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RESUMO Este trabalho teve o objetivo de avaliar o efeito de dois modelos de corte (radial e tangencial), considerando toras de duas classes diamétricas nas dimensões de tábuas serradas de Eucalyptus grandis e Eucalyptus dunni. As tábuas tangenciais apresentaram larguras superiores e comprimentos mais homogêneos, com menor variação em espessura. O desdobro radial apresentou maior variação em largura, mas aumentou o número de tábuas curtas. A conclusão principal é de que o desdobro tangencial, nas condições deste experimento, resultou em peças de maior dimensão e, portanto é o mais indicado.

New Italian data on the distribution of 17 Annex I Habitats are reported in this contribution. Specifically, 11 new occurrences in Natura 2000 sites are presented and 30 new cells are added in the EEA 10 km × 10 km reference grid. The new data refer to the Italian administrative regions of Apulia, Campania, Calabria, Lazio, Sardinia, Sicily and Tuscany.

Objective To evaluate safety and mechanism of action of mezagitamab (TAK-079), an anti-CD38 monoclonal antibody, in patients with moderate to severe systemic lupus erythematosus (SLE).Methods A phase 1b double-blind, placebo-controlled, multicentre study was conducted in patients with SLE receiving standard background therapy. Eligible patients were adults who met the 2012 SLICC or ACR criteria for diagnosis, had a baseline SLE Disease Activity Index 2000 (SLEDAI-2K) score of ≥6 and were positive for anti-double-stranded DNA antibodies and/or anti-extractable nuclear antigens antibodies. Patients received 45 mg, 90 mg or 135 mg of mezagitamab or placebo every 3 weeks over 12 weeks. Primary endpoints were safety and tolerability. Secondary endpoints included pharmacokinetics and pharmacodynamics. Exploratory assessments included disease activity scales, deep immune profiling and interferon pathway analysis.Results 22 patients received at least one dose of either mezagitamab or placebo. In patients exposed to mezagitamab (n=17), drug was well tolerated. Adverse event (AEs) were balanced across treatment groups, with no treatment emergent AEs exceeding grade 2. Responder analyses for Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) and SLEDAI-2K did not reveal any observable differences across treatment groups. However, there was a trend for more profound skin responses among patients with higher CLASI scores (>10) at baseline. Pharmacodynamic analysis showed median CD38 receptor occupancy up to 88.4% on CD38+ natural killer cells with concurrent depletion of these cells up to 90% in the 135 mg group. Mean reductions in IgG and autoantibodies were less than 20% in all dose groups. Cytometry by time of flight and type 1 interferon gene analysis revealed unique fingerprints that are indicative of a broad immune landscape shift following CD38 targeting.Conclusions Mezagitamab had a favourable safety profile in patients with moderate to severe SLE and elicited a pharmacodynamic effect consistent with CD38+ cell depletion. These findings reveal novel insights into the drug’s mechanism of action and support the continued investigation of mezagitamab in autoimmune diseases.

The intersection of gender and ethnicity or race lies at the root of structural discrimination and racist practices for accessing the labor market and in the workplace. This discrimination is particularly evident for women and LGBTQIA+ individuals who either belong to ethnic minorities or are migrants. However, numerous other social drivers (e.g., age, class, origins) and external factors (e.g., prejudices, gender‐based violence) further hinder their participation in the work domain and their attainment of fair labor conditions. This article explores how gender, ethnicity, and race intersect and operate with other conditions and factors to perpetuate the precarity and exploitation of women and LGBTQIA+ individuals who find themselves at the nexus of varied intersectional axes. The discussion centers around two neoliberal substate units in the Global North (South Tyrol, in Italy, and Catalonia, Spain) that register low unemployment rates and high rates of migration and that are home to historical, linguistic, and ethnic minorities. This empirical article provides for an informed debate on the lived experience of precarity and exploitation of women and LGBTQIA+ workers, and an analysis of how neoliberal substate units’ labor and gender policies could be reformed.

