71 results on '"Wensing, A. M.J."'
Search Results
52. Immunogenicity of influenza vaccines: Evidence for differential effect of secondary vaccination on humoral and cellular immunity
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MMB Diagnostische Laboratoria, UMC Utrecht, MMB opleiding Arts microbioloog, Infection & Immunity, Huber, Sietske K.Rosendahl, Hendriks, Marion, Jacobi, Ronald H.J., Van De Kassteele, Jan, Mandersloot-Oskam, Jolanda C., Van Boxtel, Renée A.J., Wensing, Anne M.J., Rots, Nynke Y., Luytjes, Willem, Van Beek, Josine, MMB Diagnostische Laboratoria, UMC Utrecht, MMB opleiding Arts microbioloog, Infection & Immunity, Huber, Sietske K.Rosendahl, Hendriks, Marion, Jacobi, Ronald H.J., Van De Kassteele, Jan, Mandersloot-Oskam, Jolanda C., Van Boxtel, Renée A.J., Wensing, Anne M.J., Rots, Nynke Y., Luytjes, Willem, and Van Beek, Josine
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- 2019
53. REtrieval And cure of Chronic Hepatitis C (REACH): Results of micro-elimination in the Utrecht province
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MS Infectieziekten, MS Interne Geneeskunde, Infection & Immunity, MS MDL 1, Cancer, MMB opleiding Arts microbioloog, MMB Medische Staf, MMB Staf diagnostiek, Circulatory Health, Kracht, Patricia A.M., Arends, Joop E., van Erpecum, Karel J., Thijsen, Steven F.T., Vlaminckx, Bart J.M., Weersink, Annemarie J.L., Wensing, Anne M.J., Deege, Marjolein P.H., Dimmendaal, Marieke, Stadhouders, Paul H.G.M., Friederich, Philip W., Verhagen, Marc A.M.T., Boland, Greet J., Hoepelman, Andy I.M., MS Infectieziekten, MS Interne Geneeskunde, Infection & Immunity, MS MDL 1, Cancer, MMB opleiding Arts microbioloog, MMB Medische Staf, MMB Staf diagnostiek, Circulatory Health, Kracht, Patricia A.M., Arends, Joop E., van Erpecum, Karel J., Thijsen, Steven F.T., Vlaminckx, Bart J.M., Weersink, Annemarie J.L., Wensing, Anne M.J., Deege, Marjolein P.H., Dimmendaal, Marieke, Stadhouders, Paul H.G.M., Friederich, Philip W., Verhagen, Marc A.M.T., Boland, Greet J., and Hoepelman, Andy I.M.
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- 2019
54. Impact of the HIV-1 genetic background and HIV-1 population size on the evolution of raltegravir resistance
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Fun, Axel, Leitner, Thomas, Vandekerckhove, Linos, Däumer, Martin, Thielen, Alexander, Buchholz, Bernd, Hoepelman, Andy I.M., Gisolf, Elizabeth H., Schipper, Pauline J., Wensing, Annemarie M.J., Nijhuis, Monique, Fun, Axel, Leitner, Thomas, Vandekerckhove, Linos, Däumer, Martin, Thielen, Alexander, Buchholz, Bernd, Hoepelman, Andy I.M., Gisolf, Elizabeth H., Schipper, Pauline J., Wensing, Annemarie M.J., and Nijhuis, Monique
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- 2018
55. Effect of HIV-1 low-level viraemia during antiretroviral therapy on treatment outcomes in WHO-guided South African treatment programmes : A multicentre cohort study
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Hermans, Lucas E., Moorhouse, Michelle, Carmona, Sergio, Grobbee, Diederick E., Hofstra, L. Marije, Richman, Douglas D., Tempelman, Hugo A., Venter, Willem D.F., Wensing, Annemarie M.J., Hermans, Lucas E., Moorhouse, Michelle, Carmona, Sergio, Grobbee, Diederick E., Hofstra, L. Marije, Richman, Douglas D., Tempelman, Hugo A., Venter, Willem D.F., and Wensing, Annemarie M.J.
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- 2018
56. Effect of HIV-1 low-level viraemia during antiretroviral therapy on treatment outcomes in WHO-guided South African treatment programmes: A multicentre cohort study
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UMC Utrecht, MMB Research line 3b, Infection & Immunity, MMB Research line 3a, Cardiovasculaire Epi Team 9, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MMB opleiding Arts microbioloog, Divisieleiding, MMB Medische Staf, Hermans, Lucas E., Moorhouse, Michelle, Carmona, Sergio, Grobbee, Diederick E., Hofstra, L. Marije, Richman, Douglas D., Tempelman, Hugo A., Venter, Willem D.F., Wensing, Annemarie M.J., UMC Utrecht, MMB Research line 3b, Infection & Immunity, MMB Research line 3a, Cardiovasculaire Epi Team 9, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MMB opleiding Arts microbioloog, Divisieleiding, MMB Medische Staf, Hermans, Lucas E., Moorhouse, Michelle, Carmona, Sergio, Grobbee, Diederick E., Hofstra, L. Marije, Richman, Douglas D., Tempelman, Hugo A., Venter, Willem D.F., and Wensing, Annemarie M.J.
