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53. Fetal loss associated with excess thyroid hormone exposure

Author

Anselmo, Joao, Cao, Dingcai, Karrison, Theodore, Weiss, Roy E., and Refetoff, Samuel

Subjects
Thyroid hormones -- Influence, Fetus -- Health aspects
Abstract

The effects of thyroid hormone(TH) excess on fetuses carried by mothers with resistance to TH, who are euthyroid are studied. The result reveals that the lower birth weight and suppressed levels of TSH in unaffected infants born to affected mothers indicates that the high maternal TH levels produce fetal thyrotoxicosis.

Published
2004

58. Specificity of thyroid hormone receptor subtype and steroid receptor coactivator-1 on thyroid hormone action

Author

Sadow, Peter M., Chassande, Olivier, Gauthier, Karine, Samarut, Jacques, Xu, Jianming, O'Malley, Bert W., and Weiss, Roy E.

Subjects
Thyroid hormones -- Research, Biological sciences
Abstract

Isoforms of the thyroid hormone receptor (TR)[alpha] and TR[beta] genes mediate thyroid hormone action. How TR isoforms modulate tissue-specific thyroid hormone (TH) action remains largely unknown. The steroid receptor coactivator-1 (SRC-1) is among a group of transcriptional coactivator proteins that bind to TRs, along with other members of the nuclear receptor superfamily, and modulate the activity of genes regulated by TH. Mice deficient in SRC-1 possess decreased tissue responsiveness to TH and many steroid hormones; however, it is not known whether or not SRC-1-mediated activation of TH-regulated gene transcription in peripheral tissues, such as heart and liver, is TR isoform specific. We have generated mice deficient in TR[alpha] and SRC-1, as well as in TR[beta] and SRC-1, and investigated thyroid function tests and effects of TH deprivation and TH treatment compared with wild-type (WT) mice or those deficient in either TR or SRC-1 alone. The data show that 1) in the absence of TR[alpha] or TR[beta], SRC-1 is important for normal growth; 2) SRC-1 modulates TR[alpha] and TR[beta] effects on heart rate; 3) two new TR[beta]-dependent markers of TH action in the liver have been identified, osteopontin (upregulated) and glutathione S-transferase (downregulated); and 4) SRC-1 may mediate the hypersensitivity to TH seen in liver of TR[alpha]-deficient mice. knockout; resistance to thyroid hormone; thyrotropin

