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A number of Garciniaspecies accumulate benzophenone derivatives that may be useful for the treatment of breast cancer. The dereplication of new benzophenone derivatives from Garciniaspecies is challenging due to the occurrence of multiple isomers and the known compounds found in their extracts. In the current study, a strategy is described using the UPLC-QTOFMSEtechnique to identify tentatively the known and uncharacterized benzophenones of interest based upon the characteristic fragmentation ions. Several UPLC-QTOFMS peaks (a–ee) appeared to contain benzophenone derivatives, and 12 of these peaks contained compounds with MS ionization profiles not consistent with previously identified compounds from the seeds of Garcinia paucinervis, an endangered Chinese species. The targeted isolation of unidentified compounds of interest afforded five new benzophenones, paucinones E–I (1–5), which were determined by MS and NMR analysis and ECD spectroscopy. These compounds were evaluated for cytotoxicity against three breast cancer cell lines inclusive of MDA-MB-231, SKBR3, and MCF-7. These results indicate that the UPLC-QTOFMSE-guided isolation procedure is an efficient strategy for isolating new benzophenones from Garciniaspecies.

Eggplant and related Solanumspecies contain abundant caffeoylquinic acid (CQA) derivatives. Fruit of the invasive species Solanum viarumDunal contain numerous complex CQA derivatives, but only a few have been identified. The structures of two new compounds isolated from methanolic extracts of S. viarumfruit by C18-HPLC-DAD were determined using 2D NMR and MS data. Both include two 5-CQA molecules joined by glucose via ester and glycosidic linkages. The structures of compounds 1and 2(viarumacids A and B) are, respectively, 5-caffeoyl- and 3-malonyl-5-caffeoyl-[4-(1β-[6-(5-caffeoyl)quinate]glucopyranosyl)]quinic acid. The antioxidant activities determined by ABTS•+and DPPH•assays were in the order 1> 2> 5-CQA.

YVO4 nanoparticles with various morphologies were tuned directly by hydrothermal treatment in different solutions, including pure water, potassium hydroxide solution, hydrazine hydrate, ethanolamine, triethylamine, and pyridine. X-ray diffraction (XRD), Raman, and transmission electron microscopy (TEM) were utilized to characterize the structure, morphology, and size of the products, which indicated that tetragonal phase YVO4 crystallites displaying rod-like, square, and olivary shapes were obtained. It was found that the selected solvents play an important role in modulating the morphology and confining the size of the obtained products.

Ten new triterpenoids, named meliasenins I−R (1−10), one new steroid (11), and 11 related known compounds (12−22) were isolated from fruits of Melia toosendan. The structures of the new compounds were established on the basis of spectroscopic methods, including 2D NMR techniques and mass spectrometry. The relative configuration of 1, (20R*,23E)-25-hydroperoxyeupha-7,23-diene-3β,16β-diol (meliasenin I), was confirmed by single-crystal X-ray diffraction analysis. All isolated triterpenoids (1−10, 12−15) and two steroids (11, 20) were tested for their cytotoxicity against U20S human osteosarcoma and MCF-7 human breast cancer cells using the MTT assay, and some of them were significantly cytotoxic (IC50<10 μg/mL). The insecticidal properties of compounds 1−15and 20were also briefly evaluated.