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Human settlements are mainly formed by buildings with their different characteristics and usage. Despite the importance of buildings for the economy and society, complete regional or even national figures of the entire building stock and its spatial distribution are still hardly available. Available digital topographic data sets created by National Mapping Agencies or mapped voluntarily through a crowd via Volunteered Geographic Information (VGI) platforms (e.g. OpenStreetMap) contain building footprint information but often lack additional information on building type, usage, age or number of floors. For this reason, predictive modeling is becoming increasingly important in this context. The capabilities of machine learning allow for the prediction of building types and other building characteristics and thus, the efficient classification and description of the entire building stock of cities and regions. However, such data-driven approaches always require a sufficient amount of ground truth (reference) information for training and validation. The collection of reference data is usually cost-intensive and time-consuming. Experiences from other disciplines have shown that crowdsourcing offers the possibility to support the process of obtaining ground truth data. Therefore, this paper presents the results of an experimental study aiming at assessing the accuracy of non-expert annotations on street view images collected from an internet crowd. The findings provide the basis for a future integration of a crowdsourcing component into the process of land use mapping, particularly the automatic building classification.

Implants often overtake body function just for a certain time and remain as an unnecessary foreign body or have to be removed. Thus, resorbable implants are highly beneficial to reduce patient burden. Besides established materials, Iron-(Fe)-based alloys are in focus due to superior mechanical properties and good biocompatibility. However, their degradation rate needs to be increased. Phases with high electrochemical potential could promote the dissolution of residual material based on the galvanic coupling. Silver (Ag) is promising due to its high electrochemical potential (+0.8 V vs. SHE), immiscibility with Fe, biocompatibility, and anti-bacterial properties. But to prevent adverse consequences the Ag-particles, remaining after dissolution of the matrix, need to dissolve. Thus, a bioresorbable Ag-alloy is required. Regarding the electrochemical potential and degradation behavior of binary alloys, Cerium (Ce) and Lanthanum (La) are well-suited considering their biocompatibility and antibacterial behavior. Accordingly, this research addresses AgCe and AgCeLa alloys as additives for Fe-based materials with adapted degradation behavior. Furthermore, degradable Ag-alloys combined with inert implant materials could enable the controlled release of antibacterial active Ag-ions.

A large share of urban land is dedicated to commercial and industrial activities. While this is considered key for economic development, the contribution of such areas to urban expansion has also been strongly criticised from environmental and societal perspectives. Clearly, the interrelations between economic activity and land use are highly relevant to planning and policy development. Yet relatively little is known about patterns of commercial and industrial land at the level of city regions and their effect on economic development. The goal of this contribution is to present an empirical approach for analysing the development of commercial and industrial land within city regions and to place this in a socio-economic context. We argue that land provision at suitable (i.e. central) locations has a positive effect on employment. To test this hypothesis, we investigate relevant land use changes by analysing processed topographic land use data and location by centrality in regional road networks, using the example of city regions in southern Germany for the period 2006–2018. Our results reveal regional patterns of distinct spatial and socio-economic trends that indicate suburbanisation processes and the emergence of polycentric patterns. While employed is closely correlated with absolute change in land in both large and small regions, the correlation between location and employment decreases with the size of regions. The results confirm the viability of the chosen approach to illuminate processes within functionally-interlinked city regions and promote a discussion of cause-effect relationships between the provision of commercial/industrial areas and employment.