Published
2003

61. Contributors

Author

Aiello, Lloyd Paul, primary, Alexander, Erik K., additional, Allan, Carolyn A., additional, Allolio, Bruno, additional, Angelos, Peter, additional, Appu, Sree, additional, Auchus, Richard J., additional, Avruch, Joseph, additional, Axelrod, Lloyd, additional, Bahn, Rebecca S., additional, Baker, H.W.G., additional, Barnes, Randall B., additional, Bastepe, Murat, additional, Baxter, John D., additional, Beck-Peccoz, Paolo, additional, Bell, Graeme I., additional, Bilezikian, John P., additional, Bloom, Stephen R., additional, Blum, Manfred, additional, Bonnema, Steen J., additional, Botero, Diego, additional, Bouillon, Roger, additional, Boulton, Andrew J.M., additional, Braunstein, Glenn D., additional, Bringhurst, F. Richard, additional, Broekmans, Frank J., additional, Bronstein, Marcello D., additional, Brown, Edward M., additional, Bui, Chuong, additional, Burch, Col. Henry B., additional, Burger, Henry G., additional, Burney, Richard O., additional, Buse, John B., additional, Butler, Peter C., additional, Cappabianca, Paolo, additional, Caramori, Maria Luiza Avancini, additional, Carey, Robert M., additional, Carlton, Esther, additional, Carmody, David, additional, Caro, Jose F., additional, Cavagnini, Francesco, additional, Cavallerano, Jerry, additional, Cavallo, Luigi M., additional, Chan, Shu Jin, additional, Chang, R. Jeffrey, additional, Chapurlat, Roland D., additional, Chatterjee, V. Krishna, additional, Chiovato, Luca, additional, Cho, Kyung J., additional, Christophe, Daniel, additional, Chung, Teng-Teng, additional, Cidlowski, John A., additional, Clark, Adrian J.L., additional, Clark, Peter E., additional, Clemmons, David R., additional, Considine, Robert V., additional, Copinschi, Georges, additional, Copps, Kyle D., additional, Courtney, C. Hamish, additional, Cuttler, Leona, additional, Daley, Melita L., additional, Dattani, Mehul, additional, Davis, Stephen N., additional, de Divitiis, Oreste, additional, De Felice, Mario, additional, DeFronzo, Ralph A., additional, J. De Groot, Leslie, additional, de Kretser, David, additional, Delli, Ahmed J., additional, Delmas, Pierre D., additional, Demay, Marie B., additional, Devroey, Paul, additional, Di Lauro, Roberto, additional, Dinneen, Sean F., additional, Dumont, Jacques E., additional, Dungan, Kathleen M., additional, Drucker, Daniel J., additional, Econs, Michael J., additional, Ehrmann, David A., additional, Eisenhofer, Graeme, additional, Erickson, Gregory F., additional, Eriksson, Barbro, additional, Espiner, Eric, additional, Esposito, Felice, additional, Esser, Victoria, additional, Eugster, Erica A., additional, Farooqi, Sadaf, additional, Fassnacht, Martin, additional, Fauser, Bart C.J.M., additional, Fenzi, Gianfranco, additional, Ferrannini, Ele, additional, Findlay, David M., additional, Finlayson, Courtney, additional, Fisher, Delbert A., additional, Forest, Maguelone G., additional, Foster, Daniel W., additional, Freeman, Mason Wright, additional, Frydenberg, Mark, additional, Fuller, Peter, additional, Gagel, Robert F., additional, Gaglia, Jason L., additional, Galizia, Gianluigi, additional, Gao, Chuanyun, additional, Gardella, Thomas J., additional, Gaylinn, Bruce D., additional, Genant, Harry K., additional, German, Michael S., additional, Ghatei, Mohammad A., additional, Giudice, Linda C., additional, Glasier, Anna, additional, Glorieux, Francis H., additional, González-Maeso, Javier, additional, Gooren, Louis J., additional, Gordon, David F., additional, Gregerson, Karen A., additional, Gross, Milton D., additional, Grossman, Ashley, additional, Guimarães, Valéria C., additional, Gurnell, Mark, additional, Haddad, Nadine, additional, Haisenleder, Daniel J., additional, Handelsman, David J., additional, Hanks, John B., additional, Hannon, Mark John, additional, Hayward, Simon W., additional, Hebrok, Matthias, additional, Hegedüs, Laszlo, additional, Hennemann, Georg, additional, Herndon, Maria K., additional, Hindmarsh, Peter, additional, Ho, Ken K.Y., additional, Horseman, Nelson D., additional, Horwitz, Mara J., additional, Hu, Mimi, additional, Hughes, Ieuan A., additional, Hupfeld, Christopher J., additional, Hussain, Hero K., additional, Illingworth, Peter, additional, Jameson, J. Larry, additional, Josso, Nathalie, additional, Jüppner, Harald, additional, Kalish, Jeffrey, additional, Kaplan, Edwin L., additional, Kerr, Jeffrey B., additional, Klein, Ronald, additional, Knobel, Meyer, additional, Kolibianakis, Efstratios, additional, Kopchick, John J., additional, Kopp, Peter, additional, Korbonits, Márta, additional, Korobkin, Melvyn, additional, Krane, Stephen M., additional, Krohn, Knut, additional, Kronenberg, Henry M., additional, Kyriakis, John M., additional, Lau, Sue