Implant failure in the maxilla often determine significant bone loss. Patients that had already experienced regenerative surgeries such as sinus lift and/or the placement of zygomatic implants may want to avoid further complicate rehabilitation protocols. Pterygoid implants, when feasible, offer the unique opportunity of immediate loading bypassing the maxillary sinuses an extending the anterior-posterior spread of the future prosthesis. The present case series documented the long-term success of pterygoid implants in the rehabilitation of patients who had experienced the failure of zygomatic implants and standard implants in the posterior maxilla.

Abstract Lagoecia cuminoides L. is a very rare and threatened taxon in Italy, never studied before for its ecology and potential use for human consumption. Furthermore, few data are available on the biological activities of its metabolites. A phytosociological study was carried out in the only two Italian sites, and its state of conservation was also evaluated according to the IUCN (International Union for Conservation of Nature) protocol. The collected plant material was used to make two types of extracts: hot water infusion to evaluate the use of this plant as tea and hydroalcoholic extraction to evaluate the use of it in herbal liqueur preparation. The presence of functional compounds in the extracts were investigated by gas and liquid chromatography coupled to mass spectrometry techniques. Ten non volatiles compounds were identified in the extracts, most of which derivatives of quercetin. Thirty-five volatiles compounds were also identified in the plant aerial part and extracts belonging to the chemical class of terpenoids, and among them β-farnesene, thymol, γ-terpinene and p-cymene were the most abundant. The species is characterized by compounds known for their health effects and for its potential applications for human consumption, being this species already used as decoction in some countries of Middle East. Thanks to its characteristic behaviour to grow in limiting pedoclimatic conditions this species can be potentially used in organic farms situated in rural marginal areas.

In this contribution, new data concerning the distribution of native vascular flora in Italy are presented. It includes new records, confirmations, and exclusions to the Italian administrative regions. Nomenclatural and distribution updates, published elsewhere, and corrigenda are provided as supplementary material.

Abstract Assessing wildlife health in remote regions requires a multi-faceted approach, which commonly involves convenient samplings and the need of identifying and targeting relevant and informative indicators. We applied a novel wildlife health framework and critically assessed the value of different indicators for understanding the health status and trends of an endangered tundra caribou population. Samples and data from the Dolphin and Union caribou herd were obtained between 2015 and 2021, from community-based surveillance programs and from captured animals. We documented and categorized indicators into health determinants (infectious diseases and trace elements), processes (cortisol, pathology), and health outcomes (pregnancy and body condition). During a recent period of steep population decline, our results indicated a relatively good body condition and pregnancy rates, and decreasing levels of stress, along with a low adult cow survival. We detected multiple factors as potential contributors to the reduced survival, including Brucella suis biovar 4, Erysipelothrix rhusiopathiae and lower hair trace minerals. These results remark the need of targeted studies to improve detection and investigations on caribou mortalities. We also identified differences in health indicators between captured and hunter sampled caribou, highlighting the importance of accounting for sampling biases. This integrative approach that drew on multiple data sources has provided unprecedented knowledge on the health in this herd and highlights the value of documenting individual animal health to understand causes of wildlife declines.

The growing adoption of behind-the-meter (BTM) photovoltaic (PV) systems, electric vehicle (EV) home chargers, and heat pumps (HPs) is causing increased grid congestion issues, particularly in power distribution grids. Leveraging BTM prosumer flexibility offers a cost-effective and readily available solution to address these issues without resorting to expensive and time-consuming infrastructure upgrades. This work evaluated the effectiveness of this solution by introducing a novel modeling framework that combines a rolling horizon (RH) optimal power flow (OPF) algorithm with a customized piecewise linear cost function. This framework allows for the individual control of flexible BTM assets through various control measures, while modeling the power flow (PF) and accounting for grid constraints. We demonstrated the practical utility of the proposed framework in an exemplary residential region in Schutterwald, Germany. To this end, we constructed a PF-ready grid model for the region, geographically allocated a future BTM asset mix, and generated tailored load and generation profiles for each household. We found that BTM storage systems optimized for self-consumption can fully resolve feed-in violations at HV/MV stations but only mitigate 35% of the future load violations. Implementing additional control measures is key for addressing the remaining load violations. While curative measures, e.g., temporarily limiting EV charging or HP usage, have minimal impacts, proactive measures that control both the charging and discharging of BTM storage systems can effectively address the remaining load violations, even for grids that are already operating at or near full capacity.

