81 results on '"YILMAZ, Sahin"'
Search Results
52. Effects of angiotensin converting enzyme inhibitor cilazapril and angiotensin II antagonist saralasin in ovarian hyper stimulation syndrome in the rabbit
- Author
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Olgun Kontaş, M Cankurtaran, Iptisam Ipek Muderris, and Yilmaz Sahin
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Ovulation ,endocrine system ,medicine.medical_specialty ,Menotropins ,medicine.drug_class ,Endocrinology, Diabetes and Metabolism ,media_common.quotation_subject ,Ovarian hyperstimulation syndrome ,Angiotensin-Converting Enzyme Inhibitors ,Cilazapril ,Chorionic Gonadotropin ,Ovarian Hyperstimulation Syndrome ,chemistry.chemical_compound ,Endocrinology ,Internal medicine ,medicine ,Animals ,Ascitic Fluid ,Progesterone ,media_common ,Estradiol ,biology ,business.industry ,Angiotensin II ,Body Weight ,Obstetrics and Gynecology ,Angiotensin-converting enzyme ,medicine.disease ,chemistry ,ACE inhibitor ,biology.protein ,Female ,Rabbits ,Gonadotropin ,Saralasin ,business ,medicine.drug - Abstract
We investigated the possible effects of the angiotensin converting enzyme (A CE) inhibitor cilazapril and angiotensin II antagonist saralasin on ovulation, ovarian steroidogenesis and ascites formation in the ovarian hyperstimulation syndrome (OHSS) in the rabbit model. OHSS was induced in rabbits by human menopausal gonadotropin (hMG) and intermittent human chorionic gonadotropin (hCG). In the cilazapril group (n = 10), animals also received cilazapril 2 mg/kg intraperitoneally daily for 7 days. In the saralasin group (n = 8), animals received saralasin intraperitoneally 1 h before or 1 h after hCG administration. Control animals (n = 8) received intraperitoneal saline solution. Serial blood samples were drawn on days 1, 5, 7 and 9 to measure serum estradiol and progesterone levels. On day 9, all rabbits underwent surgical exploration. Peritoneal and pleural fluid formation, ovarian weights and number of ovulations were determined. The volume of the ascitic and pleural fluids after hyperstimulation were not statistically different between the control, cilazapril and saralasin groups. The weight gains and ovarian weights of animals were similar between treatment and control groups. Saralasin significantly (p < 0.05) inhibited ovulation, but cilazapril did not. Cilazapril and saralasin did not affect progesterone production. Only cilazapril significantly decreased estradiol production (p < 0.05). In conclusion, the ACE inhibitor cilazapril and angiotensin II antagonist saralasin did not prevent ascites formation in OHSS. The ovarian renin-angiotensin system may not be the only factor acting in ascites formation in the OHSS.
- Published
- 1997
53. The prevalence of non-classic adrenal hyperplasia due to 11β-hydroxylase deficiency among hirsute women in a Turkish population
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Demet Ayata, Ahmet Tutuş, Yilmaz Sahin, and Fahrettin Kelestimur
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Adult ,Hirsutism ,endocrine system ,medicine.medical_specialty ,Turkish population ,Adolescent ,Turkey ,Endocrinology, Diabetes and Metabolism ,Cortodoxone ,Basal (phylogenetics) ,Endocrinology ,Sex hormone-binding globulin ,Internal medicine ,Prevalence ,medicine ,Humans ,Testosterone ,Androstenedione ,hirsutism ,Adrenal Hyperplasia, Congenital ,biology ,medicine.diagnostic_test ,business.industry ,ACTH stimulation test ,medicine.disease ,biology.protein ,Cosyntropin ,population characteristics ,Female ,business ,Hormone - Abstract
OBJECTIVE The present study was designed to determine the prevalence of 11 beta-hydroxylase deficiency in adult women with hirsutism in a Turkish population. DESIGN AND PATIENTS One hundred and twenty-four consecutive unselected hirsute patients were studied. An ACTH stimulation test was performed in the midfollicular phase of the cycle on the patients and 20 age-matched controls by administration of a single bolus of 0.25 mg ACTH (1-24) at 0900 h. MEASUREMENTS Serum 11-deoxycortisol levels were measured before, 30 and 60 minutes after ACTH injection. Basal free testosterone (fT), SHBG, cortisol and androstenedione (A) were also measured. The diagnosis of 11 beta-hydroxylase deficiency has been presumed when the serum 11-deoxycortisol response to ACTH stimulation exceeded three times the 95th percentile of controls. RESULTS Basal hormone levels including fT and A were significantly higher in the hirsute women than in the healthy women. SHBG was significantly lower in the hirsute patients. Basal and ACTH stimulated 11-deoxycortisol levels were found to be significantly increased in the patients compared with the controls. Eight patients (6.5%) had an 11-deoxycortisol response higher than three times the upper normal limit. CONCLUSIONS Using stringent diagnostic criteria, we have found that 6.5% of the hirsute women in a Turkish population could be presumed to have 11 beta-hydroxylase deficiency.
- Published
- 1996
54. Routine screening for Cushing's syndrome is not required in patients presenting with hirsutism
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Yilmaz Sahin, Zuleyha Karaca, Kursad Unluhizarci, Gökhan Açmaz, Banu Acmaz, Sulbiye Aribas, Fatih Tanriverdi, and Fahrettin Kelestimur
- Subjects
Adult ,medicine.medical_specialty ,Pediatrics ,Hirsutism ,Outpatient Clinics, Hospital ,Referral ,Adolescent ,Hydrocortisone ,Turkey ,Endocrinology, Diabetes and Metabolism ,Context (language use) ,Dexamethasone ,Tertiary Care Centers ,Young Adult ,Endocrinology ,Internal medicine ,medicine ,Prevalence ,Humans ,In patient ,Cushing Syndrome ,Glucocorticoids ,hirsutism ,Ovarian Function Tests ,Hyperplasia ,business.industry ,Ovary ,General Medicine ,medicine.disease ,Polycystic ovary ,stomatognathic diseases ,Follicular Phase ,Dexamethasone suppression test ,Etiology ,Female ,business ,Hyperandrogenism ,medicine.drug ,Polycystic Ovary Syndrome - Abstract
ContextPrevalence of Cushing's syndrome (CS) in patients presenting with hirsutism is not well known.ObjectiveScreening of CS in patients with hirsutism.SettingReferral hospital.Patients and other participantsThis study was carried out on 105 patients who were admitted to the Endocrinology Department with the complaint of hirsutism.InterventionAll the patients were evaluated with low-dose dexamethasone suppression test (LDDST) for CS.Main outcome measureResponse to LDDST in patients presenting with hirsutism.ResultsAll the patients had suppressed cortisol levels following low-dose dexamethasone administration excluding CS. The etiology of hirsutism was polycystic ovary syndrome in 79%, idiopathic hirsutism in 13%, idiopathic hyperandrogenemia in 6%, and nonclassical congenital hyperplasia in 2% of the patients.ConclusionRoutine screening for CS in patients with a referral diagnosis of hirsutism is not required. For the time being, diagnostic tests for CS in hirsute patients should be limited to patients who have accompanying clinical stigmata of hypercortisolism.