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- 2018
57. Factors associated with presenting late or with advanced HIV disease in the Netherlands, 1996-2014: results from a national observational cohort
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Op De Coul, Eline L.M., Van Sighem, Ard, Brinkman, Kees, Van Benthem, Birgit H., Van Der Ende, Marchina E., Geerlings, Suzanne, Reiss, Peter, Prins, J. M., Kuijpers, T. W., Scherpbier, H. J., Van Der Meer, J. T.M., Wit, F.W.N.M., Godfried, M. H., Reiss, P., Van Der Poll, T., Nellen, F. J.B., Geerlings, S. E., Van Vugt, M., Pajkrt, D., Bos, J. C., Wiersinga, W. J., Van Der Valk, M., Goorhuis, A., Hovius, J. W., Van Eden, J., Henderiks, A., Van Hes, A. M.H., Mutschelknauss, M., Nobel, H. E., Pijnappel, F. J.J., Westerman, A. M., Jurriaans, S., Back, N. K.T., Zaaijer, H. L., Berkhout, B., Cornelissen, M. T.E., Schinkel, C. J., Thomas, X. V., De Ruyter Ziekenhuis, Admiraal, Van Den Berge, M., Stegeman, A., Baas, S., De Looff, L. Hage, Versteeg, D., Pronk, M. J.H., Ammerlaan, H. S.M., Korsten-Vorstermans, E. M.H.M., De Munnik, E. S., Tjhie, J., Wegdam, M. C.A., Weijsenfeld, A. M., Van Der Ende, M. E., De Vries-Sluijs, T. E.M.S., Van Gorp, E. C.M., Schurink, C. A.M., Nouwen, J. L., Verbon, A., Rijnders, B. J.A., Bax, H. I., Hassing, R. J., Van Der Feltz, M., Bassant, N., Van Beek, J. E.A., Vriesde, M., Van Zonneveld, L. M., De Oude-Lubbers, A., Van Den Berg-Cameron, H. J., Bruinsma-Broekman, F. B., De Groot, J., De Zeeuw-De Man, M., Broekhoven-Kruijne, M. J., Schutten, M., Osterhaus, A. D.M.E., Boucher, C. A.B., Driessen, G. J.A., Van Rossum, A. M.C., Van Der Knaap, L. C., Visser, E., Branger, J., Duijf-Van De Ven, C. J.H.M., Schippers, E. F., Van Nieuwkoop, C., Brimicombe, R. W., VanJperen, J. M., Van Der Hut, G., Franck, P. F.H., Van Eeden, A., Groot, M., Kwa, I. S., Bouwhuis, J. W., Van Hulzen, A. G.W., Bor, P. C.J., Bloembergen, P., Wolfhagen, M. J.H.M., Ruijs, G. J.H.M., Soetekouw, R., Van Der Prijt, L. M.M., Schoemaker, M., Van Der Reijden, W. A., Jansen, R., Herpers, B. L., Kroon, F. P., Arend, S. M., De Boer, M. G.J., Bauer, M. P., Jolink, H., Vollaard, A. M., Moons, C., Kroes, A. C.M., Pogany, K., Smit, J. V., Smit, E., Van Niekerk, T., Pontesilli, O., Lashof, A. Oude, Posthouwer, D., Schippers, J., Vergoossen, R., Loo, I. H., El Moussaoui, R., Van Twillert, G., Stuart, J. W.T.Cohen, Diederen, B. M.W., Van Truijen-Oud, F. A., Gelinck, L. B.S., Meerkerk, C., Wildenbeest, G. S., Jansen, C. L., Van Houte, D. P.F., Faber, S., Delsing, C. E., Heins, H., Frissen, P. H.J., Blok, W. L., Schouten, W. E.M., Van Den Berk, G. E.L., Brouwer, C. J., Geerders, G. F., Hoeksema, K., Kleene, M. J., Van Der Meché, I. B., Toonen, A. J.M., Wijnands, S., Keuter, M., Van Der Ven, A. J.A.M., Hofstede, Hjm Ter, Dofferhoff, A. S.M., Van Crevel, R., Bosch, M. E.W., Grintjes-Huisman, K. J.T., Zomer, B. J., Van Der Berg, J. P., Gisolf, E. H., Van Bentum, P. H.M., Langebeek, N., Swanink, C. M.A., Lettinga, K. D., Sulman, H., Witte, E., Vrouenraets, S. M.E., Lauw, F. N., Paap, H., Vlasblom, D. J., Rosingh, A. W., Brouwer, A. E., Kuipers, M., Santegoets, R. M.W.J., Van Der Ven, B., Buiting, A. G.M., Kabel, P. J., Sprenger, H. G., Scholvinck, E. H., Van Assen, S., Wilting, K. R., Stienstra, Y., Van Der Meulen, P. A., De Weerd, D. A., Riezebos-Brilman, A., Van Leer-Buter, C. C., Schneider, M. M.E., Mudrikova, T., Ellerbroek, P. M., Oosterheert, J. J., Arends, J. E., Barth, R. E., Wassenberg, M. W.M., Laan, L. M., Van Oers-Hazelzet, E. E.B., Patist, J., Vervoort, S., Frauenfelder, R., Verduyn-Lunel, F., Wensing, A. M.J., Van Agtmael, M. A., Perenboom, R. M., Bomers, M., De Vocht, J., Vandenbroucke-Grauls, C. M.J.E., Ang, C. W., Wolfs, T. F.W., Bont, L. J., Gras, L., Van Sighem, A. I., Smit, C., Hillebregt, M., Kimmel, V., Tong, Y., Van Den Boogaard, R., Hoekstra, P., De Lang, A., Berkhout, M., Grivell, S., Jansen, A., Van Den