OBJECTIVES Preventing type A aortic dissection requires reliable prediction. We developed and validated a multivariable prediction model based on anthropometry to define patient-adjusted thresholds for aortic diameter and length. METHODS We analysed computed tomography angiographies and clinical data from 510 control patients, 143 subjects for model validation, 125 individuals with ascending aorta ectasia (45–54 mm), 58 patients with aneurysm (≥55 mm), 206 patients with type A aortic dissection and 19 patients who had received a computed tomography angiography ≤2 years before they suffered from a type A aortic dissection. Computed tomography angiographies were analysed using curved planar reformations. RESULTS In the control group, the mean ascending aortic diameter was 33.8 mm [standard deviation (SD) ±5.2 mm], and the length, measured from the aortic valve to the brachiocephalic trunk, was 91.9 mm (SD ±12.2 mm); both diameter and length were correlated with anthropometric parameters and were smaller than the respective values in all pathological groups (P 25% in the ectasia and aneurysm groups. CONCLUSIONS The regression model provides a patient-adjusted prediction of the thresholds for aortic diameter and length. In our retrospective data, the model resulted in better identification of aortas at the risk of dissection than the conventional 55-mm diameter threshold. The model is available as an Internet calculator (www.aorticcalculator.com).

Im Dezember 2015 traten die Gesellschafter Dr. Michael und Benjamin Otto sowie die sieben damaligen Vorstande der Otto Group auf einer Veranstaltung in der Hamburger Konzernzentrale vor mehreren hundert Mitarbeitern. Sie stiesen dort einen Prozess an, der die tief greifendste Veranderung in der 70-jahrigen Unternehmensgeschichte werden sollte: Den Kulturwandel 4.0. Dieser fordert und fordert das Umdenken bisheriger Denk- und Verhaltensweisen aller Mitarbeiterinnen und Mitarbeiter, um die (Zusammen-)arbeit im Konzern nachhaltig zu verandern. Und er erfordert Kraft, um alle Unsicherheiten und Herausforderungen, die im Prozess unweigerlich verankert sind, auszuhalten. In diesem Beitrag werden die Herangehensweise an einen solchen umfassenden Veranderungsprozess und dazugehorige Herausforderungen beschrieben, sowie erste Best Practices und Erkenntnisse hinsichtlich moglicher Erfolgsfaktoren skizziert.

Formylglycine‐generating enzymes specifically oxidize cysteine within the consensus sequence CxPxR to Cα‐formylglycine (FGly). This noncanonical electrophilic amino acid can subsequently be addressed selectively by bioorthogonal hydrazino‐iso‐Pictet‐Spengler (HIPS) or Knoevenagel ligation to attach payloads like fluorophores or drugs to proteins to obtain a defined payload‐to‐protein ratio. However, the disadvantages of these conjugation techniques include the need for a large excess of conjugation building block, comparably low reaction rates and limited stability of FGly‐containing proteins. Therefore, functionalized clickable HIPS and tandem Knoevenagel building blocks were synthesized, conjugated to small proteins (DARPins) and subsequently linked to strained alkyne‐containing payloads for protein labeling. This procedure allowed the selective bioconjugation of one or two DBCO‐carrying payloads with nearly stoichiometric amounts at low concentrations. Furthermore, an azide‐modified tandem Knoevenagel building block enabled the synthesis of branched PEG linkers and the conjugation of two fluorophores, resulting in an improved signal‐to‐noise ratio in live‐cell fluorescence‐imaging experiments targeting the EGF receptor., Increased efficiency: The combination of azide‐functionalized HIPS or tandem Knoevenagel ligation reagents and SPAAC enables the fast and efficient mono‐ and double‐derivatization of proteins with stoichiometric amounts of DBCO‐modified payloads at low concentration.

