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51. Trends in long‐term outcomes of patients with HCV‐associated hepatocellular carcinoma after hepatectomy: A comparison before and after introduction of direct‐acting antivirus therapy

Author

Munekage, Fumiaki, primary, Yoh, Tomoaki, additional, Ogiso, Satoshi, additional, Kato, Takuya, additional, Nam, Nguyen Hai, additional, Nagai, Kazuyuki, additional, Uchida, Yoichiro, additional, Ito, Takashi, additional, Ishii, Takamichi, additional, and Hatano, Etsuro, additional

Published
2023
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54. Nonsuperiority of technetium-99m-galactosyl human serum albumin scintigraphy over conventional volumetry for assessing the future liver remnant in patients undergoing hepatectomy after portal vein embolization

Author

20842826, 70456789, 90523118, Yao, Siyuan, Taura, Kojiro, Yoh, Tomoaki, Nishio, Takahiro, Koyama, Yukinori, Ogiso, Satoshi, Okamoto, Tatsuya, Fukumitsu, Ken, Ishii, Takamichi, Seo, Satoru, Hata, Koichiro, Masui, Toshihiko, Shimizu, Hironori, Ishimori, Takayoshi, Hatano, Etsuro, 20842826, 70456789, 90523118, Yao, Siyuan, Taura, Kojiro, Yoh, Tomoaki, Nishio, Takahiro, Koyama, Yukinori, Ogiso, Satoshi, Okamoto, Tatsuya, Fukumitsu, Ken, Ishii, Takamichi, Seo, Satoru, Hata, Koichiro, Masui, Toshihiko, Shimizu, Hironori, Ishimori, Takayoshi, and Hatano, Etsuro

Abstract

[Background] Technetium-99m-galactosyl human serum albumin scintigraphy is preferred for assessing the liver functional reserve in patients undergoing hepatectomy, but its superiority over computed tomography volumetry after portal vein embolization and subsequent hepatectomy remains elusive. We aimed to compare technetium-99m-galactosyl human serum albumin scintigraphy with conventional computed tomography volumetry for predicting posthepatectomy liver failure in patients after portal vein embolization. [Methods] This retrospective study analyzed 152 consecutive patients who underwent hepatobiliary cancer resection after portal vein embolization between 2006 and 2021. Posthepatectomy liver failure was graded according to the International Study Group of Liver Surgery criteria. The predictive abilities for posthepatectomy liver failure were compared between the future remnant uptake (%) by technetium-99m-galactosyl human serum albumin scintigraphy and the future remnant volume (%) by computed tomography volumetry. [Results] Future remnant uptake (%) was significantly greater than future remnant volume (%) after portal vein embolization (47.9% vs 40.8%; P < .001), while the values were comparable before portal vein embolization (32.7% vs 31.2%; P = .116). Receiver operating characteristic curve analysis revealed that post–portal vein embolization future remnant volume (%) had a significantly higher area under the curve than post–portal vein embolization future remnant uptake (%) (0.709 vs 0.630; P = .046) for predicting posthepatectomy liver failure. Multivariable analysis revealed that post–portal vein embolization future remnant volume (%) independently predicted posthepatectomy liver failure, but future remnant uptake (%) did not. Although the incidence of posthepatectomy liver failure grade ≥B was 17.8% when indocyanine green–clearance of the future liver remnant based on both future remnant volume (%) and future remnant uptake (%) was ≥0.05, it was higher in oth

Published
2023

55. Ferroptosis-related gene glutathione peroxidase 4 promotes reprogramming of glucose metabolism via Akt–mTOR axis in intrahepatic cholangiocarcinoma.