- Published
- 2012
55. Synergistic effects of carboxymethylcellulose and low molecular weight heparin in reducing adhesion formation in the rat uterine horn model
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Yilmaz Sahin and Abdullah Saglam
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medicine.medical_specialty ,medicine.drug_class ,medicine.medical_treatment ,Uterus ,Urology ,Low molecular weight heparin ,Adhesion (medicine) ,Tissue Adhesions ,Glycosaminoglycan ,Laparotomy ,medicine ,Animals ,Rats, Wistar ,Uterine Diseases ,business.industry ,Anticoagulant ,Obstetrics and Gynecology ,Uterine horns ,General Medicine ,Heparin ,Heparin, Low-Molecular-Weight ,medicine.disease ,Rats ,Surgery ,Disease Models, Animal ,medicine.anatomical_structure ,Carboxymethylcellulose Sodium ,Data Interpretation, Statistical ,Female ,business ,medicine.drug - Abstract
To investigate the effect of sodium carboxymethylcellulose (SCMC) and the combination of low molecular weight heparin (LMWH) with SCMC in the prevention of intraperitoneal adhesion.Thirty-eight rats underwent bilateral surgical injury to the uterine horn and the parietal peritoneum. In 13 rats, a solution of SCMC was instilled at laparotomy. In 11 rats, LMWH was delivered on to serosal and peritoneal defects, and SCMC was instilled. As a control group 14 rats were included in the study.Surgical Research Laboratory, Erciyes University.Female Wistar-Albino rats, weighing 200 to 250 g each.Adhesions between the uterine horn and the abdominal sidewall were scored for extent and severity two weeks after the initial surgery.Although the mean adhesion score both in the SCMC group (2.8, s.d. 1.15) and in the SCMC with LMWH group (1.6, s.d 1.18) was found to be significantly lower than in the control group (3.4, s.d. 0.89) (p0.05 and p0.001, respectively), more favorable adhesion prophylaxis was achieved in the SCMC with LMWH group in comparison with the SCMC treatment group without any hemorrhagic complications (p0.001).We conclude that SCMC with LMWH are highly effective in reducing postoperative adhesions in this animal model. SCMC with LMWH appears promising in adhesion prophylaxis.
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- 1994
56. The influence of obesity on ICSI outcomes in women with polycystic ovary syndrome
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Ercan Aygen, Cem Batukan, Gökalp Öner, Mahmut Tuncay Ozgun, Yilmaz Sahin, and Semih Uludag
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Infertility ,Adult ,medicine.medical_specialty ,Fresh embryo ,endocrine system diseases ,medicine.drug_class ,medicine.medical_treatment ,Intracytoplasmic sperm injection ,Miscarriage ,Body Mass Index ,Pregnancy ,Medicine ,Humans ,Obesity ,Sperm Injections, Intracytoplasmic ,Gynecology ,business.industry ,Long protocol ,nutritional and metabolic diseases ,Obstetrics and Gynecology ,medicine.disease ,Embryo Transfer ,Polycystic ovary ,female genital diseases and pregnancy complications ,Recombinant Proteins ,Abortion, Spontaneous ,Treatment Outcome ,Female ,Gonadotropin ,Follicle Stimulating Hormone ,business ,Infertility, Female ,Live Birth ,Polycystic Ovary Syndrome - Abstract
The objective of the study was to compare intracytoplasmic sperm injection (ICSI) outcome and gonadotropin doses between obese women with PCOS and non-obese patients with PCOS. This follow-up study represents ICSI outcomes in obese women with PCOS (BMI ≥ 30 kg/m(2)) compared with non-obese women with PCOS (BMI 30 kg/m(2)). Obese (n = 18) and non-obese (n = 26) women with PCOS underwent long protocol pituitary suppression, ovarian stimulation and ICSI with fresh embryo transfer. Obese patients with PCOS required higher doses of gonadotropin (2994 IU vs 1719 IU; p 0.001). Miscarriage rate was significantly higher in obese women compared with the non-obese women with PCOS (60% vs 6.7%, p = 0.002). Our results are valuable for counselling couples before initiation of assisted reproduction techniques (ART).
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- 2011
57. Acromegaly with Polycystic Ovaries, Hyperandrogenism, Hirsutism, Insulin Resistance and Acanthosis Nigricans: A Case Report
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Ali Ünal, Yilmaz Sahin, and Fahrettin Kelestimur
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Glucose tolerance test ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Endocrinology, Diabetes and Metabolism ,Insulin tolerance test ,Hyperandrogenism ,medicine.disease ,Polycystic ovary ,Endocrinology ,Insulin resistance ,Internal medicine ,Acromegaly ,medicine ,business ,Acanthosis nigricans ,hirsutism - Abstract
We describe a woman with acromegaly who had acanthosis nigricans and hirsutism. Serum growth hormone (GH) and testosterone levels were markedly elevated. Standard oral glucose tolerance test (OGTT) showed a diabetic curve and no suppressed GH levels. Fasting insulin levels were very high while plasma glucose levels were not hypoglycemic. Insulin tolerance test revealed blunted hypoglycemic response. Acanthosis nigricans was present in the right axilla and face. Ultrasonogram demonstrated bilateral polycystic changes in the ovaries. From the above findings this patient's condition is characteristic of a very rare syndrome consisting of acromegaly, polycystic ovaries (PCO), hyperandrogenism, hirsutism, insulin resistance and acanthosis nigricans.
- Published
- 1993
58. Validity and Reliability of a Turkish Version of the Modified Moral Sensitivity Questionnaire for Student Nurses
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Yilmaz Sahin, Sibel, primary, Iyigun, Emine, additional, and Acikel, Cengizhan, additional
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- 2015
- Full Text
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59. Metformin and polycystic ovary syndrome
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Ahmet Tutuş, Fahri Bayram, Yilmaz Sahin, Fahrettin Kelestimur, and Kursad Unluhizarci
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medicine.medical_specialty ,Endocrinology ,business.industry ,Endocrinology, Diabetes and Metabolism ,Internal medicine ,medicine ,business ,Polycystic ovary ,Metformin ,medicine.drug - Published
- 2000
60. [An evaluation of eight cases of intraosseous lipoma]
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Yilmaz, Sahin, Nevzat, Dabak, M Bekir, Selçuk, and Y Sancar, Bariş
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Adult ,Male ,Turkey ,Bone Neoplasms ,Humerus ,Middle Aged ,Severity of Illness Index ,Medical Records ,Calcaneus ,Treatment Outcome ,Humans ,Female ,Femur ,Lipoma ,Retrospective Studies - Abstract
We retrospectively evaluated patients with intraosseous lipoma.The study included eight patients (5 males, 3 females; mean age 39 years; range 23 to 60 years) who were treated between 1997 and 2005 for intraosseous lipoma. Localizations of the lipomas were the calcaneus in six patients, proximal humerus in one patient, and proximal femur in one patient. The presenting complaints were heel pain in patients with calcaneal involvement, and shoulder pain associated with proximal humeral involvement. In one patient, detection of intraosseous lipoma in the left proximal femur was incidental during examination for right hip pain. According to the Milgram classification, five of the intraosseous lipomas were stage 1, while two calcaneal lesions and one femoral lesion were stage 2. Treatment consisted of excisional biopsy, curettage, and allografting under regional or general anesthesia. The diagnosis was confirmed histopathologically in all cases. The mean follow-up period was 28 months (range 9 to 110 months).Complaints of heel pain and shoulder pain resolved within four and five months, respectively. No infection or skin necrosis occurred at the wound site. No neurovascular complications developed during or after surgery. Radiological consolidation of the implanted bone allografts were complete by a mean of three months (range 2 to 4 months). No pathological fractures or recurrences were encountered.Treatment of intraosseous lipomas with curettage and grafting is effective in relieving pain and preventing possible pathological fractures.
