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62. Age‐Related Changes in the Spatial Variation of Magnetic Susceptibility of Human Articular Cartilage.

Author

Zhang, Ming, Liu, Chenglei, Lin, Huimin, Wang, Hanqi, Qin, Le, Zhang, Zhiyong, Liu, Chunlei, Lu, Yong, Yan, Fuhua, Zhang, Yuyao, and Wei, Hongjiang

Subjects
ARTICULAR cartilage, MAGNETIC declination, MAGNETIC susceptibility, SPATIAL variation, PEARSON correlation (Statistics)
Abstract

Background: Quantitative susceptibility mapping (QSM) has shown great potential for revealing the layer structure of articular cartilage based on the laminar susceptibility difference at different depths. However, more information is needed on the effects of age on the spatial distribution of magnetic susceptibility in human cartilage. Purpose: To assess the ability of QSM to quantify the age‐related differences in depth‐wise cartilage susceptibility values in healthy populations. Study Type: Prospective. Population: A total of 94 healthy asymptomatic subjects in three age cohorts: 19–30 (n = 36, 20 males), 31–50 (n = 45, 27 males), and 51–66 years (n = 13, 7 males). Field Strength/Sequence: 3D gradient echo sequences at 3.0 T. Assessment: Four cartilage compartments were analyzed, including the central lateral/medial femur (cLF/cMF) and the lateral/medial tibia (LT/MT). The spatial susceptibility profile and the corresponding 95% confidence interval (CI) of each age cohort were obtained as functions of the normalized distance from the bone–cartilage interface to the cartilage surface (cartilage depth from 0.0 to 1.0). Statistical Tests: The relationship between age and cartilage thickness of each cartilage subregion was tested by Pearson correlation with P < 0.05 considered significant. Cartilage depths with separations of 95% CIs were considered to have significant susceptibility differences between two age cohorts with a Bonferroni‐corrected P < 0.05. Results: The cartilage thickness did not change significantly with age (P value range: 0.06–0.85). Susceptibilities were significantly higher in the 51–66‐year‐olds compared with the 31–50‐year‐olds in the deep layer of cMF (cartilage depth: 0.0–0.22) and LT (0.05–0.28). Susceptibilities were significantly higher in the 51–66‐year‐olds compared with the 19–30‐year‐olds near the cartilage–bone interface of cMF (0.0–0.34), cLF (0.0–0.28), and LT (0.0–0.58). There were also significantly higher susceptibilities in the 31–50‐year‐olds compared with the 19–30‐year‐olds in the deeper regions of cMF (0.26–0.57), cLF (0.0–0.40), and LT (0.07–0.80). Data Conclusion: Age‐related susceptibility changes in the deeper regions of knee cartilage were observed using QSM. Evidence Level: 2 Technical Efficacy: Stage 2 [ABSTRACT FROM AUTHOR]

Published
2023
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63. Joint Design of a Simultaneous Reflection and Transmission RIS in Mode-Switching Mode to Assist NOMA Systems.

Author

Zhou, Xiaoping, Wang, Hanqi, and Chen, Jiajia

Subjects
*BEAMFORMING, *SIGNALS & signaling, *ARTIFICIAL joints
Abstract

Simultaneous transmitting and reflecting reconfigurable intelligent surfaces (STAR-RISs) can reflect signals and transmissive signals simultaneously and can extend the coverage of signals. A conventional RIS mainly focuses on the case where the signal source and the target are on the same side. In this paper, a STAR-RIS-assisted non-orthogonal multiple access (NOMA) downlink communication system is considered to maximize the achievable rate for users by jointly optimizing the power-allocation coefficients, active beamforming, and STAR-RIS beamforming under the mode-switching (MS) protocol. The critical information of the channel is first extracted using the Uniform Manifold Approximation and Projection (UMAP) method. Based on the key extracted channel features, STAR-RIS elements and users are clustered individually using the fuzzy C-mean clustering (FCM) method. The alternating optimization method decomposes the original optimization problem into three sub-optimization problems. Finally, the sub-problems are converted to unconstrained optimization methods using penalty functions for the solution. Simulation results show that when the number of elements of RIS is 60, the achievable rate of the STAR-RIS–NOMA system is about 18% higher than that of the RIS–NOMA system. [ABSTRACT FROM AUTHOR]

