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This study conducted investigations aimed at clarifying the differences in environmental control behaviour, thermal/air environments and pupils’ thermal sensations before and after installation of cooling systems. It also developed guidelines for operating the equipment. Measurements of temperatures and CO2 concentration, visual inspection of environmental control behaviour and questionnaires about thermal sensation were performed in classrooms of one elementary school in Tokyo. Results showed that in classrooms without cooling systems, fans were operated and windows and doors were opened fully when room temperatures were 28oC or higher. In classrooms equipped with cooling systems, cases of operating both cooling systems and fans were numerous. Also, the CO2 concentration often exceeded the level of 1500 ppm with the opening ratio of windows/doors as low as 10%. When the required opened areas of windows/doors are maintained, CO2 concentrations levels were kept below 1500 ppm. The guidelines of ope...

Ultrafast dynamics of amplitude and phase in a silicon wire waveguide are measured by a heterodyne pump probe technique at a wavelength of 1.55 μm. We determined the two-photon absorption coefficient and nonlinear refractive index to be βTPA = 0.43 cm/GW and n2 = 2.0 × 1018 m2/W, respectively. A theoretical analysis indicates that the index change due to the carrier plasma effect is linear to the carrier density when it is low as in the case of optical injection.

In this paper, we construct an eigenform of weight one by using meromorphic η-quotients. It is the modular form associated to an irreducible representation $\rho : {\rm Gal}(L/\mathbb {Q})\rightarrow {\rm GL}_{2}(\mathbb {C})$ with $L=\mathbb {Q}(\sqrt{-3},\sqrt[3]{3})$ .

症例は47歳，女性．検診の上部消化管内視鏡検査にて胃体中部大弯に40mm大，中心陥凹を伴うcushion sign陰性の粘膜下腫瘍を認め，1年前より増大傾向にあったため当院へ紹介となった．超音波内視鏡下穿刺吸引生検にて間葉系腫瘍を認め，免疫組織染色ではS-100蛋白陽性，α-SMA陰性，c-kit陰性，CD34陰性であったことから胃神経鞘腫と術前診断し，腹腔鏡下胃局所切除術を施行した．腫瘍径は40×40mm大，紡錘形細胞が束状に増殖し，S-100蛋白陽性，Desmin陰性，α-SMA陰性，c-kit陰性，CD34陰性であった．異型性は軽度で核分裂像はほとんど認められず，良性胃神経鞘腫と診断した．術後経過は良好で，7カ月間の経過観察では現在のところ再発を認めていない．胃神経鞘腫に対する明確な治療方針は示されていないが，良性であることが多く悪性例でもリンパ節転移が少ないことから，手術適応例については低侵襲な腹腔鏡手術が有用であると思われる．

This study is aiming at evaluating resultant distributions of thermal and airflow environment in a room ventilated with various air supply openings, and comparing input energy required for heating with floor heating systems or with convective heating systems. Experiments were conducted for different PMV levels. The results are summarized as follows: 1) Conditions of the warm jet issuing from convective heating system significantly affect the vertical and horizontal temperature differences, airflow structures, DR and PMV values. 2) Thermal and airflow environment is maintained uniform, and DR values in most places are kept under 15% during heating with floor heating system. 3) Attachment points and diffusion paths of the ventilated air are markedly different depending on the air supply openings. 4) Input energy required for heating with floor heating system is roughly 20% smaller than that of convective heating system if evaluated with secondary energy directly concerned with room heating.

症例は78歳の女性で，9年前に胃癌に対する胃全摘術（脾摘併施・前結腸性Roux-en Y再建）の既往がある．深夜からの腹痛・悪心を主訴に当科を受診し，造影CTにて胃全摘時の空腸空腸端側吻合部（Y吻合部）に関連した内ヘルニアによる絞扼性イレウス・急性輸入脚閉塞症と診断した．緊急開腹すると，胃全摘時の再建挙上空腸脚（Y脚）が過長で，これが脾摘後の左横隔膜に癒着して腸管係蹄を形成しており，これにY吻合部以下の小腸係蹄が巻付いて結節を形成し，Y吻合部がこれに巻込まれて輸入脚閉塞を来していた．診断は腸管結節形成症であった．結節を解除すると，鬱血していたY脚と小腸の血行は改善したが，Treitz靭帯直後の輸入脚後壁に穿孔を認めた．穿孔部を縫合閉鎖し，Y脚の横隔膜への癒着を剥離して係蹄を直線化し，チューブ十二指腸瘻を造設した．術後，腸瘻部のminor leakageを併発したが，27日目に軽快退院した．