OBJECTIVES There is an ongoing discussion about how to treat coronary stents during bypass surgery: Should patent stents be left alone and the stented vessels be ungrafted, or should every stented coronary artery receive a bypass graft? This study aims to determine the relevance of perioperative stent stenosis or occlusion on postoperative outcomes up to 3 years postoperatively. METHODS Patients undergoing coronary artery bypass grafting surgery (CABG) (±concomitant procedures) with previous percutaneous coronary intervention from 4 centres were prospectively included in this observatory study between April 2015 and June 2017. A coronary angiography was conducted between the fifth and seventh postoperative days. The preoperative and postoperative angiograms were assessed in a core laboratory, assessing the patencies of coronary stents and bypass grafts. The core lab investigators were blinded to the patients’ characteristics and perioperative course. RESULTS A total of 107 patients were included in the study. In the postoperative coronary angiography, 265 bypass grafts and 189 coronary stents were examined angiographically. Ninety-seven percent of preoperatively patent stents remained patent. New coronary stent stenoses were observed in 5 patients (4.7%). All 5 patients were asymptomatic and managed conservatively. Bypass stenoses were observed in 12 patients (11%), of whom were managed conservatively, 4 underwent percutaneous coronary intervention and 1 underwent redo-CABG. Two years postoperatively, 97% of patients were alive. Patients with new stent stenosis tended to have a better survival compared with patients with bypass stenosis (100% vs 73%; P = 0.09) up to 3 years postoperatively. CONCLUSIONS Perioperative coronary stent stenosis occurs rarely. It is safe to leave a patently stented coronary vessel without bypass grafting.

Resorbable implants are highly beneficial to reduce patient burden since they need not be removed after a defined period. Currently, magnesium (Mg) and polymers are being applied as bioresorbable materials. However, for some applications the insufficient mechanical properties and high degradation rate of Mg cause the need for new materials. Iron (Fe)-based alloys are promising due to their biocompatibility and good mechanical properties, but their degradation rate is too low and needs to be adapted eg. via alloying with manganese (Mn). Besides, phases with high electrochemical potential lead to increased degradation of residual material with lower potential based on the galvanic coupling. Here, silver (Ag) is promising for the formation of such phases due to its high electrochemical potential (+0.8 V vs. SHE), immiscibility with Fe, biocompatibility, and anti-bacterial properties. Since remaining silver particles can lead to adverse consequences as thrombosis, these particles need to dissolve after the matrix material. Thus a silver alloy with high electrochemical potential, biocompatibility, and adjusted degradation behavior is required as an additive for iron-based bioresorbable materials. Several silver alloying systems are possible, but regarding the electrochemical potential and degradation behavior of binary alloys, calcium (Ca) and lanthanum (La) are best-suited considering their biocompatibility. Accordingly, this research addresses AgCa and AgCaLa alloys as additives for iron-based degradable materials with adapted degradation behavior

OBJECTIVES We measured aortic dimensions, particularly length parameters, using 3D imaging with the aim of refining the risk-morphology for Stanford type A aortic dissection (TAD). METHODS Computer tomography angiography studies were analysed using the curved multiplanar reformats. At defined landmarks, the diameters and lengths of aortic segments were recorded. Three groups were compared retrospectively: patients actually suffering from a TAD (TAD-group; n = 150), patients before suffering a TAD (preTAD-group n = 15) and a healthy control group ( n = 215). Receiver operating characteristic curves (ROCs) were analysed (control versus preTAD) to study the diagnostic value of the individual variables. RESULTS Median diameters of preTAD (43 mm) and TAD (50 mm) aortas were significantly ( P

The catheter-based Impella 5.0 left ventricular assist device is a powerful and less invasive alternative for patients in cardiogenic shock. The use as second-line therapy in patients with precedent extracorporeal life support (ECLS) has not been described before now. We analyzed our experience of consecutive patients treated with this alternative strategy. From April 2014 to December 2014, eight patients had been implanted as a second-line option after ECLS support. The reason for the change from ECLS to Impella 5.0 was absence of cardiac recovery for primary weaning and complications of ECLS therapy. The mean time of ECLS support prior to Impella implantation was 12 ± 7 days. The implantation of the Impella 5.0/CP was technically successful in all patients, and the ECLS could be explanted in all eight patients who received Impella implantation as a second-line treatment. The second-line Impella 5.0 therapy resulted in two patients who turned into left ventricular assist device (LVAD) candidates, two primary weaning candidates, and four patients who died in the setting of sepsis or absent cardiac recovery and contraindications for durable LVAD therapy. Thereby, the overall hospital discharge survival as well as the 180-day survival was 50% for Impella 5.0 implantations as second-line procedure after ECLS. The latest follow-up survival of this second-line strategy after ECLS was three out of eight, as one patient died after 299 days of LVAD support due to sepsis. The use of Impella 5.0 constitutes a possible second-line therapeutic option for those patients who do not show cardiac recovery during prolonged ECLS support or suffer from complications of ECLS therapy. This treatment allows additional time for decisions regarding cardiac recovery or indication for durable LVAD therapy.

