, D., additional, Rubin, J., additional, Castelo-Branco, P., additional, Choufani, S., additional, Mack, S., additional, Galagher, D., additional, Zhang, C., additional, Lipman, T., additional, Zhukova, N., additional, Martin, D., additional, Merino, D., additional, Wasserman, J., additional, Samuel, C., additional, Alon, N., additional, Hitzler, J., additional, Wang, J. C. Y., additional, Keller, G., additional, Dirks, P. B., additional, Pfister, S., additional, Taylor, M. D., additional, Weksberg, R., additional, Leblond, P., additional, Meignan, S., additional, Dewitte, A., additional, Le Tinier, F., additional, Wattez, N., additional, Lartigau, E., additional, Lansiaux, A., additional, Hanson, R., additional, Gordon, I., additional, Zhao, S., additional, Camphausen, K., additional, Warren, K., additional, Warrington, N. M., additional, Gutmann, D. H., additional, Rubin, J. B., additional, Jaillet, M., additional, Kovacs, Z., additional, Martin-Fiori, E., additional, Bernasconi, M., additional, Werner, B., additional, Dyberg, C., additional, Baryawno, N., additional, Milosevic, J., additional, Wickstrom, M., additional, Northcott, P. A., additional, Kool, M., additional, Kogner, P., additional, Johnsen, J. I., additional, Reynolds, G., additional, Davies, N., additional, Arvanitis, T., additional, Zoghbi, A., additional, Meisterernst, M., additional, Fruehwald, M. C., additional, Kerl, K., additional, Orr, B., additional, Haffner, M., additional, Nelson, W., additional, Yegnasubramanian, S., additional, Eberhart, C., additional, Fotovati, A., additional, Abu-Ali, S., additional, Wang, P.-S., additional, Deleyrolle, L., additional, Lee, C., additional, Triscott, J., additional, Chen, J., additional, Franciosi, S., additional, Nakamura, Y., additional, Sugita, Y., additional, Uchiumi, T., additional, Kuwano, M., additional, Leavitt, B., additional, Singh, S., additional, Jury, A., additional, Jones, C., additional, Wakimoto, H., additional, Reynolds, B., additional, Pallen, C., additional, Dunn, S., additional, Fletcher, S., additional, Levine, J., additional, Li, M., additional, Kagawa, N., additional, Hirayama, R., additional, Chiba, Y., additional, Kijima, N., additional, Arita, H., additional, Kinoshita, M., additional, Hashimoto, N., additional, Izumoto, S., additional, Maruno, M., additional, and Yoshimine, T., additional
Published: 2012
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74. HIGH GRADE GLIOMAS

