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Objective: In a previous study we have shown that, in the presence of interleukin (IL)-33, repeated, per-nasal challenge of murine airways with Streptococcus pneumoniae (S. pneumoniae) organisms induces human asthma-like airways inflammation. It is not clear, however, whether this effect is unique or manifest in response to other common respiratory pathogens.Methods: To explore this, airways of BALB/c mice were repeatedly challenged per-nasally with formaldehyde-inactivated bacterial bodies in the presence or absence of murine recombinant IL-33. Serum concentrations of S.pneumoniae, Moraxella catarrhalis (M.catarrhalis) and Haemophilus influenzae (H.influenzae) lysates-specific IgE were measured in patients with asthma and control subjects.Results: We showed that in the presence of IL-33, repeated, per-nasal airways exposure to the bodies of these bacteria induced airways hyperresponsiveness (AHR) in the experimental mice. This was accompanied by cellular infiltration into bronchoalveolar lavage fluid (BALF), eosinophilic infiltration and mucous hypertrophy of the lung tissue, with elevated local expression of some type 2 cytokines and elevated, specific IgG and IgE in the serum. The precise characteristics of the inflammation evoked by exposure to each bacterial species were distinguishable.Conclusions: These results suggest that in the certain circumstances, inhaled or commensal bacterial body antigens of both Gram-positive (S. pneumoniae) and Gram-negative (M. catarrhalis and H. influenzae) respiratory tract bacteria may initiate type 2 inflammation typical of asthma in the airways. In addition, we demonstrated that human asthmatic patients manifest elevated serum concentrations of M.catarrhalis- and H.influenzae-specific IgE. [ABSTRACT FROM AUTHOR]

Creep is a fundamental time-dependent property of rock. As one of the main surrounding rocks of underground engineering, layered siltstone is governed by creep to a great extent because of special structure. Based on the structural characteristics of layered siltstone, a viscoelastic–viscoplastic model was proposed to simulate and present its creep property. To verify the accuracy of the model, governing equation of the viscoelastic–viscoplastic model was introduced into finite element difference program to simulate a series of creep tests of layered siltstone. Meanwhile, creep tests on layered siltstone were conducted. Numerical simulation results of the viscoelastic–viscoplastic model were compared with creep test data. Mean relative error of creep test data and numerical simulation result was 0.41%. Combined with Lyapunov function, the radial basis function (RBF) neural network trained with creep test data was adopted. Mean relative error of creep test data and RBF neural network data was 0.57%. The results further showed high accuracy and stability of RBF neural network and the viscoelastic–viscoplastic model.

This research examines the endorsement of the nationality stereotype Dutch = White among children and associations with citizenship representations of their mothers (Study 1). Additionally, Study 2 explores how mothers include the concept of Dutch citizenship in the upbringing of their children. Study 1 shows that children (n = 197, 57% girls, 7–13 years old) from different ethnic‐racial backgrounds (White Dutch, Turkish‐Dutch, Black Dutch, Chinese‐Dutch) all endorsed the nationality stereotype and did so to a similar extent. Most mothers rated civic citizenship as more important than ethnic citizenship, but maternal citizenship representations were unrelated to child nationality stereotype. Study 2 shows that mothers often do not actively and consciously include the topic of Dutch citizenship in their upbringing, but might confirm the nationality stereotype in more implicit ways. Future studies are needed to examine how to work towards a more inclusive view of nationality among children in the Dutch context. [ABSTRACT FROM AUTHOR]

BackgroundThe modular body structure of plants enables detached plant organs, such as postharvest fruits and vegetables, to maintain active responsiveness to environmental stimuli, including daily cycles of light and darkness. Twenty-four hour light/darkness cycles entrain plant circadian clock rhythms, which provide advantage to plants. Here, we tested whether green leafy vegetables gain longevity advantage by being stored under light/dark cycles designed to maintain biological rhythms.ResultsLight/dark cycles during postharvest storage improved several aspects of plant tissue performance comparable to that provided by refrigeration. Tissue integrity, green coloration, and chlorophyll content were generally enhanced by cycling of light and darkness compared to constant light or darkness during storage. In addition, the levels of the phytonutrient glucosinolates in kale and cabbage remained at higher levels over time when the leaf tissue was stored under light/dark cycles.ConclusionsMaintenance of the daily cycling of light and dark periods during postharvest storage may slow the decline of plant tissues, such as green leafy vegetables, improving not only appearance but also the health value of the crops through the maintenance of chlorophyll and phytochemical content after harvest.

Permutation flowshop design and optimization are crucial in industry as they have a direct impact on production scheduling and efficiency. The ultimate goal is to model the production system (PSM) based on revealing the fundamental principles of the production process, and to schedule or reschedule production release plans in real time without interrupting work-in-progress (WIP). Most existing PSMs are focused on static production processes which fail to describe the dynamic relationships between machines and buffers. Therefore, this paper establishes a PSM to characterize both the static and transient behaviors of automatic and manual machines in the permutation flowshop manufacturing system. Building upon the established PSM, based on Bernoulli's theory, discrete event model predictive control is proposed in this paper; its aim is to realize real-time optimization of production release plans without interfering with work-in-progress. According to the results of numerical examples, the discrete event model predictive control proposed in this paper is feasible and effective. The model established in this paper provides a theoretical basis for optimizing the effective operation of work-in-progress and replacement process systems. [ABSTRACT FROM AUTHOR]

High‐grade gliomas (HGGs) may be amenable to the neurosurgical technique known as laser interstitial thermal therapy (LITT), which delivers thermal energy to interstitial brain injuries and wounds with pinpoint accuracy. The purpose of this extensive meta‐analysis was to evaluate the effects of LITT on wound complications among patients who have brain tumours. Diverse conclusions emerge from a systematic review of pertinent studies, necessitating a comprehensive examination. The meta‐analysis, performed utilizing the meta library provided by the R package meta, reveals an initial significant overall effect (RR: −2.1262, 95% CI [−2.7466, −1.5059], p < 0.0001) accompanied by considerable heterogeneity among studies (I2 = 61.13%). Following analyses that specifically examined the incidence of wounds, a complex correlation was found (RR: 0.0471, 95% CI [0.0264, 0.0842], p < 0.0001), indicating that LITT has a discernible but insignificant effect on the occurrence of wounds. Although the meta‐analysis emphasizes a notable decrease in wound complications subsequent to LITT treatment, additional research is warranted due to constraints in standardized reporting, data accessibility, and small sample sizes. The results of this study underscore the need for exhaustive protocols to analyse wound complications in patients with brain tumours undergoing LITT. [ABSTRACT FROM AUTHOR]