The objective of this study was to evaluate microbial leakage by means of genome counts, through the implant–abutment interface in dental implants with different Morse taper abutments. Fifty-six samples were prepared and divided in four groups: CMC TB (14 Cylindrical Implants–14 TiBase Abutments), CMX TB (14 Conical Implants–14 TiBase Abutments), CMX PU (14 Conical Implants–14 Universal Abutment) and CMX U (14 Tapered Implants–14 UCLA Abutments). Assemblies had their interface submerged in saliva as the contaminant. Samples were subjected either to thermomechanical cycling (2 × 106 mechanical cycles with frequency of 5 Hz and load of 120 N simultaneously with thermal cycles of 5–55 °C) or thermal cycling (5–55 °C). After cycling, the contents from the inner parts of assemblies were collected and analyzed using the Checkerboard DNA–DNA hybridization technique. Significant differences in the total genome counts were found after both thermomechanical or thermal cycling: CMX U > CMX PU > CMX TB > CMC TB. There were also significant differences in individual bacterial counts in each of the groups (p < 0.05). Irrespective of mechanical cycling, the type of abutment seems to influence not only the total microbial leakage through the interface, but also seems to significantly reflect differences considering individual target species.

In this study, the garrigues occurring in Apulia and neighboring territories (southern Italy) were surveyed in order to clarify their syntaxonomical arrangement. Many contributions previously focused on this vegetation type, often adopting different and sometimes contrasting treatments from both the nomenclature and syntaxonomical aspects. Our investigations are supported by the multivariate analysis of a dataset containing 292 phytosociological relevés, whose resulting cluster dendrogram highlights the hierarchical relationships between the examined plant communities. Overall, twenty-one associations with several sub-associations were recognized. Some of them are already known in the literature, whereas others are described here for the first time. As concerns the syntaxonomical framework, this vegetation is attributable to the class Cisto cretici-Micromerietea julianae, which in this territory is represented by the order Cisto eriocephali-Ericetalia manipuliflorae and by two alliances: Cisto eriocephali-Ericion multiflorae, grouping the more thermophilous associations usually distributed along coastlines and at low altitudes; and Cytiso spinescentis-Saturejion montanae, including the mesophilic associations occurring in mountain and sub-mountain belts.

Unmanned aerial vehicles (UAVs), commonly known as drones, present a cost-effective solution for the swift collection of data from vast and remote areas that are otherwise difficult to access. The Mediterranean Basin, known for being a hotspot for plant biodiversity, hosts several habitats and taxa of significant naturalistic value. However, many of these areas are often inaccessible to botanists, making exploration and research challenging. The aim of this paper is to involve the utilization of drone surveys and open-source software for botanical research. Our primary goal is to show the effectiveness of these tools in the field and demonstrate their practical application in Natura 2000 sites. The protected area chosen for this research is Rocca di Novara, situated in northeastern Sicily. Thanks to our drone investigations, we were able to capture images of a mountainside that is inaccessible to humans. This allowed us to observe the habitat of some species in detail. One of the most fascinating discoveries was the reappearance of Saxifraga callosa subsp. australis, which had not been confirmed in this area for over 140 years. Using drones for botanical research can boost field research, making monitoring easier and more cost-effective over time, especially in Natura 2000 sites.