Author: Leonard, A., primary, Wolff, J., additional, Sengupta, R., additional, Marassa, J., additional, Piwnica-Worms, D., additional, Rubin, J., additional, Pollack, I., additional, Jakacki, R., additional, Butterfield, L., additional, Okada, H., additional, Fangusaro, J., additional, Warren, K. E., additional, Mullins, C., additional, Jurgen, P., additional, Julia, S., additional, Friedrich, C. C., additional, Keir, S., additional, Saling, J., additional, Roskoski, M., additional, Friedman, H., additional, Bigner, D., additional, Moertel, C., additional, Olin, M., additional, Dahlheimer, T., additional, Gustafson, M., additional, Sumstad, D., additional, McKenna, D., additional, Low, W., additional, Nascene, D., additional, Dietz, A., additional, Ohlfest, J., additional, Sturm, D., additional, Witt, H., additional, Hovestadt, V., additional, Quan, D. A. K., additional, Jones, D. T. W., additional, Konermann, C., additional, Pfaff, E., additional, Korshunov, A., additional, Rizhova, M., additional, Milde, T., additional, Witt, O., additional, Zapatka, M., additional, Collins, V. P., additional, Kool, M., additional, Reifenberger, G., additional, Lichter, P., additional, Lindroth, A. M., additional, Plass, C., additional, Jabado, N., additional, Pfister, S. M., additional, Pizer, B., additional, Salehzadeh, A., additional, Brodbelt, A., additional, Mallucci, C., additional, Brassesco, M., additional, Pezuk, J., additional, Morales, A., additional, de Oliveira, J., additional, Roberto, G., additional, Umezawa, K., additional, Valera, E., additional, Rego, E., additional, Scrideli, C., additional, Tone, L., additional, Veringa, S. J. E., additional, Van Vuurden, D. G., additional, Wesseling, P., additional, Vandertop, W. P., additional, Noske, D. P., additional, Wurdinger, T., additional, Kaspers, G. J. L., additional, Hulleman, E., additional, Wright, K., additional, Broniscer, A., additional, Bendel, A., additional, Bowers, D., additional, Crawford, J., additional, Fisher, P., additional, Hassall, T., additional, Armstrong, G., additional, Baker, J., additional, Qaddoumi, I., additional, Robinson, G., additional, Wetmore, C., additional, Klimo, P., additional, Boop, F., additional, Onar-Thomas, A., additional, Ellison, D., additional, Gajjar, A., additional, Cruz, O., additional, de Torres, C., additional, Sunol, M., additional, Rodriguez, E., additional, Alonso, L., additional, Parareda, A., additional, Cardesa, T., additional, Salvador, H., additional, Celis, V., additional, Guillen, A., additional, Garcia, G., additional, Muchart, J., additional, Trampal, C., additional, Martin, M. L., additional, Rebollo, M., additional, Mora, J., additional, Piotrowski, A., additional, Kowalska, A., additional, Coyle, P., additional, Smith, S., additional, Rogers, H., additional, Macarthur, D., additional, Grundy, R., additional, Puccetti, D., additional, Salamat, S., additional, Kennedy, T., additional, Patel, N., additional, Bradley, K., additional, Casey, K., additional, Iskandar, B., additional, Nakano, Y., additional, Okada, K., additional, Osugi, Y., additional, Yamasaki, K., additional, Fujisaki, H., additional, Fukushima, H., additional, Inoue, T., additional, Matsusaka, Y., additional, Sakamoto, H., additional, Hara, J., additional, De Vleeschouwer, S., additional, Ardon, H., additional, Van Calenbergh, F., additional, Sciot, R., additional, Wilms, G., additional, Van Loon, J., additional, Goffin, J., additional, Van Gool, S., additional, Rusinak, D., additional, Knight, P., additional, Onel, K., additional, Wargowski, D., additional, Stettner, A., additional, Al-Ghafari, A., additional, Punjaruk, W., additional, Coyle, B., additional, Kerr, I., additional, Xipell, E., additional, Rodriguez, M., additional, Gonzalez-Huarriz, M., additional, Tunon, M. T., additional, Zazpe, I., additional, Tejada-Solis, S., additional, Diez-Valle, R., additional, Fueyo, J., additional, Gomez-Manzano, C., additional, Alonso, M. M., additional, Pastakia, D., additional, McCully, C., additional, Murphy, R., additional, Bacher, J., additional, Thomas, M., additional, Steffen-Smith, E., additional, Saleem, K., additional, Waldbridge, S., additional, Widemann, B., additional, Warren, K., additional, Miele, E., additional, Buttarelli, F., additional, Arcella, A., additional, Begalli, F., additional, Po, A., additional, Baldi, C., additional, Carissimo, G., additional, Antonelli, M., additional, Donofrio, V., additional, Morra, I., additional, Nozza, P., additional, Gulino, A., additional, Giangaspero, F., additional, Ferretti, E., additional, Elens, I., additional, Pauwels, F., additional, Fritzell, S., additional, Eberstal, S., additional, Sanden, E., additional, Visse, E., additional, Darabi, A., additional, Siesjo, P., additional, McDonald, P., additional, Wrogemann, J., additional, Krawitz, S., additional, Del Bigio, M., additional, Eisenstat, D., additional, Kwiecien, R., additional, Pietsch, T., additional, Faldum, A., additional, Kortmann, R.-D., additional, Warmuth-Metz, M., additional, Rutkowski, S., additional, Slavc, I., additional, Kramm, C. M., additional, Uparkar, U., additional, Geyer, R., additional, Ermoian, R., additional, Ellenbogen, R., additional, Leary, S., additional, Triscott, J., additional, Hu, K., additional, Fotovati, A., additional, Yip, S., additional, Kast, R., additional, Toyota, B., additional, Dunn, S., additional, Hegde, M., additional, Corder, A., additional, Chow, K., additional, Mukherjee, M., additional, Ashoori, A., additional, Brawley, V., additional, Heslop, H., additional, Gottschalk, S., additional, Yvon, E., additional, Ahmed, N., additional, Wong, T.-T., additional, Yang, F.-Y., additional, Lu, M., additional, Liang, H.-F., additional, Wang, H.-E., additional, Liu, R.-S., additional, Teng, M.-C., additional, Yen, C.-C., additional, Agnihotri, S., additional, Ternamian, C., additional, Jones, C., additional, Zadeh, G., additional, Rutka, J., additional, Hawkins, C., additional, Filipek, I., additional, Drogosiewicz, M., additional, Perek-Polnik, M., additional, Swieszkowska, E., additional, Baginska, B. D., additional, Jurkiewicz, E., additional, Perek, D., additional, Kuehn, A., additional, Falkenstein, F., additional, Gnekow, A., additional, Kramm, C., additional, Brooks, M. D., additional, Jackson, E., additional, Mitra, R. D., additional, Rubin, J. B., additional, Liu, X.-Y., additional, Schwartzentruber, J., additional, Fontebasso, A. M., additional, Quang, D.-A. K., additional, Albrecht, S., additional, Dong, Z., additional, Siegel, P., additional, Von Diemling, A., additional, Faury, D., additional, Tabori, U., additional, Majewski, J., additional, Lulla, R., additional, Echevarria, M., additional, Alden, T., additional, DiPatri, A., additional, Tomita, T., additional, Goldman, S., additional, Lin, T., additional, Merchant, T. E., additional, Kocak, M., additional, Panandiker, A. P., additional, Armstrong, G. T., additional, Gielen, G. H., additional, Muehlen, A. z., additional, Hubert, C., additional, Ding, Y., additional, Toledo, C., additional, Paddison, P., additional, Olson, J., additional, Nandhabalan, M., additional, Bjerke, L., additional, Bax, D., additional, Carvalho, D., additional, Bajrami, I., additional, Ashworth, A., additional, Lord, C., additional, Hargrave, D., additional, Reis, R., additional, Workman, P., additional, Little, S., additional, Popov, S., additional, Jury, A., additional, Burford, A., additional, Doey, L., additional, Al-Sarraj, S., additional, Jurgensmeier, J., additional, Chen, L., additional, Kozarewa, I., additional, Baker, S., additional, Perryman, L., additional, Box, G., additional, Raynaud, F., additional, Eccles, S., additional, Viana-Pereira, M., additional, Pereira, M., additional, Forshew, T., additional, Tatevossian, R., additional, Sheer, D., additional, Pimental, J., additional, Pires, M., additional, Sarkar, C., additional, Jha, P., additional, Patrick, I. R. P., additional, Somasundaram, K., additional, Pathak, P., additional, Sharma, M. C., additional, Suri, V., additional, Suri, A., additional, Gerges, N., additional, Haque, T., additional, Nantel, A., additional, Lee, C., additional, Chen, J., additional, Venugopal, C., additional, Singhal, A., additional, Dunham, C., additional, Kerr, J., additional, Verreault, M., additional, Wakimoto, H., additional, Jayanthan, A., additional, Narendran, A., additional, Singh, S., additional, Giraud, G., additional, Holm, S., additional, Gustavsson, B., additional, Kizyma, R., additional, Kizyma, Z., additional, Dvornyak, L., additional, Kotsay, B., additional, Epari, S., additional, Sharma, P., additional, Gurav, M., additional, Gupta, T., additional, Shetty, P., additional, Moiyadi, A., additional, Kane, S., additional, and Jalali, R., additional
Published: 2012
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75. NEUROPSYCHOLOGY

