5,706 results on '"Talman A"'
Search Results
52. Transcriptomics reveal stretched human pluripotent stem cell-derived cardiomyocytes as an advantageous hypertrophy model
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Pohjolainen, Lotta, Ruskoaho, Heikki, and Talman, Virpi
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- 2022
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53. Participation in Daily Life for Adults with Profound Intellectual (and Multiple) Disabilities: How High Do They Climb on Shier's Ladder of Participation?
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Talman, Lena, Stier, Jonas, Wilder, Jenny, and Gustafsson, Christine
- Abstract
Participation is the goal of Swedish disability policy, but it is difficult to achieve for adults with profound intellectual (and multiple) disabilities (PI(M)D). Since these adults are dependent on others in every aspect of their lives, others control their ability to participate in everyday life decisions. This study used observations, analyzed with Shier's ladder of participation, to elucidate and describe participation in daily life for adults with PI(M)D living in a group home. The results showed that the adults often reached the first three levels of Shier's ladder, one adult reached the fourth level once, and no one reached the fifth level. Participation on a higher level, therefore, seems hard to reach for adults. Staff members' attitudes toward the adults' capability can also be a barrier to participation. Applying Shier's ladder of participation can provide valuable information that might lead to increased participation in daily life for adults with PI(M)D.
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- 2021
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54. Student selection in radiography education. A narrative review
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Holmström, A., Haavisto, E., and Talman, K.
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- 2022
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55. Phase Measurement for Driven Spin Oscillations in a Storage Ring
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Hempelmann, N., Hejny, V., Pretz, J., Soltner, H., Augustyniak, W., Bagdasarian, Z., Bai, M., Barion, L., Berz, M., Chekmenev, S., Ciullo, G., Dymov, S., Eversmann, D., Gaisser, M., Gebel, R., Grigoryev, K., Grzonka, D., Guidoboni, G., Heberling, D., Hetzel, J., Hinder, F., Kacharava, A., Kamerdzhiev, V., Keshelashvili, I., Koop, I., Kulikov, A., Lehrach, A., Lenisa, P., Lomidze, N., Lorentz, B., Maanen, P., Macharashvili, G., Magiera, A., Mchedlishvili, D., Mey, S., Müller, F., Nass, A., Nikolaev, N. N., Nioradze, M., Pesce, A., Prasuhn, D., Rathmann, F., Rosenthal, M., Saleev, A., Schmidt, V., Semertzidis, Y., Shmakova, Y. Senichev V., Silenko, A., Slim, J., Stahl, A., Stassen, R., Stephenson, E., Stockhorst, H., Ströher, H., Tabidze, M., Tagliente, G., Talman, R., Engblom, P. Thörngren, Trinkel, F., Uzikov, Yu., Valdau, Yu., Valetov, E., Vassiliev, A., Weidemann, C., Wrońska, A., Wüstner, P., Zuprański, P., and Żurek, M.
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Physics - Accelerator Physics ,13.40.Em, 11.30.Er, 29.20.D, 29.20.dg, 29.20.db - Abstract
This paper reports the first simultaneous measurement of the horizontal and vertical components of the polarization vector in a storage ring under the influence of a radio frequency (rf) solenoid. The experiments were performed at the Cooler Synchrotron COSY in J\"ulich using a vector polarized, bunched $0.97\,\textrm{GeV/c}$ deuteron beam. Using the new spin feedback system, we set the initial phase difference between the solenoid field and the precession of the polarization vector to a predefined value. The feedback system was then switched off, allowing the phase difference to change over time, and the solenoid was switched on to rotate the polarization vector. We observed an oscillation of the vertical polarization component and the phase difference. The oscillations can be described using an analytical model. The results of this experiment also apply to other rf devices with horizontal magnetic fields, such as Wien filters. The precise manipulation of particle spins in storage rings is a prerequisite for measuring the electric dipole moment (EDM) of charged particles.
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- 2018
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56. Malian field isolates provide insight into Plasmodium malariae intra-erythrocytic development and invasion.
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Dao, Francois, Niangaly, Amadou, Sogore, Fanta, Wague, Mamadou, Dabitao, Djeneba, Goita, Siaka, Hadara, Aboubacrin S., Diakite, Ousmaila, Maiga, Mohamed, O. Maiga, Fatoumata, Cazevieille, Chantal, Cassan, Cecile, Talman, Arthur M., Djimde, Abdoulaye A., Marin-Menendez, Alejandro, and Dembélé, Laurent
- Abstract
Plasmodium malariae is the third most prevalent human malaria parasite species and contributes significantly to morbidity. Nevertheless, our comprehension of this parasite's biology remains limited, primarily due to its frequent co-infections with other species and the lack of a continuous in vitro culture system. To effectively combat and eliminate this overlooked parasite, it is imperative to acquire a better understanding of this species. In this study, we embarked on an investigation of P. malariae, including exploring its clinical disease characteristics, molecular aspects of red blood cell (RBC) invasion, and host-cell preferences. We conducted our research using parasites collected from infected individuals in Mali. Our findings revealed anaemia in most of P. malariae infected participants presented, in both symptomatic and asymptomatic cases. Regarding RBC invasion, quantified by an adapted flow cytometry based method, our study indicated that none of the seven antibodies tested, against receptors known for their role in P. falciparum invasion, had any impact on the ability of P. malariae to penetrate the host cells. However, when RBCs were pre-treated with various enzymes (neuraminidase, trypsin, and chymotrypsin), we observed a significant reduction in P. malariae invasion, albeit not a complete blockade. Furthermore, in a subset of P. malariae samples, we observed the parasite's capability to invade reticulocytes. These results suggest that P. malariae employs alternative pathways to enter RBCs of different maturities, which may differ from those used by P. falciparum. Author summary: Malaria is a parasitic disease caused by Plasmodium parasite genus transmitted by Anopheles mosquitoes. Five different species are involved in human infection, and two of them have been largely studied, P. falciparum and P. vivax. However, within an eradication agenda in mind, the other three less explored species should not be neglected. In this study, we focused on the investigation of one of this species, P. malariae, for which little is known, mainly due to the lack of a continuous in vitro system and the frequency of co-infections with other species. Here, we studied the clinical manifestations of the infections, optimised a flow cytometry-based method aiming to decipher molecular interactions between the parasite and the red blood cells, the main parasite host-cell. Our results indicate that P. malariae might use different invasion pathways than other Plasmodium species, including the possibility of invading red blood cells of distinct maturities. [ABSTRACT FROM AUTHOR]
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- 2025
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57. The connection between zero chromaticity and long in-plane polarization lifetime in a magnetic storage ring
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Guidoboni, G., Stephenson, E. J., Wrońska, A, Bagdasarian, Z., Bsaisou, J., Chekmenev, S., Dymov, S., Eversmann, D., Gaisser, M., Gebel, R., Hejny, V., Hempelmann, N., Hinder, F., Kacharava, A., Keshelashvili, I., Kulessa, P., Lenisa, P., Lehrach, A., Lorentz, B., Maanen, P., Maier, R., Mchedlishvili, D., Mey, S., Nass, A., Pesce, A., Orlov, Y., Pretz, J., Prasuhn, D., Rathmann, F., Rosenthal, M., Saleev, A., Semertzidis, Y. K., Senichev, Y., Shmakova, V., Stockhorst, H., Ströher, H., Talman, R., Thörngren-Engblom, P., Trinkel, F., Valdau, Yu., Weidemann, C., Wüstner, P., and Zyusin, D.
