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54. Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate Gene Association Resource (CARe)

Author

Wassel, Christina L., Lange, Leslie A., Keating, Brendan J., Taylor, Kira C., Johnson, Andrew D., Palmer, Cameron, Ho, Lindsey A., Smith, Nicholas L., Lange, Ethan M., Li, Yun, Yang, Qiong, Delaney, Joseph A., Tang, Weihong, Tofler, Geoffrey, Redline, Susan, Taylor, Herman A., Jr, Wilson, James G., Tracy, Russell P., Jacobs, David R., Jr, Folsom, Aaron R., Green, David, O'Donnell, Christopher J., and Reiner, Alexander P.

Published
2011
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65. Clinical Outcomes, Costs, and Healthcare Resource Utilization in Patients with Metastatic Merkel Cell Carcinoma Treated with Immune Checkpoint Inhibitors vs Chemotherapy

Author

Zheng,Ying, Yu,Ting, Mackey,Rachel H, Gayle,Julie A, Wassel,Christina L, Phatak,Hemant, Kim,Ruth, Zheng,Ying, Yu,Ting, Mackey,Rachel H, Gayle,Julie A, Wassel,Christina L, Phatak,Hemant, and Kim,Ruth

Abstract

Ying Zheng,1 Ting Yu,2 Rachel H Mackey,3,4 Julie A Gayle,3 Christina L Wassel,3 Hemant Phatak,1 Ruth Kim5 1 EMD Serono, Inc., Rockland, USA; An Affiliate of Merck KGaA, Darmstadt, Germany; 2Global Medical Affairs, EMD Serono, Inc., Rockland, MA, USA; An Affiliate of Merck KGaA, Darmstadt, Germany; 3Premier Applied Sciences, Premier, Inc, Charlotte, NC, USA; 4Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA; 5Pfizer Inc., New York, NY, USACorrespondence: Ruth KimPfizer Inc., New York, NY 10017, USATel +1 212 733-7637Email ruth.kim@pfizer.comPurpose: Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer with poor prognosis. This study compared patient characteristics, comorbidities, adverse events (AEs), treatment persistence, healthcare resource utilization (HRU) and costs in patients with metastatic MCC (mMCC) treated with immune checkpoint inhibitors (ICIs) or recommended chemotherapy per 2018 National Comprehensive Cancer Network (NCCN) Guidelines.Patients and Methods: A retrospective, observational study was conducted using data from 3/1/2015 through 12/31/2017 from the Premier Healthcare Database, a US hospital discharge database. The study included patients aged ≥ 12 years with International Classification of Diseases Codes for MCC and metastasis, categorized by their first treatment (index) during the study period (ICI or NCCN-recommended chemotherapy [chemotherapy]). Patient, hospital, and visit characteristics were assessed at the index date and Charlson Comorbidity Index (CCI) score and comorbidities during a 6-month look-back period. Clinical outcomes, including AEs and treatment persistence were assessed over 90 days and HRU and costs over 180 days post-index.Results: Of 75 patients with mMCC receiving ICIs (n=37) or chemotherapy (n=38), mean age was ≈73 years, and 21.3% had a history of immune-related (IR) conditions. Overall, ICI- and chemotherapy-treated patients were si

Published
2021

66. Abstract MP09: Untargeted 1 H Nmr Metabolomics Metabolomic Analysis Reveals Pathways Of Protection Between Mediterranean-style Diet And Incident Cardiovascular Disease In The Multi-ethnic Study Of Atherosclerosis.

Author

Wood, Alexis C, primary, Saylor, Georgina, additional, Tzoulaki, Ioanna, additional, Greenland, Philip, additional, Tracy, Russell P, additional, Post, Wendy S, additional, Lindon, John, additional, Wassel, Christina L, additional, Phan, Mimi, additional, Momin, Shabnam, additional, Ebbels, Tim, additional, Boulange, Claire, additional, Graça, Goncalo, additional, Karaman, Ibrahim, additional, Gadghil, Meghana, additional, Chekmeneva, Elena, additional, Kaluarachchi, Manuja, additional, Elliott, Paul, additional, and Herrington, David M, additional

Published
2021
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68. Fetuin-A and incident diabetes mellitus in older persons

Author

Ix, Joachim H., Wassel, Christina L., Kanaya, Alka M., Vittinghoff, Eric, Johnson, Karen C., Koster, Annemarie, Cauley, Jane A., Harris, Tamara B., Cummings, Steven R., and Shlipak, Michael G.