Background Emergency coronary artery bypass grafting (CABG) in the setting of acute coronary syndrome (ACS) has been associated with increased morbidity and mortality. Avoiding cardiopulmonary bypass might be advantageous, but the role of off-pump CABG (OPCAB) remains controversial, as it has been associated with incomplete revascularization in several studies. The objective of this study was to evaluate the feasibility, efficacy, and outcome of OPCAB surgery in ACS patients. Methods We performed a retrospective review of ACS patients who underwent on-pump CABG (ONCAB) or OPCAB, either emergently or delayed, at our institution. Results Between January 2015 and December 2016, a total of 205 consecutive ACS patients underwent either ONCAB (109 patients, 53.2%) or OPCAB surgery (96 patients, 46.8%). EuroSCORE II levels (5.6 ± 7.2 vs 4.9 ± 6.5, p = 0.226) and demography were comparable between groups.A trend towards lower postoperative mortality was observed in OPCAB patients (2.1 vs 5.5%). The incidence of postoperative stroke and low cardiac output syndrome, as well as the duration of inotropic support and the need for re-sternotomy, was significantly lower in the OPCAB group (p CABG performed instantly in an emergency situation was not associated with increased mortality or morbidity when compared with delayed procedures, and OPCAB surgery in emergency patients was associated with lower postoperative morbidity and shorter stays in the intensive care unit (p There were no differences in completeness of revascularization between groups (median 1 [1–1.33;0.33–1.67] OPCAB versus median 1 (1–1.33;0.67–2) ONCAB, p = 0.617), even in the emergency setting. Conclusion OPCAB surgery is safe and effective in ACS and may be considered in hemodynamically stable patients in the emergency setting.

Formylglycine-generating enzymes provide a convenient tool for site-specific protein derivatization. Their ability to oxidize cysteine or serine residues within a defined consensus sequence to C-alpha-formylglycine (FGly) allows for the targeted introduction of a unique chemical handle for various bioconjugation reactions. In recent years, oxygen-dependent FGly-generating enzyme saw broad use in protein functionalization and the generation of protein conjugates. Yet, the FGly-generating system AtsB, along with its capability to convert unusual aldehyde tag sequences, remains mostly unused. Herein, the ability of AtsB from Methanosarcina mazei to convert nonclassical aldehyde tags of the SX(A/P)XR-type and its potential use in bioconjugation chemistry are demonstrated.

Site-specific bioconjugation strategies offer many possibilities for directed protein modifications. Among the various enzyme-based conjugation protocols, formylglycine-generating enzymes allow to posttranslationally introduce the amino acid Cα-formylglycine (FGly) into recombinant proteins, starting from cysteine or serine residues within distinct consensus motifs. The aldehyde-bearing FGly-residue displays orthogonal reactivity to all other natural amino acids and can, therefore, be used for site-specific labeling reactions on protein scaffolds. In this review, the state of research on catalytic mechanisms and consensus motifs of different formylglycine-generating enzymes, as well as labeling strategies and applications of FGly-based bioconjugations are presented.