- Published
- 2008
61. The effects of metformin on metabolic and cardiovascular risk factors in nonobese women with polycystic ovary syndrome
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Yilmaz Sahin, Ayse Yilmazsoy, Fahrettin Kelestimur, Ali Yikilmaz, Ercan Aygen, and Kursad Unluhizarci
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medicine.medical_specialty ,Adolescent ,endocrine system diseases ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Young Adult ,Endocrinology ,Sex hormone-binding globulin ,Insulin resistance ,Risk Factors ,Internal medicine ,Sex Hormone-Binding Globulin ,medicine ,Humans ,Hypoglycemic Agents ,Testosterone ,Prospective Studies ,Menstrual Cycle ,Progesterone ,Glucose tolerance test ,medicine.diagnostic_test ,biology ,Free androgen index ,business.industry ,Insulin ,nutritional and metabolic diseases ,Glucose Tolerance Test ,Luteinizing Hormone ,medicine.disease ,Polycystic ovary ,Metformin ,female genital diseases and pregnancy complications ,Cardiovascular Diseases ,biology.protein ,Female ,Lipid profile ,business ,medicine.drug ,Polycystic Ovary Syndrome - Abstract
Summary Objective There are conflicting data regarding the effects of metformin in lean women with polycystic ovary syndrome (PCOS). Thus, our aim was to evaluate the effects of 6 months of metformin therapy on various metabolic and cardiovascular risk factors in lean women with PCOS. Design This was a prospective clinical study performed in a University hospital. Patients Twenty nonobese PCOS women and 20 age- and BMI-matched healthy women were included in the study. Metformin (2550 mg/day) was administered for 6 months in women with PCOS. The hormonal and metabolic parameters were evaluated before and after metformin treatment. Measurements The main outcome measures were serum androgens, FSH, LH, oestradiol, 17-hydroxyprogesterone, glucose, insulin, lipid profile, lipoprotein(a) [Lp(a)] and homocysteine levels. In addition 24-h ambulatory blood pressure monitoring (ABPM) and carotid intima-media thickness (IMT) were taken. Results After 6 months of metformin therapy, women with PCOS had decreased LH, total testosterone, free androgen index and slightly increased SHBG levels. Metformin treatment resulted in resumption of regular menses in 12 (60%) patients, and in 8 (40%) of them serum progesterone level was compatible with ovulation. Glucose and insulin responses to oral glucose tolerance test (OGTT) and homeostasis model assessment of insulin resistance (HOMA-IR) did not improve after the metformin therapy. There were no significant changes in terms of cardiovascular risk factors such as lipids and homocysteine, IMT and ABPM. Conclusion Metformin may have beneficial effects in lean PCOS women in terms of resumption of menses without any remarkable effect on metabolic and cardiovascular risk factors.
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- 2007
62. [Tendon repair with the strengthened modified Kessler, modified Kessler, and Savage suture techniques: a biomechanical comparison]
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Ahmet, Pişkin, Aydin, Yücetürk, Yilmaz, Tomak, Mete, Ozer, Birol, Gülman, Azat, Ataman, Mustafa, Kangal, Yilmaz, Sahin, Eren, Desteli, and Taner, Aliç
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Sheep ,Tendon Injuries ,Tensile Strength ,Suture Techniques ,Animals ,Biomechanical Phenomena - Abstract
The aim of the study was to develop a suture technique that would be simple and easy to perform, but also strong enough to resist the strength formed during early active exercise protocols.Thirty flexor digitorum profundus muscle tendons were obtained from lambs aged 12 to 16 months. The tendons were assigned to three in situ repair groups, including the modified Kessler technique, six-strand Savage technique, and a strengthened modified Kessler technique, all combined with an epitendinous suture. Each group was subjected to biomechanical tests and the maximum strength of the tendons to rupture and the power exerted to yield a 3-mm separation were recorded.The mean strengths of the tendons repaired with the modified Kessler technique for 3-mm separation and rupture were 29.9+/-2.9 N and 37.0+/-4.0 N, respectively. The corresponding forces were 39.1+/-6.7 N and 51.3+/-6.1 N with the six-strand Savage technique, and 59.9+/-8.3 N and 69.0+/-8.7 N with the strengthened modified Kessler technique, respectively. Forces to produce a 3-mm separation and rupture were significantly higher with the strengthened modified Kessler repair, whereas the lowest forces were seen with the modified Kessler technique (p0.001).Tendon repair with the strengthened modified Kessler technique provides the highest resistance to both 3-mm separation and rupture. These biomechanical properties may allow safe and active motion without any gap formation in the repair area.
