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Human-Object Interaction (HOI), as an important problem in computer vision, requires locating the human-object pair and identifying the interactive relationships between them. The HOI instance has a greater span in spatial, scale, and task than the individual object instance, making its detection more susceptible to noisy backgrounds. To alleviate the disturbance of noisy backgrounds on HOI detection, it is necessary to consider the input image information to generate fine-grained anchors which are then leveraged to guide the detection of HOI instances. However, it is challenging for the following reasons. i) how to extract pivotal features from the images with complex background information is still an open question. ii) how to semantically align the extracted features and query embeddings is also a difficult issue. In this paper, a novel end-to-end transformer-based framework (FGAHOI) is proposed to alleviate the above problems. FGAHOI comprises three dedicated components namely, multi-scale sampling (MSS), hierarchical spatial-aware merging (HSAM) and task-aware merging mechanism (TAM). MSS extracts features of humans, objects and interaction areas from noisy backgrounds for HOI instances of various scales. HSAM and TAM semantically align and merge the extracted features and query embeddings in the hierarchical spatial and task perspectives in turn. In the meanwhile, a novel training strategy Stage-wise Training Strategy is designed to reduce the training pressure caused by overly complex tasks done by FGAHOI. In addition, we propose two ways to measure the difficulty of HOI detection and a novel dataset, i.e., HOI-SDC for the two challenges (Uneven Distributed Area in Human-Object Pairs and Long Distance Visual Modeling of Human-Object Pairs) of HOI instances detection.

Open-world object detection (OWOD), as a more general and challenging goal, requires the model trained from data on known objects to detect both known and unknown objects and incrementally learn to identify these unknown objects. The existing works which employ standard detection framework and fixed pseudo-labelling mechanism (PLM) have the following problems: (i) The inclusion of detecting unknown objects substantially reduces the model's ability to detect known ones. (ii) The PLM does not adequately utilize the priori knowledge of inputs. (iii) The fixed selection manner of PLM cannot guarantee that the model is trained in the right direction. We observe that humans subconsciously prefer to focus on all foreground objects and then identify each one in detail, rather than localize and identify a single object simultaneously, for alleviating the confusion. This motivates us to propose a novel solution called CAT: LoCalization and IdentificAtion Cascade Detection Transformer which decouples the detection process via the shared decoder in the cascade decoding way. In the meanwhile, we propose the self-adaptive pseudo-labelling mechanism which combines the model-driven with input-driven PLM and self-adaptively generates robust pseudo-labels for unknown objects, significantly improving the ability of CAT to retrieve unknown objects. Comprehensive experiments on two benchmark datasets, i.e., MS-COCO and PASCAL VOC, show that our model outperforms the state-of-the-art in terms of all metrics in the task of OWOD, incremental object detection (IOD) and open-set detection., Comment: CVPR 2023 camera-ready version

In many applications, heterogeneous treatment effects on a censored response variable are of primary interest, and it is natural to evaluate the effects at different quantiles (e.g., median). The large number of potential effect modifiers, the unknown structure of the treatment effects, and the presence of right censoring pose significant challenges. In this paper, we develop a hybrid forest approach called Hybrid Censored Quantile Regression Forest (HCQRF) to assess the heterogeneous effects varying with high-dimensional variables. The hybrid estimation approach takes advantage of the random forests and the censored quantile regression. We propose a doubly-weighted estimation procedure that consists of a redistribution-of-mass weight to handle censoring and an adaptive nearest neighbor weight derived from the forest to handle high-dimensional effect functions. We propose a variable importance decomposition to measure the impact of a variable on the treatment effect function. Extensive simulation studies demonstrate the efficacy and stability of HCQRF. The result of the simulation study also convinces us of the effectiveness of the variable importance decomposition. We apply HCQRF to a clinical trial of colorectal cancer. We achieve insightful estimations of the treatment effect and meaningful variable importance results. The result of the variable importance also confirms the necessity of the decomposition.