Author

Hori, Yutaro, Yoh, Tomoaki, Nishino, Hiroto, Okura, Keisuke, Kurimoto, Makoto, Takamatsu, Yuichi, Satoh, Motohiko, Nishio, Takahiro, Koyama, Yukinori, Ishii, Takamichi, Iwaisako, Keiko, Seo, Satoru, and Hatano, Etsuro

Subjects
*GLUTATHIONE peroxidase, *GLUCOSE metabolism, *CHOLANGIOCARCINOMA, *GENE expression, *CELL migration, *WARBURG Effect (Oncology)
Abstract

The role of the ferroptosis-related gene glutathione peroxidase 4 (GPX4) in oncology has been extensively investigated. However, the clinical implications of GPX4 in patients with intrahepatic cholangiocarcinoma (ICC) remain unknown. This study aimed to evaluate the prognostic impact of GPX4 and its underlying molecular mechanisms in patients with ICC. Fifty-seven patients who underwent surgical resection for ICC between 2010 and 2017 were retrospectively analyzed. Based on the immunohistochemistry, patients were divided into GPX4 high (n  = 15) and low (n  = 42) groups, and clinical outcomes were assessed. Furthermore, the roles of GPX4 in cell proliferation, migration and gene expression were analyzed in ICC cell lines in vitro and in vivo. The results from clinical study showed that GPX4 high group showed significant associations with high SUVmax on 18F-fluorodeoxyglucose-positron emission tomography (≥8.0, P  = 0.017), multiple tumors (P  = 0.004), and showed glucose transporter 1 (GLUT1) high expression with a trend toward significance (P  = 0.053). Overall and recurrence-free survival in the GPX4 high expression group were significantly worse than those in the GPX4 low expression group (P  = 0.038 and P  < 0.001, respectively). In the experimental study, inhibition of GPX4 attenuated cell proliferation and migration in ICC cell lines. Inhibition of GPX4 also decreased the expression of glucose metabolism-related genes, such as GLUT1 or HIF1α. Mechanistically, these molecular changes are regulated in Akt–mechanistic targets of rapamycin axis. In conclusion, this study suggested the pivotal value of GPX4 serving as a prognostic marker for patients with ICC. Furthermore, GPX4 can mediate glucose metabolism of ICC. [ABSTRACT FROM AUTHOR]

Published
2024
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56. Trends in long‐term outcomes of patients with HCV‐associated hepatocellular carcinoma after hepatectomy: A comparison before and after introduction of direct‐acting antivirus therapy.

Author

Munekage, Fumiaki, Yoh, Tomoaki, Ogiso, Satoshi, Kato, Takuya, Nam, Nguyen Hai, Nagai, Kazuyuki, Uchida, Yoichiro, Ito, Takashi, Ishii, Takamichi, and Hatano, Etsuro

Subjects
HEPATITIS C, HEPATOCELLULAR carcinoma, HEPATECTOMY, HEPATITIS C virus, PROPENSITY score matching, SURVIVAL rate
Abstract

Backgrounds: The success of direct‐acting antiviral (DAA) therapy provides a cure for patients chronically infected with hepatitis C virus (HCV); however, outcomes after hepatectomy for HCV‐associated hepatocellular carcinoma (HCC) before and after DAA introduction remain poorly studied. Methods: Patients who underwent R0/R1 hepatectomy for HCV‐associated HCC were retrospectively analyzed. Two time periods were defined: Pre‐DAA (2007–2011, December 2013 was defined as the end of follow‐up) and Post‐DAA groups (2014–2018, December 2020 was defined as the end of follow‐up). Propensity score matching (PSM) analyses were performed to highlight the effect of DAA therapy. Results: A total of 155 patients with HCV‐associated HCC were included in this study (Pre‐DAA group, n = 103 and post‐DAA group, n = 52). In the Post‐DAA group, DAA therapy was performed in 26 patients (50.0%), and all of these patients achieved sustained virologic response (SVR) (preoperative SVR, n = 7; postoperative SVR, n = 19). There was no significant difference between the two groups regarding surgical settings and tumor pathology. There was no significant difference in the 5‐year overall survival (OS) rate (61.1% and 64.8%, pre‐ and post‐DAA group, respectively, p = 0.441); meanwhile, the 5‐year recurrence‐free survival (RFS) rate in the post‐DAA group was better than the pre‐DAA group (21.1% and 40.2%, p = 0.073) with a trend toward significance. After PSM except for the postoperative SVR status, there were no significant differences in OS (p = 0.586) and RFS (p = 0.888). Conclusions: This study showed that survival outcomes were not changed in hepatectomized cases of HCV‐associated HCC before and after the introduction of DAA therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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63. Supplementary Data from Serum Nardilysin, a Surrogate Marker for Epithelial–Mesenchymal Transition, Predicts Prognosis of Intrahepatic Cholangiocarcinoma after Surgical Resection