- Published
- 2007
63. Cervical ripening before operative hysteroscopy in premenopausal women: a randomized, double-blind, placebo-controlled comparison of vaginal and oral misoprostol
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Cem Batukan, Yilmaz Sahin, Bülent Özçelik, Ercan Aygen, Mahmut Tuncay Ozgun, and Cagdas Turkyilmaz
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Adult ,medicine.medical_specialty ,Randomization ,Time Factors ,Uterine perforation ,Administration, Oral ,Hysteroscopy ,Placebo ,Drug Administration Schedule ,law.invention ,Randomized controlled trial ,Double-Blind Method ,Oral administration ,law ,Pregnancy ,Oxytocics ,Preoperative Care ,Medicine ,Humans ,Prospective Studies ,Misoprostol ,medicine.diagnostic_test ,business.industry ,Uterus ,Obstetrics and Gynecology ,medicine.disease ,Surgery ,Administration, Intravaginal ,medicine.anatomical_structure ,Treatment Outcome ,Reproductive Medicine ,Premenopause ,Vagina ,Uterine Perforation ,Female ,business ,Labor Stage, First ,medicine.drug ,Cervical Ripening - Abstract
Objective To compare the effectiveness of oral and vaginal misoprostol for preoperative cervical ripening in premenopausal women before hysteroscopic surgery. Design Placebo-controlled, double blind, randomized trial. Setting University hospital. Patient(s) Eighty-six premenopausal women eligible for operative hysteroscopy were recruited. Nine women were excluded from the study. Intervention(s) Patients were randomly assigned to receive 400 μg of misoprostol orally (n = 39) or vaginally (n = 38), 10–12 hours before operative hysteroscopy. Main Outcome Measure(s) Extent of initial cervical width, percentage of patients requiring cervical dilatation, duration of cervical dilatation and surgical procedure, complications during procedure, and associated side effects. Result(s) Mean cervical widths in the vaginal and oral misoprostol groups after treatment were 7.3 ± 1.6 mm and 6.0 ± 1.5 mm, respectively, which was a statistically significant difference. Time required for cervical dilatation (98.6 ± 88.7 s vs. 49.1 ± 34.9 s) and duration of surgery (14.5 ± 6 vs. 7.7 ± 4.0 min) was statistically significantly shorter in the vaginal misoprostol group. The percentage of women with an initial cervical width of 9 mm was statistically significantly higher in the vaginal misoprostol group (36.8% vs. 5.1%). Uterine perforation occurred in two patients in the oral misoprostol group and in none in the vaginal misoprostol group. Side effects were comparable between the two treatment groups. Conclusion(s) Vaginal administration of misoprostol is more effective than the oral route for preoperative cervical ripening in premenopausal women.
- Published
- 2007
64. Medical treatment regimens of hirsutism
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Yilmaz Sahin and Fahrettin Kelestimur
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Drug ,Hirsutism ,medicine.medical_specialty ,media_common.quotation_subject ,Spironolactone ,Terminal hair ,Ethinyl Estradiol ,Androgen Excess ,Flutamide ,chemistry.chemical_compound ,Internal medicine ,medicine ,Humans ,Hypoglycemic Agents ,Enzyme Inhibitors ,Cyproterone Acetate ,hirsutism ,Mineralocorticoid Receptor Antagonists ,media_common ,business.industry ,Finasteride ,Obstetrics and Gynecology ,Cyproterone acetate ,Androgen Antagonists ,medicine.disease ,Dermatology ,Metformin ,Drug Combinations ,Endocrinology ,Reproductive Medicine ,chemistry ,Female ,business ,Developmental Biology - Abstract
Hirsutism, which is a common clinical problem in women of reproductive age, is characterized by excessive growth of terminal hair in the androgen-sensitive skin regions. It is the result of either androgen excess or increased sensitivity of the hair follicles to normal levels of androgens. The management, which includes cosmetic measures and medical treatment, is far from satisfactory. Anti-androgen drugs play a key role in the treatment of hirsutism, but they have some side-effects which may result in cessation of the drug. On the other hand, anti-androgen treatment often needs to be continued for a long time. So, safe, inexpensive, and effective anti-androgen drugs are needed. Recently low-dose anti-androgen drugs have been shown to be effective in the maintenance of treatment. On the other hand, cyproterone acetate plus ethyniloestradiol and spironolactone, cyproterone acetate plus ethyniloestradiol and finasteride, and spironolactone and finasteride combinations have been used successfully in decreasing the hirsutism score. There are also some promising data regarding the effects of insulin sensitizers in the treatment of hirsutism, particularly in patients with polycystic ovarian syndrome. In the present review, the main features of anti-androgen drugs, new combined treatments, and insulin sensitizers in the treatment of hirsutism are discussed.
- Published
- 2004
65. The effects of metformin on insulin resistance, clomiphene-induced ovulation and pregnancy rates in women with polycystic ovary syndrome
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Ercan Aygen, Fahrettin Kelestimur, Yilmaz Sahin, and Ünal Yirmibeş
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Adult ,medicine.medical_specialty ,endocrine system diseases ,media_common.quotation_subject ,medicine.medical_treatment ,Clomiphene ,Endometrium ,Insulin resistance ,Ovulation Induction ,Clomifene ,Induced ovulation ,Pregnancy ,Internal medicine ,medicine ,Humans ,Hypoglycemic Agents ,Prospective Studies ,Ovulation ,Progesterone ,media_common ,Ultrasonography ,business.industry ,Obstetrics and Gynecology ,nutritional and metabolic diseases ,Glucose Tolerance Test ,medicine.disease ,Polycystic ovary ,Metformin ,Endocrinology ,Reproductive Medicine ,Ovulation induction ,Female ,Insulin Resistance ,business ,Infertility, Female ,medicine.drug ,Polycystic Ovary Syndrome - Abstract
Objective(s): To evaluate the effects of metformin on insulin resistance, ovarian androgen production, and clomiphene-induced ovulation and pregnancy rates in infertile women with polycystic ovary syndrome (PCOS). Study design: Twenty-one infertile women with PCOS were selected in this prospective randomized clinical study. Basal steroid and gonadotropin levels were measured, and oral glucose tolerance test (OGTT) was performed. The patients were divided randomly into group 1 (n = 11) and group 2 (n = 10). Group 1 patients were treated with 1700 mg per day of metformin for 3 months. The basal tests and OGTT were repeated after metformin therapy. Group 2 patients did not receive metformin. The patients in both groups received 100 mg of clomiphene citrate (CC) daily for 5 days until either a pregnancy occurred, or six CC cycles were reached. Metformin administration continued during CC therapy until the day of hCG in group 1. Serum progesterone (P) level greater than or equal to5 ng/ml was considered as confirmatory of ovulation. Ovulation and pregnancy rates after six cycles were determined. Results: Serum androgens and insulin response to OGTT decreased significantly after metformin therapy. Midluteal serum P level was significantly higher in cycles treated with metformin plus CC (P < 0.05). The ovulation (38 of 51 cycles, 74.4% versus 34 of 55 cycles, 61.8%) and pregnancy rates (5 of 11 women, 45.5% versus 3 of 10 women, 30%) were higher, but not significantly, in the metformin plus CC group than in the CC alone group. All the patients who conceived had insulin resistance in group 1 whereas non-insulin resistance in group 2. Conclusion(s): Metformin improves insulin resistance and reduces androgen levels. Metformin did not increase significantly the ovulation and pregnancy rates. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