Akker, M., Bergsma, D., Lodewijk, C., Meijering, R., Peeck, B., Raethke, M., Ree, C., Regtop, R., Ruijs, Y., Schoorl, M., Tuijn, E., Veenenberg, L., Woudstra, T., Bakker, Y., De Jong, A., Broekhoven, M., Claessen, E., Rademaker, M. J., Munjishvili, L., Kruijne, E., Other departments, AII - Amsterdam institute for Infection and Immunity, APH - Amsterdam Public Health, Infectious diseases, Global Health, Paediatric Infectious Diseases / Rheumatology / Immunology, General Internal Medicine, Center of Experimental and Molecular Medicine, Graduate School, Medical Microbiology and Infection Prevention, Gastroenterology and Hepatology, APH - Health Behaviors & Chronic Diseases, Internal Medicine, Virology, Medical Microbiology & Infectious Diseases, Epidemiology, Pediatric Surgery, Pediatrics, Med Microbiol, Infect Dis & Infect Prev, MUMC+: MA Alg Interne Geneeskunde (9), MUMC+: DA MMI Staf (9), RS: CAPHRI - R4 - Health Inequities and Societal Participation, RS: NUTRIM - R3 - Chronic inflammatory disease and wasting, MUMC+: DA Medische Microbiologie en Infectieziekten (5), MUMC+: DA MMI Infectieserologie (9), and MUMC+: DA MMI AIOS (9)
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Male ,Pediatrics ,Delayed Diagnosis ,Epidemiology ,General Practice ,Health Behavior ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,HIV Infections ,Logistic regression ,Cohort Studies ,0302 clinical medicine ,Risk Factors ,Ethnicity ,030212 general & internal medicine ,Young adult ,Netherlands ,Transients and Migrants ,Age Factors ,Prenatal Care ,General Medicine ,Middle Aged ,Hospitals ,Cohort ,Disease Progression ,Female ,0305 other medical science ,Sexuality ,Cohort study ,Adult ,medicine.medical_specialty ,Emigrants and Immigrants ,Prenatal care ,03 medical and health sciences ,Young Adult ,Acquired immunodeficiency syndrome (AIDS) ,SDG 3 - Good Health and Well-being ,medicine ,Humans ,Socioeconomic status ,030505 public health ,business.industry ,Research ,medicine.disease ,lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] ,business ,Demography - Abstract
Contains fulltext : 172538.pdf (Publisher’s version ) (Open Access) OBJECTIVES: Early testing for HIV and entry into care are crucial to optimise treatment outcomes of HIV-infected patients and to prevent spread of HIV. We examined risk factors for presentation with late or advanced disease in HIV-infected patients in the Netherlands. METHODS: HIV-infected patients registered in care between January 1996 and June 2014 were selected from the ATHENA national observational HIV cohort. Risk factors for late presentation and advanced disease were analysed by multivariable logistic regression. Furthermore, geographical differences and time trends were examined. RESULTS: Of 20 965 patients, 53% presented with late-stage HIV infection, and 35% had advanced disease. Late presentation decreased from 62% (1996) to 42% (2013), while advanced disease decreased from 46% to 26%. Late presentation only declined significantly among men having sex with men (MSM; p /=50 years (1.46; CI 1.33 to 1.60 vs 30-49 years), region of origin (South-East Asia 2.14; 1.80 to 2.54, sub-Saharan Africa 2.11; 1.88 to 2.36, Surinam 1.59; 1.37 to 1.84, Caribbean 1.31; 1.13 to 1.53, Latin America 1.23; 1.04 to 1.46 vs the Netherlands), and location of HIV diagnosis (hospital 3.27; 2.94 to 3.63, general practitioner 1.66; 1.50 to 1.83, antenatal screening 1.76; 1.38 to 2.34 vs sexually transmitted infection clinic). No association was found for socioeconomic status or level of urbanisation. Compared with Amsterdam, 2 regions had higher adjusted odds and 2 regions had lower odds of late presentation. Results were highly similar for advanced disease. CONCLUSIONS: Although the overall rate of late presentation is declining in the Netherlands, targeted programmes to reduce late HIV diagnoses remain needed for all risk groups, but should be prioritised for heterosexual males, migrant populations, people aged >/=50 years and certain regions in the Netherlands.