Author

Yoh, Tomoaki, primary, Hatano, Etsuro, primary, Kasai, Yosuke, primary, Fuji, Hiroaki, primary, Nishi, Kiyoto, primary, Toriguchi, Kan, primary, Sueoka, Hideaki, primary, Ohno, Mikiko, primary, Seo, Satoru, primary, Iwaisako, Keiko, primary, Taura, Kojiro, primary, Yamaguchi, Rina, primary, Kurokawa, Masato, primary, Fujimoto, Jiro, primary, Kimura, Takeshi, primary, Uemoto, Shinji, primary, and Nishi, Eiichiro, primary

Published
2023
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70. Bile Duct Regeneration with an Artificial Bile Duct Made of Gelatin Hydrogel Nonwoven Fabrics

Author

Uemoto, Yusuke, primary, Taura, Kojiro, additional, Nakamura, Daichi, additional, Xuefeng, Li, additional, Nam, Nguyen Hai, additional, Kimura, Yusuke, additional, Yoshino, Kenji, additional, Fuji, Hiroaki, additional, Yoh, Tomoaki, additional, Nishio, Takahiro, additional, Yamamoto, Gen, additional, Koyama, Yukinori, additional, Seo, Satoru, additional, Tsuruyama, Tatsuaki, additional, Iwaisako, Keiko, additional, Uemoto, Shinji, additional, Tabata, Yasuhiko, additional, and Hatano, Etsuro, additional

Published
2022
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71. Increased expression of programmed cell death ligand 1 and galectin 9 in transplant recipients who achieved tolerance after immunosuppression withdrawal

Author

Nam, Nguyen Hai, primary, Taura, Kojiro, additional, Koyama, Yukinori, additional, Nishio, Takahiro, additional, Yamamoto, Gen, additional, Uemoto, Yusuke, additional, Kimura, Yusuke, additional, Xuefeng, Li, additional, Nakamura, Daichi, additional, Yoshino, Kenji, additional, Ogawa, Eri, additional, Okamoto, Tatsuya, additional, Yoshizawa, Atsushi, additional, Seo, Satoru, additional, Iwaisako, Keiko, additional, Yoh, Tomoaki, additional, Hata, Koichiro, additional, Masui, Toshihiko, additional, Okajima, Hideaki, additional, Haga, Hironori, additional, Uemoto, Shinji, additional, and Hatano, Etsuro, additional

Published
2022
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73. The usefulness of preoperative bile cultures for hepatectomy with biliary reconstruction

Author

70456789, 20842826, Makino, Kenta, Ishii, Takamichi, Yoh, Tomoaki, Ogiso, Satoshi, Fukumitsu, Ken, Seo, Satoru, Taura, Kojiro, Hatano, Etsuro, 70456789, 20842826, Makino, Kenta, Ishii, Takamichi, Yoh, Tomoaki, Ogiso, Satoshi, Fukumitsu, Ken, Seo, Satoru, Taura, Kojiro, and Hatano, Etsuro