The urban surface has been covered with concrete buildings and asphalt pavements. They have large thermal capacity and absorb solar heat so that heat island phenomena may appear in the urban area. Therefore increase of solar reflection at the urban surfaces is one of countermeasures of heat island, because high reflective roof (hereafter cool roof) and high reflective pavement (hereafter cool pavement) can cool the urban surface and reduce the heat flux from them to urban air. The measured data in the previous paper shows that cool pavement can reduce sensible heat flux from pavement to urban air. On the other hand, reflected solar radiation from pavement may raise surface temperature of human body and cause discomfort of pedestrians. This paper shows that measured temperature of human body models and calculated SET* on cool pavement are higher than those on ordinary pavement according to the amount of reflective heat. In this paper CFD simulations are conducted to study human body temperature when only pavement for vehicles is coated by the high reflective paint and sidewalk for pedestrians is not high reflective.

症例は76歳の女性で，腹痛・嘔吐を主訴に平成20年1月下旬，当院を受診した．CTにて右閉鎖孔ヘルニアの診断，術前イレウス管挿入にて腸回転異常の疑いとなり，緊急手術を施行．開腹所見では，時計回りに360度回転した小腸とRichter型の回腸陥入ヘルニアを認めた．消化管穿孔および小腸壊死は認めず，閉鎖孔閉鎖および予防的虫垂切除を施行した．術後経過は良好で，術後9日目に軽快退院となった．閉鎖孔ヘルニアと腸回転異常による腸軸捻転を同時に発症したまれな1例を経験したので文献的考察を交えて報告する．

In this research, the wake turbulence from actual passenger airplanes taking off from Sendai airport was measured with Electronic Navigation Research Institute's Doppler laser radar (lidar). First, the influence of the surrounding wind on the behavior of wake vortices was investigated. The wake vortices in the crosswind case disappear more quickly from the runway than those of the low surrounding wind and head wind cases. In addition, the wake vortices in the case of large crosswind move faster than those in small crosswind. Next, the correction factor was estimated by using the pseudo lidar measurements based on Computational Fluid Dynamics (CFD). The corrected data for weak surrounding wind case agreed with the existing wake vortex model.

Numerical simulation of wake turbulence was performed by integrating the lidar measurements using four-dimensional variational method. A bogus vortex technique was adopted to ensure the existence of wake vortices in the flow field. The validation of the method was performed by an idealized test case using virtual lidar measurement which was produced by the reference simulation of a vortex pair. The results of the validation showed the convergence of a vortex parameter such as a circulation to the parameter of reference simulation case. It was also confirmed that the velocity distribution on a measurement plane agreed with reference one.

S状結腸sm癌術後６年目の骨盤腔内巨大リンパ節転移に対する１切除例を経験したので報告する．症例は69歳の男性で2001年に早期S状結腸癌に対しEMRを施行．病理検査結果で深達度sm，margin unclearであったため追加切除目的に腹腔鏡下S状結腸切除術（D1）施行．６年後の2007年10月，突然の高熱を認め当院受診し緊急入院となった．CT・MRIで骨盤腔内に10×10cmの巨大腫瘍を認め，大腸内視鏡にてS状結腸粘膜面のびらんおよび注腸検査にてS状結腸の圧排像を認めた．エコー下針生検にてmoderately differentiated adenocarcinomaの診断となり，腫瘍を含めたS状結腸切除術（Hartmann型）施行．病理検査の結果はS状結腸癌のNo.241に相当するリンパ節転移であった．術前に高値を認めた腫瘍マーカーは術後正常値となり，現在外来にて化学療法中である．sm癌根治術後の単発リンパ節再発は極めて稀であるが，分化度や脈管／リンパ管侵襲によりリンパ節転移高危険群と判断される症例には術後の定期的な再発巣検索のためのサーベイランスの必要性が示唆された．

The mean air temperature in urban areas has risen due to a change of urban structure in a long term. High reflective paints can reduce a cooling load of buildings and may also improve the thermal environment in urban areas. In this paper, field measurements were carried out on pavement where two areas of surface were coated with high reflective paint and ordinary material. Then, the heat flux on the urban surface was calculated on the basis of heat budget equation with the measured data, and the result was compared with the artificial heat release from buildings etc. in 23 wards of Tokyo. The results of this paper show that high reflective paint is effective to resolve heat island problem.