- Published
- 2004
66. Comparison of Diane 35 and Diane 35 plus finasteride in the treatment of hirsutism
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Yilmaz Sahin, Sermin Dilber, and Fahrettin Kelestimur
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Adult ,medicine.medical_specialty ,Hirsutism ,Population ,Urology ,Ethinyl Estradiol ,Body Mass Index ,chemistry.chemical_compound ,5-alpha Reductase Inhibitors ,Ethinylestradiol ,Sex Hormone-Binding Globulin ,Medicine ,Humans ,Testosterone ,Prospective Studies ,Enzyme Inhibitors ,education ,Cyproterone Acetate ,hirsutism ,Gynecology ,education.field_of_study ,business.industry ,Dehydroepiandrosterone Sulfate ,Finasteride ,Androstenedione ,Obstetrics and Gynecology ,Cyproterone acetate ,Androgen Antagonists ,medicine.disease ,Drug Combinations ,Reproductive Medicine ,chemistry ,Blood chemistry ,Cyproterone ,Drug Therapy, Combination ,Female ,business ,hormones, hormone substitutes, and hormone antagonists ,medicine.drug - Abstract
Objective: To compare the clinical efficacy and safety of the combination of Diane 35 (2 mg of cyproterone acetate, and 35 μg of ethinyl estradiol) plus finasteride (5 mg), and Diane 35 alone in the treatment of hirsutism. Design: Prospective randomized clinical study. Setting: Outpatients in Erciyes University Medical School. Patient(s): Forty women with hirsutism were selected. Intervention(s): For 1 year, group 1 patients (n = 20) were treated with Diane 35 alone (2 mg of cyproterone acetate and 35 μg of ethinyl estradiol) daily on days 5 to 25 of the menstrual cycle and group 2 patients (n = 20) with Diane 35 plus finasteride (5 mg daily). Main Outcome Measure(s): Hirsutism was graded at 6-month intervals using the Ferriman-Gallwey method. The basal hormone levels of total and free testosterone (T), androstenedione, DHEAS, and sex-hormone-binding globulin (SHBG) were measured by radioimmunoassay before the study. Total T, free T, SHBG, and DHEAS were also measured at 6-month intervals for 1 year. Multiscreen blood chemistry and side effects were evaluated during the treatment. Result(s): Thirty-four patients completed the 12-month study period. A significant decrease in the hirsutism score as compared to baseline was observed after 12 months with both Diane 35 treatment (mean ± SD, 15.62 ± 4.89 vs. 9.75 ± 3.97) and Diane 35 plus finasteride treatment (16.27 ± 6.90 vs. 8.38 ± 4.44). The percentage decreases in the hirsutism score (mean percent ± SD) were 30.26 ± 14.56 vs. 34.70 ± 11.60 at 6 months, 38.09 ± 11.46 vs. 48.14 ± 14.27 at 12 months in the Diane 35 and the Diane 35 plus finasteride groups, respectively. The percentage reduction in the hirsutism score in the Diane 35 plus finasteride group at 12 months was greater than in the Diane 35 group ( P Conclusion(s): The percentage decrease in the hirsutism score at 12 months was higher in the Diane 35 plus finasteride group than in the Diane 35 group. We believe that Diane 35 plus finasteride is an effective and safe combination for the treatment of hirsutism.
- Published
- 2001
67. Alternate pathway 17,20-lyase enzyme activity in the adrenals is enhanced in patients with polycystic ovary syndrome
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Fahrettin Kelestimur and Yilmaz Sahin
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Adult ,endocrine system ,medicine.medical_specialty ,endocrine system diseases ,Cortodoxone ,Adrenocorticotropic hormone ,Basal (phylogenetics) ,Adrenocorticotropic Hormone ,Internal medicine ,Adrenal Glands ,medicine ,Humans ,Androstenedione ,Prospective Studies ,Prospective cohort study ,Hydrocortisone ,biology ,17-alpha-Hydroxyprogesterone ,Obstetrics and Gynecology ,Steroid 17-alpha-Hydroxylase ,Polycystic ovary ,female genital diseases and pregnancy complications ,Enzyme assay ,Kinetics ,Endocrinology ,Reproductive Medicine ,biology.protein ,Female ,Glucocorticoid ,medicine.drug ,Polycystic Ovary Syndrome - Abstract
Objective: To assess the activity of the enzyme cytochrome P450c17α in patients with polycystic ovary syndrome (PCOS). Design: Prospective clinical study. Setting: Outpatients at Erciyes University Medical School, Kayseri, Turkey. Patient(s): Twenty-eight women with PCOS aged 25.44 ± 4.37 years (mean ± SD) and 18 normal women aged 26.94 ± 3.17 years. Main Outcome Measure(s): Serum levels of 11-deoxycortisol, androstenedione (A), and 17α-hydroxy progesterone were measured before and 30 and 60 minutes after ACTH (0.25 mg IV) injection. Result(s): There was a statistically significant correlation between basal levels of 11-deoxycortisol (4.05 ± 1.16 ng/mL) and A (3.36 ± 0.97 ng/mL) (r = 0.539). The peak level of 11-deoxycortisol (7.82 ± 2.36 ng/mL) was also significantly correlated with the peak level of A (6.66 ± 1.32 ng/mL) (r = 0.570) in women with PCOS. There was no statistically significant correlation between basal A (2.33 ± 0.50 ng/mL) and basal 11-deoxycortisol (2.71 ± 0.59 ng/mL) or between peak A (3.38 ± 0.50 ng/mL) and peak 11-deoxycortisol (3.68 ± 0.48 ng/mL) levels in control subjects. Conclusion(s): We believe that PCOS is characterized by enhanced activity of 17,20-lyase enzyme in an alternate pathway between 11-deoxycortisol and A in the adrenal glands.
- Published
- 1999
68. Comparison of Diane 35 and Diane 35 plus spironolactone in the treatment of hirsutism
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Fahrettin Kelestimur and Yilmaz Sahin
- Subjects
Adult ,medicine.medical_specialty ,Hirsutism ,Adolescent ,medicine.drug_class ,Urology ,Spironolactone ,Antiandrogen ,Ethinyl Estradiol ,chemistry.chemical_compound ,Sex hormone-binding globulin ,Estradiol Congeners ,Ethinylestradiol ,medicine ,Humans ,Prospective Studies ,Prospective cohort study ,Cyproterone Acetate ,hirsutism ,Mineralocorticoid Receptor Antagonists ,Gynecology ,biology ,business.industry ,Obstetrics and Gynecology ,Cyproterone acetate ,medicine.disease ,Hormones ,Drug Combinations ,Treatment Outcome ,Reproductive Medicine ,chemistry ,biology.protein ,Cyproterone ,Female ,business ,hormones, hormone substitutes, and hormone antagonists ,medicine.drug - Abstract
Objective: To compare the clinical efficacy and safety of Diane 35 (cyproterone acetate [2] mg and ethinyl estradiol [35μg]) plus spironolactone [100mg]combination and Diane 35 alone in the treatment of hirsutism. Design: Prospective clinical study. Setting: Outpatients in Erciyes University Medical School. Patient(s): Fifty women with hirsutism. Intervention(s): Group I patients ( n = 22) were treated with Diane 35 alone and group II patients ( n = 28) with Diane 35 plus spironolactone [100mg]. Main Outcome Measure(s): The basal hormone levels total and free T, androstenedione, DHEAS, sex hormone-binding globulin (SHBG), and prolactin (PRL) were measured by RIA before the study. Free T, SHBG, and DHEAS were also measured at 6-month intervals for 12 months. Hirsutism was graded at 6-month intervals. Result(s): The basal hormone levels were similar between the groups. Hirsutism score significantly decreased at the end of the therapy in both groups. The reduction in hirsutism score in group 11 at 12 months was greater than in group I. But the scores before the treatment, at 6 and 12 months were similar between the groups. Conclusion(s): Although the actual hirsutism score and free T concentration are not significantly different between the two groups at 12 months, percentage change in the hirsutism score at 12 months was higher in the Diane 35 plus spironolactone group. Therefore, the addition of spironolactone to Diane 35 may have a synergistic effect on hirsutism score.
