Search

Your search keyword '"Wallace, W. Hamish B."' showing total 291 results
Start Over Author "Wallace, W. Hamish B."
291 results on '"Wallace, W. Hamish B."'

79. Infantile choriocarcinoma treated with chemotherapy alone

Author

Johnson, Emma J., primary, Crofton, Patricia M., additional, O'Neill, John M.D., additional, Wilkinson, A. Graham, additional, Mckenzie, Kathryn J., additional, Munro, Fraser D., additional, Myles, Lynn, additional, Seckl, Michael J., additional, and Wallace, W. Hamish B., additional

Published
2003
Full Text
View/download PDF

80. Long-term Effects of Childhood Cancer Therapy on Growth and Fertility.

Author

Carachi, Robert, Grosfeld, Jay L., Azmy, Amir F., Reece-Mills, Michelle, Bath, Louise E., Kelnar, Christopher J., and Wallace, W. Hamish B.

Abstract

Survival rates for most childhood malignancies have improved remarkably over the past decade with an overall survival rate for England and Wales for children less than 15 years of age quoted as 75% (1993 and 1997) [1]. This improvement has been attributed to advances in treatment, better supportive care, and centralizing treatment in specialized centers with entry of patients into clinical trials [2, 3]. Approximately 1 in every 640 individuals in the US between the ages of 20 and 39 years is a survivor of childhood cancer [4]. Long-term survival rates vary with cancer type, demographic characteristics such as age, gender and race, tumor characteristics such as location and extent of disease, morphology, and genetic alterations. [ABSTRACT FROM AUTHOR]

Published
2008
Full Text
View/download PDF

91. A Validated Model of Serum Anti-Mü llerian Hormone from Conception to Menopause.

Author

Kelsey, Thomas W., Wright, Phoebe, Nelson, Scott M., Anderson, Richard A., and Wallace, W. Hamish B.

Subjects
SERUM, HORMONES in the blood, OVARIAN follicle, REPRODUCTIVE health, MENOPAUSE, ADULTS, SEX (Biology)
Abstract

Background: Anti-Mü llerian hormone (AMH) is a product of growing ovarian follicles. The concentration of AMH in blood may also reflect the non-growing follicle (NGF) population, i.e. the ovarian reserve, and be of value in predicting reproductive lifespan. A full description of AMH production up to the menopause has not been previously reported. Methodology/Principal Findings: By searching the published literature for AMH concentrations in healthy pre-menopausal females, and using our own data (combined n=3,260) we have generated and robustly validated the first model of AMH concentration from conception to menopause. This model shows that 34% of the variation in AMH is due to age alone. We have shown that AMH peaks at age 24.5 years, followed by a decline to the menopause. We have also shown that there is a neonatal peak and a potential pre-pubertal peak. Our model allows us to generate normative data at all ages. Conclusions/Significance: These data highlight key inflection points in ovarian follicle dynamics. This first validated model of circulating AMH in healthy females describes a transition period in early adulthood, after which AMH reflects the progressive loss of the NGF pool. The existence of a neonatal increase in gonadal activity is confirmed for females. An improved understanding of the relationship between circulating AMH and age will lead to more accurate assessment of ovarian reserve for the individual woman. [ABSTRACT FROM AUTHOR]

Published
2011
Full Text
View/download PDF

92. Proliferating cell nuclear antigen (PCNA) allows the automatic identification of follicles in microscopic images of human ovarian tissue.

Author

Kelsey, Thomas W., Caserta, Benedicta, Castillo, Luis, Wallace, W. Hamish B., and Gonzálvez, Francisco Cóppola

Abstract

Background: Human ovarian reserve is defined by the population of nongrowing follicles (NGFs) in the ovary. Direct estimation of ovarian reserve involves the identification of NGFs in prepared ovarian tissue. Previous studies involving human tissue have used hematoxylin and eosin (HE) stain, with NGF populations estimated by human examination either of tissue under a microscope, or of images taken of this tissue. Methods: In this study we replaced HE with proliferating cell nuclear antigen (PCNA), and automated the identification and enumeration of NGFs that appear in the resulting microscopic images. We compared the automated estimates to those obtained by human experts, with the "gold standard" taken to be the average of the conservative and liberal estimates by three human experts. Results: The automated estimates were within 10% of the "gold standard", for images at both 100× and 200× magnifications. Automated analysis took longer than human analysis for several hundred images, not allowing for breaks from analysis needed by humans. Conclusion: Our results both replicate and improve on those of previous studies involving rodent ovaries, and demonstrate the viability of large-scale studies of human ovarian reserve using a combination of immunohistochemistry and computational image analysis techniques. [ABSTRACT FROM AUTHOR]

Published
2010
Full Text
View/download PDF

93. Pregnancy Outcomes among Adult Survivors of Childhood Cancer in the British Childhood Cancer Survivor Study.

Author

Reulen, Raoul C., Zeegers, Maurice P., Wallace, W. Hamish B., Frobisher, Clare, Taylor, Aliki J., Lancashire, Emma R., Winter, Dave L., and Hawkins, Mike M.

Abstract

The article presents a study that evaluates the risk of adverse pregnancy outcomes among female and male survivors of childhood cancer in British Childhood Cancer Survivor Study. It focuses on the odd ratios (ORs) of pregnancy outcomes among female and male survivors as well as calculates the different types of childhood cancer. It reveals that pregnant female survivors, who undergone abdominal radiotherapy, are at risks of premature delivery, low birth weight, as well as fewer offspring.

Published
2009
Full Text
View/download PDF

98. Female reproductive potential post-treatment for childhood cancer

Author

Burton, Kevin A, Wallace, W Hamish B, and Critchley, Hilary OD

Abstract

Survival post-treatment for childhood malignancy is now in excess of 70%. Hence female reproductive potential following treatment must be addressed. Issues concerning subsequent uterine and ovarian function, fertility options and importantly the ethics and safety of treatment approaches are discussed herein.

Published
2002
Full Text
View/download PDF

99. The late endocrine effects of childhood cancer treatment

Author

MRCP, Mark F. H. Brougham, Kelnar, Christopher J. H., FRCP, MD, Wallace, W. Hamish B., and FRCP, MD

Abstract

Whilst many children diagnosed with cancer can now realistically hope for long term survival, the consequences of cancer treatment can be particularly devastating as they enter adolescence and adulthood. Disruption of the endocrine system can result from such treatment, including growth hormone deficiency, problems in normal pubertal progression and thyroid dysfunction. Fertility can also be affected by cancer treatment received as a child, which can have a devastating impact as the patient enters adulthood. In addition, these children may encounter disorders of growth and bone metabolism due to both their initial disease and aspects of its treatment, resulting in further morbidity in later life. The aetiology and diagnosis of these problems are discussed in this review, along with therapeutic options in order to reduce their impact. Long term follow up and clinical vigilance in this patient group is vital. We must continue to strive towards improved survival from childhood cancer, but equally we must remain aware of the adverse effects of treatment, particularly in the long term, and must aim to reduce the impact of these effects as children enter adolescence and adult life.

Published
2002
Full Text
View/download PDF

100. Subfertility following treatment for childhood cancer

Author

Waring, Angela B and Wallace, W Hamish B

Abstract

The majority of children with cancer can now expect to be cured. Recent advances in assisted reproduction have focused attention on the long-term fertility outcome for these survivors. This article summarizes the current state of our knowledge about who is at risk of subfertility after childhood cancer and discusses possibilities of fertility preservation that are currently being researched.

Published
2000
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results