The mean air temperature in urban areas has risen due to a change of urban structure in a long term. High reflective paints can reduce a cooling load of buildings and can also improve the thermal environment in urban areas. In this paper, field measurements were carried out in a building where two areas of rooftop were finished with high reflective paint and ordinary paint. Then, the heat flux on the urban surface was calculated on the basis of heat budget equation with measured data, and the result was compared with the artificial heat release from buildings in 23 wards of Tokyo. The results of this paper show that high reflective paint is effective to resolve heat island problem. On the other hand, short wave radiation reflected at high reflective roofs may increase cooling load of neighbor buildings. In this paper, the coupled simulations of radiation and convection around buildings were conducted to estimate the influence of solar reflection at roofs on surrounding building walls. The results show that short wave radiation from high reflective roofs to neighbor building walls is much smaller than direct radiation from sun and sky to walls.

A 76-year-old man underwent surgery for sigmoid colon cancer. The pathological finding was stage Ⅱ with a high-risk of recurrence (SI [bladder], l y0, v2, pN0, H0, P0, M0). He was treated with TS-1 as adjuvant chemotherapy. After the 1 course of chemotherapy, his platelet count was 4,000/mL. The high index of platelet associated IgG (PA-IgG) and bone marrow examination suggested that thrombocytopenia was caused by idiopathic thrombocytopenic purpura. The platelet count improved by prednisolone administration and Helicobacter pylori eradication treatment. After 6 months with no administration of adjuvant chemotherapy, the colon cancer recurred locally, and we performed a Hartmann's operation.

A 71-year-old man was diagnosed with a gastric tumor approximately 50mm in diameter on computed tomography (CT). In January 2000, he underwent a proximal gastrectomy. Pathological examination showed 5 mitoses per 50 high-power fields, while immunohistochemical analysis showed positive staining for KIT. Accordingly, the tumor was diagnosed as an intermediate- risk malignant gastrointestinal stromal tumor (GIST) for which the patient was followed. In January 2002, an abdominal CT scan revealed multiple hepatic tumors and a lower abdominal tumor, and the patient was diagnosed with liver metastases and peritoneal disseminations from GIST. After informed consent was provided, chemotherapy with 400 mg/day imatinib was initiated. The patient demonstrated a partial response 2 months after treatment. At 12 years 8 months after the diagnosis of liver metastasis and peritoneal disseminations, the patient shows no sign of recurrence.

Four Acacia senegal samples, one control (Mw 6.2×105 g/mol) and three enhanced samples with different molecular weights ranging from 1.2×106–2.5×106 g/mol were fractionated using hydrophobic interaction chromatography (HIC) into two fractions, hydrophilic (fraction 1, yield ∼80%) and hydrophobic (fraction 2, yield ∼2%). The elution profile and weight average molecular weight of fraction 1 were similar to the starting materials but contained slightly more arabinogalactan protein (AGP) component. On the other hand, the AGP peak was almost completely removed from Fraction 2. The Mw for fraction 2 was ∼1.1×105 g/mol and contained 4.9×107 g/mol. These fractions plus the whole gum were also analysed by ELISA (enzyme linked immunosorbent assay). The results showed that the interaction with an A. senegal specific antibody (SY CC7) is the same for the whole gum sample and its fractions, indicating a common, widely distributed epitope. One sample with the highest molecular weight (2.5×106 g/mol) showed a slightly different interaction, displaying a lower sensitivity, attributed to the formation of a more compact hydrophobic form of AGP. This is in accord also with the observations on the same sample using spectroscopic methods which was attributed to dehydration of the COOH uronic acid group. Examination of the commercially available Acacia(sen) SUPER GUM™ (EM2—Mw ∼1.8×106 g/mol) with three different antibodies (SY CC7, UC-SEN-PS-01 and UC-SEY-PS-01) showed the response to be identical to that of control A. senegal gum. These results demonstrate how immunological techniques, in this instance ELISAs, can be utilised to indicate differences between gum samples and to determine the limit of maturation of Acacia(sen) SUPER GUM™.