Author: Brinkman, T., primary, Liu, W., additional, Armstrong, G., additional, Gajjar, A., additional, Merchant, T., additional, Kimberg, C., additional, Kun, L., additional, Srivastava, D. K., additional, Gurney, J., additional, Robison, L., additional, Hudson, M., additional, Krull, K., additional, Rubens, J., additional, Lulla, R. R., additional, Lai, J.-S., additional, Fangusaro, J., additional, Wolfe, K., additional, Madan-Swain, A., additional, Reddy, A., additional, Hunter, G., additional, Banos, J., additional, Kana, R., additional, Resch, A., additional, von Hoff, K., additional, von Buren, A. O., additional, Friedrich, C., additional, Treulieb, W., additional, Lindow, C., additional, Kwiecien, R., additional, Ottensmeier, H., additional, Rutkowski, S., additional, Armstrong, C. L., additional, Phillips, P. C., additional, Lustig, R. A., additional, Stamos, C., additional, Li, Y., additional, Belasco, J., additional, Minturn, J. E., additional, Fisher, M. J., additional, Heinks-Maldonado, T., additional, Wingeier, K., additional, Lory, V., additional, Schafer, C., additional, Studer, M., additional, Steinlin, M., additional, Leibundgut, K., additional, de Ruiter, M., additional, Schouten, N., additional, Greidanus, J., additional, Grootenhuis, M., additional, Oosterlaan, J., additional, A, A. L.-V., additional, Grill, J., additional, Puget, S., additional, Sainte-Rose, C., additional, Dufour, C., additional, Kieffer, V., additional, Dellatolas, G., additional, -Shkedi, E. B., additional, Ben Arush, M. W., additional, Kaplinsky, H., additional, Ash, S., additional, Goshen, Y., additional, Yaniv, I., additional, Cohen, I. J., additional, Levy, J. M., additional, Tello, T., additional, Lu, X., additional, Gao, D., additional, Wilkening, G., additional, Donson, A., additional, Foreman, N., additional, Liu, A., additional, Korzeniewska, J., additional, Baginska, B. D., additional, Perek, D., additional, Staccioli, S., additional, Chieffo, D., additional, Petrarca, M., additional, Moxon-Emre, I., additional, Taylor, M., additional, Bouffet, E., additional, Malkin, D., additional, Hawkins, C., additional, Scantlebury, N., additional, Mabbott, D., additional, Cunningham, T., additional, Piscione, J., additional, Igoe, D., additional, Orfus, M., additional, Bartels, U., additional, Laughlin, S., additional, Tabori, U., additional, Hardy, K., additional, Carlson-Green, B., additional, Conklin, H., additional, Dockstader, C., additional, Wang, F., additional, Bostan, S., additional, Liu, F., additional, Zou, P., additional, Conklin, H. M., additional, Mulhern, R. K., additional, Butler, R. W., additional, Ogg, R. J., additional, Diver, T., additional, Manley, P., additional, Kieran, M., additional, Chordas, C., additional, Liptak, C., additional, Delaney, B., additional, Brand, S., additional, and Rey-Casserly, C., additional
Published: 2012
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76. RARE TUMORS