Abstract

[Background] Infectious complications can cause lethal liver failure after hepatectomy with biliary reconstruction. This study assessed the increased risk for postoperative infectious complications in patients who underwent hepatectomy with biliary reconstruction and explored the possibility of predicting pathogenic microorganisms causing postoperative infectious complications based on preoperative monitoring of bile cultures. [Methods] This study involved 310 patients who received major hepatectomy with or without biliary reconstruction at our institution between January 2010 and December 2019. The relationship between the microorganisms detected through perioperative monitoring of bile culture and those in the postoperative infectious foci was examined. [Results] Forty-nine patients underwent major hepatectomy with biliary reconstruction, and 261 received hepatectomy without biliary reconstruction. The multivariate analysis revealed hepatectomy with biliary reconstruction to be associated with an increased risk of postoperative infectious complications (odds ratio: 22.9, 95% confidence interval: 5.2–164.3) compared to hepatectomy without biliary reconstruction. In the patients with biliary reconstruction, the concordance rates between the microorganisms detected in the postoperative infectious foci and those in preoperative bile cultures were as follows: incisional surgical site infection (44.4%), organ/space surgical site infection (52.9%), bacteremia (47.1%), and pneumonia (16.7%); the concordance rates were high, and the risk of infection increased over time. [Conclusions] Biliary reconstruction is a significant risk factor for postoperative infectious complications, and preoperative bile cultures may aid in prophylactic and therapeutic antimicrobial agent selection.

Published
2022

74. Dissecting aneurysm of the proper hepatic artery after laparoscopic hepatectomy possibly related to the Pringle maneuver: A case report

Author

20842826, 90566811, 70456789, 90523118, Kurimoto, Makoto, Seo, Satoru, Yoh, Tomoaki, Shimizu, Hironori, Masano, Yuki, Ogiso, Satoshi, Anazawa, Takayuki, Ishii, Takamichi, Hata, Koichiro, Masui, Toshihiko, Taura, Kojiro, Hatano, Etsuro, 20842826, 90566811, 70456789, 90523118, Kurimoto, Makoto, Seo, Satoru, Yoh, Tomoaki, Shimizu, Hironori, Masano, Yuki, Ogiso, Satoshi, Anazawa, Takayuki, Ishii, Takamichi, Hata, Koichiro, Masui, Toshihiko, Taura, Kojiro, and Hatano, Etsuro

Abstract

In hepatectomy, the Pringle maneuver is commonly used, but its association with iatrogenic injury is not yet well understood. This report presents a case of dissecting aneurysm of the proper hepatic artery (PHA) possibly associated with the Pringle maneuver during laparoscopic hepatectomy, that was successfully treated by transcatheter arterial embolization (TAE). The patient was a woman in her 70s, and repeat hepatectomy for liver metastasis of rectal neuroendocrine neoplasm was planned. She underwent hand-assisted laparoscopic hepatectomy with the Pringle maneuver. On postoperative day (POD) 7, enhanced computed tomography showed a dissecting aneurysm of the PHA. TAE of the PHA to prevent hemorrhage was performed on POD 9 with no complications. Even after TAE, intrahepatic arterial flow was provided by the peribiliary arteries. This case suggests the possibility that the Pringle maneuver can cause a dissecting aneurysm of the hepatic artery.

Published
2022

75. Bile Duct Regeneration with an Artificial Bile Duct Made of Gelatin Hydrogel Nonwoven Fabrics

Author

20842826, 90450238, 50211371, Uemoto, Yusuke, Taura, Kojiro, Nakamura, Daichi, Xuefeng, Li, Nam, Nguyen Hai, Kimura, Yusuke, Yoshino, Kenji, Fuji, Hiroaki, Yoh, Tomoaki, Nishio, Takahiro, Yamamoto, Gen, Koyama, Yukinori, Seo, Satoru, Tsuruyama, Tatsuaki, Iwaisako, Keiko, Uemoto, Shinji, Tabata, Yasuhiko, Hatano, Etsuro, 20842826, 90450238, 50211371, Uemoto, Yusuke, Taura, Kojiro, Nakamura, Daichi, Xuefeng, Li, Nam, Nguyen Hai, Kimura, Yusuke, Yoshino, Kenji, Fuji, Hiroaki, Yoh, Tomoaki, Nishio, Takahiro, Yamamoto, Gen, Koyama, Yukinori, Seo, Satoru, Tsuruyama, Tatsuaki, Iwaisako, Keiko, Uemoto, Shinji, Tabata, Yasuhiko, and Hatano, Etsuro