Acacia senegal is the major gum arabic species used in commercial emulsification for the production of beverages and flavor concentrates. This paper examines the effect of gum concentration, molecular weight parameters and homogenization conditions on the droplet size and stability of emulsions prepared using a conventional commercial A. senegal product and a series of A. senegal test gums that were prepared by a controlled maturation process, including a new commercial product produced by this process (Acacia ( sen ) SUPER GUM™ EM2). Pressure homogenization after vigorous stirring produced the best results. At concentrations below 20%, commercial gum arabic weight average molecular weight M W ca. 6×10 5 Da produced emulsions which were not stable under accelerated stress conditions. When the weight average M W was increased to a range 1–2.5×10 6 Da, the droplet size was reduced and the stability was greatly increased, even at a 5% gum concentration. After pressure homogenization, sub-micron droplet sizes could be produced which exhibited complete stability during stress testing at 60 °C and after longer-term storage. A model is proposed to account for the greater effectiveness of the matured gums, whereby the arabinogalactan protein complex unfolds as a result of pressure homogenization and occupies a greater volume around the oil droplet, which in turn produces greater stabilization.

We propose a new algorithm that is effective for objects that are shared among threads but are not contended for in SMP environments. We can remove the overhead of the serialization between lock and other non-lock operations and avoid the latency of complex atomic operations in most cases. We established the safety of the algorithm by using a software tool called Spin. The experimental results from our benchmarking on an SMP machine using Intel Xeon processors revealed that our algorithm could significantly improve efficiency by 80% on average compared to using complex atomic instruction.

今回われわれは,穿孔性虫垂炎にて発症し,術後に診断された1例と術前に確定診断しえた1例の盲腸癌の2例を経験したので報告する.症例1は, 61歳,男性.発熱,下痢,腹痛を主訴に当院受診.腹腔全般に腹水を認め,腹腔試験穿刺にて膿汁を認めた.汎発性腹膜炎の診断にて緊急開腹したところ,多量の膿性腹水と虫垂の穿孔を認め,回盲部が腫瘤状に一塊となっていたため,回盲部切除を施行した.病理組織診断は,中分化腺癌であった.症例2は, 68歳,男性.発熱,腹痛を主訴に当科を受診. CT上,穿孔性虫垂炎による腹腔内膿瘍と診断したが,回盲部に腫瘤を認めたため,保存的治療を優先した.炎症消退後の大腸内視鏡にて虫垂根部を閉塞する形の腫瘤を認め,病理組織診断は,中分化腺癌であった.手術所見は,腫大した虫垂,陳旧性膿瘍,回盲部腫瘤を認め,結腸右半切除およびD3郭清を施行した.

Polymerase chain reaction (PCR) primers were prepared to amplify the DNA fragment between the genomic DNA sequence adjacent to the 5′-integration site of Roundup Ready® (RR) soybeans neighboring the transgene and the parts of the coding region of the transgene, together with the primer set for the internal host gene, the α' subunit of β-conglycinin storage protein gene (Cong gene). Using the primers for the transgene and Cong gene, the DNA fragments were amplified from the individual genomic DNAs prepared from 72 samples of RR soybean isolated from imported soybean seeds labeled “not segregated.” Although the frequency of alterations of the nucleotide sequences in both the transgene and Cong gene were almost the same, the mutations that caused alterations to the amino acid sequence were more highly repressed in the transgene than in the Cong gene. In the nucleotide sequence upstream of the coding region of the transgene, the number of alterations of the nucleotide in the proximal promoter region was smaller than that in the further upstream region, suggesting that the mutants missing or being weak glyphosate-tolerance by an alteration of the critical nucleotide sequences in the promoter or coding region might be discarded artificially. It is supposed that the selective bias on the transgene might be extremely high, which indicates that the nucleotide sequence of the transgene might be stable and maintained in inbred RR soybean lines.

The photoinduced dynamics in a perovskite-type vanadate LaVO 3 has been studied by femtosecond time-resolved pump–probe spectroscopy. By irradiation with light in the orbital-ordered phase, an anisotropic large reflectivity change appears within the time resolution of about 200 fs. It is attributable to the instantaneous melting of the orbital order. One excitation photon is found to induce the disordering of the t 2g orbitals over about 60 V-sites. The orbital order partially recovers through thermalization with the lattice vibrations in a few picoseconds.