Author: Kiyotani, C., primary, Uno, T., additional, Ogiwara, H., additional, Morota, N., additional, Nakazawa, A., additional, Tsutsumi, Y., additional, Masaki, H., additional, Mori, T., additional, Sanz, J. A. S., additional, Guibelalde, M., additional, Tavera, A., additional, Herandez, I., additional, Ibanez, J., additional, Brell, M., additional, Mas, A., additional, Muller, H. L., additional, Gebhardt, U., additional, Warmuth-Metz, M., additional, Pietsch, T., additional, Sorensen, N., additional, Kortmann, R.-D., additional, Stapleton, S., additional, Gonzalez, I., additional, Steinbrueck, S., additional, Rodriguez, L., additional, Tuite, G., additional, Krzyzankova, M., additional, Mertsch, S., additional, Jeibmann, A., additional, Kordes, U., additional, Wolff, J., additional, Paulus, W., additional, Hasselblatt, M., additional, Nonaka, Y., additional, Hara, S., additional, Fukazawa, S., additional, Shimizu, K., additional, Ben-Arush, M., additional, Postovsky, S., additional, Toledano, H., additional, Peretz-Nahum, M., additional, Fujimura, J., additional, Sakaguchi, S., additional, Kondo, A., additional, Saito, Y., additional, Shimoji, K., additional, Ohara, Y., additional, Arakawa, A., additional, Saito, M., additional, Shimizu, T., additional, Benesch, M., additional, von Bueren, A. O., additional, Dantonello, T., additional, von Hoff, K., additional, Leuschner, I., additional, Claviez, A., additional, Bierbach, U., additional, Kropshofer, G., additional, Korinthenberg, R., additional, Graf, N., additional, Suttorp, M., additional, Kortmann, R. D., additional, Friedrich, C., additional, Klingebiel, T., additional, Koscielniak, E., additional, Rutkowski, S., additional, Mesa, M., additional, Sanchez, M., additional, Mejia, J., additional, Pena, G., additional, Dussan, R., additional, Cabeza, M., additional, Storino, A., additional, Dincer, F., additional, Roffidal, T., additional, Powell, M., additional, Berrak, S., additional, Wolff, J. E., additional, Fouyssac, F., additional, Delaunay, C., additional, Vignaud, J.-M., additional, Schmitt, E., additional, Klein, O., additional, Mansuy, L., additional, Chastagner, P., additional, Cruz, O., additional, Guillen, A., additional, Garcia, G., additional, Alamar, M., additional, Candela, S., additional, Roussos, I., additional, Garzon, M., additional, Sunol, M., additional, Muchart, J., additional, Rebollo, M., additional, Mora, J., additional, Diez, B., additional, Muggeri, A., additional, Arakaki, N., additional, Meli, F., additional, Sevlever, G., additional, Tsitouras, V., additional, Pettorini, B., additional, Fellows, G., additional, Blair, J., additional, Didi, M., additional, Daousi, C., additional, Steele, C., additional, Javadpour, M., additional, Sinha, A., additional, Hishii, M., additional, Ishii, H., additional, Miyajima, M., additional, Arai, H., additional, Dvir, R., additional, Sayar, D., additional, Levin, D., additional, Ben-Sirah, L., additional, Constantini, S., additional, Elhasid, R., additional, Gertsch, E., additional, Foreman, N., additional, Valera, E. T., additional, Brassesco, M. S., additional, Machado, H. R., additional, Oliveira, R. S., additional, Santos, A. C., additional, Terra, V. C., additional, Barros, M. V., additional, Scrideli, C. A., additional, Tone, L. G., additional, Merino, D., additional, Pienkowska, M., additional, Shlien, A., additional, Tabori, U., additional, Gilbertson, R., additional, Malkin, D., additional, Jeeva, I., additional, Chang, B., additional, Long, V., additional, Picton, S., additional, Burton, D., additional, Clark, S., additional, Kwok, C., additional, Mokete, B., additional, Rafiq, O., additional, Simmons, I., additional, Shing, M. M. K., additional, Li, C. K., additional, Chan, G. C. F., additional, Ha, S. Y., additional, Yuen, H. L., additional, Luk, C. W., additional, Ling, S. C., additional, Li, R. C. H., additional, Yoon, J. H., additional, Park, H. J., additional, Shin, H. J., additional, Park, B.-K., additional, Kim, J.-Y., additional, Jung, H. L., additional, Ra, Y. S., additional, Ghim, T. T., additional, Hartung, S., additional, Garami, M., additional, Traunecker, H., additional, Thall, P., additional, Mahajan, A., additional, Sumerauer, D., additional, Grillner, P., additional, Orrego, A., additional, Mosskin, M., additional, Gustavsson, B., additional, Holm, S., additional, Peters, N., additional, Rogers, M., additional, Chowdry, S., additional, Selman, W., additional, Mitchell, A., additional, Bangert, B., additional, Ahuja, S., additional, Laschinger, K., additional, Gold, D., additional, Stearns, D., additional, Wright, K., additional, Gupta, K., additional, Klimo, P., additional, Ellison, D., additional, Keating, G., additional, Eckel, L., additional, Giannini, C., additional, Wetjen, N., additional, Patton, A., additional, Zaky, W., additional, McComb, G., additional, Finlay, J., additional, Grimm, J., additional, Wong, K., additional, Dhall, G., additional, Gilles, F., additional, Ormandy, D., additional, Alston, R., additional, Estlin, E., additional, Gattamaneni, R., additional, Birch, J., additional, Kamaly-Asl, I., additional, Hemenway, M., additional, Rush, S., additional, Reginald, Y. A., additional, Nicolin, G., additional, Bartel, U., additional, Buncic, J. R., additional, Aguilera, D., additional, Flamini, R., additional, Mazewski, C., additional, Schniederjan, M., additional, Hayes, L., additional, Boydston, W., additional, MacDonald, T., additional, Fleming, A., additional, Jabado, N., additional, Saint-Martin, C., additional, Albrecht, S., additional, Ramsay, D. A., additional, Farmer, J. P., additional, Bendel, A., additional, Hansen, M., additional, Dugan, S., additional, and Mendelsohn, N., additional
Published: 2012
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77. EPIDEMIOLOGY