- Published
- 1998
69. The frequency of late-onset 21-hydroxylase and 11 beta-hydroxylase deficiency in women with polycystic ovary syndrome
- Author
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Fahrettin Kelestimur and Yilmaz Sahin
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Adult ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Basal (phylogenetics) ,chemistry.chemical_compound ,Endocrinology ,Sex hormone-binding globulin ,Dehydroepiandrosterone sulfate ,Adrenocorticotropic Hormone ,Internal medicine ,medicine ,Humans ,Androstenedione ,Steroid 11-beta-hydroxylase ,Testosterone ,biology ,Adrenal Hyperplasia, Congenital ,business.industry ,21-Hydroxylase ,Age Factors ,Obstetrics and Gynecology ,General Medicine ,Polycystic ovary ,chemistry ,biology.protein ,Female ,business ,Polycystic Ovary Syndrome - Abstract
OBJECTIVE: To determine the frequency of late-onset adrenal hyperplasia (LOCAH) due to 21-hydroxylase (21-OH) and 11 beta-hydroxylase (11 beta-OH) deficiency in women with clinical and biochemical features of polycystic ovary syndrome (PCOS). DESIGN: Eighty-three consecutively selected women with PCOS and eighteen normal women were included in the study. METHODS: Ultrasound, clinical and hormonal parameters were used to define PCOS. Basal FSH, LH, testosterone, free testosterone, androstenedione, dehydroepiandrosterone sulfate (DHEA-S), sex hormone-binding globulin (SHBG) and cortisol levels were measured. Serum 17-hydroxyprogesterone (17-OHP) and 11-deoxycortisol (11-DOC) levels were also measured before, 30 and 60 min after a single bolus injection of 0.25 mg ACTH (1-24) at 0900 h during the mid-follicular phase of the cycle. ACTH-stimulated 17-OHP levels > 30 nmol/l were considered as the criteria of 21-OH deficiency. The diagnosis 11 beta-OH deficiency was made if the adrenal 11-DOC response to ACTH stimulation exceeded threefold the 95th percentile of controls. RESULTS: Basal serum testosterone, free testosterone, androstenedione, DHEA-S, cortisol and 11-DOC levels were significantly higher in PCOS than in control subjects. ACTH-stimulated 17-OHP (P < 0.05) and 11-DOC (P < 0.0005) levels were found to be significantly higher in patients with PCOS than in controls. Seven (8.4%) patients had an 11-DOC response to ACTH higher than threefold the 95th percentile of controls, while no patients showed evidence of 21-OH deficiency. CONCLUSIONS: We have found that 8.4% of the women with clinical and biochemical features of PCOS could be presumed to have 11 beta-OH deficiency. No patients among the women with PCOS showed evidence of 21-OH deficiency. 11 beta-OH deficiency is unexpectedly more common than 21-OH deficiency in women with PCOS.
- Published
- 1997
70. A comparison between two doses of flutamide (250 mg/d and 500 mg/d) in the treatment of hirsutism
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Iptisam Ipek Muderris, Fahrettin Kelestimur, Yilmaz Sahin, and Fahri Bayram
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Adult ,medicine.medical_specialty ,Hirsutism ,Time Factors ,medicine.drug_class ,medicine.medical_treatment ,Urology ,Flutamide ,chemistry.chemical_compound ,Internal medicine ,medicine ,Humans ,Prospective Studies ,hirsutism ,Chemotherapy ,Dose-Response Relationship, Drug ,business.industry ,Obstetrics and Gynecology ,Androgen Antagonists ,Androgen ,medicine.disease ,Endocrinology ,Treatment Outcome ,Reproductive Medicine ,Blood chemistry ,chemistry ,Flutamide 250 MG ,Female ,business ,Body mass index ,Hormone - Abstract
To compare the effects of flutamide at 250 mg/d and 500 mg/d in the treatment of hirsutism.Randomized, prospective clinical study.Sixty-five patients with moderate to severe hirsutism.Group I (n = 35) patients were treated with flutamide, 250 mg/d, and group II (n = 30) patients were treated with flutamide, 500 mg/d, for 12 months. Baseline hormone levels, body mass index, and hirsutism scores were similar between the groups. Hirsutism score, hormone levels, and multiscreen blood chemistry were measured at 3-month intervals for 12 months.The modified Ferriman-Gallwey scores for hirsutism decreased significantly at months 6 and 12 from a mean +/- SEM of 17.8 +/- 0.9 to 6.0 +/- 0.6 (P0.001) and 17.8 +/- 0.9 to 4.8 +/- 0.7 (P0.001) in group I and from 17.0 +/- 0.9 to 6.6 +/- 0.7 and 17.0 +/- 0.9 to 5.2 +/- 0.7 (P0.001) in group II, respectively. The reductions in hirsutism scores (mean +/- SEM) were similar in group I at 6 months (64.6% +/- 2.5%) and at 12 months (71.2% +/- 2.2%) and in group II at 6 months (62.1% +/- 3.0%) and at 12 months (70.3% +/- 3.0%). The percent reductions in hirsutiam scores at 6 and at 12 months were similar within group I (64.6% +/- 2.5% and 71.2% +/- 2.2%) and group II (62.1% +/- 3.0% and 70.3% +/- 3.0%), respectively. The decreases in hirsutism scores in the first 6 months were more significant than in the last 6 months of treatment in both groups. There were no significant differences in any of the hormone levels during therapy in either group. One patient in group II was excluded from the study because of liver dysfunction.This study shows that two different doses of flutamide (250 mg/d and 500 mg/d) are similarly effective in reducing hair growth. Flutamide at a dose of either 250 mg/d or 500 mg/d has no further effect after 6 months. We conclude that if flutamide is administered at a dose of 250 mg/d it may represent an effective and well tolerated treatment with reduced cost for the patient.
