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215 results on '"Ward, Sophia A."'

51. Kit-free automated RNA extraction for SARS-CoV-2 testing v1

Author

Greco, Maria, primary, Fidanis, Efthymios, additional, Edwards, Amelia, additional, Crawford, Margaret, additional, Cubitt, Laura, additional, Ward, Sophia, additional, Goldstone, Robert, additional, Kanu, Nnenna, additional, MacRae, James, additional, Hubank, Michael, additional, and Nicod, Jerome, additional

Published
2020
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54. Retinitis pigmentosa and progressive sensorineural hearing loss caused by a C12258A mutation in the mitochondrial MTTS2 gene

Author

Mansergh, Fiona C., Millington-Ward, Sophia, Kennan, Avril, Kiang, Anna-Sophia, Humphries, Marian, Farrar, G. Jane, Humphries, Peter, and Kenna, Paul F.

Subjects
Irish -- Health aspects, Retinitis pigmentosa -- Research, Usher's syndrome -- Research, Hearing loss -- Research, Genetic disorders -- Research, Biological sciences
Abstract

Studies have provided substantial evidence supporting the causative link between the C12258A mtDNA mutation and Usher's syndrome disorders. The disorders, characterized by hearing loss and retinitis pigmentosa-induced blindness, affect Irish kindred populations. The transversion discovered at position 12258 was heteroplasmic and found only in family members, a sequence change not observed in unaffected individuals.

Published
1999

60. Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal

Author

Turajlic, Samra, Xu, Hang, Litchfield, Kevin, Rowan, Andrew, Horswell, Stuart, Chambers, Tim, O'Brien, Tim, Lopez, Jose I, Watkins, Thomas BK, Nicol, David, Stares, Mark, Challacombe, Ben, Hazell, Steve, Chandra, Ashish, Mitchell, Thomas J, Au, Lewis, Eichler-Jonsson, Claudia, Jabbar, Faiz, Soultati, Aspasia, Chowdhury, Simon, Rudman, Sarah, Lynch, Joanna, Fernando, Archana, Stamp, Gordon, Nye, Emma, Stewart, Aengus, Xing, Wei, Smith, Jonathan C, Escudero, Mickael, Huffman, Adam, Matthews, Nik, Elgar, Greg, Phillimore, Ben, Costa, Marta, Begum, Sharmin, Ward, Sophia, Salm, Max, Boeing, Stefan, Fisher, Rosalie, Spain, Lavinia, Navas, Carolina, Grönroos, Eva, Hobor, Sebastijan, Sharma, Sarkhara, Aurangzeb, Ismaeel, Lall, Sharanpreet, Polson, Alexander, Varia, Mary, Horsfield, Catherine, Fotiadis, Nicos, Pickering, Lisa, Schwarz, Roland F, Silva, Bruno, Herrero, Javier, Luscombe, Nick M, Jamal-Hanjani, Mariam, Rosenthal, Rachel, Birkbak, Nicolai J, Wilson, Gareth A, Pipek, Orsolya, Ribli, Dezso, Krzystanek, Marcin, Csabai, Istvan, Szallasi, Zoltan, Gore, Martin, McGranahan, Nicholas, Van Loo, Peter, Campbell, Peter, Larkin, James, Swanton, Charles, TRACERx Renal Consortium, Mitchell, Thomas [0000-0003-0761-9503], and Apollo - University of Cambridge Repository

Subjects
Adult, Male, intratumor heterogeneity, branched evolution, linear evolution, renal cell cancer, Chromosomes, Clonal Evolution, Evolution, Molecular, Genetic Heterogeneity, deterministic evolution, Biomarkers, Tumor, metastasis, Humans, Longitudinal Studies, Prospective Studies, Neoplasm Metastasis, Carcinoma, Renal Cell, Alleles, Phylogeny, Aged, Aged, 80 and over, cancer evolution, Models, Statistical, tumor diversity, Genetic Variation, punctuated evolution, Sequence Analysis, DNA, Middle Aged, Prognosis, Kidney Neoplasms, Phenotype, Mutation, Disease Progression, Female, chromosome instability
Abstract

The evolutionary features of clear-cell renal cell carcinoma (ccRCC) have not been systematically studied to date. We analyzed 1,206 primary tumor regions from 101 patients recruited into the multi-center prospective study, TRACERx Renal. We observe up to 30 driver events per tumor and show that subclonal diversification is associated with known prognostic parameters. By resolving the patterns of driver event ordering, co-occurrence, and mutual exclusivity at clone level, we show the deterministic nature of clonal evolution. ccRCC can be grouped into seven evolutionary subtypes, ranging from tumors characterized by early fixation of multiple mutational and copy number drivers and rapid metastases to highly branched tumors with >10 subclonal drivers and extensive parallel evolution associated with attenuated progression. We identify genetic diversity and chromosomal complexity as determinants of patient outcome. Our insights reconcile the variable clinical behavior of ccRCC and suggest evolutionary potential as a biomarker for both intervention and surveillance.

Published
2018
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61. Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal

Author

Turajlic, Samra, Xu, Hang, Litchfield, Kevin, Rowan, Andrew, Chambers, Tim, Lopez, Jose I, Nicol, David, O'Brien, Tim, Larkin, James, Horswell, Stuart, Stares, Mark, Au, Lewis, Jamal-Hanjani, Mariam, Challacombe, Ben, Chandra, Ashish, Hazell, Steve, Eichler-Jonsson, Claudia, Soultati, Aspasia, Chowdhury, Simon, Rudman, Sarah, Lynch, Joanna, Fernando, Archana, Stamp, Gordon, Nye, Emma, Jabbar, Faiz, Spain, Lavinia, Lall, Sharanpreet, Guarch, Rosa, Falzon, Mary, Proctor, Ian, Pickering, Lisa, Gore, Martin, Watkins, Thomas BK, Ward, Sophia, Stewart, Aengus, DiNatale, Renzo, Becerra, Maria F, Reznik, Ed, Hsieh, James J, Richmond, Todd A, Mayhew, George F, Hill, Samantha M, McNally, Catherine D, Jones, Carol, Rosenbaum, Heidi, Stanislaw, Stacey, Burgess, Daniel L, Alexander, Nelson R, Swanton, Charles, PEACE, TRACERx Renal Consortium, Turajlic, Samra [0000-0001-8846-136X], Litchfield, Kevin [0000-0002-3725-0914], Lopez, Jose I [0000-0003-0842-5348], Horswell, Stuart [0000-0003-2787-1933], Spain, Lavinia [0000-0002-9356-8812], Stewart, Aengus [0000-0001-5182-653X], DiNatale, Renzo [0000-0002-7867-2881], Mayhew, George F [0000-0003-0609-6018], Swanton, Charles [0000-0002-4299-3018], and Apollo - University of Cambridge Repository