Author: Khatua, S., primary, Brown, R., additional, Pearlman, M., additional, Vats, T., additional, Satge, D., additional, Stiller, C., additional, Rutkowski, S., additional, von Bueren, A. O., additional, Lacour, B., additional, Sommelet, D., additional, Nishi, M., additional, Massimino, M., additional, Garre, M.-L., additional, Moreno, F., additional, Hasle, H., additional, Jakab, Z., additional, Greenberg, M., additional, von der Weid, N., additional, Kuehni, C., additional, Zurriaga, O., additional, Vicente, M.-L., additional, Peris-Bonet, R., additional, Benesch, M., additional, Vekemans, M., additional, Sullivan, S., additional, Rickert, C., additional, Fisher, P. G., additional, Von Behren, J., additional, Nelson, D. O., additional, Reynolds, P., additional, Fukuoka, K., additional, Yanagisawa, T., additional, Suzuki, T., additional, Koga, T., additional, Wakiya, K., additional, Adachi, J.-i., additional, Mishima, K., additional, Fujimaki, T., additional, Matsutani, M., additional, Nishikawa, R., additional, Gidding, C., additional, Schieving, J., additional, Wesseling, P., additional, Ligtenberg, M., additional, Hoogerbrugge, N., additional, Jongmans, M., additional, Crosier, S., additional, Nicholson, S. L., additional, Robson, K., additional, Jacques, T., additional, Wharton, S., additional, Bown, N., additional, Michalski, A., additional, Pizer, B., additional, Clifford, S., additional, Sanden, E., additional, Visse, E., additional, Siesjo, P., additional, Darabi, A., additional, Nousome, D., additional, Lupo, P. J., additional, Scheurer, M. E., additional, Nulman, I., additional, Barrera, M., additional, Maxwell, C., additional, Koren, G., additional, Gorelyshev, S., additional, Matuev, K., additional, Lubnin, A., additional, Laskov, M., additional, Lemeneva, N., additional, Mazerkina, N., additional, Khuhlaeva, E., additional, Muller, K., additional, Bruns, F., additional, Pietsch, T., additional, Kortmann, R.-D., additional, Krishnatry, R., additional, Shirsat, N., additional, Kunder, R., additional, Epari, S., additional, Gupta, T., additional, Kurkure, P., additional, Vora, T., additional, Arora, B., additional, Moiyadi, A., additional, Jalali, R., additional, Swieszkowska, E., additional, Dembowska-Baginska, B., additional, Drogosiewicz, M., additional, Filipek, I., additional, Perek-Polnik, M., additional, Grajkowska, W., additional, Perek, D., additional, Johnston, D., additional, Cyr, J., additional, Strother, D., additional, Lafay-Cousin, L., additional, Fryer, C., additional, Scheinemann, K., additional, Carret, A.-S., additional, Fleming, A., additional, Larouche, V., additional, Bouffet, E., additional, Friedrich, C., additional, Gnekow, A. K., additional, Fleischhack, G., additional, Kramm, C. M., additional, Fruehwald, M. C., additional, Muller, H. L., additional, Calaminus, G., additional, Kordes, U., additional, Faldum, A., additional, Warmuth-Metz, M., additional, Kortmann, R. D., additional, Jung, I., additional, Kaatsch, P., additional, Caretti, V., additional, Bugiani, M., additional, Boor, I., additional, Schellen, P., additional, Vandertop, W. P., additional, Noske, D. P., additional, Kaspers, G., additional, Wurdinger, T., additional, Robinson, G., additional, Chingtagumpala, M., additional, Adesina, A., additional, Dalton, J., additional, Santi, M., additional, Sievert, A., additional, Wright, K., additional, Armstrong, G., additional, Boue, D., additional, Olshefski, R., additional, Scott, S., additional, Huang, A., additional, Cohn, R., additional, Gururangan, S., additional, Bowers, D., additional, Gilbertson, R., additional, Gajjar, A., additional, Ellison, D., additional, Chick, E., additional, Donson, A., additional, Owens, E., additional, Smith, A. A., additional, Madden, J. R., additional, Foreman, N. K., additional, Bakry, D., additional, Aronson, M., additional, Durno, C., additional, Hala, R., additional, Farah, R., additional, Amayiri, N., additional, Alharbi, Q., additional, Shamvil, A., additional, Ben-Shachar, S., additional, Constantini, S., additional, Rina, D., additional, Ellise, J., additional, Keiles, S., additional, Pollet, A., additional, Qaddoumi, I., additional, Gallinger, S., additional, Malkin, D., additional, Hawkins, C., additional, Tabori, U., additional, Trivedi, M., additional, Goodden, J., additional, Chumas, P., additional, Tyagi, A., additional, O'kane, R., additional, O'Kane, R., additional, Crimmins, D., additional, Picton, S., additional, and Elliott, M., additional
Published: 2012
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78. CLINICAL TRIALS