Lynn, additional, Lazarus, John H., additional, Learoyd, Diana L., additional, Lebovitz, Harold E., additional, Lee, Paul, additional, Lernmark, Åke, additional, Lewis-Tuffin, Laura J., additional, Lu, Zhi-Liang, additional, Macchia, Paolo Emidio, additional, Maclaren, Noel K., additional, Maenhaut, Carine, additional, Maes, Christa, additional, Main, Katharina M., additional, Malchoff, Carl D., additional, Malchoff, Diana Mark, additional, Malik, Rayaz A., additional, Mandel, Susan J., additional, Mantzoros, Christos, additional, Maratos-Flier, Eleftheria, additional, Marchisotta, Stefania, additional, Marinò, Michele, additional, Marshall, John C., additional, Martin, Thomas F.J., additional, Martin, T. John, additional, Martos-Moreno, Gabriel Á., additional, Mathias, Christopher J., additional, Mauer, Michael, additional, McGee, Elizabeth A., additional, McKenna, Neil J., additional, McLachlan, Robert I., additional, Medeiros-Neto, Geraldo, additional, Meier, Juris J., additional, Melmed, Shlomo, additional, Metzger, Boyd E., additional, Millar, Robert, additional, Miller, Walter L., additional, Misra, Madhusmita, additional, Molitch, Mark E., additional, Moore, David D., additional, Morris, Damian G., additional, Munck, Allan U., additional, Nakamoto, Jon, additional, Náray-Fejes-Tóth, Anikó, additional, Nass, Ralf, additional, Nathan, David M., additional, New, Maria I., additional, Nguyen, Carolyn, additional, Nieman, Lynnette K., additional, Nilson, John H., additional, Norton, Jeffrey A., additional, Oakley, Robert H., additional, Öberg, Kjell, additional, Olefsky, Jerrold M., additional, O’Rahilly, Stephen, additional, Ozcan, Umut, additional, Pacak, Karel, additional, Pacini, Furio, additional, Padia, Shetal H., additional, Paschke, Ralf, additional, Pawson, Adam, additional, Peck, Alison C., additional, Giraldi, Francesca Pecori, additional, Persani, Luca, additional, Phelps, Richard L., additional, Philipson, Louis H., additional, Phillips, Kevin, additional, Pinchera, Aldo, additional, Pomposelli, Frank B., additional, Potts, John T., additional, Quigley, Charmian A., additional, Quinkler, Marcus, additional, Quirk, Christine Campion, additional, Rademaker, Miriam T., additional, Meyts, Ewa Rajpert-De, additional, Ravussin, Eric, additional, Ray, David W., additional, Reame, Nancy King, additional, Refetoff, Samuel, additional, Retnakaran, Ravi, additional, Rey, Rodolfo A., additional, Rhodes, Christopher J., additional, Ridgway, E. Chester, additional, Risbridger, Gail P., additional, Rizza, Robert A., additional, Robinson, Bruce, additional, Roger, Pierre P., additional, Rosenfeld, Michael G., additional, Rosenfield, Robert L., additional, Rosing, James H., additional, Rossing, Peter, additional, Rubin, Robert T., additional, Ruderman, Neil, additional, Russo, Irma H., additional, Russo, Jose, additional, Salameh, Wael Antoine, additional, Salusky, Isidoro B., additional, Samuels, Mary H., additional, Santen, Richard J., additional, Santoro, Nanette, additional, Sarapura, Virginia D., additional, Sealfon, Stuart C., additional, Sexton, Patrick M., additional, Shulman, Gerald I., additional, Silva, Paolo S., additional, Silverberg, Shonni J., additional, Singer, Frederick R., additional, Skakkebaek, Niels E., additional, Skowronska-Krawczyk, Dorota, additional, Smith, Carolyn L., additional, Smith, Philip W., additional, Smith, Roger, additional, Smith, Steven R., additional, Snyder, Peter J., additional, Stanhope, Richard, additional, St-Arnaud, René, additional, Steiner, Donald F., additional, Stevens, Adam, additional, Stewart, Andrew F., additional, Stewart, Paul M., additional, St. Germain, Donald L., additional, Stockigt, Jim, additional, Strauss, Jerome F., additional, Swiersz, Lillian Marie, additional, Tacon, Lyndal J., additional, Taheri, Shahrad, additional, Thakker, Rajesh V., additional, Thompson, Chris, additional, Thorner, Michael O., additional, Timmers, Henri J.L.M., additional, Toppari, Jorma, additional, Traggiai, Cristina, additional, Traub, Michael L., additional, Tseng, Yolanda, additional, Turek, Fred W., additional, Van Cauter, Eve, additional, Van den Berghe, Greet, additional, Van Steirteghem, André C., additional, Vassart, Gilbert, additional, Vilain, Eric, additional, Visser, Theo J., additional, Wajnrajch, Michael P., additional, Wand, Gary, additional, Webb, Paul, additional, Weetman, Anthony P., additional, Weigel, Nancy L., additional, Weir, Gordon C., additional, Weiss, Roy E., additional, Wesseling-Perry, Katherine, additional, White, Anne, additional, White, Kenneth E., additional, White, Morris F., additional, Whyte, Michael P., additional, Wiersinga, Wilmar M., additional, Wolfsdorf, Joseph I., additional, and Zinman, Bernard, additional