- Published
- 1997
71. Lack of relationship between 17-hydroxyprogesterone response to buserelin testing and hyperinsulinemia in polycystic ovary syndrome
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Fahrettin Kelestimur, Demet Ayata, and Yilmaz Sahin
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Adult ,medicine.medical_specialty ,endocrine system ,Time Factors ,Adolescent ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Biology ,Buserelin ,Gonadotropin-Releasing Hormone ,Endocrinology ,Hyperinsulinism ,Internal medicine ,medicine ,Hyperinsulinemia ,Humans ,Insulin ,Testosterone ,Glucose tolerance test ,C-Peptide ,medicine.diagnostic_test ,17-alpha-Hydroxyprogesterone ,Steroid 17-alpha-Hydroxylase ,General Medicine ,Glucose Tolerance Test ,Luteinizing Hormone ,medicine.disease ,Polycystic ovary ,Prolactin ,Glucose ,Hydroxyprogesterone ,Female ,Follicle Stimulating Hormone ,hormones, hormone substitutes, and hormone antagonists ,Polycystic Ovary Syndrome ,medicine.drug ,Hormone - Abstract
Objective: To determine whether hyperinsulinism affects cytochrome P450c 17α activity by investigating the correlation between 17–hydroxyprogesterone (17–OHP) hyper-responsiveness to the gonadotropin-releasing hormone (GnRH) agonist, buserelin, and the insulin response to oral glucose in polycystic ovary syndrome (PCOS). Design: Ultrasound, clinical and hormonal parameters were used to define PCOS in this prospective clinical study. We investigated the correlation between the 17–OHP response to buserelin testing and the insulin response to oral glucose in PCOS. Methods: Twenty-eight women with PCOS and eighteen normal women were included in the study. 17–OHP response to buserelin, and insulin and C–peptide responses to oral glucose were measured. Results: Twenty–live women with PCOS had an increased 17–OHP response. The PCOS patients showed significantly higher mean post–glucose load insulin and C–peptide levels than controls (PP >0·05). Conclusions: Lack of a relationship between the 17–OHP response to the GnRH agonist buserelin and hyperinsulinism suggests that hyperinsulinism may not play a role in the dysregulation of the cytochrome P450c17α enzyme seen in PCOS. European Journal of Endocrinology 136 410–415
- Published
- 1997
72. The efficacy of 250 mg/day flutamide in the treatment of patients with hirsutism
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Fahrettin Kelestimur, Ahmet Tutuş, Demet Ayata, Iptisam Ipek Muderris, Fahri Bayram, and Yilmaz Sahin
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Adult ,Hirsutism ,medicine.medical_specialty ,Adolescent ,medicine.drug_class ,medicine.medical_treatment ,Urology ,Antiandrogen ,Flutamide ,chemistry.chemical_compound ,Internal medicine ,Humans ,Medicine ,Testosterone ,Prospective Studies ,Androstenedione ,Progesterone ,hirsutism ,Chemotherapy ,Dose-Response Relationship, Drug ,business.industry ,Obstetrics and Gynecology ,Androgen Antagonists ,Estrogens ,Luteinizing Hormone ,medicine.disease ,Clinical trial ,Endocrinology ,Reproductive Medicine ,chemistry ,Hirsutism score ,Female ,Follicle Stimulating Hormone ,business ,Hormone - Abstract
Objective To investigate the effects of low dose flutamide (250mg/d) on hirsutism score and some hormone levels in women with hirsutism. Design Nonrandomized, prospective clinical trial. Patients Forty-one patients with moderate-severe hirsutism were included in the study. Intervention Hirsute patients received 250mg/d flutamide for a period of 6 months. Main Outcome Measures Hirsutism score, FSH, LH, E 2 , total T, free T, androstenedione, DHEAS, PRL, 17-hydroxyprogesterone, and sex hormone-binding globulin levels were detected in all the patients before treatment and every 3 months during treatment. Results Treatment with the antiandrogen flutamide resulted in a particularly rapid and marked decrease in the hirsutism score, which decreased from 17.48±5.35 to 5.07±2.89 after 6 months. No significant changes in the levels of hormone and no serious side effects were observed in the study. Conclusion The low-dose flutamide, 250mg/d, is a cost-effective drug in the treatment of hirsutism. Low-dose flutamide may be used in place of high-dose flutamide, 500 to 750mg/d.
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- 1996
73. M013 EFFECT OF BODY MASS INDEX ON THE RISK OF MISCARRIAGE AFTER ICSI
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Mehmet Serdar Kutuk, Yilmaz Sahin, Semih Uludag, Ahmet Öztürk, Mahmut Tuncay Ozgun, and Ercan Aygen
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medicine.medical_specialty ,Obstetrics ,business.industry ,medicine ,Obstetrics and Gynecology ,General Medicine ,medicine.disease ,business ,Body mass index ,Miscarriage - Published
- 2012
74. 17-HYDROXYPROGESTERONE RESPONSE TO BUSERELIN TESTING IN THE POLYCYSTIC-OVARY-SYNDROME
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Yilmaz Sahin and Fahrettin Kelestimur
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Adult ,Agonist ,medicine.medical_specialty ,endocrine system ,Adolescent ,endocrine system diseases ,medicine.drug_class ,Endocrinology, Diabetes and Metabolism ,Adrenocorticotropic hormone ,Buserelin ,Dexamethasone ,Basal (phylogenetics) ,Endocrinology ,Adrenocorticotropic Hormone ,Internal medicine ,Hydroxyprogesterones ,medicine ,Humans ,Testosterone ,business.industry ,17-alpha-Hydroxyprogesterone ,Ovary ,Radioimmunoassay ,Luteinizing Hormone ,Polycystic ovary ,female genital diseases and pregnancy complications ,Hydroxyprogesterone ,Female ,Follicle Stimulating Hormone ,business ,Polycystic Ovary Syndrome ,medicine.drug - Abstract
Summary OBJECTIVE We determined the 17-hydroxyprogesterone (17-OH P) response to buserelin, a GnRH agonist, and its relation to ovarian volume in the patients with polycystic ovary syndrome (PCOS). DESIGN We compared 17-OH P response to buserelin in a large group of patients with that In a control group of healthy women. We also investigated whether there is any relation between LH-induced 17-OH P production in response to buserelin and ovarian volume. PATIENTS Ten normal women and 31 women with PCOS were included in the study. MEASUREMENT Pelvic ultrasound examination by abdominal or vaginal transducer was performed. Serum basal levels of LH, FSH, free testosterone and 17-OH P were measured by radioimmunoassay. 17-OH P responses to both ACTH and buserelin were detected. Cortisol levels were measured before and after dexamethasone suppression. RESULTS The subcutaneous administration of 1 mg buserelin produced an increase in serum 17-OH P, which peaked within 24 hours in all groups. The mean ±SEM level of 17-OH P, 24 hours after buserelin stimulation in the women with PCOS (15.94 ±1.31 nmol/l) was significantly higher (P
- Published
- 1993
75. Relationship of ovarian stromal volume and serum 17-hydroxyprogesterone concentrations in patients with PCOS
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Fahrettin Kelestimur and Yilmaz Sahin
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medicine.medical_specialty ,Stromal cell ,business.industry ,Rehabilitation ,Obstetrics and Gynecology ,Text mining ,Endocrinology ,Reproductive Medicine ,Volume (thermodynamics) ,Internal medicine ,medicine ,Hydroxyprogesterone ,In patient ,business - Published
- 1999
76. Investigation of the relationship between social appearance anxiety and perceived social support in patients with burns.