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- 2016
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58. HIV protease inhibitor resistance
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Wensing, Annemarie M.J., Fun, Axel, Nijhuis, Monique, Wensing, Annemarie M.J., Fun, Axel, and Nijhuis, Monique
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- 2017
59. High rates of transmission of drug-resistant HIV in Aruba resulting in reduced susceptibility to the WHO recommended first-line regimen in nearly half of newly diagnosed HIV-infected patients
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Hofstra, L. Marije, Rivas, Elena Sánchez, Nijhuis, Monique, Bank, Leonie E.A., Wilkinson, Eduan, Kelly, Karina, Mudrikova, Tania, Schuurman, Rob, De Oliveira, Tulio, De Kort, Jaclyn, Wensing, Annemarie M.J., Hofstra, L. Marije, Rivas, Elena Sánchez, Nijhuis, Monique, Bank, Leonie E.A., Wilkinson, Eduan, Kelly, Karina, Mudrikova, Tania, Schuurman, Rob, De Oliveira, Tulio, De Kort, Jaclyn, and Wensing, Annemarie M.J.
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- 2017
60. Viral reactivations and associated outcomes in the context of immune reconstitution after pediatric hematopoietic cell transplantation
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UMC Utrecht, Infection & Immunity, CTI Nierkens, SCT patientenzorg, Child Health, Haematologie, Regenerative Medicine and Stem Cells, MMB Medische Staf, Haematologie patientenzorg, Infectieziekten patientenzorg, CTI Lab support, Admiraal, Rick, de Koning, Coco C.H., Lindemans, Caroline A., Bierings, Marc B., Wensing, Annemarie M.J., Versluys, A. Birgitta, Wolfs, Tom F.W., Nierkens, Stefan, Boelens, Jaap Jan, UMC Utrecht, Infection & Immunity, CTI Nierkens, SCT patientenzorg, Child Health, Haematologie, Regenerative Medicine and Stem Cells, MMB Medische Staf, Haematologie patientenzorg, Infectieziekten patientenzorg, CTI Lab support, Admiraal, Rick, de Koning, Coco C.H., Lindemans, Caroline A., Bierings, Marc B., Wensing, Annemarie M.J., Versluys, A. Birgitta, Wolfs, Tom F.W., Nierkens, Stefan, and Boelens, Jaap Jan
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- 2017
61. HIV protease inhibitor resistance
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MMB KAM, UMC Utrecht, Infection & Immunity, Wensing, Annemarie M.J., Fun, Axel, Nijhuis, Monique, MMB KAM, UMC Utrecht, Infection & Immunity, Wensing, Annemarie M.J., Fun, Axel, and Nijhuis, Monique
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- 2017
62. High rates of transmission of drug-resistant HIV in Aruba resulting in reduced susceptibility to the WHO recommended first-line regimen in nearly half of newly diagnosed HIV-infected patients
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MMB opleiding Arts microbioloog, MMB Research line 3a, MS Interne Geneeskunde, Infection & Immunity, MMB Staf diagnostiek, MMB Medische Staf, Hofstra, L. Marije, Rivas, Elena Sánchez, Nijhuis, Monique, Bank, Leonie E.A., Wilkinson, Eduan, Kelly, Karina, Mudrikova, Tania, Schuurman, Rob, De Oliveira, Tulio, De Kort, Jaclyn, Wensing, Annemarie M.J., MMB opleiding Arts microbioloog, MMB Research line 3a, MS Interne Geneeskunde, Infection & Immunity, MMB Staf diagnostiek, MMB Medische Staf, Hofstra, L. Marije, Rivas, Elena Sánchez, Nijhuis, Monique, Bank, Leonie E.A., Wilkinson, Eduan, Kelly, Karina, Mudrikova, Tania, Schuurman, Rob, De Oliveira, Tulio, De Kort, Jaclyn, and Wensing, Annemarie M.J.
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- 2017
63. Acute influenza virus-associated encephalitis and encephalopathy in adults:A challenging diagnosis
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Meijer, Wouter J., Linn, Francisca H.H., Wensing, Anne M.J., Leavis, Helen L., van Riel, Debby, GeurtsvanKessel, Corine H., Wattjes, Mike P., Murk, Jean Luc, Meijer, Wouter J., Linn, Francisca H.H., Wensing, Anne M.J., Leavis, Helen L., van Riel, Debby, GeurtsvanKessel, Corine H., Wattjes, Mike P., and Murk, Jean Luc
- Abstract
Background: Acute influenza-associated encephalopathy/encephalitis (IAE) in adults is a rare but well-known complication of influenza virus infection. The diagnosis is difficult to make due to the absence of distinctive clinical symptoms and validated diagnostic criteria. We present an illustrative case and a case review on acute IAE in adults. Methods: We performed a Medline search of the English literature using the terms influenz*, encephal* and adult, and constructed a database of detailed descriptions of patients with influenza virus infection with influenza-like symptoms at the onset of neurological symptoms. Results: A total of 44 patients were included. Confusion and seizures were the most prevalent neurological symptoms, present in 12 (27%) and 10 (23%) patients, respectively. Magnetic resonance imaging (MRI) was performed in 21 patients and anomalies were found in 13 (62%), with lesions located throughout the brain. Influenza virus RNA was detected in cerebrospinal fluid (CSF) in 5 (16%) of 32 patients. Eight (18%) of the forty-four patients died. The benefits of antiviral and immunomodulatory therapy have not been well studied. Discussion: Our results show that many different neurological symptoms can be present in patients with acute onset IAE. Therefore, the diagnosis should be considered in patients with fever and neurological symptoms, especially during the influenza season. Laboratory diagnosis consists of demonstration of influenza virus RNA in brain tissue, CSF or respiratory samples, and demonstration of intrathecal antibody production against influenza virus. The presence of brain lesions in MRI and influenza virus in CSF appear to be of prognostic value.