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Physics - Accelerator Physics ,Nuclear Experiment ,Physics - Instrumentation and Detectors - Abstract
In this paper, we demonstrate the connection between a magnetic storage ring with additional sextupole fields set so that the x and y chromaticities vanish and the maximizing of the lifetime of in-plane polarization (IPP) for a 0.97-GeV/c deuteron beam. The IPP magnitude was measured by continuously monitoring the down-up scattering asymmetry (sensitive to sideways polarization) in an in-beam, carbon-target polarimeter and unfolding the precession of the IPP due to the magnetic anomaly of the deuteron. The optimum operating conditions for a long IPP lifetime were made by scanning the field of the storage ring sextupole magnet families while observing the rate of IPP loss during storage of the beam. The beam was bunched and electron cooled. The IPP losses appear to arise from the change of the orbit circumference, and consequently the particle speed and spin tune, due to the transverse betatron oscillations of individual particles in the beam. The effects of these changes are canceled by an appropriate sextupole field setting., Comment: 18 pages, 18 figures, prepared for Phys. Rev. Accel. Beams
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- 2017
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58. Phase locking the spin precession in a storage ring
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Hempelmann, N., Hejny, V., Pretz, J., Stephenson, E., Augustyniak, W., Bagdasarian, Z., Bai, M., Barion, L., Berz, M., Chekmenev, S., Ciullo, G., Dymov, S., Etzkorn, F. -J., Eversmann, D., Gaisser, M., Gebel, R., Grigoryev, K., Grzonka, D., Guidoboni, G., Hanraths, T., Heberling, D., Hetzel, J., Hinder, F., Kacharava, A., Kamerdzhiev, V., Keshelashvili, I., Koop, I., Kulikov, A., Lehrach, A., Lenisa, P., Lomidze, N., Lorentz, B., Maanen, P., Macharashvili, G., Magiera, A., Mchedlishvili, D., Mey, S., Müller, F., Nass, A., Nikolaev, N. N., Pesce, A., Prasuhn, D., Rathmann, F., Rosenthal, M., Saleev, A., Schmidt, V., Semertzidis, Y., Shmakova, V., Silenko, A., Slim, J., Soltner, H., Stahl, A., Stassen, R., Stockhorst, H., Ströher, H., Tabidze, M., Tagliente, G., Talman, R., Engblom, P. Thörngren, Trinkel, F., Uzikov, Yu., Valdau, Yu., Valetov, E., Vassiliev, A., Weidemann, C., Wrońska, A., Wüstner, P., Zuprański, P., and Żurek, M.
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Physics - Accelerator Physics - Abstract
This letter reports the successful use of feedback from a spin polarization measurement to the revolution frequency of a 0.97 GeV/$c$ bunched and polarized deuteron beam in the Cooler Synchrotron (COSY) storage ring in order to control both the precession rate ($\approx 121$ kHz) and the phase of the horizontal polarization component. Real time synchronization with a radio frequency (rf) solenoid made possible the rotation of the polarization out of the horizontal plane, yielding a demonstration of the feedback method to manipulate the polarization. In particular, the rotation rate shows a sinusoidal function of the horizontal polarization phase (relative to the rf solenoid), which was controlled to within a one standard deviation range of $\sigma = 0.21$ rad. The minimum possible adjustment was 3.7 mHz out of a revolution frequency of 753 kHz, which changes the precession rate by 26 mrad/s. Such a capability meets a requirement for the use of storage rings to look for an intrinsic electric dipole moment of charged particles.
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- 2017
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59. Spin tune mapping as a novel tool to probe the spin dynamics in storage rings
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Saleev, A., Nikolaev, N. N., Rathmann, F., Augustyniak, W., Bagdasarian, Z., Bai, M., Berz, M., Chekmenev, S., Ciullo, G., Dymov, S., Eversmann, D., Gaisser, M., Gebel, R., Grigoryev, K., Grzonka, D., Guidoboni, G., Heberling, D., Hempelmann, N., Hejny, V., Hetzel, J., Hinder, F., Kacharava, A., Kamerdzhiev, V., Keshelashvili, I., Koop, I., Kulikov, A., Lehrach, A., Lenisa, P., Lomidze, N., Lorentz, B., Maanen, P., Macharashvili, G., Mchedlishvili, D., Magiera, A., Mey, S., Nass, A., Pesce, A., Prasuhn, D., Pretz, J., Rosenthal, M., Schmidt, V., Semertzidis, Y., Senichev, Y., Shmakova, V., Silenko, A., Slim, J., Stahl, A., Stassen, R., Stephenson, E., Stockhorst, H., Ströher, H., Engblom, P. Thörngren, Tabidze, M., Tagliente, G., Talman, R., Trinkel, F., Uzikov, Yu., Valdau, Yu., Valetov, E., Vassiliev, A., Weidemann, C., Wrońska, A., Wüstner, P., and Zuprański, P.
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Physics - Accelerator Physics ,Nuclear Experiment ,Physics - Instrumentation and Detectors - Abstract
Precision experiments, such as the search for electric dipole moments of charged particles using storage rings, demand for an understanding of the spin dynamics with unprecedented accuracy. The ultimate aim is to measure the electric dipole moments with a sensitivity up to 15 orders in magnitude better than the magnetic dipole moment of the stored particles. This formidable task requires an understanding of the background to the signal of the electric dipole from rotations of the spins in the spurious magnetic fields of a storage ring. One of the observables, especially sensitive to the imperfection magnetic fields in the ring is the angular orientation of stable spin axis. Up to now, the stable spin axis has never been determined experimentally, and in addition, the JEDI collaboration for the first time succeeded to quantify the background signals that stem from false rotations of the magnetic dipole moments in the horizontal and longitudinal imperfection magnetic fields of the storage ring. To this end, we developed a new method based on the spin tune response of a machine to artificially applied longitudinal magnetic fields. This novel technique, called \textit{spin tune mapping}, emerges as a very powerful tool to probe the spin dynamics in storage rings. The technique was experimentally tested in 2014 at the cooler synchrotron COSY, and for the first time, the angular orientation of the stable spin axis at two different locations in the ring has been determined to an unprecedented accuracy of better than $2.8\mu$rad., Comment: 32 pages, 15 figures, 7 tables
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- 2017
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60. The Influence of Danish Cancer Patient Pathways on Survival in Deep-Seated, High-Grade Soft-Tissue Sarcomas in the Extremities and Trunk Wall: A Retrospective Observational Study.