Subjects
Adult, Male, evolution of metastasis, Biopsy, renal cell cancer, loss of 9p, solitary metastasis, metastasis, Humans, Longitudinal Studies, Prospective Studies, Neoplasm Metastasis, Carcinoma, Renal Cell, Aged, Aged, 80 and over, Chromosomes, Human, Pair 14, Chromosome Mapping, Thrombosis, Middle Aged, Kidney Neoplasms, oligometastasis, Phenotype, Treatment Outcome, Mutation, Disease Progression, Female, chromosome instability, metastasectomy, Chromosomes, Human, Pair 9, Biomarkers, cytoreductive nephrectomy
Abstract

Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes that have not been systematically studied to date. Here, we analyzed 575 primary and 335 metastatic biopsies across 100 patients with metastatic ccRCC, including two cases sampledat post-mortem. Metastatic competence was afforded by chromosome complexity, and we identify 9p loss as a highly selected event driving metastasis and ccRCC-related mortality (p = 0.0014). Distinct patterns of metastatic dissemination were observed, including rapid progression to multiple tissue sites seeded by primary tumors of monoclonal structure. By contrast, we observed attenuated progression in cases characterized by high primary tumor heterogeneity, with metastatic competence acquired gradually and initial progression to solitary metastasis. Finally, we observed early divergence of primitive ancestral clones and protracted latency of up to two decades as a feature of pancreatic metastases.

Published
2018

64. Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal

Author

Especialidades médico-quirúrgicas, Medikuntza eta kirurgia espezialitateak, Turajlic, Samra, Xu, Hang, Litchfield, Kevin, Rowan, Andrew, Chambers, Tim, López Fernández de Villaverde, José Ignacio, Nicol, David, O'Brien, Tim, Larkin, James, Horswell, Stuart, Stares, Mark, Au, Lewis, Jamal-Hanjani, Mariam, Challacombe, Ben, Chandra, Ashish, Hazell, Steve, Eichler-Jonsson, Claudia, Soultati, Aspasia, Chowdhury, Simon, Rudman, Sarah, Lynch, Joanna, Archana Sinduri, Fernando, Stamp, Gordon, Nye, Emma, Jabbar, Faiz, Spain, Lavinia, Lall, Sharanpreet, Guarch, Rosa, Falzon, Mary, Proctor, Ian, Pickering, Lisa, Gore, Martin E., Watkins, Thomas B. K., Ward, Sophia, Stewart, Aengus, DiNatale, Renzo, Becerra, Maria F., Reznik, Ed, Hsieh, James J., Richmond, Todd A., Mayhew, George F., Hill, Samantha M., McNally, Catherine D., Jones, Carol, Rosenbaum, Heidi, Stanislaw, Stacey, Burgess, Daniel L., Alexander, Nelson R., Swanton, Charles, Especialidades médico-quirúrgicas, Medikuntza eta kirurgia espezialitateak, Turajlic, Samra, Xu, Hang, Litchfield, Kevin, Rowan, Andrew, Chambers, Tim, López Fernández de Villaverde, José Ignacio, Nicol, David, O'Brien, Tim, Larkin, James, Horswell, Stuart, Stares, Mark, Au, Lewis, Jamal-Hanjani, Mariam, Challacombe, Ben, Chandra, Ashish, Hazell, Steve, Eichler-Jonsson, Claudia, Soultati, Aspasia, Chowdhury, Simon, Rudman, Sarah, Lynch, Joanna, Archana Sinduri, Fernando, Stamp, Gordon, Nye, Emma, Jabbar, Faiz, Spain, Lavinia, Lall, Sharanpreet, Guarch, Rosa, Falzon, Mary, Proctor, Ian, Pickering, Lisa, Gore, Martin E., Watkins, Thomas B. K., Ward, Sophia, Stewart, Aengus, DiNatale, Renzo, Becerra, Maria F., Reznik, Ed, Hsieh, James J., Richmond, Todd A., Mayhew, George F., Hill, Samantha M., McNally, Catherine D., Jones, Carol, Rosenbaum, Heidi, Stanislaw, Stacey, Burgess, Daniel L., Alexander, Nelson R., and Swanton, Charles

Abstract

Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes that have not been systematically studied to date. Here, we analyzed 575 primary and 335 metastatic biopsies across 100 patients with metastatic ccRCC, including two cases sampledat post-mortem. Metastatic competence was afforded by chromosome complexity, and we identify 9p loss as a highly selected event driving metastasis and ccRCC-related mortality (p = 0.0014). Distinct patterns of metastatic dissemination were observed, including rapid progression to multiple tissue sites seeded by primary tumors of monoclonal structure. By contrast, we observed attenuated progression in cases characterized by high primary tumor heterogeneity, with metastatic competence acquired gradually and initial progression to solitary metastasis. Finally, we observed early divergence of primitive ancestral clones and protracted latency of up to two decades as a feature of pancreatic metastases.