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- 2016
64. HIV-1 drug-resistance patterns among patients on failing treatment in a large number of European countries
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Van De Vijver, David A.M.C., Wensing, Annemarie M.J., Åsjö, Birgitta, Bruckova, Marie, Jorgensen, Louise Bruun, Camacho, Ricardo, Horban, Andrzej, Linka, Marek, Lazanas, Marios, Loveday, Clive, MacRae, Eilidh, Nielsen, Claus, Paraskevis, Dimitrios, Poljak, Mario, Puchhammer-Stöckl, Elisabeth, Ruiz, Lidia, Schmit, Jean Claude, Stanczak, Grzegorz, Stanojevic, Maja, Vandamme, Anne Mieke, Vercauteren, Jurgen, Zazzi, Maurizio, Bacheler, Lee, Lecocq, Pierre, Villacian, Jorge, Boucher, Charles A.B., Van De Vijver, David A.M.C., Wensing, Annemarie M.J., Åsjö, Birgitta, Bruckova, Marie, Jorgensen, Louise Bruun, Camacho, Ricardo, Horban, Andrzej, Linka, Marek, Lazanas, Marios, Loveday, Clive, MacRae, Eilidh, Nielsen, Claus, Paraskevis, Dimitrios, Poljak, Mario, Puchhammer-Stöckl, Elisabeth, Ruiz, Lidia, Schmit, Jean Claude, Stanczak, Grzegorz, Stanojevic, Maja, Vandamme, Anne Mieke, Vercauteren, Jurgen, Zazzi, Maurizio, Bacheler, Lee, Lecocq, Pierre, Villacian, Jorge, and Boucher, Charles A.B.
- Abstract
Background: Information about patterns of HIV-1 drug resistance among treatment-exposed patients is crucial for the development of novel effective drugs. Currently no system exists that monitors patterns of resistance in patients failing therapy. Methods: The study included 1,988 HIV-1 sequences from patients experiencing therapy failure collected between 2000 and 2004 in 15 European countries. Genotypic resistance was interpreted using the ANRS algorithm. Phenotypic resistance was predicted using the Virco geno- to phenotype system. Results: 80.7% of the sequences included at least one drug-resistance mutation. Mutations were found for NRTIs (73.5%), NNRTIs (48.5%), and protease inhibitors (35.8%). Ninety percent of sequences with genotypic resistance harbored M184V, M41L, K103N, D67N, and/or T215Y. Among NRTIs, resistance was most frequently predicted for lamivudine. About half of all sequences had reduced susceptibility for NNRTIs. Resistance to most boosted protease inhibitors was found in < 25%. No sequence had resistance to all currently available drugs. Conclusion: Levels of resistance among patients with therapy failure were high. The patterns of resistance reflect resistance to drugs available for a longer time. Fully suppressive regimens can be designed even for the most mutated HIV because boosted protease inhibitors have remained active against most circulating viruses and new drug classes have become available.
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- 2010
65. Transmission of drug-resistant HIV-1 in Europe remains limited to single classes
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Wensing, Annemarie M.J., Vercauteren, Jurgen, Van De Vijver, David A., Albert, Jan, Åsjö, Birgitta, Balotta, Claudia, Camacho, Ricardo, Coughlan, Suzie, Grossman, Zehava, Horban, Andrzej, Kücherer, Claudia, Nielsen, Claus, Paraskevis, Dimitris, Loke, Wei C., Poggensee, Gabrielle, Puchhammer-Stöckl, Elisabeth, Riva, Chiara, Ruiz, Lidia, Schmit, Jean Claude, Schuurman, Rob, Salminen, Mika, Sonnerborg, Anders, Stanojevic, Maja, Struck, Daniel, Vandamme, Anne Mieke, Boucher, Charles A.B., Wensing, Annemarie M.J., Vercauteren, Jurgen, Van De Vijver, David A., Albert, Jan, Åsjö, Birgitta, Balotta, Claudia, Camacho, Ricardo, Coughlan, Suzie, Grossman, Zehava, Horban, Andrzej, Kücherer, Claudia, Nielsen, Claus, Paraskevis, Dimitris, Loke, Wei C., Poggensee, Gabrielle, Puchhammer-Stöckl, Elisabeth, Riva, Chiara, Ruiz, Lidia, Schmit, Jean Claude, Schuurman, Rob, Salminen, Mika, Sonnerborg, Anders, Stanojevic, Maja, Struck, Daniel, Vandamme, Anne Mieke, and Boucher, Charles A.B.
