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77 results on '"Tziotzios, Christos"'

56. Tissue and Circulating MicroRNA Co-expression Analysis Shows Potential Involvement of miRNAs in the Pathobiology of Frontal Fibrosing Alopecia

Author

Tziotzios, Christos, Ainali, Chrysanthi, Holmes, Susan, Cunningham, Fiona, Lwin, Su M., Palamaras, Ioulios, Bhargava, Kapil, Rymer, Janice, Stefanato, Catherine M., Kirkpatrick, Niall, Vano-Galvan, Sergio, Petridis, Christos, Fenton, David A., Simpson, Michael A., Onoufriadis, Alexandros, and McGrath, John A.

Published
2017
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59. Safety and early efficacy outcomes for lentiviral fibroblast gene therapy in recessive dystrophic epidermolysis bullosa

Author

Lwin, Su M., primary, Syed, Farhatullah, additional, Di, Wei-Li, additional, Kadiyirire, Tendai, additional, Liu, Lu, additional, Guy, Alyson, additional, Petrova, Anastasia, additional, Abdul-Wahab, Alya, additional, Reid, Fiona, additional, Phillips, Rachel, additional, Elstad, Maria, additional, Georgiadis, Christos, additional, Aristodemou, Sophia, additional, Lovell, Patricia A., additional, McMillan, James R., additional, Mee, John, additional, Miskinyte, Snaigune, additional, Titeux, Matthias, additional, Ozoemena, Linda, additional, Pramanik, Rashida, additional, Serrano, Sonia, additional, Rowles, Racheal, additional, Maurin, Clarisse, additional, Orrin, Elizabeth, additional, Martinez-Queipo, Magdalena, additional, Rashidghamat, Ellie, additional, Tziotzios, Christos, additional, Onoufriadis, Alexandros, additional, Chen, Mei, additional, Chan, Lucas, additional, Farzaneh, Farzin, additional, Del Rio, Marcela, additional, Tolar, Jakub, additional, Bauer, Johann W., additional, Larcher, Fernando, additional, Antoniou, Michael N., additional, Hovnanian, Alain, additional, Thrasher, Adrian J., additional, Mellerio, Jemima E., additional, Qasim, Waseem, additional, and McGrath, John A., additional

Published
2019
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61. Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02

Author

Tziotzios, Christos, primary, Petridis, Christos, additional, Dand, Nick, additional, Ainali, Chrysanthi, additional, Saklatvala, Jake R., additional, Pullabhatla, Venu, additional, Onoufriadis, Alexandros, additional, Pramanik, Rashida, additional, Baudry, David, additional, Lee, Sang Hyuck, additional, Wood, Kristie, additional, Liu, Lu, additional, Seegobin, Seth, additional, Michelotti, Gregory A., additional, Lwin, Su M., additional, Christou, Evangelos A. A., additional, Curtis, Charles J., additional, de Rinaldis, Emanuele, additional, Saxena, Alka, additional, Holmes, Susan, additional, Harries, Matthew, additional, Palamaras, Ioulios, additional, Cunningham, Fiona, additional, Parkins, Gregory, additional, Kaur, Manjit, additional, Farrant, Paul, additional, McDonagh, Andrew, additional, Messenger, Andrew, additional, Jones, Jennifer, additional, Jolliffe, Victoria, additional, Ali, Iaisha, additional, Ardern-Jones, Michael, additional, Mitchell, Charles, additional, Burrows, Nigel, additional, Atkar, Ravinder, additional, Banfield, Cedric, additional, Alexandroff, Anton, additional, Champagne, Caroline, additional, Cooper, Hywel L., additional, Vañó-Galván, Sergio, additional, Molina-Ruiz, Ana Maria, additional, Perez, Nerea Ormaechea, additional, Patel, Girish K., additional, Macbeth, Abby, additional, Page, Melanie, additional, Bryden, Alyson, additional, Mowbray, Megan, additional, Wahie, Shyamal, additional, Armstrong, Keith, additional, Cooke, Nicola, additional, Goodfield, Mark, additional, Man, Irene, additional, de Berker, David, additional, Dunnill, Giles, additional, Takwale, Anita, additional, Rao, Archana, additional, Siah, Tee-Wei, additional, Sinclair, Rodney, additional, Wade, Martin S., additional, Dlova, Ncoza C., additional, Setterfield, Jane, additional, Lewis, Fiona, additional, Bhargava, Kapil, additional, Kirkpatrick, Niall, additional, Estivill, Xavier, additional, Stefanato, Catherine M., additional, Flohr, Carsten, additional, Spector, Timothy, additional, Watt, Fiona M., additional, Smith, Catherine H., additional, Barker, Jonathan N., additional, Fenton, David A., additional, Simpson, Michael A., additional, and McGrath, John A., additional

Published
2019
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62. Lichen planus and lichenoid dermatoses

Author

Tziotzios, Christos, primary, Brier, Timothy, additional, Lee, John Y.W., additional, Saito, Ryo, additional, Hsu, Chao-Kai, additional, Bhargava, Kapil, additional, Stefanato, Catherine M., additional, Fenton, David A., additional, and McGrath, John A., additional

Published
2018
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68. Unravelling the genetic basis of contact allergy.