Published
2023
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65. Using QCT to evaluate bone mineral and abdominal adipose changes in patients with primary hyperparathyroidism and comparing it to DXA for bone status assessment: a retrospective case-control study

Author

Chen, Liuping, primary, Pan, Yaling, additional, Zhong, Fangyuan, additional, Yuan, Tian-Jiao, additional, Wang, Hanqi, additional, Chen, Tongtong, additional, Lv, Haiying, additional, Cheng, Xiaoguang, additional, Liu, Jian-Min, additional, and Lu, Yong, additional

Published
2022
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73. Additional file 1 of A novel nanobody-heavy chain antibody against Angiopoietin-like protein 3 reduces plasma lipids and relieves nonalcoholic fatty liver disease

Author

Hu, Xiaozhi, Fan, Jiajun, Ma, Qianqian, Han, Lei, Cao, Zhonglian, Xu, Caili, Luan, Jingyun, Jing, Guangjun, Nan, Yanyang, Wu, Tao, Zhang, Yuting, Wang, Hanqi, Zhang, Yuanzhen, and Ju, Dianwen

Abstract

Additional file 1: Figure S1. ELISA assay of plasmatic antibody titer from pre-immune and immunized alpaca (n = 3). The value ratio of post/pre-immune plasmatic ELISA ≥ 2.1 is recorded as positive (*). Figure S2. Evaluation the insertion rate of correct VHH clones in library. The PCR products of positive clones inserted VHH genes were about 700 bp. Figure S3. The weight (A) and TG content (B) of white adipose tissue (epiWAT) and hearts (n = 5). All tissue were acquired at the end of multiple lipids-lowering treatments. Figure S4. Insulin tolerance test (ITT, A) and glucose tolerance test (GTT, B) were performed at the 6th week of multiple lipids-lowering treatments (n = 5). Figure S5. Long-term C44-Fc injection did not manifest systemic toxicity in mice. H&E staining of major organs (heart, spleen, lung, kidney and brain) after 4-week treatment were presented.

Published
2022
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74. Additional file 1 of The involvement of extracellular ATP in regulating the stunted growth of Arabidopsis plants by repeated wounding

Author

Shi, Zhenzhen, Wang, Hanqi, Zhang, Yuejing, Jia, Lingyun, Pang, Hailong, Feng, Hanqing, and Wang, Xin

Abstract

Additional file 1: Table S1. Effect of the repeated wounding on the leaf exATP level of the WT and p2k1-3 mutant seedlings. The values represent means ± SD from twenty independent seedlings. The values in the control (21 days) were set to 1.000 to facilitate the comparison among the different treatments. The means denoted by the same letter did not significantly differ at P < 0.05 among the different treatment.

Published
2022
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77. The application value of computed tomography and magnetic resonance imaging sinography/fistulography in evaluating chronic wounds: a prospective study

Author

Wang, Hanqi, primary, Yakupu, Aobuliaximu, additional, Ma, Xian, additional, Tao, Guilu, additional, Zhang, Di, additional, Li, Zhihui, additional, Pan, Yalin, additional, Chen, Tongtong, additional, Chen, Liuping, additional, Lv, Haiying, additional, Yan, Fuhua, additional, Lu, Shuliang, additional, and Lu, Yong, additional

Published
2021
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80. Editorial for "Characterization of Age‐Related and Sex‐Related Differences of Relaxation Parameters in the Intervertebral Disc Using MR‐Fingerprinting".

Author

Wang, Hanqi and Lu, Yong

Subjects
INTERVERTEBRAL disk, HUMAN fingerprints, MAGNETIC resonance imaging, NUCLEUS pulposus, HUMAN body, MUSCULOSKELETAL system
Abstract

This article discusses the use of magnetic resonance imaging (MRI) and magnetic resonance fingerprinting (MRF) to assess tissue composition and properties in the human body. MRF is a novel technique that can generate multiple quantitative property maps, such as T1, T2, and T1ρ. The article highlights the application of MRF in evaluating the intervertebral disc (IVD) and its potential for detecting IVD degeneration. It also explores the correlation between age and IVD properties, as well as the varying effects of gender on IVD. However, the study acknowledges limitations such as a small sample size and the need for further validation of MRF in evaluating the IVD. [Extracted from the article]

Published
2024
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88. P2Y12 receptor-mediated activation of spinal microglia and p38MAPK pathway contribute to cancer-induced bone pain