Urban green is indispensable from an urban ecological and social point of view and fulfils important functions such as dust binding, temperature reduction, wind damping or groundwater recharge. Especially for bioclimatic modeling, knowledge of size, structure and green volume of the urban vegetation is essential. Manual mapping of vegetation structures is timeconsuming and cost-intensive and can only ever be carried out in locally limited study areas. Active and passive remote sensing technologies in combination with automated methods for information extraction offer the opportunity to record the green structure in urban areas differentiated according to vegetation types. The new globally and freely available data provided by the European Copernicus Program raises the question whether these data are suitable for mapping and quantifying the urban green structure, including an accuracy estimation. Previous studies on the usability of Sentinel-2 data for vegetation analysis were essentially limited to crop and tree species classification in open space. The approach presented here thus considers for the first time the application of this data in a purely urban environment. Here we present a modeling approach based on multiple regression models. A Sentinel-2A scene from July 4, 2015 covering the greater Dresden area served as the input data set. After atmospheric correction of the satellite image scene 10 spectral channels were available. A high-resolution vegetation cover model with a grid width of 50 cm was available as a reference data set for the entire study area (City of Dresden, Germany). This takes into account the vegetation classes deciduous trees, conifers, shrubs, low (grassy) vegetation and arable land. Thus the area share of these vegetation types could be determined aggregated for each pixel of the satellite image scene. In addition, vegetation indices (NDVI and others) were calculated using suitable channels. For the prediction of each vegetation class, estimation equations were drawn up and evaluated with regard to their quality. Especially for deciduous and coniferous trees, satisfactory model quality values could be obtained, so that the green component prediction in these cases represents a useful basis for the determination of the green structure at the building block level in urban areas.

Background Ascending aorta or hemi-arch repair are common in the acute phase of type A dissection. Postdissection aneurysms can develop with antegrade perfusion of the false lumen in the dissected aortic arch and require reoperation. Methods From 2012 to 2018, we reoperated nine patients with postdissection aneurysms using a hybrid technique without cardiopulmonary bypass. The patients had a EuroSCORE II of 13% and a logistic EuroSCORE I of 45% and were not candidates for frozen elephant trunk surgery. The median interval since the acute ascending repair was 184 (92; 528) days. All patients were treated by median resternotomy, ascending to carotid bypass on a partially clamped ascending graft, and transfemoral endovascular repair with a Relay NBS (nonbare stent) or conformable Gore C-TAG stent graft. Results Technical success was achieved in all cases. Mean follow-up was 405 (220; 672) days. There was no disabling stroke, endoleak, paraplegia, in-hospital, or late mortality. In all patients, the false lumen was completely thrombosed at the aortic arch level with a median aneurysm shrinkage of 13 mm in the distal arch. There was no bird beak or stent graft migration. Distal stent-induced new entry was observed in one case. Reinterventions were not necessary due to diameter stability. Conclusion Complete debranching with transfemoral thoracic endovascular aneurysm repair showed encouraging results in patients with relevant comorbidities. The used stent grafts performed well in the mid-term follow-up period with no endoleaks or migration.

To gain differential knowledge about the physiological compliance and wall strength of the different regions of the aorta, including the ascending aorta, arch and descending aorta in both the circumferential and longitudinal directions, and to generate a hypothesis on the pathophysiological mechanisms that lead to Type A aortic dissection.Fresh tissue specimens from 22 ex vivo porcine aortas were analysed on a tensile tester. Regional and directional compliance, failure stress and failure strain were recorded.Aortic compliance appeared as a linear function of the natural logarithm (ln) of wall stress. Compliance significantly decreased along the length of the aorta. In the ascending aorta, longitudinal compliance significantly (P = 0.003) exceeded circumferential compliance, and the outer curvature was more compliant than the inner curvature (P = 0.03). In the descending aorta, this relationship is reversed: the circumferential compliance exceeded the longitudinal compliance, and the outer aspect was more compliant (P = 0.003). The median circumferential failure stress of all aortic segments was in the range of 2000-2750 kPa, whereas the longitudinal failure stress in the ascending aorta and the arch had values of 750-1000 kPa, which were significantly lower (P < 0.05). Surprisingly, the longitudinal failure stress of the inner aspect of the descending aorta was extraordinarily high (2000 kPa). Failure strain, similar to compliance, was highest in the ascending aorta and decreased along the aorta.The aorta appears to be a complex organ with distinct regional and directional differences in compliance and wall strength that is designed to effectively absorb the kinetic energy of cardiac systole and to cushion the momentum of systolic impact. Under normotensive conditions and a preconditioned physiological morphology, the aortic wall works in the steep part of the logarithmic strain-stress function; under hypertensive conditions and pathological morphology, the wall reacts in an non-compliant manner. The high longitudinal compliance and low failure stress of the ascending aorta and subsequent pathological changes may be the main determinants of the recurrent patho-anatomy of Type A aortic dissection.

