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52. Benefit of adjuvant systemic therapies in HR+ HER2- pT1ab node-negative breast carcinomas

Author

De Nonneville, A., primary, Gonçalves, A., additional, Boher, J.-M., additional, Classe, J.-M., additional, Cohen, M., additional, Colombo, P.-E., additional, Reyal, F., additional, Chauvet, M.-P., additional, Jouve, E., additional, Darai, E., additional, Blache, G., additional, Coutant, C., additional, Gimbergues, P., additional, Mazouni, C., additional, Rouzier, R., additional, Villet, R., additional, Crochet, P., additional, Azuar, A.-S., additional, Lambaudie, E., additional, and Houvenaeghel, G., additional

Published
2018
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53. Impact of hormone receptor status in HER2+ early breast cancer: A paradigm shift in the trastuzumab era

Author

De Nonneville, A., primary, Gonçalves, A., additional, Boher, J.-M., additional, Cohen, M., additional, Reyal, F., additional, Classe, J.-M., additional, Giard, S., additional, Colombo, P.-E., additional, Muracciol, X., additional, Darai, E., additional, Jouve, E., additional, Mazouni, C., additional, Gimbergues, P., additional, Azuar, A.-S., additional, Barranger, E., additional, Rouzier, R., additional, Villet, R., additional, Chopin, N., additional, Lambaudie, E., additional, and Houvenaeghel, G., additional

Published
2018
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59. Abstract P3-01-02: Overview of the pathological results and treatment characteristics in the first 1000 patients randomized in the SERC trial: Axillary dissection versus no axillary dissection in patients with involved sentinel node

Author

Houvenaeghel, G, primary, Cohen, M, additional, Raro, P, additional, De Troyer, J, additional, Tunon De Lara, C, additional, Guimbergues, P, additional, Gauthier, T, additional, Faure, C, additional, Vaini-Cowen, V, additional, Lantheaume, S, additional, Regis, C, additional, Darai, E, additional, Ceccato, V, additional, D'Halluin, G, additional, Del Piano, F, additional, Villet, R, additional, Jouve, E, additional, Beedassy, B, additional, Theret, P, additional, Gabelle, P, additional, Zinzindohoue, C, additional, Opinel, P, additional, Marsollier-Ferrer, C, additional, Dhainaut-Speyer, C, additional, Colombo, P-E, additional, Di Beo, V, additional, Lambaudie, E, additional, Tallet, A, additional, and Boher, J-M, additional

Published
2018
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89. Erratum à l’article « Étude randomisée comparant la promontofixation cœlioscopique à la chirurgie prothétique par voie vaginale pour le traitement des cystocèles : PROSPERE (PROSthetic PElvic organ prolapse REpair) » [J. Gynecol. Obstet. Biol. Reprod. 42(4) (2013) 334–341]

Author

Lucot, J.-P., primary, Fritel, X., additional, Debodinance, P., additional, Bader, G., additional, Cosson, M., additional, Giraudet, G., additional, Collinet, P., additional, Rubod, C., additional, Fernandez, H., additional, Fournet, S., additional, Lesavre, M., additional, Deffieux, X., additional, Faivre, E., additional, Trichot, C., additional, Demoulin, G., additional, Jacquetin, B., additional, Savary, D., additional, Botchorichvili, R., additional, Campagne-Loiseau, S., additional, Salet-Lizee, D., additional, Villet, R., additional, Gadonneix, P., additional, Delporte, P., additional, Ferry, P., additional, Aucouturier, J.-S., additional, Thirouard, Y., additional, de Tayrac, R., additional, Fatton, B., additional, Wagner, L., additional, Nadeau, C., additional, Wattiez, A., additional, Garbin, O., additional, Youssef Azer Akladios, C., additional, Thoma, V., additional, Baulon-Thaveau, E., additional, Saussine, C., additional, Hermieu, J.-F., additional, Delmas, V., additional, Blanc, S., additional, Tardif, D., additional, and Fauconnier, A., additional

Published
2013
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90. Étude randomisée comparant la promontofixation cœlioscopique à la chirurgie prothétique par voie vaginale pour le traitement des cystocèles : PROSPERE (PROSthetic PElvic organ prolapse REpair)

Author

Lucot, J.-P., primary, Fritel, X., additional, Debodinance, P., additional, Bader, G., additional, Cosson, M., additional, Giraudet, G., additional, Collinet, P., additional, Rubod, C., additional, Fernandez, H., additional, Fournet, S., additional, Lesavre, M., additional, Deffieux, X., additional, Faivre, E., additional, Trichot, C., additional, Demoulin, G., additional, Jacquetin, B., additional, Savary, D., additional, Botchorichvili, R., additional, Campagne Loiseau, S., additional, Salet-Lizee, D., additional, Villet, R., additional, Gadonneix, P., additional, Delporte, P., additional, Ferry, P., additional, Aucouturier, J.S., additional, Thirouard, Y., additional, de Tayrac, R., additional, Fatton, B., additional, Wagner, L., additional, Nadeau, C., additional, Wattiez, A., additional, Garbin, O., additional, Youssef Azer Akladios, C., additional, Thoma, V., additional, Baulon Thaveau, E., additional, Saussine, C., additional, Hermieu, J.F., additional, Delmas, V., additional, Blanc, S., additional, Tardif, D., additional, and Fauconnier, A., additional