Abstract

Although choledochojejunostomy is the standard technique for biliary reconstruction, there are various associated problems that need to be solved such as reflux cholangitis. Interposition with an artificial bile duct (ABD) to replace the resected bile duct maintains a physiological conduit for bile and may solve this problem. This study investigated the usefulness of an ABD made of gelatin hydrogel nonwoven fabric (GHNF). GHNF was prepared by the solution blow spinning method. The migration and activity of murine fibroblast L929 cells were examined in GHNF sheets. L929 cells migrated into GHNF sheets, where they proliferated and synthesized collagen, suggesting GHNF is a promising scaffold for bile duct regeneration. ABDs made of GHNF were implanted in place of resected bile duct segments in rats. The rats were killed at 2, 6, and 12 weeks postimplantation. The implantation site was histologically evaluated for bile duct regeneration. At postoperative 2 weeks, migrating cells were observed in the ABD pores. The implanted ABD was mostly degraded and replaced by collagen fibers at 6 weeks. Ki67-positive bile duct epithelial cells appeared within the implanted ABD. These were most abundant within the central part of the ABD after 6 weeks. The percentages of Ki67-positive cells were 31.7 ± 9.1% in the experimental group and 0.8 ± 0.6% in the sham operation group at 6 weeks (p < 0.05), indicating that mature biliary epithelial cells at the stump proliferated to regenerate the biliary epithelium. Biliary epithelial cells had almost completely covered the bile duct lumen at 12 weeks (epithelialization ratios: 10.4 ± 6.9% at 2 weeks, 93.1 ± 5.1% at 6 weeks, 99.2 ± 1.6% at 12 weeks). The regenerated epithelium was positive for the bile duct epithelium marker cytokeratin 19. Bile duct regeneration was accompanied by angiogenesis, as evidenced by the appearance of CD31-positive vascular structures. Capillaries were induced 2 weeks after implantation. The number of capillaries

Published
2022

78. An International Retrospective Observational Study of Liver Functional Deterioration after Repeat Liver Resection for Patients with Hepatocellular Carcinoma

Author

Morise, Zenichi, primary, Aldrighetti, Luca, additional, Belli, Giulio, additional, Ratti, Francesca, additional, Cheung, Tan To, additional, Lo, Chung Mau, additional, Tanaka, Shogo, additional, Kubo, Shoji, additional, Okamura, Yukiyasu, additional, Uesaka, Katsuhiko, additional, Monden, Kazuteru, additional, Sadamori, Hiroshi, additional, Hashida, Kazuki, additional, Kawamoto, Kazuyuki, additional, Gotohda, Naoto, additional, Chen, KuoHsin, additional, Kanazawa, Akishige, additional, Takeda, Yutaka, additional, Ohmura, Yoshiaki, additional, Ueno, Masaki, additional, Ogura, Toshiro, additional, Suh, Kyung Suk, additional, Kato, Yutaro, additional, Sugioka, Atsushi, additional, Belli, Andrea, additional, Nitta, Hiroyuki, additional, Yasunaga, Masafumi, additional, Cherqui, Daniel, additional, Halim, Nasser Abdul, additional, Laurent, Alexis, additional, Kaneko, Hironori, additional, Otsuka, Yuichiro, additional, Kim, Ki Hun, additional, Cho, Hwui-Dong, additional, Lin, Charles Chung-Wei, additional, Ome, Yusuke, additional, Seyama, Yasuji, additional, Troisi, Roberto I., additional, Berardi, Giammauro, additional, Rotellar, Fernando, additional, Wilson, Gregory C., additional, Geller, David A., additional, Soubrane, Olivier, additional, Yoh, Tomoaki, additional, Kaizu, Takashi, additional, Kumamoto, Yusuke, additional, Han, Ho-Seong, additional, Ekmekcigil, Ela, additional, Dagher, Ibrahim, additional, Fuks, David, additional, Gayet, Brice, additional, Buell, Joseph F., additional, Ciria, Ruben, additional, Briceno, Javier, additional, O’Rourke, Nicholas, additional, Lewin, Joel, additional, Edwin, Bjorn, additional, Shinoda, Masahiro, additional, Abe, Yuta, additional, Hilal, Mohammed Abu, additional, Alzoubi, Mohammad, additional, Tanabe, Minoru, additional, and Wakabayashi, Go, additional