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Thorn, Andrea, Seem, Kristoffer Michael, Talman, Maj-Lis, Engelmann, Bodil E., Sørensen, Michala Skovlund, Aggerholm-Pedersen, Ninna, Baad-Hansen, Thomas, and Petersen, Michael Mørk
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MEDICAL protocols ,SARCOMA ,EXTREMITIES (Anatomy) ,SCIENTIFIC observation ,RETROSPECTIVE studies ,DESCRIPTIVE statistics ,TREATMENT duration ,LONGITUDINAL method ,KAPLAN-Meier estimator ,METASTASIS ,SOFT tissue tumors ,TORSO ,CANCER patient psychology ,SURVIVAL analysis (Biometry) - Abstract
Simple Summary: Soft-tissue sarcomas (STSs) are rare cancers that are difficult to diagnose and treat due to their variability. In 2009, Denmark introduced the Cancer Patient Pathways for sarcomas (CPPs) to improve the survival of sarcoma patients by accelerating the diagnosis and treatment processes. This study examined whether the CPPs improved survival in patients with high-grade STSs. Our findings show that survival has improved since the CPPs were introduced and treatment delays have been reduced. This research highlights the importance of streamlined cancer care in improving patient outcomes. Background: Soft-tissue sarcomas (STSs) are rare and challenging to diagnose due to their heterogeneous presentation. In 2009, Denmark introduced the Cancer Patient Pathways for sarcomas (CPPs) to improve sarcoma treatment by streamlining diagnostic and therapeutic processes. The primary objective of this study is to evaluate the impact of the CPPs on the overall survival of patients with deep-seated, high-grade STSs, comparing outcomes from before and after CPP implementation. Methods: A retrospective cohort study was conducted using data from 712 patients diagnosed with high-grade STSs in the extremities or trunk wall between 2000 and 2018. Patients were grouped into pre-CPP (2000–2008) and post-CPP (2010–2018) cohorts. Overall survival was analyzed using Kaplan–Meier estimates. Results: The five-year overall survival improved from 43% in the pre-CPP cohort to 52% post-CPP (p = 0.05). Time-to-treatment was significantly reduced in the post-CPP cohort, with a median decrease of 3 days (18 vs. 15 days, p < 0.001). We found only a very weak tendency toward larger tumor sizes in the pre-CPP cohort and no difference regarding the percentage of patients that had distant metastases at diagnosis between cohorts. In the post-CPP cohort, the percentage of whoops operations decreased and the use of oncological services increased. Conclusions: After the introduction of the CPPs for the sarcoma patients, overall survival improved and time to treatment was reduced. This study highlights the importance of efficient referral pathways in improving cancer outcomes but cannot exclude that other factors could also have contributed. [ABSTRACT FROM AUTHOR]
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- 2024
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61. The Assessment of Emotional Intelligence in Social Care and Healthcare Student Selection: A Qualitative Descriptive Study
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Pienimaa, Anne, Talman, Kirsi, and Haavisto, Elina
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Background: Effective student selection methods are needed to identify applicants who are expected to complete their studies and succeed professionally. The assessment of emotional intelligence has recently been identified as an important element of student selection for nursing studies. Purpose: This small-scale study, conducted in Finland, sought to capture the content of emotional intelligence that is considered relevant to social care and healthcare student selection from the perspectives of social care and healthcare educators and professionals. Methods: Five semi-structured focus group interviews (n = 30) were conducted with the educators and professionals. The data were analysed qualitatively using both deductive and inductive content analyses. Findings: The analysis of the data identified participants' perspectives on: perception of emotions, understanding emotions, accepting emotions, emotional management, emotional expression, utilising emotions and emotional awareness in social contexts. The participating educators and professionals indicated that applicants should demonstrate basic abilities across all these aspects of emotional intelligence in order to cope with the demands of social care and healthcare studies. Conclusions: Findings support the notion of the comprehensive assessment of emotional intelligence in student selection contexts. By ascertaining whether students have adequate basic emotional intelligence abilities, the risk of emotional exhaustion during clinical practice could be reduced; higher education institutions may better be able to select applicants who are likely to complete their studies and who are willing and able to work as social care and healthcare professionals.
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- 2021
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62. Instruments for Assessing Reasoning Skills in Higher Education: A Scoping Review
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Talman, Kirsi, Vierula, Jonna, Kanerva, Anne-Maria, Virkki, Outi, Koivisto, Jaana-Maija, and Haavisto, Elina
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Reasoning skills are needed in the future work life. As such, it is important that reasoning skills be assessed in higher education, both in the selection phase and during education. This study aims to describe the instruments that are used to assess reasoning skills in higher education. The ultimate goal is to provide information upon which student selection methods may be developed. A computerised search was performed among nine databases, and seventeen articles were included. As a result, seven generic instruments that measure reasoning skills were identified. None of the included studies reported an assessment of reasoning skills during the student selection phase. The content of the reasoning skills' instruments focused on four categories: information processing, analysing, drawing conclusions and argumentation. None of the seven instruments addressed all four categories identified, although a few addressed three categories. To conclude, a comprehensive assessment of reasoning skills including the four identified categories is recommended in the higher education context. Further research is needed to assess the use of reasoning skills and relevant instruments for high stake purposes.
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- 2021
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63. Octupole Focusing Relativistic Self-Magnetometer Electric Storage Ring 'Bottle'
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Talman, Richard and Talman, John
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Physics - Accelerator Physics - Abstract
A method proposed for measuring the electric dipole moment (EDM) of a charged fundamental particle such as the proton, is to measure the spin precession caused by a radial electric bend field $E_r$, acting on the EDMs of frozen spin polarized protons circulating in an all-electric storage ring. The dominant systematic error limiting such a measurement comes from spurious spin precession caused by unintentional and unknown average radial magnetic field $B_r$ acting on the (vastly larger) magnetic dipole moments (MDM) of the protons. Along with taking extreme magnetic shielding measures, the best protection against this systematic error is to use the storage ring itself, as a "self-magnetometer"; the exact magnetic field average $\langle B_r\rangle$ that produces systematic EDM error, is nulled to exquisite precision by orbit position control. By using octupole rather than quadrupole focusing the restoring force can be vanishingly small for small amplitude vertical betatron-like motion yet strong enough at large amplitudes to keep all particles captured. This greatly enhances the magnetometer sensitivity. Any average radial magnetic field error $\langle\Delta B_r\rangle$ causes a vertical orbit shift between CW and CCW beams. Self-magnetometry measures this shift, enabling its cancellation. For the octupole-only ring proposed here the accuracy of magnetic field control is $\langle\Delta B_r\rangle\approx \pm 3\times10^{-16}\,$Tesla. This is small enough to reduce the systematic error in the proton EDM measurement into a range where realistically small deviations from standard model predictions can be measured. Though novel, the theoretical analysis given here for relativistic bottles, magnetic or electric or both, is elementary, and their behavior is predicted to be entirely satisfactory., Comment: 21 pages, 9 figures
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- 2015
64. ETEAPOT: symplectic orbit/spin tracking code for all-electric storage rings
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Talman, Richard M. and Talman, John D.