- Abstract
BACKGROUND: The spread of drug-resistant HIV-1 might compromise the future success of current first-line regimens. OBJECTIVE: To analyse the extent and impact of transmission of drug-resistant HIV-1 variants in Europe. DESIGN AND METHODS: The European prospective programme (SPREAD) collected demographic, clinical and virological data from 1245 HIV-1-infected individuals in 17 countries diagnosed in 2002-2003. The potential impact of transmitted drug resistance mutations (TDRMs) on therapy response was determined by using genotypic interpretation algorithms. RESULTS: The overall prevalence of viruses with drug-resistance mutations was 9.1% [96/1050; 95% confidence interval: 7.5-11.1]. The majority (71%) harboured only a single amino acid substitution with limited effect on predicted drug susceptibility. Mutations associated with resistance to nucleoside reverse transcriptase inhibitors were observed most frequently [57/1050 (5.4%)], followed by mutations related to protease inhibitors [32/1050 (3.0%)] and mutations related to non-nucleoside reverse transcriptase inhibitors (NNRTIs) [27/1050 (2.6%)].In some cases, however, resistance was quite extensive. Four individuals were infected with viruses with reduced susceptibility to all nucleoside reverse transcriptase inhibitors, 3 to all protease inhibitors and 20 to both NNRTIs. Remarkably, in one individual, the resistance pattern was so extensive that none of the available current antiretroviral drugs was predicted to be fully active. CONCLUSION: The prevalence of TDRM-HIV is quite prominent (9.1%) but did not increase in comparison with a large retrospective European study. Particularly the presence of single NNRTI mutations may impact the efficacy of the first-line regimens. Continuous prospective monitoring remains indicated to explore the patterns and factors contributing to the transmission of TDRMs as well as the potential clinical consequences.
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- 2008
66. An automated genotyping system for analysis of HIV-1 and other microbial sequences
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de Oliveira, Tulio, Deforche, Koen, Cassol, Sharon, Salminen, Mika, Paraskevis, Dimitris, Seebregts, Chris, Snoeck, Joe, van Rensburg, Estrelita Janse, Wensing, Annemarie M.J., van de Vijver, David A., Boucher, Charles A., Camacho, Ricardo, Vandamme, Anne Mieke, de Oliveira, Tulio, Deforche, Koen, Cassol, Sharon, Salminen, Mika, Paraskevis, Dimitris, Seebregts, Chris, Snoeck, Joe, van Rensburg, Estrelita Janse, Wensing, Annemarie M.J., van de Vijver, David A., Boucher, Charles A., Camacho, Ricardo, and Vandamme, Anne Mieke
- Abstract
Motivation: Genetic analysis of HIV-1 is important not only for vaccine development, but also to guide treatment strategies, track the emergence of new viral variants and ensure that diagnostic assays are contemporary and fully optimized. However, most genotyping methods are laborious and complex, and involve the use of multiple software applications. Here, we describe the development of an automated genotyping system that can be easily applied to HIV-1 and other rapidly evolving viral pathogens. Results: The new REGA subtyping tool, developed using Java programming and PERL scripts, combines phylogenetic analyses with bootscanning methods for the genetic subtyping of full-length and subgenomic fragments of HIV-1. When used to investigate the subtype of previously published reference datasets that were analysed using manual phylogenetic methods, the automated method correctly identified 97.5-100% of non-recombinant and circulating recombinant forms of HIV-1, including 108 full-length, 108 gag and 221 env sequences downloaded from the Los Alamos database.
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- 2005
67. HIV population genotypic tropism testing and its clinical significance
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Obermeier, Martin, primary, Symons, Jori, additional, and Wensing, Annemarie M.J., additional
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- 2012
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68. HIV co-receptor tropism
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Kaiser, Rolf, primary and Wensing, Annemarie M.J., additional
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- 2012
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69. Long-term complications in patients with poor immunological recovery despite virological successful HAART in Dutch ATHENA cohort
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Lelyveld, Steven F.L. van, Gras, Luuk, Kesselring, Anouk, Zhang, Shuangjie, De Wolf, Frank, Wensing, Annemarie M.J., and Hoepelman, Andy I.M.
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We investigated the risk of AIDS and serious non-AIDS-defining diseases (non-ADDs) according to the degree of immunological recovery after 2 years of virological successful antiretroviral therapy (HAART).
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- 2012
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70. Editorial introductions.