Few-Shot Text Classification (FSTC) imitates humans to learn a new text classifier efficiently with only few examples, by leveraging prior knowledge from historical tasks. However, most prior works assume that all the tasks are sampled from a single data source, which cannot adapt to real-world scenarios where tasks are heterogeneous and lie in different distributions. As such, existing methods may suffer from their globally knowledge-shared mechanisms to handle the task heterogeneity. On the other hand, inherent task relation are not explicitly captured, making task knowledge unorganized and hard to transfer to new tasks. Thus, we explore a new FSTC setting where tasks can come from a diverse range of data sources. To address the task heterogeneity, we propose a self-supervised hierarchical task clustering (SS-HTC) method. SS-HTC not only customizes cluster-specific knowledge by dynamically organizing heterogeneous tasks into different clusters in hierarchical levels but also disentangles underlying relations between tasks to improve the interpretability. Extensive experiments on five public FSTC benchmark datasets demonstrate the effectiveness of SS-HTC.

A biomechanical model often requires parameter estimation and selection in a known but complicated nonlinear function. Motivated by observing that data from a head-neck position tracking system, one of biomechanical models, show multiplicative time dependent errors, we develop a modified penalized weighted least squares estimator. The proposed method can be also applied to a model with non-zero mean time dependent additive errors. Asymptotic properties of the proposed estimator are investigated under mild conditions on a weight matrix and the error process. A simulation study demonstrates that the proposed estimation works well in both parameter estimation and selection with time dependent error. The analysis and comparison with an existing method for head-neck position tracking data show better performance of the proposed method in terms of the variance accounted for (VAF)., Comment: The article revised in overall

Molecular property prediction is essential for drug discovery. In recent years, deep learning methods have been introduced to this area and achieved state-of-the-art performances. However, most of existing methods ignore the intrinsic relations between molecular properties which can be utilized to improve the performances of corresponding prediction tasks. In this paper, we propose a new approach, namely Physics properties Enhanced Molecular Property prediction (PEMP), to utilize relations between molecular properties revealed by previous physics theory and physical chemistry studies. Specifically, we enhance the training of the chemical and physiological property predictors with related physics property prediction tasks. We design two different methods for PEMP, respectively based on multi-task learning and transfer learning. Both methods include a model-agnostic molecule representation module and a property prediction module. In our implementation, we adopt both the state-of-the-art molecule embedding models under the supervised learning paradigm and the pretraining paradigm as the molecule representation module of PEMP, respectively. Experimental results on public benchmark MoleculeNet show that the proposed methods have the ability to outperform corresponding state-of-the-art models., Comment: 9 pages. Published in CIKM 2022

Learning conditional densities and identifying factors that influence the entire distribution are vital tasks in data-driven applications. Conventional approaches work mostly with summary statistics, and are hence inadequate for a comprehensive investigation. Recently, there have been developments on functional regression methods to model density curves as functional outcomes. A major challenge for developing such models lies in the inherent constraint of non-negativity and unit integral for the functional space of density outcomes. To overcome this fundamental issue, we propose Wasserstein Distributional Learning (WDL), a flexible density-on-scalar regression modeling framework that starts with the Wasserstein distance $W_2$ as a proper metric for the space of density outcomes. We then introduce a heterogeneous and flexible class of Semi-parametric Conditional Gaussian Mixture Models (SCGMM) as the model class $\mathfrak{F} \otimes \mathcal{T}$. The resulting metric space $(\mathfrak{F} \otimes \mathcal{T}, W_2)$ satisfies the required constraints and offers a dense and closed functional subspace. For fitting the proposed model, we further develop an efficient algorithm based on Majorization-Minimization optimization with boosted trees. Compared with methods in the previous literature, WDL better characterizes and uncovers the nonlinear dependence of the conditional densities, and their derived summary statistics. We demonstrate the effectiveness of the WDL framework through simulations and real-world applications.