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Physics - Accelerator Physics - Abstract
Proposed methods for measuring the electric dipole moment (EDM) of the proton use an intense, polarized proton beam stored in an all-electric storage ring "trap". At the "magic" kinetic energy of 232.792 MeV, proton spins are "frozen", for example always parallel to the instantaneous particle momentum. This paper describes an accelerator simulation code, ETEAPOT, a new component of the Unified Accelerator Libraries (UAL), to be used for long term tracking of particle orbits and spins in electric bend accelerators, in order to simulate EDM storage ring experiments. Though qualitatively much like magnetic rings, the non-constant particle velocity in electric rings give them significantly different properties, especially in weak focusing rings. Like the earlier code TEAPOT (for magnetic ring simulation) this code performs \emph{exact tracking in an idealized (approximate) lattice} rather than the more conventional approach, which is \emph{approximate tracking in a more nearly exact lattice.} The BMT equation describing the evolution of spin vectors through idealized bend elements is also solved exactly---original to this paper. Furthermore the idealization permits the code to be exactly symplectic (with no artificial "symplectification"). Any residual spurious damping or anti-damping is sufficiently small to permit reliable tracking for the long times, such as the 1000 seconds assumed in estimating the achievable EDM precision., Comment: 22 pages, 3 figures. There is a closely related paper by the same authors: "EDM planning using ETEAPOT with a resurrected AGS Electron Analogue ring"
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- 2015
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65. EDM planning using ETEAPOT with a resurrected AGS Electron Analogue ring
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Talman, Richard M and Talman, John D
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Physics - Accelerator Physics - Abstract
There has been much recent interest in directly measuring the electric dipole moments (EDM) of the proton and the electron. Such a measurement will require storing a polarized beam of "frozen spin" particles in an all-electric storage ring. Only one such relativistic electric accelerator has ever been built---the "Electron Analogue" ring at Brookhaven National Laboratory in 1954. By chance this electron ring, long since dismantled, would have been appropriate both for measuring the electron EDM and to serve as an inexpensive prototype for the arguably more promising, but ten times more expensive, proton EDM measurement. Today it is cheaper yet to "resurrect" the Electron Analogue ring by simulating its performance computationally. This is one purpose for the present paper. To set up these calculations has required a kind of "archeological physics" to reconstitute the detailed Electron Analogue lattice design. The new UAL/ETEAPOT code, described in detail in an accompanying paper, has been developed for modeling storage ring performance, including (exact BMT) spin evolution, in electric rings. Illustrating its use, comparing its predictions with the old observations, and describing new expectations concerning spin evolution and code performance, are other goals of the paper. This paper describes the practical application of the ETEAPOT code and provides sample results, with emphasis on emulating lattice optics in the AGS Analogue ring for comparison with the historical maching studies and to predict the electron spin evolution they would have measured. To exhibit the ETEAPOT code performance and confirm its symplecticity, results are also given for 30 million turn proton spin tracking in an all-electric lattice that would be appropriate for a present day measurement of the proton EDM., Comment: 16 pages, 9 figures. There is a related accompnying paper by the same authors "ETEAPOT: symplectic orbit/spin tracking code for all-electric storage rings"
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- 2015
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66. A Storage Ring Experiment to Detect a Proton Electric Dipole Moment
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Anastassopoulos, V., Andrianov, S., Baartman, R., Bai, M., Baessler, S., Benante, J., Berz, M., Blaskiewicz, M., Bowcock, T., Brown, K., Casey, B., Conte, M., Crnkovic, J., Fanourakis, G., Fedotov, A., Fierlinger, P., Fischer, W., Gaisser, M. O., Giomataris, Y., Grosse-Perdekamp, M., Guidoboni, G., Haciomeroglu, S., Hoffstaetter, G., Huang, H., Incagli, M., Ivanov, A., Kawall, D., Khazin, B., Kim, Y. I., King, B., Koop, I. A., Larsen, R., Lazarus, D. M., Lebedev, V., Lee, M. J., Lee, S., Lee, Y. H., Lehrach, A., Lenisa, P., Sandri, P. Levi, Luccio, A. U., Lyapin, A., MacKay, W., Maier, R., Makino, K., Malitsky, N., Marciano, W. J., Meng, W., Meot, F., Metodiev, E. M., Miceli, L., Moricciani, D., Morse, W. M., Nagaitsev, S., Nayak, S. K., Orlov, Y. F., Ozben, C. S., Park, S. T., Pesce, A., Pile, P., Polychronakos, V., Podobedov, B., Pretz, J., Ptitsyn, V., Ramberg, E., Raparia, D., Rathmann, F., Rescia, S., Roser, T., Sayed, H. Kamal, Semertzidis, Y. K., Senichev, Y., Sidorin, A., Silenko, A., Simos, N., Stahl, A., Stephenson, E. J., Stroeher, H., Syphers, M. J., Talman, J., Talman, R. M., Tishchenko, V., Touramanis, C., Tsoupas, N., Venanzoni, G., Vetter, K., Vlassis, S., Won, E., Zavattini, G., Zelenski, A., and Zioutas, K.
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Physics - Accelerator Physics ,High Energy Physics - Experiment - Abstract
A new experiment is described to detect a permanent electric dipole moment of the proton with a sensitivity of $10^{-29}e\cdot$cm by using polarized "magic" momentum $0.7$~GeV/c protons in an all-electric storage ring. Systematic errors relevant to the experiment are discussed and techniques to address them are presented. The measurement is sensitive to new physics beyond the Standard Model at the scale of 3000~TeV., Comment: 8 pages, 3 figures
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- 2015
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67. Whole-cell modeling of E. coli colonies enables quantification of single-cell heterogeneity in antibiotic responses.
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Christopher J. Skalnik, Sean Y. Cheah, Mica Y. Yang, Mattheus B. Wolff, Ryan K. Spangler, Lee Talman, Jerry H. Morrison, Shayn M. Peirce, Eran Agmon, and Markus W. Covert
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- 2023
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68. Surrogates for rigidity and PIGD MDS-UPDRS subscores using wearable sensors
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Safarpour, Delaram, Dale, Marian L., Shah, Vrutangkumar V., Talman, Lauren, Carlson-Kuhta, Patricia, Horak, Fay B., and Mancini, Martina
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- 2022
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69. TURN-IT: a novel turning intervention program to improve quality of turning in daily life in people with Parkinson’s disease
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King, LA, Carlson-Kuhta, P, Wilhelm, JL, Lapidus, JA, Dale, ML, Talman, LS, Barlow, N, Mancini, M, and Horak, FB
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- 2022
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70. Tackling malaria transmission at a single cell level in an endemic setting in sub-Saharan Africa
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Dara, Antoine, Dogga, Sunil Kumar, Rop, Jesse, Ouologuem, Dinkorma, Tandina, Fatalmoudou, Talman, Arthur M., Djimdé, Abdoulaye, and Lawniczak, Mara K. N.
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- 2022
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71. Coordination of Oral Anticoagulant Care at Hospital Discharge (COACHeD): protocol for a pilot randomised controlled trial
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Holbrook, Anne M., Vidug, Kristina, Yoo, Lindsay, Troyan, Sue, Schulman, Sam, Douketis, James, Thabane, Lehana, Giilck, Stephen, Koubaesh, Yousery, Hyland, Sylvia, Keshavjee, Karim, Ho, Joanne, Tarride, Jean-Eric, Ahmed, Amna, Talman, Marianne, Leonard, Blair, Ahmed, Khursheed, Refaei, Mohammad, and Siegal, Deborah M.
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- 2022
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72. NLI Data Sanity Check: Assessing the Effect of Data Corruption on Model Performance.
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Aarne Talman, Marianna Apidianaki, Stergios Chatzikyriakidis, and Jörg Tiedemann
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- 2021
73. A Population-Based Long-Term Follow-Up of Soft Tissue Angiosarcomas: Characteristics, Treatment Outcomes, and Prognostic Factors
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Holm, Christina Enciso, primary, Ørholt, Mathias, additional, Talman, Maj-Lis, additional, Abebe, Kiya, additional, Thorn, Andrea, additional, Baad-Hansen, Thomas, additional, and Petersen, Michael Mørk, additional
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- 2024
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74. The average tree value for hypergraph games
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Kang, Liying, Khmelnitskaya, Anna, Shan, Erfang, Talman, Dolf, and Zhang, Guang
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- 2021
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75. Prediction of Pathologic Complete Response in Breast Cancer Patients Comparing Magnetic Resonance Imaging with Ultrasound in Neoadjuvant Setting
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Palshof, Frederik Knude, Lanng, Charlotte, Kroman, Niels, Benian, Cemil, Vejborg, Ilse, Bak, Anne, Talman, Maj-Lis, Balslev, Eva, and Tvedskov, Tove Filtenborg
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- 2021
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76. Relativistic Stern-Gerlach Deflection
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Talman, Richard
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Physics - Accelerator Physics - Abstract
Modern advances in polarized beam control should make it possible to accurately measure Stern-Gerlach (S-G) deflection of relativistic beams. Toward this end a relativistically covariant S-G formalism is developed that respects the opposite behavior under inversion of electric and magnetic fields. Not at all radical, or even new, this introduces a distinction between electric and magnetic fields that is not otherwise present in pure Maxwell theory. Experimental configurations (mainly using polarized electron beams passing through magnetic or electric quadrupoles) are described. Electron beam preparation and experimental methods needed to detect the extremely small deflections are discussed.