Published
2018

65. Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal

Author

Especialidades médico-quirúrgicas, Medikuntza eta kirurgia espezialitateak, Turajlic, Samra, Xu, Hang, Litchfield, Kevin, Rowan, Andrew, Horswell, Stuart, Chambers, Tim, O'Brien, Tim, López Fernández de Villaverde, José Ignacio, Watkins, Thomas B. K., Nicol, David, Stares, Mark, Challacombe, Ben, Hazell, Steve, Chandra, Ashish, Mitchell, Thomas J., Au, Lewis, Eichler-Jonsson, Claudia, Jabbar, Faiz, Soultati, Aspasia, Chowdhury, Simon, Rudman, Sarah, Lynch, Joanna, Archana Sinduri, Fernando, Stamp, Gordon, Nye, Emma, Stewart, Aengus, Xing, Wei, Smith, Jonathan C., Escudero, Mickael, Huffman, Adam, Matthews, Nik, Elgar, Greg, Phillimore, Ben, Costa, Marta, Begum, Sharmin, Ward, Sophia, Salm, Max, Boeing, Stefan, Fisher, Rosalie, Spain, Lavinia, Navas, Carolina, Gronroos, Eva, Hobor, Sebastijan, Sharma, Sarkhara, Aurangzeb, Ismaeel, Lall, Sharanpreet, Polson, Alexander, Varia, Mary, Horsfield, Catherine, Fotiadis, Nicos, Pickering, Lisa, Schwarz, Roland F., Silva, Bruno, Herrero, Javier, Luscombe, Nick M., Jamal-Hanjani, Mariam, Rosenthal, Rachel, Birkbak, Nicolai J., Wilson, Gareth A., Pipek, Orsolya, Ribli, Dezso, Krzystanek, Marcin, Csabai, Istvan, Szállási, Zoltán, Gore, Martin E., McGranahan, Nicholas, Van Loo, Peter, Campbell, Peter, Larkin, James, Swanton, Charles, Especialidades médico-quirúrgicas, Medikuntza eta kirurgia espezialitateak, Turajlic, Samra, Xu, Hang, Litchfield, Kevin, Rowan, Andrew, Horswell, Stuart, Chambers, Tim, O'Brien, Tim, López Fernández de Villaverde, José Ignacio, Watkins, Thomas B. K., Nicol, David, Stares, Mark, Challacombe, Ben, Hazell, Steve, Chandra, Ashish, Mitchell, Thomas J., Au, Lewis, Eichler-Jonsson, Claudia, Jabbar, Faiz, Soultati, Aspasia, Chowdhury, Simon, Rudman, Sarah, Lynch, Joanna, Archana Sinduri, Fernando, Stamp, Gordon, Nye, Emma, Stewart, Aengus, Xing, Wei, Smith, Jonathan C., Escudero, Mickael, Huffman, Adam, Matthews, Nik, Elgar, Greg, Phillimore, Ben, Costa, Marta, Begum, Sharmin, Ward, Sophia, Salm, Max, Boeing, Stefan, Fisher, Rosalie, Spain, Lavinia, Navas, Carolina, Gronroos, Eva, Hobor, Sebastijan, Sharma, Sarkhara, Aurangzeb, Ismaeel, Lall, Sharanpreet, Polson, Alexander, Varia, Mary, Horsfield, Catherine, Fotiadis, Nicos, Pickering, Lisa, Schwarz, Roland F., Silva, Bruno, Herrero, Javier, Luscombe, Nick M., Jamal-Hanjani, Mariam, Rosenthal, Rachel, Birkbak, Nicolai J., Wilson, Gareth A., Pipek, Orsolya, Ribli, Dezso, Krzystanek, Marcin, Csabai, Istvan, Szállási, Zoltán, Gore, Martin E., McGranahan, Nicholas, Van Loo, Peter, Campbell, Peter, Larkin, James, and Swanton, Charles

Abstract

The evolutionary features of clear-cell renal cell carcinoma (ccRCC) have not been systematically studied to date. We analyzed 1,206 primary tumor regions from 101 patients recruited into the multi-center prospective study, TRACERx Renal. We observe up to 30 driver events per tumor and show that subclonal diversification is associated with known prognostic parameters. By resolving the patterns of driver event ordering, co-occurrence, and mutual exclusivity at clone level, we show the deterministic nature of clonal evolution. ccRCC can be grouped into seven evolutionary subtypes, ranging from tumors characterized by early fixation of multiple mutational and copy number drivers and rapid metastases to highly branched tumors with > 10 subclonal drivers and extensive parallel evolution associated with attenuated progression. We identify genetic diversity and chromosomal complexity as determinants of patient outcome. Our insights reconcile the variable clinical behavior of ccRCC and suggest evolutionary potential as a biomarker for both intervention and surveillance.

Published
2018

66. Fc-Optimized Anti-CD25 depletes tumor-infiltrating regulatory T Cells and synergizes with PD-1 Blockade to eradicate established tumors