Subjects
Alpha fetoproteins -- Health aspects, Diabetes -- Causes of, Diabetes -- Research
Abstract

The study evaluates the association between serum fetuin-A levels and incident diabetes mellitus in older persons. Evidence suggests serum fetuin-A is associated with incident diabetes in well-functioning older persons, independent of other insulin resistance markers.

Published
2008

69. Imputation of coding variants in African Americans: better performance using data from the exome sequencing project

Author

Duan, Qing, Liu, Eric Yi, Auer, Paul L., Zhang, Guosheng, Lange, Ethan M., Jun, Goo, Bizon, Chris, Jiao, Shuo, Buyske, Steven, Franceschini, Nora, Carlson, Chris S., Hsu, Li, Reiner, Alex P., Peters, Ulrike, Haessler, Jeffrey, Curtis, Keith, Wassel, Christina L., Robinson, Jennifer G., Martin, Lisa W., Haiman, Christopher A., Le Marchand, Loic, Matise, Tara C., Hindorff, Lucia A., Crawford, Dana C., Assimes, Themistocles L., Kang, Hyun Min, Heiss, Gerardo, Jackson, Rebecca D., Kooperberg, Charles, Wilson, James G., Abecasis, Gonçalo R., North, Kari E., Nickerson, Deborah A., Lange, Leslie A., and Li, Yun

Published
2013
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75. Catechol‐O‐Methyltransferase and Cardiovascular Disease: MESA

Author

Hall, Kathryn T., primary, Battinelli, Elisabeth, additional, Chasman, Daniel I., additional, Ridker, Paul M, additional, Psaty, Bruce M., additional, Rotter, Jerome I., additional, Kaptchuk, Ted J., additional, Tracy, Russell P., additional, Wassel, Christina L., additional, and Mukamal, Kenneth J., additional

Published
2019
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80. Fetuin-A and Change in Body Composition in Older Persons

Author

Ix, Joachim H., Wassel, Christina L., Chertow, Glenn M., Koster, Annemarie, Johnson, Karen C., Tylavsky, Frances A., Cauley, Jane A., Cummings, Steven R., Harris, Tamara B., and Shlipak, Michael G.

Published
2009

81. Worldwide Frequencies of Apolipoprotein L1 Renal Risk Variants

Author

Nadkarni, Girish N, Gignoux, Christopher R, Sorokin, Elena P, Daya, Michelle, Wassel, Christina L, and Kenny, Eimear E

Subjects
Black or African American, Risk, Genotype, Genetic Variation, Humans, Genetic Predisposition to Disease, Kidney Diseases, Apolipoprotein L1, Article
Published
2018