Published
2022
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79. EP1202: QUANTITATIVE ASSESSMENT OF MICROVASCULAR INVASION IN HEPATOCELLULAR CARCINOMA USING PREOPERATIVE DCP AND FDGPET

Author

Seo, Satoru, primary, Yoh, Tomoaki, additional, Kurimoto, Makoto, additional, Takamatsu, Yuichi, additional, Hori, Yutaro, additional, Toda, Rei, additional, Nishio, Takahiro, additional, Koyama, Yukinori, additional, Ogiso, Satoshi, additional, Fukumitsu, Ken, additional, Ishii, Takamichi, additional, Taura, Kojiro, additional, and Hatano, Etsuro, additional

Published
2022
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82. Utility of serum autotaxin levels for predicting post hepatectomy liver failure in hepatocellular carcinoma.

Author

Uemoto, Yusuke, Taura, Kojiro, Kimura, Yusuke, Yoh, Tomoaki, Nishio, Takahiro, Koyama, Yukinori, Seo, Satoru, Okazaki, Kazuyuki, Nagao, Miki, Igarashi, Koji, and Hatano, Etsuro

Abstract

Background/Purpose: This study aimed to evaluate the usefulness of serum autotaxin, a novel liver fibrosis marker, for predicting post hepatectomy liver failure (PHLF) in patients undergoing hepatectomy for hepatocellular carcinoma (HCC). Methods: Autotaxin was measured in sera from 269 patients undergoing hepatectomy for HCC. Correlations between autotaxin level, liver fibrosis stage (METAVIR F0–F4), and PHLF, as assessed by the International Study Group of Liver Surgery criteria, were analyzed. Results: Median autotaxin concentrations correlated significantly with fibrosis stage (F0, 0.93; F1, 0.96; F2, 1.18; F3, 1.40; and F4, 1.47 mg/l; P <.0001). Autotaxin levels were significantly higher in female patients and hepatitis C virus antibody‐positive patients compared with male or antibody‐negative patients (P <.0001). PHLF grade ≥ B occurred in 25 patients (9.3%). A PHLF prediction model was constructed from four variables (autotaxin, resection rate, sex, and hepatitis C virus antibody positivity) and gave an area under the receiver operating characteristic curve of 0.8 (95% confidence interval [CI]: 0.69–0.87), which was superior to models based on ALPlat and resection rate (0.75, 95% CI: 0.64–0.83) or indocyanine green retention test and resection rate (0.72, 95% CI: 0.61–0.81). Conclusion: Serum autotaxin has utility for predicting liver fibrosis and PHLF in patients with HCC. [ABSTRACT FROM AUTHOR]

Published
2023
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83. Dissecting aneurysm of the proper hepatic artery after laparoscopic hepatectomy possibly related to the Pringle maneuver: A case report

Author

Kurimoto, Makoto, primary, Seo, Satoru, additional, Yoh, Tomoaki, additional, Shimizu, Hironori, additional, Masano, Yuki, additional, Ogiso, Satoshi, additional, Anazawa, Takayuki, additional, Ishii, Takamichi, additional, Hata, Koichiro, additional, Masui, Toshihiko, additional, Taura, Kojiro, additional, and Hatano, Etsuro, additional

Published
2022
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85. Reappraisal of Prognostic Impact of Tumor SUVmax by F-FDG-PET/CT in Intrahepatic Cholangiocarcinoma