Author: Stapleton, S., primary, Flanary, J., additional, Hamblin, F., additional, Steinbrueck, S., additional, Rodriguez, L., additional, Tuite, G., additional, Carey, C., additional, Storrs, B., additional, Lavey, R., additional, Fangusaro, J., additional, Jakacki, R., additional, Kaste, S., additional, Goldman, S., additional, Pollack, I., additional, Boyett, J., additional, Kun, L., additional, Gururangan, S., additional, Dombi, E., additional, Steinberg, S., additional, Kieran, M., additional, Ullrich, N., additional, Widemann, B., additional, Lulla, R., additional, Reinholdt, N., additional, Newmark, M., additional, Urban, M., additional, Chi, S., additional, Manley, P., additional, Robison, N., additional, Kroon, H.-A., additional, Stancokova, T., additional, Husakova, K., additional, Deak, L., additional, Onar-Thomas, A., additional, Packer, R., additional, Friedman, H., additional, Poussaint, T. Y., additional, Gudrun, F., additional, Tippelt, S., additional, Zimmermann, M., additional, Rutkowski, S., additional, Warmuth-Metz, M., additional, Pietsch, T., additional, Faldum, A., additional, Bode, U., additional, Slavc, I., additional, Peyrl, A., additional, Chocholous, M., additional, Azizi, A., additional, Czech, T., additional, Dieckmann, K., additional, Haberler, C., additional, Macy, M., additional, Cohen, K., additional, MacDonald, T., additional, Smith, A., additional, Etzl, M., additional, Naranderan, A., additional, Gore, L., additional, DiRenzo, J., additional, Trippett, T., additional, Foreman, N., additional, Dunkel, I., additional, Fisher, M. J., additional, Meyer, J., additional, Roberts, T., additional, Belasco, J. B., additional, Phillips, P. C., additional, Lustig, R., additional, Cahill, A. M., additional, Laureano, A., additional, Huls, H., additional, Somanchi, S., additional, Denman, C., additional, Liadi, I., additional, Khatua, S., additional, Varadarajan, N., additional, Champlin, R., additional, Lee, D., additional, Cooper, L., additional, Silla, L., additional, Gopalakrishnan, V., additional, Legault, G., additional, Hagiwara, M., additional, Ballas, M., additional, Brown, K., additional, Vega, E., additional, Nusbaum, A., additional, Bloom, M., additional, Hochman, T., additional, Goldberg, J., additional, Golfinos, J., additional, Roland, J. T., additional, Allen, J., additional, Karajannis, M., additional, Bergner, A., additional, Giovannini, M., additional, Welling, D. B., additional, Niparko, J., additional, Slattery, W., additional, Blakeley, J., additional, Owens, C., additional, Sung, L., additional, Lowis, S., additional, Gentet, J.-C., additional, Bouffet, E., additional, Henry, J., additional, Bala, A., additional, Freeman, S., additional, King, A., additional, Rutherford, S., additional, Mills, S., additional, Huson, S., additional, McBain, C., additional, Lloyd, S., additional, Evans, G., additional, McCabe, M., additional, Lee, Y., additional, Bartels, U., additional, Tabori, U., additional, Jansen, L., additional, Mabbott, D., additional, Huang, A., additional, Aguilera, D., additional, Mazewski, C., additional, McNall, R., additional, Hayes, L., additional, Liu, Y., additional, Castellino, R., additional, Cole, D., additional, Lester-McCully, C., additional, Warren, K., additional, Campigotto, F., additional, Turner, C., additional, Zimmerman, M. A., additional, Chordas, C., additional, Rubin, J., additional, Isakoff, M., additional, Pan, W., additional, Khatib, Z., additional, Comito, M., additional, Bendel, A., additional, Pietrantonio, J., additional, Kondrat, L., additional, Hubbs, S., additional, Neuberg, D., additional, Wetmore, C., additional, Broniscer, A., additional, Wright, K., additional, Armstrong, G., additional, Baker, J., additional, Pai-Panandiker, A., additional, Patay, Z., additional, Ramachandran, A., additional, Turner, D., additional, Gajjar, A., additional, and Stewart, C., additional
Published: 2012
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79. Visual outcomes in children with neurofibromatosis type 1-associated optic pathway glioma following chemotherapy: a multicenter retrospective analysis

Author: Fisher, M. J., primary, Loguidice, M., additional, Gutmann, D. H., additional, Listernick, R., additional, Ferner, R. E., additional, Ullrich, N. J., additional, Packer, R. J., additional, Tabori, U., additional, Hoffman, R. O., additional, Ardern-Holmes, S. L., additional, Hummel, T. R., additional, Hargrave, D. R., additional, Bouffet, E., additional, Charrow, J., additional, Bilaniuk, L. T., additional, Balcer, L. J., additional, and Liu, G. T., additional
Published: 2012
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80. Early aging in adult survivors of childhood medulloblastoma: long-term neurocognitive, functional, and physical outcomes

Author: Edelstein, K., primary, Spiegler, B. J., additional, Fung, S., additional, Panzarella, T., additional, Mabbott, D. J., additional, Jewitt, N., additional, D'Agostino, N. M., additional, Mason, W. P., additional, Bouffet, E., additional, Tabori, U., additional, Laperriere, N., additional, and Hodgson, D. C., additional
Published: 2011
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81. Neuro-cognitive

Author: O'Neil, S. H., primary, Azoff, J., additional, Buranahirun, C., additional, Dhall, G., additional, Panigrahy, A., additional, Borchert, M., additional, Khatua, S., additional, Ji, L., additional, Sposto, R., additional, Finlay, J., additional, Gong, X., additional, Schwartz, P., additional, Linskey, M., additional, Bota, D. A., additional, Wefel, J. S., additional, Patwardhan, S. Y., additional, Strange, C., additional, Emily, F., additional, Celine, A., additional, Penelope, K., additional, Anne-Sophie, C., additional, Rolando, D. M., additional, Michael, P., additional, Correa, D. D., additional, Shi, W., additional, Abrey, L., additional, DeAngelis, L., additional, Thaler, H., additional, Habets, E. J., additional, Walchenbach, R., additional, Kloet, A., additional, Zwinkels, H., additional, Klein, M., additional, Vecht, C. J., additional, Taphoorn, M. J., additional, Ambachtsheer, N., additional, van Nieuwenhuizen, D., additional, Heimans, J. J., additional, Reijneveld, J. C., additional, Peerdeman, S. M., additional, Lagemaat, C., additional, Peters, K. B., additional, Reardon, D. A., additional, Vredenburgh, J. J., additional, Desjardins, A., additional, Friedman, H. S., additional, Driever, P. H., additional, Koustenis, E., additional, Henze, G., additional, De Sonneville, L., additional, Rueckriegel, S. M., additional, Mok, K., additional, Klein, D., additional, Del Maestro, R., additional, Petrecca, K., additional, Olivier, A., additional, Schanker, B. D., additional, Curry, W. T., additional, Edelstein, K., additional, Spiegler, B. J., additional, Fung, S., additional, Panzarella, T., additional, Hodgson, D. C., additional, Mabbott, D. J., additional, Laperriere, N., additional, Tabori, U., additional, Bouffet, E., additional, and Mason, W. P., additional
Published: 2010
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82. Impact of early detection strategies on cancer mortality in germlineTP53 mutation carriers in Li-Fraumeni syndrome.

