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899 results on '"Wang, Ya‐Li"'

59. Identification of volatile compounds and their bioactivities from unpolar fraction of Alpinia oxyphylla Miq. and mining key genes of nootkatone biosynthesis

Author

Busayo, Fapetu Kemi, Yang, Jin-Ling, Ding, Xu-Po, Wang, Ya-Li, Gai, Cui-Juan, Wu, Fei, Dai, Hao-Fu, Mei, Wen-Li, and Chen, Hui-Qin

Abstract

In this study, analysis of the chemical constituents and bioactivities of the unpolar fractions [petroleum ether (PE) and chloroform (C)] of fruits and leaves of Alpinia oxyphylla Miq. were carried out, as well as the bioactivities of the main compounds nootkatone and valencene. From PE and C fractions of the fruits, and PE fraction of the leaves, 95.80%, 59.30%, and 82.11% of the chemical constituents respectively were identified by GC-MS. Among these identified compounds, nootkatone was the main compound in all of three fractions, while valencene was the second main compound in the PE fractions of the fruits and leaves. The bioactivities results showed that all of the fractions and the major compound nootkatone showed tyrosinase inhibitory, as well as inhibitory effect on NO production in LPS-stimulated RAW264.7 cells. While valencene only presented inhibitory activity on NO production in RAW264.7 cells. The critical genes involved in nootkatone biosynthesis in A. oxyphylla were identified from the public transcriptome datasets, and protein sequences were preliminarily analyzed. Our studies develop the usage of the unpolar fractions of A. oxyphylla, especially its leaves as the waste during its production, and meanwhile provide the gene resources for nootkatone biosynthesis.

Published
2023
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68. Intra and inter: Alterations in functional brain resting-state networks in patients with functional constipation

Author

Zhang, Dan, Zhou, Zai-Long, Xing, Ting, Zhou, Mei-Yu, Wan, Ye-Ming, Chang, Shu-Chen, Wang, Ya-Li, and Qian, Hai-Hua

Subjects
General Neuroscience
Abstract

BackgroundFunctional constipation (FCon), is a symptom-based functional gastrointestinal disorder without an organic etiology and altering brain structure and function. However, previous studies mainly focused on isolated brain regions involved in brain plasticity. Therefore, little is known about the altered large-scale interaction of brain networks in FCon.MethodsFor this study, we recruited 20 patients with FCon and 20 healthy controls. We used group independent component analysis to identify resting-state networks (RSNs) and documented intra- and inter-network alterations in the RSNs of the patients with FCon.ResultsWe found 14 independent RSNs. Differences in the intra-networks included decreased activities in the bilateral caudate of RSN 3 (strongly related to emotional and autonomic processes) and decreased activities in the left precuneus of RSN 10 (default mode network). Notably, the patients with FCon exhibited significantly decreased interactive connectivity between RSNs, mostly involving the connections to the visual perception network (RSN 7–9).ConclusionCompared with healthy controls, patients with FCon had extensive brain plastic changes within and across related RSNs. Furthermore, the macroscopic brain alterations in FCon were associated with interoceptive abilities, emotion processing, and sensorimotor control. These insights could therefore lead to the development of new treatment strategies for FCon.

Published
2022

73. Dietary zearalenone alters gill epithelial morphology and subsequent risk of infection: Insights from a freshwater grass carp (Ctenopharyngodon idella) model

Author

Zhang, Hong-Yun, primary, Wang, Ya-Li, additional, Jiang, Wei-Dan, additional, Wu, Pei, additional, Liu, Yang, additional, Zhang, Lu, additional, Mi, Hai-Feng, additional, Kuang, Sheng-Yao, additional, Tang, Ling, additional, Li, Shu-wei, additional, Zhou, Xiao-Qiu, additional, and Feng, Lin, additional

Published
2022
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80. Using New Vaginal Doses Evaluation System to Assess the Dose–Effect Relationship for Vaginal Stenosis After Definitive Radio(Chemo)Therapy for Cervical Cancer

Author

Wang, Juan, primary, Zhang, Kai-shuo, additional, Liu, Zi, additional, Wang, Tao, additional, Wang, Rui-hua, additional, Zhang, Fu-quan, additional, Yu, Lang, additional, Wang, Ya-li, additional, Wei, Li-chun, additional, Shi, Mei, additional, Li, Sha, additional, Liu, Bao-gang, additional, Shi, Fan, additional, Su, Jin, additional, Yuan, Wei, additional, Zhang, Qi ying, additional, and Zhang, Jing, additional

Published
2022
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89. Investigation on the Metabolism of Curcumin and Baicalein in Zebrafish by Liquid Chromatography-tandem Mass Spectrometry Analysis

Author

Chen Hua, Yang Feng-Qing, Wang Ya-Li, Zheng Guo-Can, Hu Guang, and Yin Shi-Jun

Subjects
Chromatography, biology, 010405 organic chemistry, 010401 analytical chemistry, Biophysics, Pharmaceutical Science, Metabolism, biology.organism_classification, 01 natural sciences, Biochemistry, 0104 chemical sciences, Baicalein, chemistry.chemical_compound, chemistry, Liquid chromatography–mass spectrometry, Curcumin, Molecular Medicine, Zebrafish
Abstract

Background: Curcumin (CUR) and baicalein (BAI) are the main active ingredients in Curcuma longa and Scutellaria baicalensis, which are used together in Jiang-Qin-Si-Wu decoction to treat gynecological diseases. On the other hand, zebrafish, as a metabolic model has become more popular, therefore, the metabolism of CUR and BAI in zebrafish is investigated in the present study. Methods: Zebrafish embryos after hatching 48 hours were divided into four experimental groups. The blank group was exposed to 1 mL of ultra-pure water. Three drug-treated groups were exposed to CUR (8 μM, 1 mL), BAI (8 μM, 1 mL), CUR and BAI (8 μM, 2 mL), respectively. After homogenization, they were analyzed by liquid chromatography-tandem mass spectrometry (LCMS/ MS). The structure of the metabolites was determined by comparing their corresponding mass spectra with those of relevant literature. According to the change of metabolite content, the metabolic effect of curcumin and baicalein was explored. Results: Five and six metabolites of CUR and BAI in zebrafish were identified by LC-MS/MS, respectively. Their metabolic pathways in zebrafish were glucuronidation and sulfation. Reduction and methylation reactions also occurred for CUR and BAI, respectively. In addition, after combined exposure of both the drugs, CUR reduced the BAI glucuronide metabolites and inhibited the metabolism of BAI in zebrafish, which is consistent with the mammalian metabolism. Conclusion: Using LC-MS/MS analysis, zebrafish is a feasible model for drug metabolism study. The results of metabolic study indicated that CUR might affect the therapeutic effect of BAI.

Published
2020

94. Zearalenone induces immuno-compromised status via TOR/NF/κB pathway and aggravates the spread of Aeromonas hydrophila to grass carp gut (Ctenopharyngodon idella)

Author

Zhang, Hong-Yun, primary, Wang, Ya-Li, additional, Zhou, Xiao-Qiu, additional, Jiang, Wei-Dan, additional, Wu, Pei, additional, Liu, Yang, additional, Zhang, Lu, additional, Mi, Hai-Feng, additional, Jiang, Jun, additional, Kuang, Sheng-Yao, additional, Tang, Ling, additional, and Feng, Lin, additional

Published
2021
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