Author

Yoh, Tomoaki, Seo, Satoru, Morino, Koshiro, Fuji, Hiroaki, Ikeno, Yoshinobu, Ishii, Takamichi, Taura, Kojiro, Nakamoto, Yuji, Higashi, Tatsuya, Kaido, Toshimi, and Uemoto, Shinji

Abstract

We previously reported that tumor standardized uptake value (SUVmax) by F-fluorodeoxyglucose-positron emission tomography/computed tomography (PET/CT) was a potential predictor in patients undergoing surgery for intrahepatic cholangiocarcinoma (ICC). However, the prognostic value of SUVmax in the era of multidisciplinary strategy has remained unclear. The aim of this study was to reappraise the prognostic value of tumor SUVmax in patients undergoing surgery for ICC.

Published
2019

86. Increased Expressions of Programmed Death Ligand 1 and Galectin 9 in Transplant Recipients Who Achieved Tolerance After Immunosuppression Withdrawal

Author

Hai Nam, Nguyen, primary, Taura, Kojiro, additional, Koyama, Yukinori, additional, Nishio, Takahiro, additional, Yamamoto, Gen, additional, Uemoto, Yusuke, additional, Kimura, Yusuke, additional, Xuefeng, Li, additional, Nakamura, Daichi, additional, Yoshino, Kenji, additional, Ogawa, Eri, additional, Okamoto, Tatsuya, additional, Yoshizawa, Atsushi, additional, Seo, Satoru, additional, Iwaisako, Keiko, additional, Yoh, Tomoaki, additional, Hata, Koichiro, additional, Masui, Toshihiko, additional, Okajima, Hideaki, additional, Haga, Hironori, additional, Uemoto, Shinji, additional, and Hatano, Etsuro, additional

Published
2021
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92. Multicenter Propensity Score-Based Study of Laparoscopic Repeat Liver Resection for Hepatocellular Carcinoma: A Subgroup Analysis of Cases with Tumors Far from Major Vessels

Author

Miyama, Arimasa, primary, Morise, Zenichi, additional, Aldrighetti, Luca, additional, Belli, Giulio, additional, Ratti, Francesca, additional, Cheung, Tan-To, additional, Lo, Chung-Mau, additional, Tanaka, Shogo, additional, Kubo, Shoji, additional, Okamura, Yukiyasu, additional, Uesaka, Katsuhiko, additional, Monden, Kazuteru, additional, Sadamori, Hiroshi, additional, Hashida, Kazuki, additional, Kawamoto, Kazuyuki, additional, Gotohda, Naoto, additional, Chen, KuoHsin, additional, Kanazawa, Akishige, additional, Takeda, Yutaka, additional, Ohmura, Yoshiaki, additional, Ueno, Masaki, additional, Ogura, Toshiro, additional, Suh, Kyung-Suk, additional, Kato, Yutaro, additional, Sugioka, Atsushi, additional, Belli, Andrea, additional, Nitta, Hiroyuki, additional, Yasunaga, Masafumi, additional, Cherqui, Daniel, additional, Halim, Nasser Abdul, additional, Laurent, Alexis, additional, Kaneko, Hironori, additional, Otsuka, Yuichiro, additional, Kim, Ki-Hun, additional, Cho, Hwui-Dong, additional, Lin, Charles Chung-Wei, additional, Ome, Yusuke, additional, Seyama, Yasuji, additional, Troisi, Roberto I., additional, Berardi, Giammauro, additional, Rotellar, Fernando, additional, Wilson, Gregory C., additional, Geller, David A., additional, Soubrane, Olivier, additional, Yoh, Tomoaki, additional, Kaizu, Takashi, additional, Kumamoto, Yusuke, additional, Han, Ho-Seong, additional, Ekmekcigil, Ela, additional, Dagher, Ibrahim, additional, Fuks, David, additional, Gayet, Brice, additional, Buell, Joseph F., additional, Ciria, Ruben, additional, Briceno, Javier, additional, O’Rourke, Nicholas, additional, Lewin, Joel, additional, Edwin, Bjorn, additional, Shinoda, Masahiro, additional, Abe, Yuta, additional, Hilal, Mohammed Abu, additional, Alzoubi, Mohammad, additional, Tanabe, Minoru, additional, and Wakabayashi, Go, additional

Published
2021
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98. Increased Expressions of Programmed Death Ligand 1 and Galectin 9 in Transplant Recipients Who Achieved Tolerance After Immunosuppression Withdrawal.