- Published
- 2016
77. Transcriptomics reveal stretched human pluripotent stem cell-derived cardiomyocytes as an advantageous hypertrophy model
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Lotta Pohjolainen, Heikki Ruskoaho, and Virpi Talman
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Gene expression ,Transcriptomics ,hiPSC-derived cardiomyocyte ,Cardiac hypertrophy ,Mechanical stretch ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Left ventricular hypertrophy, characterized by hypertrophy of individual cardiomyocytes, is an adaptive response to an increased cardiac workload that eventually leads to heart failure. Previous studies using neonatal rat ventricular myocytes (NRVMs) and animal models have revealed several genes and signaling pathways associated with hypertrophy and mechanical load. However, these models are not directly applicable to humans. Here, we studied the effect of cyclic mechanical stretch on gene expression of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) using RNA sequencing. hiPSC-CMs showed distinct hypertrophic changes in gene expression at the level of individual genes and in biological processes. We also identified several differentially expressed genes that have not been previously associated with cardiomyocyte hypertrophy and thus serve as attractive targets for future studies. When compared to previously published data attained from stretched NRVMs and human embryonic stem cell-derived cardiomyocytes, hiPSC-CMs displayed a smaller number of changes in gene expression, but the differentially expressed genes revealed more pronounced enrichment of hypertrophy-related biological processes and pathways. Overall, these results establish hiPSC-CMs as a valuable in vitro model for studying human cardiomyocyte hypertrophy.
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- 2022
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78. The Prevalence of Human Plasmodium Species during Peak Transmission Seasons from 2016 to 2021 in the Rural Commune of Ntjiba, Mali
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Francois Dao, Laurent Dembele, Bakoroba Diarra, Fanta Sogore, Alejandro Marin-Menendez, Siaka Goita, Aboubacrin S. Haidara, Yacouba N. Barre, Cheick P. O. Sangare, Aminatou Kone, Dinkorma T. Ouologuem, Antoine Dara, Mamadou M. Tekete, Arthur M. Talman, and Abdoulaye A. Djimde
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Plasmodium ,epidemiology ,transmission ,seasonality ,Medicine - Abstract
Up-to-date knowledge of key epidemiological aspects of each Plasmodium species is necessary for making informed decisions on targeted interventions and control strategies to eliminate each of them. This study aims to describe the epidemiology of plasmodial species in Mali, where malaria is hyperendemic and seasonal. Data reports collected during high-transmission season over six consecutive years were analyzed to summarize malaria epidemiology. Malaria species and density were from blood smear microscopy. Data from 6870 symptomatic and 1740 asymptomatic participants were analyzed. The median age of participants was 12 years, and the sex ratio (male/female) was 0.81. Malaria prevalence from all Plasmodium species was 65.20% (95% CI: 60.10–69.89%) and 22.41% (CI: 16.60–28.79%) for passive and active screening, respectively. P. falciparum was the most prevalent species encountered in active and passive screening (59.33%, 19.31%). This prevalence was followed by P. malariae (1.50%, 1.15%) and P. ovale (0.32%, 0.06%). Regarding frequency, P. falciparum was more frequent in symptomatic individuals (96.77% vs. 93.24%, p = 0.014). In contrast, P. malariae was more frequent in asymptomatic individuals (5.64% vs. 2.45%, p < 0.001). P. ovale remained the least frequent species (less than 1%), and no P. vivax was detected. The most frequent coinfections were P. falciparum and P. malariae (0.56%). Children aged 5–9 presented the highest frequency of P. falciparum infections (41.91%). Non-falciparum species were primarily detected in adolescents (10–14 years) with frequencies above 50%. Only P. falciparum infections had parasitemias greater than 100,000 parasites per µL of blood. P. falciparum gametocytes were found with variable prevalence across age groups. Our data highlight that P. falciparum represented the first burden, but other non-falciparum species were also important. Increasing attention to P. malariae and P. ovale is essential if malaria elimination is to be achieved.
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- 2023
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79. Nursing applicants' reasoning skills and factors related to them: A cross-sectional study
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Vierula, Jonna, Hupli, Maija, Engblom, Janne, Laakkonen, Eero, Talman, Kirsi, and Haavisto, Elina
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- 2021
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80. Mesenchymal stem cell therapy of acute thermal burns: A systematic review of the effect on inflammation and wound healing
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Rangatchew, Filip, Vester-Glowinski, Peter, Rasmussen, Bo Sonnich, Haastrup, Eva, Munthe-Fog, Lea, Talman, Maj-Lis, Bonde, Christian, Drzewiecki, Krzysztof T., Fischer-Nielsen, Anne, and Holmgaard, Rikke
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- 2021
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81. Frequency Domain Storage Ring Method for Electric Dipole Moment Measurement
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Talman, Richard
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Physics - Accelerator Physics - Abstract
Precise measurement of the electric dipole moments (EDM) of fundamental charged particles would provide a significant probe of physics beyond the standard model. Any measurably large EDM would imply violation of both time reversal and parity conservation, with implications for the matter/anti-matter imbalance of the universe, not currently understood within the standard model. A frequency domain (i.e. difference of frequencies) method is proposed for measuring the EDM of electrons or protons or, with modifications, deuterons. Anticipated precision (i.e. reproducibility) is $10^{-30}\,$e-cm for the proton EDM, with comparable accuracy (i.e. including systematic error). This would be almost six orders of magnitude smaller than the present upper limit, and will provide a stringent test of the standard model. Resonant polarimetry, made practical by the large polarized beam charge, is the key (most novel, least proven) element of the method. Along with the phase-locked, rolling polarization "Koop spin wheel," resonant polarimetry measures beam polarization as amplitude rather than as intensity. The polarization roll, at 100\,Hz for example, and adjustable by a constant control current, causes spurious torques due to field errors to average to zero to high accuracy. Since these torques have been considered to be the dominant source of systematic error in truly frozen spin operation, this is a major improvement resulting from the rolling polarization. Important sources of systematic errors remain, the main one being due to Wien filter reversal uncertainty. Both electron and proton spins can be "frozen" in all-electric storage rings, and their EDM precisions should be comparable. Freezing the deuteron spin requires a superimposed electric and magnetic guide field; otherwise the rolling spin method and precision should be similar., Comment: Errror identified and acknowledged in Section V B. A new "workaround" citation is given in the same section
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- 2015
82. Signs of universality in the structure of culture
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Băbeanu, Alexandru-Ionuţ, Talman, Leandros, and Garlaschelli, Diego
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Physics - Physics and Society ,Computer Science - Computers and Society ,Physics - Data Analysis, Statistics and Probability - Abstract