Transcriptome-wide association studies (TWAS) are powerful tools for identifying putative causal genes by integrating genome-wide association studies and gene expression data. However, most TWAS methods focus on linear associations between genes and traits, ignoring the complex nonlinear relationships that exist in biological systems. To address this limitation, we propose a novel quantile transcriptomics framework, QTWAS, that takes into account the nonlinear and heterogeneous nature of gene-trait associations. Our approach integrates a quantile-based gene expression model into the TWAS model, which allows for the discovery of nonlinear and heterogeneous gene-trait associations. By conducting comprehensive simulations and examining various psychiatric and neurodegenerative traits, we demonstrate that the proposed model outperforms traditional techniques in identifying gene-trait associations. Additionally, QTWAS can uncover important insights into nonlinear relationships between gene expression levels and phenotypes, complementing traditional TWAS approaches. We further show applications to 100 continuous traits from the UK Biobank and 10 binary traits related to brain disorders.

To mitigate the significant biases/errors in research studying the associations between PM and health, which are introduced by the coarse/inadequate assessments of PM exposure from conventional PM monitoring paradigm, a personalized monitoring system consisting of a low-cost wearable PM device is proposed. However, due to the absence of a unifying evaluation protocol for low-cost PM sensors, the evaluation results/performance specifications from existing studies/datasheets are of limited reference values when attempting to determine the best candidate for the proposed system. In this regard, the authors appeal to the research community to develop a standardized evaluation protocol for low-cost PM sensors/devices, and a unifying attempt is established in this manuscript by adopting the definitive terminology from international documents and the evaluation metrics regarded as best practices. Collocated on the rooftop of the HKUST Supersite, four empirically selected PM sensors were compared against each other and calibrated against two reference monitors. They were then evaluated against the reference following the protocol. The PlanTower PMS-A003 sensor was selected for the wearable device as it outperformed the others in terms of affordability, portability, detection capability, data quality, as well as humidity and condensation insusceptibility. An automated approach was proposed to identify and remove the condensation associated abnormal measurements. The proposed device has better affordability and portability as well as similar usability and data accessibility compared to those existing devices recognized. The first 10 devices were also evaluated and calibrated at the Supersite. Additional 120 units were manufactured and delivered to the subjects to acquire their daily PM2.5 exposures for investigating the association with subclinical atherosclerosis.

Cardiovascular diseases (CVDs) are the number one cause of death worldwide. While there is growing evidence that the atrial fibrillation (AF) has strong associations with various CVDs, this heart arrhythmia is usually diagnosed using electrocardiography (ECG) which is a risk-free, non-intrusive, and cost-efficient tool. Continuously and remotely monitoring the subjects' ECG information unlocks the potentials of prompt pre-diagnosis and timely pre-treatment of AF before the development of any life-threatening conditions/diseases. Ultimately, the CVDs associated mortality could be reduced. In this manuscript, the design and implementation of a personalized healthcare system embodying a wearable ECG device, a mobile application, and a back-end server are presented. This system continuously monitors the users' ECG information to provide personalized health warnings/feedbacks. The users are able to communicate with their paired health advisors through this system for remote diagnoses, interventions, etc. The implemented wearable ECG devices have been evaluated and showed excellent intra-consistency (CVRMS=5.5%), acceptable inter-consistency (CVRMS=12.1%), and negligible RR-interval errors (ARE<1.4%). To boost the battery life of the wearable devices, a lossy compression schema utilizing the quasi-periodic feature of ECG signals to achieve compression was proposed. Compared to the recognized schemata, it outperformed the others in terms of compression efficiency and distortion, and achieved at least 2x of CR at a certain PRD or RMSE for ECG signals from the MIT-BIH database. To enable automated AF diagnosis/screening in the proposed system, a ResNet-based AF detector was developed. For the ECG records from the 2017 PhysioNet CinC challenge, this AF detector obtained an average testing F1=85.10% and a best testing F1=87.31%, outperforming the state-of-the-art.