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Hicks, Charles, Martínez, Esteban, Wensing, Annemarie M.J., and Kaiser, Rolf
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- 2012
- Full Text
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71. Increase in transmitted resistance to non-nucleoside reverse transcriptase inhibitors among newly diagnosed HIV-1 infections in Europe
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Moutschen, M., Frentz, D., Van de Vijver, D. A. M. C., Abecasis, A. B., Albert, Jan, Hamouda, O., Jørgensen, L. B., Ku¨cherer, C., Struck, D., Schmit, J. -C, Vercauteren, J., A˚sjo¨, B., Balotta, Claudia, Beshkov, Danail, Camacho, Ricardo J., Clotet, B., Coughlan, S., Griskevicius, A., Grossman, Z., Horban, A., Kolupajeva, T., Korn, K., Kostrikis, Leontios G., Liitsola, K., Linka, M., Nielsen, C., Otelea, D., Paraskevis, Dimitrios N., Paredes, R., Poljak, M., Puchhammer, Stockl E., So¨nnerborg, A., Stanekova, D., Stanojevic, M., Van Wijngaerden, E., Wensing, A. M. J., Boucher, C. A. B., Sarcletti, M., Schmied, B., Geit, M., Balluch, G., Vandamme, A. -M, Derdelinckx, I., Sasse, A., Bogaert, M., Ceunen, H., De Roo, A., De Wit, S., Echahidi, F., Fransen, K., Goffard, J. -C, Goubau, P., Goudeseune, E., Yombi, J. -C, Lacor, P., Liesnard, C., Pierard, D., Rens, R., Schrooten, Y., Vaira, D., Vandekerckhove, L. P. R., Van den Heuvel, A., Van Der Gucht, B., Van Ranst, M., Vandercam, B., Vekemans, M., Verhofstede, C., Clumeck, N., Van Laethem, K., Demetriades, Ioannis, Kousiappa, Ioanna, Demetriou, Victoria L., Hezka, Johana, Bruckova, M., Machala, L., Gerstoft, J., Mathiesen, L., Pedersen, C., Nielsen, H., Laursen, A., Kvinesdal, B., Salminen, M., Ristola, M., Suni, J., Sutinen, J., Berg, T., Braun, P., Poggensee, G., Da¨umer, M., Eberle, J., Heiken, H., Kaiser, R., Knechten, H., Mu¨ller, H., Neifer, S., Schmidt, B., Walter, H., Gunsenheimer-Bartmeyer, B., Harrer, T., Hatzakis, Angelos E., Magiorkinis, Emmanouil N., Hatzitheodorou, Eleni, Haida, Catherine, Zavitsanou, Assimina, Magiorkinis, Gkikas, Lazanas, Marios C., Chini, Maria C., Magafas, N., Tsogas, Nickolaos, Paparizos, Vassilios A., Kourkounti, Sofia, Antoniadou, Anastasia C., Papadopoulos, Antonios I., Panagopoulos, Periklis, Poulakou, Garyphallia G., Sakka, V., Chryssos, Georgios, Drimis, Stylianos, Gargalianos, Panagiotis, Lelekis, Moyssis I., Chilomenos, G., Psichogiou, Mina A., Daikos, George L., Panos, George, Haratsis, G., Kordossis, Theodore, Kontos, Athanasios N., Koratzanis, Georgios, Theodoridou, Maria C., Mostrou, Glykeria J., Spoulou, Vana I., De Gascun, C., Byrne, C., Duffy, M., Bergin, C., Reidy, D., Farrell, G., Lambert, J., O'Connor, E., Rochford, A., Low, J., Coakely, P., O'Dea, S., Hall, W., Levi, I., Chemtob, D., Riva, C., Mussini, C., Caramma, I., Capetti, A., Colombo, M. C., Rossi, C., Prati, F., Tramuto, F., Vitale, F., Ciccozzi, M., Angarano, G., Rezza, G., Schmit, J. C., Hemmer, R., Arendt, V., Staub, T., Schneider, F., Roman, F., van Kessel, A., van Bentum, P. H. M., Brinkman, K., op de Coul, E. L., van der Ende, M. E., Hoepelman, I., van Kasteren, M., Juttmann, J., Kuipers, M., Langebeek, N., Richter, C., Santegoets, R., Schrijnders-Gudde, L., Schuurman, R., van de Ven, B. J. M., Ormaasen, V., Aavitsland, P., Stanczak, J. J., Stanczak, G. P., Firlag-Burkacka, E., Wiercinska-Drapalo, A., Jablonowska, E., Malolepsza, E., Leszczyszyn-Pynka, M., Szata, W., Palma, C., Borges, F., Paixa&tild, o, T., Duque, V., Araújo, F., Jevtovic, D., Salemovic, D., Habekova, M., Mokráš, Miloš, Truska, P., Lunar, M., Babic, Dunja Z., Tomazic, J., Vidmar, L., Vovko, T., Karner, P., Domingo, P., Galindo, M. J., Miralles, C., del Pozo, M. A., Ribera, E., Iribarren, J. A., Ruiz, L., de la Torre, J., Vidal, F., Garcia, F., Heidarian, A., Aperia-Peipke, K., Axelsson, M., Mild, M., Karlsson, A., Thalme, A., Nave´r, L., Bratt, G., Blaxhult, A., Gissle´n, M., Svennerholm, B., Bergbrant, I., Björkman, Per, Sa¨ll, C., Mellgren, A˚, Lindholm, A., Kuylenstierna, N., Montelius, R., Azimi, F., Johansson, B., Carlsson, M., Johansson, E., Ljungberg, B., Ekvall, H., Strand, A., Ma¨kitalo, S., o¨berg, S., Holmblad, P., Ho¨fer, M., Holmberg, H., Josefson, P., Ryding, U., Van