Inter-laboratory evaluation studies were conducted for the ELISA methods for allergic substances (buckwheat). Extracts of snack, bun and udon spiked with buckwheat standard protein at a level of 5-20 ng/mL as sample solutions were analyzed in replicate at 10 laboratories. Coefficients of variation (CVs) of the ELISA methods using a Buckwheat Protein ELISA Kit (Buckwheat kit) and a FASTKIT Buckwheat ELISA kit (Buckwheat ELISA kit) were mostly below 10%. Mean recoveries of the buckwheat standard protein from the food extracts were over 40% in the two ELISA methods. Repeatability relative standard deviations of buckwheat standard protein in three food extracts were in the ranges of 6.8-78.5% and 5.0-33.9% for the Buckwheat kit and the Buckwheat ELISA kit, respectively. Reproducibility relative standard deviations of buckwheat standard protein in three food extracts were 11.9-69.5% and 16.5-34.1% for the Buckwheat kit and the Buckwheat ELISA kit, respectively. The detection limits of both ELISA methods were 1 ng/mL in sample solutions. These results suggest that the notified ELISA methods are reliable and reproducible for the inspection of buckwheat protein levels in extracts of snack, bun and udon.

A 64-year-old woman underwent cholecystectomy for treatment of cholecystolithiasis in January 2005. Pathological examination rendered a diagnosis of gallbladder carcinoma. Wedge resection of the liver and dissection of the lymph nodes was performed. No tumor cells in either the liver nodule or lymph nodes were found during pathological examination. At 4 years after surgery, paraaortic lymph node recurrence was confirmed by computed tomography (CT). Gemcitabine was administered once weekly for the first 3 weeks in a monthly cycle, but the tumor continued to increase in size. Gemcitabine was then switched to TS-1, after which it was changed to cisplatin because of continued tumor growth. After 35 courses of chemotherapy, CT showed the disappearance of the paraaortic lymph node, and the patient achieved a complete response. She is currently free of disease at 9 years after surgery.

A 74-year-old woman underwent distal gastrectomy and D1+ α dissection for the treatment of gastric cancer (pT2a, pN2, H0, P0, M0, Stage IIIA) in February 2008. She was treated with adjuvant postoperative chemotherapy consisting of TS-1. However, 32 months after the operation, paraaortic lymph node recurrence was confirmed by computed tomography (CT). She was treated with combined TS-1 and cisplatin chemotherapy. After 14 courses, CT revealed that the paraaortic lymph node metastasis had disappeared, and a complete response was attained. The patient is currently disease-free, 6 years after the operation.

The wrapping process, which is the final finishing process for rolls (products), must meet the needs of a larger wrapping volume and a larger variety of wrapping specifications than ever before. As production control in the entire plant becomes computerized, roll wrapping machines also receive wrapping data on-line, paving the way for automatic wrapping to process a large volume and a large variety of specifications. Now we have developed a roll wrapping machine that can process rolls produced by several paper machines, by increasing its wrapping capacity as well as enabling it to follow a large variety of wrapping specifications.This machine consists of a bar code reader, inkjet printer, wrapping machine, and labeler. Operation data for each part can be set or changed easily through a touch panel. The operator training will be completed in a relatively short time.This machine has demonstrated high reliability as equipment that plays an important role in the final finishing process for rolls.

The spatial resolution of a conventional magneto-optical Kerr microscope, compared with those of conventional optical microscopes, inevitably deteriorates owing to oblique illumination. An approach to obtaining the maximum spatial resolution using multiple images with different illumination directions is demonstrated here. The method was implemented by rotating the illumination path around the optical axis using a motorized stage. The Fourier transform image of the observed magnetic domain indicates that the spatial frequency component that is lost in the conventional method is restored.

A multifilamentary Nb3Sn composite conductor for AC use was fabricated by the internal tin-core method. In this conductor, Nb–1at.%W is used for filaments and Cu–1at.%Ni for matrix. The conductor has 33,252 filaments of a diameter of 0.36 μm. Samples of conductor were heat treated at 450–700°C for 24–740 h and the critical current and magnetization were measured at 4.2 K in transverse fields up to 5 T. Overall critical current density of 4.9 GA/m2 at 1.5 T is obtained with a heat treated at 600°C for 200 h. The effective filament diameter was estimated to be 3–5 μm at 1.5 T.