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Ayhan, Hatice, Savsar, Adile, Yilmaz Sahin, Sibel, and Iyigun, Emine
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SOCIAL anxiety , *SOCIAL support , *PEARSON correlation (Statistics) , *BURN patients , *MENTAL depression , *MULTIPLE regression analysis , *BURNS & scalds complications , *BURNS & scalds , *QUESTIONNAIRES , *AMPUTATION , *ANXIETY , *PSYCHOSOCIAL factors - Abstract
Introduction: Since burns affect body image, they cause appearance anxiety. Interventions designed to reduce appearance anxiety that can cause psychological problems such as depression are important. This study aimed to determine the social appearance anxiety of individuals following burns and the factors affecting it and to examine the relationship between social appearance anxiety and perceived social support.Methods: This descriptive study was conducted between November 2018 and November 2019 with 106 adult patients with burns. Data were collected using a Personal Information Form, the Social Appearance Anxiety Scale, and the Multidimensional Scale of Perceived Social Support. Shapiro-Wilk test, Independent Two Samples T-Test, One Way Analysis of Variance, Duncan's test, Pearson's correlation analysis, multiple linear regression analysis, the Q-Q plot, and the Durbin-Watson statistics were used in data analysis.Results: The social appearance anxiety scores were moderate (39.38 ± 17.71). Being single; having a high level of education; burns on the face, head, or neck; burn-related amputation; and passing the one-week after injury period were found to significantly increase social appearance anxiety (p < 0.05). Although the perceived social support scores of the individuals with burns were high (68.34 ± 18.08), they were found to have no correlation with social appearance anxiety (p > 0.05).Conclusions: The results of this study show that social support does not affect social appearance anxiety. In this respect, we recommend that interventions such as reconstruction and professional psychological support initiatives be prioritized for individuals with burn trauma who are evaluated to have high social appearance anxiety by the appearance anxiety scales. [ABSTRACT FROM AUTHOR]- Published
- 2022
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77. The Effect of Music Therapy After Bariatric Surgery on Postoperative Nausea Vomiting and Patient Satisfaction (BSMusicPONV)
- Author
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Sibel Yilmaz Sahin, Assistant Professor
- Published
- 2023
78. To estimate the major allergen in multi-sensitized children with rhinitis: is nasal provocation really needed?
- Author
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Yuce, E. G., Ogulur, I., Karakoc-Aydiner, E., Baris, S., Ayca Kiykim, Yilmaz, Sahin A., Oysu, C., Ozen, A., and Barlan, I.
79. Association of drugs and presence or development of obsessive-compulsive symptoms in schizophrenia patients: a naturalistic longitudinal observation during hospitalization.
- Author
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Uzun, Ugras Erman, Yilmaz Sahin, Feride Betul, Cirakoglu, Tuba, Dundar, Emrullah, Sancak, Baris, and Erkiran, Murat
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OBSESSIVE-compulsive disorder , *SCHIZOPHRENIA , *PSYCHOSES , *SYMPTOMS , *HOSPITAL care - Abstract
Objective: To investigate existing obsessive-compulsive symptoms in hospitalized schizophrenia patients and to observe the association of these symptoms and medical treatment from hospitalization to discharge. Methods: This study included 45 patients with schizophrenia hospitalized at the men's psychotic disorders clinic at Bakirkoy Mazhar Osman Mental Health and Neurological Diseases Education and Research Hospital in April-May 2014. Patients were reevaluated at hospitalization with SCID-I (The Structured Clinical Interview for DSM-IV Axis I Disorders) by a psychiatrist to confirm the diagnosis and to define any additional diagnosis. Particular socio-demographic and clinical features are received. Obsessive-compulsive symptoms severity was measured with the Yale-Brown Obsessive Compulsive Scale (Y-BOCS), psychotic symptoms severity with the Positive and Negative Syndrome Scale (PANSS). Results: A total of 12 out of 45 patients had obsessive compulsive symptoms. We had two group of patients, Group I without antipsychotic treatment for at least 3 months (19 patients) and group II with antipsychotic treatment (26 patients). Group I had higher PANSS positive, PANSS negative and PANSS total scores and group II had higher Y-BOCS scores at the time of hospitalization. Conclusion: Our results show that the patients with obsessive compulsive symptoms had higher PANSS scores. [ABSTRACT FROM AUTHOR]
- Published
- 2015
80. Effect of Semi-recumbent Position on Treatment of Shoulder Pain Seen After Laparoscopic Cholecystectomy (SRPSP)
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Sibel Yilmaz Sahin, Assistant professor
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- 2022
81. The level of two trace elements in carious, non-carious, primary, and permanent teeth
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Sahin Yilmaz, Pakize Neslihan Taşlı, Gülşah Balan, Serap Akyüz, Fikrettin Sahin, Ruya Kuru, Aysen Yarat, Kuru, Ruya, Balan, Gulsah, Yilmaz, Sahin, Tasli, Pakize Neslihan, Akyuz, Serap, Yarat, Aysen, and Sahin, Fikrettin
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inorganic chemicals ,Boron,Fluoride,Teeth,Trace elements,Dental health ,Dentistry ,chemistry.chemical_element ,trace elements ,ZINC ,chemistry.chemical_compound ,Diş Hekimliği ,stomatognathic system ,Carious teeth ,Health Care Sciences and Services ,dental health ,Sağlık Bilimleri ve Hizmetleri ,Boron ,Permanent teeth ,teeth ,Permanent tooth ,fluoride ,DENTIN ,business.industry ,Chemistry ,Dental health ,Articles ,Biological Sciences ,lcsh:RK1-715 ,stomatognathic diseases ,lcsh:Dentistry ,Dental ,SEX ,Negative correlation ,business ,boron ,Fluoride - Abstract
Purpose: The boron and fluoride mainly accumulate in the bones and teeth of the human body. The purpose of this study is to determine boron or fluoride levels in the whole tooth, to evaluate the correlation between their levels and to compare these levels in primary/permanent, carious, and non-carious groups. Materials and Methods: The boron and fluoride levels of thirty-six teeth, separated such as primary carious (n=9) and non-carious (n=9), permanent carious (n=9) and non-carious (n=9), were determined by ICP-MS and ion-selective electrode, respectively. Results: While boron levels were between 0.001 and 5.88 ppm, the fluoride levels were between 21.24 and 449.22 ppm. The boron level of non-carious teeth was higher than those of carious teeth in primary and permanent tooth groups. However, this difference was not statistically significant (p>0.05). The fluoride level of non-carious teeth was higher than those of carious teeth in primary (p=0.062) and permanent teeth groups (p=0.046). Negative correlation, found between boron and fluoride in all groups, was significant only in non-carious teeth group (r=-0.488, p=0.040). Conclusion: The results of our study proved the importance of fluoride as a protective factor for dental caries once more. The boron levels in non-carious teeth were also higher than carious teeth. However, it was not significant. Moreover, there was negative correlation between teeth boron and fluoride levels. Therefore, it is necessary to conduct more detailed studies on the tooth boron level and its relation with caries formation and with fluoride levels.
- Published
- 2020
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