Author

Arce Vargas, Frederick, Furness, Andrew J.S., Solomon, Isabelle, Joshi, Kroopa, Mekkaoui, Leila, Lesko, Marta H., Miranda Rota, Enrique, Dahan, Rony, Georgiou, Andrew, Sledzinska, Anna, Ben Aissa, Assma, Franz, Dafne, Werner Sunderland, Mariana, Wong, Yien Ning Sophia, Henry, Jake Y., O’Brien, Tim, Nicol, David, Challacombe, Ben, Beers, Stephen A., Turajlic, Samra, Gore, Martin, Larkin, James, Swanton, Charles, Chester, Kerry A., Pule, Martin, Ravetch, Jeffrey V., Marafioti, Teresa, Peggs, Karl S., Quezada, Sergio A., Spain, Lavinia, Wotherspoon, Andrew, Francis, Nicholas, Smith, Myles, Strauss, Dirk, Hayes, Andrew, Soultati, Aspasia, Stares, Mark, Lynch, Joanna, Fotiadis, Nicos, Fernando, Archana, Hazell, Steve, Chandra, Ashish, Pickering, Lisa, Rudman, Sarah, Chowdhury, Simon, Jamal-Hanjani, Mariam, Veeriah, Selvaraju, Shafi, Seema, Czyzewska-Khan, Justyna, Johnson, Diana, Laycock, Joanne, Bosshard-Carter, Leticia, Goh, Gerald, Rosenthal, Rachel, Gorman, Pat, Murugaesu, Nirupa, Hynds, Robert E., Wilson, Gareth, Birkbak, Nicolai J., Watkins, Thomas B.K., McGranahan, Nicholas, Horswell, Stuart, Mitter, Richard, Escudero, Mickael, Stewart, Aengus, Van Loo, Peter, Rowan, Andrew, Xu, Hang, Hiley, Crispin, Abbosh, Christopher, Goldman, Jacki, Stone, Richard Kevin, Denner, Tamara, Matthews, Nik, Elgar, Greg, Ward, Sophia, Biggs, Jennifer, Costa, Marta, Begum, Sharmin, Phillimore, Ben, Chambers, Tim, Nye, Emma, Graca, Sofia, Al Bakir, Maise, Hartley, John A., Lowe, Helen L., Herrero, Javier, Lawrence, David, Hayward, Martin, Panagiotopoulos, Nikolaos, Kolvekar, Shyam, Falzon, Mary, Borg, Elaine, Simeon, Celia, Hector, Gemma, Smith, Amy, Aranda, Marie, Novelli, Marco, Oukrif, Dahmane, Janes, Sam M., Thakrar, Ricky, Forster, Martin, Ahmad, Tanya, Lee, Siow Ming, Papadatos-Pastos, Dionysis, Carnell, Dawn, Mendes, Ruheena, George, Jeremy, Navani, Neal, Ahmed, Asia, Taylor, Magali, Choudhary, Junaid, Summers, Yvonne, Califano, Raffaele, Taylor, Paul, Shah, Rajesh, Krysiak, Piotr, Rammohan, Kendadai, Fontaine, Eustace, Booton, Richard, Evison, Matthew, Crosbie, Phil, Moss, Stuart, Idries, Faiza, Joseph, Leena, Bishop, Paul, Chaturved, Anshuman, Quinn, Anne Marie, Doran, Helen, Leek, Angela, Harrison, Phil, Moore, Katrina, Waddington, Rachael, Novasio, Juliette, Blackhall, Fiona, Rogan, Jane, Smith, Elaine, Dive, Caroline, Tugwood, Jonathan, Brady, Ged, Rothwell, Dominic G., Chemi, Francesca, Pierce, Jackie, Gulati, Sakshi, Naidu, Babu, Langman, Gerald, Trotter, Simon, Bellamy, Mary, Bancroft, Hollie, Kerr, Amy, Kadiri, Salma, Webb, Joanne, Middleton, Gary, Djearaman, Madava, Fennell, Dean, Shaw, Jacqui A., Le Quesne, John, Moore, David, Nakas, Apostolos, Rathinam, Sridhar, Monteiro, William, Marshall, Hilary, Nelson, Louise, Bennett, Jonathan, Riley, Joan, Primrose, Lindsay, Martinson, Luke, Anand, Girija, Khan, Sajid, Amadi, Anita, Nicolson, Marianne, Kerr, Keith, Palmer, Shirley, Remmen, Hardy, Miller, Joy, Buchan, Keith, Chetty, Mahendran, Gomersall, Lesley, Lester, Jason, Edwards, Alison, Morgan, Fiona, Adams, Haydn, Davies, Helen, Kornaszewska, Malgorzata, Attanoos, Richard, Lock, Sara, Verjee, Azmina, MacKenzie, Mairead, Wilcox, Maggie, Bell, Harriet, Iles, Natasha, Hackshaw, Allan, Ngai, Yenting, Smith, Sean, Gower, Nicole, Ottensmeier, Christian, Chee, Serena, Johnson, Benjamin, Alzetani, Aiman, Shaw, Emily, Lim, Eric, De Sousa, Paulo, Barbosa, Monica Tavares, Bowman, Alex, Jorda, Simon, Rice, Alexandra, Raubenheimer, Hilgardt, Proli, Chiara, Cufari, Maria Elena, Ronquillo, John Carlo, Kwayie, Angela, Bhayani, Harshil, Hamilton, Morag, Bakar, Yusura, Mensah, Natalie, Ambrose, Lyn, Devaraj, Anand, Buderi, Silviu, Finch, Jonathan, Azcarate, Leire, Chavan, Hema, Green, Sophie, Mashinga, Hillaria, Nicholson, Andrew G., Lau, Kelvin, Sheaff, Michael, Schmid, Peter, Conibear, John, Ezhil, Veni, Ismail, Babikir, Irvin-sellers, Melanie, Prakash, Vineet, Russell, Peter, Light, Teresa, Horey, Tracey, Danson, Sarah, Bury, Jonathan, Edwards, John, Hill, Jennifer, Matthews, Sue, Kitsanta, Yota, Suvarna, Kim, Fisher, Patricia, Keerio, Allah Dino, Shackcloth, Michael, Gosney, John, Postmus, Pieter, Feeney, Sarah, and Asante-Siaw, Julius

Subjects
hemic and immune systems, chemical and pharmacologic phenomena, R1
Abstract

Summary\ud \ud CD25 is expressed at high levels on regulatory T (Treg) cells and was initially proposed as a target for cancer immunotherapy. However, anti-CD25 antibodies have displayed limited activity against established tumors. We demonstrated that CD25 expression is largely restricted to tumor-infiltrating Treg cells in mice and humans. While existing anti-CD25 antibodies were observed to deplete Treg cells in the periphery, upregulation of the inhibitory Fc gamma receptor (FcγR) IIb at the tumor site prevented intra-tumoral Treg cell depletion, which may underlie the lack of anti-tumor activity previously observed in pre-clinical models. Use of an anti-CD25 antibody with enhanced binding to activating FcγRs led to effective depletion of tumor-infiltrating Treg cells, increased effector to Treg cell ratios, and improved control of established tumors. Combination with anti-programmed cell death protein-1 antibodies promoted complete tumor rejection, demonstrating the relevance of CD25 as a therapeutic target and promising substrate for future combination approaches in immune-oncology.