We report strong instantaneous photoinduced absorption in the quasi-one-dimensional Mott insulator ${\mathrm{Sr}}_{2}{\mathrm{CuO}}_{3}$ in the IR spectral region. The observed photoinduced absorption is to an even-parity two-photon state that occurs immediately above the absorption edge. Theoretical calculation based on a two-band extended Hubbard model explains the experimental features and indicates that the strong two-photon absorption is due to a very large dipole coupling between nearly degenerate one- and two-photon states. Room temperature picosecond recovery of the optical transparency suggests the strong potential of ${\mathrm{Sr}}_{2}{\mathrm{CuO}}_{3}$ for all-optical switching.

TIAP, a murine homologue of human survivin, is a member of the inhibitor of apoptosis (IAP) family and is specifically expressed at G2/M phase of the cell cycle. To elucidate regulatory mechanisms of the cycle-dependent expression, we have analyzed the promoter region of TIAP/mouse survivin (m-survivin). The 5'-flanking region of the TIAP/m-survivin gene contained a TATA-less promoter, two AP2 sites, three NF-kB sites, one Sp1 site, many cell cycle-dependent elements (CDEs) and one cell cycle gene homology region (CHR). Primer extension and 5'-rapid amplification of cDNA ends identified one transcription start site at position -100 upstream of the ATG start site (+1). TIAP/m-survivin promoter-luciferase analysis identified a minimal promoter region within the most proximal -271 bp upstream of the ATG start site, and the region between -410 and -272 was critical for the enhancer activity. The combination between the CHR at -51 and the CDE at -57 is also essential for the cell cycle-dependent expression. Mutation of the CDE/CHR element and the enhancer elements may cause disordered expression of TIAP/m-survivin to affect cell survival and oncogenesis.

Ultrafast spin dynamics in ferromagnetic half-metallic compound Sr2FeMoO6 is investigated by pump-probe measurements of the magneto-optical Kerr effect. The half-metallic nature of this material gives rise to anomalous thermal insulation between spins and electrons and allows us to pursue the spin dynamics from a few to several hundred picoseconds after the optical excitation. The optically detected magnetization dynamics clearly shows the crossover from microscopic photoinduced demagnetization to macroscopic critical behavior with universal power law divergence of relaxation time for a wide dynamical critical region.

In the past, one winder and one wrapping machine used to be arranged to process paper produced by one paper machine. In recent years, however, control of production data by computer has made great progress, and now we are in an environment where production data of wound rolls as finished products can be rapidly processed online.Therefore. we have been able to develop a wrapping machine with a large processing capacity, that can automatically process various types of wound rolls produced by more than one paper machine to save labor, space and energy required by wrapping at a mill.Our wrapping machine consists of equipment such as bar code reader, printer, wrapping machine, marking device and labelling device. Even a non skilled worker will be able to operate our wrapping machine in a short time because each equipment is reliable and can stand continuous operation for a long time, and also because of features such as complete interlocking and easy input setting, changing and monitoring by touch panel, based on our wide experience and achievements.Through the use of our wrapping machine, complete wrapping of wound products and display of contents of finished products can be performed.

The inhibitor of apoptosis (IAP) proteins form a highly conserved gene family that prevents cell death in response to a variety of stimuli. Herein we describe a newly defined murine IAP, designatedTiap,that proved to be a murine homologue of human survivin based on sequence comparison. TIAP has one baculovirus IAP repeat and lacks a C-terminal RING finger motif. TIAP interacted with the processed form of caspase 3 and inhibited caspase-induced cell death. Histological examinations revealed that TIAP is expressed in growing tissues such as thymus, testis, and intestine of adult mice and many tissues of embryos. Inin vitrostudies, TIAP was induced in splenic T cells activated with anti-CD3 antibody or Con A, and the expression of TIAP was up-regulated in synchronized NIH 3T3 cells at S to G2/M phase of the cell cycle. We propose that during cell proliferation, cellular protective activity may be augmented with inducible IAPs such as TIAP.