Author: Villani, A., primary, Tabori, U., additional, Schiffman, J. D., additional, Shlien, A., additional, Druker, H., additional, Novokmet, A., additional, Finlay, J. L., additional, and Malkin, D., additional
Published: 2010
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83. Long-term neurocognitive outcomes in adult survivors of childhood medulloblastoma.

Author: Edelstein, K., primary, Spiegler, B. J., additional, Fung, S., additional, Panzarella, T., additional, Hodgson, D. C., additional, Mabbott, D. J., additional, Laperriere, N., additional, Tabori, U., additional, Bouffet, E., additional, and Mason, W. P., additional
Published: 2010
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84. Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumours

Author: Jacob, K, primary, Albrecht, S, additional, Sollier, C, additional, Faury, D, additional, Sader, E, additional, Montpetit, A, additional, Serre, D, additional, Hauser, P, additional, Garami, M, additional, Bognar, L, additional, Hanzely, Z, additional, Montes, J L, additional, Atkinson, J, additional, Farmer, J-P, additional, Bouffet, E, additional, Hawkins, C, additional, Tabori, U, additional, and Jabado, N, additional
Published: 2009
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85. Telomere maintenance and dysfunction predict recurrence in paediatric ependymoma

Author: Tabori, U, primary, Wong, V, additional, Ma, J, additional, Shago, M, additional, Alon, N, additional, Rutka, J, additional, Bouffet, E, additional, Bartels, U, additional, Malkin, D, additional, and Hawkins, C, additional
Published: 2008
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86. CONTRIBUTION OF DNA COPY-NUMBER VARIATION (CNV) TO CANCER SUSCEPTIBILITY AND LARGE-SCALE GENOME ALTERATIONS IN OSTEOSARCOMA (OS)

Author: Pasic, I, primary, Shlien, A, additional, Novokmet, A, additional, Zhang, C, additional, Tabori, U, additional, Pinto, D, additional, Scherer, S W, additional, and Malkin, D, additional
Published: 2008
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87. Feasibility and efficacy of second-line chemotherapy at recurrence for pediatric low-grade gliomas: A comparative population-based study

Author: Scheinemann, K., primary, Bartels, U., additional, Huang, A., additional, Hawkins, C., additional, Bouffet, E., additional, and Tabori, U., additional
Published: 2008
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88. Telomere maintenance predicts progression and survival in pediatric intracranial ependymoma

Author: Tabori, U., primary, Bouffet, E., additional, Bartels, U., additional, Malkin, D., additional, and Hawkins, C., additional
Published: 2006
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89. Evolution of a T-B- SCID into an Omenn syndrome phenotype following parainfluenza 3 virus infection

Author: DALAL, I, primary, TABORI, U, additional, BIELORAI, B, additional, GOLAN, H, additional, ROSENTHAL, E, additional, AMARIGLIO, N, additional, RECHAVI, G, additional, and TOREN, A, additional
Published: 2005
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90. l-Thyroxine prevents the bone-conserving effect of HRT in postmenopausal women with subclinical hypothyroidism

Author: Pines, A., primary, Dotan, I., additional, Tabori, U., additional, Villa, Y., additional, Mijatovic, V., additional, Levo, Y., additional, and Ayalon, D., additional
Published: 1999
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91. P-59. Thyroxine Prevents the Bone Conserving Effect of Hormone Replacement Therapy in Post-menopausal Women with Subclinical Hypothyroidism

Author: Pines, A., primary, Zahavi, Z., additional, Dotan, I., additional, Tabori, U., additional, and Ayalon, D., additional
Published: 1998
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92. Phase II Study of Weekly Vinblastine in Recurrent or Refractory Pediatric Low-Grade Glioma.

Author: Bouffet E, Jakacki R, Goldman S, Hargrave D, Hawkins C, Shroff M, Hukin J, Bartels U, Foreman N, Kellie S, Hilden J, Etzl M, Wilson B, Stephens D, Tabori U, and Baruchel S
Published: 2012

93. Short Report Detection of RAG mutations and prenatal diagnosis in families presenting with either T–B– severe combined immunodeficiency or Omenn's syndrome.

Author: Tabori, U., Mark, Z., Amariglio, N., Etzioni, A., Golan, H., Biloray, B., Toren, A., Rechavi, G., and Dalal, I.
Subjects: *IMMUNOLOGICAL deficiency syndromes, *GENETIC mutation, *POLYMERASE chain reaction, *GENES, *PRENATAL diagnosis, *FAMILIAL diseases
Abstract: Tabori U, Mark Z, Amariglio N, Etzioni A, Golan H, Biloray B, Toren A, Rechavi G, Dalal I. Detection of RAG mutations and prenatal diagnosis in families presenting with either T–B– severe combined immunodeficiency or Omenn's syndrome. It has been recently shown that mutations in both of the recombination activating genes RAG1 and RAG2 are involved in each of the two different types of severe combined immunodeficiency (SCID) syndromes: T–B– SCID and Omenn's syndrome (OS). The objective of the study was to search for novel mutations in the RAG genes and to offer prenatal diagnosis for families that have been identified as at risk of T–B– SCID or OS. Mutation analyses of polymerase chain reaction products of RAG1/ RAG2 genes were performed in 14 cases (T–B– SCID = 6 and OS = 8). Consanguinity was reported in seven (50%) families. Four missense mutations in the RAG2 gene in six of eight OS patients and in four of six T–B– SCID patients were detected. The C1845T transition leading to a Tre215Ile substitution is a novel mutation. All but one of the patients were homozygous for the detected mutations, possibly reflecting the consanguinity in these families and the relative rarity of the disease-causing mutations. In addition, three putative polymorphic sites were found. Prenatal diagnosis was offered to seven families, but three of them declined genetic counseling for religious reasons. In the remaining families, four pregnancies were successfully completed, and in one case, the family chose to have an abortion because of a homozygous mutation. Mutations in RAG1/ RAG2 genes were detected in only some of the T–B– SCID or OS patients, and the molecular basis for the remaining cases has yet to be elucidated. Important factors such as religious beliefs need to be considered when offering prenatal diagnosis to certain families. [ABSTRACT FROM AUTHOR]
Published: 2004
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94. Repeat computed tomographic scan within 24-48 hours of admission in children with moderate and severe head trauma.