Published
2017

68. Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal

Author

Turajlic, Samra, primary, Xu, Hang, additional, Litchfield, Kevin, additional, Rowan, Andrew, additional, Chambers, Tim, additional, Lopez, Jose I., additional, Nicol, David, additional, O’Brien, Tim, additional, Larkin, James, additional, Horswell, Stuart, additional, Stares, Mark, additional, Au, Lewis, additional, Jamal-Hanjani, Mariam, additional, Challacombe, Ben, additional, Chandra, Ashish, additional, Hazell, Steve, additional, Eichler-Jonsson, Claudia, additional, Soultati, Aspasia, additional, Chowdhury, Simon, additional, Rudman, Sarah, additional, Lynch, Joanna, additional, Fernando, Archana, additional, Stamp, Gordon, additional, Nye, Emma, additional, Jabbar, Faiz, additional, Spain, Lavinia, additional, Lall, Sharanpreet, additional, Guarch, Rosa, additional, Falzon, Mary, additional, Proctor, Ian, additional, Pickering, Lisa, additional, Gore, Martin, additional, Watkins, Thomas B.K., additional, Ward, Sophia, additional, Stewart, Aengus, additional, DiNatale, Renzo, additional, Becerra, Maria F., additional, Reznik, Ed, additional, Hsieh, James J., additional, Richmond, Todd A., additional, Mayhew, George F., additional, Hill, Samantha M., additional, McNally, Catherine D., additional, Jones, Carol, additional, Rosenbaum, Heidi, additional, Stanislaw, Stacey, additional, Burgess, Daniel L., additional, Alexander, Nelson R., additional, and Swanton, Charles, additional

Published
2018
Full Text
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69. Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal

Author

Turajlic, Samra, primary, Xu, Hang, additional, Litchfield, Kevin, additional, Rowan, Andrew, additional, Horswell, Stuart, additional, Chambers, Tim, additional, O’Brien, Tim, additional, Lopez, Jose I., additional, Watkins, Thomas B.K., additional, Nicol, David, additional, Stares, Mark, additional, Challacombe, Ben, additional, Hazell, Steve, additional, Chandra, Ashish, additional, Mitchell, Thomas J., additional, Au, Lewis, additional, Eichler-Jonsson, Claudia, additional, Jabbar, Faiz, additional, Soultati, Aspasia, additional, Chowdhury, Simon, additional, Rudman, Sarah, additional, Lynch, Joanna, additional, Fernando, Archana, additional, Stamp, Gordon, additional, Nye, Emma, additional, Stewart, Aengus, additional, Xing, Wei, additional, Smith, Jonathan C., additional, Escudero, Mickael, additional, Huffman, Adam, additional, Matthews, Nik, additional, Elgar, Greg, additional, Phillimore, Ben, additional, Costa, Marta, additional, Begum, Sharmin, additional, Ward, Sophia, additional, Salm, Max, additional, Boeing, Stefan, additional, Fisher, Rosalie, additional, Spain, Lavinia, additional, Navas, Carolina, additional, Grönroos, Eva, additional, Hobor, Sebastijan, additional, Sharma, Sarkhara, additional, Aurangzeb, Ismaeel, additional, Lall, Sharanpreet, additional, Polson, Alexander, additional, Varia, Mary, additional, Horsfield, Catherine, additional, Fotiadis, Nicos, additional, Pickering, Lisa, additional, Schwarz, Roland F., additional, Silva, Bruno, additional, Herrero, Javier, additional, Luscombe, Nick M., additional, Jamal-Hanjani, Mariam, additional, Rosenthal, Rachel, additional, Birkbak, Nicolai J., additional, Wilson, Gareth A., additional, Pipek, Orsolya, additional, Ribli, Dezso, additional, Krzystanek, Marcin, additional, Csabai, Istvan, additional, Szallasi, Zoltan, additional, Gore, Martin, additional, McGranahan, Nicholas, additional, Van Loo, Peter, additional, Campbell, Peter, additional, Larkin, James, additional, and Swanton, Charles, additional

Published
2018
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70. Erratum: Corrigendum: Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

Author

Abbosh, Christopher, primary, Birkbak, Nicolai J., additional, Wilson, Gareth A., additional, Jamal-Hanjani, Mariam, additional, Constantin, Tudor, additional, Salari, Raheleh, additional, Le Quesne, John, additional, Moore, David A., additional, Veeriah, Selvaraju, additional, Rosenthal, Rachel, additional, Marafioti, Teresa, additional, Kirkizlar, Eser, additional, Watkins, Thomas B. K., additional, McGranahan, Nicholas, additional, Ward, Sophia, additional, Martinson, Luke, additional, Riley, Joan, additional, Fraioli, Francesco, additional, Al Bakir, Maise, additional, Grönroos, Eva, additional, Zambrana, Francisco, additional, Endozo, Raymondo, additional, Bi, Wenya Linda, additional, Fennessy, Fiona M., additional, Sponer, Nicole, additional, Johnson, Diana, additional, Laycock, Joanne, additional, Shafi, Seema, additional, Czyzewska-Khan, Justyna, additional, Rowan, Andrew, additional, Chambers, Tim, additional, Matthews, Nik, additional, Turajlic, Samra, additional, Hiley, Crispin, additional, Lee, Siow Ming, additional, Forster, Martin D., additional, Ahmad, Tanya, additional, Falzon, Mary, additional, Borg, Elaine, additional, Lawrence, David, additional, Hayward, Martin, additional, Kolvekar, Shyam, additional, Panagiotopoulos, Nikolaos, additional, Janes, Sam M., additional, Thakrar, Ricky, additional, Ahmed, Asia, additional, Blackhall, Fiona, additional, Summers, Yvonne, additional, Hafez, Dina, additional, Naik, Ashwini, additional, Ganguly, Apratim, additional, Kareht, Stephanie, additional, Shah, Rajesh, additional, Joseph, Leena, additional, Quinn, Anne Marie, additional, Crosbie, Phil A., additional, Naidu, Babu, additional, Middleton, Gary, additional, Langman, Gerald, additional, Trotter, Simon, additional, Nicolson, Marianne, additional, Remmen, Hardy, additional, Kerr, Keith, additional, Chetty, Mahendran, additional, Gomersall, Lesley, additional, Fennell, Dean A., additional, Nakas, Apostolos, additional, Rathinam, Sridhar, additional, Anand, Girija, additional, Khan, Sajid, additional, Russell, Peter, additional, Ezhil, Veni, additional, Ismail, Babikir, additional, Irvin-Sellers, Melanie, additional, Prakash, Vineet, additional, Lester, Jason F., additional, Kornaszewska, Malgorzata, additional, Attanoos, Richard, additional, Adams, Haydn, additional, Davies, Helen, additional, Oukrif, Dahmane, additional, Akarca, Ayse U., additional, Hartley, John A., additional, Lowe, Helen L., additional, Lock, Sara, additional, Iles, Natasha, additional, Bell, Harriet, additional, Ngai, Yenting, additional, Elgar, Greg, additional, Szallasi, Zoltan, additional, Schwarz, Roland F., additional, Herrero, Javier, additional, Stewart, Aengus, additional, Quezada, Sergio A., additional, Peggs, Karl S., additional, Van Loo, Peter, additional, Dive, Caroline, additional, Lin, C. Jimmy, additional, Rabinowitz, Matthew, additional, Aerts, Hugo J. W. L., additional, Hackshaw, Allan, additional, Shaw, Jacqui A., additional, Zimmermann, Bernhard G., additional, and Swanton, Charles, additional