Kessel, A., Kostrikis, Leontios G. [0000-0002-5340-7109], Paraskevis, Dimitrios [0000-0001-6167-7152], Virology, Erasmus MC other, Frentz, Dineke, Van de Vijver, David A.M.C., Abecasis, Ana B., Albert, Jan, Hamouda, Osamah, Jørgensen, Louise B., Ku¨cherer, Claudia, Struck, Daniel, Schmit, Jean-Claude, Vercauteren, Jurgen, A˚sjo¨, Birgitta, Balotta, Claudia, Beshkov, Danail, Camacho, Ricardo J., Clotet, Bonaventura, Coughlan, Suzie, Griskevicius, Algirda, Grossman, Zehava, Horban, Andrzej, Kolupajeva, Tatjana, Korn, Klau, Kostrikis, Leondios G., Liitsola, Kirsi, Linka, Marek, Nielsen, Clau, Otelea, Dan, Paraskevis, Dimitrio, Paredes, Roger, Poljak, Mario, Puchhammer-Sto¨ckl, Elisabeth, So¨nnerborg, Ander, Stanekova, Danica, Stanojevic, Maja, Van Wijngaerden, Eric, Wensing, Annemarie M.J., Boucher, Charles A.B., SPREAD programme investigators, including Vitale F and Tramuto F., Graduate School, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Service de médecine interne générale, UCL - (SLuc) Service d'hématologie, Clinicum, and Department of Medicine
- Subjects
Male ,virus strain ,Resistance ,HIV Infections ,Drug resistance ,THERAPY ,Nucleoside Reverse Transcriptase Inhibitor ,ANTIRETROVIRAL DRUG-RESISTANCE ,0302 clinical medicine ,Medical microbiology ,Genotype ,Medicine and Health Sciences ,Prevalence ,HIV Infection ,030212 general & internal medicine ,UNITED-KINGDOM ,Phylogeny ,0303 health sciences ,Communicable disease ,Transmission (medicine) ,adult ,virus mutation ,UPDATED RECOMMENDATIONS ,virus transmission ,3. Good health ,Europe ,Infectious Diseases ,female ,risk factor ,virus resistance ,Female ,NAIVE PATIENTS ,SOCIETY-USA PANEL ,Research Article ,Human ,Adult ,medicine.medical_specialty ,Anti-HIV Agents ,Virus ,Article ,03 medical and health sciences ,SDG 3 - Good Health and Well-being ,male ,MOLECULAR EPIDEMIOLOGY ,Drug Resistance, Viral ,medicine ,proteinase inhibitor ,Humans ,Transmission ,controlled study ,human ,molecular phylogeny ,030304 developmental biology ,nonhuman ,MUTATIONS ,business.industry ,Anti-HIV Agent ,nucleotide sequence ,nonnucleoside reverse transcriptase inhibitor ,Human immunodeficiency virus 1 infection ,Virology ,major clinical study ,unindexed sequence ,Parasitology ,3121 General medicine, internal medicine and other clinical medicine ,Mutation ,HIV-1 ,business - Abstract
Background: One out of ten newly diagnosed patients in Europe was infected with a virus carrying a drug resistant mutation. We analysed the patterns over time for transmitted drug resistance mutations (TDRM) using data from the European Spread program.Methods: Clinical, epidemiological and virological data from 4317 patients newly diagnosed with HIV-1 infection between 2002 and 2007 were analysed. Patients were enrolled using a pre-defined sampling strategy.Results: The overall prevalence of TDRM in this period was 8.9% (95% CI: 8.1-9.8). Interestingly, significant changes over time in TDRM caused by the different drug classes were found. Whereas nucleoside resistance mutations remained constant at 5%, a significant decline in protease inhibitors resistance mutations was observed, from 3.9% in 2002 to 1.6% in 2007 (p = 0.001). In contrast, resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs) doubled from 2.0% in 2002 to 4.1% in 2007 (p = 0.004) with 58% of viral strains carrying a K103N mutation. Phylogenetic analysis showed that these temporal changes could not be explained by large clusters of TDRM.Conclusion: During the years 2002 to 2007 transmitted resistance to NNRTI has doubled to 4% in Europe. The frequent use of NNRTI in first-line regimens and the clinical impact of NNRTI mutations warrants continued monitoring. © 2014 Frentz et al. licensee BioMed Central Ltd. 14 Cited By :16
- Published
- 2014
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