The success of meta-learning on existing benchmarks is predicated on the assumption that the distribution of meta-training tasks covers meta-testing tasks. Frequent violation of the assumption in applications with either insufficient tasks or a very narrow meta-training task distribution leads to memorization or learner overfitting. Recent solutions have pursued augmentation of meta-training tasks, while it is still an open question to generate both correct and sufficiently imaginary tasks. In this paper, we seek an approach that up-samples meta-training tasks from the task representation via a task up-sampling network. Besides, the resulting approach named Adversarial Task Up-sampling (ATU) suffices to generate tasks that can maximally contribute to the latest meta-learner by maximizing an adversarial loss. On few-shot sine regression and image classification datasets, we empirically validate the marked improvement of ATU over state-of-the-art task augmentation strategies in the meta-testing performance and also the quality of up-sampled tasks.

Large-photon-number quantum state is a fundamental but non-resolved request for practical quantum information applications. Here we propose an N-photon state generation scheme that is feasible and scalable, using lithium niobate on insulator circuits. Such scheme is based on the integration of a common building block called photon-number doubling unit (PDU), for deterministic single-photon parametric down-conversion and up-conversion. The PDU relies on 10^7-optical-quality-factor resonator and mW-level on-chip power, which is within the current fabrication and experiment limits. N-photon state generation schemes, with cluster and GHZ state as examples, are shown for different quantum tasks.

Vehicle re-identification (Re-ID) is urgently demanded to alleviate thepressure caused by the increasingly onerous task of urban traffic management. Multiple challenges hamper the applications of vision-based vehicle Re-ID methods: (1) The appearances of different vehicles of the same brand/model are often similar; However, (2) the appearances of the same vehicle differ significantly from different viewpoints. Previous methods mainly use manually annotated multi-attribute datasets to assist the network in getting detailed cues and in inferencing multi-view to improve the vehicle Re-ID performance. However, finely labeled vehicle datasets are usually unattainable in real application scenarios. Hence, we propose a Discriminative-Region Attention and Orthogonal-View Generation (DRA-OVG) model, which only requires identity (ID) labels to conquer the multiple challenges of vehicle Re-ID.The proposed DRA model can automatically extract the discriminative region features, which can distinguish similar vehicles. And the OVG model can generate multi-view features based on the input view features to reduce the impact of viewpoint mismatches. Finally, the distance between vehicle appearances is presented by the discriminative region features and multi-view features together. Therefore, the significance of pairwise distance measure between vehicles is enhanced in acomplete feature space. Extensive experiments substantiate the effectiveness of each proposed ingredient, and experimental results indicate that our approach achieves remarkable improvements over the state- of-the-art vehicle Re-ID methods on VehicleID and VeRi-776 datasets., Comment: 28pages,12 figures

Recent efforts on scene text erasing have shown promising results. However, existing methods require rich yet costly label annotations to obtain robust models, which limits the use for practical applications. To this end, we study an unsupervised scenario by proposing a novel Self-supervised Text Erasing (STE) framework that jointly learns to synthesize training images with erasure ground-truth and accurately erase texts in the real world. We first design a style-aware image synthesis function to generate synthetic images with diverse styled texts based on two synthetic mechanisms. To bridge the text style gap between the synthetic and real-world data, a policy network is constructed to control the synthetic mechanisms by picking style parameters with the guidance of two specifically designed rewards. The synthetic training images with erasure ground-truth are then fed to train a coarse-to-fine erasing network. To produce better erasing outputs, a triplet erasure loss is designed to enforce the refinement stage to recover background textures. Moreover, we provide a new dataset (called PosterErase), which contains 60K high-resolution posters with texts and is more challenging for the text erasing task. The proposed method has been extensively evaluated with both PosterErase and the widely-used SCUT-Enstext dataset. Notably, on PosterErase, our unsupervised method achieves 5.07 in terms of FID, with a relative performance of 20.9% over existing supervised baselines., Comment: 10 pages