アニオン交換基としてジエチルアミノ基および2-ヒドロキシエチルアミノ基を有するグラフト高分子鎖を多孔性中空糸膜の細孔表面に固定した。オボトランスフェリン (OTf) およびオボムコイド (OM) の二成分タンパク質溶液をこの中空糸膜に透過させた。破過曲線の測定から, 膜に吸着していたOTfに換わって選択吸着性のより高いOMが吸着するという置換吸着が起きることがわかった。また, OMは多層でグラフト高分子鎖に吸着した。タンパク質溶液の透過流量を変えても無次元流出液量とタンパク質の吸着量との関係を示す曲線は一致した。これより, タンパク質がアニオン交換基まで拡散移動する過程の抵抗が無視でき, さらにOTfとOMとの間での置換吸着が十分速いことが示された。

Leiomyosarcomas of the duodenum are relatively rare. The common symptoms included abdominal pain, intestinal bleeding and a mass. Cases presenting with intraabdominal bleeding are very rare. We report such a case presenting with intraabdominal bleeding. A 43-year-old man was admitted to the hospital because of a severe pain mainly located in the upper abdomen. Abdominal ultrasonography revealed a huge mass with moderate intraabdominal fluid. And by puncture, fluid was thought to be blood. Anemia was seen on admission but it did not get worse by blood transfusion. With further examinations, the tumor was suspected to be a duodenal mass growing extraluminally. Laparotomy was performed. The tumor with the maximum diameter of 20cm easily bled and was unable to be loosen from the antrum, duodenum and pancreas. At laparotomy, about 500ml of bloody fluid was seen in the abdomen, but no evidence of rupture of the tumor nor bleeding site on the vessels was proceived. The sourse of bleeding was still unclear.

In this paper, we give an explicit formula for computing Fourier coefficients of octahedral newforms of weight one associated to three-division points of elliptic curves.

The Nb/sub 3/Sn superconductor possesses a higher critical temperature than the NbTi strand. Therefore, it is now possible to make highly stable superconducting strands. We examined the manufacturing process of AC Nb/sub 3/Sn strands. The internal Sn diffusion process showed a higher critical current density than the conventional process. Nb/sub 3/Sn strands for AC use have a high Jc with low temperature reaction heat treatment, because they have fine filaments to decrease AC loss. We made a 400 kVA class superconducting coil using the developed Nb/sub 3/Sn cable with the React and Wind method. The loss density of this coil was 25.7 MW/m/sup 3/ at the point just before the quench. In this case, the temperature of the cable increases about 3.39 K. This means that the coil using Nb/sub 3/Sn cables has a very high stability in AC use.

A clinical study was carried out on pazufloxacin (PZFX) in 137 patients including shigellosis, Salmonella enteritis, enteropathogenic Esherichia coli enteritis and cholera, and carriers of these pathogens. Antibacterial activity of PZFX against clinical isolates, fecal concentration of PZFX and effects of PZFX on fecal microflora were also investigated. The overall clinical efficacy rate was 97.2%. The bacteriological efficacy rates were 98.2% against Shigella spp., 81.8% against Salmonella spp., 50% against Vibrio cholerae O1, and 100% against E. coli, V. parahaemolyticus, Aeronomas spp., Plesionomas shigelloides and V. cholerae non-O1, respectively. Side effect (epigastralgia) was observed in 1 of 130 cases (0.8%). The rate of abnormal laboratory findings was 11.2% (11/98). These were mainly elevation of GOT and/or GPT and increased eosinophils. The clinical usefulness rate was 95.2%. The MIC90 values of PZFX against Shigella spp., Salmonella spp. and E. coli were 0.025, 0.025 and 0.025 micrograms/ml, respectively. The results of fecal drug concentration and the effects on fecal microflora in one patient were compatible with those obtained in healthy volunteers.

We report an 82-year-old woman with severe iron deficiency anemia who was found to have gastric antral vascular ectasia (GAVE). As the required repeated blood transfusion for the anemia and did not respond to various medical treatments, she was referred for antrectomy. The pathogenesis of GAVE is still obscure and may involve many factors. In our patient, immunohistochemical studies of the resected stomach disclosed a marked increase of neuroendocrine cells. The majority of these hyperplastic neuroendocrine cells, furthermore, showed immunoreactivity for 5-hydroxytryptamine (serotonin). These findings suggest that neuroendocrine mediators, serotonin in particular, may have been responsible for the local vasodilatation.