OBJECTIVES Unlike aneurysm formation, the role of ascending aortic elongation in the pathogenesis of Type A aortic dissection (TAD) is largely unclear. We investigated the morphology of healthy, dissected and predissection aortas with a focus on ascending aortic length. METHODS We retrospectively compared clinical and computer tomography angiography (CTA) data from TAD patients (n = 130), patients who developed a TAD in the further clinical course (preTAD, n = 16) and healthy control patients who received a CTA for non-aortic emergencies (n = 165). The length of the ascending aorta was defined as the distance between the sinotubular junction (STJ) and the brachiocephalic trunk (BCT) at the central line, the outer and inner curvature as well as the direct distance in the frontal and sagittal planes. Additionally, the aortic diameters were analysed. RESULTS In the healthy controls, we found a positive correlation of age with the aortic diameter (r = 0.57) and aortic length (r = 0.42). The correlation of the respective parameters with the body size was negligible (r < 0.2). The median ascending aortic diameter at the height of the pulmonary artery in TAD (50 mm) was significantly (P < 0.001) larger compared with the respective diameter of the healthy aortas (34 mm). The diameter of the preTAD aortas (40 mm) was also significantly larger compared with the healthy controls. These proportions were similar in all the aortic diameters. The midline length of the healthy ascending aortas was 71 mm. In the preTAD and TAD aortas, the same values were 81 mm and 92 mm, respectively (both P < 0.001). We evaluated the linear distance between the STJ and the BCT in the frontal plane as an easy-to-measure parameter of aortic length. In the TAD aortas (108 mm) and preTAD aortas (97 mm), this distance was significantly longer compared with the healthy aortas (84 mm). CONCLUSIONS Aortic diameter might not be an optimal parameter to predict dissection. Most aortas dissect at diameters below 55 mm. Both the TAD and preTAD aortas were elongated compared with the healthy controls. Thus, aortic elongation may play a role in the pathogenesis of and may be a risk factor for TAD.

The German Registry for Acute Aortic Dissection Type A (GERAADA) as an international registry for acute aortic dissection type A (AADA) offers a unique opportunity to answer questions regarding acute dissections that cannot be answered by single institution's database alone. GERAADA was started in 2006 by the German Society for Thoracic and Cardiovascular Surgery (GSTCVS) and has collected more than 3,300 AADA patients' data from 56 centers in Germany, Austria, and Switzerland up to now. In the second generated validated dataset comprising the years from 2006 to 2010, 2,137 patients were surgically treated for AADA with an overall 30-day mortality of 16.9%, and a new postoperative neurologic dysfunction of 9.5%. Risk factors for neurologic dysfunction were malperfusion syndromes, dissections of the supra-aortic vessels, and longer operating time. Neuroprotective drugs had no influence on stroke rates. Hypothermic circulatory arrest and antegrade selective cerebral perfusion (ACP) led to similar results if arrest times were less than 30 minutes while ACP for longer arrest periods is advisable. Septuagenarians had an early mortality rate (15.8%) similar to the whole cohort's, but the mortality rate in octogenarians (34.9%) was much higher. GERAADA with its validated 2,137 patient files (2006-2010) is the largest database on AADA worldwide and continues to collect data. Structured follow-up of more than 5 years will be available in the future.

Formylglycine-generating enzymes are of increasing interest in the field of bioconjugation chemistry. They catalyze the site-specific oxidation of a cysteine residue to the aldehyde-containing amino acid Cα -formylglycine (FGly). This non-canonical residue can be generated within any desired target protein and can subsequently be used for bioorthogonal conjugation reactions. The prototypic formylglycine-generating enzyme (FGE) and the iron-sulfur protein AtsB display slight variations in their recognition sequences. We designed specific tags in peptides and proteins that were selectively converted by the different enzymes. Combination of the different tag motifs within a single peptide or recombinant protein enabled the independent and consecutive introduction of two formylglycine residues and the generation of heterobifunctionalized protein conjugates.