82. Genetic analyses of diverse populations improves discovery for complex traits.

Author

Wojcik, Genevieve, Wojcik, Genevieve, Graff, Mariaelisa, Nishimura, Katherine, Tao, Ran, Haessler, Jeffrey, Gignoux, Christopher, Highland, Heather, Patel, Yesha, Sorokin, Elena, Avery, Christy, Belbin, Gillian, Bien, Stephanie, Cheng, Iona, Cullina, Sinead, Hodonsky, Chani, Hu, Yao, Huckins, Laura, Jeff, Janina, Justice, Anne, Kocarnik, Jonathan, Lim, Unhee, Lin, Bridget, Lu, Yingchang, Nelson, Sarah, Park, Sung-Shim, Poisner, Hannah, Preuss, Michael, Richard, Melissa, Schurmann, Claudia, Setiawan, Veronica, Sockell, Alexandra, Vahi, Karan, Verbanck, Marie, Vishnu, Abhishek, Walker, Ryan, Young, Kristin, Zubair, Niha, Acuña-Alonso, Victor, Ambite, Jose, Barnes, Kathleen, Boerwinkle, Eric, Bottinger, Erwin, Bustamante, Carlos, Caberto, Christian, Canizales-Quinteros, Samuel, Conomos, Matthew, Deelman, Ewa, Do, Ron, Doheny, Kimberly, Fernández-Rhodes, Lindsay, Fornage, Myriam, Hailu, Benyam, Heiss, Gerardo, Hindorff, Lucia, Jackson, Rebecca, Laurie, Cecelia, Laurie, Cathy, Li, Yuqing, Lin, Dan-Yu, Moreno-Estrada, Andres, Nadkarni, Girish, Norman, Paul, Pooler, Loreall, Reiner, Alexander, Romm, Jane, Sabatti, Chiara, Sandoval, Karla, Sheng, Xin, Stahl, Eli, Stram, Daniel, Thornton, Timothy, Wassel, Christina, Wilkens, Lynne, Winkler, Cheryl, Yoneyama, Sachi, Buyske, Steven, Haiman, Christopher, Kooperberg, Charles, Le Marchand, Loic, Loos, Ruth, Matise, Tara, North, Kari, Peters, Ulrike, Kenny, Eimear, Carlson, Christopher, Henn, Brenna, Wojcik, Genevieve, Wojcik, Genevieve, Graff, Mariaelisa, Nishimura, Katherine, Tao, Ran, Haessler, Jeffrey, Gignoux, Christopher, Highland, Heather, Patel, Yesha, Sorokin, Elena, Avery, Christy, Belbin, Gillian, Bien, Stephanie, Cheng, Iona, Cullina, Sinead, Hodonsky, Chani, Hu, Yao, Huckins, Laura, Jeff, Janina, Justice, Anne, Kocarnik, Jonathan, Lim, Unhee, Lin, Bridget, Lu, Yingchang, Nelson, Sarah, Park, Sung-Shim, Poisner, Hannah, Preuss, Michael, Richard, Melissa, Schurmann, Claudia, Setiawan, Veronica, Sockell, Alexandra, Vahi, Karan, Verbanck, Marie, Vishnu, Abhishek, Walker, Ryan, Young, Kristin, Zubair, Niha, Acuña-Alonso, Victor, Ambite, Jose, Barnes, Kathleen, Boerwinkle, Eric, Bottinger, Erwin, Bustamante, Carlos, Caberto, Christian, Canizales-Quinteros, Samuel, Conomos, Matthew, Deelman, Ewa, Do, Ron, Doheny, Kimberly, Fernández-Rhodes, Lindsay, Fornage, Myriam, Hailu, Benyam, Heiss, Gerardo, Hindorff, Lucia, Jackson, Rebecca, Laurie, Cecelia, Laurie, Cathy, Li, Yuqing, Lin, Dan-Yu, Moreno-Estrada, Andres, Nadkarni, Girish, Norman, Paul, Pooler, Loreall, Reiner, Alexander, Romm, Jane, Sabatti, Chiara, Sandoval, Karla, Sheng, Xin, Stahl, Eli, Stram, Daniel, Thornton, Timothy, Wassel, Christina, Wilkens, Lynne, Winkler, Cheryl, Yoneyama, Sachi, Buyske, Steven, Haiman, Christopher, Kooperberg, Charles, Le Marchand, Loic, Loos, Ruth, Matise, Tara, North, Kari, Peters, Ulrike, Kenny, Eimear, Carlson, Christopher, and Henn, Brenna

Abstract

Genome-wide association studies (GWAS) have laid the foundation for investigations into the biology of complex traits, drug development and clinical guidelines. However, the majority of discovery efforts are based on data from populations of European ancestry1-3. In light of the differential genetic architecture that is known to exist between populations, bias in representation can exacerbate existing disease and healthcare disparities. Critical variants may be missed if they have a low frequency or are completely absent in European populations, especially as the field shifts its attention towards rare variants, which are more likely to be population-specific4-10. Additionally, effect sizes and their derived risk prediction scores derived in one population may not accurately extrapolate to other populations11,12. Here we demonstrate the value of diverse, multi-ethnic participants in large-scale genomic studies. The Population Architecture using Genomics and Epidemiology (PAGE) study conducted a GWAS of 26 clinical and behavioural phenotypes in 49,839 non-European individuals. Using strategies tailored for analysis of multi-ethnic and admixed populations, we describe a framework for analysing diverse populations, identify 27 novel loci and 38 secondary signals at known loci, as well as replicate 1,444 GWAS catalogue associations across these traits. Our data show evidence of effect-size heterogeneity across ancestries for published GWAS associations, substantial benefits for fine-mapping using diverse cohorts and insights into clinical implications. In the United States-where minority populations have a disproportionately higher burden of chronic conditions13-the lack of representation of diverse populations in genetic research will result in inequitable access to precision medicine for those with the highest burden of disease. We strongly advocate for continued, large genome-wide efforts in diverse populations to maximize genetic discovery and reduce health dis

