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Folding phenomenon refers to the formation of a specific conformation widely featured by the intramolecular interactions, which broadly exist in biomacromolecules, and are closely related to their structures and functions. A variety of oligomeric folded molecules have been designed and synthesized, namely "foldamer", exhibiting potentials in pharmaceutical and catalysis. Molecular folding is a promising strategy to transfer chirality from substituents to the whole skeleton, when chirality transfer, amplification, evolution, and other behaviors could be achieved. Investigating chirality using foldamer model deepens the understanding of the structure‐function correlation in biomacromolecules and expands the molecular toolbox towards chiroptical and asymmetrical chemistry. Substitutes with abundant hydrogen bonding sites conjugated to a rotatable aryl group afford a parallel β‐sheet‐like conformation, which enables the emergence and manipulation of axial chirality. This concept aims to give a brief introduction and summary of the hydrogen bonded foldamers with anchored axial chirality, by taking some recent cases as examples. Design principles, control over axial chirality and applications are also reviewed. [ABSTRACT FROM AUTHOR]

Hydrogels behave as potential candidates to investigate circularly polarized light (CP)‐matter interaction, which however suffer from small sensitivity towards circular polarization. Here we report a general protocol to build hydrogels from π‐conjugated amino acids with coassembled charge‐transfer (CT) complexes, covering a wide scope of donors and acceptors, which were incorporated into stable hydrogel matrices. CT complexes formed block coassemblies with gelators, induced the emergence of macroscopic chiral helices, where efficient chirality transfer occurs to realize tunable Cotton effects from visible light to NIR‐I region depending on the structures of CT pairs. The hybrid hydrogels showed tunable photothermal performances with excellent heating‐cooling cycling durability. Circularly polarized NIR light selectively triggered gel‐solution phase transition at different timescales. Left‐ and right‐CP illumination generates up to 2.5 folds difference in gel collapse time that allows for direct discrimination by naked eyes. [ABSTRACT FROM AUTHOR]

The halogen bond is the attractive interaction between the electrophilic region of a halogen atom and the nucleophilic region of another molecular entity, emerging as a favorable manner to manipulate supramolecular chirality in self‐assemblies. Engineering halogen bonded helical structures remains a challenge due to its sensitivity to solvent polarity and competitive forces like hydrogen bonds. Herein, we report a X⋅⋅⋅X (X=Cl, Br, I) type weak halogen bond that induces the formation and evolution of supramolecular helical structures both in solid and solution state. The π‐conjugated phenylalanine derivatives with F, Cl, Br and I substitution self‐assembled into 21 helical packing driven by hydrogen bond and halogen bond, respectively. The specific molecular geometries of π‐conjugated amino acids gave rise to multiple noncovalent forces to stabilize the X⋅⋅⋅X halogen bond with small bond energies ranging from −0.69 to −1.49 kcal mol−1. Halogen bond induced an opposite helicity compared to the fluorinated species, accompanied by the inversed circularly polarized luminescence. [ABSTRACT FROM AUTHOR]

Circularly polarized luminescence (CPL) active materials have received increasing attention due to their promising applications in fields such as photoelectric devices, spintronic devices and information storage systems. In developing CPL‐active materials, the key issue is to amplify the dissymmetry g‐factor (glum) and flexibly regulate the handedness, luminescence color and other properties. Relying on non‐covalent forces, multicomponent assembly provides an effective solution for control over CPL features. This Minireview summarizes recent progress in the regulation and amplification of CPL‐active materials in multicomponent coassembled systems, where the role of solvents, metal ions, quantum dots, achiral luminophores and nematic liquid crystals as well as a series of photophysical approaches including Förster resonance energy transfer (FRET), charge transfer (CT), arene‐perfluoroarene (AP) interactions and photon upconversion between different components are discussed. Furthermore, future challenges and opportunities of CPL‐active materials in multicomponent assembly systems are also reviewed. This Minireview aims to provide inspiration for the rational design and manufacture of CPL‐active materials based on multicomponent assembly. [ABSTRACT FROM AUTHOR]