Die steigende Zersiedelung hat gravierende langfristige Auswirkungen. Daher sollte Zersiedelung in der Stadt- und Regionalplanung kunftig vermieden werden. Dieses Kapitel klart die Definition von Zersiedelung und stellt eine Methode zur Messung der Zersiedelung vor (Z bzw. Weighted Urban Proliferation, WUP). Quantitative Angaben zur Zersiedelung werden dazu benotigt, um die Wirksamkeit von Masnahmen und Verordnungen zu uberprufen, die zur Begrenzung der Zersiedelung dienen sollen. Vier Beispiele illustrieren den Grad der Zersiedelung in Deutschland, in der Schweiz, in Europa und in zwei Stadtregionen aus Nordamerika (Montreal und Quebec City, im Vergleich mit Zurich). Die Messgrose Z kann beim Vergleich von Planungsalternativen eingesetzt werden: Planer und Entscheidungstrager konnen Zersiedelung kunftig vermeiden, indem sie verschiedene Planungsszenarien hinsichtlich ihres Beitrags zur Erhohung oder Verringerung der Zersiedelung vergleichen. Daten zum Grad der Zersiedelung sind auserdem nutzlich fur die Umweltbeobachtung und fur die Einfuhrung von Ziel- und Grenzwerten fur die Zersiedelung. Es ist zu erwarten, dass die Zersiedelung in Deutschland, in der Schweiz und in Europa generell weiter ansteigen wird. Daher lauft in der Schweiz derzeit die Volksinitiative „Zersiedelung stoppen – fur eine nachhaltige Siedlungsentwicklung“. Sie wurde am 21. Oktober 2016 bei der Bundeskanzlei eingereicht und wird demnachst zur Abstimmung kommen. Dieses Kapitel stellt abschliesend die Initiative vor, da sie Ausdruck eines steigenden Problembewusstseins in der Bevolkerung ist und Hoffnung gibt, das Problem der Zersiedelung kunftig besser zu vermeiden.

Die Umsetzung einer nachhaltigen Flachenpolitik erfordert ein Monitoring, welches nicht nur den jeweils aktuellen Stand der Nutzungsartenanteile an der Gesamtflache bilanziert, sondern auch den konkreten Wandel der Nutzungsarten hochauflosend beschreiben kann. Zum Prozessverstandnis und zur Beurteilung der Triebkrafte der Siedlungsentwicklung sind Aussagen zur Vor- und Nachnutzung von Flachen erforderlich. Vor diesem Hintergrund ist am Leibniz-Institut fur okologische Raumentwicklung (IOR) ein Verfahren entwickelt worden, mit dem Flachennutzungsanderungen unter Verwendung von aufbereiteten amtlichen Geobasisdaten (ATKIS Digitales Basis-Landschaftsmodell) identifiziert werden konnen, wobei geometrische und semantischen Korrekturen vorgenommen werden, um Fehlklassifizierungen weitgehend ausschliesen zu konnen. Auf Grundlage dieses Verfahrens werden in diesem Artikel deutschlandweite Analyseergebnisse zur Flachenneuinanspruchnahme von Siedlungs- und Verkehrsflachen (SuV-Flachen), differenziert nach Bundeslandern und bestimmten Nutzungsarten, fur die Bezugsjahre 2010 und 2015 vorgestellt. In einem Fazit wird auf die Voraussetzungen fur eine geobasisdatenbasierte Erhebung der Flachenneuinanspruchnahme Bezug genommen sowie kunftig zu erbringende Erganzungen des Datenbestandes benannt, die eine Erhohung der Ergebnisvaliditat herbeifuhren konnen.