Published
2019

84. Erratum to “Increased hepatocyte growth factor levels over 2 years are associated with coronary heart disease: The Multi-Ethnic Study of Atherosclerosis (MESA)” [Am Heart J (2019) 30–34]

Author

Decker, Paul A., primary, Larson, Nicholas B., additional, Bell, Elizabeth J., additional, Pankow, James S., additional, Hanson, Naomi Q., additional, Wassel, Christina L., additional, Tsai, Michael Y., additional, and Bielinski, Suzette J., additional

Published
2019
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85. APOL1 Kidney Risk Variants and Cardiovascular Disease: An Individual Participant Data Meta-Analysis

Author

Grams, Morgan E., primary, Surapaneni, Aditya, additional, Ballew, Shoshana H., additional, Appel, Lawrence J., additional, Boerwinkle, Eric, additional, Boulware, L. Ebony, additional, Chen, Teresa K., additional, Coresh, Josef, additional, Cushman, Mary, additional, Divers, Jasmin, additional, Gutiérrez, Orlando M., additional, Irvin, Marguerite R., additional, Ix, Joachim H., additional, Kopp, Jeffrey B., additional, Kuller, Lewis H., additional, Langefeld, Carl D., additional, Lipkowitz, Michael S., additional, Mukamal, Kenneth J., additional, Musani, Solomon K., additional, Naik, Rakhi P., additional, Pajewski, Nicholas M., additional, Peralta, Carmen A., additional, Tin, Adrienne, additional, Wassel, Christina L., additional, Wilson, James G., additional, Winkler, Cheryl A., additional, Young, Bessie A., additional, Zakai, Neil A., additional, and Freedman, Barry I., additional

Published
2019
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87. Genetics of Chronic Kidney Disease Stages Across Ancestries: The PAGE Study

Author

Lin, Bridget M., primary, Nadkarni, Girish N., additional, Tao, Ran, additional, Graff, Mariaelisa, additional, Fornage, Myriam, additional, Buyske, Steven, additional, Matise, Tara C., additional, Highland, Heather M., additional, Wilkens, Lynne R., additional, Carlson, Christopher S., additional, Park, S. Lani, additional, Setiawan, V. Wendy, additional, Ambite, Jose Luis, additional, Heiss, Gerardo, additional, Boerwinkle, Eric, additional, Lin, Dan-Yu, additional, Morris, Andrew P., additional, Loos, Ruth J. F., additional, Kooperberg, Charles, additional, North, Kari E., additional, Wassel, Christina L., additional, and Franceschini, Nora, additional

Published
2019
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90. Kidney function and multiple hemostatic markers: cross sectional associations in the multi-ethnic study of atherosclerosis

Author

Peralta Carmen A, Palmas Walter, Fried Linda F, Folsom Aaron R, Cushman Mary, Dubin Ruth, Wassel Christina, and Shlipak Michael G

Subjects
Diseases of the genitourinary system. Urology, RC870-923
Abstract

Abstract Background Defined as estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m2, chronic kidney disease (CKD) is strongly and independently associated with cardiovascular and overall mortality. We hypothesized that reduced kidney function would be characterized by abnormalities of hemostasis. Methods We tested cross-sectional associations between (eGFR) and multiple hemostatic markers among 6751 participants representing a broad spectrum of kidney function in the Multi-Ethnic Study of Atherosclerosis (MESA). Kidney function was measured using cystatin C (eGFRcys) or creatinine, using CKD Epidemiology Collaboration (eGFRcr). Hemostatic markers included soluble thrombomodulin (sTM), soluble tissue factor (sTF), D-Dimer, von Willebrand factor (vWF), factor VIII, plasmin-antiplasmin complex (PAP), tissue factor pathway inhibitor (TFPI), plasminogen activator inhibitor-1 (PAI-1), and fibrinogen. Associations were tested using multivariable linear regression with adjustment for demographics and comorbidities. Results In comparison to persons with eGFRcys >90 ml/min/1.73 m2, subjects with eGFRcys < 60 ml/min/1.73 m2 had adjusted levels of sTM, sTF, D-Dimer, PAP, Factor VIII, TFPI, vWF and fibrinogen that were respectively 86%, 68%, 44%, 22%, 17%, 15%, 12% and 6% higher. Subjects with eGFRcys 60-90 ml/min/1.73 m2 had adjusted levels that were respectively 16%, 14%, 12%, 6%, 6%, 6%, 11% and 4% higher (p < 0.05 for all). Percent differences were not significantly different when groups were categorized by eGFRcr. Conclusions Throughout a broad spectrum of kidney function, lower eGFR was associated with higher levels of hemostatic markers. Dysregulation of hemostasis may be a mechanism by which reduced kidney function promotes higher cardiovascular risk.