Published
2013
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94. Impact des curages rétropéritonéaux sur la survie des patientes atteintes d’un cancer de l’ovaire à un stade avancé : le protocole CARACO

Author

Classe, J.-M., primary, Cerato, E., additional, Boursier, C., additional, Dauplat, J., additional, Pomel, C., additional, Villet, R., additional, Cuisenier, J., additional, Lorimier, G., additional, Rodier, J.-F., additional, Mathevet, P., additional, Houvenaeghel, G., additional, Leveque, J., additional, and Lécuru, F., additional

Published
2011
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95. Classical and nerve-sparing radical hysterectomy: An evaluation of the risk of injury to the autonomous pelvic nerves

Author

Ercoli, Alfredo, Delmas, V., Gadonneix, P., Fanfani, Francesco, Villet, R., Paparella, Pierluigi, Mancuso, Salvatore, Scambia, Giovanni, Ercoli A., Fanfani F. (ORCID:0000-0003-1991-7284), Paparella P., Mancuso S., Scambia G. (ORCID:0000-0003-2758-1063), Ercoli, Alfredo, Delmas, V., Gadonneix, P., Fanfani, Francesco, Villet, R., Paparella, Pierluigi, Mancuso, Salvatore, Scambia, Giovanni, Ercoli A., Fanfani F. (ORCID:0000-0003-1991-7284), Paparella P., Mancuso S., and Scambia G. (ORCID:0000-0003-2758-1063)

Abstract

Radical hysterectomy represents the treatment of choice for FIGO stage IA2-IIA cervical cancer. It is associated with several serious complications such as urinary and anorectal dysfunction due to surgical trauma to the autonomous nervous system. In order to determine those surgical steps involving the risk of nerve injury during both classical and nerve-sparing radical hysterectomy, we investigated the relationships between pelvic fascial, vascular and nervous structures in a large series of embalmed and fresh female cadavers. We showed that the extent of potential denervation after classical radical hysterectomy is directly correlated with the radicality of the operation. The surgical steps that carry a high risk of nerve injury are the resection of the uterosacral and vesicouterine ligaments and of the paracervix. A nerve-sparing approach to radical hysterectomy for cervical cancer is feasible if specific resection limits, such as the deep uterine vein, are carefully identified and respected. However, a nerve-sparing surgical effort should be balanced with the oncological priorities of removal of disease and all its potential routes of local spread.

Published
2003

97. Skin-window-induced inflammation in breast cancer patients: a study of macrophage migration

Author

Henocq E, Bernard Bizzini, and Villet R

Subjects
Antifungal Agents, medicine.medical_treatment, Inflammation, Breast Neoplasms, Dermatitis, Interferon alpha-2, Macrophage chemotaxis, Skin Window Technique, Breast cancer, Antigen, Adjuvants, Immunologic, Medicine, Macrophage, Humans, Pharmacology, business.industry, Macrophages, Cancer, Interferon-alpha, General Medicine, Immunotherapy, medicine.disease, Recombinant Proteins, Anti-Bacterial Agents, N-Formylmethionine Leucyl-Phenylalanine, Cytokine, Immunology, Cell Migration Inhibition, Female, Macrolides, medicine.symptom, business
Abstract

A decreased number of macrophages has previously been demonstrated by means of skin-window assays in operable breast cancer patients. However, in this type of cellular inflammatory response, a varying intensity of cellular activation, cellular recruitment and macrophage chemotaxis exists. In this study, we performed skin windows after stimulation by a chemo-attractant (FMLP) and a recall antigen (Candidin-latex). Cellular responses were classified in 19 breast cancer patients according to the presence (A+) or absence (A0) of macrophage activation by comparison to healthy controls. In 13 A0 patients, the admixture of a cytokine (IFN alpha) and an immunodulator (P40) to one agent or the other or both resulted in the restoration of macrophage functions. Our study shows that uniform cellular responses to chemo-attractants and antigens are observed in healthy and not immunocompromised individuals as assessed by skin-window tests. However, the cellular response recorded in immunodeficient cancer patients is altered. It also shows that the admixture to chemoattractants and antigens of particular cytokines or better still of an immunomodulator displaying a wide spectrum of activity offers a way of restoring macrophage functions. Individual responses to immunotherapy in clinical oncology may be related to such results.

Published
1993

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