The density hypothesis states that positive informa- tion is more similar than negative information, resulting in higher density of positive information in mental representa- tions. The present research applies the density hypothesis to recognition memory to explain apparent valence asymmetries in recognition memory, namely, a recognition advantage for negative information. Previous research explained this nega- tivity advantage on the basis of valence-induced affect. We predicted that positive information's higher density impairs recognition performance. Two old-new word recognition ex- periments tested whether differential density between positive and negative stimuli creates a negativity advantage in recog- nition memory, over and above valence-induced affect. In Experiment 1, participants better discriminated negative word stimuli (i.e., less false alarms) and showed a response bias towards positive words. Regression analyses showed the asymmetry to be function of density and not of valence. Experiment 2 varied stimulus density orthogonal to valence. Again, discriminability and response bias were a function of density and not of valence. We conclude that the higher den- sity of positive information causes an apparent valence asym- metry in recognition memory.

Das Flachensparziel der Bundesregierung, bis zum Jahr 2020 die tagliche Flachenneuinanspruchnahme fur Siedlung und Verkehr auf 30 Hektar pro Tag zu senken, erfordert ein zuverlassiges Flachenmonitoring, um Entwicklungen dauerhaft und mit gleichbleibender Qualitat erfassen zu kOnnen. Wichtig fur das Monitoring ist die Verwendung von kontinuierlich aktualisierten Datenquellen, um die Flachenneuinanspruchnahme, die regional mit unterschiedlicher Dynamik erfolgt, mit geringem zeitlichen Verzug abbilden zu kOnnen. Das ATKIS-Basis-DLM der Landesvermessungsverwaltungen erfullt die erforderlichen Kriterien als Eingangsdatensatz fur zyklische Flachennutzungsanalysen. Dieser Beitrag erlautert Effekte, die sich durch die in den letzten Jahren erfolgte Migration in das AAA-Modell ergeben und welche Auswirkungen diese auf das Flachenmonitoring haben.

OBJECTIVES To study the lengths and diameters of aortic segments in healthy and diseased aortas and to assess the role of aortic elongation in Type A aortic dissection (TAD) prediction. METHODS Ectasia and aneurysm were defined by ascending aorta diameters of 45-54 mm and ≥55 mm, respectively. Computed tomography angiography studies of 256 healthy, 102 ectasia, 38 aneurysm, 17 pre-TAD and 166 TAD aortas were analysed using curved multiplanar reformats. RESULTS The study groups were structurally equal. The diameter of the ascending aorta was 35 mm in the control group and was larger (P

The conformational equilibrium of the axial/equatorial conformers of 4-methylene-cyclohexyl pivalate is studied by dynamic NMR spectroscopy in a methylene chloride/freon mixture. At 153 K, the ring interconversion gets slow on the nuclear magnetic resonance timescale, the conformational equilibrium (-ΔG°) can be examined, and the barrier to ring interconversion (ΔG

Three experimental studies demonstrate that evaluation mode influences the assessment of product bundles. Consumers' preferences for product bundles are more pronounced in a joint evaluation mode, where the bundle is directly contrasted to its single counterpart (i.e., the bundle without its add-on), than in a separate evaluation mode, where the bundle is evaluated in isolation. An attentional explanation is suggested: consumers pay more attention to the unique features of a product bundle (i.e., the add-on) and, therefore, prefer the bundle more strongly in joint rather than in separate evaluation. This account bears relevance for Weaver, Garcia, and Schwarz's presenter's paradox , according to which presenters (i.e., people deciding what to offer to others) prefer bundle options, whereas evaluators (i.e., people deciding what to get for themselves) prefer single options. In the original research, presenters and evaluators provided judgments in joint and separate evaluation, respectively. Disentangling role (presenter vs. evaluator) and evaluation mode, our results show that, independent of role, people prefer bundle over single options in joint evaluations and are largely indifferent in separate evaluations. Thus, a substantial part of the original findings is attributable to evaluation mode. The presenter's paradox is revised in light of the current account.