Published
2011
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91. Worldwide Frequencies of APOL1 Renal Risk Variants

Author

Nadkarni, Girish N., primary, Gignoux, Christopher R., additional, Sorokin, Elena P., additional, Daya, Michelle, additional, Rahman, Rayees, additional, Barnes, Kathleen C., additional, Wassel, Christina L., additional, and Kenny, Eimear E., additional

Published
2018
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92. Novel Genetic Variants are Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SCL1A3 and EPHB2

Author

Nielson, Carrie M, Liu, Ching-Ti, Smith, Albert V, Ackert-Bicknell, Cheryl L, Reppe, Sjur, Johanna, Jakobsdottir, Wassel, Christina, Register, Thomas C, Oei, Ling, Alonso Lopez, Nerea, Oei, Edwin H, Parimi, Neeta, Samelson, Elizabeth J, Nalls, Mike A, Zmuda, Joseph, Lang, Thomas, Bouxsein, Mary, Latourelle, Jeanne, Claussnitzer, Melina, Siggeirsdottir, Kristin, Srikanth, Priya, Lorentzen, Erik, Vandenput, Liesbeth, Langefeld, Carl, Raffield, Laura, Terry, Greg, Cox, Amanda J, Allison, Matthew A, Criqui, Michael H, Bowden, Don, Ikram, M Arfan, Mellström, Dan, Karlsson, Magnus K, Carr, John, Budoff, Matthew, Phillips, Caroline, Cupples, L Adrienne, Chou, Wen-Chi, Myers, Richard H, Ralston, Stuart H, Gautvik, Kaare M, Cawthon, Peggy M, Cummings, Steven, Karasik, David, Rivadeneira, Fernando, Gudnason, Vilmundur, Orwoll, Eric S, Harris, Tamara B, Ohlsson, Claes, Kiel, Douglas P, and Hsu, Yi-Hsiang

Abstract

Genome-wide association studies (GWAS) have revealed numerous loci for areal bone mineral density (aBMD). We completed the first GWAS meta-analysis (N = 15,275) of lumbar spine volumetric BMD (vBMD) measured by quantitative computed tomography (QCT), allowing for examination of the trabecular bone compartment. SNPs that were significantly associated with vBMD were also examined in two GWAS meta-analyses to determine associations with morphometric vertebral fracture in (N = 21,701) and clinical vertebral fracture (N = 5,893). Expression QTL analyses of iliac crest biopsies were performed in 84 postmenopausal women, and murine osteoblast expression of genes implicated by eQTL or by proximity to vBMD-associated SNPs was examined. We identified significant vBMD associations with five loci, including 1p36.12, containing WNT4 and ZBTB40; 8q24, containing TNFRSF11B; and 13q14, containing AKAP11 and TNFSF11. Two loci (5p13 and 1p36.12) also contained associations with radiographic and clinical vertebral fracture, respectively. In 5p13, rs2468531 (minor allele frequency [MAF] = 3%) was associated with higher vBMD (β = 0.22, p = 1.9 × 10(-8) ) and decreased risk of radiographic vertebral fracture (OR = 0.75; false discovery rate [FDR] p = 0.01). In 1p36.12, rs12742784 (MAF = 21%) was associated with higher vBMD (β = 0.09, p = 1.2 × 10(-10) ) and decreased risk of clinical vertebral fracture (OR =0.82; FDR p = 7.4 × 10(-4) ). Both SNPs are non-coding and were associated with increased mRNA expression levels in human bone biopsies: rs2468531 with SLC1A3 (β = 0.28, FDR p = 0.01, involved in glutamate signaling and osteogenic response to mechanical loading) and rs12742784 with EPHB2 (β = 0.12, FDR p = 1.7 × 10(-3) , functions in bone-related ephrin signaling). Both genes are expressed in murine osteoblasts. This is the first study to link SLC1A3 and EPHB2 to clinically relevant vertebral osteoporosis phenotypes. These results may help elucidate vertebral bone biology and novel approaches to reducing vertebral fracture incidence. This article is protected by copyright. All rights reserved.