Author

Liu, Mingjuan, Yao, Ming, Wang, Hanqi, Xu, Longsheng, Zheng, Ying, Huang, Bing, Ni, Huadong, Xu, Shijie, Zhou, Xuyan, and Lian, Qingquan

Subjects
cancer-induced bone pain, p38MAPK pathway, P2Y12 receptor, cytokines, Original Research
Abstract

Background Cancer-induced bone pain (CIBP) is one of the most challenging clinical problems due to a lack of understanding the mechanisms. Recent evidence has demonstrated that activation of microglial G-protein-coupled P2Y12 receptor (P2Y12R) and proinflammatory cytokine production play an important role in neuropathic pain generation and maintenance. However, whether P2Y12R is involved in CIBP remains unknown. Methods The purpose of this study was to investigate the role of P2Y12R in CIBP and its molecular mechanisms. Using the bone cancer model inoculated with Walker 256 tumor cells into the left tibia of Sprague Dawley rat, we blocked spinal P2Y12R through intrathecal administration of its selective antagonist MRS2395 (400 pmol/µL, 15 µL). Results We found that not only the ionized calcium-binding adapter molecule 1 (Iba-1)-positive microglia in the ipsilateral spinal cord but also mechanical allodynia was significantly inhibited. Furthermore, it decreased the phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK) and the production of proinflammatory cytokines interleukin-1β (IL-1β) and interleukin-6 (IL-6), whereas it increased tumor necrosis factor-α (TNF-α). Conclusion Taken together, our present results suggest that microglial P2Y12R in the spinal cord may contribute to CIBP by the activation of spinal microglia and p38MAPK pathway, thus identifying a potential therapeutic target for the treatment of CIBP., Video abstract

Published
2017

96. P2Y12 receptor-mediated activation of spinal microglia and p38MAPK pathway contribute to cancer-induced bone pain

Author

Liu,Mingjuan, Yao,Ming, Wang,Hanqi, Xu,Longsheng, Zheng,Ying, Huang,Bing, Ni,Huadong, Xu,Shijie, Zhou,Xuyan, Lian,Qingquan, Liu,Mingjuan, Yao,Ming, Wang,Hanqi, Xu,Longsheng, Zheng,Ying, Huang,Bing, Ni,Huadong, Xu,Shijie, Zhou,Xuyan, and Lian,Qingquan

Abstract

Mingjuan Liu,1 Ming Yao,1,2 Hanqi Wang,1 Longsheng Xu,1 Ying Zheng,1 Bing Huang,1 Huadong Ni,1 Shijie Xu,1 Xuyan Zhou,1 Qingquan Lian2 1Department of Anesthesiology and Pain Medicine, The First Hospital of Jiaxing, The First Affiliated Hospital of Jiaxing University, Jiaxing, 2Department of Anesthesiology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China Background: Cancer-induced bone pain (CIBP) is one of the most challenging clinical problems due to a lack of understanding the mechanisms. Recent evidence has demonstrated that activation of microglial G-protein-coupled P2Y12 receptor (P2Y12R) and proinflammatory cytokine production play an important role in neuropathic pain generation and maintenance. However, whether P2Y12R is involved in CIBP remains unknown.Methods: The purpose of this study was to investigate the role of P2Y12R in CIBP and its molecular mechanisms. Using the bone cancer model inoculated with Walker 256 tumor cells into the left tibia of Sprague Dawley rat, we blocked spinal P2Y12R through intrathecal administration of its selective antagonist MRS2395 (400 pmol/µL, 15 µL).Results: We found that not only the ionized calcium-binding adapter molecule 1 (Iba-1)-positive microglia in the ipsilateral spinal cord but also mechanical allodynia was significantly inhibited. Furthermore, it decreased the phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK) and the production of proinflammatory cytokines interleukin-1β (IL-1β) and interleukin-6 (IL-6), whereas it increased tumor necrosis factor-α (TNF-α).Conclusion: Taken together, our present results suggest that microglial P2Y12R in the spinal cord may contribute to CIBP by the activation of spinal microglia and p38MAPK pathway, thus identifying a potential therapeutic target for the treatment of CIBP. Keywords: P2Y12 receptor, cancer-induced bone pain, p38MAPK pathway, cytok

Published
2017

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