Published
2017
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71. Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution

Author

McGranahan, Nicholas, primary, Rosenthal, Rachel, additional, Hiley, Crispin T., additional, Rowan, Andrew J., additional, Watkins, Thomas B.K., additional, Wilson, Gareth A., additional, Birkbak, Nicolai J., additional, Veeriah, Selvaraju, additional, Van Loo, Peter, additional, Herrero, Javier, additional, Swanton, Charles, additional, Jamal-Hanjani, Mariam, additional, Shafi, Seema, additional, Czyzewska-Khan, Justyna, additional, Johnson, Diana, additional, Laycock, Joanne, additional, Bosshard-Carter, Leticia, additional, Gorman, Pat, additional, Hynds, Robert E., additional, Wilson, Gareth, additional, McGranahan, Nicholas, additional, Horswell, Stuart, additional, Mitter, Richard, additional, Escudero, Mickael, additional, Stewart, Aengus, additional, Rowan, Andrew, additional, Xu, Hang, additional, Turajlic, Samra, additional, Hiley, Crispin, additional, Abbosh, Christopher, additional, Goldman, Jacki, additional, Stone, Richard Kevin, additional, Denner, Tamara, additional, Matthews, Nik, additional, Elgar, Greg, additional, Ward, Sophia, additional, Costa, Marta, additional, Begum, Sharmin, additional, Phillimore, Ben, additional, Chambers, Tim, additional, Nye, Emma, additional, Graca, Sofia, additional, Al Bakir, Maise, additional, Joshi, Kroopa, additional, Furness, Andrew, additional, Ben Aissa, Assma, additional, Wong, Yien Ning Sophia, additional, Georgiou, Andy, additional, Quezada, Sergio, additional, Hartley, John A., additional, Lowe, Helen L., additional, Lawrence, David, additional, Hayward, Martin, additional, Panagiotopoulos, Nikolaos, additional, Kolvekar, Shyam, additional, Falzon, Mary, additional, Borg, Elaine, additional, Marafioti, Teresa, additional, Simeon, Celia, additional, Hector, Gemma, additional, Smith, Amy, additional, Aranda, Marie, additional, Novelli, Marco, additional, Oukrif, Dahmane, additional, Janes, Sam M., additional, Thakrar, Ricky, additional, Forster, Martin, additional, Ahmad, Tanya, additional, Lee, Siow Ming, additional, Papadatos-Pastos, Dionysis, additional, Carnell, Dawn, additional, Mendes, Ruheena, additional, George, Jeremy, additional, Navani, Neal, additional, Ahmed, Asia, additional, Taylor, Magali, additional, Choudhary, Junaid, additional, Summers, Yvonne, additional, Califano, Raffaele, additional, Taylor, Paul, additional, Shah, Rajesh, additional, Krysiak, Piotr, additional, Rammohan, Kendadai, additional, Fontaine, Eustace, additional, Booton, Richard, additional, Evison, Matthew, additional, Crosbie, Phil, additional, Moss, Stuart, additional, Idries, Faiza, additional, Joseph, Leena, additional, Bishop, Paul, additional, Chaturved, Anshuman, additional, Quinn, Anne Marie, additional, Doran, Helen, additional, Leek, Angela, additional, Harrison, Phil, additional, Moore, Katrina, additional, Waddington, Rachael, additional, Novasio, Juliette, additional, Blackhall, Fiona, additional, Rogan, Jane, additional, Smith, Elaine, additional, Dive, Caroline, additional, Tugwood, Jonathan, additional, Brady, Ged, additional, Rothwell, Dominic G., additional, Chemi, Francesca, additional, Pierce, Jackie, additional, Gulati, Sakshi, additional, Naidu, Babu, additional, Langman, Gerald, additional, Trotter, Simon, additional, Bellamy, Mary, additional, Bancroft, Hollie, additional, Kerr, Amy, additional, Kadiri, Salma, additional, Webb, Joanne, additional, Middleton, Gary, additional, Djearaman, Madava, additional, Fennell, Dean, additional, Shaw, Jacqui A., additional, Le Quesne, John, additional, Moore, David, additional, Nakas, Apostolos, additional, Rathinam, Sridhar, additional, Monteiro, William, additional, Marshall, Hilary, additional, Nelson, Louise, additional, Bennett, Jonathan, additional, Riley, Joan, additional, Primrose, Lindsay, additional, Martinson, Luke, additional, Anand, Girija, additional, Khan, Sajid, additional, Amadi, Anita, additional, Nicolson, Marianne, additional, Kerr, Keith, additional, Palmer, Shirley, additional, Remmen, Hardy, additional, Miller, Joy, additional, Buchan, Keith, additional, Chetty, Mahendran, additional, Gomersall, Lesley, additional, Lester, Jason, additional, Edwards, Alison, additional, Morgan, Fiona, additional, Adams, Haydn, additional, Davies, Helen, additional, Kornaszewska, Malgorzata, additional, Attanoos, Richard, additional, Lock, Sara, additional, Verjee, Azmina, additional, MacKenzie, Mairead, additional, Wilcox, Maggie, additional, Bell, Harriet, additional, Hackshaw, Allan, additional, Ngai, Yenting, additional, Smith, Sean, additional, Gower, Nicole, additional, Ottensmeier, Christian, additional, Chee, Serena, additional, Johnson, Benjamin, additional, Alzetani, Aiman, additional, Shaw, Emily, additional, Lim, Eric, additional, De Sousa, Paulo, additional, Barbosa, Monica Tavares, additional, Bowman, Alex, additional, Jordan, Simon, additional, Rice, Alexandra, additional, Raubenheimer, Hilgardt, additional, Proli, Chiara, additional, Cufari, Maria Elena, additional, Ronquillo, John Carlo, additional, Kwayie, Angela, additional, Bhayani, Harshil, additional, Hamilton, Morag, additional, Bakar, Yusura, additional, Mensah, Natalie, additional, Ambrose, Lyn, additional, Devaraj, Anand, additional, Buderi, Silviu, additional, Finch, Jonathan, additional, Azcarate, Leire, additional, Chavan, Hema, additional, Green, Sophie, additional, Mashinga, Hillaria, additional, Nicholson, Andrew G., additional, Lau, Kelvin, additional, Sheaff, Michael, additional, Schmid, Peter, additional, Conibear, John, additional, Ezhil, Veni, additional, Ismail, Babikir, additional, Irvin-sellers, Melanie, additional, Prakash, Vineet, additional, Russell, Peter, additional, Light, Teresa, additional, Horey, Tracey, additional, Danson, Sarah, additional, Bury, Jonathan, additional, Edwards, John, additional, Hill, Jennifer, additional, Matthews, Sue, additional, Kitsanta, Yota, additional, Suvarna, Kim, additional, Fisher, Patricia, additional, Keerio, Allah Dino, additional, Shackcloth, Michael, additional, Gosney, John, additional, Postmus, Pieter, additional, Feeney, Sarah, additional, Asante-Siaw, Julius, additional, Aerts, Hugo J.W.L., additional, Dentro, Stefan, additional, and Dessimoz, Christophe, additional