Understanding the dynamics of opinions, preferences and of culture as whole requires more use of empirical data than has been done so far. It is clear that an important role in driving this dynamics is played by social influence, which is the essential ingredient of many quantitative models. Such models require that all traits are fixed when specifying the "initial cultural state". Typically, this initial state is randomly generated, from a uniform distribution over the set of possible combinations of traits. However, recent work has shown that the outcome of social influence dynamics strongly depends on the nature of the initial state. If the latter is sampled from empirical data instead of being generated in a uniformly random way, a higher level of cultural diversity is found after long-term dynamics, for the same level of propensity towards collective behavior in the short-term. Moreover, if the initial state is randomized by shuffling the empirical traits among people, the level of long-term cultural diversity is in-between those obtained for the empirical and uniformly random counterparts. The current study repeats the analysis for multiple empirical data sets, showing that the results are remarkably similar, although the matrix of correlations between cultural variables clearly differs across data sets. This points towards robust structural properties inherent in empirical cultural states, possibly due to universal laws governing the dynamics of culture in the real world. The results also suggest that this dynamics might be characterized by criticality and involve mechanisms beyond social influence., Comment: 16 pages, 7 figures; the same results as in version 3, but a shorter Introduction, Discussion and Conclusion
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- 2015
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83. Scaling Behavior of Circular Colliders Dominated by Synchrotron Radiation
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Talman, Richard
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Physics - Accelerator Physics - Abstract
The quite low Higgs particle mass makes it natural for the next high energy facility to be a circular e+e- Higgs factory and, after that, a next-generation p,p collider in the same tunnel. Surveying the luminosity-limiting phenomena of synchrotron radiation power loss, beam-beam interaction limitations, and beamstrahlung, scaling laws are established that fix all parameters of the Higgs factory, as functions of assumed radius $r$, and RF power $P$. at least to a first approximation. Historically the accelerator formalisms of electron and hadron rings have been distinguished largely by the importance of synchrotron radiation for electrons, and its unimportance for protons. While electron beams equilibrate within seconds, proton beam distributions have survived largely intact for extended periods. For future hadron colliders, this distinction will no longer be valid. This will have a large impact on the design of the future FCC-pp proton collider whose parameters can be extrapolated using formulas previously applicable only to electron rings. The most important scaling law has the luminosity depending on $r$ and $P_{\rm rf}$ only as a function of their product $rP$. This relation simplifies choosing a tunnel radius that is optimal for both Higgs factory and p,p collider while (almost) minimizing the initial cost---by increasing $r$ and decreasing $P$ proportionally, the tunnel circumference can be increased (as required for p,p) without significant increase in Higgs factory cost., Comment: 50 pages, 28 figures. White Paper at the IAS Program on the Future of High Energy Physics, Hong Kong, 2015
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- 2015
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84. New method for a continuous determination of the spin tune in storage rings and implications for precision experiments
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Eversmann, D., Hejny, V., Hinder, F., Kacharava, A., Pretz, J., Rathmann, F., Rosenthal, M., Trinkel, F., Andrianov, S., Augustyniak, W., Bagdasarian, Z., Bai, M., Bernreuther, W., Bertelli, S., Berz, M., Bsaisou, J., Chekmenev, S., Chiladze, D., Ciullo, G., Contalbrigo, M., de Vries, J., Dymov, S., Engels, R., Esser, F. M., Felden, O., Gaisser, M., Gebel, R., Glückler, H., Goldenbaum, F., Grigoryev, K., Grzonka, D., Guidoboni, G., Hanhart, C., Heberling, D., Hempelmann, N., Hetzel, J., Hipple, R., Hölscher, D., Ivanov, A., Kamerdzhiev, V., Kamys, B., Keshelashvili, I., Khoukaz, A., Koop, I., Krause, H-J., Krewald, S., Kulikov, A., Lehrach, A., Lenisa, P., Lomidze, N., Lorentz, B., Maanen, P., Macharashvili, G., Magiera, A., Maier, R., Makino, K., Marianski, B., Mchedlishvili, D., Meißner, Ulf-G., Mey, S., Nass, A., Natour, G., Nikolaev, N., Nioradze, M., Nogga, A., Nowakowski, K., Pesce, A., Prasuhn, D., Ritman, J., Rudy, Z., Saleev, A., Semertzidis, Y., Senichev, Y., Shmakova, V., Silenko, A., Slim, J., Soltner, H., Stahl, A., Stassen, R., Statera, M., Stephenson, E., Stockhorst, H., Straatmann, H., Ströher, H., Tabidze, M., Talman, R., Engblom, P. Thörngren, Trzcinski, A., Uzikov, Yu., Valdau, Yu., Valetov, E., Vassiliev, A., Weidemann, C., Wilkin, C., Wirzba, A., Wronska, A., Wüstner, P., Zakrzewska, M., Zaplatin, E., Zupranski, P., and Zyuzin, D.
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Physics - Accelerator Physics ,Nuclear Experiment - Abstract
A new method to determine the spin tune is described and tested. In an ideal planar magnetic ring, the spin tune - defined as the number of spin precessions per turn - is given by $\nu_s = \gamma G$ (gamma is the Lorentz factor, $G$ the magnetic anomaly). For 970 MeV/c deuterons coherently precessing with a frequency of ~120 kHz in the Cooler Synchrotron COSY, the spin tune is deduced from the up-down asymmetry of deuteron carbon scattering. In a time interval of 2.6 s, the spin tune was determined with a precision of the order $10^{-8}$, and to $1 \cdot 10^{-10}$ for a continuous 100 s accelerator cycle. This renders the presented method a new precision tool for accelerator physics: controlling the spin motion of particles to high precision is mandatory, in particular, for the measurement of electric dipole moments of charged particles in a storage ring., Comment: 6 pages, 6 figures
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- 2015
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85. The Assessment of Learning Skills in Nursing Student Selection: A Scoping Review
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Vierula, Jonna, Haavisto, Elina, Hupli, Maija, and Talman, Kirsi
- Abstract
Higher education student selection has significant societal, institutional and individual impacts. Thousands of applicants apply only for nursing, one of the major higher education disciplines. As the nursing profession is characterised by cognitive requirements, higher education institutions assess the learning skills of nursing applicants. However, there has been no comprehensive analysis of learning skills assessment for nursing student selection. The purpose of this scoping review was to describe the assessment of learning skills in undergraduate nursing student selection. Five databases were systematically searched, and 24 studies published between 2006 and 2016 were included. Learning skills were most commonly assessed using standardised tests in the areas of language and communication, reasoning, mathematics and natural sciences. Overall scores of onsite selection methods were found to best predict future academic performance. The results indicate that higher education institutions may benefit from comprehensive assessment of learning skills in their selection processes. This assessment should focus on a wider range of cognitive aptitudes, including reasoning skills. This review focussed on nursing education, but the results may benefit other higher education disciplines due to the generic nature of learning skills and similar cognitive requirements of higher education studies. The results support the development of more comprehensive and valid methods for assessing learning skills.
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- 2020
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86. It is supposed to be a home
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Svanelöv, Eric, primary and Talman, Lena, additional
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- 2021
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87. The average tree value for hypergraph games.
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Liying Kang, Anna B. Khmelnitskaya, Erfang Shan, Dolf Talman, and Guang Zhang
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- 2021
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88. A Simulation-Based Study on Securing Data Sharing for Situational Awareness in a Port Accident Case.