Published
2010
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63. Contributors

Author

Alman, Benjamin A., primary, Arboleda, Valerie A., additional, Arnold, Andrew, additional, Bell, Graeme I., additional, Beckers, Albert M., additional, Bertagna, Xavier Y., additional, Bertherat, Jerome, additional, Christensen, Jane H., additional, Clément, Karine, additional, Cummings, Shelly A., additional, Daly, Adrian F., additional, Dittmar, Manuela, additional, Dreijerink, Koen M.A., additional, Dubern, Beatrice, additional, Dumitrescu, Alexandra, additional, Ehrmann, David A., additional, Ellard, Sian, additional, Evans, Douglas B., additional, Fagin, James A., additional, Fleming, Alice A., additional, Grasberger, Helmut, additional, Greeley, Siri A., additional, Groussin, Lionel, additional, Halsall, David J., additional, Hattersley, Andrew T., additional, Hoffman, Leslie, additional, Holick, Michael F., additional, Höppener, Jo W.M., additional, Hwa, Vivian, additional, Jimenez, Camilo, additional, Joseph, Loren, additional, Kahaly, George J., additional, Lauter, Kelly, additional, Layman, Lawrence C., additional, Libe, Rosella, additional, Lips, Cornelius J.M., additional, Van de Luijt, Rob B., additional, Mitsiades, Nicholas, additional, Murphy, Rinki, additional, van Nesselrooij, Bernadette P.M., additional, New, Maria I., additional, Nimkarn, Saroj, additional, O’Rahilly, Stephen, additional, Philipson, Louis H., additional, Pohlenz, Joachim, additional, Polonsky, Kenneth S., additional, Qin, Kenan, additional, Radovick, Sally, additional, Refetoff, Samuel, additional, Rich, Thereasa A., additional, Rittig, Soren, additional, Romero, Christopher J., additional, RosenfeLd, Ron G., additional, Savage, David B., additional, Semple, Robert K., additional, Stöy, Julie, additional, Stratakis, Constantine A., additional, Strauss, Bernard S., additional, Tounian, Patrick, additional, Vilain, Eric, additional, Vliet, Guy Van, additional, and Weiss, Roy E., additional

Published
2010
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67. Thyroid hormone and cardiac function in mice deficient in thyroid hormone receptor-[alpha] or -[beta]: an echocardiograph study

Author

Weiss, Roy E., Korcarz, Claudia, Chassande, Olivier, Cua, Kevin, Sadow, Peter M., Koo, Eugene, Samarut, Jacques, and Lang, Roberto

Subjects
Cytochemistry -- Research, Molecular biology -- Research, Thyroid hormones -- Physiological aspects, Mice -- Physiological aspects, Heart -- Physiological aspects, Echocardiography -- Usage, Biological sciences
Abstract

We investigated the effect of thyroid hormone (TH) receptor (TR)[alpha] and -[beta] isoforms in TH action in the heart. Noninvasive echocardiographic measurements were made in mice homozygous for disruption of TR[alpha] (TR[[alpha].sup.0/0]) or TR[beta] (TR[[beta].sup.-/-]). Mice were studied at baseline, 4 wk after TH deprivation (using a low-iodine diet containing propylthiouracil), and after 4-wk treatment with TH. Baseline heart rates (HR) were similar in wild-type (WT) and TR[[alpha].sup.0/0] mice but were greater in TR[[beta].sup.-/-] mice. With TH deprivation, HR decreased 49% in WT and 37% in TR[[beta].sup.-/-] mice and decreased only 5% in TR[[alpha]0/0] mice from baseline, whereas HR increased in all genotypes with TH treatment. Cardiac output (CO) and cardiac index (CI) in WT mice decreased (-31 and -32%, respectively) with TH deprivation and increased (+69 and +35%, respectively) with TH treatment. The effects of CO and CI were blunted with TH withdrawal in both TR[[alpha]0/0] (+8 and -2%, respectively) and TR[[beta].sup.-/-] mice (-17 and -18%, respectively). Treatment with TH resulted in a 64% increase in LV mass in WT and a 44% increase in TR[[alpha].sup.0/0] mice but only a 6% increase in TR[[beta].sup.-/-] mice (ANOVA P < 0.05). Taken together, these data suggest that TR[alpha] and TR[beta] play different roles in the physiology of TH action on the heart. left ventricular mass; thyrotropin; cardiac index; cardiac output; shortening fraction

