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ObjectiveTo explore the effective prevention of wild mushroom poisoning， the years of life lost （YLLs） from wild mushroom poisoning in Yunnan Province from 2017 to 2021 was calculated .MethodsThe death data of wild mushroom poisoning in Yunnan Province were collated according to gender， age and year. The YLLs was calculated based on the World Health Organization excel calculation template， and the YLLs was compared among different age， gender and year groups. The indirect economic loss was estimated using human capital approach.ResultsThe YLLs due to wild mushroom poisoning was 2 760 person-years （5.70 person years per 100 000 population）. People aged from 30 to 59 years old were a risk group for wild mushroom poisoning with YLLs of 1 602 person-years. Children aged

The 26S proteasome is the major proteolytic machine for breaking down cytosolic and nuclear proteins in eukaryotes. Due to the lack of a suitable assay, it is difficult to measure routinely and quantitatively the breakdown of proteins by the 26S proteasome in vitro. In the present study, we developed an assay to monitor proteasome-mediated protein degradation. Using this assay, we discovered that epidithiodiketopiperazine (ETPs) blocked the degradation of our model substrate in vitro. Further characterization revealed that ETPs inhibited proteasome function by targeting the essential proteasomal deubiquitinase Rpn11 (POH1/PSMD14). ETPs also inhibited other JAMM (JAB1/MPN/Mov34 metalloenzyme) proteases such as Csn5 and AMSH. An improved ETP with fewer non-specific effects, SOP11, stabilized a subset of proteasome substrates in cells, induced the unfolded protein response, and led to cell death. SOP11 represents a class of Rpn11 inhibitor and provides an alternative route to develop proteasome inhibitors.

In this article, we are interested in the following Kirchhoff-type problem (0.1)−a+b∫RN∣∇u∣2dxΔu+V(∣x∣)u=∣u∣2uinRN,u∈H1(RN),\left\{\begin{array}{l}-\left(a+b\mathop{\displaystyle \int }\limits_{{{\mathbb{R}}}^{N}}| \nabla u\hspace{-0.25em}{| }^{2}{\rm{d}}x\right)\Delta u+V\left(| x| )u=| u\hspace{-0.25em}{| }^{2}u\hspace{1.0em}{\rm{in}}\hspace{0.33em}{{\mathbb{R}}}^{N},\\ u\in {H}^{1}\left({{\mathbb{R}}}^{N}),\end{array}\right. where a,b>0,N=2a,b\gt 0,N=2 or 3, the potential function VV is radial and bounded from below by a positive number. Because the nonlocal b∣∇u∣L2(RN)2Δub| \nabla u\hspace{-0.25em}{| }_{{L}^{2}\left({{\mathbb{R}}}^{N})}^{2}\Delta u is 3-homogeneous which is in complicated competition with the nonlinear term ∣u∣2u| u\hspace{-0.25em}{| }^{2}u. This causes that not all function in H1(RN){H}^{1}\left({{\mathbb{R}}}^{N}) can be projected on the Nehari manifold and thereby the classical Nehari manifold method does not work. By introducing the Gersgorin Disk theorem and the Miranda theorem, via a limit approach and subtle analysis, we prove that for each positive integer kk, equation (0.1) admits a radial nodal solution Uk,4b{U}_{k,4}^{b} having exactly kk nodes. Moreover, we show that the energy of Uk,4b{U}_{k,4}^{b} is strictly increasing in kk and for any sequence {bn}\left\{{b}_{n}\right\} with bn→0+,{b}_{n}\to {0}_{+}, up to a subsequence, Uk,4bn{U}_{k,4}^{{b}_{n}} converges to Uk,40{U}_{k,4}^{0} in H1(RN){H}^{1}\left({{\mathbb{R}}}^{N}), which is a radial nodal solution with exactly kk nodes of the classical Schrödinger equation −aΔu+V(∣x∣)u=∣u∣2uinRN,u∈H1(RN).\left\{\begin{array}{l}-a\Delta u+V\left(| x| )u=| u\hspace{-0.25em}{| }^{2}u\hspace{1.0em}{\rm{in}}\hspace{0.33em}{{\mathbb{R}}}^{N},\\ u\in {H}^{1}\left({{\mathbb{R}}}^{N}).\end{array}\right. Our results extend the existence result from the super-cubic case to the cubic case.

This article examines recent Sino-US film collaborations, focusing on Mulan (2020) against the backdrop of geopolitical shifts and the COVID-19 pandemic. Through in-depth interviews and a case study, it investigates the lukewarm reception of Mulan (2020) in China. The study explores how external pressures have disrupted the previously thriving partnership, leading to investment uncertainty, intensified censorship, and shifts in audience consumption towards online platforms, which have exacerbated piracy issues. It also addresses the political tensions surrounding Mulan (2020), including controversies related to Xinjiang and Hong Kong, which hindered its box-office success in Mainland China despite domestic support. A comparative analysis with Mulan (1998) assesses the evolution of feminist themes and filial piety in the 2020 adaptation. The findings indicate that while efforts were made to enhance feminist narratives and cultural motifs, the execution was superficial, treating complex cultural themes as mere embellishments rather than integral elements of the narrative. The film's portrayal of these themes within a predominantly Western framework highlights ongoing challenges in bridging cultural narratives in Sino-US film productions. The findings underscore the profound impact of geopolitics and reveal the contentious portrayal of feminism and cultural integration in Mulan (2020), emphasizing the challenges in Sino-US film collaborations. [ABSTRACT FROM AUTHOR]