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Latvakoski, Juhani, Umer, Adil, Nykänen, Topias, Tihinen, Jyrki, and Talman, Aleksi
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SITUATIONAL awareness ,DIGITAL twins ,INFORMATION sharing ,SECURITY sector ,TRUST - Abstract
The cyber–physical systems (CPSs) of various stakeholders from the mobility, logistics, and security sectors are needed to enable smart and secure situational awareness operations in a port environment. The motivation for this research arises from the challenges caused by some unexpected events, such as accidents, in such a multi-stakeholder critical environment. Due to the scale, complexity, and cost and safety challenges, a simulation-based approach was selected as the basis for the study. Prototype-level experimental solutions for dataspaces for secure data sharing and visualization of situational awareness were developed. The secure data-sharing solution relies on the application of verifiable credentials (VCs) to ensure that data consumers have the required access rights to the data/information shared by the data prosumer. A 3D virtual digital twin model is applied for visualizing situational awareness for people in the port. The solutions were evaluated in a simulation-based execution of an accident scenario where a forklift catches fire while loading a docked ship in a port environment. The simulation-based approach and the provided solutions proved to be practical and enabled the smooth study of disaster-type situations. The realized concept of dataspaces is successfully applied here for both daily routine operations and information sharing during accidents in the simulation-based environment. During the evaluation, needs for future research related to perception, comprehension, projection, trust, and security as well as performance and quality of experience were detected. Especially, distributed and secure viewpoints of objects and stakeholders toward real-time situational awareness seem to require further studies. [ABSTRACT FROM AUTHOR]
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- 2024
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89. Applicants' success in the ethics entrance exam: A cross-sectional study.
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Vierula, Jonna, Karihtala, Tiina, Ervaala, Niina, Naamanka, Kati, Haavisto, Elina, and Talman, Kirsi
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CROSS-sectional method ,DATA analysis ,RESEARCH funding ,ORGANIZATIONAL ethics ,UNIVERSITIES & colleges ,LOGISTIC regression analysis ,EDUCATIONAL tests & measurements ,DESCRIPTIVE statistics ,ACADEMIC achievement ,STATISTICS ,DATA analysis software - Abstract
Background: Student selection is the first step in recruiting future social and healthcare professionals. Ethically competent professionals are needed in social and healthcare. It is important to select applicants who have the best possible abilities to develop their ethical competence in the future. Values-based recruitment has been used to inform the recruitment and selection of higher education applicants. However, objective and valid tests in student selection are needed. Aim: To assess social and healthcare applicants' success and related factors in the ethics section of the universities of applied sciences digital entrance examination (UAS Exam) to undergraduate degree programmes. Research design: A cross-sectional design was used. Participants and research context: Social and healthcare applicants needed to identify ethical situations in the ethics section of a national digital entrance examination (UAS Exam) in autumn 2019 (between 29 October and 1 November) in 20 Finnish universities of applied sciences. Ethical considerations: The process for the responsible conduct of research was followed in the study. Ethics committee approval was obtained from the Human Sciences Ethics Committee in the Satakunta region (27 September 2019). Approval to undertake the study was obtained from the participating universities of applied sciences. Participation to the study was voluntary and based on informed consent. Results: The applicants' (n = 8971) mean scores were 7.1/20 (standard deviation 6.5), and 22.7% of the applicants failed the ethics section. Age, previous education, and place of birth (own/parent) explained the applicants' success in the ethics section (total score and failed exam results). Conclusion(s): Applicants' success in the ethics section varied indicating that future students may have a different basis to develop their ethical competence. This may impact on (new) students' learning, especially in practical studies. [ABSTRACT FROM AUTHOR]
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- 2024
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90. Emotional intelligence of nursing applicants and factors related to it: A cross-sectional study
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Talman, Kirsi, Hupli, Maija, Rankin, Robert, Engblom, Janne, and Haavisto, Elina
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- 2020
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91. Improving clinical trial outcomes in amyotrophic lateral sclerosis
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Kiernan, Matthew C., Vucic, Steve, Talbot, Kevin, McDermott, Christopher J., Hardiman, Orla, Shefner, Jeremy M., Al-Chalabi, Ammar, Huynh, William, Cudkowicz, Merit, Talman, Paul, Van den Berg, Leonard H., Dharmadasa, Thanuja, Wicks, Paul, Reilly, Claire, and Turner, Martin R.
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- 2021
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92. Measuring the Polarization of a Rapidly Precessing Deuteron Beam
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Bagdasarian, Z., Bertelli, S., Chiladze, D., Ciullo, G., Dietrich, J., Dymov, S., Eversmann, D., Fanourakis, G., Gaisser, M., Gebel, R., Gou, B., Guidoboni, G., Hejny, V., Kacharava, A., Kamerdzhiev, V., Lehrach, A., Lenisa, P., Lorentz, B., Magallanes, L., Maier, R., Mchedlishvili, D., Morse, W. M., Nass, A., Oellers, D., Pesce, A., Prasuhn, D., Pretz, J., Rathmann, F., Shmakova, V., Semertzidis, Y. K., Stephenson, E. J., Stockhorst, H., Ströher, H., Talman, R., Engblom, P. Thörngren, Valdau, Yu., Weidemann, C., and Wüstner, P.
- Subjects
Physics - Accelerator Physics - Abstract
This paper describes a time-marking system that enables a measurement of the in-plane (horizontal) polarization of a 0.97-GeV/c deuteron beam circulating in the Cooler Synchrotron (COSY) at the Forschungszentrum J\"ulich. The clock time of each polarimeter event is used to unfold the 120-kHz spin precession and assign events to bins according to the direction of the horizontal polarization. After accumulation for one or more seconds, the down-up scattering asymmetry can be calculated for each direction and matched to a sinusoidal function whose magnitude is proportional to the horizontal polarization. This requires prior knowledge of the spin tune or polarization precession rate. An initial estimate is refined by re-sorting the events as the spin tune is adjusted across a narrow range and searching for the maximum polarization magnitude. The result is biased toward polarization values that are too large, in part because of statistical fluctuations but also because sinusoidal fits to even random data will produce sizeable magnitudes when the phase is left free to vary. An analysis procedure is described that matches the time dependence of the horizontal polarization to templates based on emittance-driven polarization loss while correcting for the positive bias. This information will be used to study ways to extend the horizontal polarization lifetime by correcting spin tune spread using ring sextupole fields and thereby to support the feasibility of searching for an intrinsic electric dipole moment using polarized beams in a storage ring. This paper is a combined effort of the Storage Ring EDM Collaboration and the JEDI Collaboration., Comment: 28 pages, 15 figures, prepared for Physical Review ST - Accelerators and Beams
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- 2014
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93. The Malaria Cell Atlas : Single parasite transcriptomes across the complete Plasmodium life cycle
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Howick, Virginia M., Russell, Andrew J. C., Andrews, Tallulah, Heaton, Haynes, Reid, Adam J., Natarajan, Kedar, Butungi, Hellen, Metcalf, Tom, Verzier, Lisa H., Rayner, Julian C., Berriman, Matthew, Herren, Jeremy K., Billker, Oliver, Hemberg, Martin, Talman, Arthur M., and Lawniczak, Mara K. N.
- Published
- 2019
94. Skill Retention After Completion of a Proficiency- Based Curriculum to Teach Cricothyroidotomy
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Grangeia, Laura, Streich, Heather, Stone, Justin, Talman, Erin, and Sudhir, Amita
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- 2016
95. ELOQUENT 2024 - Robustness Task
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Sahlgren, Magnus, Karlgren, Jussi, Dürlich, Luise, Gogoulou, Evangelia, Talman, Aarne, Zahra, Shorouq, Sahlgren, Magnus, Karlgren, Jussi, Dürlich, Luise, Gogoulou, Evangelia, Talman, Aarne, and Zahra, Shorouq
- Abstract
ELOQUENT is a set of shared tasks for evaluating the quality and usefulness of generative language models. ELOQUENT aims to apply high-level quality criteria, grounded in experiences from deploying models in real-life tasks, and to formulate tests for those criteria, preferably implemented to require minimal human assessment effort and in a multilingual setting. One of the tasks for the first year of ELOQUENT was the robustness task, in which we assessed the robustness and consistency of a model output given variation in the input prompts. We found that indeed the consistency varied, both across prompt items and across models, and on a methodological note we find that using a oracle model for assessing the submitted responses is feasible, and intend to investigate consistency across such assessments for different oracle models. We intend to run this task in coming editions for ELOQUENT to establish a solid methodology for further assessing consistency, which we believe to be a crucial component of trustworthiness as a top level quality characteristic of generative language models., This lab has been supported by the European Commission through the DeployAI project (grant number 101146490), by the Swedish Research Council (grant number 2022-02909), and by UK Research and Innovation (UKRI) under the UK government's Horizon Europe funding guarantee [grant number 10039436 (Utter)].