Published
2017
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77. Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse

Author

Chemi, Francesca, Rothwell, Dominic G., McGranahan, Nicholas, Gulati, Sakshi, Abbosh, Chris, Pearce, Simon P., Zhou, Cong, Wilson, Gareth A., Jamal-Hanjani, Mariam, Birkbak, Nicolai, Pierce, Jackie, Kim, Chang Sik, Ferdous, Saba, Burt, Deborah J., Slane-Tan, Daniel, Gomes, Fabio, Moore, David, Shah, Rajesh, Al Bakir, Maise, Hiley, Crispin, Veeriah, Selvaraju, Summers, Yvonne, Crosbie, Philip, Ward, Sophia, Mesquita, Barbara, Dynowski, Marek, Biswas, Dhruva, Tugwood, Jonathan, Blackhall, Fiona, Miller, Crispin, Hackshaw, Allan, Brady, Ged, Swanton, Charles, and Dive, Caroline

Abstract

Approximately 50% of patients with early-stage non-small-cell lung cancer (NSCLC) who undergo surgery with curative intent will relapse within 5 years1,2. Detection of circulating tumor cells (CTCs) at the time of surgery may represent a tool to identify patients at higher risk of recurrence for whom more frequent monitoring is advised. Here we asked whether CellSearch-detected pulmonary venous CTCs (PV-CTCs) at surgical resection of early-stage NSCLC represent subclones responsible for subsequent disease relapse. PV-CTCs were detected in 48% of 100 patients enrolled into the TRACERx study3, were associated with lung-cancer-specific relapse and remained an independent predictor of relapse in multivariate analysis adjusted for tumor stage. In a case study, genomic profiling of single PV-CTCs collected at surgery revealed higher mutation overlap with metastasis detected 10 months later (91%) than with the primary tumor (79%), suggesting that early-disseminating PV-CTCs were responsible for disease relapse. Together, PV-CTC enumeration and genomic profiling highlight the potential of PV-CTCs as early predictors of NSCLC recurrence after surgery. However, the limited sensitivity of PV-CTCs in predicting relapse suggests that further studies using a larger, independent cohort are warranted to confirm and better define the potential clinical utility of PV-CTCs in early-stage NSCLC.

Published
2019
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81. Delilah.

Author

Ward, Sophia

Published
2022

82. Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy

Author

Chadderton, Naomi, primary, Palfi, Arpad, additional, Millington-Ward, Sophia, additional, Gobbo, Oliverio, additional, Overlack, Nora, additional, Carrigan, Matthew, additional, O'Reilly, Mary, additional, Campbell, Matthew, additional, Ehrhardt, Carsten, additional, Wolfrum, Uwe, additional, Humphries, Peter, additional, Kenna, Paul F, additional, and Jane Farrar, G, additional

Published
2012
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83. Erratum: A dominant mutation in RPE65 identified by whole-exome sequencing causes retinitis pigmentosa with choroidal involvement

Author

Bowne, Sara J, primary, Humphries, Marian M, additional, Sullivan, Lori S, additional, Kenna, Paul F, additional, Tam, Lawrence CS, additional, Kiang, Anna S, additional, Campbell, Matthew, additional, Weinstock, George M, additional, Koboldt, Daniel C, additional, Ding, Li, additional, Fulton, Robert S, additional, Sodergren, Erica J, additional, Allman, Denis, additional, Millington-Ward, Sophia, additional, Palfi, Arpad, additional, McKee, Alex, additional, Blanton, Susan H, additional, Slifer, Susan, additional, Konidari, Ioanna, additional, Farrar, G Jane, additional, Daiger, Stephen P, additional, and Humphries, Peter, additional

Published
2011
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84. A dominant mutation in RPE65 identified by whole-exome sequencing causes retinitis pigmentosa with choroidal involvement

Author

Bowne, Sara J, primary, Humphries, Marian M, additional, Sullivan, Lori S, additional, Kenna, Paul F, additional, Tam, Lawrence C S, additional, Kiang, Anna S, additional, Campbell, Matthew, additional, Weinstock, George M, additional, Koboldt, Daniel C, additional, Ding, Li, additional, Fulton, Robert S, additional, Sodergren, Erica J, additional, Allman, Denis, additional, Millington-Ward, Sophia, additional, Palfi, Arpad, additional, McKee, Alex, additional, Blanton, Susan H, additional, Slifer, Susan, additional, Konidari, Ioanna, additional, Farrar, G Jane, additional, Daiger, Stephen P, additional, and Humphries, Peter, additional