Author

Hai Nam, Nguyen, Taura, Kojiro, Koyama, Yukinori, Nishio, Takahiro, Yamamoto, Gen, Uemoto, Yusuke, Kimura, Yusuke, Xuefeng, Li, Nakamura, Daichi, Yoshino, Kenji, Ogawa, Eri, Okamoto, Tatsuya, Yoshizawa, Atsushi, Seo, Satoru, Iwaisako, Keiko, Yoh, Tomoaki, Hata, Koichiro, Masui, Toshihiko, Okajima, Hideaki, and Haga, Hironori

Published
2022
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99. THU167 - Increased expression of programmed cell death ligand 1 and galectin 9 in transplant recipients who achieved tolerance after immunosuppression withdrawal

Author

Nam, Nguyen Hai, Taura, Kojiro, Koyama, Yukinori, Nishio, Takahiro, Yamamoto, Gen, Uemoto, Yusuke, Kimura, Yusuke, Xuefeng, Li, Nakamura, Daichi, Yoshino, Kenji, Ogawa, Eri, Okamoto, Tatsuya, Yoshizawa, Atsushi, Seo, Satoru, Iwaisako, Keiko, Yoh, Tomoaki, Hata, Koichiro, Masui, Toshihiko, Okajima, Hideaki, Haga, Hironori, Uemoto, Shinji, and Hatano, Etsuro

Published
2022
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100. Identifying Patients Who May Benefit from Liver Resection Compared to Living Donor Liver Transplantation for Hepatocellular Carcinoma Using 18F-FDG PET.

Author

Yoh, Tomoaki, Seo, Satoru, Taura, Kojiro, Hamaguchi, Yuhei, Ogiso, Satoshi, Fukumitsu, Ken, Ishii, Takamichi, Hata, Koichiro, Kaido, Toshimi, Nakamoto, Yuji, and Uemoto, Shinji

Subjects
LIVER transplantation, HEPATOCELLULAR carcinoma, OVERALL survival, SURVIVAL rate, POSITRON emission tomography
Abstract

Background: This study aimed to assess an oncologic setting where patients with hepatocellular carcinoma (HCC) could benefit from liver resection (LR) compared to living donor liver transplantation (LDLT) using 18F-fluorodeoxyglucose (FDG) positron emission tomography. Methods: The consecutive data of patients with HCC who underwent 18F-FDG PET before LR (LR group, n = 314) and LDLT (LDLT group, n = 65) between 2003 and 2015 were retrospectively analyzed. Tumor 18F-FDG avidity was quantified as the tumor to liver standardized uptake value ratio (TLR, cut-off value was defined at 2). Multivariate analysis was performed to assess significant preoperative tumor factors in the LR group. Survival outcomes between the two groups were stratified by these factors. Results: The 5-year overall survival (OS: 56.9% vs. 73.8%, LR vs. LDLT, p < 0.001) and recurrence-free survival rate (RFS: 27.4% vs. 70.7%, p < 0.001) were significantly better in the LDLT group compared to the LR group. In the LR study, multivariate analysis identified TLR and tumor multiplicity as significant preoperative tumor factors for OS. In patients with solitary and TLR < 2 HCC, the 5-year OS rate was not significantly different between the LR and LDLT groups (70.3% vs. 71.8%, p = 0.352); meanwhile, RFS rate was better in the LDLT group (34.3% vs. 71.8%, p = 0.001). Conclusions: LDLT is associated with better long-term outcomes than LR in patients with HCC; however, selected patients with solitary and TLR < 2 HCC may benefit from LR. [ABSTRACT FROM AUTHOR]

Published
2021
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