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- 2024
96. Overview of the “Voight-Kampff” Generative AI Authorship Verification Task at PAN and ELOQUENT 2024
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Bevendorff, Janek, Wiegmann, Matti, Karlgren, Jussi, Dürlich, Luise, Gogoulou, Evangelia, Talman, Aarne, Stamatatos, Efstathios, Potthast, Martin, Stein, Benno, Bevendorff, Janek, Wiegmann, Matti, Karlgren, Jussi, Dürlich, Luise, Gogoulou, Evangelia, Talman, Aarne, Stamatatos, Efstathios, Potthast, Martin, and Stein, Benno
- Abstract
The “Voight-Kampff” Generative AI Authorship Verification task aims to determine whether a text was generated by an AI or written by a human. As in its fictional inspiration,1 the Voight-Kampff task structures AI detection as a builder-breaker challenge: The builders, participants in the PAN lab, submit software to detect AI-written text and the breakers, participants in the ELOQUENT lab, submit AI-written text with the goal of fooling the builders. We formulate the task in a way that is reminiscent of a traditional authorship verification problem, where given a pair of texts, their human or machine authorship is to be inferred. For this first task installment, we further restrict the problem so that each pair is guaranteed to contain one human and one machine text. Hence the task description reads: Given two texts, one authored by a human, one by a machine: pick out the human. In total, we evaluated 43 detection systems (30 participant submissions and 13 baselines), ranging from linear classifiers to perplexity-based zero-shot systems. We tested them on 70 individual test set variants organized in 14 base collections, each designed on different constraints such as short texts, Unicode obfuscations, or language switching. The top systems achieve very high scores, proving themselves not perfect but sufficiently robust across a wide range of specialized testing regimes. Code used for creating the datasets and evaluating the systems, baselines, and data are available on GitHub., The “Voight-Kampff” Generative AI Authorship Detection Task @ PAN 2024 has been funded as part ofthe OpenWebSearch project by the European Commission (OpenWebSearch.eu, GA 101070014).
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- 2024
97. Molecular subtyping improves breast cancer diagnosis in the Copenhagen Breast Cancer Genomics Study
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Berg, Tobias, Jensen, Maj Britt, Celik, Alan, Talman, Maj Lis, Misiakou, Maria Anna, Knoop, Ann Søegaard, Nielsen, Finn Cilius, Ejlertsen, Bent, Rossing, Maria, Berg, Tobias, Jensen, Maj Britt, Celik, Alan, Talman, Maj Lis, Misiakou, Maria Anna, Knoop, Ann Søegaard, Nielsen, Finn Cilius, Ejlertsen, Bent, and Rossing, Maria
- Abstract
BACKGROUND. Intrinsic molecular subtypes define distinct biological breast cancers and can be used to further improve diagnosis and risk allocation. METHODS. The Copenhagen Breast Cancer Genomics Study (CBCGS) prospectively included women diagnosed with breast cancer at Rigshospitalet from 2014 to 2021. Eligible patients were females with a primary invasive breast cancer (T1c, if N0M0; otherwise, any T, any N, or any M stage) and no prior malignancy. All patients underwent molecular profiling with the CIT256 and PAM50 molecular profile. RESULTS. In the study period, 2,816 patients were included in the CBCGS. Molecular subtyping showed an increase in nonluminal (molecular-apocrine, luminal C, and Basal-like) as compared with luminal (luminal A, luminal B, and Normal-like) subtypes with increasing stage from I to IV. Across all stages, we found a significant difference in survival among subtypes; 91% of patients with LumA were alive at 5 years compared with 91% for LumB, 84% for LumC, 82% for mApo, and 80% for Basal-like. We identified 442 tumors (16%) that were discordant in subtype between CIT256 and IHC. Discordant subtype proved to be a risk factor of death among patients with IHC luminal breast cancer (hazard ratio [HR], 2.08; 95% CI, 1.51–2.86) in a multivariable Cox regression analysis. Discordance occurred more often among patients with N3, stage IV, or grade III disease. CONCLUSION. Our findings indicate that molecular subtypes are a predominant classification for survival. Assessment is particularly crucial for patients with IHC luminal breast cancer with known high-risk factors, since they are at an increased risk of harboring an aggressive molecular subtype., BACKGROUND. Intrinsic molecular subtypes define distinct biological breast cancers and can be used to further improve diagnosis and risk allocation. METHODS. The Copenhagen Breast Cancer Genomics Study (CBCGS) prospectively included women diagnosed with breast cancer at Rigshospitalet from 2014 to 2021. Eligible patients were females with a primary invasive breast cancer (T1c, if N0M0; otherwise, any T, any N, or any M stage) and no prior malignancy. All patients underwent molecular profiling with the CIT256 and PAM50 molecular profile. RESULTS. In the study period, 2,816 patients were included in the CBCGS. Molecular subtyping showed an increase in nonluminal (molecular-apocrine, luminal C, and Basal-like) as compared with luminal (luminal A, luminal B, and Normal-like) subtypes with increasing stage from I to IV. Across all stages, we found a significant difference in survival among subtypes; 91% of patients with LumA were alive at 5 years compared with 91% for LumB, 84% for LumC, 82% for mApo, and 80% for Basal-like. We identified 442 tumors (16%) that were discordant in subtype between CIT256 and IHC. Discordant subtype proved to be a risk factor of death among patients with IHC luminal breast cancer (hazard ratio [HR], 2.08; 95% CI, 1.51–2.86) in a multivariable Cox regression analysis. Discordance occurred more often among patients with N3, stage IV, or grade III disease. CONCLUSION. Our findings indicate that molecular subtypes are a predominant classification for survival. Assessment is particularly crucial for patients with IHC luminal breast cancer with known high-risk factors, since they are at an increased risk of harboring an aggressive molecular subtype.
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- 2024
98. GATA4-targeted compound exhibits cardioprotective actions against doxorubicin-induced toxicity in vitro and in vivo: establishment of a chronic cardiotoxicity model using human iPSC-derived cardiomyocytes
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Karhu, S. Tuuli, Kinnunen, Sini M., Tölli, Marja, Välimäki, Mika J., Szabó, Zoltán, Talman, Virpi, and Ruskoaho, Heikki
- Published
- 2020
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99. Souporcell: robust clustering of single-cell RNA-seq data by genotype without reference genotypes
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Heaton, Haynes, Talman, Arthur M., Knights, Andrew, Imaz, Maria, Gaffney, Daniel J., Durbin, Richard, Hemberg, Martin, and Lawniczak, Mara K. N.
- Published
- 2020
- Full Text
- View/download PDF
100. The average covering tree value for directed graph games
- Author
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Khmelnitskaya, Anna, Selçuk, Özer, and Talman, Dolf
- Published
- 2020
- Full Text
- View/download PDF
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