Published
2016

94. Generalization and fine mapping of red blood cell trait genetic associations to multi‐ethnic populations: The PAGE study

Author

Hodonsky, Chani J., primary, Schurmann, Claudia, additional, Schick, Ursula M., additional, Kocarnik, Jonathan, additional, Tao, Ran, additional, van Rooij, Frank J. A., additional, Wassel, Christina, additional, Buyske, Steve, additional, Fornage, Myriam, additional, Hindorff, Lucia A., additional, Floyd, James S., additional, Ganesh, Santhi K., additional, Lin, Dan‐Yu, additional, North, Kari E., additional, Reiner, Alex P., additional, Loos, Ruth J. F., additional, Kooperberg, Charles, additional, and Avery, Christy L., additional

Published
2018
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100. Multiethnic Exome-Wide Association Study of Subclinical AtherosclerosisCLINICAL PERSPECTIVE

Author

Boerwinkle, Eric, Vojinovic, Dina, Becker, Diane M., Van Setten, Jessica, Heckbert, Susan R., Bowden, Donald W., Oudkerk, Matthijs, Heiss, Gerardo, Yao, Jie, Deary, Ian J., Goodarzi, Mark O., Bis, Joshua C., Rotter, Jerome I., Fuster, Valentin, Išgum, Ivana, Guo, Xiuqing, Taylor, Kent D., Lyytikäinen, Leo-Pekka, Li-Gao, Ruifang, Rivadeneira, Fernando, Kavousi, Maryam, Sartori, Samantha, Dörr, Marcus, Smith, Albert V., Psaty, Bruce M., Kathiresan, Sekar, Völzke, Henry, Kral, Brian G., O'Donnell, Christopher J., Baber, Usman, Newman, Anne B., Rader, Daniel J., Peyser, Patricia A., Mehran, Roxana, Nguyen, Khanh-Dung, Tada, Hayato, Trompet, Stella, De Mutsert, Renée, Feitosa, Mary F., De Jong, Pim A., Natarajan, Pradeep, Mitchell, Braxton D., Yanek, Lisa R., Massaro, Joe, Vaidya, Dhananjay, Peloso, Gina M., Turner, Stephen T., Franco, Oscar H., Bielak, Lawrence F., Borecki, Ingrid B., Harris, Tamara B., Hoffmann, Udo, Raitakari, Olli T., Marioni, Riccardo E., Jukema, J. Wouter, Gudnason, Vilmundur, Mook-Kanamori, Dennis O., Teumer, Alexander, Cupples, L. Adrienne, Kardia, Sharon L.R., Amin, Najaf, Post, Wendy, Hwang, Shih-Jen, Chen, Yii-Der Ida, Pankow, James S., Mathias, Rasika, Rosendaal, Frits, Stitziel, Nathan O., North, Kari E., Wassel, Christina L., Wardlaw, Joanna M., Lehtimäki, Terho, Van Duijn, Cornelia M., Jhun, Min A, Yerges-Armstrong, Laura M., Isaacs, Aaron, Reilly, Dermot F., De Koning, Harry, Franceschini, Nora, Van Der Lugt, Aad, Becker, Lewis C., Felix, Stephan B., Raffield, Laura M., Dehghan, Abbas, Wojczynski, Mary K., Weiss, Stefan, Wilson, James G., Kähönen, Mika, Launer, Lenore J., Mosley, Thomas H., Demirkan, Ayse, O'Connell, Jeffrey R., De Vos, Bob D., Schminke, Ulf, Province, Michael A., Völker, Uwe, Carr, J. Jeffrey, Uitterlinden, Andre G., Cox, Amanda J., and Hofman, Albert

Subjects
cardiovascular diseases
Abstract

The burden of subclinical atherosclerosis in asymptomatic individuals is heritable and associated with elevated risk of developing clinical coronary heart disease (CHD). We sought to identify genetic variants in protein-coding regions associated with subclinical atherosclerosis and the risk of subsequent CHD.

Published
2016
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