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51. Evaluation of Predictors of Outcome in Immune Tolerance Induction Treatment of Hemophilia Α Patients with High-Responding Inhibitors

Author

Prezotti, Alessandra N L, Ferreira, Clarissa, Oliveira, Luciana, Lorenzato, Claudia, Orletti, Maria P S V, Roberti, Maria do Rosario, Ribeiro, Rosangela, Villaca, Paula Ribeiro, Montalvão, Silmara Aparecida De Lima, Medina, Samuel S, Yamaguti Hayakawa, Gabriela G, and Ozelo, Margareth C

Abstract

Introduction:Inhibitor development remains a major complication for patients with hemophilia A. Inhibitors are alloantibodies that neutralize factor (F) VIII activity, which impairs the hemostatic effect of infused FVIII concentrate. Immune tolerance induction (ITI) consists of regular FVIII administration in an attempt to eliminate the presence of inhibitors. There are several ITI protocols with similar success rates around 70%. Still, the ideal ITI regimen and the factors that can influence its success are not well defined.

Published
2017
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