Author: Tabori, U, Kornecki, A, Sofer, S, Constantini, S, Paret, G, Beck, R, and Sivan, Y
Published: 2000

95. Sustained complete response of recurrent glioblastoma to combined checkpoint inhibition in a young patient with constitutional mismatch repair deficiency.

Author: Larouche, Valerie, Atkinson, J., Albrecht, S., Laframboise, R., Jabado, N., Tabori, U., Bouffet, E., and international bMMRD consortium
Published: 2018
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96. BI-21BRAF MUTATION AND CDKN2A DELETIONS DEFINE A CLINICALLY DISTINCT SUBGROUP OF CHILDHOOD SECONDARY HIGH GRADE GLIOMA

Author: Mistry M, Zhukova N, Merico D, Rakopoulos P, Krishnatry R, Shago M, Stavropoulos J, Ray P, Mangerel J, Marc Remke, Buczkowicz P, Ramaswamy V, Rutka J, Dirks P, Taylor M, Bouffet E, Malkin D, Huang A, Hawkins C, and Tabori U
Subjects: Abstracts, Cancer Research, Oncology, Neurology (clinical)
Abstract: PURPOSE: Pediatric secondary high grade glioma (sHGG), which result from malignant transformation of low grade glioma (PLGG), are a poorly understood group of tumors with devastating outcomes. PATIENTS AND METHODS: We performed a population-based study combined with long-term follow-up of PLGG that transformed to sHGG. Exonic-sequencing and copy number alterations were investigated on a discovery cohort, followed by detailed genetic analysis of all tumors. Clinical and outcome data analysis of a genetically distinct subgroup was performed. RESULTS: sHGG were observed in 28/888 (3.2%) patients treated in Southern Ontario for PLGG with a median latency of 2.74 years (range, 0.18-20.3 years). sHGG were characterized by a high somatic mutation load (23 per genome). Alterations in chromatin modifying genes and major telomere maintenance pathways were observed in 57% and 54% of sHGG respectively. However, specific mutations in IDH1, H3F3A G34 and ATRX were extremely rare. The most recurrent somatic alterations were the oncogenic BRAF V600E mutation and deletion of the tumor suppressor gene CDKN2A, observed in 39% and 57% of sHGG respectively. Importantly, all BRAF V600E and 80% of CDKN2A alterations could be traced to the patient-matched PLGG counterparts. These early alterations were rarely observed in non-transformed PLGG (p < 0.0001) and primary childhood high grade glioma (p = 0.0023). The BRAF mutant sHGG subgroup was characterized by longer latency periods to transformation than non-BRAF mutant sHGG (median 6.59 versus 1.62 years; p < 0.0001). Furthermore, 5-year overall survival of children with BRAF mutant and wild-type PLGG that transformed were 75% ± 15% and 29% ± 12% respectively (p = 0.024). CONCLUSION: BRAF V600E mutations and CDKN2A deletions constitute a clinically distinct subtype of sHGG. The prolonged course to transformation provides a window of opportunity for aggressive surgical interventions, targeted therapy against oncogenic BRAF, and extended surveillance to potentially mitigate the devastating transformation event.

97. LGG-16. PREDICTORS OF OUTCOME IN BRAF-V600E PEDIATRIC GLIOMAS TREATED WITH BRAF INHIBITORS: A REPORT FROM THE PLGG TASKFORCE

Author: Nobre L, Zapotocky M, Ryall S, Ag, Stucklin, Bennett J, Baroni L, Sumerauer D, Zamecnik J, Krskova L, Misove A, Pavelka Z, Sterba J, Cruz O, and Tabori U

98. LGG-19. SPINAL LOW-GRADE GLIOMAS IN CANADIAN CHILDREN: A MULTI-CENTRE RETROSPECTIVE REVIEW

Author: Coltin H, Benipal S, Shahrad Rod Rassekh, Nobre L, Bennett J, Tabori U, Wilson B, Mehta V, Beaudoin W, Zelcer S, Cheng S, Hukin J, Hawkins C, Bouffet E, and Johnston D

99. RARE-17. SURVIVAL BENEFIT FOR INDIVIDUALS WITH CONSTITUTIONAL MISMATCH REPAIR DEFICIENCY SYNDROME AND BRAIN TUMORS WHO UNDERGO SURVEILLANCE PROTOCOL. A REPORT FROM THE INTERNATIONAL REPLICATION REPAIR CONSORTIUM

Author: Ercan A, Durno C, Bianchi V, Edwards M, Aronson M, Bouffet E, Al-Battashi A, Alharbi M, Basel D, Bedgood R, Bendel A, Blumenthal D, Bornhorst M, and Tabori U

100. LGG-55. OUTCOME OF BRAF V600E PEDIATRIC GLIOMAS TREATED WITH TARGETED BRAF INHIBITION

Author: Nobre L, Zapotocky M, Ramaswamy V, Ryall S, Bennet J, Alderete D, Guill J, Baroni L, Bartels U, Bavle A, Bornhorst M, Boue’ D, Canete A, and Tabori U

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