Published
2011
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85. Suppression and Replacement Gene Therapy for Autosomal Dominant Disease in a Murine Model of Dominant Retinitis Pigmentosa

Author

Millington-Ward, Sophia, primary, Chadderton, Naomi, additional, O'Reilly, Mary, additional, Palfi, Arpad, additional, Goldmann, Tobias, additional, Kilty, Claire, additional, Humphries, Marian, additional, Wolfrum, Uwe, additional, Bennett, Jean, additional, Humphries, Peter, additional, Kenna, Paul F, additional, and Farrar, G Jane, additional

Published
2011
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86. Adeno-Associated Virus-Mediated Rhodopsin Replacement Provides Therapeutic Benefit in Mice with a Targeted Disruption of the Rhodopsin Gene

Author

Palfi, Arpad, primary, Millington-Ward, Sophia, additional, Chadderton, Naomi, additional, O'Reilly, Mary, additional, Goldmann, Tobias, additional, Humphries, Marian M., additional, Li, Tiansen, additional, Wolfrum, Uwe, additional, Humphries, Peter, additional, Kenna, Paul F., additional, and Farrar, G. Jane, additional

Published
2010
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87. Check measurement devices

Author

Ward, Sophia

Subjects
Manufacturing industry -- Analysis, Problem solving -- Testing, Business, Engineering and manufacturing industries
Abstract

Here are manufacturing environment 'brain teasers: real-world problems that may be encountered by workers. Explanations and solutions will be in the next issue.

Published
2000

91. RNA Interference–Mediated Suppression and Replacement of Human Rhodopsin In Vivo

Author

O’Reilly, Mary, primary, Palfi, Arpad, additional, Chadderton, Naomi, additional, Millington-Ward, Sophia, additional, Ader, Marius, additional, Cronin, Thérèse, additional, Tuohy, Thérèse, additional, Auricchio, Alberto, additional, Hildinger, Markus, additional, Tivnan, Amanda, additional, McNally, Niamh, additional, Humphries, Marian M., additional, Kiang, Anna-Sophia, additional, Humphries, Pete, additional, Kenna, Paul F., additional, and Farrar, G. Jane, additional

Published
2007
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93. 1021. Suppression and Replacement Strategies for Rhodopsin-Linked Autosomal Dominant Retinitis Pigmentosa

Author

Palfi, Arpad, primary, O'Reilly, Mary, additional, Millington-Ward, Sophia, additional, Ader, Marius, additional, Chadderton, Naomi, additional, Tuohy, Gearoid, additional, Kiang, Anna-Sophia, additional, McNally, Niamh, additional, Humphries, Marian, additional, Humphries, Peter, additional, Kenna, Paul F., additional, and Farrar, G. Jane, additional

Published
2006
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95. 1020. AAV Delivery of Suppression and Replacement Constructs for Rhodopsin-Linked Autosomal Dominant Retinitis Pigmentosa

Author

Chadderton, Naomi, primary, Palfi, Arpad, additional, O'Reilly, Mary, additional, Millington-Ward, Sophia, additional, Ader, Marius, additional, Hildinger, Markus, additional, Auricchio, Alberto, additional, Tuohy, Gearoid, additional, Humphries, Peter, additional, Kenna, Paul F., additional, and Farrar, G. Jane, additional

Published
2006
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96. Toward a Gene Therapy for Dominant Disease: Validation of an RNA Interference-Based Mutation-Independent Approach

Author

Kiang, Anna-Sophia, primary, Palfi, Arpad, additional, Ader, Marius, additional, Kenna, Paul F., additional, Millington-Ward, Sophia, additional, Clark, Gerry, additional, Kennan, Avril, additional, O'Reilly, Mary, additional, Tam, Lawrence C.T., additional, Aherne, Aileen, additional, McNally, Niamh, additional, Humphries, Pete, additional, and Farrar, G. Jane, additional

Published
2005
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98. Now and Ben

Author

Ward, Sophia

Subjects
Now and Ben: The Modern Inventions of Benjamin Franklin (Book) -- Book reviews, Books -- Book reviews, Literature/writing, Publishing industry
Published
2007

99. Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy.

Author

Chadderton, Naomi, Palfi, Arpad, Millington-Ward, Sophia, Gobbo, Oliverio, Overlack, Nora, Carrigan, Matthew, O'Reilly, Mary, Campbell, Matthew, Ehrhardt, Carsten, Wolfrum, Uwe, Humphries, Peter, Kenna, Paul F, and Jane Farrar, G

Subjects
LEBER'S hereditary optic atrophy, ADENO-associated virus, GENETICS, HETEROGENEITY, RETINAL ganglion cells
Abstract

Leber hereditary optic neuropathy (LHON) is a mitochondrially inherited form of visual dysfunction caused by mutations in several genes encoding subunits of the mitochondrial respiratory NADH-ubiquinone oxidoreductase complex (complex I). Development of gene therapies for LHON has been impeded by genetic heterogeneity and the need to deliver therapies to the mitochondria of retinal ganglion cells (RGCs), the cells primarily affected in LHON. The therapy under development entails intraocular injection of a nuclear yeast gene NADH-quinone oxidoreductase (NDI1) that encodes a single subunit complex I equivalent and as such is mutation independent. NDI1 is imported into mitochondria due to an endogenous mitochondrial localisation signal. Intravitreal injection represents a clinically relevant route of delivery to RGCs not previously used for NDI1. In this study, recombinant adenoassociated virus (AAV) serotype 2 expressing NDI1 (AAV-NDI1) was shown to protect RGCs in a rotenone-induced murine model of LHON. AAV-NDI1 significantly reduced RGC death by 1.5-fold and optic nerve atrophy by 1.4-fold. This led to a significant preservation of retinal function as assessed by manganese enhanced magnetic resonance imaging and optokinetic responses. Intraocular injection of AAV-NDI1 overcomes many barriers previously associated with developing therapies for LHON and holds great therapeutic promise for a mitochondrial disorder for which there are no effective therapies. [ABSTRACT FROM AUTHOR]

Published
2013
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