Filament coupling induced by the proximity effect was studied through AC susceptibility measurements an Cu-matrix NbTi multifilamentary wires. The sample wires having different interfilamentary spacings ranging from 0.35 to 1.04 /spl mu/m and various twist pitches were prepared from the VAMAS (Versailles Project on Advanced Materials and Standards) reference sample H-1, which has a filament number of 931. The measurements were carried out in each of the two different field directions, parallel and perpendicular, to the wire axis. It has been found that the value of perpendicular field to suppress the proximity effect coupling is two orders of magnitude larger than that of the parallel field. In the perpendicular field, the twist of the wires affects the occurrence of the coupling: the filaments couple at higher temperature and higher field with longer twist pitch. On the contrary, the twist pitch dependence of the coupling has not been observed in a parallel field. In addition, the effect of transport current on the coupling has been examined. >

Plantlet regeneration from leaf blade segment of horseradish (Armoracia rusticana L.) was enhanced proportionally with the addition of 2, 4-dichlorophenoxy acetic acid (2, 4-D) and 6-benzyladenine (BA) to the medium but inversely with leaf maturity. Plantlets regenerated directly from immature leaf blades most efficiently on a medium supplemented with 0.1 μM 2, 4-D and 0.1 μM BA. Callus tended to be induced in the meida containing higher than 0.1 μM 2, 4-D, especially, green and compact morphogenic callus, in media supplemented with up to 0.1 μM 2, 4-D. Some morphogenic calli differentiated shoots in the initial medium, whereas those induced in the medium with 1.0 μM 2, 4-D and 1.0 μM BA needed to be subcultured in a growth regulator-free medium to differentiate shoots and develop into plantlets. Immature leaf explants responded better than did mature ones to the exogenous plant growth regulators for plant regeneration. All immature leaf explants collected in June formed shoots in the media with 0.1 μM 2, 4-D ; those collected in October developed into plantlet not only through direct shoot formation but also by callus formation in that medium. Petiole segments which were maintained in MS medium developed shoots directly on the medium with 0.1 to 1.0 μM BA. Morphogenic callus induction and subsequent shoot differentiation from petiole occurred on media containing with 0.1 μM 2, 4-D and from 0.1 to 1.0 μM BA.

We evaluated the conditions of fixation for ultrastructurally demonstrating the endogenous peroxidase (PO) activity of macrophages in biopsied human liver. The application of microwaving and immersion fixation with tannic acid and aldehydes allowed excellent visualization of PO activity in the nuclear envelope (NE), rough endoplasmic reticulum (rER), and cytoplasmic granules (CG), with good preservation of cellular ultrastructures. The macrophages with PO activity showed one of the following five patterns of PO localization: positive in both the NE and rER but negative in the CG (type 1); negative in both the NE and rER but positive in the CG (type 2); negative in the NE but positive in both the rER and CG (type 3); positive in all three (type 4); PO negative (type 5). The type 1 cells resembled typical Kupffer cells, type 2 cells monocytes, and type 3 and 4 cells the exudate-resident macrophages considered to be a transitional form between exudate and resident macrophages. Type 5 cells may also be a transitional form between the exudate and resident macrophage, or an end-stage macrophage derived from exudate macrophages which have lost their PO activity. Tannic-acid-aldehyde immersion fixation with microwaving may be a useful method in the study of the PO activities of macrophages in biopsied human liver specimens.

Superconducting cable for power applications must have high stability against power system failures. The Nb3Sn superconductor is expected to be used for AC power machines from this point of view. It is very important to estimate the AC loss and stability margin under practical conditions. We have developed an Nb3Sn 400-kVA class AC coil composed of a six-stranded cable with a stainless steel center strand. The Nb3Sn cable was made by the React and Wind method. In fabricating the coil, we have given careful consideration to the stress of the reacted Nb3Sn. From the analysis of the results, the major component of AC loss was the coupling loss. The temperature margin was as high as 4.19K at the cable just before quenching. The reduced critical current due to the temperature rise was found to be consistent with the quench current. The Nb3Sn coil was proven to have a temperature margin large enough to be robust against power system failures.

A 78-year-old woman was admitted to our hospital because of abdominal pain. She was diagnosed with complex (type IV) paraesophageal hiatal hernia, for which an operation was performed. At laparotomy, a 50 cm long ileum was found to have herniated into the thoracic cavity through the esophageal hiatus along with the sliding hiatal hernia of the stomach. Both the organs were reduced to the abdominal cavity. The hiatal hernia defect (diameter, 7cm) was repaired with a direct suture, and the gastric fundus was sutured to the diaphragm. Presently, 6 years have passed since the operation, there is no sign of recurrence.