Author

McSweeney, Sheila M., White, Ian R., McFadden, John P., Tziotzios, Christos, and McGrath, John A.

Subjects
ECZEMA, ALLERGIES, GENOME-wide association studies, GENETIC correlations
Abstract

Nevertheless, major insights into key genetic determinants of contact allergy might be gained by examining those who demonstrate increased risk of contact allergy, irrespective of allergen structure or class. Bryld et al4 also examined nickel contact allergy among 630 Danish female twin pairs, demonstrating a slightly increased odds of nickel contact allergy (adjusted odds ratio 1.28, 95% confidence interval 0.33-5.00) in monozygotic compared with dizygotic twin pairs. Contact allergy occurs due to cutaneous interaction with environmental allergens that result in T-cell-mediated inflammation.1 Exposures to allergens could, therefore, be presumed to be the sole determinant of contact allergy. [Extracted from the article]

Published
2022
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69. Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA

Author

Lindhurst, Marjorie J, primary, Parker, Victoria E R, additional, Payne, Felicity, additional, Sapp, Julie C, additional, Rudge, Simon, additional, Harris, Julie, additional, Witkowski, Alison M, additional, Zhang, Qifeng, additional, Groeneveld, Matthijs P, additional, Scott, Carol E, additional, Daly, Allan, additional, Huson, Susan M, additional, Tosi, Laura L, additional, Cunningham, Michael L, additional, Darling, Thomas N, additional, Geer, Joseph, additional, Gucev, Zoran, additional, Sutton, V Reid, additional, Tziotzios, Christos, additional, Dixon, Adrian K, additional, Helliwell, Timothy, additional, O'Rahilly, Stephen, additional, Savage, David B, additional, Wakelam, Michael J O, additional, Barroso, Inês, additional, Biesecker, Leslie G, additional, and Semple, Robert K, additional

Published
2012
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76. lesson of the month (1)

Author

Phey Ming Yeap, McMillan, Nigel, Walters, Matthew, and Tziotzios, Christos

Published
2011

77. Lifetime incidence and healthcare disparities in alopecia areata: A UK population-based cohort study.

Author

Thompson AR, Tziotzios C, Nesnas J, Randall R, Czachorowski M, and Messenger A

Abstract

Background: Alopecia areata (AA) is an immune-mediated form of hair loss that can occur at any age, often with a significant mental health burden., Objectives: We aimed to provide estimates of the lifetime incidence of AA, and the impacts on mental health, healthcare utilisation and work-related outcomes, assessing variation across major sociodemographic subgroups., Methods: AA cases were identified in primary care from the UK population-based Oxford-Royal College of General Practitioners Research and Surveillance Centre database (2009-2018). Lifetime incidence of AA was estimated at age 80 using modified time-to-event models with age as the timescale, overall and stratified by sex, ethnicity, deprivation, and geography. Mental health, healthcare utilisation and work-related outcomes were assessed in the two years after AA diagnosis compared to matched unaffected controls, and stratified by the same sociodemographic subgroups ., Results: 6,961 people developed AA during the study period. Overall lifetime incidence of AA was 2.11% (95% Confidence Interval [CI] 2.06, 2.16%). Females had a higher lifetime incidence 2.35% (95%CI 2.28, 2.43%) than males 1.88% (95%CI 1.81, 1.94%). Lifetime incidence was higher in those of Asian ethnicity 5.87% (95%CI 5.51, 6.24), other 4.47% (95%CI 3.63, 5.31), mixed 4.44% (95%CI 3.50, 5.37) and black 3.03% (95%CI 2.63, 3.42) ethnicity, compared to white ethnicity 1.74% (95%CI 1.68, 1.80). Lifetime incidence was highest in those with the greatest deprivation; most-deprived quintile 2.92% (95%CI 2.77, 3.07%) compared to least-deprived 1.68% (95%CI 1.59, 1.78%). Across sociodemographic subgroups, people with AA of black ethnicity were most likely to have anxiety (adjusted Odds Ratio versus matched controls 2.92, 95%CI 1.71, 4.91), and had the greatest risk of time off work (adjusted Hazard Ratio versus matched controls 2.54, 95%CI 1.80, 3.56)., Conclusions: AA affects around 1 in 50 people over their lifetime. Incidence and the impact of AA on mental health and work outcomes, is highest in ethnic groups other than white. Clinicians should be aware of the marked heterogeneity in the incidence and impact of AA, and support targeted healthcare to groups at the highest risk of alopecia and its consequences.The study protocol for this retrospective observational study was registered with ClinicalTrials.gov (Identifier: NCT05727306)., (© The Author(s) 2024. Published by Oxford University Press on behalf of British Association of Dermatologists.)

Published
2024
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