Published
2002

69. Contributors

Author

Adler, Suzanne Myers, primary, Ain, Kenneth B., additional, Ball, Douglas W., additional, Beck-Peccoz, Paolo, additional, Bianco, Antonio C., additional, Brent, Gregory, additional, Burman, Kenneth D., additional, Busaidy, Naifa L., additional, Caturegli, Patrizio, additional, Cohen, Ronald N., additional, Davies, Terry F., additional, De Felice, Mario, additional, Di Lauro, Roberto, additional, Dumitrescu, Alexandra M., additional, Foley, Thomas P., additional, Gaillard, Stéphanie, additional, Grueters-Kieslich, Annette, additional, Hashimoto, Koshi, additional, Haugen, Bryan R., additional, Hershman, Jerome M., additional, Hollander, Jason M., additional, Hollenberg, Anthony N., additional, Kim, Brian W., additional, Kloos, Richard T., additional, Koenig, Ronald J., additional, Kopp, Peter, additional, Ladenson, Paul W., additional, Landek, Melissa, additional, Léger, Juliane, additional, Nakhla, Meranda, additional, Peloquin, Joanna M., additional, Persani, Luca, additional, Refetoff, Samuel, additional, Rovet, Joanne F., additional, Sabet, Amin, additional, Said, Sherif, additional, Satoh, Tetsuro, additional, Schroeder, Pamela R., additional, Sidhaye, Aniket, additional, Solis-S, Juan Carlos, additional, Tan, Emily J., additional, Tran, Neil, additional, Van Vliet, Guy, additional, Weiss, Roy E., additional, Wondisford, Fredric E., additional, Yamada, Masanobu, additional, and Yen, Paul M., additional

Published
2009
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70. RXR receptor agonist suppression of thyroid function: central effects in the absence of thyroid hormone receptor

Author

Macchia, Paolo E., Jiang, Ping, Yuan, Yan-Dar, Chandarardna, Roshantha A.S., Weiss, Roy E., Chassande, Olivier, Samarut, Jacques, Refetoff, Samuel, and Burant, Charles F.

Subjects
Tretinoin -- Physiological aspects, Hyperglycemia -- Physiological aspects, Diabetes -- Physiological aspects, Hypothyroidism -- Physiological aspects, Biological sciences
Abstract

High-affinity agonists for the retinoic acid X receptors (RXR) have pleotropic effects when administered to humans. These include induction of hypertriglyceridemia and hypothyroidism. We determined the effect of a novel high-affinity RXR agonist with potent antihyperglycemic effects on thyroid function of female Zucker diabetic rats and nondiabetic littermates and in db/db mice. In both nondiabetic and ZFF rats, AGN194204 causes a 70-80% decrease in thyrotropin (TSH), 3,3',5-triiodothyronine, and thyroxine ([T.sub.4]) concentrations. In the db/db mouse, AGN194204 causes a time-dependent decrease in thyroid hormone levels with the fall in TSH that was significant after 1 day of treatment preceding the fall in [T.sub.4] levels that was significant at 3 days of treatment. Treatment with AGN194204 caused an initial increase in hepatic 5'-deiodinase mRNA levels which then fell to undetectable levels by 3 days of treatment and continued to be low at 7 days of treatment. After treatment for 5 days with AGN194204, both wild-type and thyroid hormone receptor (TR[[beta].sup.-/-])-deficient mice demonstrated a nearly 50% decrease in serum TSH and [T.sub.4] concentrations. The results suggest that a high-affinity RXR agonist with antihyperglycemic activity can cause central hypothyroidism independently of TR[beta], the main mediator of hormone-induced TSH suppression. nuclear receptors; retinoic acid receptors; hypothyroidism; knockout mice

Published
2002

71. Mifepristone, a Glucocorticoid Receptor Antagonist, Produces Clinical and Metabolic Benefits in Patients with Cushingʼs Syndrome

Author

Fleseriu, Maria, Biller, Beverly M. K., Findling, James W., Molitch, Mark E., Schteingart, David E., Gross, Coleman, Auchus, Richard, Bailey, Timothy, Biller, Beverly M. K., Carroll, Ty, Colleran, Kathleen, Fein, Henry, Findling, James W., Fleseriu, Maria, Hamrahian, Amir, Katznelson, Laurence, Kerr, Janice, Kipnes, Mark, Kirschner, Lawrence, Koch, Christian, Lerman, Sam, Lyons, Timothy, McPhaul, Michael, Molitch, Mark E., Schteingart, David E., Vaughan, T. Brooks, III, and Weiss, Roy

Published
2012

79. Clinical and Molecular Analysis in 2 Families With Novel Compound Heterozygous SBP2 (SECISBP2) Mutations

Author

Fu, Jiao, primary, Korwutthikulrangsri, Manassawee, additional, Gönç, E Nazli, additional, Sillers, Laura, additional, Liao, Xiao-Hui, additional, Alikaşifoğlu, Ayfer, additional, Kandemir, Nurgün, additional, Menucci, Maria Belen, additional, Burman, Kenneth D, additional, Weiss, Roy E, additional, and Dumitrescu, Alexandra M, additional

Published
2020
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